当前期刊: Thorax Go to current issue    加入关注   
显示样式:        排序: 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Highlights from this issue
    Thorax (IF 9.640) Pub Date : 2020-04-01
    The Triumvirate

    This month’s Airwaves takes its cue from the “Good Vibrations” editorial on page 296 , to bring you a musically themed Airwaves. Our editorial highlights with segue effortlessly from respiratory medicine to the “Rock and Roll” Hall of Fame and back again… When it was released in 1966, this three and a half minute track by the Beach Boys was the costliest single ever recorded and was more than 6 months

    更新日期:2020-03-28
  • ‘Good vibrations’: positional treatments for obstructive sleep apnoea
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Raphael Heinzer

    Obstructive sleep apnoea (OSA) is at least twice more severe in the supine position compared with the non-supine positions in about three quarters of patients with OSA.1 About one-third of them even have ‘exclusively positional’ sleep apnoea with normal apnoea–hypopnoea index (AHI) in the non-supine positions, which makes them accessible to positional treatment (PT). Until recently, most PT devices

    更新日期:2020-03-28
  • Smoking ban in cars protects children, but is vaping ‘The Elephant in the Car’?
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Christabella Ng; Alan Robert Smyth

    In March 2006, smoking in public places was banned in Scotland. The following year a similar ban was introduced in England—the last of the UK home nations to adopt this policy. At the time, some suggested that the ban might paradoxically increase children’s exposure to environmental tobacco smoke (ETS) in the home. Parents who were unable to smoke in public places, such as pubs or restaurants, might

    更新日期:2020-03-28
  • Prospective community programme versus parent-driven care to prevent respiratory morbidity in children following hospitalisation with severe bronchiolitis or pneumonia.
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Catherine Ann Byrnes,Adrian Trenholme,Shirley Lawrence,Harley Aish,Julie Anne Higham,Karen Hoare,Aileen Elborough,Charissa McBride,Lyndsay Le Comte,Christine McIntosh,Florina Chan Mow,Mirjana Jaksic,Russell Metcalfe,Christin Coomarasamy,William Leung,Alison Vogel,Teuila Percival,Henare Mason,Joanna Stewart

    BACKGROUND Hospitalisation with severe lower respiratory tract infection (LRTI) in early childhood is associated with ongoing respiratory symptoms and possible later development of bronchiectasis. We aimed to reduce this intermediate respiratory morbidity with a community intervention programme at time of discharge. METHODS This randomised, controlled, single-blind trial enrolled children aged <2 years

    更新日期:2020-03-28
  • External validation of a convolutional neural network artificial intelligence tool to predict malignancy in pulmonary nodules
    Thorax (IF 9.640) Pub Date : 2020-04-01
    David R Baldwin; Jennifer Gustafson; Lyndsey Pickup; Carlos Arteta; Petr Novotny; Jerome Declerck; Timor Kadir; Catarina Figueiras; Albert Sterba; Alan Exell; Vaclav Potesil; Paul Holland; Hazel Spence; Alison Clubley; Emma O'Dowd; Matthew Clark; Victoria Ashford-Turner; Matthew EJ Callister; Fergus V Gleeson

    Background Estimation of the risk of malignancy in pulmonary nodules detected by CT is central in clinical management. The use of artificial intelligence (AI) offers an opportunity to improve risk prediction. Here we compare the performance of an AI algorithm, the lung cancer prediction convolutional neural network (LCP-CNN), with that of the Brock University model, recommended in UK guidelines. Methods

    更新日期:2020-03-28
  • Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study.
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Gabriela P Peralta,Alessandro Marcon,Anne-Elie Carsin,Michael J Abramson,Simone Accordini,André Fs Amaral,Josep M Antó,Gayan Bowatte,Peter Burney,Angelo Corsico,Pascal Demoly,Shyamali Dharmage,Bertil Forsberg,Elaine Fuertes,Vanessa Garcia-Larsen,Thorarinn Gíslason,José-Antonio Gullón,Joachim Heinrich,Mathias Holm,Deborah L Jarvis,Christer Janson,Rain Jogi,Ane Johannessen,Bénédicte Leynaert,Jesús Martínez-Moratalla

    BACKGROUND Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). METHODS We included 3673 participants recruited at

    更新日期:2020-03-28
  • Activation of complement component 3 is associated with airways disease and pulmonary emphysema in alpha-1 antitrypsin deficiency.
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Michael E O'Brien,Laura Fee,Niall Browne,Tomás P Carroll,Paula Meleady,Michael Henry,Karen McQuillan,Mark P Murphy,Mark Logan,Cormac McCarthy,Oliver J McElvaney,Emer P Reeves,Noel G McElvaney

    INTRODUCTION Alpha-1 antitrypsin (AAT) deficiency (AATD) is associated with early onset emphysema. The aim of this study was to investigate whether AAT binding to plasma constituents could regulate their activation, and in AATD, exploit this binding event to better understand the condition and uncover novel biomarkers of therapeutic efficacy. METHODS To isolate AAT linker proteins, plasma samples were

    更新日期:2020-03-28
  • Comparing treatment effects of a convenient vibratory positional device to CPAP in positional OSA: a crossover randomised controlled trial.
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Yingjuan Mok,Alvin Tan,Pon Poh Hsu,Audrey Seow,Yiong Huak Chan,Hang Siang Wong,Yvonne Poh,Keith K H Wong

    OBJECTIVES Up to 77% of patients with obstructive sleep apnoea (OSA) have positional OSA (POSA) but traditional positional therapy (PT) methods have failed as they were poorly tolerated. New convenient vibratory PT devices have been invented but while recent studies suggest high treatment efficacy and adherence, there are no published data comparing these devices directly with continuous positive airway

    更新日期:2020-03-28
  • Sputum microbiome profiling in COPD: beyond singular pathogen detection.
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Benedikt Ditz,Stephanie Christenson,John Rossen,Chris Brightling,Huib A M Kerstjens,Maarten van den Berge,Alen Faiz

    Culture-independent microbial sequencing techniques have revealed that the respiratory tract harbours a complex microbiome not detectable by conventional culturing methods. The contribution of the microbiome to chronic obstructive pulmonary disease (COPD) pathobiology and the potential for microbiome-based clinical biomarkers in COPD are still in the early phases of investigation. Sputum is an easily

    更新日期:2020-03-28
  • Impact of banning smoking in cars with children on exposure to second-hand smoke: a natural experiment in England and Scotland.
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Anthony A Laverty,Thomas Hone,Eszter P Vamos,Philip E Anyanwu,David Taylor-Robinson,Frank de Vocht,Christopher Millett,Nicholas S Hopkinson

    England banned smoking in cars carrying children in 2015 and Scotland in 2016. We used survey data from 3 years for both countries (NEngland=3483-6920, NScotland=232-319) to assess effects of the English ban using logistic regression within a difference-in-differences framework. Among children aged 13-15 years, self-reported levels of regular exposure to smoke in cars for Scotland were 3.4% in 2012

    更新日期:2020-03-28
  • Implementation of targeted screening for lung cancer in a high-risk population within routine NHS practice using low-dose computed tomography.
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Helen Grover,Thomas Ross,Elizabeth Fuller

    We report a primary care-based lung cancer targeted screening programme using low-dose CT (LDCT) in South Tyneside and Sunderland. Ever smokers with ≥10 pack-years aged 55-74 years were identified at annual COPD review. 925 individuals attended for LDCT. 2% (n=19/925) had lung cancer diagnosed. 66.7% (n=14/21) had early stage disease and 78.9% (n=15/19) were offered treatment with curative intent.

    更新日期:2020-03-28
  • COPD clinical control as a predictor of future exacerbations: concept validation in the SPARK study population.
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Miriam Barrecheguren,Konstantinos Kostikas,Karen Mezzi,Steven Shen,Bernardino Alcazar,Juan José Soler-Cataluña,Marc Miravitlles,Jadwiga A Wedzicha

    The concept of chronic obstructive pulmonary disease (COPD) control has been proposed to guide treatment decisions in COPD. In this study, we aimed to validate the prospective value of this concept in the SPARK study population. Control was assessed based on COPD stability and impact. Patients with low impact and stability during weeks 1-12 were classified as controlled, and exacerbations were measured

    更新日期:2020-03-28
  • Going with the flow: diagnosing a lymphocyte-rich pleural effusion.
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Catherine Hyams,Megan H Jenkins,Richard Daly,Izak C Heys,Nicholas A Maskell

    ### Presentation to pleural clinic A 52-year-old Medical Secretary was seen in Pleural Outpatient Clinic as follow-up after hospital discharge from the Surgical team 3 weeks previously. Since discharge, the patient had progressive breathlessness with an exercise tolerance of 10 m (previously unlimited) and noted a mild dry cough. She was a lifelong non-smoker. Fevers, sweats or weight loss were not

    更新日期:2020-03-28
  • Just because it walks like a duck, quacks like a duck, doesn't mean it can't be a goose!
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Nicolas Piliero,Adrien Jankowski,Frédéric Thony,Bruno Degano,Hélène Bouvaist

    The echocardiogram of a 62-year-old woman with a medical history of anti-synthetase syndrome associated with interstitial lung disease (ILD) suggested pulmonary hypertension. An etiological evaluation of pulmonary hypertension was performed. The ventilation/perfusion scan had the aspect of perfusion defects with dissociation. The CT scan showed features of active ILD (basal and subpleural pulmonary

    更新日期:2020-03-28
  • Rapid development of bullous lung disease: a complication of electronic cigarette use.
    Thorax (IF 9.640) Pub Date : 2020-04-01
    Saminder Singh Kalra,Faye Pais,Eloise Harman,Daniel Urbine

    Electronic cigarettes (EC) use can result in acute lung injury with varying severity of the hypoxic respiratory failure. Spontaneous resolution can result with the cessation of EC use, although some patients with severe disease have required mechanical ventilation. We describe a previously healthy patient who presented with severe hypoxemic respiratory failure and developed a rapidly progressive bullous

    更新日期:2020-03-28
  • Journal club
    Thorax (IF 9.640) Pub Date : 2020-04-01
    David J F Smith

    For cystic fibrosis (CF) patients homozygous for the F508del mutation of the transmembrane conductance regulator (CFTR) protein, a combination of a CFTR potentiator and a corrector has been shown to be beneficial. This pharmaceutical funded double-blinded randomised control trial (Heijerman et al , Lancet 2019;394:1940) examined the clinical outcomes with the addition of elexacaftor (a further corrector)

    更新日期:2020-03-28
  • Duration of neonatal oxygen supplementation, erythropoiesis and blood pressure in young adults born preterm
    Thorax (IF 9.640) Pub Date : 2020-03-26
    Adrien Flahault; Camille Girard-Bock; Rafael Oliveira Fernandes; Anik Cloutier; Yves D Pastore; Thuy Mai Luu; Anne Monique Nuyt

    Background Although erythropoiesis is impaired and anaemia frequent in neonates born preterm, haematopoiesis in adults born preterm has not been previously studied. Objective We, thus, aimed to evaluate haemoglobin and erythropoietin levels in young adults born preterm, to identify neonatal events associated with erythropoiesis in adulthood and to examine the relationships of haemoglobin levels with

    更新日期:2020-03-27
  • Energy conservation technique improves dyspnoea when patients with severe COPD climb stairs: a randomised crossover study
    Thorax (IF 9.640) Pub Date : 2020-03-26
    Guillaume Prieur; Yann Combret; Clement Medrinal; Nathalie Arnol; Tristan Bonnevie; Francis-Edouard Gravier; Jean Quieffin; Bouchra Lamia; Gregory Reychler; Jean-Christian Borel

    In this randomised, crossover trial, 22 patients with severe chronic obstructive pulmonary disease climbed six flights of stairs (108 steps) twice, under two test conditions: (1) energy conservation technique (ECT): participants were asked to rest for at least 5 seconds every three steps and (2) control condition: participants climbed the stairs at their own pace. Significant lower dyspnoea (primary

    更新日期:2020-03-27
  • Positive airway pressure in obesity hypoventilation syndrome: is it worth it?
    Thorax (IF 9.640) Pub Date : 2020-03-26
    Amanda Piper; Jean Louis Pépin; Nicholas Hart

    Over the past decade, increasing attention has been paid to the evaluation and management of obesity hypoventilation syndrome (OHS).1 This disorder is characterised by daytime hypercapnia and three main phenotypes of sleep disordered breathing, including severe obstructive sleep apnoea (OSA), combined OSA and OHS and isolated OHS.2 Rising rates of global obesity along with a greater awareness of the

    更新日期:2020-03-27
  • Investigation of a unilateral pleural effusion: What CT scan coverage is optimal?
    Thorax (IF 9.640) Pub Date : 2020-03-26
    Tom Syer; David T Arnold; Sonia Patole; John Harvey; Andrew Medford; Nicholas A Maskell; Anthony Edey

    The use of thoracic CT for patients presenting with a unilateral pleural effusion is well established. However, there is no consensus with regard to the inclusion of the entire abdomen and pelvis in the initial imaging protocol. In this prospective UK-based study, 249 patients presenting with a unilateral effusion had a CT thorax/abdomen/pelvis performed. The prevalence of malignancy on thoracic CT

    更新日期:2020-03-27
  • Cost-effectiveness of positive airway pressure modalities in obesity hypoventilation syndrome with severe obstructive sleep apnoea
    Thorax (IF 9.640) Pub Date : 2020-03-26
    Juan F Masa; Babak Mokhlesi; Iván Benítez; Francisco Javier Gómez de Terreros Caro; M-Ángeles Sánchez-Quiroga; Auxiliadora Romero; Candela Caballero; Maria Luz Alonso-Álvarez; Estrella Ordax-Carbajo; Teresa Gómez-García; Mónica González; Soledad López-Martín; Jose M Marin; Sergi Martí; Trinidad Díaz-Cambriles; Eusebi Chiner; Carlos Egea; Javier Barca; Francisco-José Vázquez-Polo; Miguel Angel Negrín;

    Background Obesity hypoventilation syndrome (OHS) is treated with either non-invasive ventilation (NIV) or CPAP, but there are no long-term cost-effectiveness studies comparing the two treatment modalities. Objectives We performed a large, multicentre, randomised, open-label controlled study to determine the comparative long-term cost and effectiveness of NIV versus CPAP in patients with OHS with severe

    更新日期:2020-03-27
  • Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits
    Thorax (IF 9.640) Pub Date : 2020-03-26
    Alexander G Mathioudakis; Wim Janssens; Pradeesh Sivapalan; Aran Singanayagam; Mark T Dransfield; Jens-Ulrik Stæhr Jensen; Jørgen Vestbo

    Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically

    更新日期:2020-03-27
  • Correction: Percent low attenuation volume and fractal dimension of low attenuation clusters on computed tomography predict different long-term outcomes in COPD
    Thorax (IF 9.640) Pub Date : 2020-03-24
    BMJ Publishing Group Ltd and British Thoracic Society

    Shimizu K, Tanabe N, Tho NV, et al . Percent low attenuation volume and fractal …

    更新日期:2020-03-24
  • Is childhood obstructive sleep apnoea an independent risk factor of hypertension in adulthood?
    Thorax (IF 9.640) Pub Date : 2020-03-24
    Rosemary S C Horne; Montida Veeravigrom

    Over a third of children snore when they are asleep and until the last decade this has been considered benign by both parents and health professionals. Snoring was considered something that children would simply grow out of. Snoring is the hallmark symptom of sleep-disordered breathing (SDB), which ranges in severity from simple or primary snoring to obstructive sleep apnoea (OSA) which affects up

    更新日期:2020-03-24
  • Childhood OSA is an independent determinant of blood pressure in adulthood: longitudinal follow-up study
    Thorax (IF 9.640) Pub Date : 2020-03-24
    Kate Ching-ching Chan; Chun Ting Au; Lai Ling Hui; Yun Kwok Wing; Albert Martin Li

    Background Current literature supports cross-sectional association between childhood obstructive sleep apnoea (OSA) and elevated blood pressure (BP). However, long-term cardiovascular outcomes in children with OSA remain unexplored. Objective To evaluate the associations of childhood OSA with BP parameters in a prospective 10 year follow-up study. Methods Participants were recruited from a cohort established

    更新日期:2020-03-24
  • Correction: British thoracic society winter meeting 2019
    Thorax (IF 9.640) Pub Date : 2020-03-23
    BMJ Publishing Group Ltd and British Thoracic Society

    British Thoracic Society Winter Meeting 2019. Thorax 2019;74(Suppl 2):A1–A249. https://thorax.bmj.com/content/74/Suppl_2 Since initial publication of these abstracts there are some changes and additions required as follows: 10.1136/thorax-2019-BTSabstracts2019.46 Abstract withdrawn — not presented at the meeting 10.1136/thorax-2019-BTSabstracts2019.213 Abstract withdrawn — not presented at the meeting

    更新日期:2020-03-24
  • Identification of eight-protein biosignature for diagnosis of tuberculosis
    Thorax (IF 9.640) Pub Date : 2020-03-22
    Qianting Yang; Qi Chen; Mingxia Zhang; Yi Cai; Fan Yang; Jieyun Zhang; Guofang Deng; Taosheng Ye; Qunyi Deng; Guobao Li; Huihua Zhang; Yuhua Yi; Ruo-Pan Huang; Xinchun Chen

    Background Biomarker-based tests for diagnosing TB currently rely on detecting Mycobacterium tuberculosis (Mtb) antigen-specific cellular responses. While this approach can detect Mtb infection, it is not efficient in diagnosing TB, especially for patients who lack aetiological evidence of the disease. Methods We prospectively enrolled three cohorts for our study for a total of 630 subjects, including

    更新日期:2020-03-22
  • FLCN-regulated miRNAs suppressed reparative response in cells and pulmonary lesions of Birt-Hogg-Dubé syndrome
    Thorax (IF 9.640) Pub Date : 2020-03-17
    Haiyan Min; Dehua Ma; Wei Zou; Yongzheng Wu; Yibing Ding; Chengchu Zhu; Anqi Lin; Shiyu Song; Qiao Liang; Baofu Chen; Bin Zhang; Yueming Wan; Minhua Ye; Yanqing Pan; Yanting Wen; long Yi; Qian Gao

    Background Birt-Hogg-Dubé Syndrome (BHDS) characterised by skin fibrofolliculomas, kidney tumour and pulmonary cysts/pneumothorax is caused by folliculin (FLCN) germline mutations. The pathology of both neoplasia and focused tissue loss of BHDS strongly features tissue-specific behaviour of the gene. Isolated cysts/pneumothorax is the most frequent atypical presentation of BHDS and often misdiagnosed

    更新日期:2020-03-19
  • Four thoracic cavity compartments caused by bilateral bifid intrathoracic rib
    Thorax (IF 9.640) Pub Date : 2020-03-13
    Xuhong Xue; Sheng Zhao

    A 13-year-old boy who had hump-back was taken to the hospital. The whole spine posteroanterior and lateral radiograph showed failures of segmentation from T5 to T8 vertebra, as well as laminae fusion, diagnosed congenital thoracic kyphoscoliosis. Spinal fusion surgery was suggested because of the potential progress of segmental kyphosis. However, unusual imaging revealed that four thoracic cavity compartments

    更新日期:2020-03-16
  • Tracheal squamous cell papilloma with an aberrant artery in the stalk
    Thorax (IF 9.640) Pub Date : 2020-03-13
    Yahua Li; Kewei Ren; Liqun Ye; Jianzhuang Ren; Xinwei Han

    An 81-year-old woman presented with a 1-year history of chronic cough and progressive breath shortness. Physical examination was notable for wheezing. Her laboratory test results were normal. The chest contrast-enhanced CT scan revealed a cauliflower-like lesion in the upper third dorsolateral trachea, and an artery in the stalk of the tumour was observed (figure 1A,B). Considering the potential of

    更新日期:2020-03-16
  • Novel pleural-bladder pump in malignant pleural effusions: from animal model to man
    Thorax (IF 9.640) Pub Date : 2020-03-12
    Philippe Astoul; Sophie Laroumagne; Jeroen Capel; Nicholas A Maskell

    Malignant pleural effusion is common and causes disabling symptoms such as breathlessness. Treatments are palliative and centred around improving symptoms and quality of life but an optimal management strategy is yet to be universally agreed. A novel pump system, allowing fluid to be moved from the pleural space to the urinary bladder, may have a role for the management of recurrent malignant pleural

    更新日期:2020-03-12
  • Highlights from this issue
    Thorax (IF 9.640) Pub Date : 2020-03-01
    The Triumvirate

    To celebrate the current six nations rugby tournament, this month’s Airwaves draws inspiration from the giants (literally) comprising the national teams of England, Wales, Scotland, Ireland, France and Italy. No matter which team you are rooting for there is something for everyone in this issue! Ireland won the Six Nations Championship in 2018 – a tournament marred by numerous injuries, including back

    更新日期:2020-03-05
  • Mendelian randomisation supports causal link between obesity and asthma.
    Thorax (IF 9.640) Pub Date : 2020-01-08
    Diana A van der Plaat

    Over the last few decades the prevalence of both obesity and asthma has increased substantially in many parts of the world. A clear link between obesity and asthma incidence and severity has been shown in both children and adults in observational studies.1 2 The biological mechanisms underlying this relationship are not fully understood. Hypotheses to explain the association include mechanisms related

    更新日期:2020-03-05
  • No place like home: initiation of non-invasive ventilation for stable severe COPD.
    Thorax (IF 9.640) Pub Date : 2020-01-29
    Nicholas S Hill

    For nearly 60 years, clinicians and investigators have explored the possibility that non-invasive ventilatory assistance might improve the function of patients with stable severe chronic obstructive pulmonary disease (COPD).1 Early studies used negative pressure ventilators with the idea that the rest of the respiratory muscles would make them stronger, but these were poorly tolerated.2 For the past

    更新日期:2020-03-05
  • Great debate: surgery versus stereotactic radiotherapy for early-stage non-small cell lung cancer.
    Thorax (IF 9.640) Pub Date : 2020-01-21
    Crispin Hiley,Ahmed Salem,Tim Batchelor,Fiona McDonald,Matthew Evison

    Stereotactic ablative radiotherapy (SABR) for primary early-stage non-small cell lung cancer (NSCLC) is a precision therapy given over three to eight fractions, delivering a high dose to the tumour while minimising the dose to surrounding non-malignant tissues. SABR offers several advantages over conventionally fractionated radiotherapy, which is given daily for 4.0–6.5 weeks. Importantly, due to improved

    更新日期:2020-03-05
  • Is the microbiome-induced glycolytic pathway a harbinger of acute exacerbation of idiopathic pulmonary fibrosis?
    Thorax (IF 9.640) Pub Date : 2020-01-23
    Ram P Naikawadi

    Idiopathic pulmonary fibrosis (IPF) is a chronic age-related disease with increasing prevalence that is characterised by progressive loss of lung function, which contributes to accelerated morbidity and mortality. While the exact aetiology is unknown, studies in patients with IPF and murine models of lung fibrosis have established genetic mutations1 2 and telomere dysfunction in alveolar epithelial

    更新日期:2020-03-05
  • Adiposity and asthma in adults: a bidirectional Mendelian randomisation analysis of The HUNT Study
    Thorax (IF 9.640) Pub Date : 2020-03-01
    Yi-Qian Sun; Ben Michael Brumpton; Arnulf Langhammer; Yue Chen; Kirsti Kvaløy; Xiao-Mei Mai

    Background We aimed to investigate the potential causal associations of adiposity with asthma overall, asthma by atopic status or by levels of symptom control in a large adult population and stratified by sex. We also investigated the potential for reverse causation between asthma and risk of adiposity. Methods We performed a bidirectional one-sample Mendelian randomisation (MR) study using the Norwegian

    更新日期:2020-03-05
  • RAGE-induced ILC2 expansion in acute lung injury due to haemorrhagic shock.
    Thorax (IF 9.640) Pub Date : 2020-01-14
    Kai Zhang,Yue Jin,Dengming Lai,Jieyan Wang,Yang Wang,Xiaoliang Wu,Melanie Scott,Yuehua Li,Jinchao Hou,Timothy Billiar,Mark Wilson,Qiang Shu,Xiangming Fang,Jie Fan

    BACKGROUND Type 2 immune dysfunction contributes to acute lung injury and lethality following haemorrhagic shock (HS) and trauma. Group 2 innate lymphoid cells (ILC2s) play a significant role in the regulation of type 2 immune responses. However, the role of ILC2 in post-HS acute lung injury and the underlying mechanism has not yet been elucidated. OBJECTIVE To investigate the regulatory role of ILC2s

    更新日期:2020-03-05
  • Non-communicable respiratory disease and air pollution exposure in Malawi: a prospective cohort study.
    Thorax (IF 9.640) Pub Date : 2020-02-20
    Sarah Rylance,Chris Jewell,Andrew Naunje,Frank Mbalume,John D Chetwood,Rebecca Nightingale,Lindsay Zurba,Graham Flitz,Stephen B Gordon,Maia Lesosky,John R Balmes,Kevin Mortimer

    RATIONALE There are no population-based studies from sub-Saharan Africa describing longitudinal lung function in adults. OBJECTIVES To explore the lung function trajectories and their determinants, including the effects of air pollution exposures and the cleaner-burning biomass-fuelled cookstove intervention of the Cooking and Pneumonia Study (CAPS), in adults living in rural Malawi. METHODS We assessed

    更新日期:2020-03-05
  • GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation.
    Thorax (IF 9.640) Pub Date : 2019-12-10
    Soo Jung Cho,Jong-Seok Moon,Kiichi Nikahira,Ha Seon Yun,Rebecca Harris,Kyung Sook Hong,Huarong Huang,Augustine M K Choi,Heather Stout-Delgado

    BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a rapidly progressive, fatal lung disease that affects older adults. One of the detrimental natural histories of IPF is acute exacerbation of IPF (AE-IPF), of which bacterial infection is reported to play an important role. However, the mechanism by which bacterial infection modulates the fibrotic response remains unclear. OBJECTIVES Altered glucose

    更新日期:2020-03-05
  • Post-treatment survival difference between lobectomy and stereotactic ablative radiotherapy in stage I non-small cell lung cancer in England.
    Thorax (IF 9.640) Pub Date : 2019-12-26
    Aamir Khakwani,Susan Harden,Paul Beckett,David Baldwin,Neal Navani,Doug West,Richard Hubbard

    BACKGROUND Approximately 15%-20% of all non-small cell lung cancer (NSCLC) cases present with stage I disease. Surgical resection traditionally offers the best chance of a cure but some patients will not have this treatment due to older age, comorbidities or personal choice. Stereotactic ablative radiotherapy (SABR) has become an established curative intent treatment option for patients who are not

    更新日期:2020-03-05
  • Home initiation of chronic non-invasive ventilation in COPD patients with chronic hypercapnic respiratory failure: a randomised controlled trial
    Thorax (IF 9.640) Pub Date : 2020-03-01
    Marieke L Duiverman; Judith M Vonk; Gerrie Bladder; Joost P van Melle; Jellie Nieuwenhuis; Anda Hazenberg; Huib A M Kerstjens; Job F M van Boven; Peter J Wijkstra

    Introduction Chronic non-invasive ventilation (NIV) has become evidence-based care for stable hypercapnic COPD patients. While the number of patients increases, home initiation of NIV would greatly alleviate the healthcare burden. We hypothesise that home initiation of NIV with the use of telemedicine in stable hypercapnic COPD is non-inferior to in-hospital NIV initiation. Methods Sixty-seven stable

    更新日期:2020-03-05
  • Zinc supplementation ameliorates lung injury by reducing neutrophil recruitment and activity.
    Thorax (IF 9.640) Pub Date : 2020-01-08
    Inga Wessels,Johanna Theresa Pupke,Klaus-Thilo von Trotha,Alexander Gombert,Anika Himmelsbach,Henrike Josephine Fischer,Michael J Jacobs,Lothar Rink,Jochen Grommes

    INTRODUCTION Zinc is well known for its anti-inflammatory effects, including regulation of migration and activity of polymorphonuclear neutrophils (PMN). Zinc deficiency is associated with inflammatory diseases such as acute lung injury (ALI). As deregulated neutrophil recruitment and their hyper-activation are hallmarks of ALI, benefits of zinc supplementation on the development of lipopolysaccharides

    更新日期:2020-03-05
  • Geospatial and seasonal variation of bronchiolitis in England: a cohort study using hospital episode statistics.
    Thorax (IF 9.640) Pub Date : 2020-01-20
    Kate Marie Lewis,Bianca De Stavola,Pia Hardelid

    BACKGROUND Rates of hospital admissions for bronchiolitis vary seasonally and geographically across England; however, seasonal differences by area remain unexplored. We sought to describe spatial variation in the seasonality of hospital admissions for bronchiolitis and its association with local demographic characteristics. METHODS Singleton children born in English National Health Service hospitals

    更新日期:2020-03-05
  • Patient outcomes associated with post-tuberculosis lung damage in Malawi: a prospective cohort study.
    Thorax (IF 9.640) Pub Date : 2020-02-26
    Jamilah Meghji,Maia Lesosky,Elizabeth Joekes,Peter Banda,Jamie Rylance,Stephen Gordon,Joseph Jacob,Harmien Zonderland,Peter MacPherson,Elizabeth L Corbett,Kevin Mortimer,Stephen Bertel Squire

    BACKGROUND Post-tuberculosis lung damage (PTLD) is a recognised consequence of pulmonary TB (pTB). However, little is known about its prevalence, patterns and associated outcomes, especially in sub-Saharan Africa and HIV-positive adults. METHODS Adult (≥15 years) survivors of a first episode of pTB in Blantyre, Malawi, completed the St George's Respiratory Questionnaire, 6-minute walk test, spirometry

    更新日期:2020-03-05
  • Impact of respiratory muscle training on respiratory muscle strength, respiratory function and quality of life in individuals with tetraplegia: a randomised clinical trial.
    Thorax (IF 9.640) Pub Date : 2020-01-14
    Claire L Boswell-Ruys,Chaminda R H Lewis,Nirupama S Wijeysuriya,Rachel A McBain,Bonsan Bonne Lee,David K McKenzie,Simon C Gandevia,Jane E Butler

    BACKGROUND Respiratory complications remain a leading cause of morbidity and mortality in people with acute and chronic tetraplegia. Respiratory muscle weakness following spinal cord injury-induced tetraplegia impairs lung function and the ability to cough. In particular, inspiratory muscle strength has been identified as the best predictor of the likelihood of developing pneumonia in individuals with

    更新日期:2020-03-05
  • Unusual case of preoperative hypoxaemia.
    Thorax (IF 9.640) Pub Date : 2020-01-06
    Padraic C Ridge,Sarah Cullivan,Christina D Campbell,Anthony O'Regan,Robert M Rutherford

    An 82-year-old woman was admitted electively for surgical stabilisation of a persistently painful osteoporotic fracture of T12 vertebra She had a history of kyphosis with two previous osteoporotic fractures at T8 and T9 treated by kyphoplasty. She was noted to be persistently hypoxic with saturations of 80% on room air. She required 4 L/min of oxygen to maintain her saturations at >94%. There was no

    更新日期:2020-03-05
  • Tuberculosis-induced cartilage fractures leading to collapse of the left main stem bronchus.
    Thorax (IF 9.640) Pub Date : 2020-02-13
    Vanina Livi,Marco Ferrari,Daniela Paioli,Filippo Natali,Rocco Trisolini

    A 94-year-old female patient was referred to the emergency department of our hospital for cough productive of purulent sputum and recurrent episodes of haemoptysis. She was a mild, former smoker. Her medical history was notable for a left-sided pleuropulmonary infection treated for months with antibiotics at the age of 2 years, and for recurrent respiratory infections occurring ever since. Chest CT

    更新日期:2020-03-05
  • Journal club
    Thorax (IF 9.640) Pub Date : 2020-03-01
    Alex Phillips

    Intensive care unit (ICU) acquired weakness (AW) and diaphragm dysfunction (DD) contribute to morbidity and mortality in critically ill patients. Dres et al (Critical Care 2019;23:370) set out to identify risk factors and evaluate the relative impact on weaning and mortality of ICU-AW and ICU-DD. Posthoc analysis was performed on 2 merged cohorts, with 116 patients included. DD was assessed by twitch

    更新日期:2020-03-05
  • Inhalers: to switch or not to switch? That is the question.
    Thorax (IF 9.640) Pub Date : 2019-12-26
    Anna Claire Murphy

    We know that there is an increasing prevalence of asthma and COPD worldwide, leading to increased inhaler use. Chapter 3 of the British National Formulary1 has grown significantly over the years in terms of the number of inhaler options. There are currently, in the UK, more than 20 different inhaler devices available, with over 118 possible combinations of drug and device to prescribe. The inhaler

    更新日期:2020-03-05
  • Treating tuberculosis in low-resource settings: practice pragmatically
    Thorax (IF 9.640) Pub Date : 2020-03-05
    Xiaohui Sun; Najib M Rahman; Abdel Douiri

    Tuberculosis (TB) remains a long-standing life-threatening contagious disease and claimed approximately 1.5 million lives worldwide in 2018. Regional variations occur extensively with polarised incidence rates between low and high TB burden countries.1 TB is a social disease in partnership with poverty. TB burden fluctuates with the rises and falls of socioeconomic development despite the advancements

    更新日期:2020-03-05
  • Green respiratory healthcare: need for proportionality
    Thorax (IF 9.640) Pub Date : 2020-02-24
    Martyn R Partridge

    The Montreal Protocol on Substances That Deplete the Ozone Layer was an example of an amazing international collaboration that has already led to improvements in the ozone layer, although the full effects will not be seen for decades. As part of the process, large numbers of medical aerosols were reformulated such that chlorofluorocarbons were replaced as propellants in pressurised metered dose inhalers

    更新日期:2020-02-24
  • Patient gender bias on the diagnosis of idiopathic pulmonary fibrosis.
    Thorax (IF 9.640) Pub Date : 2020-02-13
    Deborah Assayag,Julie Morisset,Kerri A Johannson,Athol U Wells,Simon L F Walsh

    BACKGROUND Patient sex has clinical and prognostic implications in idiopathic pulmonary fibrosis (IPF). It is not known if sex-related and gender-related discrepancies exist when establishing a diagnosis of IPF. The aim was to determine how patient gender influences the diagnosis of IPF and the physician's diagnostic confidence. METHODS This study was performed using clinical cases compiled from a

    更新日期:2020-02-13
  • Highlights from this issue
    Thorax (IF 9.640) Pub Date : 2020-02-01
    The Triumvirate

    With the release of the twenty fifth James Bond movie early next month, “ No time to die ,” this month’s Airwaves will whet your appetite with a Bond flavoured selection from Thorax. At the beginning of “No time to die,” Bond has left the service and is enjoying some relaxation time. Needless to say the relaxation time is brief and Bond is recruited on a mission to find a missing scientist abducted

    更新日期:2020-01-29
  • Asthma reviews in children: what have we learned?
    Thorax (IF 9.640) Pub Date : 2020-01-02
    Mark L Levy,Louise Fleming

    Asthma is a complex chronic disease, characterised by intermittent respiratory symptoms, airway inflammation and reversible airflow obstruction, without the availability of a single confirmatory diagnostic test. Management of this disease involves many challenges for primary care physicians. These include diagnosis, monitoring, identifying risk and chronic as well as acute management; furthermore,

    更新日期:2020-01-29
  • Looking under the bonnet of bronchopulmonary dysplasia with MRI.
    Thorax (IF 9.640) Pub Date : 2020-02-01
    Andrew Prayle,Tim Rosenow

    Worldwide, 1 in 10 babies are born preterm. Bronchopulmonary dysplasia (BPD, also termed chronic lung disease of prematurity) is the major respiratory complication of preterm birth. The classic Northway description of BPD of airway injury with subsequent inflammation and fibrosis has given way to ‘new BPD’, with less fibrosis, and fewer, larger alveoli. Advances in care (including antenatal steroids

    更新日期:2020-01-29
  • Lung function and asthma control in school-age children managed in UK primary care: a cohort study.
    Thorax (IF 9.640) Pub Date : 2019-10-30
    David Kh Lo,Caroline S Beardsmore,Damian Roland,Mathew Richardson,Yaling Yang,Lesley Danvers,Andrew Wilson,Erol A Gaillard

    BACKGROUND Spirometry and fraction of exhaled nitric oxide (FeNO) are commonly used in specialist centres to monitor children with asthma. The National Institute for Health and Care Excellence recommends spirometry for asthma monitoring from 5 years in all healthcare settings. There is little spirometry and FeNO data in children managed for asthma in UK primary care to support their use. OBJECTIVES

    更新日期:2020-01-29
  • Healthcare system encounters before COPD diagnosis: a registry-based longitudinal cohort study.
    Thorax (IF 9.640) Pub Date : 2019-11-08
    Kate M Johnson,Amir Khakban,Stirling Bryan,Don D Sin,Mohsen Sadatsafavi

    BACKGROUND There is high interest in strategies for improving early detection of chronic obstructive pulmonary disease (COPD). These strategies often rely on opportunistic encounters between patients with undiagnosed COPD and the healthcare system; however, the frequency of these encounters is currently unknown. METHODS We used administrative health data for the province of British Columbia, Canada

    更新日期:2020-01-29
  • Per cent low attenuation volume and fractal dimension of low attenuation clusters on CT predict different long-term outcomes in COPD.
    Thorax (IF 9.640) Pub Date : 2020-01-02
    Kaoruko Shimizu,Naoya Tanabe,Nguyen Van Tho,Masaru Suzuki,Hironi Makita,Susumu Sato,Shigeo Muro,Michiaki Mishima,Toyohiro Hirai,Emiko Ogawa,Yasutaka Nakano,Satoshi Konno,Masaharu Nishimura

    BACKGROUND Fractal dimension (D) characterises the size distribution of low attenuation clusters on CT and assesses the spatial heterogeneity of emphysema that per cent low attenuation volume (%LAV) cannot detect. This study tested the hypothesis that %LAV and D have different roles in predicting decline in FEV1, exacerbation and mortality in patients with COPD. METHODS Chest inspiratory CT scans in

    更新日期:2020-01-29
  • Impact of newborn screening on outcomes and social inequalities in cystic fibrosis: a UK CF registry-based study.
    Thorax (IF 9.640) Pub Date : 2019-11-26
    Daniela K Schlüter,Kevin W Southern,Carol Dryden,Peter Diggle,David Taylor-Robinson

    BACKGROUND Newborn bloodspot screening (NBS) for cystic fibrosis (CF) was introduced across the UK in 2007 but the impact on clinical outcomes and health inequalities for children with CF is unclear. METHODS We undertook longitudinal analyses of UK CF registry data on over 3000 children with CF born between 2000 and 2015. Clinical outcomes were the trajectories of percent predicted forced expiratory

    更新日期:2020-01-29
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
全球疫情及响应:BMC Medicine专题征稿
欢迎探索2019年最具下载量的化学论文
新版X-MOL期刊搜索和高级搜索功能介绍
化学材料学全球高引用
ACS材料视界
南方科技大学
x-mol收录
南方科技大学
自然科研论文编辑服务
上海交通大学彭文杰
中国科学院长春应化所于聪-4-8
武汉工程大学
课题组网站
X-MOL
深圳大学二维材料实验室张晗
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug