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The impact of bone grafting with/without barrier membrane placement on the outcome of apical surgery: A systematic review and meta-analysis Int. Endod. J (IF 5.0) Pub Date : 2024-03-16 Richard Flynn, Federico Foschi, Brian Maloney, Greg Creavin, Henry F. Duncan
Regenerative techniques are increasingly being advocated in endodontic apical surgery (AS) to enhance the healing of periapical lesions. Various grafting and membrane materials are employed as adjuncts to modern AS.
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Prevalence and virulence factors of haemolytic Enterococcus faecalis isolated from root filled teeth associated with periradicular lesions: A laboratory investigation in Thailand Int. Endod. J (IF 5.0) Pub Date : 2024-03-14 Kewalin Thammasitboon, Rawee Teanpaisan, Nuntiya Pahumunto
Previous endodontic research has provided limited understanding of the prevalence and roles of haemolytic and non-haemolytic Enterococcus faecalis strains in root filled teeth. This study aimed to determine the prevalence of these strains in root filled teeth with periradicular lesions and investigate their associated virulence factors.
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In-depth investigation of FAM20A insufficiency effects on deciduous dental pulp cells: Altered behaviours, osteogenic differentiation, and inflammatory gene expression Int. Endod. J (IF 5.0) Pub Date : 2024-03-13 Kanokwan Sriwattanapong, Thanakorn Theerapanon, Chompak Khamwachirapitak, Pannagorn Sae-ear, Noppadol Sa-Ard-Iam, Vorasuk Shotelersuk, Thantrira Porntaveetus
Loss-of-function mutations in FAM20A result in amelogenesis imperfecta IG (AI1G) or enamel-renal syndrome, characterized by hypoplastic enamel, ectopic calcification, and gingival hyperplasia, with some cases reporting spontaneous tooth infection. Despite previous reports on the consequence of FAM20A reduction in gingival fibroblasts and transcriptome analyses of AI1G pulp tissues, suggesting its involvement
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Influence of dental bleaching on the pulp tissue: A systematic review of in vivo studies Int. Endod. J (IF 5.0) Pub Date : 2024-03-12 Mariana Viana Donato, Alexandre Henrique dos Reis-Prado, Lucas Guimarães Abreu, Lara Cancella de Arantes, Juliana Goto, Hebertt Gonzaga dos Santos Chaves, Luciano Tavares Angelo Cintra, André Luiz Fraga Briso, Isabella Faria da Cunha Peixoto, Francine Benetti
Although several studies indicate the harmful effects of bleaching on pulp tissue, the demand for this procedure using high concentrations of hydrogen peroxide (HP) is high.
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Biocompatibility and bioactive potential of NeoPUTTY calcium silicate-based cement: An in vivo study in rats Int. Endod. J (IF 5.0) Pub Date : 2024-03-11 Evelin Carine Alves Silva, Jéssica Arielli Pradelli, Guilherme Ferreira da Silva, Paulo Sérgio Cerri, Mario Tanomaru-Filho, Juliane Maria Guerreiro-Tanomaru
To evaluate the inflammatory reaction and the ability to induce mineralization activity of a new repair material, NeoPUTTY (NPutty; NuSmile, USA), in comparison with Bio-C Repair (BC; Angelus, Brazil) and MTA Repair HP (MTA HP; Angelus, Brazil).
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Anti-inflammatory cerium-containing nano-scaled mesoporous bioactive glass for promoting regenerative capability of dental pulp cells Int. Endod. J (IF 5.0) Pub Date : 2024-03-04 Yiyuan Duan, Kai Zheng, Wenzhu Hu, Jake Jinkun Chen, Xiaolin Lu, Mingxin Wang, Yuxin Yang, Jingyao Guo, Yanlai Lu, Qian Ma
This study aimed to investigate the anti-inflammatory and odontoblastic effects of cerium-containing mesoporous bioactive glass nanoparticles (Ce-MBGNs) on dental pulp cells as novel pulp-capping agents.
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Editor-in-Chief thanks the associate editors, editorial board and referees Int. Endod. J (IF 5.0) Pub Date : 2024-03-06 Henry F. Duncan
On behalf of the Editor-in-Chief and the editorial team in Wiley, I would like to thank those who have contributed to the continued success of the IEJ in 2023. I would like to start by acknowledging and thanking the Associate Editors for their outstanding contribution during the year and their ongoing support to me as Editor-in-Chief: Sebastian Bürklein, Gustavo De-Deus, Ikhlas El-karim, Michael Hülsmann
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New associate editor for case reports and launch of opinion/perspective articles Int. Endod. J (IF 5.0) Pub Date : 2024-03-06 Henry F. Duncan
New associate editor for case reports and opinion/perspective Prof. Zhi Chen. As part of the continued evolution of the Editorial Board to reflect current trends in submission and publication in the journal, the International Endodontic Journal is delighted to announce the appointment of a new Associate Editor Professor Zhi Chen who will be responsible for case reports and opinion/perspective articles
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Harnessing antimicrobial peptides in endodontics Int. Endod. J (IF 5.0) Pub Date : 2024-03-05 Xinzi Kong, Vijetha Vishwanath, Prasanna Neelakantan, Zhou Ye
Endodontic therapy includes various procedures such as vital pulp therapy, root canal treatment and retreatment, surgical endodontic treatment and regenerative endodontic procedures. Disinfection and tissue repair are crucial for the success of these therapies, necessitating the development of therapeutics that can effectively target microbiota, eliminate biofilms, modulate inflammation and promote
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Nlrp3 inflammasome drives regulatory T cell depletion to accelerate periapical bone erosion Int. Endod. J (IF 5.0) Pub Date : 2024-03-05 Konghuai Wang, Jiayi Liu, Junli Yue, Lu Zhou, Hanqing Mao, Jiaqi Li, Zhijun Sun, Zhi Chen, Lu Zhang
Apical periodontitis is an inflammatory disorder triggered by an immune response to bacterial infection, leading to the periapical tissue damage and alveolar resorption. However, the underlying mechanisms driving this process remain elusive, due to the complex and interconnected immune microenvironment within the local lesion site. In this study, the influence of Nlrp3 inflammasome-mediated immune
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Ginsenoside Rb1 alleviates lipopolysaccharide-induced inflammation in human dental pulp cells via the PI3K/Akt, NF-κB, and MAPK signalling pathways Int. Endod. J (IF 5.0) Pub Date : 2024-03-04 Ok Hyung Nam, Jae-Hwan Kim, Si Won Kang, Yong Kwon Chae, Myeong-Kwan Jih, Hyekyoung Hannah You, Jeong-Tae Koh, Young Kim
Among numerous constituents of Panax ginseng, a constituent named Ginsenoside Rb1 (G-Rb1) has been studied to diminish inflammation associated with diseases. This study investigated the anti-inflammatory properties of G-Rb1 on human dental pulp cells (hDPCs) exposed to lipopolysaccharide (LPS) and aimed to determine the underlying molecular mechanisms.
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Endodontics in the Metaverse: Exploring new Frontiers Int. Endod. J (IF 5.0) Pub Date : 2024-03-04 Shima Saber Tahan, Ove A. Peters, Mehran Farajollahi
CONFLICT OF INTEREST STATEMENT The authors deny any conflicts of interest.
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Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization Int. Endod. J (IF 5.0) Pub Date : 2024-02-27 Yuqiang Wang, Jiakang Zhu, Ying Tang, Cui Huang
This current Mendelian randomization (MR) study aims to comprehensively explore the potential bidirectional link between pulp and periapical disease (PAP) with type 2 diabetes mellitus (T2DM).
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The clinical outcomes of vital intact teeth close to large cystic lesions of endodontic origin: A prospective clinical study Int. Endod. J (IF 5.0) Pub Date : 2024-02-27 Francesco Erovigni, Ilaria Bosso, Mario Alovisi, Luca Mela, Lorenzo Bianchi, Ilaria Bobba, Giuseppe Migliaretti, Caterina Chiara Bianchi, Damiano Pasqualini
To evaluate the indication of the endodontic treatment for vital intact teeth with the root apex involved in large radicular cystic lesions of endodontic origin.
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STING inhibition alleviates bone resorption in apical periodontitis Int. Endod. J (IF 5.0) Pub Date : 2024-02-27 Han-Qing Mao, Lu Zhou, Jia-Qi Li, Yuan-Hao Wen, Zhi Chen, Lu Zhang
The goal of this study was to investigate the potential effects of an immunotherapeutic drug targeting STING to suppress the overreactive innate immune response and relieve the bone defect in apical periodontitis.
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The effect of root canal preparation tapers on planktonic bacteria and biofilm reduction in the apical third: A correlative microtomography and microbiological laboratory study Int. Endod. J (IF 5.0) Pub Date : 2024-02-25 Fernanda Piffer Garcia Macedo, Adriana de Jesus Soares, Marília Fagury Videira Marceliano-Alves, Elizabeth Martinez, Ricardo Lopes, Luan Ferreira Bastos, Wayne Martins Nascimento, Ana Grasiela Limoeiro, Marcos dos Frozoni
To evaluate the influence of different preparation tapers on the reduction in planktonic bacteria and biofilms of Enterococcus faecalis and Candida albicans in the apical third (4 mm) of the mesial roots of mandibular molars, correlating decontamination with canal shape.
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Nanoparticulate bioceramic putty suppresses osteoclastogenesis and inflammatory bone loss in mice via inhibition of TRAF6-mediated signalling pathways: A laboratory investigation Int. Endod. J (IF 5.0) Pub Date : 2024-02-25 Zijun Wang, Jie Zhang, Xiaoyue Sun, Jingjing Yu, Bingqian Liu, Bin Peng, Li Wang, Jingwen Yang, Lingxin Zhu
This study aimed to determine the effects of iRoot BP Plus on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis in vitro and inflammation-mediated bone resorption in vivo and investigated the underlying molecular mechanisms.
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Effect of supplementary sodium hypochlorite agitation techniques on an ex vivo oral multispecies biofilm during passive disinfection of simulated immature roots Int. Endod. J (IF 5.0) Pub Date : 2024-02-22 Walbert de Oliveira Vieira, Adriana de-Jesus-Soares, Erica M. Lopes, Brenda P. F. A. Gomes, Bruno P. Lima
To compare the effect of different sodium hypochlorite (NaOCl) agitation techniques on an ex vivo oral multispecies biofilm during passive disinfection of simulated immature roots.
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Multimethod analysis of large- and low-tapered single file reciprocating instruments: Design, metallurgy, mechanical performance, and irrigation flow Int. Endod. J (IF 5.0) Pub Date : 2024-02-20 Emmanuel João Nogueira Leal Silva, Fernando Peña-Bengoa, Natasha C. Ajuz, Victor T. L. Vieira, Jorge N. R. Martins, Duarte Marques, Ricardo Pinto, Mario Rito Pereira, Francisco Manuel Braz-Fernandes, Marco A. Versiani
To compare eight large- and low-tapered heat-treated reciprocating instruments regarding their design, metallurgy, mechanical properties, and irrigation flow through an in silico model.
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Investigation of the early apical release from endodontic hydrogels: A 3D printed model Int. Endod. J (IF 5.0) Pub Date : 2024-02-20 Marianne Leveque, Mourad Bekhouche, Jean-Christophe Farges, Raphaël Richert, Maxime Ducret
Regenerative Endodontic Procedures (REPs) using new materials such as hydrogels aim to replace current endodontic treatments, but numerous limitations are to overcome. Apical release was little explored in previous studies, especially regarding hydrogels that incorporate molecules, such as growth factors and antibiotics. Apical release is a key mechanism in achieving regeneration, as it could regulate
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Efficacy of the GentleWave System in the removal of biofilm from the mesial roots of mandibular molars before and after minimal instrumentation: An ex vivo study Int. Endod. J (IF 5.0) Pub Date : 2024-02-19 Kwang Ho Kim, Céline Lévesque, Gevik Malkhassian, Bettina Basrani
To compare the efficacy of Enterococcus faecalis biofilm removal using the GentleWave System (GWS) (Sonendo Inc, CA) on non-instrumented versus minimally instrumented root canal systems.
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Calcium hydroxide-loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament Int. Endod. J (IF 5.0) Pub Date : 2024-02-19 Xavier Roig, Lyda Halbaut, Firas Elmsmari, Rubén Pareja, Aizea Arrien, Fernando Duran-Sindreu, Luis María Delgado, Marta Espina, María Luisa García, José Antonio González Sánchez, Elena Sánchez-López
Design, produce and assess the viability of a novel nanotechnological antibacterial thermo-sensible intracanal medicament This involves encapsulating calcium hydroxide (Ca(OH)2) within polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) and dispersing them in a thermosensitive gel (Ca(OH)2-NPs-gel). In addition, perform in vitro and ex vivo assessments to evaluate tissue irritation and penetration
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Identification of keystone taxa in root canals and periapical lesions of post-treatment endodontic infections: Next generation microbiome research Int. Endod. J (IF 5.0) Pub Date : 2024-02-15 Maria Teresa Arias-Moliz, Virginia Pérez-Carrasco, David Uroz-Torres, Jose Domingo Santana Ramos, Jose Antonio García-Salcedo, Miguel Soriano
The aim of this study was to analyse and compare the microbiome present in root canals and periapical lesions of teeth with post-treatment infections, and to identify the presence of keystone taxa in both habitats using next-generation sequencing analysis.
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Next-generation antibacterial nanopolymers for treating oral chronic inflammatory diseases of bacterial origin Int. Endod. J (IF 5.0) Pub Date : 2024-02-10 Manuel Toledano-Osorio, Raquel Osorio, Jaime Bueno, Cristina Vallecillo, Marta Vallecillo-Rivas, Mariano Sanz
‘Periodontitis’ refers to periodontal destruction of connective tissue attachment and bone, in response to microorganisms forming subgingival biofilms on the root surface, while ‘apical periodontitis’ refers to periapical inflammatory processes occurring in response to microorganisms within the root canal system. The treatment of both diseases is based on the elimination of the bacterial challenge
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Principle and antimicrobial efficacy of laser-activated irrigation: A narrative review Int. Endod. J (IF 5.0) Pub Date : 2024-02-10 Maarten Meire, Roeland J. G. De Moor
In the last two decades, the activation of root canal irrigants with pulsed lasers as an adjunct in root canal treatment has become increasingly popular. This narrative review explains the physical basics and the working mechanism of laser-activated irrigation (LAI), explores the parameters influencing LAI efficacy, considers historical evolutions in the field and summarizes laboratory and clinical
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PDGF-AA guides cell crosstalk between human dental pulp stem cells in vitro via the PDGFR-α/PI3K/Akt axis Int. Endod. J (IF 5.0) Pub Date : 2024-02-09 Siqun Xu, Jieya Wei, Yang Liu, Li Zhang, Mengmeng Duan, Jiazhou Li, Zhixing Niu, Xiaohua Pu, Minglei Huang, Hao Chen, Xuedong Zhou, Jing Xie
To explore the influence of PDGF-AA on cell communication between human dental pulp stem cells (DPSCs) by characterizing gap junction intercellular communication (GJIC) and its potential biomechanical mechanism.
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Vital pulp therapy—Factors influencing decision-making for permanent mature teeth with irreversible pulpitis: A systematic review Int. Endod. J (IF 5.0) Pub Date : 2024-02-07 Yasmen Alfaisal, Ghassan Idris, Ove A. Peters, Sobia Zafar, Venkateshbabu Nagendrababu, Christine I. Peters
There is an increased tendency towards adopting minimally invasive interventions in dentistry, supported by advancement in materials and techniques. However, the decision-making process in choosing conservative or invasive treatments is influenced by several factors, particularly in permanent teeth with irreversible pulpitis.
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Final irrigation with bioglass solution in regenerative endodontic procedure induces tissue formation inside the root canals, collagen maturation, proliferation cell and presence of osteocalcin Int. Endod. J (IF 5.0) Pub Date : 2024-02-07 Kiani dos Santos de Paula, Alexandre Henrique dos Reis-Prado, Witalo Pereira de Jesus, Juliana Goto, Lara Cancella de Arantes, Marina Verçosa, Luciano Tavares Angelo Cintra, Edilson Ervolino, Raphael Escorsim Szawka, Murilo Camuri Crovace, Ricardo Alves de Mesquita, Francine Benetti
To evaluate the influence of an experimental solution of cobalt-doped F18 bioactive glass (F18Co) on tissue repair following regenerative endodontic procedure (REP) in rat molars.
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A 22-year follow-up cross-sectional study on periapical health in relation to the quality of root canal treatment in a Belgian population Int. Endod. J (IF 5.0) Pub Date : 2024-02-05 Georgios Keratiotis, Loukia Spineli, Mieke A. A. De Bruyne, Roeland J. G. De Moor, Maarten A. Meire
To investigate the prevalence of apical periodontitis (AP) and the technical standard of root canal treatment in a Belgian population, assess the association of different variables with periapical status, and compare the results to a similar study conducted 22 years previously.
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Vital root resection with radicular retrograde partial pulpotomy in furcation-involved maxillary molars in patients with periodontitis: Technique description and case series considering clinical and economic aspects Int. Endod. J (IF 5.0) Pub Date : 2024-02-02 Antonio Ciardo, Sarah Rampf, Ti-Sun Kim
Conventional root resection in periodontally compromised furcation-involved maxillary molars requires preceding endodontic treatment and is therefore associated with loss of tooth vitality, higher invasiveness, treatment time and costs, and the risk of endodontic complications. Vital root resection (VRR) could overcome these disadvantages while establishing stable periodontal and endodontic conditions
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Substance P/calcitonin gene-related peptide and their receptors expression in human periodontal ligament after root canal preparation with five different systems Int. Endod. J (IF 5.0) Pub Date : 2024-01-31 Javier Caviedes-Bucheli, Hernan Dario Muñoz-Alvear, Luis Fernando Lopez-Moncayo, Kranthi Raja Kacharaju, Adriana Carolina Velasquez-Rivera, Luis Alberto Carlosama-Recalde, Juan Camilo Pazmiño, Jose Francisco Gomez-Sosa, Luis Eduardo Diaz-Barrera, Hugo Roberto Munoz
The purpose of this study was to quantify the effect of five different root canal preparation instruments on Substance P (SP), Calcitonin gene-related peptide (CGRP) and their receptors expression in healthy human periodontal ligament.
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Effect of preemptive use of a nonsteroidal anti-inflammatory drug and a corticosteroid on the efficacy of inferior alveolar nerve blockade and postoperative pain control in endodontic treatment of molars with symptomatic pulpitis: A randomized double-blind placebo-controlled clinical trial Int. Endod. J (IF 5.0) Pub Date : 2024-01-27 Guilherme Araujo Rodrigues, Ruy Hizatugu, Juliana Delatorre Bronzato, Adriana de-Jesus-Soares, Marcos Frozoni
The anaesthetic success rate of an inferior alveolar nerve block (IANB) in mandibular molars with irreversible symptomatic pulpitis can be low, and postoperative pain control in teeth with this diagnosis can be challenging. This study aimed to evaluate the influence of preemptive use of dexamethasone and oral potassium diclofenac on the success of IANB. The influence of these drugs on the intensity
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Osteopontin interacts with dendritic cells and macrophages in pulp inflammation: Comprehensive transcriptomic analysis and laboratory investigations Int. Endod. J (IF 5.0) Pub Date : 2024-01-27 Leyi Chen, Mingqi Zhu, Chuhan Zhang, Ziting Wang, Xiaolin Lyu, Wenan Xu, Buling Wu
To investigate novel diagnostic markers for pulpitis and validate by clinical samples from normal and inflamed pulp. To explore the relationship between diagnostic markers and immune cells or their phenotypes during pulp inflammation.
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Rev-erbα attenuates refractory periapical periodontitis via M1 polarization: An in vitro and in vivo study Int. Endod. J (IF 5.0) Pub Date : 2024-01-27 W. Song, L. Ye, Q. Tang, X. Lu, X. Huang, M. Xie, S. Yu, Z. Yuan, L. Chen
Rev-erbα has been reported to regulate the healing of inflammatory lesions through its effect on the immune system in a variety of inflammatory disease. Moreover, the balance of macrophages polarization plays a crucial role in immune response and inflammatory progression. However, in refractory periapical periodontitis (RAP), the role of Rev-erbα in inflammatory response and bone resorption by regulating
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A video-based decision aid improved knowledge and decreased decisional conflict for asymptomatic persistent endodontic lesions Int. Endod. J (IF 5.0) Pub Date : 2024-01-22 Mingrun Wei, Shaoyong Tan, Peter Tsao Pan Yu, Thomas Kvist, Victoria Soo Hoon Yu
This prospective cohort study aimed to (i) evaluate patients' treatment decisions, decisional conflict and knowledge levels before and after use of a video-based decision aid (DA) on asymptomatic persistent endodontic lesions (APEL) and to (ii) elicit important decision factors for patients in the decision-making process.
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Reduced C-reactive protein levels after root canal treatment in clinically healthy young apical periodontitis individuals at cardiovascular risk. A prospective study Int. Endod. J (IF 5.0) Pub Date : 2024-01-20 Mauricio Garrido, María José Bordagaray, Catalina Schweitzer, Joaquín Lucero-Mora, Montserrat Reyes, Elizabeth Pellegrini, Patricia Hernández-Ríos, Alejandra Fernández, Marcela Hernández
To determine the systemic inflammatory burden, including hsCRP and its monomeric forms, in patients with apical lesions of endodontic origin treated with root canal treatment (RCT).
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Dynamically guided transantral piezoelectric endodontic microsurgery: A case report with technical considerations Int. Endod. J (IF 5.0) Pub Date : 2024-01-20 Paula Andrea Villa-Machado, Felipe Augusto Restrepo-Restrepo, Sergio Iván Tobón-Arroyave
Endodontic microsurgery (EMS) of maxillary molars may represent a complex challenge to the clinician due to the location of the roots and the proximity of the maxillary sinus floor. This report aimed to describe the simultaneous use of a computer-assisted dynamic navigation (C-ADN) system and piezoelectric bony-window osteotomy for the transantral microsurgical approach of a maxillary left first molar
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Factors associated with the outcome of root canal treatment—A cohort study conducted in a private practice Int. Endod. J (IF 5.0) Pub Date : 2024-01-20 Rok Jurič, G. Vidmar, R. Blagus, Janja Jan
To investigate the association of various pre-, intra- and post-operative factors on root canal treatment outcome.
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Circ-ZNF236 mediates stem cells from apical papilla differentiation by regulating LGR4-induced autophagy Int. Endod. J (IF 5.0) Pub Date : 2024-01-19 Ya Xiao, Luyao Chen, Yunlong Xu, Ruiyang Yu, Jiamin Lu, Yue Ke, Rong Guo, Tingjie Gu, Haowen Yu, Yuxin Fang, Zehan Li, Jinhua Yu
Human stem cells from the apical papilla (SCAPs) are an appealing stem cell source for tissue regeneration engineering. Circular RNAs (circRNAs) are known to exert pivotal regulatory functions in various cell differentiation processes, including osteogenesis of mesenchymal stem cells. However, few studies have shown the potential mechanism of circRNAs in the odonto/osteogenic differentiation of SCAPs
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Effect of final irrigation protocols with chitosan nanoparticle and genipin on dentine against collagenase degradation: An ex-vivo study Int. Endod. J (IF 5.0) Pub Date : 2024-01-19 S. N. Şengül, S. Ozturk, K. Ulubayram, N. Pekel Bayramgil, S. Kucukkaya Eren
Endodontic irrigants may affect the mechanical and chemical properties of dentine. This study evaluated the effects of various final irrigation protocols including the use of chitosan nanoparticle (CSnp) and cross-linking with genipin on the (1) mechanical and (2) chemical properties of dentine against enzymatic degradation.
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TLR2 agonist prevents the progression of periapical lesions in mice by reducing osteoclast activity and regulating the frequency of Tregs Int. Endod. J (IF 5.0) Pub Date : 2024-01-18 Lana Kei Yamamoto Almeida, Ricardo Anibal Battaglino, Lisa Danielly Curcino Araujo, Marília Pacífico Lucisano, Vivian Vicentin Massoni, Léa Assed Bezerra da Silva, Paulo Nelson-Filho, Leslie Rae Morse, Raquel Assed Bezerra da Silva
To evaluate the role of regulatory T lymphocytes (Tregs) in the presence or absence of the synthetic ligand Pam3Cys during the progression of periapical lesion in wild-type (WT) and toll-like receptor 2 knockout (TLR2KO) mice.
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The use of medicaments in the management of symptomatic irreversible pulpitis: A community-based cohort study Int. Endod. J (IF 5.0) Pub Date : 2024-01-12 David Edwards, Sabrina Rasaiah, Lise-Lotte Kirkevang, Michael Vaeth, Simon J. Stone, Ilona Obara, Justin Durham, John Whitworth
To investigate patient outcomes from either pulpotomy or pulpectomy for the management of symptomatic irreversible pulpitis, with and without application of antibiotic/corticosteroid pastes in urgent primary dental care settings in the United Kingdom.
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Radiographic outcome of endodontic treatment and retreatment of teeth with apical periodontitis using two different root canal irrigants. A prospective cohort study Int. Endod. J (IF 5.0) Pub Date : 2024-01-11 Erik Katle, Homan Zandi, Deniz Pedersen, Pia Titterud Sunde, Gerald R. Torgersen, Dag Ørstavik
The aim of this prospective cohort study was to compare the radiographic outcome of endodontic treatment and retreatment of teeth with apical periodontitis using either 1% sodium hypochlorite (NaOCl) or 2% chlorhexidine digluconate (CHX) for root canal irrigation.
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Association between apical periodontitis and secondary outcomes of atherosclerotic cardiovascular disease: A case–control study Int. Endod. J (IF 5.0) Pub Date : 2024-01-10 Giulia Malvicini, Crystal Marruganti, Mustafa Abu Leil, Marco Martignoni, Edoardo Pasqui, Gianmarco de Donato, Simone Grandini, Carlo Gaeta
To evaluate the association between apical periodontitis (AP) and atherosclerotic cardiovascular disease (ASCDV).
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The IL-1β-p65 axis stimulates quiescent odontogenic epithelial cell rests via TGF-β signalling to promote cell proliferation of the lining epithelia in radicular cysts: A laboratory investigation Int. Endod. J (IF 5.0) Pub Date : 2024-01-10 Ryoko Nagano, Yusuke Nakako, Shinsuke Fujii, Shintaro Kawano, Hidefumi Maeda, Tamotsu Kiyoshima
Cyst formation of the jaws is frequently accompanied by the proliferation of odontogenic epithelial cells located in the periodontal ligament (PDL), which consists of heterozygous cells and includes the most fibroblasts. The lining epithelium of radicular cyst, an odontogenic cyst of inflammatory origin, is derived from the proliferation of the remnants of the Hertwig epithelial root sheath (odontogenic
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A laboratory study comparing the static navigation technique using a bur with a conventional freehand technique using ultrasonic tips for the removal of fibre posts Int. Endod. J (IF 5.0) Pub Date : 2024-01-10 Francesc Abella Sans, Zeena Tariq Alatiya, Gonzalo Gómez Val, Venkateshbabu Nagendrababu, Paul Michael Howell Dummer, Fernando Durán-Sindreu Terol, Juan Gonzalo Olivieri
There are currently no high-quality studies comparing the static navigation technique with conventional methods of fibre post removal. The aim of this ex vivo study was to compare the effectiveness of fibre post removal between a static navigation technique and a conventional freehand technique using ultrasonics by experienced and inexperienced operators.
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Abstracts Int. Endod. J (IF 5.0) Pub Date : 2024-01-02
R001 Determination of the optimal bucco-palatal position of the endodontic access cavity in maxillary central incisors R Hellyn, M De Bruyne, R de Moor, M Meire Section of Endodontology, Department of Oral Health Sciences, Ghent University, Ghent, Belgium Aim: To determine the optimal bucco-palatal location of the access cavity in upper central incisors, and to assess the influence of age and incisal
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Author Index Int. Endod. J (IF 5.0) Pub Date : 2024-01-02
Abella, F. R108 Abiad, R. R029, R033 Ahmed, F. R109 Akıncı, L. R032 Al Ghamdi, S. R005 Al Himairi, S. R006 Al Munaifi, N. R067 Al Othman, S. R054 Al Qahtani, O. R085 Al-Jadaa, A. R030 Al-Omari, T. R066 Alaraj, D. R094 Albadri, S. R012 Albahary, S. R100 Albashaireh, K. R101 Alencar, D. R128 Alfuraih, N. R059 AlHwaizi, H. R104 Ali, F. R044 Allihaibi, M. R058 Alluhaidan, S. R017 Almasri, M. R023, R088
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An international consensus study to identify “what” outcomes should be included in a core outcome set for endodontic treatments (COSET) for utilization in clinical practice and research Int. Endod. J (IF 5.0) Pub Date : 2023-12-27 Ikhlas El Karim, Henry Fergus Duncan, Siobhan Cushley, Venkateshbabu Nagendrababu, Lise-Lotte Kirkevang, Casper Lemvig Kruse, Bun San Chong, Pratik Kamalkant Shah, Mark Lappin, Fionnuala T. Lundy, Mike Clarke
Development of a standardized set of topic-specific outcomes known as a Core Outcome Set (COS) is important to address issues of heterogeneity in reporting research findings in order to streamline evidence synthesis and clinical decision making.
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Validity and reliability of artificial intelligence chatbots as public sources of information on endodontics Int. Endod. J (IF 5.0) Pub Date : 2023-12-20 Hossein Mohammad-Rahimi, Seyed AmirHossein Ourang, Mohamad Amin Pourhoseingholi, Omid Dianat, Paul Michael Howell Dummer, Ali Nosrat
This study aimed to evaluate and compare the validity and reliability of responses provided by GPT-3.5, Google Bard, and Bing to frequently asked questions (FAQs) in the field of endodontics.
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Viability and oxidative stress of dental pulp cells after indirect application of chemomechanical agents: An in vitro study Int. Endod. J (IF 5.0) Pub Date : 2023-12-18 Caio Luiz Lins-Candeiro, Luiz Renato Paranhos, Nilson Ferreira de Oliveira Neto, Rafael Antônio Oliveira Ribeiro, Carlos Alberto de-Souza-Costa, Fernanda Rodrigues Guedes, Washington Henrique Themoteo da Silva, Ana Paula Turrioni, Paulo César de Freitas Santos Filho
This study evaluated the transdentinal cytotoxic effects of enzymatic agents (EA) for chemomechanical carious tissue removal on human dental pulp cells.
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A critical look at outcome measures: Comparison between four dental research journals by use of a hierarchical model Int. Endod. J (IF 5.0) Pub Date : 2023-12-11 Linnéa Wrangstål, Maria Pigg, Nawaf Almutairi, Helena Fransson
To assess the status quo of outcome measures used in treatment studies in Endodontics, and potentially identify strategies for improvement, by (i) systematically assessing the outcome measures using a conceptual model and (ii) comparing these with measures used in corresponding studies in the adjacent fields.
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Advancing insights in contemporary endodontics: Proposing a multimethod approach for comprehensive evaluation of NiTi instruments Int. Endod. J (IF 5.0) Pub Date : 2023-12-10 Emmanuel João Nogueira Leal Silva, Jorge N. R. Martins, Marco Aurélio Versiani
CONFLICT OF INTEREST STATEMENT The authors declare that they have no competing interests with regard to this paper.
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Effects of N-acetyl-L-cysteine against apical periodontitis in rats with adriamycin-induced cardiomyopathy and nephropathy Int. Endod. J (IF 5.0) Pub Date : 2023-12-09 Ahmet Özer Şehirli, Umut Aksoy, Abdullah Sibai, Kaan Orhan, Serkan Sayıner
This study aimed to investigate the potential protective effects of N-acetyl-L-cysteine (NAC) against apical periodontitis (AP) in rats with adriamycin (ADR)-induced kidney and heart diseases.
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Dental and endodontic-related stress amongst undergraduate students before and during the COVID-19 pandemic: A mixed-methods study Int. Endod. J (IF 5.0) Pub Date : 2023-12-06 Valérie Chevalier, Anaïs Le Fur Bonnabesse, B. Honari, H. F. Duncan
To determine and explain the principal sources of stress among preclinical and clinical dental undergraduate students with a particular focus on the stressors linked to endodontics.
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Prevalence of apical periodontitis and non-retention of root-filled teeth in hypertensive patients: Systematic review and meta-analysis Int. Endod. J (IF 5.0) Pub Date : 2023-12-05 Daniel Cabanillas-Balsera, Victoria Areal-Quecuty, Cristiane Cantiga-Silva, Carolina de Barros Morais Cardoso, Luciano Tavares Angelo Cintra, Jenifer Martín-González, Juan J. Segura-Egea
Several studies have suggested a relationship between AP, as well as the loss of root-filled teeth (RFT), and hypertension (HTN).
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Guanylate-binding protein 5-mediated cell-autonomous immunity suppresses inflammation in dental pulpitis: An in vitro study Int. Endod. J (IF 5.0) Pub Date : 2023-12-05 Minchun Huang, Chaoning Zhan, Bo Yang, Yanli Lu, Xiaojun Yang, Jin Hou
Guanylate-binding protein 5 (GBP5) is an interferon (IFN)-inducible GTPase that plays a crucial role in the cell-autonomous immune response against microbial infections. In this study, we investigated the immunoregulatory role of GBP5 in the pathogenesis of dental pulpitis.
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The effect of ultrasonic and multisonic irrigation on root canal microbial communities: An ex vivo study Int. Endod. J (IF 5.0) Pub Date : 2023-11-20 Ki Hong Park, Ronald Ordinola-Zapata, W. Craig Noblett, Bruno P. Lima, Christopher Staley
To analyse the effect of ultrasonic irrigant activation (UIA) and the GentleWave (GW) multisonic irrigation (GW) with minimal instrumentation on the root canal microbial diversity in an ex vivo model that used extracted molars with a history of pulp necrosis.
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Predictors of periapical bone healing associated with teeth having large periapical lesions following nonsurgical root canal treatment or retreatment: A cone beam computed tomography-based retrospective study Int. Endod. J (IF 5.0) Pub Date : 2023-11-17 Carolina Mosquera-Barreiro, Manuel Ruíz-Piñón, Francesc Abella Sans, Venkateshbabu Nagendrababu, Thilla Sekar Vinothkumar, Jenifer Martín-González, Benjamín Martín-Biedma, Pablo Castelo-Baz
Several factors influence the condition of the periapical tissues associated with root filled teeth. The primary objective of this study was to retrospectively evaluate the extent and speed of bone healing of large periapical lesions associated with nonsurgical root canal treatment or retreatment. The secondary objective was to analyse the relationship between the time to complete healing when analysed
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IWP-2 modulates the immunomodulatory properties of human dental pulp stem cells in vitro Int. Endod. J (IF 5.0) Pub Date : 2023-11-16 Ajjima Chansaenroj, Chatvadee Kornsuthisopon, Ravipha Suwittayarak, Sunisa Rochanavibhata, Lai-Keng Loi, Yu-Cheng Lin, Thanaphum Osathanon
To investigate the effect of IWP-2, Wnt inhibitor, on human dental pulp stem cells (hDPSCs) responses.