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Depth of invasion to the bladder wall as a prognostic factor and its association with circulating cell-free DNA levels in patients with muscle-invasive bladder cancer. Curr. Urol. Pub Date : 2023-11-03 Yusuke Iemura,Makito Miyake,Shinji Fukui,Tomomi Fujii,Sayuri Ohnishi,Shunta Hori,Yosuke Morizawa,Yasushi Nakai,Kazumasa Torimoto,Nobumichi Tanaka,Kiyohide Fujimoto
Background Radical cystectomy (RC) is the standard surgical treatment for patients with muscle-invasive bladder cancer, but the prognosis is not favorable, and new prognostic factors need to be discovered. We investigated the potential of depth of invasion (DOI) as a prognostic factor in patients with muscle-invasive bladder cancer who underwent RC. Furthermore, we examined the association between
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Patient-derived bladder cancer organoid model to predict sensitivity and feasibility of tailored precision therapy. Curr. Urol. Pub Date : 2023-07-20 Ying Jiang,Xun Sun,Xiaoyun Song,Zhen Li,Ping Zhang,Wen Zhang,Dongqi Tang
Background Bladder cancer is a common and highly heterogeneous malignant tumor with a relatively poor prognosis. Thus, personalized treatment strategies for bladder cancer are essential for improving patient outcomes. Materials and methods We developed an efficient 3-dimensional in vitro organoid culture system for bladder cancer organoids (BCOs), which maintains the homology with the original patient
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Construction and evaluation of a novel prognostic risk model of aging-related genes in bladder cancer. Curr. Urol. Pub Date : 2023-07-12 Delin Wang,Hao Ning,Haihu Wu,Yufeng Song,Yaru Chu,Feifan Liu,Zhenlin Zhao,Fei Wu,Jiaju Lyu
Background Bladder cancer (BLCA) is the most common malignancy of the urinary system. Muscle-invasive bladder cancer (MIBC), which constitutes approximately 25% of all BLCA cases, is characterized by frequent recurrence and early onset of metastasis. Bladder cancer most commonly occurs in elderly patients and is significantly associated with aging. However, the prognostic value of age-related genes
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Can magnetic resonance imaging differentiate muscle invasion (T2) and lamina propria invasion (T1) urothelial carcinoma of the bladder? A systematic review and meta-analysis of Vesical Imaging-Reporting and Data System accuracy. Curr. Urol. Pub Date : 2023-06-24 Seyed Behzad Jazayeri,Hojat Dehghanbanadaki,Mahdie Hosseini,Pourya Taghipour,Michael W Bacchus,Elizabeth A Di Valerio,Elnaz Sarabchian,K C Balaji,Mark Bandyk
Background Vesical Imaging-Reporting and Data System (VI-RADS) was developed as a structured reporting tool to anticipate the possibility of muscle invasion. This study is aimed to investigate the diagnostic accuracy of VI-RADS for discriminating T2 from T1 bladder cancer. Materials and methods Scopus, Web of Science, PubMed, and Embase were searched on October 4, 2021, for studies with the following
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Miniaturizing the approach to upper tract renal calculi: Is smaller always better? A narrative review. Curr. Urol. Pub Date : 2023-06-08 Daniel Da Silva Ferreira,Amit Satish Bhattu,Ahmed Adam
Newer modalities for treating upper tract urinary stones focus on maintaining and improving outcomes, reducing complications, and optimizing patient care. This narrative review aims to outline novel miniaturized endourological innovations for managing upper tract calculi.
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A novel technique for unilateral dissection of the penile neurovascular bundle to prevent loss of penile sensation during treatment of Peyronie's disease-Initial results of a pilot study. Curr. Urol. Pub Date : 2023-06-08 Alexandr M Pinkhasov,Matthew Beamer,Daniel Shulman,Rachel Yakubov,Esther Pinkhasov,Sergey Kravchick
Background Plaque incision/excision and grafting are surgical techniques used to treat patients with Peyronie's disease who are refractory to less invasive interventions, have severe penile curvature, or have an hourglass deformity. However, the procedure carries the risk of penile sensory loss because of the need for dissection of the neurovascular bundle (NVB). The aim of this study was to assess
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Enfortumab vedotin and pembrolizumab as monotherapies and combination treatment in locally advanced or metastatic urothelial carcinoma: A narrative review. Curr. Urol. Pub Date : 2023-05-05 Maria A Bantounou,Josip Plascevic,Lewis MacDonald,Man Chun Wong,Neasa O'Connell,Helen F Galley
Background Bladder cancer is the 10th most common cancer globally. The majority of bladder cancers are urothelial carcinomas (UCs), which, if locally advanced or metastatic, carry poor long-term prognosis. Cancer cells can evade the immune system by expressing the programmed cell death ligand 1 protein (PD-L1). Programmed cell death ligand 1 protein binds to programmed cell death protein 1 (PD-1) on
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Comparative evaluation of urolithiasis management options in patients with horseshoe kidney: A systematic review and meta-analysis. Curr. Urol. Pub Date : 2023-05-05 Yazan Qaoud,Merella Al Tali,Fiona Boland,Andrew Simpson,Niall Davis
Background Horseshoe kidney is a rare congenital anomaly commonly complicated by urolithiasis. Extracorporeal shockwave lithotripsy (ESWL), ureteroscopy (URS), and percutaneous nephrolithotomy (PCNL) are treatment options for horseshoe kidney stones. The aim of this systematic review is to compare the benefits and risks of these management options. Methods MEDLINE, EMBASE, and Cochrane Library databases
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Difference in symptom manifestation between postmenopausal and premenopausal women in acute uncomplicated cystitis: A multi-institutional pilot study. Curr. Urol. Pub Date : 2023-04-01 Atsushi Wanifuchi,Yuki Kyoda,Takuto Ogasawara,Ko Kobayashi,Naoki Ito,Tetsuya Shindo,Atsushi Takahashi,Yasuharu Kunishima,Naoya Masumori
Objectives We aimed to prospectively compare lower urinary tract symptoms in premenopausal and postmenopausal women with acute uncomplicated cystitis before and after antibiotic therapy. Materials and methods This study included adult women with acute uncomplicated cystitis who visited 4 institutions between 2019 and 2020. After registration, we administered oral antibiotics and prospectively documented
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The spectrum and etiologies of lower urinary tract symptoms in postmenopausal women. Curr. Urol. Pub Date : 2023-03-28 Vishrut Bharti,Rajesh K Tiwari,Sanjay Gupta,Rohit Upadhyay,Manoj K Singh,Deelip K Singh
Background Although the prevalence of lower urinary tract symptoms (LUTS) is high in the female population, it is even higher in postmenopausal females. The frequency, severity, and etiology of LUTS vary among populations and individuals. This study aimed to define the characteristics of LUTS in postmenopausal women and their underlying etiologies. Material and methods Overall, 74 postmenopausal patients
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The association between postvoid residual and response to standard therapy in male and female patients with non-muscle-invasive bladder cancer. Curr. Urol. Pub Date : 2023-03-26 Luca Di Gianfrancesco
Background The urinary retention is recognized as a promoting factor for bladder cancer, but its role as prognostic factor of therapeutic response has not yet been widely considered. To correlate bladder outlet characteristics with short-term response to treatment in non-muscle-invasive bladder cancer. Materials and methods We carried out a case-control study on 600 consecutive patients with a first
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A comparison of visual discomfort experienced by surgeons in wireless versus conventional endoscopy in laparoscopic surgery. Curr. Urol. Pub Date : 2023-03-23 Hanjiang Xu,Di Niu,Cheng Yang,Zongyao Hao,Chaozhao Liang
Background This study was performed to introduce a new wireless endoscopic system. Research and development were based on fifth-generation transmission technology. Eye symptoms and visual discomfort induced by the novel endoscopic system were compared with those induced by the conventional endoscopic system before and during laparoscopic pelvic surgery. Materials and methods Twenty surgeons successfully
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Ureteroscopy during pregnancy under local anesthesia and light sedation: Technique and video. Curr. Urol. Pub Date : 2023-03-16 Patrick Juliebø-Jones,Christian Beisland,Peder Gjengstø,Rachel Maheswaran,Øyvind Ulvik
Ureteroscopy during pregnancy has become increasingly recognized as a safe intervention. Performing it under local anesthesia and light sedation reduces the risks associated with general or regional anesthesia, such as difficult airway scenarios, hypothermia, and hypotension. In addition, this approach reduces the total amount of fetal exposure to medications and anesthetic agents. Performing ureteroscopy
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Revolutionizing laparoscopic telesurgery: The emergence of 5G-assisted wireless endoscopy systems. Curr. Urol. Pub Date : 2023-03-15 Guiting Lin,Tom F Lue
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Modern methods in managing urachal adenocarcinoma. Curr. Urol. Pub Date : 2023-03-11 Samih Taktak,Omar El-Taji,Vishwanath Hanchanale
Objectives We sought to evaluate modern diagnostic and treatment options for urachal adenocarcinoma (UAC) and to provide clarity regarding the available options and their outcomes for this poorly understood yet damaging disease. Material and methods We conducted a systematic literature search in PubMed and Medline focusing on updated management of UAC. Results Surgical intervention continues to be
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A radiation-related second primary gastrointestinal stromal tumor in the bladder. Curr. Urol. Pub Date : 2023-03-03 Mai Hori,Kazuki Maki,Yumiko Okuno,Koji Mikami,Takumi Takeuchi
A 69-year-old man underwent 78 Gy/39 Fr of intensity-modulated radiation therapy for prostate cancer. Seven years after radiotherapy, a nonpapillary bladder tumor was identified. Transurethral resection of the bladder tumor was performed, and the pathological diagnosis was spindle cell sarcoma. Immunostaining revealed KIT-, DOG1++, CD34-, Actin++, Cytokeratin-, Desmin-, S100 protein-, and Vimentin++
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Invited commentary: Comparison of visual discomfort experienced by surgeons in wireless versus conventional endoscopy in laparoscopic surgery. Curr. Urol. Pub Date : 2023-03-03 José Ignacio Nolazco
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A rare triple concurrence of ureteric calculus and renal cell carcinoma in a horseshoe kidney. Curr. Urol. Pub Date : 2023-02-16 Kale Munien,Joshua Winston,Nicholas Davies
Horseshoe kidney is a rare anatomical variant with low clinical morbidity. However, the characteristic shape of horseshoe kidney causes significant anomalies within the vascular and collecting systems. This complicates the diagnosis and management of coexisting pathologies within the kidneys. Here, we report a rare case of concurrent diagnoses of ipsilateral ureteric calculus and renal cell carcinoma
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Effects of lemon-tomato juice consumption on crystal formation in the urine of patients with calcium oxalate stones: A randomized crossover clinical trial. Curr. Urol. Pub Date : 2023-01-29 Sathish K Gopala,Jim Joe,Jithesh Chandran
Background Dietary supplementation with citrate-containing juices may serve as an effective alternative to potassium citrate therapy for preventing calcium oxalate stone recurrence. This study was performed to evaluate whether consumption of lemon-tomato juice can decrease the tendency for stone formation in the urine of calcium oxalate stone formers. Materials and methods The study was conducted as
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Clinical and prostate multiparametric magnetic resonance imaging findings as predictors of general and clinically significant prostate cancer risk: A retrospective single-center study. Curr. Urol. Pub Date : 2023-01-14 Matteo Massanova,Rebecca Vere,Sophie Robertson,Felice Crocetto,Biagio Barone,Lorenzo Dutto,Imran Ahmad,Mark Underwood,Jonathan Salmond,Amit Patel,Giuseppe Celentano,Jaimin R Bhatt
Background To evaluate the predictive values of Prostate Imaging Reporting and Data System version 2 (PI-RADS v2), prostate-specific antigen (PSA) level, PSA density (PSAD), digital rectal examination findings, and prostate volume, individually and in combination, for the detection of prostate cancer (PCa) in biopsy-naive patients. Methods We retrospectively analyzed 630 patients who underwent transrectal
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Metabolic evaluation of first-time uncomplicated renal stone formers: A prospective study. Curr. Urol. Pub Date : 2022-12-13 Satish Kumar Ranjan,Ankur Mittal,Anissa Atif Mirza,Sunil Kumar,Vikas Kumar Panwar,Shivcharan Navriya,Arup Kumar Mandal,Kim Jacob Mammen
Background Nephrolithiasis is a global health problem. The recurrence rate after the first stone clearance is approximately 50% at 5 years. Metabolic abnormalities are an important factor responsible for stone recurrence. Our prevalidated study aimed to evaluate metabolic abnormalities associated with first-time uncomplicated renal stone formers (FTURSF). Materials and methods In this prospective,
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Predictors of time-to-nadir serum creatinine after drainage of bilaterally obstructed kidneys due to bladder cancer. Curr. Urol. Pub Date : 2022-11-16 Rabea Ahmed Gadelkareem,Ahmed Mahmoud Abdelraouf,Abdelfattah Ibrahim Ahmed,Ahmed Mohammed El-Taher,Hosny Mahmoud Behnsawy
Background There are persistent controversies about the outcomes and benefits of drainage of malignant ureteral obstruction by percutaneous nephrostomy (PCN). This study aimed to assess the predictors of the time-to-nadir (TTN) of serum creatinine (SCr) levels after drainage of bilaterally obstructed kidneys (BOKs) due to bladder cancer (BC) by PCN. Materials and methods This prospective nonrandomized
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Assessment of the efficacy of reduced-radiation noncontrast computed tomography scan compared with the standard noncontrast computed tomography scan for detecting urolithiasis: A prospective single-center study. Curr. Urol. Pub Date : 2022-11-07 Gaurav Aggarwal,Samiran Das Adhikary
Background Noncontrast computed tomography (CT) scan of the kidneys, ureter and bladder is the standard investigative modality for diagnosing and following up patients with urolithiasis. With each scan, a patient receives radiation of 18-34 mGy. Dose considerations become pertinent because of a 10% lifetime incidence rate and higher than 50% risk of recurrence, necessitating repeated imaging in the
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Periurethral abscess etiology, risk factors, treatment options, and outcomes: A systematic review. Curr. Urol. Pub Date : 2022-10-12 Arsalan Tariq,Adam G Stewart,Devang J Desai,Sumudu Britton,Nigel Dunglison,Rachel Esler,Matthew J Roberts
Objectives This study aimed to describe patterns of presentation, etiology, risk factors, management, and treatment outcomes of periurethral abscesses using a systematic review framework. Materials and methods After prospective registration on the PROSPERO database (CRD42020193063), a systematic review of Web of Science, Embase, PubMed, and Cochrane scientific databases was performed. Articles published
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Current laser therapy options for endoscopic treatment of upper tract urothelial carcinoma. Curr. Urol. Pub Date : 2022-10-10 Benjamin W Zollinger,Ezra J Shoen,Charles F Gresham,Michael J Whalen
Endoscopic management via retrograde ureteroscopic laser ablation of upper tract urothelial carcinoma (UTUC) has become the preferred treatment modality for low-risk tumors. The most popular ablative lasers over the past 15-20 years have been the holmium:yttrium-aluminum-garnet (Ho:YAG) and neodymium (Nd:YAG) lasers, but recently the thulium (Th:YAG) laser has emerged as a potential alternative. This
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Ureteroscopy during pregnancy: Outcomes and lessons learned over 4 decades at a tertiary center in Norway. Curr. Urol. Pub Date : 2022-10-08 Patrick Juliebø-Jones,Christian Beisland,Peder Gjengstø,Stephen Baug,Øyvind Ulvik
Background The management of suspected kidney stone disease in pregnancy is challenging. In cases of persistent flank pain and where investigations may have rendered equivocal results, ureteroscopy (URS) is a recognized diagnostic and therapeutic intervention. This study aimed to investigate the safety and outcomes associated with performing URS during pregnancy, as the technique has evolved over the
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A retrospective analysis of the factors associated with increased risk of readmission within 30 days after primary transurethral resection of bladder tumor. Curr. Urol. Pub Date : 2022-09-28 Tarun Jindal,Ankush Sarwal,Prateek Jain,Rajan Koju,Satyadip Mukherjee
Background Transurethral resection of bladder tumor (TURBT) is associated with perioperative morbidity of 5% to 10%, which can lead to unplanned readmissions. In this study, we aimed to identify the factors that lead to an increased risk of unplanned readmissions within 30 days of primary TURBT. Materials and methods A retrospective study was conducted to identify patients who underwent primary TURBT
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Pelviureteric junction obstruction in adults: A systematic review of the literature. Curr. Urol. Pub Date : 2022-09-28 Niall J O'Sullivan,Steven Anderson
Background Pelviureteric junction obstruction (PUJO) is a common urological disorder that can present at any stage of life. The underlying etiology in children has been well studied; however, a gap exists in the literature for the adult population. Herein, we performed a systematic review of the literature to evaluate the current evidence on the underlying etiologies of adult patients presenting with
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Laser speckle contrast imaging compared with indocyanine green in renal perfusion of a porcine model. Curr. Urol. Pub Date : 2022-09-28 Jonathan Noël,Anya Mascarenhas,Chibueze A Nwaiwu,Yao Liu,Marcio Moschovas,Vasiliy E Buharin,John Oberlin,Saloni Mehrotra,Alyson F Dechert,Peter C W Kim,Vipul Patel
Background When viewed under near-infrared light, indocyanine green (ICG) signal for kidney perfusion can be utilized in partial nephrectomy. Laser speckle contrast imaging (LSCI) uses coherent light to detect perfusion during real-time laparoscopic surgery. Materials and methods Laser speckle contrast imaging or ActivSight, an imaging sensor adapter, was used during laparoscopy of an anesthetized
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The efficacy and safety of one-stage endoscopy combined with intrarenal surgery (mini-nephrostomy tract) in the prone split-leg position for complex renal calculi. Curr. Urol. Pub Date : 2022-09-16 Kai Yu,Zhebin Du,Hanqing Xuan,Yang Cao,Hai Zhong,Fangzhou Li,Qi Chen
Background The goal of this study was to determine the safety and efficacy of endoscopic combined intrarenal surgery (ECIRS) performed in the prone split-leg position for the treatment of complex renal stones. Materials and methods A mature ECIRS protocol was designed. Retrospective analysis was conducted of medical records between January 2020 and December 2021 of patients with complex renal stones
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Predictors of stone-free rate after a single-session extracorporeal shockwave lithotripsy for a single kidney stone measuring 10 to 20 mm: A private center experience. Curr. Urol. Pub Date : 2022-09-16 Amr A Faddan,Osama Najieb,Rabea A Gadelkareem
Background Despite the continuous update of guidelines for the management of kidney stones, the ability to predict a successful response to extracorporeal shockwave lithotripsy (SWL) remains a topic of research. This is due to the need to refine the decision making in the context of technological advancements and current pandemics. This study aimed to determine the predictors of stone-free rate (SFR)
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The unique landscape of coronavirus disease 2019 coagulopathy and imminent bleedings at unusual sites: Pathophysiology matters. Curr. Urol. Pub Date : 2022-09-16 Eleni Paschou,Achilleas Betsikos,Georgios Zagkotsis,Nikolaos Sabanis
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Vitamin D receptor polymorphism and prostate cancer prognosis. Curr. Urol. Pub Date : 2022-09-16 Ahmed Z El-Attar,Samia Hussein,Mariam F A Salama,Hanaa M Ibrahim,Amira S AlKaramany,Mansour K Elsawi,Mohamed Hemeda,Ahmed Algazeery
Background Prostatic epithelial cells synthesize the active form of vitamin D (1,25-dihydroxyvitamin D3), which participates in regulating prostate growth. Calcitriol, a synthetic form of vitamin D3, exhibits antiproliferative and prodifferentiation activities in prostate cancer. The function of 1,25-dihydroxyvitamin D3 is mediated by its binding to vitamin D receptor (VDR). VDR forms a heterodimer
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Selecting lymph node-positive patients for adjuvant therapy after radical prostatectomy and extended pelvic lymphadenectomy: An outcome analysis of 100 node-positive patients managed without adjuvant therapy. Curr. Urol. Pub Date : 2022-09-09 Ashwin Sunil Tamhankar,Saurabh Patil,Shanky Singh,Danny Darlington Carbin,Smruti Mokal,Puneet Ahluwalia,Gagan Gautam
Objective The aim of the study is to evaluate the effect of deferred androgen deprivation therapy on biochemical recurrence (BCR) and other survival parameters in node-positive prostate cancer patients after robot-assisted radical prostatectomy with bilateral extended pelvic lymph node dissection (RARP + EPLND). Materials and methods Of the 453 consecutive RARP procedures performed from 2011 to 2018
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Comparison of survival outcomes between laparoscopic versus open radical nephroureterectomy in upper tract urothelial cancer patients: Experiences of a tertiary care single center. Curr. Urol. Pub Date : 2022-08-31 Benedikt Hoeh,Marina Kosiba,Mike Wenzel,Nicola Meister,Felix Preisser,Shahrokh F Shariat,Jan Lukas Hohenhorst,Andreas Becker,Philipp Mandel,Severine Banek,Frederik Roos,Pierre I Karakiewicz,Felix K H Chun,Luis A Kluth
Objectives To test for differences in overall and recurrence-free survival between laparoscopic and open surgical approaches in patients undergoing radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Materials and methods We retrospectively identified patients treated for UTUC from 2010 to 2020 from our institutional database. Patients undergoing laparoscopic or open RNU with
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Aquablation in men with benign prostate hyperplasia: A systematic review and meta-analysis. Curr. Urol. Pub Date : 2022-08-31 David C Chen,Liang Qu,Howard Webb,Kirby Qin,Bodie Chislett,Alan Xue,Sari Khaleel,Manuel De Jesus Escano,Eric Chung,Ahmed Adam,Damien Bolton,Marlon Perera
Objective The aim of the study is to investigate improvements in lower urinary tract symptoms in men with benign prostatic hyperplasia (BPH) treated with prostatic Aquablation. Materials and methods We performed a literature search of clinical trials using the MEDLINE, Embase, and Cochrane Library databases and retrieved published works on Aquablation for the treatment of BPH up to August 2021. Unpublished
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Primary testicular lymphoma: Clinical characteristics and oncological outcomes. Curr. Urol. Pub Date : 2022-08-31 Alberto Artiles Medina,Javier Lorca Álvaro,Irene Carretero Del Barrio,Inés Laso García,Mónica García Cosío,Marina Mata Alcaraz,Manuel Hevia Palacios,Victoria Gómez Dos Santos,Francisco Javier Burgos Revilla
Background Primary testicular lymphoma (PTL) is a rare testicular malignancy, despite being considered the most common testicular tumor in patients older than 60 years. Primary testicular lymphoma represents only 1%-9% of testicular neoplasms. Few studies have been published regarding its clinical features and management. This study aimed to analyze the clinical characteristics and outcomes of PTL
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Prevalence of pelvic floor disorders and the associated quality of life among institutionalized and noninstitutionalized elderly women: A cross-sectional study. Curr. Urol. Pub Date : 2022-08-31 Heloisa da Costa Souza,Lívia M T Pires,Gláucia C Vieira,Edna A B Castro,Elaine A Moura,Júlia Engelmann,Diogo S Fonseca
Background An increase in life expectancy has led to an increased elderly population. In turn, this aging population is more likely to develop health conditions, such as pelvic floor disorders (PFDs). This study aimed to assess the prevalence of these disorders and the associated quality of life in institutionalized and noninstitutionalized elderly women. Materials and methods A cross-sectional study
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An independent practice validation of the Prostate Imaging Reporting and Data System version 2 scoring system and the introduction of PDP (prostate-specific antigen density × PI-RADSv2) score to assist with further risk assessment. Curr. Urol. Pub Date : 2022-08-31 Parth U Patel,David Bock,Christian A Hettinger
Objectives To provide concise information to clinicians on how to better interpret multiparametric magnetic resonance imaging for prostate cancer risk stratification. Materials and methods We analyzed 2 separate cohorts. For patients receiving a Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) score of 1 or 2, we reviewed the charts of 226 patients who underwent multiparametric magnetic
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Prostate cancer screening: Continued controversies and novel biomarker advancements. Curr. Urol. Pub Date : 2022-08-31 Atiyah Tidd-Johnson,Sneha Annie Sebastian,Edzel Lorraine Co,Munaza Afaq,Hansini Kochhar,Mona Sheikh,Arpit Mago,Sujan Poudel,John A Fernandez,Ivan D Rodriguez,Sanjay Razdan
Prostate cancer (PCa) screening remains one of the most controversial topics in clinical and public health. Despite being the second most common cancer in men worldwide, recommendations for screening using prostate-specific antigen (PSA) are unclear. Early detection and the resulting postscreening treatment lead to overdiagnosis and overtreatment of otherwise indolent cases. In addition, several unwanted
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Ductal prostate cancer: Clinical features and outcomes from a multicenter retrospective analysis and overview of the current literature. Curr. Urol. Pub Date : 2022-08-31 Salvatore Cozzi,Lilia Bardoscia,Masoumeh Najafi,Sefik Igdem,Luca Triggiani,Stefano Maria Magrini,Andrea Botti,Ferran Guedea,Laura Melocchi,Patrizia Ciammella,Cinzia Iotti,Cristina Gutierrez
Objective The aim of the study is to evaluate clinical features and outcomes after different therapeutic strategies for ductal prostate adenocarcinoma (DPC), a rare but aggressive subtype of invasive prostate cancer (PCa) accounting for, in the pure and mixed form, 1% or less and 5% or less, respectively, of all the newly diagnosed PCa. Materials and methods Patients with a proven diagnosis of DPC
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Androgen receptor signaling-mitochondrial DNA-oxidative phosphorylation: A critical triangle in early prostate cancer. Curr. Urol. Pub Date : 2022-08-31 Minas Sakellakis,Laura Jacqueline Flores
Mitochondria are more than just the cellular powerhouse. They also play key roles in vital functions such as apoptosis, metabolism regulation, and other intracellular interactions. The mitochondrial DNA (mtDNA) encodes for 12 subunits of the oxidative phosphorylation (OXPHOS) system. Depletion of mtDNA in androgen-dependent prostate cancer (PCa) cell lines renders them androgen-independent and more
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Single tertiary cancer center experience on the management of pT3b prostate cancer after robotic-assisted laparoscopic prostatectomy. Curr. Urol. Pub Date : 2022-08-31 Arvind Nayak,Omar El-Taji,Sugeeta Sukumar,John Piedad,Aruni Ghose,Rob Hughes,Roberto Alonzi,Peter Ostler,Anand Sharma,Tim Lane,Jim Adshead,Nikhil Vasdev
Background Pathological involvement of the seminal vesicle poses a treatment dilemma following robotic prostatectomy. Margin status plays an important role in deciding further management. A wide range of treatment options are available, including active monitoring, adjuvant radiotherapy, salvage radiotherapy, and occasionally androgen deprivation therapy. Patients undergoing postoperative radiotherapy
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Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients. Curr. Urol. Pub Date : 2022-08-31 Antonio Benito Porcaro,Nelia Amigoni,Riccardo Rizzetto,Filippo Migliorini,Alessandro Tafuri,Pierluigi Piccoli,Leone Tiso,Mario De Michele,Alberto Bianchi,Sebastian Gallina,Paola Irene Ornaghi,Rossella Orlando,Francesco Cianflone,Alessandra Gozzo,Stefano Zecchini Antoniolli,Vincenzo Lacola,Matteo Brunelli,Maria Angela Cerruto,Walter Artibani,Alessandro Antonelli
Objectives To test hypothesized associations between the ABO blood group (ABO-bg) system and the pathological features of prostate cancer (PCa). Material and methods Between January 2013 and September 2019, 1173 patients underwent radical prostatectomy. Associations between ABO-bg levels and pathological features were evaluated using statistical methods. Results Overall, 1149 consecutive patients were
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Determining the component-based operative time learning curve for robotic-assisted radical prostatectomy. Curr. Urol. Pub Date : 2022-08-31 David Ambinder,Shu Wang,Mohummad Minhaj Siddiqui
Objectives To determine the learning curve (LC) of total operative time and the discrete components of the robotic-assisted radical prostatectomy (RARP) for a recent robotic fellowship-trained urologic surgeon. Materials and methods We performed a retrospective analysis of RARP procedures performed by a single new attending surgeon from August 2015 to April 2019. Patients' demographics and operative
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Role of multiparametric magnetic resonance imaging in the diagnosis and staging of urinary bladder cancer. Curr. Urol. Pub Date : 2022-08-31 Essam A Shalaby,Ahmed R Mohamed,Tarek H Elkammash,Rasha T Abouelkheir,Ahmed M Housseini
Objectives To assess the role of multiparametric magnetic resonance imaging (mp-MRI) in the diagnosis and staging of urinary bladder cancer (BC). Materials and methods Fifty patients diagnosed with bladder masses underwent mp-MRI study. The results of 3 image sets were analyzed and compared with the histopathological results as a reference standard: T2-weighted image (T2WI) plus dynamic contrast-enhanced
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Complete transurethral resection of bladder tumor before radical cystectomy is not a risk factor for organ-confined bladder cancer: A case-control study. Curr. Urol. Pub Date : 2022-08-27 Xiaoxu Yuan,Mingkun Chen,Jing Yang,Yunlin Ye
Objectives To investigate the role of complete transurethral resection of bladder tumor (TURBT) before radical cystectomy (RC) for organ-confined bladder cancer. Materials and methods Data of patients who underwent RC in our center from January 2008 to December 2018 were retrospectively reviewed. Patients with >T2N0M0 disease and positive surgical margins and those who received neoadjuvant/adjuvant
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How to reduce bacillus Calmette-Guérin discontinuation in patients with severe functional impairment. Curr. Urol. Pub Date : 2022-08-27 Luca Di Gianfrancesco,Mauro Ragonese,Massimiliano Foti,Giuseppe Palermo,Emilio Sacco,PierFrancesco Bassi,Marco Racioppi
Background Severe functional impairment is often considered a contraindication to intravesical therapy for nonmuscle-invasive bladder cancer (NMIBC). A tailored intravesical bacillus Calmette-Guérin (BCG) procedure was evaluated in high-risk (HR)-NMIBC patients with severe functional impairment. Materials and methods Patients with a Katz Index score of 2 or less and an initial diagnosis of HR-NMIBC
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The era of personalized treatments: Updates on immunotherapy within urothelial of bladder cancer. Curr. Urol. Pub Date : 2022-08-27 Zhang-Song Wu,Song Wu
Bladder cancer is a complex disease of the urinary system with high morbidity and mortality. Recently, the introduction of immunotherapies such as immune checkpoint inhibitors (eg, programmed cell death protein 1/programmed death-ligand 1) has proven to be a reliable means of improving survival outcomes, including patients with limited response to conventional treatment. Nevertheless, difficult questions
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Reconstruction of the male external genitalia in diverse disease processes: Our reconstructive algorithm, techniques, and experience. Curr. Urol. Pub Date : 2022-08-27 Stefanie M Croghan,Caroline Kelly,Anne E Daniels,Linda Fitzgibbon,Pádraig J Daly,Ivor M Cullen
Background Male genital form and function may be rendered abnormal by a number of disease processes, with profound associated psychological and functional consequences. The aim of the study is to review our reconstructive experience with cases of genital loss or distortion due to nonmalignant diseases processes and atypical neoplasia. Materials and methods A retrospective review of a prospectively
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The use of blue-light cystoscopy in the detection and surveillance of nonmuscle invasive bladder cancer. Curr. Urol. Pub Date : 2022-08-27 Ellen M Cahill,Kevin Chua,Sai Krishnaraya Doppalapudi,Saum Ghodoussipour
Nonmuscle invasive bladder cancer is associated with a high risk of recurrence as well as progression to muscle-invasive disease. Therefore, adequate visualization and identification of malignant lesions as well as complete resection are critical. Traditional white-light cystoscopy is limited in its ability to detect bladder cancer, specifically carcinoma in situ. Blue-light cystoscopy makes use of
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Antimicrobial susceptibility of bacteria isolated from urine cultures in Southern Turkey. Curr. Urol. Pub Date : 2022-08-27 Caner Baran,Akif Küçükcan
Background Pathogen spectrum and antibiotic susceptibility patterns vary in different regions and should consider the empirical treatment of urinary tract infections (UTIs). Information on susceptibility is the basis for providing reliable treatment. This study aimed to determine the antibiotic susceptibility of bacteria isolated from urine cultures at Çukurova State Hospital, which is located south
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Clinical characteristics and treatment outcomes of patients with small cell carcinoma of the urinary bladder. Curr. Urol. Pub Date : 2022-08-27 Takashi Muranaka,Kohei Hashimoto,Tetsuya Shindo,Kosuke Shibamori,Yuki Kyoda,Ko Kobayashi,Toshiaki Tanaka,Naoya Masumori
Background Small cell carcinoma of the urinary bladder (SCUB) is rare. The optimal treatment for SCUB remains unclear. To address the problem of appropriate treatment for each case, we assessed single-modality and surgery-based multimodality treatments in patients with SCUB. Materials and methods We retrospectively reviewed the medical records of 12 patients with SCUB between 1990 and 2013. All patients
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The indispensable role of urinalysis for patients undergoing treatment for nonmuscle invasive bladder cancer. Curr. Urol. Pub Date : 2022-08-27 Luca Di Gianfrancesco,Mauro Ragonese,Giuseppe Palermo,Emilio Sacco,Foschi Nazario,PierFrancesco Bassi,Marco Racioppi
Despite several efforts in the search for noninvasive biomarkers to provide prognostic information for noninvasive muscle bladder cancer, none have shown significant potential. In this context, standard urinalysis is still necessary to provide many data. This method is an inexpensive, simple, and easy-to-repeat tool to follow-up patients over time. Urinalysis does not fall within study protocols and
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Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma. Curr. Urol. Pub Date : 2022-08-22 Yaohai Wu,Shiqiang Zhang,Chujie Chen,Jun Pang
Increasing evidence indicates that N6-methyladenosine (m6A) methylation modification serves important functions in biological metabolism. Dysregulation of m6A regulators is related to the progression of different malignancies, including renal cell carcinoma (RCC). Recent studies have reported preliminary findings on the influence of m6A regulator dysregulation on RCC tumorigenesis and development.
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Learning curve for magnetic resonance imaging/ultrasound fusion prostate biopsy in detecting prostate cancer using cumulative sum analysis. Curr. Urol. Pub Date : 2022-08-22 Linhan Xu,Nancy Yating Ye,Adrianna Lee,Jasleen Chopra,Michael Naslund,Jade Wong-You-Cheong,Amelia Wnorowski,Mohummad Minhaj Siddiqui
Background Targeted magnetic resonance (MR) with ultrasound (US) fusion-guided biopsy has been shown to improve detection of prostate cancer. The implementation of this approach requires integration of skills from radiologists and urologists. Objective methods for assessment of learning curves, such as cumulative sum (CUSUM) analysis, may be helpful in identifying the presence and duration of a learning
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Isolated ventral congenital penile curvature treated by incisionless plication of tunica albuginea in adults: A prospective case series. Curr. Urol. Pub Date : 2022-08-22 Rabea A Gadelkareem,Mohammed A Elgendy,Adel Kurkar,Ahmed M El-Taher,Islam F Abdelkawi
Background Numerous surgical techniques are available for the correction of isolated ventral congenital penile curvature (IVCPC). This study aimed to assess the outcomes and predictors of IVCPC treatment in adults using an incisionless plication technique. Materials and methods This prospective case series examined patients with IVCPC who were treated in our hospital between October 2017 and February
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Epidermoid cyst: An unusual presentation of a testicular mass. Curr. Urol. Pub Date : 2022-08-22 Andrew Stemberger,Marc Zeffren,Ruth Birbe,Wei Phin Tan
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Differences in rates of pelvic lymph node dissection in National Comprehensive Cancer Network favorable, unfavorable intermediate- and high-risk prostate cancer across United States SEER registries. Curr. Urol. Pub Date : 2022-08-22 Rocco Simone Flammia,Benedikt Hoeh,Francesco Chierigo,Lukas Hohenhorst,Gabriele Sorce,Zhen Tian,Costantino Leonardo,Markus Graefen,Carlo Terrone,Fred Saad,Shahrokh F Shariat,Alberto Briganti,Francesco Montorsi,Felix K H Chun,Michele Gallucci,Pierre I Karakiewicz
Background The National Comprehensive Cancer Network (NCCN) guidelines recommend pelvic lymph node dissection (PLND) in NCCN high- and intermediate-risk prostate cancer patients. We tested for PLND nonadherence (no-PLND) rates within the Surveillance Epidemiology and End Results (2010-2015). Materials and methods We identified all radical prostatectomy patients who fulfilled the NCCN PLND guideline
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