当前期刊: Chest Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Subclavian Artery Branch Pseudoaneurysm Rupture With Massive Hemothorax in a Patient With Neurofibromatosis Type 1
    Chest (IF 9.657) Pub Date : 2020-04-03
    Katherine E. Negreira; John P. Lichtenberger; Blair Allais; Ammar Alhaddad; Matthew Bernetich; Vivek Jain

    Neurofibromatosis type 1 is a rare disorder that occurs secondary to pathogenic variants in the NF1 tumor suppressor gene on chromosome 17. Characteristic clinical manifestations include multiple hyperpigmented macules, axillary and inguinal freckling, optic gliomas, and numerous skin neurofibromas. Vasculopathies are a rare complication of this disease and can affect vessels ranging from the proximal

    更新日期:2020-04-03
  • Venoocclusive Disease With Both Hepatic and Pulmonary Involvement
    Chest (IF 9.657) Pub Date : 2020-04-03
    Noémie Tissot; David Montani; Marie-France Seronde; Bruno Degano; Thibaud Soumagne

    Pulmonary venoocclusive disease (PVOD) is a rare form of pulmonary vascular disease with pulmonary hypertension characterized by preferential involvement of the pulmonary venous system. Hepatic venoocclusive disease (HVOD), also known as sinusoidal obstruction syndrome, is a condition that occurs in 13% to 15% of patients after hematopoietic stem cell transplantation (HSCT). Although hepatic and pulmonary

    更新日期:2020-04-03
  • A 21-Year-Old Immune-Competent Man With Recurrent Cough
    Chest (IF 9.657) Pub Date : 2020-04-03
    Xiangning Yuan; Mao Jiang; Lijian Tao; Huanxing Sun; Jie Meng

    Case Presentation A 21-year-old Chinese man presented with a nonproductive cough for the past 5 months. He denied fevers, chills, night sweats, chest pain, dyspnea, hemoptysis, or weight loss. He was an undergraduate with an unremarkable medical history. He denied any sick contacts and he never smoked. Laboratory tests showed a leukocyte count of 11,200/μL (normal range, 3,500-9,500/μL) with a high

    更新日期:2020-04-03
  • A 51-Year-Old Man With Hoarseness of Voice
    Chest (IF 9.657) Pub Date : 2020-04-03
    Brittany Bass; Varun Shah; Anu Menon; Ann Tilley

    Case Presentation A 51-year-old nonsmoking man presented to his general practitioner with a primary complaint of 4 months of progressive hoarseness, and was subsequently referred to an otolaryngologist. He had no relevant medical or surgical history. He did not take any chronic medications or supplements. He was born in the Dominican Republic and moved to New York City when he was 36 years old. He

    更新日期:2020-04-03
  • A 55-Year-Old Man With Cough and Hematochezia
    Chest (IF 9.657) Pub Date : 2020-04-03
    Carmen Kut; Bruce F. Sabath

    Case Presentation A 55-year-old man presented to the ED with a 3-week history of worsening cough and shortness of breath. He had blood-tinged sputum, fever, night sweats, and a 2.7 kg weight loss within the same period. For the past few days, he had taken amoxicillin-clavulanate for presumed sinusitis. Despite this, his symptoms persisted, prompting him to seek further evaluation. His medical history

    更新日期:2020-04-03
  • A 36-Year-Old Woman Presenting With Left Upper Quadrant Discomfort, Encephalopathy, and Respiratory Failure
    Chest (IF 9.657) Pub Date : 2020-04-03
    Ryan Hyde; Julian Chung; Ibrahim Faruqi

    Case Presentation A 36-year-old woman with a history of hypertension and alcoholism reported 2 days of left upper quadrant pain and jaundice. Within hours of admission, she became somnolent and hypoxic. The patient was then intubated. She had no history of drug abuse, cigarette smoking, liver disease, autoimmune disease, or pancreatitis. She had no home medications.

    更新日期:2020-04-03
  • A 34-Year-Old Man With a Chylothorax and Bony Pain
    Chest (IF 9.657) Pub Date : 2020-04-03
    Marissa O’Callaghan; Aurelie Fabre; Jeff McCann; Gerard Healy; Aoife McCarthy; Michael P. Keane; Timothy J. McDonnell; Cormac McCarthy

    Case Presentation A 34-year-old man presented to a community hospital with sudden-onset pleuritic chest pain on a background of a 12-month indolent history of progressive exertional dyspnea. He denied cough, fevers, night sweats, or weight loss. He reported some low back pain and ache. He had a history of gastroesophageal reflux and was a current smoker with a 20-pack year history. There were no known

    更新日期:2020-04-03
  • Effect of intermittent or continuous feed on muscle wasting in critical illness: A phase II clinical trial
    Chest (IF 9.657) Pub Date : 2020-04-02
    Angela S. McNelly; Danielle E. Bear; Bronwen A. Connolly; Gill Arbane; Laura Allum; Azhar Tarbhai; Jackie A. Cooper; Philip A. Hopkins; Matthew P. Wise; David Brealey; Kieron Rooney; Jason Cupitt; Bryan Carr; Kiran Koelfat; Steven Olde Damink; Philip J. Atherton; Nicholas Hart; Hugh E. Montgomery; Zudin A. Puthucheary

    Background Acute skeletal muscle wasting in critical illness is associated with excess morbidity and mortality. Continuous feeding may suppress muscle protein synthesis as a result of the muscle-full effect, unlike intermittent feeding which may ameliorate it. Research Question Does intermittent enteral feed decrease muscle wasting compared with continuous feed in critically ill patients? Study Design

    更新日期:2020-04-03
  • Outcomes of a Peri and Post-operative management protocol for Nontuberculous mycobacteria in lung transplant recipients
    Chest (IF 9.657) Pub Date : 2020-04-02
    Takashi Hirama; Lianne G. Singer; Sarah K. Brode; Theodore K. Marras; Shahid Husain

    Owing to advanced respiratory disease among lung transplant (LTX) candidates, some could develop nontuberculous mycobacteria-pulmonary disease (NTM-PD). However, the appropriate management of NTM-PD found at the time of LTX is not clear. We, therefore, established a management protocol for peri-transplant NTM-PD, defined by the presence of granulomas and mycobacteriologic evidence of NTM in the explant

    更新日期:2020-04-03
  • Undiagnosed Obstructive Sleep Apnea May Significantly Impact Outcomes in Adults Admitted for COPD in an Inner-City Hospital
    Chest (IF 9.657) Pub Date : 2020-04-02
    Mario Naranjo; Leslee Willes; Barbara A. Prillaman; Stuart F. Quan; Sunil Sharma

    Background Chronic Obstructive Pulmonary Disease (COPD) is the second most common cause of hospital admission in the United States. Obstructive sleep apnea (OSA) is a highly prevalent and underdiagnosed condition which may impact the outcome of COPD. We hypothesized that presence of unrecognized and untreated OSA will increase hospital readmissions in patients admitted for COPD exacerbation. Methods

    更新日期:2020-04-03
  • Emerging Concepts of the Pathophysiology and Adverse Outcomes of Restless Legs Syndrome
    Chest (IF 9.657) Pub Date : 2020-04-02
    Sofía Romero; Irene Cano-Pumarega; Diego García-Borreguero

    Restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED), is a common neurological disorder affecting up to 5-10% of the population, but it still remains an underdiagnosed condition. RLS/WED is characterized by uncomfortable sensations, mainly in the legs, which appear during inactivity and worsen in the evening or at night. The prevalence of RLS/WED and periodic leg movements (PLMs)

    更新日期:2020-04-03
  • Combined treatment with hydrocortisone, vitamin C, and thiamine for sepsis and septic shock (HYVCTTSSS): A randomized controlled clinical trial
    Chest (IF 9.657) Pub Date : 2020-03-31
    Ping Chang; Yuping Liao; Jianbin Guan; Yuexun Guo; Ming Zhao; Jianmin Hu; Jian Zhou; Hua Wang; Zhongran Cen; Ying Tang; Zhanguo Liu

    Background Whether hydrocortisone, vitamin C, and thiamine treatment can reduce the mortality of patients with sepsis is controversial. Research Question To evaluate the efficacy and safety of hydrocortisone, vitamin C, and thiamine combination treatment for patients with sepsis or septic shock Study Design And Methods This single-blind, randomized controlled trial evaluated treatment with hydrocortisone

    更新日期:2020-04-01
  • Long term noninvasive ventilation in the Geneva Lake area: indications, prevalence and modalities
    Chest (IF 9.657) Pub Date : 2020-03-31
    C. Cantero; D. Adler; P. Pasquina; C. Uldry; B. Egger; M. Prella; A.B. Younossian; P. Gasche; J.L. Pépin; J.P. Janssens

    Background Noninvasive ventilation (NIV) is standard of care for chronic hypercapnic respiratory failure but indications, devices and ventilatory modes are in constant evolution. Research question To describe changes in prevalence, and indications for NIV over a 15 year period; to provide a comprehensive report of characteristics of the population treated (age, comorbidities, anthropometric data),

    更新日期:2020-04-01
  • Treatment with convalescent plasma for critically ill patients with SARS-CoV-2 infection
    Chest (IF 9.657) Pub Date : 2020-03-31
    Bin Zhang; Shuyi Liu; Tan Tan; Wenhui Huang; Yuhao Dong; Luyan Chen; Qiuying Chen; Lu Zhang; Qingyang Zhong; Xiaoping Zhang; Yujian Zou; Shuixing Zhang

    As of March 24, 2020, novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for 379,661 infection cases with 16,428 deaths globally and the number is still increasing rapidly. Herein, we presented four critically ill patients with SARS-CoV-2 infection who received supportive care and convalescent plasma. Although all the four patients (including a pregnant woman) recovered

    更新日期:2020-03-31
  • Echocardiography-derived stroke volume index is associated with adverse in-hospital outcomes in intermediate-risk acute pulmonary embolism: a retrospective cohort study
    Chest (IF 9.657) Pub Date : 2020-03-31
    Graeme Prosperi-Porta; Kevin Solverson; Nowell Fine; Christopher J. Humphreys; André Ferland; Jason Weatherald

    Background There remains uncertainty in the optimal prognostication and management of patients with intermediate-risk PE. Transthoracic echocardiography can identify right ventricular (RV) dysfunction to recognise intermediate-high risk patients. Research Question The aim of this study was to test whether echocardiography-derived stroke volume index (SVI) is associated with death or cardiopulmonary

    更新日期:2020-03-31
  • The Association of ICU Acuity with Adherence to ICU Evidence-Based Processes of Care
    Chest (IF 9.657) Pub Date : 2020-03-27
    Kelly C. Vranas; Jennifer Y. Scott; Omar Badawi; Michael O. Harhay; Christopher G. Slatore; Donald R. Sullivan; Meeta Prasad Kerlin

    Background Admission to high-acuity intensive care units (ICUs) has been associated with improved outcomes compared to low-acuity ICUs, although the mechanism for these findings is unclear. Research Question Do high-acuity ICUs more effectively implement evidence-based processes of care that have been associated with improved clinical outcomes? Study Design and Methods We performed a retrospective

    更新日期:2020-03-28
  • Place of Death for Individuals with Chronic Lung Disease: Trends and Associated Factors from 2003 to 2017 in the United States
    Chest (IF 9.657) Pub Date : 2020-03-27
    Sarah H. Cross; E. Wesley Ely; Dio Kavalieratos; James A. Tulsky; Haider J. Warraich

    Background Chronic lung disease is a common cause of mortality, yet little is known about where individuals with chronic lung disease die. Research Question What are the trends and factors associated with place of death among individuals with chronic lung disease? Study Design and Methods We conducted a cross-sectional analysis of natural deaths using the Centers for Disease Control and Prevention

    更新日期:2020-03-28
  • EFFECTIVENESS AND SAFETY OF SUPERVISED HOME-BASED PHYSICAL TRAINING IN PATIENTS WITH COPD ON LONG-TERM HOME OXYGEN THERAPY: A RANDOMIZED TRIAL
    Chest (IF 9.657) Pub Date : 2020-03-27
    Demetria Kovelis; Anna R.S. Gomes; Camila Mazzarin; Samia k. Biazim; Fabio Pitta; Silvia Valderramas

    Background Patients with chronic obstructive pulmonary disease (COPD) in advanced disease stage who need long-term home oxygen therapy (LTHOT) have difficulty participating in outpatient pulmonary rehabilitation (PR) programs due to the severity of their disease, limitations involving transportation and mobility, high costs and issues related to patients’ safety and individual needs. Unsupervised home-based

    更新日期:2020-03-28
  • Comparison of Hospitalized Patients with Acute Respiratory Distress Syndrome Caused by COVID-19 and H1N1
    Chest (IF 9.657) Pub Date : 2020-03-26
    Xiao Tang; Ronghui Du; Rui Wang; Tanze Cao; Lulu Guan; Chengqing Yang; Qi Zhu; Ming Hu; Xuyan Li; Ying Li; Lirong Liang; Zhaohui Tong; Bing Sun; Peng Peng; Huanzhong Shi

    Background Since the outbreak of Coronavirus Disease 2019 (COVID-19) in China in December 2019, considerable attention has been focused on its elucidation. However, it is also important for clinicians and epidemiologists to differentiate COVID-19 from other respiratory infectious diseases, such as influenza viruses. Research question The aim of the study was to explore the different clinical presentations

    更新日期:2020-03-27
  • Obstructive sleep apnea and neurocognitive impairment in children with congenital heart disease
    Chest (IF 9.657) Pub Date : 2020-03-25
    Daniel Combs; Jamie O. Edgin; Scott Klewer; Brent J. Barber; Wayne J. Morgan; Chiu-Hsieh Hsu; Ivo Abraham; Sairam Parthasarathy

    Background Children with congenital heart disease (CHD) have an increased risk of neurocognitive impairment. No prior studies have evaluated the role of obstructive sleep apnea (OSA), which is associated with neurocognitive impairment in children without CHD. Research Question Is OSA is associated with neurocognitive impairment in children with CHD? Study Design and Methods Children age 6-17 years

    更新日期:2020-03-26
  • Abnormal Pulmonary Lymphatic Flow in Patients with Lymphatic Anomalies and Respiratory Compromise
    Chest (IF 9.657) Pub Date : 2020-03-24
    Maxim Itkin; Deborah Rabinowitz; Gregory Nadolski; Patrick Stafler; Leo Mascarenas; Denise Adams

    Background Pulmonary involvement in lymphatic anomalies (LA) is associated with significant morbidity and mortality. Recently described Dynamic Contrast Enhanced Magnetic Resonance lymphangiography (DCMRL) is capable of imaging the lymphatic system in a variety of pulmonary lymphatic disorders. Research Question The objective of this study is to describe the central lymphatic anatomy in patients with

    更新日期:2020-03-26
  • Isolated pulmonary embolism is associated with a high risk of arterial thrombotic disease – Results from the VTEval Study
    Chest (IF 9.657) Pub Date : 2020-03-23
    Vincent ten Cate; Lisa Eggebrecht; Andreas Schulz; Marina Panova-Noeva; Michael Lenz; Thomas Koeck; Steffen Rapp; Natalie Arnold; Karl J. Lackner; Stavros Konstantinides; Christine Espinola-Klein; Thomas Münzel; Jürgen H. Prochaska; Philipp S. Wild

    Background Isolated PE is associated with a higher burden of atherosclerotic disease than other manifestations of venous thromboembolism (VTE). Research question We hypothesized that the presence of isolated PE may signal a chronically elevated risk of arterial thrombotic disease. Study Design and Methods Data from the VTEval Study, a prospective cohort study enrolling individuals with clinical suspicion

    更新日期:2020-03-26
  • Randomized trial on the effects of high-dose zopiclone on OSA severity, upper airway physiology and alertness
    Chest (IF 9.657) Pub Date : 2020-03-18
    Sophie G. Carter; Jayne C. Carberry; Ronald R. Grunstein; Danny J. Eckert

    Background Recent studies indicate that standard doses of hypnotics reduce or do not change the apnea-hypopnea index (AHI) or pharyngeal muscle activity. A 1-month trial of nightly zopiclone (7.5mg) modestly reduced the AHI versus baseline without changing other sleep parameters or next-day sleepiness. Research question This study aimed to determine the effects of high-dose zopiclone (15mg) on AHI

    更新日期:2020-03-19
  • Association between participant contact attempts and reports of being bothered in a national, longitudinal cohort study of ARDS survivors
    Chest (IF 9.657) Pub Date : 2020-03-17
    Michelle N. Eakin; Thomas Eckmann; Victor D. Dinglas; Ayodele A. Akinremi; Megan Hosey; Ramona O. Hopkins; Dale M. Needham

    Background Participant retention is a major challenge in clinical research, especially in studies with multiple, longitudinal research assessments Despite the importance of retention methods, there is little empirical research on how cohort retention efforts are perceived by study participants. Research Question To evaluate the association between the number of attempts undertaken to contact participants

    更新日期:2020-03-19
  • Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis.
    Chest (IF 9.657) Pub Date : 2020-03-17
    Jose Iglesias; Andrew V. Vassallo; Vishal V. Patel; Jesse B. Sullivan; Joseph Cavanaugh; Yasmine Elbaga

    Background Sepsis is a major public health burden resulting in 25-30% in-hospital mortality and accounting for over 20 billion dollars of United States hospital costs. Methods This was a randomized, double-blinded, placebo controlled trial conducted from February 2018 to June 2019 assessing an ascorbic acid (AA), thiamine, and hydrocortisone (HAT) treatment bundle for the management of septic and septic

    更新日期:2020-03-19
  • Diagnostic accuracy of thoracic ultrasonography to differentiate transudative from exudative pleural effusion
    Chest (IF 9.657) Pub Date : 2020-03-17
    Boris Shkolnik; Marc A. Judson; Adam Austin; Kurt Hu; Melissa D’souza; Alexis Zumbrunn; John T. Huggins; Recai Yucel; Amit Chopra

    Background There are limited data examining the diagnostic accuracy of thoracic ultrasonography (TUS) in distinguishing transudative from exudative pleural effusions. Research Question What is the diagnostic accuracy of TUS in distinguishing transudative from exudative effusions in consecutive patients with pleural effusion? Study Design and Methods Consecutive patients who underwent TUS and subsequently

    更新日期:2020-03-19
  • Diffusing Capacity is an Independent Predictor of Outcomes in Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease
    Chest (IF 9.657) Pub Date : 2020-03-14
    Aparna Balasubramanian; Todd M. Kolb; Rachel L. Damico; Paul M. Hassoun; Meredith C. McCormack; Stephen C. Mathai

    Background Patients with chronic obstructive pulmonary disease (COPD) who develop pulmonary hypertension (PH) have worse mortality than those with COPD alone. Predictors of poor outcomes in COPD-PH are not well described. Diffusing capacity of the lung (DLCO) assesses the integrity of the alveolar-capillary interface and thus may be a useful prognostic tool among those with COPD-PH. Research Question

    更新日期:2020-03-16
  • INCREASED CHITOTRIOSIDASE IS ASSOCIATED WITH ASPERGILLUS AND FREQUENT EXACERBATIONS IN SOUTH-EAST ASIANS WITH BRONCHIECTASIS
    Chest (IF 9.657) Pub Date : 2020-03-14
    Tuang Yeow Poh; Pei Yee Tiew; Albert Yick Hou Lim; Kai Xian Thng; Nur A'tikah Binte Mohamed Ali; Jayanth Kumar Narayana; Micheál Mac Aogáin; Zhijun Tien; Wui Mei Chew; Adrian Kwok Wai Chan; Holly R. Keir; Alison J. Dicker; Tidi Maharani Hassan; Huiying Xu; Augustine K.H. Tee; Thun How Ong; Mariko Siyue Koh; John Arputhan Abisheganaden; Sanjay H. Chotirmall

    Background and Research Question: Chitinase activity is an important innate immune defence mechanism against infection including fungi. The two human chitinases: chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase) are associated to allergy, asthma and chronic obstructive pulmonary disease (COPD), however, their role in bronchiectasis and bronchiectasis-COPD overlap (BCO) is unknown Study

    更新日期:2020-03-16
  • Derivation and Validation of a Diagnostic Prediction Tool for Interstitial Lung Disease
    Chest (IF 9.657) Pub Date : 2020-03-14
    Janelle Vu Pugashetti; Aleksander Kitich; Shehabaldin Alqalyoobi; Anne-Catherine Maynard-Paquette; David Pritchard; Julia Graham; Noelle Boctor; Andrea Kulinich; Elyse Lafond; Elena Foster; Cesar Mendez; Saad Choudhry; Jean Chalaoui; Julie Morisset; Michael Kadoch; Justin M. Oldham

    Background Interstitial lung disease (ILD) results in high morbidity and healthcare utilization. Diagnostic delays remain common and often occur in non-pulmonology settings. Screening for ILD in these settings has the potential to reduce diagnostic delays and improve patient outcomes. Research Question Can a pulmonary function test (PFT)-derived diagnostic prediction tool (ILD-Screen) accurately identify

    更新日期:2020-03-16
  • Minimal clinically important differences for patient-reported outcome measures of fatigue in patients with COPD after pulmonary rehabilitation.
    Chest (IF 9.657) Pub Date : 2020-03-14
    Patrícia Rebelo; Ana Oliveira; Lília Andrade; Carla Valente; Alda Marques

    Background Fatigue is a burdensome and prevailing symptom in patients with chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation (PR) improves fatigue however, interpreting when such improvement is clinically relevant is challenging. Minimal clinically important differences (MCIDs) for instruments assessing fatigue are warranted to better tailor PR and guide clinical decisions. We

    更新日期:2020-03-16
  • Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report
    Chest (IF 9.657) Pub Date : 2020-03-14
    Anne B. Chang; John J. Oppenheimer; Richard S. Irwin

    Background Cough is one of the most common presenting symptoms to general practitioners. The objective of this article is to collate the pediatric components of the CHEST chronic cough guidelines that have recently updated the 2006 guidelines to assist general and specialist medical practitioners in the evaluation and management of children who present with chronic cough. Methods We reviewed all current

    更新日期:2020-03-16
  • Mortality of cardiovascular events in COPD patients with preceding hospitalized acute exacerbation
    Chest (IF 9.657) Pub Date : 2020-03-14
    Mai Wang; Emily Pei-Ying Lin; Li-Ching Huang; Chung-Yi Li; Yu Shyr; Chao-Han Lai

    Background Acute exacerbation (AE) of chronic obstructive pulmonary disease (COPD) may be accompanied by the deterioration of cardiovascular comorbidities, as evidenced by the increased incidence of acute cardiovascular events. Research Question Whether preceding AE might be associated with mortality of cardiovascular events remains unknown. Study Design and Methods Using a health insurance research

    更新日期:2020-03-16
  • Pulmonary vascular and right ventricular burden during exercise in interstitial lung disease
    Chest (IF 9.657) Pub Date : 2020-03-12
    Rudolf K.F. Oliveira; Aaron B. Waxman; Paul J. Hoover; Paul F. Dellaripa; David M. Systrom

    Background Pulmonary hypertension (PH) adversely impact patient´s exercise capacity in interstitial lung disease (ILD). Pulmonary vascular and right ventricular (RV) dysfunction impact, however, have traditionally been thought to be mild, and clinically relevant principally in advanced lung disease states. We sought to evaluate the relative contributions of pulmonary mechanics, pulmonary vascular and

    更新日期:2020-03-12
  • Change in V̇O2peak in response to aerobic exercise training and the relationship with exercise prescription in people with COPD: A systematic review and meta-analysis
    Chest (IF 9.657) Pub Date : 2020-03-12
    Thomas J.C. Ward; Charles D. Plumptre; Thomas E. Dolmage; Amy V. Jones; Ruth Trethewey; Pip Divall; Sally J. Singh; Martin R. Lindley; Michael C. Steiner; Rachael A. Evans

    Background We investigated the effect of aerobic training and exercise prescription on peak oxygen uptake (V̇O2peak) in COPD. Methods A systematic review was performed using MEDLINE, EMBASE, CINAHL and Cochrane databases for all studies measuring V̇O2peak before and after supervised lower limb aerobic training in COPD (PROSPERO CRD42018099300). A random effects meta-analysis limited to randomised controlled

    更新日期:2020-03-12
  • Maternal distress during pregnancy and recurrence in early childhood predicts atopic dermatitis and asthma in childhood
    Chest (IF 9.657) Pub Date : 2020-03-12
    Aaron P. van der Leek; Salma Bahreinian; Mariette Chartier; Matt Dahl; Meghan B. Azad; Marni D. Brownell; Anita L. Kozyrskyj

    Methods Using data from a provincial newborn screen and healthcare database for 12,587 children born in 2004, maternal distress was defined as: prenatal, and self-limiting, recurrent or late-onset postpartum. Atopic dermatitis (AD) and asthma at ages 5 and 7 were diagnosed from hospitalization, physician visit or prescription records. Associations between maternal distress, and childhood asthma and

    更新日期:2020-03-12
  • Pulmonary Hypertension by the Method of Paul Wood
    Chest (IF 9.657) Pub Date : 2020-03-06
    John H. Newman

    A physiological approach to the analysis of hemodynamic data in pulmonary hypertension (PH) has the advantage of reducing the large number (well over 100) of potential causal illnesses into four simple mechanisms. A fifth condition is composed of mixtures of the four basic mechanisms. This approach was beautifully described by Paul Wood, the great cardiologist whose name is given to the units of pulmonary

    更新日期:2020-03-06
  • Update on Persistent Excessive Daytime Sleepiness in Obstructive Sleep Apnea
    Chest (IF 9.657) Pub Date : 2020-03-06
    Sogol Javaheri; Shahrokh Javaheri

    Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder and subjective excessive daytime sleepiness (EDS) is the cardinal symptom for which many individuals seek medical advice. Positive airway pressure (PAP) devices, first line treatment for OSA, eliminates EDS in most patients. However, a subset of patients suffers from persistent EDS despite adherence to therapy. Multiple conditions,

    更新日期:2020-03-06
  • Effect of Cefepime on Neurotoxicity Development in Critically Ill Adults with Renal Dysfunction
    Chest (IF 9.657) Pub Date : 2020-03-06
    Attiya Khan; Joshua M. DeMott; Christy Varughese; Drayton A. Hammond

    Background Pharmacodynamic and pathophysiologic changes in critically ill adults receiving cefepime may increase the risk of adverse events. This study evaluated the impact of cefepime exposure on neurotoxicity development in critically ill adults with renal dysfunction. Methods Critically ill adults with creatinine clearance <60 mL/min who received cefepime for ≥48 hours between 1 January 2014 and

    更新日期:2020-03-06
  • Bruxism Relieved Under CPAP Treatment in a Patient With OSA Syndrome
    Chest (IF 9.657) Pub Date : 2020-03-04
    Jean-Benoit Martinot; Jean-Christian Borel; Nhat-Nam Le-Dong; Philip E. Silkoff; Stephane Denison; David Gozal; Jean-Louis Pépin

    Bruxism is a heterogeneous condition related to various underlying mechanisms, including the presence of OSA. This case report illustrates that sleep mandibular movement monitoring and analysis could provide a useful opportunity for detection of both sleep bruxism and respiratory effort. The current case suggests that tracking of respiratory effort could enable evaluation of bruxism and its potential

    更新日期:2020-03-04
  • Acute Respiratory Failure Associated With Vaping
    Chest (IF 9.657) Pub Date : 2020-03-04
    Craig Fryman; Becky Lou; Andrew G. Weber; Harry N. Steinberg; Sameer Khanijo; Annamaria Iakovou; Mina R. Makaryus

    The use of e-cigarettes to deliver aerosolized nicotine has gained popularity in recent years. Numerous reports have cited the development of acute pulmonary disease linked to vaping nicotine as well as marijuana-based products. As cultural attitudes evolve and policies shift toward the legalization of marijuana, its use has become more prevalent. Given the increased prevalence of marijuana consumption

    更新日期:2020-03-04
  • A 46-Year-Old Woman With a Mediastinal Mass
    Chest (IF 9.657) Pub Date : 2020-03-04
    Uddalak Majumdar; Carol F. Farver; Atul C. Mehta

    Case Presentation A 46-year-old otherwise healthy woman visited the ED twice over a period of 4 days for chest discomfort, midback pain, and dyspnea. The pain was localized, constant, nonpleuritic in nature, moderate in severity, and was not relieved by over-the-counter medications.

    更新日期:2020-03-04
  • A 62-Year-Old Woman With Diffuse Myalgias, Fatigue, and Shortness of Breath
    Chest (IF 9.657) Pub Date : 2020-03-04
    Bryan D. Park; Kenneth Lyn-Kew; Ann Granchelli; Anuj Mehta

    Case Presentation A 62-year-old woman with a history of partially treated Graves disease and hypertension presented with approximately 3 weeks of worsening fatigue, lower extremity myalgias, and shortness of breath. Her medical history included a thyroid radiofrequency ablation several years earlier. Following the ablation, she was found to have some residual thyroid activity, negating the need for

    更新日期:2020-03-04
  • A 78-Year-Old Man With Recurrent Hemoptysis and Persistent Pulmonary Nodule
    Chest (IF 9.657) Pub Date : 2020-03-04
    Si Yuan Chew; Chien Sheng Tan; Youxin Puan; Jansen Meng Kwang Koh

    Case Presentation A 78-year-old Chinese man presented in March 2019 with a 2-day history of small-volume hemoptysis. He did not report any associated chronic cough, sputum production, epistaxis, night sweats, unintentional weight loss, or fever. He was an ex-smoker of 10 pack years. His medical history was significant for ischemic heart disease on aspirin, as well as hospitalizations in 2016 and 2017

    更新日期:2020-03-04
  • An 80-Year-Old Woman With a Solitary Pulmonary Nodule
    Chest (IF 9.657) Pub Date : 2020-03-04
    Jean-Baptiste Gibier; Magali Colombat; Nathalie Grardel; Marie de Charette; Ophélie Ouennoure; Rias Akkad; Marie-Christine Copin

    Case Presentation An 80-year-old-woman was referred for evaluation of chest pain that appeared after providing care at home for her sick husband, which included helping him to get up and move about. The pain was initially triggered by lifting heavy objects but then became constant, without exacerbating or relieving factors. The pain was located in the left hemithorax and was not associated with shortness

    更新日期:2020-03-04
  • Financial Justification for Interventional Pulmonology Programs: Terminology and Programmatic Models
    Chest (IF 9.657) Pub Date : 2020-03-04
    Amit K. Mahajan; Jennifer Bautista; Erin Hodson; Sandeep J Khandhar; Erik Folch; Susan Carroll; Steve Narang

    Interventional pulmonology programs provide clinical benefit to patients and are financially sustainable. In order to appreciate and illustrate the economic value of interventional pulmonology programs to hospital systems, physicians must have an understanding of basic healthcare finance. Total revenue, adjusted gross revenue, contribution margin, variable direct costs, and indirect costs are terms

    更新日期:2020-03-04
  • Risk factors of infectious complications after endobronchial ultrasound-guided transbronchial biopsy
    Chest (IF 9.657) Pub Date : 2020-03-04
    Tomohide Souma; Tomoyuki Minezawa; Hiroshi Yatsuya; Takuya Okamura; Kumiko Yamatsuta; Sayako Morikawa; Tomoya Horiguchi; Shingo Maeda; Yasuhiro Goto; Masamichi Hayashi; Sumito Isogai; Naoki Yamamoto; Masashi Kondo; Kazuyoshi Imaizumi

    Background Infectious complications after endobronchial ultrasound-guided transbronchial biopsy with a guide sheath (EBUS-GS-TBB) are serious in that they may delay or change scheduled subsequent therapy. The aim of this study was to identify risk factors for infection after EBUS-GS-TBB. Methods We retrospectively reviewed the medical records of 1,045 consecutive patients who had undergone EBUS-GS-TBB

    更新日期:2020-03-04
  • Who May Benefit from Diuretics in OSA? A Propensity Score-Match Observational Study.
    Chest (IF 9.657) Pub Date : 2020-02-28
    B Revol,I Jullian-Desayes,S Bailly,R Tamisier,Y Grillet,M Sapène,M Joyeux-Faure,J L Pépin,

    BACKGROUND Diuretics have been reported as effective for reducing obstructive sleep apnea (OSA) severity by preventing fluid retention and reducing rostral fluid shift. The benefit of diuretics might vary depending upon the OSA clinical phenotype and comorbidities. To test this hypothesis, we conducted a propensity score-matched cohort analysis of data from the French national sleep apnea registry

    更新日期:2020-03-02
  • Simulation Training for Critical Care Airway Management: Assessing Translation to Clinical Practice Using a Small Video Recording Device.
    Chest (IF 9.657) Pub Date : 2020-02-27
    Ronak T Shah,Mina R Makaryus,Rohit Kumar,Effie Singas,Paul H Mayo

    BACKGROUND Critical care airway management (CCAM) is a key skill for critical care physicians. Simulation based training (SBT) may be an effective modality in training intensivists in CCAM. RESEARCH QUESTION This study examines whether SBT of critical care fellows is an effective means of providing training in CCAM, with focus on urgent endotracheal intubation. STUDY DESIGN and Methods: A total of

    更新日期:2020-02-28
  • Ambulatory oxygen in fibrotic ILD: a pilot, randomised, triple-blinded, sham-controlled trial.
    Chest (IF 9.657) Pub Date : 2020-02-27
    Yet H Khor,Anne E Holland,Nicole Sl Goh,Belinda R Miller,Ross Vlahos,Steven Bozinovski,Aroub Lahham,Ian Glaspole,Christine F McDonald

    BACKGROUND Despite a lack of evidence, ambulatory oxygen therapy is frequently prescribed for patients with interstitial lung disease (ILD) and exertional desaturation. Patients often prefer portable oxygen concentrators to oxygen cylinders. This study aimed to examine the feasibility of conducting a clinical trial of ambulatory oxygen delivered via portable concentrators in patients with ILD. METHODS

    更新日期:2020-02-28
  • Independent validation of early-stage NSCLC prognostic scores incorporating epigenetic and transcriptional biomarkers with gene-gene interactions and main effects.
    Chest (IF 9.657) Pub Date : 2020-02-27
    Ruyang Zhang,Chao Chen,Xuesi Dong,Sipeng Shen,Linjing Lai,Jieyu He,Dongfang You,Lijuan Lin,Ying Zhu,Hui Huang,Jiajin Chen,Liangmin Wei,Xin Chen,Yi Li,Yichen Guo,Weiwei Duan,Liya Liu,Li Su,Andrea Shafer,Thomas Fleischer,Maria Moksnes Bjaanæs,Anna Karlsson,Maria Planck,Rui Wang,Johan Staaf,Åslaug Helland,Manel Esteller,Yongyue Wei,Feng Chen,David C Christiani

    BACKGROUND DNA methylation and gene expression are promising biomarkers of various cancers, including non-small cell lung cancer (NSCLC). Besides main effects of biomarkers, the progression of complex diseases is also influenced by gene-gene (GxG) interactions. Screening the functional capacity of biomarkers based on main effects or interactions using multi-omics data may improve the accuracy of cancer

    更新日期:2020-02-28
  • Alternative Splicing of the Cardiac Sodium Channel in Pulmonary Arterial Hypertension.
    Chest (IF 9.657) Pub Date : 2020-02-26
    Debasree Banerjee,Tom N Grammatopoulos,Amy Palmisciano,James R Klinger,Ipsita Krishnan,Mary Whittenhall,Anyu Zhou,Samuel Dudley,Corey E Ventetuolo

    更新日期:2020-02-26
  • Use of combined do-not-resuscitate/do-not intubate orders without documentation of intubation preferences: a retrospective observational study at an academic Level 1 trauma center.
    Chest (IF 9.657) Pub Date : 2020-02-25
    Jeffrey B Rubins

    BACKGROUND Combining orders for do-not-resuscitate (DNR) for cardiac arrest with do-not-intubate (DNI) orders into a DNR/DNI code status is not evidence-based practice and may violate patient autonomy and informed consent when providers discuss intubation only in the context of CPR. RESEARCH QUESTION How often do providers refer to patients with a DNR order as "DNR/DNI" without documentation of refusal

    更新日期:2020-02-25
  • Outcomes of Pulmonary Arterial Hypertension are Improved in a Specialty Care Center.
    Chest (IF 9.657) Pub Date : 2020-02-25
    Hongyang Pi,Chad M Kosanovich,Adam Handen,Michael Tao,Jacqueline Visina,Gabrielle Vanspeybroeck,Marc A Simon,Michael G Risbano,Aken Desai,Michael A Mathier,Belinda N Rivera-Lebron,Quyen Nguyen,Jennifer Kliner,Mehdi Nouraie,Stephen Y Chan

    BACKGROUND Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary arterial pressures managed by vasodilator therapies. Current guidelines encourage PAH management in specialty care centers (SCCs), but evidence is sparse regarding improvement in clinical outcomes and correlation to vasodilator use with referral. We hypothesize that PAH management at SCCs is associated with improved

    更新日期:2020-02-25
  • Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report.
    Chest (IF 9.657) Pub Date : 2020-02-24
    Mark A Malesker,Priscilla Callahan-Lyon,J Mark Madison,Belinda Ireland,Richard S Irwin,

    BACKGROUND Chronic cough due to chronic bronchitis (CB) causes significant impairment in quality of life and effective treatment strategies are needed. We conducted a systematic review on the management of chronic cough due to CB to update the recommendations and suggestions of the CHEST 2006 guideline on this topic. METHODS This systematic review asked three questions: 1. "What are the clinical features

    更新日期:2020-02-25
  • ‘HIGH RISK’ CLINICAL AND INFLAMMATORY CLUSTERS IN COPD OF CHINESE DESCENT
    Chest (IF 9.657) Pub Date : 2020-02-22
    Pei Yee Tiew; Fanny Wai San Ko; Jayanth Kumar Narayana; Mau Ern Poh; Huiying Xu; Han Yee Neo; Li-Cher Loh; Choo-Khoo Ong; Micheál Mac Aogáin; Jessica Han Ying Tan; Nabilah Husna Kamaruddin; Gerald Jiong Hui Sim; Therese S. Lapperre; Mariko Siyue Koh; David Shu Cheong Hui; John Arputhan Abisheganaden; Augustine Tee; Krasimira Tsaneva-Atanasova; Sanjay H. Chotirmall

    Introduction COPD is a heterogeneous disease demonstrating inter-individual variation. A high COPD prevalence in Chinese populations is described but little is known about disease clusters and prognostic outcomes in the Chinese population across South-East Asia. We aim to determine if clusters of Chinese patients with COPD exist and their association with systemic inflammation and clinical outcomes

    更新日期:2020-02-23
  • Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients:CHEST Expert Panel Report
    Chest (IF 9.657) Pub Date : 2020-02-21
    Maeve P. Smith; Mark Lown; Sonal Singh; Belinda Ireland; Adam T. Hill; Jeffrey A. Linder; Richard S. Irwin

    Background The evidence for the diagnosis and management of cough due to acute bronchitis in immunocompetent adult outpatients was reviewed as an update to the 2006 American College of Chest Physicians (ACCP) Evidence-Based Clinical Practice Guideline Cough due to Acute Bronchitis. Methods Acute bronchitis was defined as an acute lower respiratory tract infection manifested predominantly by cough with

    更新日期:2020-02-21
  • Diagnosis of EVALI: General Approach and the Role of Bronchoscopy
    Chest (IF 9.657) Pub Date : 2020-02-21
    Scott K. Aberegg; Sean D. Maddock; Denitza P. Blagev; Sean J. Callahan

    Case vignette A 23 year-old man arrives at the emergency department with a three week history of dyspnea, dry cough, fevers and night sweats. Two weeks previously, he was evaluated in an outpatient clinic and given a course of azithromycin for presumed infectious pneumonia. His symptoms did not improve and he was seen one week later in an urgent care center and given a prescription for doxycycline

    更新日期:2020-02-21
  • The Association between Air Pollution and Hospitalization of Patients with Idiopathic Pulmonary Fibrosis in Chile: A daily time series analysis.
    Chest (IF 9.657) Pub Date : 2020-02-21
    Robert Dales; Claudia Blanco-Vidal; Sabit Cakmak

    Background Idiopathic pulmonary fibrosis (IPF) causes progressive dyspnea, hypoxemia and death within a few years. Little is known about the effect of air pollution on disease exacerbations. Methods Hospital admissions for IPF are coded J84.1 by the International Classification of Disease, 10th Revision. Using ambient air pollution and climate data from seven air monitoring stations distributed in

    更新日期:2020-02-21
  • A Randomized, double-blind, placebo-controlled study to assess the safety and efficacy of pulsed, inhaled nitric oxide (iNO) at a dose of 30 mcg/kg-IBW/hr (iNO 30) in subjects at risk of Pulmonary Hypertension associated with Pulmonary Fibrosis (PH-PF) receiving Oxygen Therapy
    Chest (IF 9.657) Pub Date : 2020-02-21
    Steve.D. Nathan; Kevin.R. Flaherty; Marilyn.K. Glassberg; Ganesh Raghu; Jeffrey Swigris; Roger Alvarez; Neil Ettinger; Jim Loyd; Peter Fernandes; Hunter Gillies; Bo Kim; Parag Shah; Lisa Lancaster

    Purpose The interstitial lung diseases include a variety of disorders, many of which are characterized by fibrotic changes (fILD). Of the fILDs, Idiopathic Pulmonary Fibrosis (IPF) is the most common. Pulmonary hypertension (PH) frequently complicates fILD and is associated with impaired functional capability, lower physical activity and significantly reduced life expectancy. There is no proven treatment

    更新日期:2020-02-21
  • Better with Ultrasound: Detection of Deep Vein Thrombosis.
    Chest (IF 9.657) Pub Date : 2020-02-19
    Ariel L Shiloh,Christa McPhee,Lewis Eisen,Seth Koenig,Scott J Millington

    Ultrasound studies to detect deep vein thrombosis are traditionally performed and interpreted by sonographers and radiologists respectively, but the growth of point-of-care ultrasound is putting this powerful tool in the hands of front-line physicians. Literature from ambulatory patients in the emergency department suggests this tool performs well in the hands of nonconventional users, and it is now

    更新日期:2020-02-20
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
宅家赢大奖
向世界展示您的会议墙报和演示文稿
全球疫情及响应:BMC Medicine专题征稿
新版X-MOL期刊搜索和高级搜索功能介绍
化学材料学全球高引用
ACS材料视界
x-mol收录
自然科研论文编辑服务
南方科技大学
南方科技大学
西湖大学
中国科学院长春应化所于聪-4-8
复旦大学
课题组网站
X-MOL
深圳大学二维材料实验室张晗
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug