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It was not possible to detect BRAF V600E mutation in circulating cell-free DNA from patients with ameloblastoma: A diagnostic accuracy study J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-03-17 Allan Vinícius Martins-de-Barros, Fábio Andrey da Costa Araújo, Ana Maria Ipólito Barros, Elenisa Glaucia Ferreira dos Santos, Adauto Gomes Barbosa Neto, Helker Albuquerque Macedo da Silva, Elker Lene Santos de Lima, Maria Tereza Cartaxo Muniz, Riedel Frota Sá Nogueira Neves, Rômulo Oliveira de Hollanda Valente, Emanuel Dias de Oliveira e Silva, Marianne de Vasconcelos Carvalho
The objective of this study is to evaluate the diagnostic accuracy of plasma-based liquid biopsy for the detection of the BRAF V600E mutation in circulating cell-free DNA from patients with ameloblastoma.
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Tumor immune microenvironment in odontogenic carcinomas: Evaluation of the therapeutic potential of immune checkpoint blockade J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-03-06 Kyu-Young Oh, Seong-Doo Hong, Hye-Jung Yoon
Despite recent advances in the use of immune checkpoint blockade (ICB) across various cancer types, its efficacy in odontogenic carcinomas remains unexplored. This study aims to investigate PD-L1 expression and the tumor immune microenvironment (TIME) in odontogenic carcinomas to determine the therapeutic potential of ICB and the significance of immune markers.
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Salivary and serum biomarkers to evaluate psychological disorders in burning mouth syndrome: A systematic review and meta-analysis J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-03-04 Mei He, Wuda Huoshen, Xueqing Li, Chen Sun
Burning mouth syndrome is a chronic pain syndrome mainly characterized by an intensive burning sensation of tongue. Previous studies have suggested that saliva/serum biomarkers in burning mouth syndrome might be associated with psychological disorders. The aim of systematic review was to observe whether the biomarkers in serum/saliva could be an alternative method to evaluate the psychological disorders
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Corrigendum: The expression of MACC1 and its role in the proliferation and apoptosis of salivary adenoid cystic carcinoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-29
Haifeng L, Liao X, Shen Z, Xiangfeng G, Haigang L, Huang Z. The expression of MACC1 and its role in the proliferation and apoptosis of salivary adenoid cystic carcinoma. J Oral Pathol Med. 2015; 44: 810-817. The revision of our manuscript is prompted by the concerns raised by Jennifer Byrne and colleagues regarding the nucleotide sequence reagents used in our paper titled “The expression of MACC1 and
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Depth of invasion of oral squamous cell carcinoma in Nos2-knockout mice correlated to alterations in systemic inflammatory markers following 4NQO treatment J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-28 Débora de Oliveira Santos, Anaíra Ribeiro Guedes Fonseca Costa, Pedro Victor Silva Duarte, Tássio Edno Atanásio Pitorro, Lúbia Cristina Fonseca, Sérgio Vitorino Cardoso, Paulo Rogério de Faria, Adriano Mota Loyola
Peripheral blood analysis is a non-invasive and low-cost technique of prognostic value for several diseases, including oral cancer. Considering the role of inducible nitric oxide synthase in tumor-associated inflammation, this study purposed to evaluate the influence of this enzyme on peripheral blood parameters and systemic inflammatory biomarkers during murine oral carcinogenesis.
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Evaluation of possible role of fluoride in pathogenesis of oral submucous fibrosis: A pilot study J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-28 Gururaj Arakeri, Vishal Rao US, Shekar Patil, Sateesh Kunigal, Roopa Reddy, Murugesan Krishnan, Beverley Hale, Peter A. Brennan
Oral submucous fibrosis (OSMF) is a potentially malignant disorder. Although areca nut chewing is an established risk factor, its low prevalence among nut chewers indicates additional factors likely facilitates pathogenesis. We recently demonstrated high fluoride levels in smokeless tobacco products and hypothesized a potential pathological role of fluoride in OSMF. Further exploring this novel role
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Expression of TNF-α, omentin-1, and IL-6 before and after adjunctive treatment with a bioactive antimicrobial peptide periodontal gel J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-25 Bo Zhang, Lulu Wang, Chang Liu
The objective of this study was to evaluate and compare the expression levels of TNF-α, omentin-1, and IL-6 in periodontitis patients before and after treatment with biological antimicrobial peptide (AMP) periodontal gel.
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Cover Image J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-22 Mai Seki, Takaaki Sano, Emi Saito, Masaru Ogawa, Satoshi Yokoo, Tetsunari Oyama
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Professor Emeritus Newell W. Johnson, CMG; FMedSci J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-22 Saman Warnakulasuriya, Lakshman Samaranayake, W. M. Tillakaratne
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A call for the development of a clinical tool to quantify lifetime betel quid exposure, inspired by the pack‐years concept in smoking—Betel‐years J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-21 Hamrish Kumar Rajakumar, Varsha Coimbatore Sathyabal
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Ameloblastic carcinoma: A systematic review J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-18 Liam Robinson, Lucas Guimarães Abreu, Felipe Paiva Fonseca, Keith D. Hunter, Melvin A. Ambele, Willie F. P. van Heerden
Ameloblastic carcinoma (AC) is the most common odontogenic malignancy, constituting approximately 30% of cases in this category. Literature is sparse on malignant odontogenic neoplasms, with a large proportion of current knowledge derived from case reports or small case series.
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Ultrasonography use for tongue cancer management: A scoping review J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-14 Luiz Cláudio Pires Duarte, Karlayle Teixeira, Barbara Magalhães Figueiredo Dias, Felipe Paiva Fonseca, Denise Vieira Travassos, Chané Smit, Maurício Augusto Aquino de Castro, Aline Araujo Sampaio
Tongue cancer is associated with debilitating diseases and poor prognostic outcomes. The use of imaging techniques like ultrasonography to assist in the clinical management of affected patients is desirable, but its reliability remains debatable. Therefore, the aim of this study is to investigate the importance of ultrasound use for the clinicopathological management of tongue cancer.
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E-CADERIN, N-CADERIN, SLUG, SNAIL, and TWIST contribute to epithelial-mesenchymal transition in salivary gland tumors J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-13 Dandara Andrade de Santana, Poliana Ramos Braga, Cláudia Malheiros Camillo-Coutinho, Valéria Souza Freitas, Patrícia Ramos Cury, Daniel Araki Ribeiro, Iguaracyra Barreto de Araújo, Flávia Caló de Aquino Xavier, Jean Nunes dos Santos
Transcription factors are important in the epithelial-mesenchymal transition process and are possibly related to the development of a more invasive tumor phenotype. Thus, the objective of this study was to analyze the expression and identify the localization of cellular markers related to the epithelial-mesenchymal transition process in salivary gland tumors.
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HHLA2 is more significantly associated with poor prognosis in TSCC than PD-L1 J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-06 Yi Li, Qiong Yang, Xu Yang, Jie Ge, Tianshu Xu, HuaLian Liu
The incidence and mortality of tongue squamous cell carcinoma have shown an alarming increase in recent years. This study aimed to investigate the potential of HHLA2 as an immune checkpoint in comparison to PD-L1.
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Epigenetics in the diagnosis and prognosis of head and neck cancer: A systematic review J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-02-05 Isaac Lim, Jade Tan, Anneka Alam, Majdy Idrees, Peter A. Brenan, Ricardo Della Coletta, Omar Kujan
Aberrant epigenetic modifications significantly develop and progress human malignancies including head and neck squamous cell carcinoma (HNSCC). Taking into account issues of late diagnosis and poor prognosis associated with HNSCC, this systematic review is designed to provide an up-to-date insight of epigenetic changes in the management of HNSCC.
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B12 deficiency-related glossitis is highly associated with high gastrin-17 and low pepsinogen I J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-01-30 Jingci Zhu, Yining He, Huang Feng, Yufeng Wang, Zili Ge
The causes of vitamin B12 (B12) deficiency are varied and mainly related to gastric disorders. Glossitis is a common oral manifestation of B12 deficiency and is often first seen by dentists. This study aimed to investigate the correlation between B12 deficiency-related glossitis (B12-def glossitis) and gastric serum biomarkers [gastrin-17(G17), pepsinogen I (PGI), pepsinogen II (PGII), and anti-Helicobacter
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Transcriptomic analysis of the submandibular gland under psychological stress condition J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-01-30 Durga Paudel, Osamu Uehara, Sarita Giri, Tetsuro Morikawa, Koki Yoshida, Takao Kitagawa, Dedy Ariwansa, Nisha Acharya, Kazunori Ninomiya, Yasuhiro Kuramitsu, Tohru Ohta, Masanobu Kobayashi, Yoshihiro Abiko
Psychological stress is associated with changes in salivary flow and composition. However, studies to show the effect of psychological stress on the transcriptome of the salivary gland are limited. This study aims to perform a transcriptomic analysis of the submandibular gland under psychological stress using a chronic restraint stress model of rats.
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Ubiquitination, SUMOylation, and NEDDylation related genes serve as prognostic and therapeutic biomarkers for oral squamous cell carcinoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-01-17 Shi-Zhou Deng, Xuechen Wu, Lingshu Kong, Bo Cheng, Lin Dai
Ubiquitination, small ubiquitin-related modifiers, and NEDDylation are now found to function in cancer biology; however, its role in the oral cancer patients remains unclear.
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Clinicoradiologic features of ameloblastomas: A single-centre study of 155 cases J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-01-11 Chané Smit, Liam Robinson, Jason Ker-Fox, Felipe Paiva Fonseca, Willie F. P. van Heerden, André Uys
The purpose of the current study was to report on the clinical presentation and radiologic features of 155 cases of ameloblastoma (AB), representing a detailed, large, single-centre radiologic study.
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Comparison of diagnostic methods for detection of BRAFV600E mutation in ameloblastoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-01-07 Arularasan Anbinselvam, Abdul-Warith O. Akinshipo, Akinyele O. Adisa, Olajumoke A. Effiom, Xinhe Zhu, Kehinde E. Adebiyi, Godwin T. Arotiba, Sunday O. Akintoye
Ameloblastoma is an aggressively growing, highly recurrent odontogenic jaw tumor. Its association with BRAFV600E mutation is an indication for BRAFV00E-inhibitor therapy The study objective was to identify a sensitive low-cost test for BRAFV600E-positive ameloblastoma. We hypothesized that immunohistochemical staining of formalin-fixed paraffin-embedded tissues for BRAFV600E mutation is a low-cost
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Tertiary lymphoid structures in tongue cancer: Association with clinicopathological parameters, preoperative S-1 chemotherapy response, and prognosis J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-01-06 Mai Seki, Takaaki Sano, Emi Saito, Masaru Ogawa, Satoshi Yokoo, Tetsunari Oyama
Tertiary lymphoid structures (TLSs) are observed in cancer-invasive sites of various organs, and show evidence of tumor-specific B and/or T cells, suggesting an active humoral antitumor response. The aim of this study was to evaluate the relationship between TLSs and prognosis in patients with tongue squamous cell carcinoma (TSCC) after preoperative S-1 chemotherapy.
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Clinicopathological characteristics of odontogenic carcinosarcoma: A systematic review J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-01-01 Karoline Gomes da Silveira, Luiza de Almeida Souto Montenegro, Diana Santana de Albuquerque, Carlos Augusto Pereira do Lago, José Rodrigues Laureano Filho, Ricardo José Holanda de Vasconcellos
The aim of the present systematic review was to summarize evidence on odontogenic carcinosarcoma, analyzing clinical, epidemiological, imaging, histopathological, immunohistochemical, therapeutic, and prognostic features of this tumor.
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DNA content and clinicopathological features aid in distinguishing ameloblastic carcinoma from ameloblastoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2024-01-01 Paulo Victor Mendes Penafort, André Caroli Rocha, Fernanda Viviane Mariano, Jean Nunes dos Santos, Márcio Campos Oliveira, Pablo Agustin Vargas, Marcelo Sperandio
Ameloblastoma and ameloblastic carcinoma are epithelial odontogenic tumors that can be morphologically similar. In the present study, we evaluated the DNA content and Ki-67 index in the two tumors.
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Oral manifestations of amyloidosis and the diagnostic applicability of oral tissue biopsy J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-12-28 Thalita Soares Tavares, Adriana Aparecida Silva da Costa, Anna Luíza Damaceno Araújo, Lucas Lacerda de Souza, Maria Inês Mantuani Pascoaloti, Vanessa Fátima Bernardes, Maria Cássia Ferreira Aguiar, Pablo Agustin Vargas, Felipe Paiva Fonseca, Hélder Antônio Rebelo Pontes, Marcio Ajudarte Lopes, Alan Roger Santos-Silva, Tarcília Aparecida da Silva, Patrícia Carlos Caldeira
Amyloidosis exhibits a variable spectrum of systemic signs and oral manifestations that can be difficult to diagnose. This study aimed to characterize the clinical, demographic, and microscopic features of amyloidosis in the oral cavity.
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Antioxidant treatments in patients with oral submucous fibrosis: A systematic review J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-12-28 Martín Pérez-Leal, Federico Lanciano, Nicla Flacco, Cristina Estornut, María Carmen Carceller
Oral submucous fibrosis (OSMF) is a well-known precancerous oral lesion, characterized by scarring, tissue fibrosis, and premalignant lesions. The goal of clinical treatment is to reduce inflammation and improve patients' quality of life by enhancing mouth opening among others. Antioxidant treatment has shown promising results in inducing regression of lesions and preventing OSMF in high-risk individuals
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Calibration improves the agreement in grading oral epithelial dysplasia—Findings from a National Workshop in Malaysia J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-12-11 Thomas George Kallarakkal, Zuraiza Mohamad Zaini, Wan Maria Nabillah Ghani, Lee Peng Karen-Ng, B. S. M. S. Siriwardena, Sok Ching Cheong, Wanninayake Mudiyanselage Tilakaratne
A major pitfall of many of the established oral epithelial dysplasia (OED) grading criteria is their lack of reproducibility and accuracy to predict malignant transformation. The main objective of this study was to determine whether calibration of practicing oral pathologists on OED grading could improve the reproducibility of the WHO 2017 and the binary OED grading systems.
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Cover Image J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-11-14 Leon J. Wils, Jos B. Poell, Laura A. N. Peferoen, Ilkay Evren, Elisabeth R. Brouns, Jan G. A. M. de Visscher, Erik H. van der Meij, Ruud H. Brakenhoff, Elisabeth Bloemena
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Can a cup a day keep cancer away? A systematic review exploring the potential of coffee constituents in preventing oral squamous cell carcinoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-11-13 Jonathan Deng, Vaidehi Misra, Neehal Vilash, Wendi Wu, Cindy Hua, Kate Son, Federica Canfora, Fabian Y. S. Kong, Rita Paolini, Michael McCullough, Antonio Celentano
Coffee is one of the most consumed beverages in the world. Containing an abundance of bioactive molecules including polyphenols and flavonoids, the constituents of this beverage may exert antiproliferative, antioxidant and anti-inflammatory effects.
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FTY720 increases paclitaxel efficacy in cisplatin-resistant oral squamous cell carcinoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-11-09 Lizeth Andrea Torres Torres, Gabriel Silva, Jovelina Samara Ferreira Alves, Tatiane Resende Ushida, Julia Potenza, Cristiana Bernadelli Garcia, Lucas Oliveira Sousa, Norberto Peporine Lopes, Luciana Oliveira Almeida, Andréia Machado Leopoldino
Oral squamous cell carcinoma has high recurrence and cisplatin resistance. As cancer stem cells, autophagy, and sphingolipids have been appointed as associated with chemotherapy resistance, we tested combined treatments targeting autophagy and/or sphingolipid metabolism with paclitaxel using cisplatin-resistant oral squamous cell carcinoma cells.
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Cardiovascular diseases, risk factors, and ulcer relapse in older adults with aphthous stomatitis J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-11-06 Hui Yao, Yiwen Deng, Guanhuan Du, Yufeng Wang, Guoyao Tang
To test the hypothesis that cardiovascular diseases and risk factors are associated with ulcer relapse in after-retirement patients with recurrent aphthous stomatitis.
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ATG7-mediated autophagy protects human gingival myofibroblasts from irradiation-induced apoptosis J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-10-24 Xiumei Zhuang, Xiaoxuan Lin, Ruogu Xu, Zhengchuan Zhang, Bin Zhou, Feilong Deng
Apoptosis resistance of myofibroblasts is critical in pathology of irradiation-induced fibrosis and osteoradionecrosis of the jaw (ORNJ). However, molecular mechanism of apoptosis resistance induced by irradiation in oral myofibroblasts remains largely obscure.
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Does BRAF mutation status and related clinicopathological factors affect the recurrence rate of ameloblastoma? A systematic review, meta-analysis and metaregression J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-10-23 Ashutosh Kumar Singh, Ragavi Alagarsamy, Rajib Chaulagain, Abanish Singh, Dipak Sapkota, Selvam Thavaraj, Rabindra P. Singh
This review aims to analyse the recurrence rate in BRAFv600e+ and BRAFv600e− ameloblastomas and explore its association with clinicopathological variables.
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Oral melanoacanthoma: Clinicopathological and immunohistochemical features of a case series and a scoping review J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-10-18 Thalita Soares Tavares, Adriana Aparecida Silva da Costa, Felipe da Mata Camargos, Ricardo Santiago Gomez, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Elismauro Francisco Mendonça, Sebastião Silvério Sousa-Neto, Ana Carolina Uchoa Vasconcelos, Sandra Beatriz Chaves Tarquínio, Patrícia Carlos Caldeira
This study presents a case series and scoping review of oral melanoacanthoma to examine its clinical, histopathological, and immunohistochemical characteristics.
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Localization of beta catenin across the domain of odontogenic lesions: A systematic review J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-10-15 Shreya Chatterjee, Anju Devi, Mala Kamboj, Anjali Narwal
CTNNB1 gene encodes beta catenin, a transcriptional activator of Wnt pathway involved in the pathogenesis of odontogenic lesions. Though located intramembranously, its translocation into cytoplasm and nucleus could trigger cell proliferation, inhibition of apoptosis, invasion and migration of the tumour cell.
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Oral microbiome characterization in oral mucositis patients—A systematic review J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-10-15 Leonor Frey-Furtado, Inês Magalhães, Benedita Sampaio-Maia, Maria João Azevedo
Oral mucositis (OM) is a severe and common adverse effect of cancer treatment. The oral microbiome appears to play a role on the onset and severity of OM. Therefore, this systematic review aims to characterize the oral dysbiosis associated with OM.
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Decreased inflammatory profile in oral leukoplakia tissue exposed to cold physical plasma ex vivo J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-10-12 Christian Seebauer, Eric Freund, Tobias Dieke, Sybille Hasse, Maria Segebarth, Christoph Rautenberg, Hans-Robert Metelmann, Sander Bekeschus
Oral leukoplakia (OL) is an unfavorable oral disease often resistant to therapy. To this end, cold physical plasma technology was explored as a novel therapeutic agent in an experimental setup.
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Landscape and the immune patterns of cuproptosis in oral squamous cell carcinoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-10-12 Dong Yuan, Xin-Qiang Li, Fang-wen Qu, Yue Wang
Oral squamous cell carcinoma is an increasingly prevalent cancer type characterized by high incidence and mortality rates. Its early detection is challenging, primarily because of the absence of early molecular markers. Cuproptosis is a novel regulatory mechanism of cell death with implications in various cancers. In this study, we aimed to study cuproptosis-related genes in oral squamous cell carcinoma
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Glucose upregulates amphiregulin in oral dysplastic keratinocytes: A potential role in diabetes-associated oral carcinogenesis J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-10-10 Tao Ma, Silvia Montaner, Abraham Schneider
Compelling evidence implicates diabetes-associated hyperglycemia as a promoter of tumor progression in oral potentially malignant disorders (OPMD). Yet, information on hyperglycemia-induced cell signaling networks in oral oncology remains limited. Our group recently reported that glucose-rich conditions significantly enhance oral dysplastic keratinocyte viability and migration through epidermal growth
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Silencing of heat shock factor 1 (HSF1) inhibits proliferation, invasion, and epithelial-mesenchymal transition in oral squamous cell carcinoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-10-02 Luiz Arthur Barbosa da Silva, Lucas Melo da Costa, Ana Camila Pereira Massetti, Laudenice de Lucena Pereira, Ericka Janine Dantas da Silveira, Tuula Anneli Salo, Ricardo Della Coletta, Márcia Cristina da Costa Miguel
Oral squamous cell carcinoma is characterized by high rates of morbidity and mortality. Evidence obtained for different types of cancer shows that tumor initiation, progression, and therapeutic resistance are regulated by heat shock factor 1. This research aimed to analyze the effects of heat shock factor 1 on the biological behavior of oral squamous cell carcinoma.
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Topical medications for the treatment of recurrent aphthous stomatitis: A network meta-analysis J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-09-27 Mubarak Ahmed Mashrah, Ying Fang, Wanxing Song, Sadeq Ali Al-Maweri, Yang Lan, Ge Linhu, Liping Wang
The present network meta-analysis aims to answer the question “what is the best topical intervention for the treatment of recurrent aphthous stomatitis that can provide an acceptable pain relief and promote wound healing?”
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Identifying potential immuno-oncology targets in salivary gland mucoepidermoid carcinoma based on inflammatory status and treatment response J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-09-27 Santhosh Kumar J. Urumarudappa, Vy Ngoc Thuy Tran, Hay Mar Oo, Monthira Suntiparpluacha, Somponnat Sampattavanich, Vinicius Rosa, Komkrit Ruangritchankul, Joao N. Ferreira, Risa Chaisuparat
Mucoepidermoid carcinoma is a rare salivary gland malignant tumour. This study aimed to investigate inflammatory and immune signatures of mucoepidermoid carcinoma by identifying potential proteo-transcriptomic biomarkers towards the development of precision immuno-oncology treatment strategies.
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The role of differentiated dysplasia in the prediction of malignant transformation of oral leukoplakia J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-09-25 Leon J. Wils, Jos B. Poell, Laura A. N. Peferoen, Ilkay Evren, Elisabeth R. Brouns, Jan G. A. M. de Visscher, Erik H. van der Meij, Ruud H. Brakenhoff, Elisabeth Bloemena
Oral leukoplakia is the most common oral potentially malignant disorder. Malignant transformation of oral leukoplakia occurs at an annual rate of 1%–7%. WHO-defined classic epithelial dysplasia is an important predictor of malignant transformation of oral leukoplakia, but we have previously shown in a proof of concept study that prediction improves by incorporation of an architectural pattern of dysplasia
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Combination of downregulating FEN1 and PD-1 blockade enhances antitumor activity of CD8+ T cells against HNSCC cells in vitro J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-09-20 Xiangjian Wang, Shenjie Xu, Tao Fu, Yang Wu, Weilian Sun
Programmed cell death ligand 1 (PD-L1) and human leukocyte antigen/major histocompatibility complex (HLA/MHC) are two main kinds of immunophenotypes affecting the susceptibility to anti-PD therapy. Our previous study found that down-regulation of flap endonuclease-1 (FEN1) could not only inhibit PD-L1 expression, but also upregulate HLA expression in head and neck squamous cell carcinoma (HNSCC). We
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Editorial-Where have the last 8 years gone? J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-09-18 Peter A Brennan
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Deep learning applied to the histopathological diagnosis of ameloblastomas and ameloblastic carcinomas J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-09-15 Daniela Giraldo-Roldan, Erin Crespo Cordeiro Ribeiro, Anna Luiza Damaceno Araújo, Paulo Victor Mendes Penafort, Viviane Mariano da Silva, Jeconias Câmara, Hélder Antônio Rebelo Pontes, Manoela Domingues Martins, Márcio Campos Oliveira, Alan Roger Santos-Silva, Marcio Ajudarte Lopes, Luiz Paulo Kowalski, Matheus Cardoso Moraes, Pablo Agustin Vargas
Odontogenic tumors (OT) are composed of heterogeneous lesions, which can be benign or malignant, with different behavior and histology. Within this classification, ameloblastoma and ameloblastic carcinoma (AC) represent a diagnostic challenge in daily histopathological practice due to their similar characteristics and the limitations that incisional biopsies represent. From these premises, we wanted
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The use of deep learning state-of-the-art architectures for oral epithelial dysplasia grading: A comparative appraisal J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-09-15 Anna Luíza Damaceno Araújo, Viviane Mariano da Silva, Matheus Cardoso Moraes, Henrique Alves de Amorim, Felipe Paiva Fonseca, Maria Sissa Pereira Sant'Ana, Ricardo Alves Mesquita, Bruno Augusto Linhares Almeida Mariz, Hélder Antônio Rebelo Pontes, Lucas Lacerda de Souza, Cristina Saldivia-Siracusa, Syed Ali Khurram, Alexander T. Pearson, Manoela Domingues Martins, Marcio Ajudarte Lopes, Pablo Agustin
Dysplasia grading systems for oral epithelial dysplasia are a source of disagreement among pathologists. Therefore, machine learning approaches are being developed to mitigate this issue.
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A paradigm shift in the prevention and diagnosis of oral squamous cell carcinoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-09-14 Jan-Michaél Hirsch, Ronak Sandy, Bengt Hasséus, Joakim Lindblad
Oral squamous cell carcinoma (OSCC) is a widespread disease with only 50%–60% 5-year survival. Individuals with potentially malignant precursor lesions are at high risk.
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miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-09-14 Jijun Chen, Liang Wang, Danhua Ma, He Zhang, Jiayan Fan, Hongyan Gao, Xinyu Xia, Wei Wu, Yuyuan Shi
In this study, we aimed to investigate the potential of miR-19a as a biomarker of OSCC and its underlying molecular mechanisms.
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Prognostic significance of cyclin D1 expression pattern in HPV-negative oral and oropharyngeal carcinoma: A deep-learning approach J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-09-13 Ke Yang, Guixin Zhu, Yanan Sun, Yaying Hu, Yinan Lv, Yiwei Li, Juncheng Pan, Fu Chen, Yi Zhou, Jiali Zhang
We aimed to establish image recognition and survival prediction models using a novel scoring system of cyclin D1 expression pattern in patients with human papillomavirus-negative oral or oropharyngeal squamous cell carcinoma.
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Emerging functions and applications of exosomes in oral squamous cell carcinoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-09-13 Yingchun Qie, Xia Sun, Yongqiang Yang, Tao Yan
Oral squamous cell carcinoma is the most common phenotype in pathology, which accounts for 80% of all oral cancers. The therapeutic methods of oral squamous cell carcinoma include surgical excision, chemotherapy, and radiotherapy. Whereas, the high recurrence rate and poor prognosis lead to a 5-year survival rate less than 50%. In order to explore more therapeutic strategies of oral squamous cell carcinoma
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Elevated translationally controlled tumour protein promotes oral cancer progression and poor outcome J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-08-13 Dipti Sharma, Sagar N. Pawar, Prasad Sulkshane, Rohit Waghole, Mohd Yasser, Sushil S. Pawar, Sadhana Kannan, Nazia Chaudhary, Anjali Kalwar, Rahul Patil, Sudhir Nair, Sorab N. Dalal, Tanuja Teni
Translationally controlled tumour protein (TCTP) is a multifunctional protein elevated in multiple cancers. However, studies on its role in oral carcinogenesis and prognosis are rare. We recently reported the role of its interacting partner, MCL1, in oral cancer progression and outcome. Hence, the present study aimed to assess TCTP expression in oral tumorigenesis and its association with patient outcomes
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An exotic pathogenetic mechanism of angiogenesis in oral lichen planus—A systematic review J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-08-08 R. Keerthika, Mala Kamboj, Akhil Girdhar, Anjali Narwal, Anju Devi, Rahul Anand, Manish Juneja
Angiogenesis plays a vital role at the molecular level in various inflammatory lesions, that lead to their chronicity. Oral lichen planus is an immune-mediated chronic inflammatory disorder. The angiogenetic role and exact mechanisms in oral lichen planus are still unclear due to a dearth of studies. Its clinical significance with angiogenesis also requires further elucidation necessitating a thorough
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PTCH/SMO gene mutations in odontogenic keratocysts and drug interventions J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-08-08 Shan Wang, Yingying Hong, Jiafei Qu, Jianyun Zhang, Yuhao Zhang, Jiemei Zhai, Tiejun Li
Odontogenic keratocysts (OKCs) are odontogenic jaw lesions that cause destruction and dysfunction of the jawbone. OKCs can be sporadic or associated with nevoid basic cell carcinoma syndrome (NBCCS). However, the factors that initiate OKCs and the mechanism of cyst formation remain unclear. Here, we investigated the impact of PTCH1 and SMO mutations on disease progression, as well as the effects of
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Dexamethasone solution and dexamethasone in Mucolox™ for the treatment of oral inflammatory ulcerative diseases: A phase II randomized clinical trial J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-08-07 Michele Lodolo, Burinrutt Thanasuwat, Piri Veluppillai, Gus Bassani, Alessandro Villa
Mucolox™ is a mucosal drug delivery system that prolongs the contact time between the oral mucosa and topical corticosteroids, potentially reducing the need for multiple applications daily. This study aimed to assess the clinical efficacy and tolerability of dexamethasone 0.5 mg/5 mL solution in Mucolox™ for the management of oral inflammatory ulcerative diseases.
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MiRNAs that target amyloid precursor protein processing machinery in extracellular vesicles and particles derived from oral squamous cells carcinoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-08-07 Fernando Galvão, Michele Patricia Rode, Paloma Santos de Campos, Gisele Eva Bruch, Virgínia Mendes Carregal, André Ricardo Massensini, Bibiana Franzen Matte, Marcelo Lazzaron Lamers, Tânia Beatriz Creczynski-Pasa, Ionara Rodrigues Siqueira
Considering that microRNAs (miRNAs), extracellular vesicles and particles (EVPs) and the amyloid precursor protein (APP) processing have been shown to be altered in oral squamous cells carcinoma (OSCC), it is possible that miRNAs that target APP processing pathways in EVPs are impacted in tumor cells. Our aim was to evaluate miRNAs that target APP itself or disintegrin and metalloproteinase domain
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Single-cell RNA sequencing reveals tumor heterogeneity within salivary gland pleomorphic adenoma: A preliminary study J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-08-07 Xi-Qian Wang, Nian-Nian Zhong, Qi-Wen Man, Guang-Cai Xu, Si-Chen Yan, Li-Wei Peng, Yong-Gong Wang, Bing Liu, Lin-Lin Bu, Li Li
Salivary gland pleomorphic adenoma (SPA) is a common neoplasm of salivary glands that displays remarkable histological diversity. Previous studies have demonstrated the involvement of gene rearrangements and cytoskeleton-remodeling-related myoepithelial cells in SPA tumorigenesis. Cytoskeleton remodeling is necessary for epithelial-mesenchymal transition (EMT), a key process in tumor progression. However
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Differential expression of PEA3 in odontogenic cysts and tumors J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-08-07 Khin Mya Tun, Nakarin Kitkumthorn, Dusit Bumalee, Tawepong Arayapisit, Puangwan Lapthanasupkul
PEA3 transcription factor has been identified as a downstream target of the MAPK and PI3K pathways, and PEA3 overexpression has been observed in a variety of tumor types. We aimed to evaluate PEA3 expression in odontogenic cysts and tumors and compare the expression among odontogenic lesions. In addition, the correlations between PEA3 expression and clinicopathological characteristics of conventional
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High expression of novel biomarker TBRG4 promotes the progression and invasion of oral squamous cell carcinoma J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-08-03 Abilasha Ramasubramanian, Pratibha Ramani, Balachander Kannan, Paramasivam Arumugam
Transforming growth factor β regulator 4 (TBRG4) is a potential prognostic indicator in various cancers, especially squamous cell carcinomas, and is associated with disease amelioration and poor outcomes. The study aimed to assess the expression pattern of TBRG4 in patients with operable oral squamous cell carcinoma (OSCC) to understand its role in tumour progression using indicators of disease outcome
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The ability of the eighth edition of the TNM staging system plus minor invasion criteria to predict the biological behaviour of oral cavity carcinomas J. Oral Pathol. Med. (IF 3.3) Pub Date : 2023-08-01 Giuseppe Perlangeli, Giovanni Lilloni, Giulia Salti, Andrea Ferri, Silvano Ferrari, Tito Poli
Oral squamous cell carcinoma (OSCC) treatment is based largely on the TNM stage. The eighth edition includes important new prognostic parameters (extranodal extension and depth of invasion), while it does not consider tumour molecular characteristics or minor invasion criteria (perineural and lymphovascular invasion, grading and resection margins). This study evaluated how well the TNM eighth edition