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Case of Prenatal Diagnosis of a Fetal Pulmonary Arteriovenous Malformation at Term Diagnostics (IF 3.6) Pub Date : 2024-04-24 Kristina Tchatcheva, Rumen Marinov
In our case, the malformation was diagnosed prenatally at 40 weeks of gestation, and at the age of 14 days, the malformation was removed combined with a segmentectomy of the sixth segment of the left lung. Preoperative diagnostics focus on 3D-CT reconstruction and detailing of the anatomical variations of all arterial and venous vessels, as evident from our case. Treatment includes surgical removal
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Pediatric Crohn’s Disease in the Upper Gastrointestinal Tract: Clinical, Laboratory, Endoscopic, and Histopathological Analysis Diagnostics (IF 3.6) Pub Date : 2024-04-24 Dunja Putniković, Jovan Jevtić, Nina Ristić, Ivan D. Milovanovich, Miloš Đuknić, Milica Radusinović, Nevena Popovac, Irena Đorđić, Zoran Leković, Radmila Janković
Crohn’s disease (CD) is a progressive, multifactorial, immune-mediated disease characterized by chronic inflammation of any part of the gastrointestinal (GI) tract. Pediatric patients present with a more extensive form of the disease, especially in the upper GI tract with various histopathological inflammatory patterns. Our study aims to analyze the clinical, laboratory, endoscopic, and histopathological
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Optical Coherence Tomography in Inherited Macular Dystrophies: A Review Diagnostics (IF 3.6) Pub Date : 2024-04-24 Alba Gómez-Benlloch, Xavier Garrell-Salat, Estefanía Cobos, Elena López, Anna Esteve-Garcia, Sergi Ruiz, Meritxell Vázquez, Laura Sararols, Marc Biarnés
Macular dystrophies (MDs) constitute a collection of hereditary retina disorders leading to notable visual impairment, primarily due to progressive macular atrophy. These conditions are distinguished by bilateral and relatively symmetrical abnormalities in the macula that significantly impair central visual function. Recent strides in fundus imaging, especially optical coherence tomography (OCT), have
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Feasibility of Reduced Iodine Loads for Vascular Assessment Prior to Transcatheter Aortic Valve Implantation (TAVI) Using Spectral Detector CT Diagnostics (IF 3.6) Pub Date : 2024-04-24 Christopher Schuppert, Janek Salatzki, Florian André, Johannes Riffel, David L. Mangold, Claudius Melzig, Muhammad Taha Hagar, Hans-Ulrich Kauczor, Tim F. Weber, Fabian Rengier, Thuy D. Do
Reduced iodine loads for computed tomography (CT)-based vascular assessment prior to transcatheter aortic valve implantation (TAVI) may be feasible in conjunction with a spectral detector CT scanner. This prospective single-center study considered 100 consecutive patients clinically referred for pre-TAVI CT. They were examined on a dual-layer detector CT scanner to obtain an ECG-gated cardiac scan
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Immune Responses of Healthy Pregnant Women following an Elective Cesarean Section: Effects of Anesthetic Procedures Diagnostics (IF 3.6) Pub Date : 2024-04-24 Marius Bogdan Novac, Lidia Boldeanu, Anda Lorena Dijmărescu, Mihail Virgil Boldeanu, Simona Daniela Neamțu, Lucreţiu Radu, Maria Magdalena Manolea, Mircea-Sebastian Șerbănescu, Maria Stoica, Luciana Teodora Rotaru, Constantin-Cristian Văduva
A weakened immune system and more inflammatory cytokines being released are possible effects of the surgical stress that a cesarean section induces. This kind of reaction, in addition to the altered reaction to catecholamines, has the potential to significantly affect the immune system of the mother and the patients’ general postoperative course. This prospective study compared the plasma levels of
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Differential Diagnosis of Solid Pancreatic Lesions Using Detective Flow Imaging Endoscopic Ultrasonography Diagnostics (IF 3.6) Pub Date : 2024-04-24 Haruo Miwa, Kazuya Sugimori, Shoichiro Yonei, Hayato Yoshimura, Kazuki Endo, Ritsuko Oishi, Akihiro Funaoka, Hiromi Tsuchiya, Takashi Kaneko, Kazushi Numata, Shin Maeda
The differential diagnosis of solid pancreatic lesions (SPLs) using B-mode endoscopic ultrasonography (EUS) is challenging. Detective flow imaging (DFI) offers the potential for detecting low-flow vessels in the pancreas, thus enhancing diagnostic accuracy. This retrospective study aimed to investigate DFI-EUS findings of SPLs and analyze their differential diagnostic accuracy for pancreatic cancer
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Spontaneous Intracranial Hypotension: Case Report and Update on Diagnosis and Treatment Diagnostics (IF 3.6) Pub Date : 2024-04-24 Maria Carolina Jurcau, Anamaria Jurcau, Vlad Octavian Hogea, Razvan Gabriel Diaconu
Spontaneous intracranial hypotension (SIH) is an important cause of daily headaches that occur in young and middle-aged, active persons and is often misdiagnosed, leading to prolonged inactivity and rather high healthcare expenditures. Its diagnosis requires a high degree of clinical suspicion and careful interpretation of imaging studies. We present a case of SIH, which was successfully treated but
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Patlak Slope versus Standardized Uptake Value Image Quality in an Oncologic PET/CT Population: A Prospective Cross-Sectional Study Diagnostics (IF 3.6) Pub Date : 2024-04-24 Semra Ince, Richard Laforest, Malak Itani, Vikas Prasad, Saeed Ashrafinia, Anne M. Smith, Richard L. Wahl, Tyler J. Fraum
Patlak slope (PS) images have the potential to improve lesion conspicuity compared with standardized uptake value (SUV) images but may be more artifact-prone. This study compared PS versus SUV image quality and hepatic tumor-to-background ratios (TBRs) at matched time points. Early and late SUV and PS images were reconstructed from dynamic positron emission tomography (PET) data. Two independent, blinded
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Videoautopsy—A Minimally Invasive Autopsy Method Using Endoscopic Techniques in Forensic Medicine: Clinical Features Diagnostics (IF 3.6) Pub Date : 2024-04-24 Paweł Świderski, Szymon Rzepczyk, Beata Bożek, Czesław Żaba
In light of falling global autopsy rates, one of the causes of which is the resulting body disfigurement, it has become crucial to search for new, minimally invasive post-mortem diagnostic tools. One of these methods is videoautopsy, a minimally invasive autopsy technique using endoscopic methods. In the years 2020–2023, 15 videoautopsies were conducted at the Department of Forensic Medicine of the
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Functional Exercise Capacity and Perceived Exertion in Patients with Empty Nose Syndrome Diagnostics (IF 3.6) Pub Date : 2024-04-24 Wei-Te Hung, Ta-Jen Lee, Pei-Wen Wu, Chi-Che Huang, Po-Hung Chang, Chien-Chia Huang
Empty nose syndrome (ENS) is a complex condition characterized by symptoms such as dyspnea, nasal discomfort, and emotional challenges. This study aimed to evaluate functional exercise capacity and perceived exertion in patients with ENS. Patients with ENS who presented with a range of severe symptoms were prospectively enrolled. Pulmonary function was evaluated using spirometry, and functional exercise
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Comparison of Ultrasound Attenuation Imaging Using a Linear versus a Conventional Convex Probe: A Volunteer Study Diagnostics (IF 3.6) Pub Date : 2024-04-24 Olivia Hänni, Lisa Ruby, Catherine Paverd, Thomas Frauenfelder, Marga B. Rominger, Alexander Martin
The study aimed to investigate the feasibility of attenuation imaging (ATI) measurements using a linear probe on healthy volunteers and compare measurements with the conventional convex probe. Attenuation imaging measurements of the liver tissue were taken using ultrasound with a convex and a linear probe in 33 volunteers by two examining doctors, and the measurements were repeated 4–5 weeks later
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Correlations between Dental Age, Skeletal Age, and Mandibular Morphologic Index Changes in Turkish Children in Eastern Anatolia and Their Chronological Age during the Pubertal Growth Spurt Period: A Cross-Sectional Study Diagnostics (IF 3.6) Pub Date : 2024-04-24 Fatma Saraç, Büşra Baydemir Kılınç, Periş Çelikel, Murat Büyüksefil, Muhammet Burak Yazıcı, Sera Şimşek Derelioğlu
In age determination, different methods aiming to obtain the closest result to chronological age have been investigated so far. The most commonly used one among these is the radiological method, which is usually used to evaluate the developmental stages of wrist bones or teeth. In our study, we assessed bone age estimations using the Gilsanz–Ratib atlas (GRA), which has recently become commonly used
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Null Mismatch Repair Proteins Expression Reveals the Temporal Molecular Events in Lynch Syndrome-Related Cancers Diagnostics (IF 3.6) Pub Date : 2024-04-24 Gianmaria Miolo, Wally Marus, Angela Buonadonna, Lucia Da Ros, Lara Della Puppa, Giuseppe Corona
The immunohistochemical assessment of mismatch repair (MMR) proteins represents a pivotal screening tool for identifying Lynch syndrome (LS)-related cancers, as the loss of their expression often indicates MMR dysfunction associated with genetic or epigenetic alterations. Frequently, LS-related colorectal cancers present germline pathogenic variants in the MLH1 or MSH2 genes, which result in the simultaneous
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Optimizing Oxygen Delivery by Low-Flow Nasal Cannula to Small Infants: A Bench Study Diagnostics (IF 3.6) Pub Date : 2024-04-24 Aris Bertzouanis, Xenophon Sinopidis, Polyxeni Pelekouda, Ageliki Karatza, Gabriel Dimitriou, Sotirios Fouzas
Background: In infants treated with a low-flow nasal cannula (LFNC), the oxygen concentration delivered to the lungs (i.e., the effective FiO2) is difficult to estimate. The existing mathematical formulas rely on important assumptions regarding the values of respiratory parameters and, thus, may be inaccurate. We aimed to assess oxygen delivery by LFNC to small infants using realistic simulations on
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The Detection of Pulp Stones with Automatic Deep Learning in Panoramic Radiographies: An AI Pilot Study Diagnostics (IF 3.6) Pub Date : 2024-04-24 Ali Altındağ, Serkan Bahrilli, Özer Çelik, İbrahim Şevki Bayrakdar, Kaan Orhan
This study aims to evaluate the effectiveness of employing a deep learning approach for the automated detection of pulp stones in panoramic imaging. A comprehensive dataset comprising 2409 panoramic radiography images (7564 labels) underwent labeling using the CranioCatch labeling program, developed in Eskişehir, Turkey. The dataset was stratified into three distinct subsets: training (n = 1929, 80%
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Peroral Pancreatoscopy-Guided Lithotripsy Compared with Extracorporeal Shock Wave Lithotripsy in the Management of Pancreatic Duct Stones in Chronic Pancreatitis: A Multicenter Retrospective Cohort Study Diagnostics (IF 3.6) Pub Date : 2024-04-24 Keisuke Iwata, Takuji Iwashita, Tsuyoshi Mukai, Yuhei Iwasa, Mitsuru Okuno, Kensaku Yoshida, Akinori Maruta, Shinya Uemura, Ichiro Yasuda, Masahito Shimizu
Background: Extracorporeal shock wave lithotripsy (ESWL) is a common treatment for pancreatic stones in chronic pancreatitis. In contrast, peroral pancreatoscopy-guided lithotripsy (POPS-L) remains underexplored, with limited comparative studies to ESWL. This study compared the treatment outcomes of disposable POPS-L tools and ESWL for pancreatic stones. Methods: A retrospective analysis was conducted
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Myxofibrosarcoma of the Chest Wall Detected on 99mTc-MDP Whole-Body Bone Scan Diagnostics (IF 3.6) Pub Date : 2024-04-22 Chia-Hsuan Lee, Hueng-Yuan (Daniel) Shen, Yow-Ling (Shirley) Shiue, Hung-Yen Chan, Hung-Pin Chan
Myxofibrosarcoma is a type of soft tissue sarcoma, predominantly characterized by a high propensity for local recurrence, albeit demonstrating a relatively diminished risk for distant metastasis. Its prevalence is notably higher in elderly patients. Here, we present a case of a 73-year-old woman diagnosed with Myxofibrosarcoma. She was subjected to a whole-body bone scan using 99mTc-methylene diphosphonate
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Diabetes Mellitus and Pneumococcal Pneumonia Diagnostics (IF 3.6) Pub Date : 2024-04-22 Catia Cilloniz, Antoni Torres
Currently, there are more than 500 million people suffering from diabetes around the world. People aged 65 years or older are the most affected by this disease, and it is estimated that approximately 96% of diabetes cases worldwide are type 2 diabetes. People with diabetes mellitus are at an increased risk of infections such as pneumonia, due to a series of factors that may contribute to immune dysfunction
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Does the Use of Intraoperative Neuromonitoring during Thyroid and Parathyroid Surgery Reduce the Incidence of Recurrent Laryngeal Nerve Injuries? A Systematic Review and Meta-Analysis Diagnostics (IF 3.6) Pub Date : 2024-04-23 Andrew Saxe, Mohamed Idris, Jickssa Gemechu
Injury to the recurrent laryngeal nerve (RLN) can be a devastating complication of thyroid and parathyroid surgery. Intraoperative neuromonitoring (IONM) has been proposed as a method to reduce the number of RLN injuries but the data are inconsistent. We performed a meta-analysis to critically assess the data. After applying inclusion and exclusion criteria, 60 studies, including five randomized trials
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The Importance of Microbiota and Fecal Microbiota Transplantation in Pancreatic Disorders Diagnostics (IF 3.6) Pub Date : 2024-04-23 Adrian Boicean, Cristian Ichim, Samuel Bogdan Todor, Paula Anderco, Mirela Livia Popa
The role of the intestinal microbiota in the diagnosis and treatment of pancreatic diseases is increasingly significant. Consequently, fecal microbiota transplantation (FMT) is emerging as a promising therapeutic avenue for various pancreatic disorders, including cancer, pancreatitis, and type 1 diabetes (T1D). This innovative procedure entails transferring gut microbiota from healthy donors to individuals
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Clinical and Radiological Outcomes of Accessory Renal Artery Exclusion during Endovascular Repair of Abdominal Aortic Aneurysms Diagnostics (IF 3.6) Pub Date : 2024-04-23 Alessia Di Girolamo, Marta Ascione, Francesca Miceli, Alireza Mohseni, Chiara Pranteda, Pasqualino Sirignano, Maurizio Taurino, Luca di Marzo, Wassim Mansour
Background: Accessory renal arteries (ARAs) frequently coexist with abdominal aortic aneurysms (AAA) and can influence treatment. This study aimed to retrospectively analyze the ARA’s exclusion effect on patients undergoing standard endovascular aneurysm repair for AAA. Methods: The study focused on medium- and long-term outcomes, including type II endoleak, aneurysmal sac changes, mortality, reoperation
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Could Capsule Endoscopy Be Useful in Detection of Suspected Small Bowel Bleeding and IBD-10 Years of Single Center Experience Diagnostics (IF 3.6) Pub Date : 2024-04-23 Jelena Martinov Nestorov, Aleksandra Sokic-Milutinovic, Aleksandra Pavlovic Markovic, Miodrag Krstic
A retrospective study in patients who underwent video capsule endoscopy (VCE) between 2006 and 2016 was conducted in the Clinic for gastroenterology and Hepatology, University Clinical Center of Serbia. A total of 245 patients underwent VCE. In 198 patients the indication was obscure gastrointestinal bleeding (OGIB), with 92 patients having overt and the other 106 occult bleeding. The remaining 47
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Visual Function Improvement after Plasma Exchange Therapy for Acute Optic Neuritis in Neuromyelitis Optica Spectrum Disorders: Case Series and Review Diagnostics (IF 3.6) Pub Date : 2024-04-23 Raluca Iancu, Ruxandra Pirvulescu, Nicoleta Anton, George Iancu, Sinziana Istrate, Mihaela Oana Romanitan, Aida Geamanu, Matei Popa Cherecheanu
Objective: Neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune-mediated central nervous system disorders distinguished by the presence of serum aquaporine-4 IgG antibody (AQP4-Ab). The clinical panel comprises severe optic neuritis (ON) and transverse myelitis, which can result in incomplete recovery and a high risk of recurrence. Methods: This study aimed to
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Artificial Intelligence Provides Accurate Quantification of Thoracic Aortic Enlargement and Dissection in Chest CT Diagnostics (IF 3.6) Pub Date : 2024-04-23 Nicola Fink, Basel Yacoub, U. Joseph Schoepf, Emese Zsarnoczay, Daniel Pinos, Milan Vecsey-Nagy, Saikiran Rapaka, Puneet Sharma, Jim O’Doherty, Jens Ricke, Akos Varga-Szemes, Tilman Emrich
This study evaluated a deep neural network (DNN) algorithm for automated aortic diameter quantification and aortic dissection detection in chest computed tomography (CT). A total of 100 patients (median age: 67.0 [interquartile range 55.3/73.0] years; 60.0% male) with aortic aneurysm who underwent non-enhanced and contrast-enhanced electrocardiogram-gated chest CT were evaluated. All the DNN measurements
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New Radiological Corticalization Index as an Indicator of Implant Success Rate Depending on Prosthetic Restoration—5 Years of Follow-Up Diagnostics (IF 3.6) Pub Date : 2024-04-23 Tomasz Wach, Jakub Okulski, Rafał Zieliński, Grzegorz Trybek, Adam Michcik, Marcin Kozakiewicz
The new Radiological Corticalization Index (CI) is an indicator that describes bone remodeling near the dental implant’s neck at the pixel level and is not visible to the naked eye. The aim of this research was to evaluate the correlation between the CI and bone remodeling using only radiographic (RTG) images. RTG samples were divided into groups depending on prosthetic restoration; the implant neck
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Comparison of Bone Mineral Density and Trabecular Bone Score in Patients with and without Vertebral Fractures and Differentiated Thyroid Cancer with Long-Term Serum Thyrotrophin-Suppressed Therapy Diagnostics (IF 3.6) Pub Date : 2024-04-23 Federico Hawkins Carranza, Cristina Martin-Arriscado Arroba, María Begoña López Alvarez, Soledad Librizzi, Guillermo Martínez Díaz Guerra
Introduction: The study of BMD provides only partial information on bone health in patients undergoing TSH suppression therapy due to differentiated thyroid cancer (DTC). The trabecular bone score (TBS), a new parameter assessing bone microarchitecture, is proposed for studying bone in this context. This study aimed to analyze their long-term use in patients with DTC. Methods: Bone mineral density
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Postpartum Depression: Etiology, Treatment, and Consequences for Maternal Care Diagnostics (IF 3.6) Pub Date : 2024-04-23 Daiana Anne-Marie Dimcea, Răzvan-Cosmin Petca, Mihai Cristian Dumitrașcu, Florica Șandru, Claudia Mehedințu, Aida Petca
Postpartum depression (PPD) is a disabling condition that has recently shown an increase in prevalence, becoming an essential public health problem. This study is a qualitative review summarizing the most frequent risk factors associated with PPD, evaluating molecular aspects of PPD and current approaches to detect and prevent PPD. The most prevalent risk factors were detected in the areas of economic
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Risk Factors and Scoring Systems to Predict the Mortality Risk of Afebrile Adult Patients with Monomicrobial Gram-Negative Bacteremia: A 10-Year Observational Study in the Emergency Department Diagnostics (IF 3.6) Pub Date : 2024-04-23 Chung-Pang Wang, Ming-Shun Hsieh, Sung-Yuan Hu, Shih-Che Huang, Che-An Tsai, Chia-Hui Shen
Background: The mortality rate of afebrile bacteremia has been reported to be as high as 45%. This investigation focused on the risk factors and predictive performance of scoring systems for the clinical outcomes of afebrile patients with monomicrobial gram-negative bacteria (GNB) in the emergency department (ED). Methods: We conducted a retrospective analysis of afebrile adult ED patients with monomicrobial
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Comparison of Early Contrast Enhancement Models in Ultrafast Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Prostate Cancer Diagnostics (IF 3.6) Pub Date : 2024-04-23 Alfredo Clemente, Guerino Selva, Michael Berks, Federica Morrone, Aniello Alessandro Morrone, Michele De Cristofaro Aulisa, Ekaterina Bliakharskaia, Andrea De Nicola, Armando Tartaro, Paul E. Summers
Tofts models have failed to produce reliable quantitative markers for prostate cancer. We examined the differences between prostate zones and lesion PI-RADS categories and grade group (GG) using regions of interest drawn in tumor and normal-appearing tissue for a two-compartment uptake (2CU) model (including plasma volume (vp), plasma flow (Fp), permeability surface area product (PS), plasma mean transit
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Comparison of Functional Outcomes after Anterior Cruciate Ligament Reconstruction with Meniscal Repair for Unstable Versus Stable Meniscal Tears Diagnostics (IF 3.6) Pub Date : 2024-04-23 Jin Hyuck Lee, Gyu Bin Lee, WooYong Chung, Ji Won Wang, Sun Gyu Han, Hye Chang Rhim, Seung-Beom Han, Ki-Mo Jang
: This study aimed to compare functional outcomes including knee muscle strength in the quadriceps and hamstrings, and proprioception, assessed through dynamic postural stability (overall stability index [OSI]) and self-reported outcomes in the operated and non-operated knees between anterior cruciate ligament reconstruction (ACLR) with meniscal repair for unstable (root and radial tears) and stable
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Integrating Patient-Based Real-Time Quality Control (PBRTQC) in a New Field: Inter-Comparison between Biochemical Instrumentations with LDL-C Diagnostics (IF 3.6) Pub Date : 2024-04-23 Jingyuan Wang, Chedong Zhao, Linlin Fan, Xiaoqin Wang
Background: Patient-based real-time quality control (PBRTQC) can be a valuable tool in clinical laboratories due to its cost-effectiveness and constant monitoring. More focus is placed on discovering and improving algorithms that compliment conventional internal control techniques. The practical implementation of PBRTQC with a biochemical instrument comparison is lacking. We aim to evaluate PBRTQC’s
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Sonographic Features of Uterine Arteriovenous Malformation: A Case Series Diagnostics (IF 3.6) Pub Date : 2024-04-23 Dhammapoj Jeerakornpassawat, Charuwan Tantipalakorn, Sirinart Sirilert, Theera Tongsong
Uterine arteriovenous malformation (AVM) is very rare but potentially life-threatening. Early and accurate diagnosis is the cornerstone of its management. The objective of this study is to encourage sonographers to become familiar with a variety of grayscale sonographic features, facilitating rapid recognition of the patterns and prompting them to apply color flow Doppler for a diagnosis of uterine
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Changes in Outcomes of Macular Optical Coherence Tomography Angiography Following Surgery for Optic Disc Pit Maculopathy Diagnostics (IF 3.6) Pub Date : 2024-04-23 Melih Akıdan, Muhammet Kazım Erol, Birumut Gedik, Mehmet Erkan Doğan, Ibrahim Başol, Elçin Süren
Purpose: we aimed to report on the optical coherence tomography angiography (OCTA) outcomes of eight patients with optic disc pit maculopathy (ODP-M) who were treated with 23-gauge pars plana vitrectomy (PPV). Methods: We examined sixteen eyes of eight patients—eight eyes with ODP-M and eight healthy fellow eyes. Fundus color photography, fundus autofluorescence, fundus fluorescein angiography, optical
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A Late Testicular Relapse in an Adult with Acute Lymphoblastic Leukemia, 5 Years after the Diagnosis and 4 Years after Allotransplant—A Rare Case Diagnostics (IF 3.6) Pub Date : 2024-04-23 Andrei Epure, C Florin Pop, Ciprian Juravle, Florin Grosu, Carmen Naicu
Acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid progenitor cells that affects both pediatric and adult populations. Although isolated testicular or any other organ recurrence can occur in the pediatric population, it is rare in adults. We present images for an atypical case of the late testicular recurrence of acute lymphoblastic leukemia in a 56-year-old man previously diagnosed
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Fecal Calprotectin in Patients with Crohn’s Disease: A Study Based on the History of Bowel Resection and Location of Disease Diagnostics (IF 3.6) Pub Date : 2024-04-22 Jeongkuk Seo, Subin Song, Seung Hwan Shin, Suhyun Park, Seung Wook Hong, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sung Wook Hwang
Fecal calprotectin (FC) is commonly used to assess Crohn’s disease (CD) activity. However, standardized cut-off values accounting for bowel resection history and disease location are lacking. In this study, we analyzed data from patients with CD who underwent magnetic resonance enterography, ileocolonoscopy, and FC measurements from January 2017 to December 2018. In 267 cases from 254 patients, the
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Endoscopic Retrograde Cholangiopancreatography (ERCP) for Suspected Mirizzi Syndrome Type IV as Both a Diagnostic and Bridge-to-Surgery Procedure Diagnostics (IF 3.6) Pub Date : 2024-04-22 Giacomo Emanuele Maria Rizzo, Settimo Caruso, Ilaria Tarantino
Mirizzi syndrome (MS) is a challenging diagnosis due to its similar presentation with other biliary diseases; thus, the role of endoscopy is sometimes unclear, especially in altered anatomy. Radiological examinations may usually suspect it, but deeper examinations could be necessary to confirm it. Endoscopic retrograde cholangiopancreatography (ERCP) certainly has a therapeutic role in cases of jaundice
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Breaking Sound Barriers: Exploring Tele-Audiology’s Impact on Hearing Healthcare Diagnostics (IF 3.6) Pub Date : 2024-04-22 Mien-Jen Lin, Chin-Kuo Chen
Hearing impairment is a global issue, affecting billions of people; however, there is a gap between the population affected by hearing loss and those able to access hearing healthcare. Tele-audiology, the application of telemedicine in audiology, serves as a new form of technology which aims to provide synchronous or asynchronous hearing healthcare. In this article, we reviewed some recent studies
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The Dual Lens of Endoscopy and Histology in the Diagnosis and Management of Eosinophilic Gastrointestinal Disorders—A Comprehensive Review Diagnostics (IF 3.6) Pub Date : 2024-04-22 Alberto Barchi, Edoardo Vespa, Sandro Passaretti, Giuseppe Dell’Anna, Ernesto Fasulo, Mona-Rita Yacoub, Luca Albarello, Emanuele Sinagra, Luca Massimino, Federica Ungaro, Silvio Danese, Francesco Vito Mandarino
Eosinophilic Gastrointestinal Disorders (EGIDs) are a group of conditions characterized by abnormal eosinophil accumulation in the gastrointestinal tract. Among these EGIDs, Eosinophilic Esophagitis (EoE) is the most well documented, while less is known about Eosinophilic Gastritis (EoG), Eosinophilic Enteritis (EoN), and Eosinophilic Colitis (EoC). The role of endoscopy in EGIDs is pivotal, with applications
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Predictors of Early Continence Recovery Following Radical Prostatectomy, Including Transperineal Ultrasound to Evaluate the Membranous Urethra Length (CHECK-MUL Study) Diagnostics (IF 3.6) Pub Date : 2024-04-21 Bara Barakat, Mustapha Addali, Boris Hadaschik, Christian Rehme, Sameh Hijazi, Samy Zaqout
Introduction: To predict early continence recovery following radical prostatectomy (RP) using baseline demographic and clinical data, as well as dynamic transperineal ultrasound (TPUS) parameters of membranous urethral length (MUL). Patients and Methods: A retrospective CHECK-MUL (check of membranous urethral length) study was conducted. We evaluated 154 patients who underwent RP between August 2018
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Advanced Respiratory Failure Requiring Tracheostomy—A Marker of Unfavourable Prognosis after Heart Transplantation Diagnostics (IF 3.6) Pub Date : 2024-04-20 Marta Załęska-Kocięcka, Marco Morosin, Jonathan Dutton, Rita Fernandez Garda, Katarzyna Piotrowska, Nicholas Lees, Tuan-Chen Aw, Diana Garcia Saez, Ana Hurtado Doce
Advanced respiratory failure with tracheostomy requirement is common in heart recipients. The aim of the study is to assess the tracheostomy rate after orthotopic heart transplantation and identify the subgroups of patients with the highest need for tracheostomy and these groups’ association with mortality at a single centre through a retrospective analysis of 140 consecutive patients transplanted
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Multidisciplinarity and Trandisciplinarity in the Diagnosis and Treatment of Pediatric Gastrointestinal Diseases Diagnostics (IF 3.6) Pub Date : 2024-04-20 Cristina Oana Mărginean
It is an honor and a privilege to have helped bring this Special Issue titled “Multidisciplinarity and Trandisciplinarity in the Diagnosis and Treatment of Pediatric Gastrointestinal Diseases” to you [...]
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The Role of CT Imaging in a Fractured Coronary Stent with Pseudoaneurysm Formation Diagnostics (IF 3.6) Pub Date : 2024-04-18 Radu Octavian Baz, George Gherghescu, Adnan Mustafa, Mihaly Enyedi, Cristian Scheau, Radu Andrei Baz
We report a case of a 63-year-old male patient with multiple cardiovascular risk factors and previous myocardial infarction who was referred to the emergency department on September 2023 with symptoms and clinical and biological data consistent with an acute coronary event. A coronary angiography revealed severe ostial stenosis of the left anterior descending artery (LAD) and intrastent thrombotic
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Could Phosphorous MR Spectroscopy Help Predict the Severity of Vasospasm? A Pilot Study Diagnostics (IF 3.6) Pub Date : 2024-04-18 Malik Galijasevic, Ruth Steiger, Stephanie Alice Treichl, Wing Man Ho, Stephanie Mangesius, Valentin Ladenhauf, Johannes Deeg, Leonhard Gruber, Miar Ouaret, Milovan Regodic, Lukas Lenhart, Bettina Pfausler, Astrid Ellen Grams, Ondra Petr, Claudius Thomé, Elke Ruth Gizewski
One of the main causes of the dismal prognosis in patients who survive the initial bleeding after aneurysmal subarachnoidal hemorrhage is the delayed cerebral ischaemia caused by vasospasm. Studies suggest that cerebral magnesium and pH may potentially play a role in the pathophysiology of this adverse event. Using phosphorous magnetic resonance spectrocopy (31P-MRS), we calculated the cerebral magnesium
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Opportunistic CT for Prediction of Adverse Postoperative Events in Patients with Spinal Metastases Diagnostics (IF 3.6) Pub Date : 2024-04-19 Neal D. Kapoor, Olivier Q. Groot, Colleen G. Buckless, Peter K. Twining, Michiel E. R. Bongers, Stein J. Janssen, Joseph H. Schwab, Martin Torriani, Miriam A. Bredella
The purpose of this study was to assess the value of body composition measures obtained from opportunistic abdominal computed tomography (CT) in order to predict hospital length of stay (LOS), 30-day postoperative complications, and reoperations in patients undergoing surgery for spinal metastases. 196 patients underwent CT of the abdomen within three months of surgery for spinal metastases. Automated
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CT Perfusion Derived rCBV < 42% Lesion Volume Is Independently Associated with Followup FLAIR Infarct Volume in Anterior Circulation Large Vessel Occlusion Diagnostics (IF 3.6) Pub Date : 2024-04-19 Dhairya A. Lakhani, Aneri B. Balar, Hamza Salim, Manisha Koneru, Sijin Wen, Burak Ozkara, Hanzhang Lu, Richard Wang, Meisam Hoseinyazdi, Risheng Xu, Mehreen Nabi, Ishan Mazumdar, Andrew Cho, Kevin Chen, Sadra Sepehri, Nathan Hyson, Victor Urrutia, Licia Luna, Argye E. Hillis, Jeremy J. Heit, Greg W. Albers, Ansaar T. Rai, Adam A. Dmytriw, Tobias D. Faizy, Max Wintermark, Kambiz Nael, Vivek S. Yedavalli
Pretreatment CT Perfusion (CTP) parameter rCBV < 42% lesion volume has recently been shown to predict 90-day mRS. In this study, we aim to assess the relationship between rCBV < 42% and a radiographic follow-up infarct volume delineated on FLAIR images. In this retrospective evaluation of our prospectively collected database, we included acute stroke patients triaged by multimodal CT imaging, including
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Illuminating the Genetic Basis of Congenital Heart Disease in Patients with Kabuki Syndrome Diagnostics (IF 3.6) Pub Date : 2024-04-19 Chung-Lin Lee, Chih-Kuang Chuang, Ming-Ren Chen, Ju-Li Lin, Huei-Ching Chiu, Ya-Hui Chang, Yuan-Rong Tu, Yun-Ting Lo, Hsiang-Yu Lin, Shuan-Pei Lin
Congenital heart defects (CHDs) affect a substantial proportion of patients with Kabuki syndrome. However, the prevalence and type of CHD and the genotype–phenotype correlations in Asian populations are not fully elucidated. This study performed a retrospective analysis of 23 Taiwanese patients with molecularly confirmed Kabuki syndrome. Twenty-two patients presented with pathogenic variants in the
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A Lateral-Flow Device for the Rapid Detection of Scedosporium Species Diagnostics (IF 3.6) Pub Date : 2024-04-19 Genna E. Davies, Christopher R. Thornton
Scedosporium species are human pathogenic fungi, responsible for chronic, localised, and life-threatening disseminated infections in both immunocompetent and immunocompromised individuals. The diagnosis of Scedosporium infections currently relies on non-specific CT, lengthy and insensitive culture from invasive biopsy, and the time-consuming histopathology of tissue samples. At present, there are no
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Deep Learning in Breast Cancer Imaging: State of the Art and Recent Advancements in Early 2024 Diagnostics (IF 3.6) Pub Date : 2024-04-19 Alessandro Carriero, Léon Groenhoff, Elizaveta Vologina, Paola Basile, Marco Albera
The rapid advancement of artificial intelligence (AI) has significantly impacted various aspects of healthcare, particularly in the medical imaging field. This review focuses on recent developments in the application of deep learning (DL) techniques to breast cancer imaging. DL models, a subset of AI algorithms inspired by human brain architecture, have demonstrated remarkable success in analyzing
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Comprehensive Investigation of Angiogenesis, PASS Score and Immunohistochemical Factors in Risk Assessment of Malignancy for Paraganglioma and Pheochromocytoma Diagnostics (IF 3.6) Pub Date : 2024-04-19 Marija Milinkovic, Ivan Soldatovic, Vladan Zivaljevic, Vesna Bozic, Maja Zivotic, Svetislav Tatic, Dusko Dundjerovic
A challenging task in routine practice is finding the distinction between benign and malignant paragangliomas and pheochromocytomas. The aim of this study is to conduct a comparative analysis of angiogenesis by assessing intratumoral microvascular density (MVD) with immunohistochemical (IHC) markers (CD31, CD34, CD105, ERG), and S100 immunoreactivity, Ki67 proliferative index, succinate dehydrogenase
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Hyperacute Radiation Pneumonitis after Severe irAE Diagnostics (IF 3.6) Pub Date : 2024-04-19 Yang Chou, Wei-Kai Chuang
A 54-year-old woman presented to an outpatient clinic with a recurrence of triple-negative breast cancer and multiple bone metastases. The patient had a large mass lesion of 10 cm on the sternum. She received the immune checkpoint inhibitors pembrolizumab and taxane. Initially, the patient responded excellently to treatment, but stopped pembrolizumab for grade IV skin toxicity with multiple ulcerative
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Unselective Measurement of Tumor-to-Stroma Proportion in Colon Cancer at the Invasion Front—An Elusive Prognostic Factor: Original Patient Data and Review of the Literature Diagnostics (IF 3.6) Pub Date : 2024-04-18 Zsolt Fekete, Patricia Ignat, Amelia Cristina Resiga, Nicolae Todor, Alina-Simona Muntean, Liliana Resiga, Sebastian Curcean, Gabriel Lazar, Alexandra Gherman, Dan Eniu
The tumor-to-stroma ratio is a highly debated prognostic factor in the management of several solid tumors and there is no universal agreement on its practicality. In our study, we proposed confirming or dismissing the hypothesis that a simple measurement of stroma quantity is an easy-to-use and strong prognostic tool. We have included 74 consecutive patients with colorectal cancer who underwent primary
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Challenges of Secondary Glaucoma Management Following Congenital Cataract Surgery, Penetrating Keratoplasty and Vitreoretinal Surgery Diagnostics (IF 3.6) Pub Date : 2024-04-18 Valeria Coviltir, Maria-Cristina Corbu, Miruna Gabriela Burcel, Maria-Emilia Cerghedean-Florea, Adrian Hașegan, Ciprian Tănăsescu, Mihaela Laura Vică, Horațiu Dura
Glaucoma is one of the world’s leading causes of irreversible vision loss. It is often asymptomatic until it reaches an advanced stage, which can have a significant impact on patients’ daily lives. This paper describes the case of a 50-year-old female patient who presented with acute onset of ocular pain, photophobia, and loss of visual acuity in her right eye (RE). The patient’s medical history includes
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Multi-Modality Imaging in Vasculitis Diagnostics (IF 3.6) Pub Date : 2024-04-18 Mohamed N. Allam, Nima Baba Ali, Ahmed K. Mahmoud, Isabel G. Scalia, Juan M. Farina, Mohammed Tiseer Abbas, Milagros Pereyra, Moaz A. Kamel, Kamal A. Awad, Yuxiang Wang, Timothy Barry, Steve S. Huang, Ba D. Nguyen, Ming Yang, Clinton E. Jokerst, Felipe Martinez, Chadi Ayoub, Reza Arsanjani
Systemic vasculitides are a rare and complex group of diseases that can affect multiple organ systems. Clinically, presentation may be vague and non-specific and as such, diagnosis and subsequent management are challenging. These entities are typically classified by the size of vessel involved, including large-vessel vasculitis (giant cell arteritis, Takayasu’s arteritis, and clinically isolated aortitis)
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The Role of Large Language Models (LLMs) in Providing Triage for Maxillofacial Trauma Cases: A Preliminary Study Diagnostics (IF 3.6) Pub Date : 2024-04-18 Andrea Frosolini, Lisa Catarzi, Simone Benedetti, Linda Latini, Glauco Chisci, Leonardo Franz, Paolo Gennaro, Guido Gabriele
Background: In the evolving field of maxillofacial surgery, integrating advanced technologies like Large Language Models (LLMs) into medical practices, especially for trauma triage, presents a promising yet largely unexplored potential. This study aimed to evaluate the feasibility of using LLMs for triaging complex maxillofacial trauma cases by comparing their performance against the expertise of a
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A Cost-Effective Model for Predicting Recurrent Gastric Cancer Using Clinical Features Diagnostics (IF 3.6) Pub Date : 2024-04-18 Chun-Chia Chen, Wen-Chien Ting, Hsi-Chieh Lee, Chi-Chang Chang, Tsung-Chieh Lin, Shun-Fa Yang
This study used artificial intelligence techniques to identify clinical cancer biomarkers for recurrent gastric cancer survivors. From a hospital-based cancer registry database in Taiwan, the datasets of the incidence of recurrence and clinical risk features were included in 2476 gastric cancer survivors. We benchmarked Random Forest using MLP, C4.5, AdaBoost, and Bagging algorithms on metrics and
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Association between Pityriasis Rosea (PR) and HHV-6/HHV-7 Infection: Importance of Sample Selection and Diagnostic Techniques Diagnostics (IF 3.6) Pub Date : 2024-04-18 Mine Aydin Kurc, Gamze Erfan, Ayse Demet Kaya, Dumrul Gülen, Meltem Oznur, Mehmet Emin Yanik
Recent studies have focused on the role of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) in PR etiology with varying results. In our study, with the approach that the discrepancy between the results may be related to the different samples and techniques used, we aimed to clarify the etiology by examining tissue and plasma samples using molecular methods and evaluating the results together
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Borderline Ventricles: From Evaluation to Treatment Diagnostics (IF 3.6) Pub Date : 2024-04-16 Giuseppe Antonio Mazza, Lilia Oreto, Giulia Tuo, Domenico Sirico, Sara Moscatelli, Giovanni Meliota, Antonio Micari, Paolo Guccione, Gabriele Rinelli, Silvia Favilli
A heart with a borderline ventricle refers to a situation where there is uncertainty about whether the left or right underdeveloped ventricle can effectively support the systemic or pulmonary circulation with appropriate filling pressures and sufficient physiological reserve. Pediatric cardiologists often deal with congenital heart diseases (CHDs) associated with various degrees of hypoplasia of the
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Comparative Analysis of Vascular Calcification Risk Factors in Pre-Hemodialysis and Prevalent Hemodialysis Adult Patients: Insights into Calcification Biomarker Associations and Implications for Intervention Strategies in Chronic Kidney Disease Diagnostics (IF 3.6) Pub Date : 2024-04-17 Marko Petrović, Voin Brković, Marko Baralić, Ivko Marić, Nenad Petković, Sanja Stanković, Nataša Lalić, Dejana Stanisavljević, Ljubica Đukanović, Višnja Ležaić
This retrospective study aimed to compare risk factors for vascular calcification (VC) between pre-hemodialysis (HD) and prevalent HD adult patients while investigating associations with calcification biomarkers. Baseline data from 30 pre-HD and 85 HD patients were analyzed, including iPTH, vitamin D, FGF 23, fetuin-A, sclerostin, and VC scores (Adragao method). Prevalence of VC was similar in both
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Prenatal Diagnosis and Prognosis of Abdominal Arteriovenous Fistulae: A Comprehensive Case Series and Systematic Review Diagnostics (IF 3.6) Pub Date : 2024-04-17 Anda Ungureanu, Rodica Daniela Nagy, Cristian Constantin, Ioana Andreea Gheonea, Dominic Gabriel Iliescu
This study had two main objectives. Firstly, we conducted a thorough literature review on the prenatal diagnosis of abdominal congenital arteriovenous fistulas (CAVFs) involving the abdominal aorta and hepatic arteries. Secondly, we aimed to provide detailed descriptions of eight additional cases diagnosed at our medical center and assess the outcome of this anomaly for informed counseling. We conducted
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Analyzing Longitudinal Health Screening Data with Feature Ensemble and Machine Learning Techniques: Investigating Diagnostic Risk Factors of Metabolic Syndrome for Chronic Kidney Disease Stages 3a to 3b Diagnostics (IF 3.6) Pub Date : 2024-04-17 Ming-Shu Chen, Tzu-Chi Liu, Mao-Jhen Jhou, Chih-Te Yang, Chi-Jie Lu
Longitudinal data, while often limited, contain valuable insights into features impacting clinical outcomes. To predict the progression of chronic kidney disease (CKD) in patients with metabolic syndrome, particularly those transitioning from stage 3a to 3b, where data are scarce, utilizing feature ensemble techniques can be advantageous. It can effectively identify crucial risk factors, influencing