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The role of antimicrobial prophylaxis in laparoscopic nephrectomy for renal cell carcinoma BMC Urol. (IF 2.0) Pub Date : 2024-03-13 Mengchao Wei, Wenjie Yang, Weifeng Xu, Guanghua Liu, Yi Xie, Jie Dong, Zhigang Ji
To investigate the role of antimicrobial prophylaxis in laparoscopic nephrectomy for renal cell carcinoma. We retrospectively enrolled 1000 patients who underwent laparoscopic nephrectomy from August 2019 to November 2021 in the Peking Union Medical College Hospital. Patients were divided into group without antimicrobial prophylaxis (n = 444) and group with antimicrobial prophylaxis (n = 556). Outcomes
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The mechanism of PFK-1 in the occurrence and development of bladder cancer by regulating ZEB1 lactylation BMC Urol. (IF 2.0) Pub Date : 2024-03-13 Rong Wang, Fei Xu, Zhengjia Yang, Jian Cao, Liqi Hu, Yangyang She
Bladder cancer (BC) is one of the most common malignancies of the genitourinary system. Phosphofructokinase 1 (PFK-1) is one of member of PFK, which plays an important role in reprogramming cancer metabolism, such as lactylation modification. Zinc finger E-box-binding homeobox 1 (ZEB1) has been demonstrated to be a oncogene in many cancers. Therefore, this study was performed to explore the effects
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A contemporary comparison of laparoscopic versus open partial nephrectomy for renal cell carcinoma BMC Urol. (IF 2.0) Pub Date : 2024-03-12 Edouard Nicaise, Adam S. Feldman, Andrew Gusev, Alice Yu, Naren Nimmagadda, Matthew F. Wszolek, Francis McGovern, Michael L. Blute, Douglas M. Dahl
To analyze surgical and oncologic outcomes of patients undergoing open partial nephrectomy (OPN) versus laparoscopic partial nephrectomy (LPN) for treatment of renal cell carcinoma (RCC). We retrospectively investigated our institutional RCC database for patients who underwent PN for RCC from 1997 to 2018. Decision for technique was at the discretion of the operating urologist, following practice patterns
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Survival and clinicopathological significance of B7-H3 in bladder cancer: a systematic review and meta-analysis BMC Urol. (IF 2.0) Pub Date : 2024-03-11 Haohao sun, Fei Gao, Yuan Liu, Jianfeng Shao
B7-H3 has been implicated in clinical pathological features and prognosis across various cancer types, suggesting its potential as a cancer biomarker. Nevertheless, consensus remains elusive regarding its clinical-pathological and prognostic significance in bladder cancer. To address this gap, we conducted a systematic review and meta-analysis. We systematically searched PubMed, Embase, Web of Science
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Efficacy and safety of low-dose corticosteroids combined with leflunomide for progressive IgA nephropathy: a systematic review and meta-analysis BMC Urol. (IF 2.0) Pub Date : 2024-03-11 Dongxu Zhang, Bowen Xia, Xin Zhang, Pu Liang, Xiaopeng Hu
The effectiveness of immunosuppressive and corticosteroid treatments for Immunoglobulin A (IgA) nephropathy (IgAN) remains thoroughly evaluated. We undertook a meta-analysis to investigate the efficacy and safety of low-dose corticosteroids plus leflunomide for progressive IgA nephropathy. Eligible studies were obtained from PubMed, Embase, and Cochrane Library databases. We also searched the references
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A network meta-analysis evaluating the efficacy and safety of adjuvant therapy after nephrectomy in renal cell carcinoma BMC Urol. (IF 2.0) Pub Date : 2024-03-07 Lingyu Guo, Tian An, Zhixin Huang, Tie Chong
In the past few years, there has been a continuous rise in the occurrence of renal cell carcinoma (RCC), with RCC recurrence becoming the primary factor behind fatalities. Despite numerous clinical trials, the impact of different medications on the long-term survival of patients with RCC after surgery remains uncertain. This network meta-analysis aimed to evaluate the impact of various medications
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Comparison of lithotripsy methods during mini-PNL: is there a role for ballistic lithotripsy in the era of high-power lasers BMC Urol. (IF 2.0) Pub Date : 2024-03-07 Muhammed Arif Ibis, Ahmet Furkan Özsoy, Mehmet Fatih Özkaya, Emre Erdem, Serhat Erkmen, Ahmet Doruk Güler, Mehmet İlker Gökce
For renal stones > 20 mm, percutaneous nephrolithotomy (PNL) offers the best stone clearance rates with acceptable complication rates. This study aimed to compare the efficiency of high-power holmium YAG laser and ballistic lithotripsy during mini-PNL. Data from 880 patients who underwent mini-PNL for renal stones was investigated retrospectively. The study utilized propensity score matching to create
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Workflow efficiencies for flexible cystoscopy: comparing single-use vs reusable cystoscopes BMC Urol. (IF 2.0) Pub Date : 2024-03-06 Ian Haislip, Dinah Rindorf, Christina Cool, Brittany Tester
Flexible cystoscopy is a common procedure to diagnose and treat lower urinary tract conditions. Single-use cystoscopes have been introduced to eliminate time-consuming reprocessing and costly repairs. We compared the hands-on labor time differences between flexible reusable cystoscopes versus Ambu’s aScope™ 4 Cysto (aS4C) at a large urology Ambulatory Surgery Center (ASC). Reusable and single-use cystoscopy
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Forgotten ureteral stents: a systematic review of literature BMC Urol. (IF 2.0) Pub Date : 2024-03-05 Xiaochuan Wang, Zhengguo Ji, Peiqian Yang, Jun Li, Ye Tian
The forgotten ureteral stents (FUS) is one of the late complications of stent placement. This systematic review summarized different aspects of FUS and focused on the problems and solutions related to FUS. This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. PubMed® and Embase® were searched from inception
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Mast cell distribution and prevalence in the murine urinary bladder BMC Urol. (IF 2.0) Pub Date : 2024-03-05 Jessica Smith, Jonathan Kah Huat Tan, Christian Moro
Mast cells have been implicated in the pathology of various urinary bladder disorders. However, the distribution of mast cells throughout urinary bladder tissue remains uncertain despite mast cell prevalence being relatively well-defined. Using a mouse tissue model, this study aims to characterise the prevalence and distribution of mast cells throughout the urinary bladder. Bladder tissues were collected
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Utility of opportunistic screening to assess the impact of urinary incontinence on quality of life and barriers to seeking treatment among women attending a tertiary healthcare centre in North India BMC Urol. (IF 2.0) Pub Date : 2024-03-02 Priyanka Garg, Lajya Devi Goyal, Suresh Goyal, Madhur Verma
Urinary incontinence (UI) is a common but frequently neglected problem in females, significantly impacting their psychosocial health. The available estimates are an underestimation of a bigger problem. Thus, the study aimed to estimate the prevalence of UI, its associated risk factors, its impact on the Quality of life (QoL), and barriers to treatment-seeking behaviour in women attending tertiary healthcare
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Coping strategies mediate the relationship between fear of cancer recurrence and quality of life in postoperative patients with prostate cancer: a multicentre survey BMC Urol. (IF 2.0) Pub Date : 2024-03-01 Chen Yu, Zhu Jingzhen, Zhou Luqiang, Yuan Xiaojuan, Zheng Ji
The aim of the present study was to investigate the relationships between fear of cancer recurrence and quality of life in patients with prostate cancer. A model based on Lazarus’ and Folkman’s theory tested the specific hypothesis: fear of cancer recurrence has a direct and indirect effect on quality of life mediated by coping strategies. A questionnaire survey was conducted on 305 patients with prostate
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Impact of a Mediterranean diet on prevention and management of urologic diseases BMC Urol. (IF 2.0) Pub Date : 2024-02-26 Mark I Sultan, Shady A Ibrahim, Ramy F Youssef
Compared to a Western diet, the Mediterranean diet moves away from red meat and processed foods. Universally regarded as a healthier dietary alternative, the Mediterranean diet has garnered scientific endorsement for its ability to confer an array of compelling benefits. These health benefits encompass not only a lowered incidence of Type 2 diabetes with a reduction in obesity, but also a robust protective
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The association between hepatitis B virus and semen quality: a systematic review and meta-analysis BMC Urol. (IF 2.0) Pub Date : 2024-02-22 Yuting Xu, Kai Gan, Liqing Hou, Huawei Wang, June Cai, Liu Liu, Wen Wen, Meng Rao, Li Tang
Some studies have suggested that hepatitis B virus (HBV) infection had a negative association with semen quality, but the conclusions have been inconsistent. The purpose of our study was to systematically assess the association between HBV infection and semen parameters. We searched electronic databases for studies published from January 1980 to August 2023. Eleven studies were included in the analysis
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Distribution and antimicrobial resistance patterns of urinary pathogens in preoperative midstream urine cultures from Chinese patients with urinary calculi: a meta-analysis BMC Urol. (IF 2.0) Pub Date : 2024-02-21 Xin Mei, Shike Zhang, Peng Xu, Zhican He, Ruizheng Tang, Baotong Yang, Iqbal Muhammad Sarfaraz, Wenqi Wu
This study comprehensively evaluates the distribution patterns and antimicrobial resistance profiles of urinary pathogens in Preoperative midstream urine cultures collected from patients with urinary calculi in China over the last two decades. A cross-sectional analysis of 41 studies was conducted. A systematic search across various databases, including Wanfang Data, CNKI, SinoMed, Embase, PubMed,
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Cost-effectiveness and budget impact analysis of enzalutamide in comparison to abiraterone in treatment of metastatic prostate cancer resistant to castration in Iran BMC Urol. (IF 2.0) Pub Date : 2024-02-20 Zahra Goudarzi, Farhad Lotfi, Zhila Najafpour, AliAkbar Hafezi, Marzieh Alizadeh Zakaria, Khosro Keshavarz
In recent years, enzalutamide and abiraterone have been widely used as treatments for metastatic castration-resistant prostate cancer (mCRPC). However, the cost-effectiveness of these drugs in Iran is unknown. This study evaluated the cost-effectiveness of enzalutamide for the treatment of metastatic prostate cancer resistant to castration in Iran. A 3-state Markov model was developed to evaluate the
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Comparison of Thulium Fiber Laser versus Holmium laser in ureteroscopic lithotripsy: a Meta-analysis and systematic review BMC Urol. (IF 2.0) Pub Date : 2024-02-19 Xiaoyu Tang, Shaojie Wu, Zhilong Li, Du Wang, Cheng Lei, Tongzu Liu, Xinghuan Wang, Sheng Li
To compare the efficacy and safety of thulium fiber laser (TFL) to holmium: YAG (Ho: YAG) laser in ureteroscopic lithotripsy for urolithiasis. PubMed, Web of Science, Embase, CENTRAL, SinoMed, CNKI database, VIP and Wanfang Database were systematically searched for all relevant clinical trials until September 2023. References were explored to identify the relevant articles. Meta-analysis was carried
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Giant peritoneal loose body and its protein composition: a case report BMC Urol. (IF 2.0) Pub Date : 2024-02-17 Weicong Sang, Yang Li, Xiaoping Hong, Haihong Qu, Rujian Zhu, Qingtong Yi
Peritoneal loose body (PLB) is a kind of lesions located in the abdominal cavity or pelvic cavity, which is rare and difficult to diagnose. The diameter of PLB is mostly 0.5–2.5 cm. Most PLBS are asymptomatic. Here we reported a case of giant PLB in the pelvis and analyzed its structure and protein composition. Surgical exploration revealed a white oval mass (4.5*4*3 cm) in the pelvic cavity. After
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Risk factors for postpartum stress urinary incontinence: a prospective study BMC Urol. (IF 2.0) Pub Date : 2024-02-16 Wei Liu, Linxue Qian
Postpartum stress urinary incontinence (SUI) is a common occurrence in women, and it has a profound effect on women’s health and quality of life. This study aimed to investigate the risk factors for postpartum SUI and the relative importance of each factor, including pelvic floor ultrasound measurement data and clinical data. Pregnant women who delivered in our hospital from March 2021 to January 2022
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De Garengeot Hernia, an acute appendicitis in the right femoral hernia canal, and successful management with transabdominal closure and appendectomy: a case Report BMC Urol. (IF 2.0) Pub Date : 2024-02-16 Po-Chuan Yu, Ling-Ting Wang, Chun-Yu Chang, Yao-Chou Tsai, Kian-Hwee Chong
Incarceration of the appendix within a femoral hernia is a rare condition of abdominal wall hernia about 0.1 to 0.5% in reported femoral hernia [1]. We report a case of a 56-year-old female whose appendix was trapped in the right femoral canal. There are few reports in the literature on entrapment of the appendix within a femoral hernia. The management of this condition includes antibiotics, drainage
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Values of multiparametric and biparametric MRI in diagnosing clinically significant prostate cancer: a multivariate analysis BMC Urol. (IF 2.0) Pub Date : 2024-02-16 Xiao Feng, Xin Chen, Peng Peng, He Zhou, Yi Hong, Chunxia Zhu, Libing Lu, Siyu Xie, Sijun Zhang, Liling Long
To investigate the value of semi-quantitative and quantitative parameters (PI-RADS score, T2WI score, ADC, Ktrans, and Kep) based on multiparametric MRI (mpMRI) or biparametric MRI (bpMRI) combined with prostate specific antigen density (PSAD) in detecting clinically significant prostate cancer (csPCa). A total of 561 patients (276 with csPCa; 285 with non-csPCa) with biopsy-confirmed prostate diseases
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A retrospective comparison of Sun’s tip-flexible semirigid ureterorenoscopy, super-mini percutaneous nephrolithotomy and flexible ureteroscopy applied to treat upper urinary tract calculi BMC Urol. (IF 2.0) Pub Date : 2024-02-14 Xinkai Huang, Liang Zhong, Zhifeng Huang, Haibiao Lai
This retrospective study was conducted to compare the safety and efficacy of Sun’s tip-flexible semirigid ureterorenoscopy (tf-URS), super-mini percutaneous nephrolithotomy (SMP) and flexible ureteroscopy (FURS) in treating upper urinary tract calculi, including upper ureteral or renal calculi. We included patients with upper ureteral calculi or renal calculi 1.0–2.0 cm in size, who underwent tf-URS
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Correlation between metabolic syndrome and periurethral prostatic fibrosis: results of a prospective study BMC Urol. (IF 2.0) Pub Date : 2024-02-12 Jingwen Ren, Yuanyuan Li, Xueyuan Zhang, Min Xiong, Heng Zhang, Lingyue An, Ying Cao, Shujie Xia, Guangheng Luo, Ye Tian
Prostatic fibrosis, characterized by the accumulation of myofibroblasts and collagen deposition, is closely associated with LUTS and may lead to mechanical obstruction of the urethra. Additionally, Metabolic Syndrome (MetS), characterized by central obesity, high blood sugar, lipid metabolism disorders, and hypertension, is increasingly recognized as a proinflammatory condition linked to prostate inflammation
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Arabic version of the SF-Qualiveen: cross-cultural adaptation, translation, and validation of urinary disorder‐specific instruments in patients with multiple sclerosis BMC Urol. (IF 2.0) Pub Date : 2024-02-12 Younes A. Khadour, Meng Zheng, Fater A. Khadour
The Short Form Qualiveen (SF-Qualiveen) questionnaire assesses the effect of bladder and urinary symptoms on patients’ quality of life (QoL) with urological impairment caused by neurological diseases. There is no validated SF-Qualiveen questionnaire in Arabic, so this study aims to provide a translated and validated version of the SF-Qualiveen questionnaire among Arabic-speaking patients with multiple
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46, XX disorder of sexual development associated with mixed germ cell tumor of the prostate: a rare case report BMC Urol. (IF 2.0) Pub Date : 2024-02-12 Changrong Wang, Jiangli Du, Xueping Xiang, Yuyong Wang, Jingjing Xiang, Qiaoping Xu
Extragonadal germ cell tumors originating from the prostate are exceptionally rare. To the best of our knowledge, there have been no reported cases of mixed germ cell tumors in individuals with 46 XX disorder of sex development. In this study, we conducted a comprehensive analysis using whole genome sequencing to investigate the clinicopathological and molecular genetic characteristics of a submitted
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Prostate cancer presentation and management in the Middle East BMC Urol. (IF 2.0) Pub Date : 2024-02-09 Mutlay Sayan, Astrid Langoe, Ozlem Aynaci, Ayfer Ay Eren, Mehmet Fuat Eren, Ilke Onur Kazaz, Zainab Ibrahim, Omar Tama Al-Akelie, Loma Al-Mansouri, Ramiz Abu-Hijlih, Shalini Moningi, Elia Abou Chawareb, Albert El Hajj, Peter F. Orio, Layth Mula-Hussain
Although prostate cancer is a prevalent malignancy worldwide, its clinical presentation and management in the Middle East are not well-documented. This study aims to provide insights into the initial clinical presentation and management of prostate cancer in this region. A retrospective review was conducted on seven institutional databases from six Middle Eastern countries, including Türkiye, Lebanon
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The role of URO17® in diagnosis and follow up of bladder cancer patients BMC Urol. (IF 2.0) Pub Date : 2024-02-09 Mohamed Ibrahim, Joshua Rabinowitz, Rebecca Hilbert, Aruni Ghose, Samita Agarwal, Rajiv Swamy, Ismail Bulut, Mirian Guttierrez, Ebtisam Buali, Ekram Nassar, Parag Jhavar, Fatima Al-Hashimi, Nikhil Vasdev
to evaluate the role of urinary URO17® biomarker in the detection of urothelial tumors in haematuria patients and the detection of recurrence in non-muscle invasive bladder urothelial tumors. Our study was formed of two cohorts of patients, group I represents patients presenting with haematuria (n = 98), while group II represents patients with known non-muscle invasive bladder cancers on their scheduled
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De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors BMC Urol. (IF 2.0) Pub Date : 2024-02-07 Akshay Akshay, Ali Hashemi Gheinani, Mustafa Besic, Sophie Braga, Anne-Christine Uldry, Manfred Heller, Hubert Rehrauer, Catharine Aquino Fournier, Fiona C. Burkhard, Katia Monastyrskaya
Benign prostatic hyperplasia in elderly males often causes bladder outlet obstruction termed benign prostatic obstruction (BPO). BPO induces lower urinary tract symptoms and quantifiable urodynamic alterations in bladder function. When conservative medical treatments are exhausted, surgical interventions like transurethral resection of the prostate (TURP) are employed for bladder outlet de-obstruction
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USP54 is a potential therapeutic target in castration-resistant prostate cancer BMC Urol. (IF 2.0) Pub Date : 2024-02-06 Cheng Zhou, Xuehu Zhang, Hangbin Ma, Yinghao Zhou, Yibo Meng, Chenchen Chen, Guowei Shi, Wandong Yu, Jun Zhang
USP54, a ubiquitin-specific protease in the deubiquitinase (DUB) family, facilitates the malignant progression of several types of cancer. However, the role of USP54 in prostate cancer (PCa), especially castration-resistant prostate cancer (CRPC), remains unknown. We established the CRPC LNCaP-AI cell line from the hormone-sensitive prostate cancer (HSPC) LNCaP cell line. RNA-Seq was utilized to explore
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Neoadjuvant stereotactic ablative body radiotherapy combined with surgical treatment for renal cell carcinoma and inferior vena cava tumor thrombus: a prospective pilot study BMC Urol. (IF 2.0) Pub Date : 2024-02-03 Jiyuan Chen, Zhuo Liu, Ran Peng, Yunchong Liu, Hongxian Zhang, Guoliang Wang, Xiaojun Tian, Xinlong Pei, Junjie Wang, Shudong Zhang, Hao Wang, Lulin Ma
Surgical treatment for renal cell carcinoma (RCC) and inferior vena cava (IVC) tumor thrombus (TT) is difficult, and the postoperative complication rate is high. This study aimed to explore the safety and oncologic outcomes of neoadjuvant stereotactic ablative body radiotherapy (SABR) combined with surgical treatment for RCC and IVC-TT. Patients with RCC and IVC-TTs were enrolled in this study. All
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Seminal papers in urology: urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study BMC Urol. (IF 2.0) Pub Date : 2024-02-03 Adam Collingridge, Michael O’Callaghan
Kidney stones, a persistent urological condition, continue to affect people globally. In this critical review, we examine the work of Borghi et al. who evaluated patients with idiopathic stone formation and randomised 99 patients to increased water intake (≥ 2 L/day) and 100 patients to usual care in a 5-year randomized controlled trial. The study examined baseline urine volume in individuals with
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Transperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial BMC Urol. (IF 2.0) Pub Date : 2024-02-03 Junyao Liu, Bin Zhang, Peng Qi, Xiaowei Ren, Duo Zheng, Yang He, Xu Zheng, Zhongjin Yue, Ye Li, Ningqiang Yang, Zhiping Wang, Junsheng Bao, Junqiang Tian, Li Yang, Zhenxing Zhai, Lingjun Zuo, Zizhen Hou, Jiaji Wang, Wei Wang, Hong Chang, Junhai Ma, Yunxin Zhang, Zhichun Dong, Zhilong Dong, Ganping Zhong, Hui Cheng, Pengyuan Lei, Zhongming Li, GongJin Wu, Panfeng Shang
To compare the outcomes of patients undergoing Retroperitoneal laparoscopic Radical nephrectomy (RLRN) and Transperitoneal laparoscopic Radical nephrectomy (TLRN). A total of 120 patients with localized renal cell carcinoma were randomized into either RLRN or TLRN group. Mainly by comparing the patient perioperative related data, surgical specimen integrity, pathological results and tumor results.
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Converting between the International Prostate Symptom Score (IPSS) and the Expanded Prostate Cancer Index Composite (EPIC) urinary subscales: modeling and external validation BMC Urol. (IF 2.0) Pub Date : 2024-02-03 Paul Windisch, Ivo Becker, Hongjian Tang, Christina Schröder, André Buchali, Daniel M. Aebersold, Daniel R. Zwahlen, Robert Förster, Mohamed Shelan
Prostate-related quality of life can be assessed with a variety of different questionnaires. The 50-item Expanded Prostate Cancer Index Composite (EPIC) and the International Prostate Symptom Score (IPSS) are two widely used options. The goal of this study was, therefore, to develop and validate a model that is able to convert between the EPIC and the IPSS to enable comparisons across different studies
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A novel post-percutaneous nephrolithotomy sepsis prediction model using machine learning BMC Urol. (IF 2.0) Pub Date : 2024-02-02 Rong Shen, Shaoxiong Ming, Wei Qian, Shuwei Zhang, Yonghan Peng, Xiaofeng Gao
To establish a predictive model for sepsis after percutaneous nephrolithotomy (PCNL) using machine learning to identify high-risk patients and enable early diagnosis and intervention by urologists. A retrospective study including 694 patients who underwent PCNL was performed. A predictive model for sepsis using machine learning was constructed based on 22 preoperative and intraoperative parameters
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Establishment and validation of a novel peroxisome-related gene prognostic risk model in kidney clear cell carcinoma BMC Urol. (IF 2.0) Pub Date : 2024-01-31 Jing Zhang, Qian Zhao, Hongwei Huang, Xuhong Lin
Kidney clear cell carcinoma (KIRC) is the most common subtype of renal cell carcinoma. Peroxisomes play a role in the regulation of tumorigenesis and cancer progression, yet the prognostic significance of peroxisome-related genes (PRGs) remains rarely studied. The study aimed to establish a novel prognostic risk model and identify potential biomarkers in KIRC. The significant prognostic PRGs were screened
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Is switching intravesical chemotherapeutic agents beneficial in short-term recurrent high-risk non-muscle-invasive bladder tumors? A 5-year retrospective study BMC Urol. (IF 2.0) Pub Date : 2024-01-31 Shuaiqi Chen, Guangyu Sun, Xiaoxu Chen, Tiyara Salgado, Shangrong Wu, Hailong Hu, Ranlu Liu, Yunkai Qie
To explore if switching intravesical chemotherapeutic agents is beneficial in short-term recurrences of high-risk non-muscle-invasive bladder cancer (NMIBC) following the failure of preceding intravesical therapy. From June 2010 to October 2015, 205 patients with NMIBC who experienced tumor recurrence within a year after receiving first-line intravesical chemotherapy (IVC) were classified into two
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Outcomes of robot-assisted laparoscopic extended pelvic lymph node dissection for prostate Cancer BMC Urol. (IF 2.0) Pub Date : 2024-01-29 Silvan Sigg, Fabienne Lehner, Etienne Xavier Keller, Karim Saba, Holger Moch, Tullio Sulser, Daniel Eberli, Ashkan Mortezavi
Extended pelvic lymph node dissection (ePLND) in men undergoing robot-assisted laparoscopic radical prostatectomy (RARP) is a widely used procedure. However, little is known about anatomical site-specific yields and subsequent metastatic patterns in these patients. Data on a consecutive series of 1107 patients undergoing RARP at our centre between 2004 and 2018 were analysed. In men undergoing LN dissection
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Comparison of percutaneous nephrolithotomy and flexible ureterorenoscopy in the treatment of single upper ureteral calculi measuring 1 to 2 centimeters: a retrospective study BMC Urol. (IF 2.0) Pub Date : 2024-01-28 Qinghua He, Xuedong Wei, Eran Wu, Raoshan Luo, Lizhi Yu, Weiming Liang
To compare the efficacy and safety of micropercutaneous nephrolithotomy (MPCNL) and flexible ureteroscopy (FURS) in the treatment of single upper ureteral calculi measuring 1 to 2 centimeters. This study is a retrospective analysis that combines a review of medical records with an outcomes management database. A total of 163 patients who underwent MPCNL and 137 patients who had FURS were identified
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Comparing prostatic artery embolization to surgical and minimally invasive procedures for the treatment of benign prostatic hyperplasia: a systematic review and meta-analysis BMC Urol. (IF 2.0) Pub Date : 2024-01-28 Rachel Altman, Roseanne Ferreira, Camilo Barragan, Naeem Bhojani, Katherine Lajkosz, Kevin C. Zorn, Bilal Chughtai, Ganesan Annamalai, Dean S. Elterman
To summarize current evidence to report a comparative systematic review and meta-analysis of prostatic artery embolization (PAE) with transurethral resection of the prostate (TURP) and open simple prostatectomy (OSP) for the treatment of benign prostatic hyperplasia (BPH). A systematic literature search was performed to identify studies published from inception until August 2021. The search terms used
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Hypertension and urologic chronic pelvic pain syndrome: An analysis of MAPP-I data BMC Urol. (IF 2.0) Pub Date : 2024-01-28 Rosalynn R.Z. Conic, Terrie Vasilopoulos, Karthik Devulapally, Rene Przkora, Andrew Dubin, Kimberly T. Sibille, Aaron D. Mickle
Urologic chronic pelvic pain syndrome (UCPPS), which includes interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis (CP/CPPS), is associated with increased voiding frequency, nocturia, and chronic pelvic pain. The cause of these diseases is unknown and likely involves many different mechanisms. Dysregulated renin-angiotensin-aldosterone-system (RAAS) signaling is a potential
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Evaluating noninvasive brain stimulation to treat overactive bladder in individuals with multiple sclerosis: a randomized controlled trial protocol BMC Urol. (IF 2.0) Pub Date : 2024-01-25 Betsy H. Salazar, Kristopher A. Hoffman, John A. Lincoln, Christof Karmonik, Hamida Rajab, Santosh A. Helekar, Rose Khavari
Multiple Sclerosis (MS) is an often debilitating disease affecting the myelin sheath that encompasses neurons. It can be accompanied by a myriad of pathologies and adverse effects such as neurogenic lower urinary tract dysfunction (NLUTD). Current treatment modalities for resolving NLUTD focus mainly on alleviating symptoms while the source of the discomfort emanates from a disruption in brain to bladder
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Perioperative, functional, and oncological outcomes after cryoablation or partial nephrectomy for small renal masses in solitary kidneys: a systematic review and meta-analysis BMC Urol. (IF 2.0) Pub Date : 2024-01-24 Ying Liu, Li Wang, Er-hao Bao, Lei Wang, Jia-hao Wang, Lin Yang, Ping-yu Zhu
This study aims to compare the perioperative, functional, and oncological outcomes of cryoablation (CA) and partial nephrectomy (PN) for managing small renal masses in patients with solitary kidneys. The study seeks to assess the efficacy and safety of both interventions, evaluating their impact on kidney function and their ability to mitigate cancer recurrence. Searches were systematically conducted
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Association of estimated glomerular filtration rate with prostate cancer risk in a cross-ethnic population: a Mendelian randomization study BMC Urol. (IF 2.0) Pub Date : 2024-01-23 Haojian Zhang, Tian Li, Yingjie Jia
To investigate whether a causal relationship exists between the estimated glomerular filtration rate (EGFR) and the occurrence of prostate cancer in East Asian and European populations and to determine if genetic factors influence the association between the EGFR and prostate cancer risk. In this Mendelian randomization study, the existence of a causal relationship between the EGFR and prostate cancer
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Percutaneous nephrolithotomy guided by 5G-powered robot-assisted teleultrasound diagnosis system: first clinical experience with a novel tele-assistance approach (IDEAL stage 1) BMC Urol. (IF 2.0) Pub Date : 2024-01-18 Jie Yang, Xiang Zhou, Xuan Zhou, Jin-yong Tian, Muhetaer Wubuli, Xin-hua Ye, Jie Li, Ning-hong Song
To demonstrate the technical feasibility of percutaneous nephrolithotomy (PCNL) guided by 5G-powered robot-assisted teleultrasound diagnosis system (RTDS) in a complex kidney-stone (CKS) cohort and present our preliminary outcomes. PCNL is highly skill-required, which hinders it popularization in primary medical units of remote regions. We designed an innovative tele-assistance approach to make PCNL
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Seminal papers in urology: two-year outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for refractory urgency urinary incontinence: a Randomized Trial BMC Urol. (IF 2.0) Pub Date : 2024-01-16 Haidar Hadri bin Abd Wahab, Michael O’Callaghan
In this critical review, we explore the study design, strengths and limitations of the paper: “Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial.” The paper reports 24 month follow-up data of the landmark ROSETTA trial. This multi-centre, open-labelled parallel randomised trial allocated females 1:1 to receive Sacral
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Correction: MicroRNA-148a-3p in pericyte-derived extracellular vesicles improves erectile function in diabetic mice by promoting cavernous neurovascular regeneration BMC Urol. (IF 2.0) Pub Date : 2024-01-13 Jiyeon Ock, Fang-Yuan Liu, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Shuguang Piao, Tie Zhou, Yin Guonan
BMC Urology (2023) 23:209 https://doi.org/10.1186/s12894-023-01378-4 The author name “Yin Guonan” was incorrectly written as “Yin Gounan” and the same has been updated. The original article has been corrected. Authors and Affiliations Department of Urology and National Research Center for Sexual Medicine, Inha University School of Medicine, 7-206, 3rd ST, Shinheung-Dong, Jung-Gu, Incheon, 22332, Republic
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Predictive value of SIRI and SII for metastases in RCC: a prospective clinical study BMC Urol. (IF 2.0) Pub Date : 2024-01-13 Emre Arı, Hikmet Köseoğlu, Tolga Eroğlu
In this prospective cross-sectional clinical study, we aimed to determine the efficiency of preoperative hematological markers namely SIRI (systemic inflammatory response index) and SII (systemic inflammatory index) for renal cell cancer to predict the possibility of postoperative metastases. Istanbul Education and Research Hospital, Clinic of Urology and Medical Oncology in the clinic between the
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Anemia in patients ≥ 75 years with metastatic clear cell renal cell carcinoma: an important poor prognostic factor in the international metastatic renal cell carcinoma database consortium model BMC Urol. (IF 2.0) Pub Date : 2024-01-11 Ryuichi Mizuno, Yota Yasumizu, Nobuyuki Tanaka, Toshikazu Takeda, Shinya Morita, Kazuhiro Matsumoto, Takeo Kosaka, Hiroshi Asanuma, Mototsugu Oya
Due to an increase in life expectancy, the incidence of metastatic renal cell carcinoma (mRCC) in patients aged ≥75 years has been increasing. In this study we investigated the characteristics before treatment and the outcomes of systemic therapies for patients aged ≥75 years with mRCC and compared the results with those for patients aged < 75 years in order to determine whether differences in age
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Prognostic significance of surgery and radiotherapy in elderly patients with localized prostate cancer: establishing and time-based external validation a nomogram from SEER-based study BMC Urol. (IF 2.0) Pub Date : 2024-01-06 Chenghao Zhanghuang, Jianjun Zhu, Ye Li, Jinkui Wang, Jing Ma, Li Li, Zhigang Yao, Fengming Ji, Chengchuang Wu, Haoyu Tang, Yucheng Xie, Bing Yan, Zhen Yang
Prostate cancer (PC) is a significant disease affecting men’s health worldwide. More than 60% of patients over 65 years old and more than 80% are diagnosed with localized PC. The current choice of treatment modalities for localized PC and whether overtreatment is controversial. Therefore, we wanted to construct a nomogram to predict the risk factors associated with cancer-specific survival (CSS) and
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Incidence of renal cell carcinoma after solid organ transplantation: a systematic review and meta-analysis BMC Urol. (IF 2.0) Pub Date : 2024-01-06 Chang Xu, Hefeng Geng, Yannan Li, Fang Sun, Huiwei Sun, Yingshi Zhang, Qingchun Zhao
The incidence rate of malignant tumors after solid organ transplantation is higher than the normal population. The aim of our study is to identify the risk of renal cell carcinoma (RCC) after liver, kidney, heart and lung transplantation, respectively, and suggest that transplant patients can be screened early for tumors to avoid risk. PubMed, Embase and the Cochrane Library from their inception until
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Heteronormative biases and distinctive experiences with prostate cancer among men who have sex with men: a qualitative focus group study BMC Urol. (IF 2.0) Pub Date : 2024-01-06 Evan Panken, Noah Frydenlund, Neil Mistry, Rahul Prabhu, Jeffrey Wong, Shilajit Kundu, David Victorson, Channa Amarasekera
Men who have sex with men (MSM) face many challenges and biases in healthcare. Within urology there is a need to better understand how prostate cancer impacts MSM given the unique ways in which side effects that accompany treatment may affect this population. The goal of this study is to explore the experience of MSM with prostate cancer to advance the existing literature in this area and inform implementation
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Sagittal septum duplication of bladder and duplication of posterior urethra combined with congenital megacolon: a case report and literature review BMC Urol. (IF 2.0) Pub Date : 2024-01-03 Shuying Luo, Junwei Liu, Peng Su, Hong Yu, Bangguo Li
Duplication of the bladder with duplication of the posterior urethra is a relatively rare congenital malformation. Cases of sagittal septum duplication of the bladder with duplication of the posterior urethra have rarely been reported. Furthermore, the combination thereof with congenital megacolon is rare. A 21-year-old male was admitted to our hospital because of frequent urination for two months
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RUNX3 pathway signature predicts clinical benefits of immune checkpoint inhibition plus tyrosine kinase inhibition in advanced renal cell carcinoma BMC Urol. (IF 2.0) Pub Date : 2024-01-03 Jiajun Wang, Sihong Zhang, Ying Wang, Yanjun Zhu, Xianglai Xu, Jianming Guo
Checkpoint inhibitor immunotherapy plus tyrosine kinase inhibitor (IO/TKI) have been recently recommended as standard first-line therapy for advanced renal cell carcinoma, while no clinical-available biomarker has been applied. This study aimed to investigate the associations between RUNX3 pathway signature and IO/TKI benefits in renal cell carcinoma (RCC). Two IO/TKI cohorts (ZS-MRCC, JAVELIN-101)
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The prevalence of probable overactive bladder and associated risk factors among medical students in Jordan: a cross-sectional study BMC Urol. (IF 2.0) Pub Date : 2024-01-03 Saleh Abuorouq, Mohammad Al-Zubi, Abdullah M. Al-Ali, Laith H. Aloqaily, Malek A. Talafha, Azmi M. Migdadi, Hashem Abu Serhan
To discuss the impact of overactive bladder (OAB) on medical students. overactive bladder. is a chronic condition that causes sudden and intense urges to urinate, which can have significant physical and psychological effects on patients’ lives. The prevalence of OAB among medical students is relatively high, with some studies reporting rates as high as 35.4%. This research aims to shed light on the
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Identification of clinical prognostic factors and analysis of ferroptosis-related gene signatures in the bladder cancer immune microenvironment BMC Urol. (IF 2.0) Pub Date : 2024-01-03 Jiafu Ma, Jianting Hu, Leizuo Zhao, Zixuan Wu, Rongfen Li, Wentao Deng
Bladder cancer (BLCA) is a prevalent malignancy affecting the urinary system and poses a significant burden in terms of both incidence and mortality rates on a global scale. Among all BLCA cases, non-muscle invasive bladder cancer constitutes approximately 75% of the total. In recent years, the concept of ferroptosis, an iron-dependent form of regulated cell death marked by the accumulation of lipid
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Predicting stone composition via machine-learning models trained on intra-operative endoscopic digital images BMC Urol. (IF 2.0) Pub Date : 2024-01-03 Guanhua Zhu, Chengbai Li, Yinsheng Guo, Lu Sun, Tao Jin, Ziyue Wang, Shiqing Li, Feng Zhou
The aim of this study was to use deep learning (DL) of intraoperative images of urinary stones to predict the composition of urinary stones. In this way, the laser frequency and intensity can be adjusted in real time to reduce operation time and surgical trauma. A total of 490 patients who underwent holmium laser surgery during the two-year period from March 2021 to March 2023 and had stone analysis
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CT findings and clinical characteristics in distinguishing renal urothelial carcinoma mimicking renal cell carcinoma from clear cell renal cell carcinoma BMC Urol. (IF 2.0) Pub Date : 2024-01-03 Xin Chen, Xiao Feng, Yidi Chen, Fulin Huang, Liling Long
We aimed to characterize the clinical and multiphase computed tomography (CT) features, which can distinguish renal urothelial carcinoma (RUC) mimicking renal cell carcinoma (RCC) from clear cell renal cell carcinoma (ccRCC) with collecting system invasion (CSI). Data from 56 patients with RUC (46 men and 10 women) and 366 patients with ccRCC (262 men and 104 women) were collected and assessed retrospectively
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Type 2 diabetes mellitus increases the risk of circumcision among men aged between 30 and 69 years using a nationwide population-based dataset in Taiwan: a five-year follow-up study BMC Urol. (IF 2.0) Pub Date : 2024-01-03 Yun-Rui Wu, Yi-Horng Lai, Chung-Cheng Wang
Diabetes is an important factor in the development of penile inflammation. We studied whether type 2 diabetes (DM), with/without hypertension and hyperlipidemia increased the risk of circumcision among men aged between 30 and 69 using a population-based dataset in Taiwan during a 5-year follow-up period. The research data in this study were obtained from Taiwan’s National Health Insurance Research
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External validation of predictive models of sexual, urinary, bowel and hormonal function after surgery in prostate cancer subjects BMC Urol. (IF 2.0) Pub Date : 2024-01-02 Matthew A. Borg, Michael E. O’Callaghan, Kim L. Moretti, Andrew D. Vincent
In 2020, a research group published five linear longitudinal models, predict Expanded Prostate Cancer Index Composite-26 (EPIC-26) scores post-treatment for radical prostatectomy, external beam radiotherapy and active surveillance collectively in US patients with localized prostate cancer. Our study externally validates the five prediction models for patient reported outcomes post-surgery for localised
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Laparoscopic orchidopexy for the treatment of cryptorchidism in adults: a description of the technique and outcomes BMC Urol. (IF 2.0) Pub Date : 2024-01-02 Hu Han, Jiaxing Li, Hong-en Lei, Hang Yin, Long Tian
There are few studies on cryptorchidism in adults, and its treatment is still controversial. To summarize the surgical strategy and clinical efficacy of laparoscopic orchidopexy for the treatment of cryptorchidism in adults, 37 adult cryptorchidism patients were retrospectively analyzed between September 2017 and February 2022. All 37 patients underwent laparoscopic orchidopexy, of whom 33 underwent