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Recent Advances in Blood Cell-Inspired and Clot Targeted Thrombolytic Therapies. J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2023-02-17 Anastasia Sheridan,Ashley C Brown
Myocardial infarction, stroke, and pulmonary embolism are all deadly conditions associated with excessive thrombus formation. Standard treatment for these conditions involves systemic delivery of thrombolytic agents to break up clots and restore blood flow; however, this treatment can impact the hemostatic balance in other parts of the vasculature, which can lead to excessive bleeding. To avoid this
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Issue Information J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-12-01
No abstract is available for this article.
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Long-term passages of human clonal mesenchymal stromal cells can alleviate the disease in the rat model of collagen-induced arthritis resembling early passages of different heterogeneous cells J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-27 Mahnaz Babaahmadi, Behnoosh Tayebi, Nima Makvand Gholipour, Phillip Bendele, Jed Pheneger, Abolfazl Kheimeh, Amir Kamali, Mohammad Molazem, Hossein Baharvand, Mohamadreza Baghaban Eslaminejad, Ensiyeh Hajizadeh-Saffar, Seyedeh-Nafiseh Hassani
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease of unknown cause. The interaction of immune system cells and the secretion of inflammatory cytokines with synovial cells leads to severe inflammation in the affected joints. Currently, medications, including non-steroidal anti-inflammatory drugs, glucocorticoids, and more recently, disease-modifying anti-rheumatic drugs, are used to
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Effect of amniotic membrane and platelet-rich fibrin membrane on bone healing post endodontic surgery: An ultrasonographic, randomized controlled study J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-19 Saumya Johri, Promila Verma, Aseem Prakash Tikku, Rhythm Bains, Neera Kohli
The use of membrane barriers and bone grafting materials in endodontic surgery promotes healing by regeneration rather than repair by scar tissue. Due to its valuable regenerative and therapeutic properties, the human amniotic membrane can support ideal periapical rehabilitation and promote better healing after surgery. The current trial aimed to evaluate the amniotic membrane's healing potential and
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Evolution of functional tissue engineering for tendon and ligament repair J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-17 David L. Butler
This review paper is motivated by a Back-to-Basics presentation given by the author at the 2022 Orthopaedic Research Society meeting in Tampa, Florida. I was tasked with providing a brief history of research leading up to the introduction of functional tissue engineering (FTE) for tendon and ligament repair. Beginning in the 1970s, this timeline focused on two common orthopedic soft tissue problems
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Recent advances in gene therapy for bone tissue engineering J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-16 Fatemeh Ranjbarnejad, Mozafar Khazaei, Alireza Shahryari, Fatemeh Khazaei, Leila Rezakhani
Autografting, a major treatment for bone fractures, has potential risks related to the required surgery and disease transmission. Bone morphogenetic proteins (BMPs) are the most common osteogenic factors used for bone-healing applications. However, BMP delivery can have shortcomings such as a short half-life and the high cost of manufacturing the recombinant proteins. Gene delivery methods have demonstrated
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Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-09 Piotr Sass, Paweł Sosnowski, Jolanta Kamińska, Milena Deptuła, Aneta Skoniecka, Jacek Zieliński, Sylwia Rodziewicz-Motowidło, Michał Pikuła, Paweł Sachadyn
DNA methyltransferase inhibitor zebularine was proven to induce regeneration in the ear pinna in mice. We utilized a dorsal skin wound model to further evaluate this epigenetic inhibitor in wound healing. Full-thickness excisional wounds were made on the dorsum of 2 and 10-month-old healthy BALB/c and 3 and 8-month-old diabetic (db/db) mice, followed by topical or intraperitoneal zebularine delivery
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Exosomal let-7f-5p derived from mineralized osteoblasts promotes the angiogenesis of endothelial cells via the DUSP1/Erk1/2 signaling pathway J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-08 Yiqun He, Hailong Li, Zuochong Yu, Linli Li, Xujun Chen, Aolei Yang, Feizhou Lyu, Youhai Dong
Blood vessel formation is the prerequisite for the survival and growth of tissue-engineered bone. Mineralized osteoblasts (MOBs) have been shown to regulate angiogenesis through the secretion of exosomes containing various pro-angiogenic factors. However, whether the mineralized osteoblast-derived exosomes (MOB-Exos) containing let-7f-5p can regulate the angiogenesis of endothelial cells (ECs) is still
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Three-dimensional wet electrospun scaffold system for the differentiation of adipose-derived mesenchymal stem cells to islet-like clusters J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-08 Jijo Wilson, V. G. Rahul, Lynda V. Thomas, Prabha D. Nair
Stem cell-derived islet-like clusters (ILCs) are an alternative source of pancreatic beta cells for the treatment of diabetic mellitus. An ideal 3D culture platform for the generation of ILCs of desired cluster size is a challenge due to the clustering of islet cells in the 2D culture systems. The islet cells cultured in 2D conditions produce clusters of large size, which are less efficient in terms
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Fabrication of BMP-2-peptide–Deferoxamine- and QK-peptide-functionalized nanoscaffolds and their application for bone defect treatment J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-08 Zecheng Li, Shi Cheng, Ang Li, Chengchao Song, Anlong Jiang, Fangxing Xu, Hui Chi, Jinglong Yan, Guanghua Chen
The microenvironment in the healing process of large bone defects requires suitable conditions to promote osteogenesis and angiogenesis. Coaxial electrospinning is a mature method in bone tissue engineering (BTE) and allows functional modification. Appropriate modification methods can be used to improve the bioactivity of scaffolds for BTE. In this study, coaxial electrospinning with QK peptide (a
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Effective decellularization of human skin tissue for regenerative medicine by supercritical carbon dioxide technique J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-08 Nguyen Ngan Giang, Xuan-Tung Trinh, Jeonghun Han, Pham Ngoc Chien, Jua Lee, Seong-Rae Noh, Yongwoo Shin, Sun-Young Nam, Chan-Yeong Heo
Allotransplantation, performed using an acellular dermal matrix (ADM), plays a significant role in the cultivation of constituted and damaged organs in clinical. Herein, we fabricated an innovative ADM for allografting derived from decellularized human skin by utilizing the supercritical fluid of carbon dioxide to eliminate immunogenic components. By using histological staining, the ADM product demonstrated
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Matricellular protein Tenascin-C enhances mesenchymal stem cell angiogenic and wound healing efficacy under ischemic conditions J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-08 Kyle Sylakowski, Peter Hwang, Amritha Justin, Hanshuang Shao, Diana Whaley, Yadong Wang, Alan Wells
Human mesenchymal stem cells/multipotent stromal cells (MSCs) hold great promise in aiding wound healing through their ability to modulate all phases of repair and regeneration, most notably their secretion of pro-regenerative paracrine factors. However, MSC clinical utility is hindered by poor survival rates post-transplantation due to the harsh microenvironment in injured tissue. Previous work has
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Application of amniotic membranes in reconstructive surgery of internal organs—A systematic review and meta-analysis J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-04 Lennart P. Maljaars, Sohayla Bendaoud, Arnoud W. Kastelein, Zeliha Guler, Carlijn R. Hooijmans, Jan-Paul W. R. Roovers
Amniotic membrane (AM) has great potential as a scaffold for tissue regeneration in reconstructive surgery. To date, no systematic review of the literature has been performed for the applications of AM in wound closure of internal organs. Therefore, in this systematic review and meta-analysis, we summarize the literature on the safety and efficacy of AM for the closure of internal organs. A systematic
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The inflammasome in biomaterial-driven immunomodulation J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-03 Daniela P. Vasconcelos, Artur P. Águas, Judite N. Barbosa
Inflammasomes are intracellular structures formed upon the assembly of several proteins that have a considerable size and are very important in innate immune responses being key players in host defense. They are assembled after the perception of pathogens or danger signals. The activation of the inflammasome pathway induces the production of high levels of the pro-inflammatory cytokines Interleukin
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Nanofibrous polytetrafluoroethylene/poly(ε-caprolactone) membrane with hierarchical structures for vascular patch J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-03 Yulu Liu, Ya Liu, Zhiyuan Bai, Dongfang Wang, Yiyang Xu, Qian Li
With the prevalence of cardiovascular diseases, developing cardiovascular supplements is becoming increasingly urgent. The ability of cells to rapidly adhere and proliferate to achieve endothelialization is extremely important for vascular grafts. In this work, we electrospun polytetrafluoroethylene (PTFE) nanofibrous membranes and used induced crystallization to manufacture poly(ε-caprolactone) (PCL)
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Issue Information J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-11-01
No abstract is available for this article.
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Stem cell-based strategies for skeletal muscle tissue engineering J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-10-12 Christofer Baldwin, Johntaehwan Kim, Srikanth Sivaraman, Raj R. Rao
Skeletal muscle tissue engineering has been a key area of focus over the years and has been of interest for developing regenerative strategies for injured or degenerative skeletal muscle tissue. Stem cells have gained increased attention as sources for developing skeletal muscle tissue for subsequent studies or potential treatments. Focus has been placed on understanding the molecular pathways that
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Accelerated vascularization of a novel collagen hydrogel dermal template J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-10-11 Adam Weisel, Rachael Cohen, Jason A. Spector, Yulia Sapir-Lekhovitser
Full thickness skin loss is a debilitating problem, most commonly reconstructed using split thickness skin grafts (STSG), which do not reconstitute normal skin thickness and often result in suboptimal functional and esthetic outcomes that diminish a patient's quality of life. To address the minimal dermis present in most STSG, engineered dermal templates were developed that can induce tissue ingrowth
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In vitro testing and efficacy of poly-lactic acid coating incorporating antibiotic loaded coralline bioceramic on Ti6Al4V implant against Staphylococcus aureus J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-10-07 Ipek Karacan, Besim Ben-Nissan, Jerran Santos, Stanley Yiu, Peta Bradbury, Stella M. Valenzuela, Joshua Chou
Biofilm formation on an implant surface is most commonly caused by the human pathogenic bacteria Staphylococcus aureus, which can lead to implant related infections and failure. It is a major problem for both implantable orthopedic and maxillofacial devices. The current antibiotic treatments are typically delivered orally or in an injectable form. They are not highly effective in preventing or removing
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Issue Information J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-10-01
No abstract is available for this article.
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Cartilage-penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-09-30 Michael A. Kowalski, Lorenzo M. Fernandes, Kyle E. Hammond, Sameh Labib, Hicham Drissi, Jay M. Patel
Articular cartilage injuries have a limited healing capacity and, due to inflammatory and catabolic activities, often experience progressive degeneration towards osteoarthritis. Current repair techniques generally provide short-term symptomatic relief; however, the regeneration of hyaline cartilage remains elusive, leaving both the repair tissue and surrounding healthy tissue susceptible to long-term
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In-depth analysis of the relationship between bovine intestinal organoids and enteroids based on morphology and transcriptome J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-09-20 Juntao Zhang, Juanjuan Li, Penghui Yan, Laizeng He, Xuemei Zhang, Xiaolong Wang, Yake Shi, Lixin Deng, ZhiPing Zhang, Baoyu Zhao
Intestinal organoids and enteroids as excellent models are miniaturized and simplified for studying intestinal physiological and pathological functions, drug screening, and regenerative medicine. Recently, the application demands for organoids and enteroids in organ development and nutrition metabolism, immune and cancer research increased. But there are few comparative studies on both of them, especially
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FlexMetric bone marrow aspirator yields laboratory and clinically improved results from mesenchymal stem and progenitor cells without centrifugation J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-09-16 Robert E. Marx, Paul Amailuk, Neel Patel, Andre Ledoux, Dani Stanbouly
Several devices used to harvest stem/progenitor cells from bone marrow are available to clinicians. This study compared three devices measuring stem cell yields and correlating those yields to bone regeneration. A flexible forward aspirating system Marrow Marxman (MM), a straight needle aspirating on withdrawal system Marrow Cellutions (MC), and a straight needle aspirating on withdrawal and centrifuging
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Therapeutic approaches to activate the canonical Wnt pathway for bone regeneration J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-09-16 Anna Laura Nelson, GianLuca Fontana, Elizabeth Miclau, Mallory Rongstad, William Murphy, Johnny Huard, Nicole Ehrhart, Chelsea Bahney
Activation of the canonical Wingless-related integration site (Wnt) pathway has been shown to increase bone formation and therefore has therapeutic potential for use in orthopedic conditions. However, attempts at developing an effective strategy to achieve Wnt activation has been met with several challenges. The inherent hydrophobicity of Wnt ligands makes isolating and purifying the protein difficult
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Zwitterionic keratin coating on silk-Laponite fibrous membranes for guided bone regeneration J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-09-12 Matineh Atrian, Mahshid Kharaziha, Hanieh Javidan, Farzaneh Alihosseini, Rahmatallah Emadi
Implant-related infection is one of the main challenges in periodontal diseases. According to the zwitterionic properties of keratin, we aim to develop guided bone regeneration (GBR) membrane with antibacterial and bioactivity properties using a keratin coating. In this study, electrospun silk fibroin (SF)–Laponite (LAP) fibrous membranes were developed as GBR membranes, and keratin extracted from
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Issue Information J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-09-01
No abstract is available for this article.
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Corrigendum J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-09-01
In the article entitled “A review of diabetic wound models—Novel insights into diabetic foot ulcer”, Phang et al., 2021 the grant number in funding information has been corrected as below: Ministry of Higher Education Malaysia Fundamental Research Grant Scheme, FRGS/1/2019/SKK08/UM/02/29 We apologize for this error.
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Biomaterials directed activation of a cryostable therapeutic secretome in induced pluripotent stem cell derived mesenchymal stromal cells J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-08-26 Sara Romanazzo, Chantal Kopecky, Shouyuan Jiang, Riddhesh Doshi, Vipul Mukund, Pallavi Srivastava, Jelena Rnjak-Kovacina, Kilian Kelly, Kristopher A. Kilian
Mesenchymal stem cell therapy has suffered from wide variability in clinical efficacy, largely due to heterogeneous starting cell populations and large-scale cell death during and after implantation. Optimizing the manufacturing process has led to reproducible cell populations that can be cryopreserved for clinical applications. Nevertheless, ensuring a reproducible cell state that persists after cryopreservation
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Development of a biomimetic bioreactor for regenerative endodontics research J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-08-25 Aurélien Louvrier, Marie Kroemer, Lisa Terranova, Florent Meyer, Marion Tissot, Edouard Euvrard, Florelle Gindraux, Christophe Meyer, Gwenaël Rolin
In the context of regenerative endodontics research with the development of biomaterials, this work aimed to develop and test a prototype biomimetic bioreactor of a human tooth. The bioreactor was designed to reproduce a shaped dental canal connected with a cavity reproducing the periapical region and irrigated through two fluidic channels intended to reproduce the apical residual vascular supply.
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The effect of resolvin D1 on bone regeneration in a rat calvarial defect model J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-08-18 Xiaofeng Jiang, Jing Liu, Si Li, Yingfei Qiu, Xiaoli Wang, Xiaoli He, Torbjørn Ø. Pedersen, Kamal Mustafa, Ying Xue, Manal Mustafa, Alpdogan Kantarci, Zhe Xing
Resolvin D1 (RvD1) is a pro-resolving lipid mediator of inflammation, endogenously synthesized from omega-3 docosahexaenoic acid. The purpose of this study was to investigate the effect of RvD1 on bone regeneration using a rat calvarial defect model. Collagen 3D nanopore scaffold (COL) and Pluronic F127 hydrogel (F127) incorporated with RvD1 (RvD1-COL-F127 group) or COL and F127 (COL-F127 group) were
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Studies on oxygen availability and the creation of natural and artificial oxygen gradients in gelatin-methacryloyl hydrogel 3D cell culture J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-08-13 Carola Schmitz, Iliyana Pepelanova, Christian Ude, Antonina Lavrentieva
Three-dimensional (3D) cultivation platforms allow the creation of cell models, which more closely resemble in vivo-like cell behavior. Therefore, 3D cell culture platforms have started to replace conventional two-dimensional (2D) cultivation techniques in many fields. Besides the advantages of 3D culture, there are also some challenges: cultivation in 3D often results in an inhomogeneous microenvironment
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Clumps of mesenchymal stem cells/extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-08-11 Hisakatsu Sone, Mikihito Kajiya, Katsuhiro Takeda, Shinya Sasaki, Susumu Horikoshi, Souta Motoike, Shin Morimoto, Hiroki Yoshii, Mai Yoshino, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Noriyoshi Mizuno
Periodontitis is an inflammatory disease characterized by tooth-supporting periodontal tissue destruction, including the cementum, periodontal ligament, and alveolar bone. To regenerate the damaged periodontal tissue, mesenchymal stem cells (MSCs) have attracted much scientific and medical attention. Recently, we generated clumps of MSCs/extracellular matrix (ECM) complexes (C-MSCs), which consist
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Issue Information J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-08-05
No abstract is available for this article.
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Erratum J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-08-05
In the article entitled “Minimally invasive treatment of long bone non-unions with bone marrow concentrate, demineralized bone matrix and platelet-rich fibrin in 38 patients” (Cevolani et al., 2021), one of the co-authors’ first name and surname appeared in the wrong order. His name has been corrected as follows: Costantino Errani (Cevolani et al., 2021).
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GMP-grade microcarrier and automated closed industrial scale cell production platform for culture of MSCs J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-08-05 Yuanyuan Zhang, Tao Na, Kehua Zhang, Yanping Yang, Huanye Xu, Lina Wei, Liming Xu, Xiaojun Yan, Wei Liu, Guangyang Liu, Bin Wang, Shufang Meng, Yanan Du
Efficient and large-scale expansion of mesenchymal stem/stromal cells (MSCs) has always been a formidable challenge to researchers in cell-based therapies and regenerative medicine. To reconcile major drawbacks of 2D planar culturing system, we innovatively developed an automated closed industrial scale cell production (ACISCP) platform based on GMP-grade microcarrier for culture of umbilical cord-mesenchymal
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Conditioned medium of amniotic fluid-derived stromal cells exerts a bone anabolic effect by enhancing progenitor population and angiogenesis J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-07-12 Min-Kyoung Song, Hyun Jin Sun, Sun Wook Cho
A cell-free approach utilizing the paracrine effects of mesenchymal stromal cells is receiving attention in regenerative medicine. In the present study, we evaluated the effects of a conditioned medium of amniotic fluid-derived stromal cells (AFSC-CM) on bone metabolism. In mice, intraperitoneal injections of AFSC-CM increased bone mass and enhanced bone turnover. The precursor populations of myeloid
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3D printing of heterogeneous microfibers with multi-hollow structure via microfluidic spinning J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-07-08 Wei Li, Kun Yao, Lingling Tian, Chang Xue, Xu Zhang, Xinghua Gao
Tissues with tubular structures play important roles in the human bodies, such as mass transport, nutrition exchange, and waste filtration. However, it remains a challenge to generate micro-scaffolds with well-defined luminal structure in biomedical field. In this study, we proposed a novel method to fabricate multi-component microfibers with multi-hollow structure via microfluidic spinning, which
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The intra-articular injection of adipose-derived stem cells decreases pain and reduces inflammation in knee osteoarthritis, with or without the addition of platelet-rich plasma also improves functionality J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-07-07 Laynna Carvalho Schweich-Adami, Roberto Antoniolli da Silva, Jovino Nogueira da Silva Menezes, Adrivanio Baranoski, Candida Aparecida Leite Kassuya, Luana Bernardi, Rodrigo Juliano Oliveira, Andréia Conceição Milan Brochado Antoniolli-Silva
The increase of individuals with Osteoarthritis (OA) has generated an increase in public spending in the treatments, which are still not that effective. So, the purpose of this study was to analyze and compare four types of interventions: platelet-rich plasma (PRP), adipose-derived stem cells (ADSCs), ADSCs + PRP and the standard surgical video arthroscopy (All groups passed through standard arthroscopy
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Platelet-rich plasma in the treatment of scars, to suggest or not to suggest? A systematic review and meta-analysis J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-07-06 Zahra Ebrahimi, Yousef Alimohamadi, Majid Janani, Pardis Hejazi, Mahboobeh Kamali, Azadeh Goodarzi
Despite the rising trend for applying platelet-rich plasma (PRP) in the management of various types of scars, there is no convincing evidence supporting its use. This motivated us to review the randomized clinical trials that examine the effectiveness and safety of PRP, alone or in combination with other methods, for the management of atrophic or hypertrophic/keloidal scars. The Web of Science, Scopus
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Issue Information J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-07-01
No abstract is available for this article.
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Modeling the human heart ex vivo—current possibilities and strive for future applications J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-06-24 Ewelina Kałużna, Agnieszka Nadel, Agnieszka Zimna, Natalia Rozwadowska, Tomasz Kolanowski
The high organ specification of the human heart is inversely proportional to its functional recovery after damage. The discovery of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) has accelerated research in human heart regeneration and physiology. Nevertheless, due to the immaturity of iPSC-CMs, they are far from being an representative model of the adult heart physiology. Therefore
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A concise review of the orofacial mesenchymal stromal cells as a novel therapy for neurological diseases and injuries J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-06-18 Zhili Dong, Liping Wu, Lu Zhao
Orofacial mesenchymal stromal cells (OFMSCs) are mesenchymal stromal cells isolated from the oral and facial regions, which possess typical mesenchymal stromal cell features such as self-renewing, multilineage differentiation, and immunoregulatory properties. Recently, increasing studies have been carried out on the neurotrophic and neuroregenerative properties of OFMSCs as well as their potential
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Curcumin slow-release membrane promotes erectile function and penile rehabilitation in a rat model of cavernous nerve injury J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-06-18 Luchen Yang, Zhengju Ren, Zhenghuan Liu, Zhufeng Peng, Pan Song, Jing Zhou, Linchun Wang, Junhao Chen, Qiang Dong
Male erectile dysfunction (ED) caused by cavernous nerve injury is a common complication of pelvic surgery, radiotherapy, transurethral surgery or other operations. However, clinical treatment for iatrogenic or traumatic male ED is difficult and not satisfactory. Many studies have shown that curcumin can promote the repair and regeneration of peripheral nerves; however, whether curcumin can rescue
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Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-06-11 Dimitrios C. Arhontoulis, Charles M. Kerr, Dylan Richards, Kelsey Tjen, Nathaniel Hyams, Jefferey A. Jones, Kristine Deleon-Pennell, Donald Menick, Hanna Bräuninger, Diana Lindner, Dirk Westermann, Ying Mei
Acute cardiac injuries occur in 20%–25% of hospitalized COVID-19 patients. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1β is an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror
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Effects of low-intensity pulsed ultrasound stimulation on cell seeded 3D hybrid scaffold as a novel strategy for meniscus regeneration: An in vitro study J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-06-11 Melika Babaei, Nima Jamshidi, Farshad Amiri, Mohammad Rafienia
Menisci are fibrocartilaginous structures in the knee joint with an inadequate regenerative capacity, which causes low healing potential and further leads to osteoarthritis. Recently, three-dimensional (3D) printing techniques and ultrasound treatment have gained plenty of attention for meniscus tissue engineering. The present study investigates the effectiveness of low-intensity pulsed ultrasound
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Efficient engineering of human auricular cartilage through mesenchymal stem cell chaperoning J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-06-11 Xue Dong, Carly Askinas, Jongkil Kim, John E. Sherman, Lawrence J. Bonassar, Jason Spector
A major challenge to the clinical translation of tissue-engineered ear scaffolds for ear reconstruction is the limited auricular chondrocyte (hAuC) yield available from patients. Starting with a relatively small number of chondrocytes in culture results in dedifferentiation and loss of phenotype with subsequent expansion. To significantly decrease the number of chondrocytes required for human elastic
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Transplantation of encapsulated autologous olfactory ensheathing cell populations expressing chondroitinase for spinal cord injury: A safety and feasibility study in companion dogs J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-06-10 Jon Prager, Joe Fenn, Mark Plested, Leticia Escauriaza, Tracy van der Merwe, Barbora King, Divya Chari, Liang-Fong Wong, Nicolas Granger
Spinal cord injury (SCI) can cause irreversible paralysis, with no regenerative treatment clinically available. Dogs with natural SCI present an established model and can facilitate translation of experimental findings in rodents to people. We conducted a prospective, single arm clinical safety study in companion dogs with chronic SCI to characterize the feasibility of intraspinal transplantation of
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Application of suture anchors for a clinically relevant rat model of rotator cuff tear J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-06-07 Yang Liu, Sai-Chuen Fu, Shi-Yi Yao, Xiao-Dan Chen, Patrick Shu-Hang Yung
Current rat model of rotator cuff (RC) tear could not mimic the suture anchor (SA) repair technique in the clinical practice. We designed a novel SA for RC repair of rats to establish a clinically relevant animal model. Small suture anchors that fit the rat shoulder were assembled. 60 rats were assigned to the transosseous (TO) repair group or SA repair group (n = 30/group). Micro-computed tomography
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Cover Image J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-06-01 Ying Yin, Qiujiao Wang, Chunfeng Xie, Haiyun Chen, Jianliang Jin, Dengshun Miao
The cover image is based on the Research Article Amniotic membrane mesenchymal stem cells-based therapy improves Bmi-1-deficient mandible osteoporosis through stimulating osteoblastic bone formation and inhibiting osteoclastic bone resorption by Ying Yin et al., https://doi.org/10.1002/term.3300.
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Issue Information J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-06-01
No abstract is available for this article.
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Corrigendum J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-06-01
In the article entitled “Biomedical applications of silkworm (Bombyx Mori) proteins in regenerative medicine (a narrative review)” (Khosropanah et al., 2022), the Acknowledgment section has been revised. Below is the revised.
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Hypoxia facilitates proliferation of smooth muscle cells derived from pluripotent stem cells for vascular tissue engineering J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-05-28 Lijun Fang, Jingyi Mei, Boqian Yao, Jiang Liu, Peng Liu, Xichun Wang, Jiahui Zhou, Zhanyi Lin
Tissue-engineered blood vessels (TEBVs) show significant therapeutic potential for replacing diseased blood vessels. Vascular smooth muscle cells (VSMCs) derived from human induced pluripotent stem cells (hiPSCs) via embryoid body (EB)-based differentiation, are promising seed cells to construct TEBVs. However, obtaining sufficient high-quality hiPSC-VSMCs remains challenging. Stem cells are located
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Integrating nonlinear analysis and machine learning for human induced pluripotent stem cell-based drug cardiotoxicity testing J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-05-27 Andrew Kowalczewski, Courtney Sakolish, Plansky Hoang, Xiyuan Liu, Sabir Jacquir, Ivan Rusyn, Zhen Ma
Utilizing recent advances in human induced pluripotent stem cell (hiPSC) technology, nonlinear analysis and machine learning we can create novel tools to evaluate drug-induced cardiotoxicity on human cardiomyocytes. With cardiovascular disease remaining the leading cause of death globally it has become imperative to create effective and modern tools to test the efficacy and toxicity of drugs to combat
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Emerging tissue engineering strategies for the corneal regeneration J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-05-18 Mahsa Fallah Tafti, Hossein Aghamollaei, Mehrdad Moosazadeh Moghaddam, Khosrow Jadidi, Jorge L. Alio, Shahab Faghihi
Cornea as the outermost layer of the eye is at risk of various genetic and environmental diseases that can damage the cornea and impair vision. Corneal transplantation is among the most applicable surgical procedures for repairing the defected tissue. However, the scarcity of healthy tissue donations as well as transplantation failure has remained as the biggest challenges in confront of corneal grafting
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Autologous regeneration of blood vessels in urinary bladder matrices provides early perfusion after transplant to the bladder J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-05-14 Stephanie L. Osborn, Leanna W. Mah, Erica V. Ely, Stefania Ana, Christina Huynh, Naveena S. Ujagar, Serena C. Chan, Philip Hsiao, Jonathan C. Hu, Yvonne Y. Chan, Blaine A. Christiansen, Eric A. Kurzrock
Large animal testing and clinical trials using bioengineered bladder for augmentation have revealed that large grafts fail due to insufficient blood supply. To address this critical issue, an in vivo staged implant strategy was developed and evaluated to create autologous, vascularized bioengineered bladder tissue with potential for clinical translation. Pig bladders were used to create acellular urinary
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Histologic characterization of orbicularis oris muscle with a new acellular dermal matrix grafts in a rabbit model J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-05-07 Lei Song, Xiao Luo, Chialing Tsauo, Bing Shi, Renkai Liu, Chenghao Li
Muscular dysplasia is the key factor in influencing surgical outcomes in patients with cleft lip/palate. In this research, we attempted to evaluate a new acellular dermal matrix (ADM) as a substitute for reconstruction of the orbicularis oris muscle with growth factors such as Insulin-Like Growth Factor I (IGF-I), vascular endothelial growth factor (VEGF) in a rabbit model. 30 male New Zealand Rabbits
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Issue Information J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-05-02
No abstract is available for this article.
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Recent scaffold-based tissue engineering approaches in premature ovarian failure treatment J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-05-05 Tayyebeh Zivari-Ghader, Sanam Dolati, Amir Mehdizadeh, Soodabeh Davaran, Mohammad Reza Rashidi, Mehdi Yousefi
Recently, tissue engineering and regenerative medicine have received significant attention with outstanding advances. The main scope of this technology is to recover the damaged tissues and organs or to maintain and improve their function. One of the essential fields in tissue engineering is scaffold designing and construction, playing an integral role in damaged tissues reconstruction and repair.
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Static magnetic field modulates olfactory ensheathing cell's morphology, division, and migration activities, a biophysical approach to regeneration J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-04-25 Zahra Elyasigorji, Hamid Mobasheri, Luciana Dini
The moderate static magnetic fields (SMFs) have been used here as a non-invasive tool to study their manipulative effects on the olfactory ensheathing cells (OECs) activity, growth, morphology, and migration in culture. The OECs are involved in the regeneration of primary olfactory sensory neurons and migration into the central nervous system to repair axons damaged by infection, injury, etc., that
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Fabrication and evaluation of multifunctional agarose based electrospun scaffolds for cutaneous wound repairs J. Tissue Eng. Regen. Med. (IF 3.3) Pub Date : 2022-04-23 Sachin Latiyan, T. S. Sampath Kumar, Mukesh Doble
Despite several advances in chronic wound management, natural product based scaffolds with high exude absorption and mechanical strength are still a hotspot in the medical field. Thus, present study illustrates the fabrication of agarose (AG; 10% w/v)/polyvinyl alcohol 12% w/v) based multifunctional nanofibrous electrospun scaffolds. Zinc citrate (1%, 3% and 5% w/w of the polymer) was used as a potential