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Acne-induced pathological scars: pathophysiology and current treatments Burns Trauma (IF 5.3) Pub Date : 2024-04-06 Wanyu Xu, Dorsa Gholamali Sinaki, Yuchen Tang, Yunsheng Chen, Yixin Zhang, Zheng Zhang
Acne is a common chronic inflammatory dermatosis that can lead to pathological scars (PSs, divided into hypertrophic scars and keloids). These kinds of abnormal scars seriously reduce the quality of life of patients. However, their mechanism is still unclear, resulting in difficult clinical prevention, unstable treatment effects and a high risk of recurrence. Available evidence supports inflammatory
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Nocardia rubra cell-wall skeleton mitigates whole abdominal irradiation-induced intestinal injury via regulating macrophage function Burns Trauma (IF 5.3) Pub Date : 2024-03-05 Lingling Wu, Long Chen, Huijuan Li, Yawei Wang, Kexin Xu, Wanchao Chen, Aihua Zhang, Yu Wang, Chunmeng Shi
Background Ionizing radiation (IR)-induced intestinal injury is a major side effect and dose-limiting toxicity in patients receiving radiotherapy. There is an urgent need to identify an effective and safe radioprotectant to reduce radiation-induced intestinal injury. Immunoregulation is considered an effective strategy against IR-induced injury. The purpose of this article was to investigate the protective
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The role of the skin microbiome in wound healing Burns Trauma (IF 5.3) Pub Date : 2024-03-05 Yuyan Yang, Jiuzuo Huang, Ang Zeng, Xiao Long, Nanze Yu, Xiaojun Wang
The efficient management of skin wounds for rapid and scarless healing represents a major clinical unmet need. Nonhealing skin wounds and undesired scar formation impair quality of life and result in high healthcare expenditure worldwide. The skin-colonizing microbiota contributes to maintaining an intact skin barrier in homeostasis, but it also participates in the pathogenesis of many skin disorders
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Adipose mesenchymal stem cell-derived exosomes promote skin wound healing in diabetic mice by regulating epidermal autophagy Burns Trauma (IF 5.3) Pub Date : 2024-03-01 Zhe Wang, Haiyue Ren, Peng Su, Feng Zhao, Qiqi Zhang, Xing Huang, Cai He, Quan Wu, Zitong Wang, Jiajie Ma
Background Adipose mesenchymal stem cell-derived exosomes (ADSC-Exos) have great potential in the field of tissue repair and regenerative medicine, particularly in cases of refractory diabetic wounds. Interestingly, autophagy plays a role in wound healing, and recent research has demonstrated that exosomes are closely associated with intracellular autophagy in biogenesis and molecular signaling mechanisms
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Matrix metalloproteinase-8 regulates dendritic cell tolerance in late polymicrobial sepsis via the nuclear factor kappa-B p65/β-catenin pathway Burns Trauma (IF 5.3) Pub Date : 2024-02-29 Zhong-qiu Lu, Chen Zhang, Lin-jun Zhao, Wei Dong, Liang Lv, Yang Lu, Xiao-Yan Chen, Jie Zhang, Xin-yong Liu, Zhong Xiao, Long-wang Chen, Yong-ming Yao, Guang-ju Zhao
Background Tolerogenic dendritic cells (DCs) are associated with poor prognosis of sepsis. Matrix metalloproteinases (MMPs) have been shown to have immunomodulatory effects. However, whether MMPs are involved in the functional reprogramming of DCs is unknown. The study aims to investigate the role of MMPs in sepsis-induced DCs tolerance and the potential mechanisms. Methods A murine model of late sepsis
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Influence of scar age, laser type and laser treatment intervals on paediatric burn scars: a systematic review and meta-analysis Burns Trauma (IF 5.3) Pub Date : 2024-02-03 Yangmyung Ma, Sabrina P Barnes, Yung-Yi Chen, Naiem Moiemen, Janet M Lord, Amanda V Sardeli
Background Laser therapy has emerged to play a valuable role in the treatment of paediatric burn scars; however, there is heterogeneity in the literature, particularly concerning optimal timing for initiation of laser therapy. This study aims to investigate the effect of factors such as scar age, type of laser and laser treatment interval on burn scar outcomes in children by meta-analysis of previous
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The cGAS-STING pathway: a therapeutic target in diabetes and its complications Burns Trauma (IF 5.3) Pub Date : 2024-02-03 Wenjie He, Xingrui Mu, Xingqian Wu, Ye Liu, Junyu Deng, Yiqiu Liu, Felicity Han, Xuqiang Nie
Diabetic wound healing (DWH) represents a major complication of diabetes where inflammation is a key impediment to proper healing. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has emerged as a central mediator of inflammatory responses to cell stress and damage. However, the contribution of cGAS-STING activation to impaired healing in DWH remains understudied
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The impact of burn injury on the central nervous system Burns Trauma (IF 5.3) Pub Date : 2024-02-02 Amira Allahham, Grant Rowe, Andrew Stevenson, Mark W Fear, Ann-Maree Vallence, Fiona M Wood
Burn injuries can be devastating, with life-long impacts including an increased risk of hospitalization for a wide range of secondary morbidities. One area that remains not fully understood is the impact of burn trauma on the central nervous system (CNS). This review will outline the current findings on the physiological impact that burns have on the CNS and how this may contribute to the development
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Broadening horizons: ferroptosis as a new target for traumatic brain injury Burns Trauma (IF 5.3) Pub Date : 2024-01-21 Ziqing Wei, Haihan Yu, Huijuan Zhao, Mingze Wei, Han Xing, Jinyan Pei, Yang Yang, Kaidi Ren
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with ~50 million people experiencing TBI each year. Ferroptosis, a form of regulated cell death triggered by iron ion-catalyzed and reactive oxygen species-induced lipid peroxidation, has been identified as a potential contributor to traumatic central nervous system conditions, suggesting its involvement in the pathogenesis
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Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy Burns Trauma (IF 5.3) Pub Date : 2024-01-19 Yan Shi, Shang Wang, Dewu Liu, Zhengguang Wang, Yihan Zhu, Jun Li, Kui Xu, Furong Li, Huicai Wen, Ronghua Yang
Background Refractory diabetic wounds are a common occurrence in patients with diabetes and epidermis-specific macroautophagy/autophagy impairment has been implicated in their pathogenesis. Therefore, identifying and developing treatment strategies capable of normalizing epidermis-specific macroautophagy/autophagy could facilitate diabetic wound healing. The study aims to investigate the potential
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Metabolic reprogramming in skin wound healing Burns Trauma (IF 5.3) Pub Date : 2024-01-03 Zitong Wang, Feng Zhao, Chengcheng Xu, Qiqi Zhang, Haiyue Ren, Xing Huang, Cai He, Jiajie Ma, Zhe Wang
Metabolic reprogramming refers to the ability of a cell to alter its metabolism in response to different stimuli and forms of pressure. It helps cells resist external stress and provides them with new functions. Skin wound healing involves the metabolic reprogramming of nutrients, such as glucose, lipids, and amino acids, which play vital roles in the proliferation, differentiation, and migration of
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Inhibition of phosphatidylinositol 3-kinase catalytic subunit alpha by miR-203a-3p reduces hypertrophic scar formation via phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway Burns Trauma (IF 5.3) Pub Date : 2024-01-03 Shixin Zhao, Hengdeng Liu, Hanwen Wang, Xuefeng He, Jinming Tang, Shaohai Qi, Ronghua Yang, Julin Xie
Background Hypertrophic scar (HS) is a common fibroproliferative skin disease that currently has no truly effective therapy. Given the importance of phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) in hypertrophic scar formation, the development of therapeutic strategies for endogenous inhibitors against PIK3CA is of great interest. Here, we explored the molecular mechanisms underlying
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S-Nitrosylation-mediated coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent keloid formation Burns Trauma (IF 5.3) Pub Date : 2023-12-19 Dongming Lv, Zhongye Xu, Pu Cheng, Zhicheng Hu, Yunxian Dong, Yanchao Rong, Hailin Xu, Zhiyong Wang, Xiaoling Cao, Wuguo Deng, Bing Tang
Background Keloids are aberrant dermal wound healing characterized by invasive growth, extracellular matrix deposition, cytokine overexpression and easy recurrence. Many factors have been implicated as pathological causes of keloids, particularly hyperactive inflammation, tension alignment and genetic predisposition. S-Nitrosylation (SNO), a unique form of protein modification, is associated with the
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The clinical differentiation of blood culture-positive and -negative sepsis in burn patients: a retrospective cohort study Burns Trauma (IF 5.3) Pub Date : 2023-12-19 Jaechul Yoon, Dohern Kym, Jun Hur, Jongsoo Park, Myongjin Kim, Yong Suk Cho, Wook Chun, Dogeon Yoon
Background Sepsis is a potentially life-threatening condition that occurs when the body’s response to infection leads to widespread inflammation and tissue damage. Negative cultures can make it difficult for clinicians to make a diagnosis and may raise questions about the validity of the definition of sepsis. In addition, the clinical distinctions between burn patients with blood culture-positive and
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The impact of COVID-19 on clinical outcomes of burn patients Burns Trauma (IF 5.3) Pub Date : 2023-12-07 Elliot T Walters, Alen Palackic, Camila Franco-Mesa, Nikhil R Shah, Michael J Erickson, Steven E Wolf
Background Multiple studies have shown the SARS-CoV-2 virus (COVID-19) to be associated with deleterious outcomes in a wide range of patients. The impact of COVID-19 has not been well investigated among burned patients. We suspect that patients will have worsened respiratory and thrombotic complications, ultimately leading to increased mortality. The objective of this study is to determine the impact
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Plasma lipidomics reveal systemic changes persistent throughout early life following a childhood burn injury Burns Trauma (IF 5.3) Pub Date : 2023-12-07 Eva Kierath, Monique Ryan, Elaine Holmes, Jeremy K Nicholson, Mark W Fear, Fiona M Wood, Luke Whiley, Nicola Gray
Background Non-severe paediatric burns can result in poor long-term health outcomes. This occurs even in cases with good acute burn-related outcomes, including minimal scarring. The mechanisms that underpin the transition from non-severe burn to sustained negative long-term health impacts are currently unknown. However, sustained metabolic and immune changes have been observed in paediatric burn studies
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Regulated necrosis pathways: a potential target for ischemic stroke. Burns Trauma (IF 5.3) Pub Date : 2023-11-18 Kaidi Ren,Jinyan Pei,Yuanyuan Guo,Yuxue Jiao,Han Xing,Yi Xie,Yang Yang,Qi Feng,Jing Yang
Globally, ischemic stroke causes millions of deaths per year. The outcomes of ischemic stroke are largely determined by the amount of ischemia-related and reperfusion-related neuronal death in the infarct region. In the infarct region, cell injuries follow either the regulated pathway involving precise signaling cascades, such as apoptosis and autophagy, or the nonregulated pathway, which is uncontrolled
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Peptide RL-QN15 promotes wound healing of diabetic foot ulcers through p38 mitogen-activated protein kinase and smad3/miR-4482-3p/vascular endothelial growth factor B axis Burns Trauma (IF 5.3) Pub Date : 2023-11-17 Dandan Sun, Kun Guo, Naixin Liu, Yilin Li, Yuansheng Li, Yan Hu, Shanshan Li, Zhe Fu, Yinglei Wang, Yutong Wu, Yingxuan Zhang, Jiayi Li, Chao Li, Zhuo Wang, Zijian Kang, Jun Sun, Ying Wang, Xinwang Yang
Background Wound management of diabetic foot ulcers (DFUs) is a complex and challenging task, and existing strategies fail to meet clinical needs. Therefore, it is important to develop novel drug candidates and discover new therapeutic targets. However, reports on peptides as molecular probes for resolving issues related to DFUs remain rare. This study utilized peptide RL-QN15 as an exogenous molecular
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Extracellular vesicles modulate key signalling pathways in refractory wound healing Burns Trauma (IF 5.3) Pub Date : 2023-11-17 Bowen Yang, Yumeng Lin, Yibo Huang, Nanxi Zhu, Ying-Qiang Shen
Chronic wounds are wounds that cannot heal properly due to various factors, such as underlying diseases, infection or reinjury, and improper healing of skin wounds and ulcers can cause a serious economic burden. Numerous studies have shown that extracellular vesicles (EVs) derived from stem/progenitor cells promote wound healing, reduce scar formation and have significant advantages over traditional
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S100 calcium-binding protein A9 promotes skin regeneration through toll-like receptor 4 during tissue expansion Burns Trauma (IF 5.3) Pub Date : 2023-11-06 Yu Zhang, Yajuan Song, Jing Du, Wei Liu, Chen Dong, Zhaosong Huang, Zhe Zhang, Liu Yang, Tong Wang, Shaoheng Xiong, Liwei Dong, Yaotao Guo, Juanli Dang, Qiang He, Zhou Yu, Xianjie Ma
Background In plastic surgery, tissue expansion is widely used for repairing skin defects. However, low expansion efficiency and skin rupture caused by thin, expanded skin remain significant challenges in promoting skin regeneration during expansion. S100 calcium-binding protein A9 (S100A9) is essential in promoting wound healing; however, its effects on skin regeneration during tissue expansion remain
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CO2 fractional laser-assisted transdermal delivery of silk nanofiber carriers in a rabbit ear hypertrophic scar model Burns Trauma (IF 5.3) Pub Date : 2023-11-03 Yan Yang, Lutong Liu, Xiaojin Wu, Xue Wang, Qiang Lu, Zhen Zhang
Background Hypertrophic scars are skin fibrotic diseases, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix. However, topical drug application for hypertrophic scars are unsatisfactory. The purpose of this study was to explore the permeability of silk nanofiber hydrogels (SNFs) loaded with rhodamine 6G (R6G) and rhodamine 110 (R110) mediated by CO2 fractional
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Chinese expert consensus on the Management of Pediatric Deep Partial-Thickness Burn Wounds (2023 edition). Burns Trauma (IF 5.3) Pub Date : 2023-10-31 Yan Liu,
Burns are a main cause of accidental injuries among children in China. Because of the unique wound repair capacity and demand for growth in pediatric patients, the management of pediatric deep partial-thickness burn wounds involves a broader range of treatment options and controversy. We assembled experts from relevant fields in China to reach a consensus on the key points of thermal-induced pediatric
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In vitro comparison of human plasma-based and self-assembled tissue-engineered skin substitutes: two different manufacturing processes for the treatment of deep and difficult to heal injuries. Burns Trauma (IF 5.3) Pub Date : 2023-10-30 Álvaro Sierra-Sánchez,Brice Magne,Etienne Savard,Christian Martel,Karel Ferland,Martin A Barbier,Anabelle Demers,Danielle Larouche,Salvador Arias-Santiago,Lucie Germain
Background The aim of this in vitro study was to compare side-by-side two models of human bilayered tissue-engineered skin substitutes (hbTESSs) designed for the treatment of severely burned patients. These are the scaffold-free self-assembled skin substitute (SASS) and the human plasma-based skin substitute (HPSS). Methods Fibroblasts and keratinocytes from three humans were extracted from skin biopsies
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Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis. Burns Trauma (IF 5.3) Pub Date : 2023-10-30 Yunwei Wang,Kuo Shen,Yulin Sun,Peng Cao,Jia Zhang,Wanfu Zhang,Yang Liu,Hao Zhang,Yang Chen,Shaohui Li,Chaolei Xu,Chao Han,Yating Qiao,Qingyi Zhang,Bin Wang,Liang Luo,Yunshu Yang,Hao Guan
Background Non-healing wounds are an intractable problem of major clinical relevance. Evidence has shown that dermal papilla cells (DPCs) may regulate the wound-healing process by secreting extracellular vesicles (EVs). However, low isolation efficiency and restricted cell viability hinder the applications of DPC-EVs in wound healing. In this study, we aimed to develop novel 3D-DPC spheroids (tdDPCs)
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Tailored biomedical materials for wound healing. Burns Trauma (IF 5.3) Pub Date : 2023-10-26 Wenhui Liu,Lihua Zu,Shanzheng Wang,Jingyao Li,Xiaoyuan Fei,Meng Geng,Chunlei Zhu,Hui Shi
Wound healing is a long-term, multi-stage biological process that mainly includes haemostatic, inflammatory, proliferative and tissue remodelling phases. Controlling infection and inflammation and promoting tissue regeneration can contribute well to wound healing. Smart biomaterials offer significant advantages in wound healing because of their ability to control wound healing in time and space. Understanding
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P-MSC-derived extracellular vesicles facilitate diabetic wound healing via miR-145-5p/ CDKN1A-mediated functional improvements of high glucose-induced senescent fibroblasts Burns Trauma (IF 5.3) Pub Date : 2023-10-18 Jianlong Su, Qian Wei, Kui Ma, Yaxi Wang, Wenzhi Hu, Hao Meng, Qiankun Li, Yuehou Zhang, Wenhua Zhang, Haihong Li, Xiaobing Fu, Cuiping Zhang
Background Persistent hyperglycaemia in diabetes causes functional abnormalities of human dermal fibroblasts (HDFs), partially leading to delayed skin wound healing. Extracellular vesicles (EVs) containing multiple pro-healing microRNAs (miRNAs) have been shown to exert therapeutic effects on diabetic wound healing. The present study aimed to observe the effects of EVs derived from placental mesenchymal
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The m6A reader YTHDF2 alleviates the inflammatory response by inhibiting IL-6R/JAK2/STAT1 pathway-mediated high-mobility group box-1 release Burns Trauma (IF 5.3) Pub Date : 2023-10-16 Zhuo Zeng, Yingying Lan, Lijuan Zhang, Yu Chen, Yali Gong, Fangqing Zuo, Junda Li, Gaoxing Luo, Yizhi Peng, Zhiqiang Yuan
Background Sepsis is a common severe complication in major burn victims and is characterized by a dysregulated systemic response to inflammation. YTH domain family 2 (YTHDF2), a well-studied N6-methyladenosine (m6A) reader that specifically recognizes and binds to m6A-modified transcripts to mediate their degradation, is connected to pathogenic and physiological processes in eukaryotes, but its effect
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A photoactivatable and phenylboronic acid-functionalized nanoassembly for combating multidrug-resistant gram-negative bacteria and their biofilms Burns Trauma (IF 5.3) Pub Date : 2023-10-16 Xiaoqing Zhou, Lanlan Dong, Baohua Zhao, Guangyun Hu, Can Huang, Tengfei Liu, Yifei Lu, Mengxue Zheng, Yanlan Yu, Zengjun Yang, Shaowen Cheng, Yan Xiong, Gaoxing Luo, Wei Qian, Rui Yin
Background Multidrug-resistant (MDR) gram-negative bacteria-related infectious diseases have caused an increase in the public health burden and mortality. Moreover, the formation of biofilms makes these bacteria difficult to control. Therefore, developing novel interventions to combat MDR gram-negative bacteria and their biofilms-related infections are urgently needed. The purpose of this study was
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Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis Burns Trauma (IF 5.3) Pub Date : 2023-10-16 Ruzhen Zhang, Sheng Chen, Zhifan Yang, Ning Zhang, Kenan Guo, Keyi Lv, Zimo Zhou, Meijiao Gao, Xiancheng Hu, Yongping Su, Jianming He, Fengchao Wang
Background The rapid turnover of the intestinal epithelium is driven by the proliferation and differentiation of intestinal stem cells (ISCs). The dynamics of the F-actin cytoskeleton are critical for maintaining intercellular force and the signal transduction network. However, it remains unclear how direct interference with actin polymerization impacts ISC homeostasis. This study aims to reveal the
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Cell electrospinning and its application in wound healing: principles, techniques and prospects. Burns Trauma (IF 5.3) Pub Date : 2023-09-15 Zonghao Hu,Zishun Qin,Yue Qu,Feng Wang,Benheng Huang,Gaigai Chen,Xiaoyuan Liu,Lihua Yin
Currently, clinical strategies for the treatment of wounds are limited, especially in terms of achieving rapid wound healing. In recent years, based on the technique of electrospinning (ES), cell electrospinning (C-ES) has been developed to better repair related tissues or organs (such as skin, fat and muscle) by encapsulating living cells in a microfiber or nanofiber environment and constructing 3D
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Sustained induction of IP-10 by MRP8/14 via the IFNβ-IRF7 axis in macrophages exaggerates lung injury in endotoxemic mice. Burns Trauma (IF 5.3) Pub Date : 2023-09-11 Juan Wang,Guiming Chen,Lei Li,Sidan Luo,Bingrong Hu,Jia Xu,Haihua Luo,Shan Li,Yong Jiang
Background As a damage-associated molecular pattern, the myeloid-related protein 8/14 (MRP8/14) heterodimer mediates various inflammatory diseases, such as sepsis. However, how MRP8/14 promotes lung injury by regulating the inflammatory response during endotoxemia remains largely unknown. This study aims at illuminating the pathological functions of MRP8/14 in endotoxemia. Methods An endotoxemic model
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Cellular and molecular mechanisms in vascular repair after traumatic brain injury: a narrative review Burns Trauma (IF 5.3) Pub Date : 2023-09-05 Zi-Ai Zhao, Lingli Yan, Jing Wen, Senthil Kumaran Satyanarayanan, Feng Yu, Jiahong Lu, Yong U Liu, Huanxing Su
Traumatic brain injury (TBI) disrupts normal brain function and is associated with high morbidity and fatality rates. TBI is characterized as mild, moderate or severe depending on its severity. The damage may be transient and limited to the dura matter, with only subtle changes in cerebral parenchyma, or life-threatening with obvious focal contusions, hematomas and edema. Blood vessels are often injured
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Children’s growth and motor development following a severe burn: a systematic review Burns Trauma (IF 5.3) Pub Date : 2023-08-31 Maxime D Cuijpers, Martin G A Baartmans, Paul P M van Zuijlen, Johannes C F Ket, Anouk Pijpe
Background The epidemiological data on post-burn growth, body composition and motor development is ambiguous and scattered. The aim of this systematic review was therefore to summarize the current body of evidence on post-burn growth, body composition and motor development in children. Methods A literature search was conducted in PubMed, EMBASE and Web of Science up to March 2021. We considered observational
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Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcers Burns Trauma (IF 5.3) Pub Date : 2023-08-20 Hengyu Du, Shenghong Li, Jinqiang Lu, Lingzhi Tang, Xiao Jiang, Xi He, Jiaji Liang, Xuan Liao, Taixing Cui, Yuesheng Huang, Hongwei Liu
Background Angiogenesis is crucial in diabetic wound healing and is often impaired in diabetic foot ulcers (DFUs). Human dermal microvascular endothelial cells (HDMECs) are vital components in dermal angiogenesis; however, their functional and transcriptomic characteristics in DFU patients are not well understood. This study aimed to comprehensively analyse HDMECs from DFU patients and healthy controls
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p53 promotes the expansion of regulatory T cells via DNMT3a- and TET2- mediated Foxp3 expression in sepsis Burns Trauma (IF 5.3) Pub Date : 2023-08-09 Hui Zhang, Tiantian Wu, Chao Ren, Ning Dong, Yao Wu, Yongming Yao
Background Immunosuppression is an important characteristic of sepsis and is closely related to poor outcomes. Regulatory T cells (Tregs) contribute to immune suppression by inhibiting effector T cell (Teff) proliferation and differentiation. We aimed to investigate the role of p53 in Treg expansion after sepsis. Methods We constructed a sepsis model in wild-type (WT) and p53f/f/CD4-Cre+ mice by cecal
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Skin models of cutaneous toxicity, transdermal transport and wound repair Burns Trauma (IF 5.3) Pub Date : 2023-07-28 Inês Vilela de Sousa, Miguel J S Ferreira, Luís B Bebiano, Sandra Simões, Ana Filipa Matos, Rúben F Pereira, Pedro L Granja
Skin is widely used as a drug delivery route due to its easy access and the possibility of using relatively painless methods for the administration of bioactive molecules. However, the barrier properties of the skin, along with its multilayer structure, impose severe restrictions on drug transport and bioavailability. Thus, bioengineered models aimed at emulating the skin have been developed not only
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CD9 negatively regulates collective electrotaxis of the epidermal monolayer by controlling and coordinating the polarization of leader cells Burns Trauma (IF 5.3) Pub Date : 2023-07-24 Xiaoqiang Liu, Jinrui Yang, Meng Kong, Min Jiang, Luojia Liu, Jinghong Zhang, Ying Chen, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jie Liu, Jiaping Zhang
Background Endogenous electric fields (EFs) play an essential role in guiding the coordinated collective migration of epidermal cells to the wound centre during wound healing. Although polarization of leadercells is essential for collective migration, the signal mechanisms responsible for the EF-induced polarization of leader cells under electrotactic collective migration remain unclear. This study
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Vascularized lymph node flaps can survive on venous blood without an arterial inflow: an experimental model describing the dynamics of venous flow using indocyanine green angiography (With video) Burns Trauma (IF 5.3) Pub Date : 2023-07-19 Ke Li, Fabio Nicoli, Chunxiao Cui, Yan Wo, Ning Fei Liu, Shaoqing Feng, Wenjing Xi, Peiru Min, Yixin Zhang
Background Several surgeons have described studies of free-tissue transfers using veins instead of arteries. These innovative microsurgical techniques can offer several advantages, such as an easier dissection during flap harvesting, and represent an alternative during an accidental surgical mistake or development of new surgical procedures. The purpose of this study was to describe and explore different
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Mitochondrial dysfunction and mitophagy: crucial players in burn trauma and wound healing Burns Trauma (IF 5.3) Pub Date : 2023-07-17 Harshini Sheeja Prabhakaran, Dongxue Hu, Weifeng He, Gaoxing Luo, Yih-Cherng Liou
Burn injuries are a significant cause of death worldwide, leading to systemic inflammation, multiple organ failure and sepsis. The progression of burn injury is explicitly correlated with mitochondrial homeostasis, which is disrupted by the hyperinflammation induced by burn injury, leading to mitochondrial dysfunction and cell death. Mitophagy plays a crucial role in maintaining cellular homeostasis
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Wnt4 increases the thickness of the epidermis in burn wounds by activating canonical Wnt signalling and decreasing the cell junctions between epidermal cells. Burns Trauma (IF 5.3) Pub Date : 2023-07-03 Fei Xiang,Pei Wang,Hao Gong,Jia Luo,Xin Zhou,Chenglin Zhan,Tianxing Hu,Mengru Wang,Yizhan Xing,Haiying Guo,Gaoxing Luo,Yuhong Li
Background Burn wound healing is a complex process and the role of Wnt ligands varies in this process. Whether and how Wnt4 functions in burn wound healing is not well understood. In this study, we aim to reveal the effects and potential mechanisms of Wnt4 in burn wound healing. Methods First, the expression of Wnt4 during burn wound healing was determined by immunofluorescence, Western blotting and
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A volar skin excisional wound model for in situ evaluation of multiple-appendage regeneration and innervation Burns Trauma (IF 5.3) Pub Date : 2023-06-29 Huanhuan Gao, Yiqiong Liu, Ziwei Shi, Hongliang Zhang, Mengyang Wang, Huating Chen, Yan Li, Shaifei Ji, Jiangbing Xiang, Wei Pi, Laixian Zhou, Yiyue Hong, Lu Wu, Aizhen Cai, Xiaobing Fu, Xiaoyan Sun
Background Promoting rapid wound healing with functional recovery of all skin appendages is the main goal of regenerative medicine. So far current methodologies, including the commonly used back excisional wound model (BEWM) and paw skin scald wound model, are focused on assessing the regeneration of either hair follicles (HFs) or sweat glands (SwGs). How to achieve de novo appendage regeneration by
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Notch4 participates in mesenchymal stem cell-induced differentiation in 3D-printed matrix and is implicated in eccrine sweat gland morphogenesis Burns Trauma (IF 5.3) Pub Date : 2023-06-29 Yuzhen Wang, Fanliang Zhang, Bin Yao, Linhao Hou, Zhao Li, Wei Song, Yi Kong, Yaxin Tan, Xiaobing Fu, Sha Huang
Background Eccrine sweat gland (SG) plays a crucial role in thermoregulation but exhibits very limited regenerative potential. Although SG lineage-restricted niches dominate SG morphogenesis and benefit SG regeneration, rebuilding niches in vivo is challenging for stem cell therapeutic applications. Hence, we attempted to screen and tune the critical niche-responding genes that dually respond to both
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Postbiotics as potential new therapeutic agents for sepsis Burns Trauma (IF 5.3) Pub Date : 2023-06-16 Xiran Lou, Jinfang Xue, Ruifei Shao, Chunyan Mo, Fuping Wang, Guobing Chen
Sepsis is the main cause of death in critically ill patients and gut microbiota dysbiosis plays a crucial role in sepsis. On the one hand, sepsis leads to the destruction of gut microbiota and induces and aggravates terminal organ dysfunction. On the other hand, the activation of pathogenic gut flora and the reduction in beneficial microbial products increase the susceptibility of the host to sepsis
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Using Zhang’s supertension-relieving suture technique with slowly-absorbable barbed sutures in the management of pathological scars: a multicenter retrospective study Burns Trauma (IF 5.3) Pub Date : 2023-06-16 Peiru Min, Shunuo Zhang, Dorsa Gholamali Sinaki, Ping Yao, Fuhua Hu, Xin Wang, Danya Zhou, Jun Chai, Yixin Zhang
Background An ideal tension-relieving suture should be efficient for >3 months to retrieve normal tensile strength. Most preexisting suturing techniques provided tension elimination followed by relapse and scar proliferation due to absorption and cut-through of the sutures. This study introduces a simple but effective suture technique developed by a senior author (ZYX) to solve this problem. Methods
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Decoding the molecular landscape of keloids: new insights from single-cell transcriptomics Burns Trauma (IF 5.3) Pub Date : 2023-06-09 Yijun Xia, Youbin Wang, Mengjie Shan, Yan Hao, Zhengyun Liang
Keloids are a fibrotic disease caused by an excessive accumulation of extracellular matrix in the dermis; they have neoplasia-like properties of aggressive growth and high posttreatment recurrence rates. Therefore, it is imperative to gain additional insight into the pathobiology of keloid formation. Single-cell RNA sequencing (scRNA-seq) technology has brought data-driven innovation to understanding
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Targeting neuronal mitophagy in ischemic stroke: an update Burns Trauma (IF 5.3) Pub Date : 2023-06-01 Jun Li, Jiaying Wu, Xinyu Zhou, Yangyang Lu, Yuyang Ge, Xiangnan Zhang
Cerebral ischemia is a neurological disorder associated with complex pathological mechanisms, including autophagic degradation of neuronal mitochondria, or termed mitophagy, following ischemic events. Despite being well-documented, the cellular and molecular mechanisms underlying the regulation of neuronal mitophagy remain unknown. So far, the evidence suggests neuronal autophagy and mitophagy are
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Sphingosine-1-phosphate derived from PRP-Exos promotes angiogenesis in diabetic wound healing via the S1PR1/AKT/FN1 signalling pathway Burns Trauma (IF 5.3) Pub Date : 2023-05-25 Tianyi Chen, Peiyang Song, Min He, Shunli Rui, Xiaodong Duan, Yu Ma, David G Armstrong, Wuquan Deng
Background Sphingosine-1-phosphate (S1P), a key regulator of vascular homeostasis and angiogenesis, is enriched in exosomes derived from platelet-rich plasma (PRP-Exos). However, the potential role of PRP-Exos-S1P in diabetic wound healing remains unclear. In this study, we investigated the underlying mechanism of PRP-Exos-S1P in diabetic angiogenesis and wound repair. Methods Exosomes were isolated
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Characterization of cellular senescence in radiation ulcers and therapeutic effects of mesenchymal stem cell-derived conditioned medium. Burns Trauma (IF 5.3) Pub Date : 2023-05-11 Wanchao Chen,Yang Wang,Jiancheng Zheng,Yan Chen,Can Zhang,Wei Yang,Lingling Wu,Zeyu Yang,Yu Wang,Chunmeng Shi
Background Radiation ulcers are a common and severe injury after uncontrolled exposure to ionizing radiation. The most important feature of radiation ulcers is progressive ulceration, which results in the expansion of radiation injury to the nonirradiated area and refractory wounds. Current theories cannot explain the progression of radiation ulcers. Cellular senescence refers to as irreversible growth
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Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease Burns Trauma (IF 5.3) Pub Date : 2023-05-04 Er-jin Wang, Ming-Yue Wu, Zheng-yu Ren, Ying Zheng, Richard D Ye, Chris Soon Heng TAN, Yitao Wang, Jia-Hong Lu
Inflammatory bowel disease (IBD) is a chronic, non-specific, recurrent inflammatory disease, majorly affecting the gastrointestinal tract. Due to its unclear pathogenesis, the current therapeutic strategy for IBD is focused on symptoms alleviation. Autophagy is a lysosome-mediated catabolic process for maintaining cellular homeostasis. Genome-wide association studies and subsequent functional studies
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A single-stage bilayered skin reconstruction using Glyaderm® as an acellular dermal regeneration template results in improved scar quality: an intra-individual randomized controlled trial Burns Trauma (IF 5.3) Pub Date : 2023-05-02 Ignace De Decker, Henk Hoeksema, Jozef Verbelen, Petra De Coninck, Marijn Speeckaert, Sofie De Schepper, Phillip Blondeel, Ali Pirayesh, Stan Monstrey, Karel E Y Claes
Background Absence of almost the entire reticular dermal layer is inherent to the use of autologous split-thickness skin grafting (STSG) to close full-thickness wounds, often resulting in hypertrophic scars and contractures. Many dermal substitutes have been developed, but unfortunately most have varying results in terms of cosmetic and/or functional improvement as well as patient satisfaction, in
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Neural grafts containing exosomes derived from Schwann cell-like cells promote peripheral nerve regeneration in rats Burns Trauma (IF 5.3) Pub Date : 2023-04-28 Taotao Hu, Shusen Chang, Fang Qi, Zhonghui Zhang, Jiayin Chen, Lingli Jiang, Dali Wang, Chengliang Deng, Kaiyu Nie, Guangchao Xu, Zairong Wei
Background Schwann cell-like cells (SCLCs), differentiated from mesenchymal stem cells, have shown promising outcomes in the treatment of peripheral nerve injuries in preclinical studies. However, certain clinical obstacles limit their application. Hence, the primary aim of this study was to investigate the role of exosomes derived from SCLCs (SCLCs-exo) in peripheral nerve regeneration. Methods SCLCs
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MicroRNAs in septic acute kidney injury Burns Trauma (IF 5.3) Pub Date : 2023-03-21 Bo Wang, Jun Xu, Ping Fu, Liang Ma
Sepsis is a potentially fatal complication of burns and trauma that can cause acute kidney injury (AKI) with substantial morbidity and mortality, but this disease is poorly understood. Despite medical advances, effective therapeutic regimens for septic AKI remain uncommon. MicroRNAs (miRNAs) are endogenous non-coding RNAs that influence the translation of target messenger RNAs in a variety of biological
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The application of corticosteroids for pathological scar prevention and treatment: current review and update Burns Trauma (IF 5.3) Pub Date : 2023-03-20 Meiying Sheng, Yunsheng Chen, Hua Li, Yixin Zhang, Zheng Zhang
The prevention and treatment of pathological scars remain challenging. Corticosteroids are the mainstay drugs in clinical scar prevention and treatment as they effectively induce scar regression and improve scar pruritus and pain. Currently, intralesional injections of corticosteroids are widely used in clinical practice. These require professional medical manipulation; however, the significant accompanying
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Current understanding of the chronic stress response to burn injury from human studies Burns Trauma (IF 5.3) Pub Date : 2023-03-14 Tyler Osborne, Bradley Wall, Dale W Edgar, Timothy Fairchild, Fiona Wood
There is a marked inflammatory and hypermetabolic response following a burn injury. The interlinked responses are more pronounced than for other forms of trauma and can persist for ≥3 years post-injury in burned patients. After a burn, patients have an increased risk of diseases of ageing including cancer, diabetes and cardiovascular disease, highlighting the need for effective long-term strategies
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Efficacy and safety of extracorporeal membrane oxygenation for burn patients: a comprehensive systematic review and meta-analysis. Burns Trauma (IF 5.3) Pub Date : 2023-03-01 Xue Heng,Peng Cai,Zhiqiang Yuan,Yizhi Peng,Gaoxing Luo,Haisheng Li
Background Respiratory and circulatory dysfunction are common complications and the leading causes of death among burn patients, especially in severe burns and inhalation injury. Recently, extracorporeal membrane oxygenation (ECMO) has been increasingly applied in burn patients. However, current clinical evidence is weak and conflicting. This study aimed to comprehensively evaluate the efficacy and
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Myocardial injury: where inflammation and autophagy meet. Burns Trauma (IF 5.3) Pub Date : 2023-03-01 Chunping Liu,Yanjiao Liu,Huiqi Chen,Xiaofei Yang,Chuanjian Lu,Lei Wang,Jiahong Lu
Autophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles, aged proteins and intracellular contents to maintain the homeostasis of the intracellular microenvironment. Activation of autophagy can be observed during myocardial injury, during which inflammatory responses are strongly triggered. Autophagy can inhibit the inflammatory response and regulate the inflammatory
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Adjusting the stiffness of a cell-free hydrogel system based on tissue-specific extracellular matrix to optimize adipose tissue regeneration. Burns Trauma (IF 5.3) Pub Date : 2023-03-01 Ye Li,Xin Bi,Mengfan Wu,Xinyao Chen,Weiqing Zhan,Ziqing Dong,Feng Lu
Background Large-area soft tissue defects are challenging to reconstruct. Clinical treatment methods are hampered by problems associated with injury to the donor site and the requirement for multiple surgical procedures. Although the advent of decellularized adipose tissue (DAT) offers a new solution to these problems, optimal tissue regeneration efficiency cannot be achieved because the stiffness
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Nuclear fragile X mental retardation-interacting protein 1-mediated ribophagy protects T lymphocytes against apoptosis in sepsis. Burns Trauma (IF 5.3) Pub Date : 2023-02-28 Peng-Yue Zhao,Ren-Qi Yao,Li-Yu Zheng,Yao Wu,Yu-Xuan Li,Ning Dong,Jing-Yan Li,Xiao-Hui Du,Yong-Ming Yao
Background Ribophagy is a selective autophagic process that specifically degrades dysfunctional or superfluous ribosomes to maintain cellular homeostasis. Whether ribophagy can ameliorate the immunosuppression in sepsis similar to endoplasmic reticulum autophagy (ERphagy) and mitophagy remains unclear. This study was conducted to investigate the activity and regulation of ribophagy in sepsis and to
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Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications. Burns Trauma (IF 5.3) Pub Date : 2023-02-28 Yan Jin,Yixing Song,Jiaqi Lin,Tianqing Liu,Guicai Li,Biqin Lai,Yun Gu,Gang Chen,Lingyan Xing
Spinal cord injury (SCI) is an incurable trauma that frequently results in partial or complete loss of motor and sensory function. Massive neurons are damaged after the initial mechanical insult. Secondary injuries, which are triggered by immunological and inflammatory responses, also result in neuronal loss and axon retraction. This results in defects in the neural circuit and a deficiency in the
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Melatonin influences the biological characteristics of keloid fibroblasts through the Erk and Smad signalling pathways Burns Trauma (IF 5.3) Pub Date : 2023-02-27 Shaobin Huang, Wuguo Deng, Yunxian Dong, Zhicheng Hu, Yi Zhang, Peng Wang, Xiaoling Cao, Miao Chen, Pu Cheng, Hailin Xu, Wenkai Zhu, Bing Tang, Jiayuan Zhu
Background Keloids are abnormal fibrous hyperplasias that are difficult to treat. Melatonin can be used to inhibit the development of certain fibrotic diseases but has never been used to treat keloids. We aimed to discover the effects and mechanisms of melatonin in keloid fibroblasts (KFs). Methods Flow cytometry, CCK-8 assays, western blotting, wound-healing assays, transwell assays, collagen gel