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Interaction of water salinity and titanium dioxide nanoparticle (TiO2) exposure in the Pacific oyster, Crassostrea gigas: immune and antioxidant system responses Toxin Rev. (IF 3.1) Pub Date : 2024-04-03 Sayyed Ali Moezzi, Arash Javanshir Khoei
Titanium dioxide nanoparticles (TiO2) are released into the natural waters in different ways and cause toxicity to aquatic life. Although various studies have reported the toxicity of nanoparticles...
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4-methylimidazole can promote oxidative stress, inflammation and histopathological assessment following sub-chronic exposure in rats: mechanistic approaches Toxin Rev. (IF 3.1) Pub Date : 2024-04-02 Asma Ghasemi, Firouzeh Nazari, Ali Kalantari-Hesari, Mehran Mohseni, Mir-Jamal Hosseini
4-methylimidazole (4-MEI) as the main by-product of many foods like drink colas, beverages, soy sauce, meats, candy, vinegar and caramel color which is formed in a high temperature following millar...
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A comprehensive review of the protective effects of herbals against toxicity of Bisphenol-A Toxin Rev. (IF 3.1) Pub Date : 2024-04-02 Deepti Katiyar, Rashmi Saxena, Abhishek Kumar, Priya Bansal, Surya Prakash, Debaprasad Ghosh, K. Nagarajan
Bisphenol-A (BPA) is a synthetically manufactured phenolic substance that is very widely employed in producing polycarbonate polymers and epoxy resins which further can be found in numerous items o...
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Enhanced biotechnological process for antivenom production using Quality by Design methodology Toxin Rev. (IF 3.1) Pub Date : 2024-04-01 Camila B P da Costa, Rafael Cordeiro e Silva, Lidiane Conceição Rosa, João Ricardo Almeida, Julia Vasconcelos Rodrigues de Assis, Luana Gomes da Silva Ribeiro, Isabelle Mazza Guimarães, Francislene Juliana Martins, Luis Eduardo Ribeiro da Cunha, Rafael Cisne, Helena C Castro
Snakebites envenoming are a global public health problem that largely affects economically vulnerable populations. The primary recognized treatment involves hyperimmune serum, consisting of sterile...
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Reduction and binding of aflatoxin M1 in milk by Lactobacillus plantarum and Lactobacillus brevis isolated from Siahmazgi cheese Toxin Rev. (IF 3.1) Pub Date : 2024-04-01 Mahshid Erfanpoor, Negin Noori, Hassan Gandomi, Asghar Azizian
This study aimed to diagnose the ability of two probiotic strains isolated from Siahmazgi cheese to reduce the concentration of aflatoxin M1 (AFM1), which was able to reduce it up to 50%. Two strai...
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Removal of antibiotics from wastewater via metal-organic frameworks (MOFs) as adsorbents Toxin Rev. (IF 3.1) Pub Date : 2024-03-20 Syed Shoaib Ahmad Shah, Naseem Ahmad Khan, Aziz Ur Rehman, Ghulam Murtaza, Sehra Ashiq, Muhammad Altaf Nazir, Tayyaba Najam, Manzar Sohail
The toxicity of antibiotics in fresh water is an increasing concern of modern society for sustainable life. The elimination of hazardous materials like antibiotics from water is foremost task and f...
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Fluoride intake via watermelon consumption and risk assessment Toxin Rev. (IF 3.1) Pub Date : 2024-03-19 Mahbubeh Tangestani, Sina Dobaradaran, Delaram Abedi, Fatemeh Javanfekr, Azam Mohammadi, Gabriel E. De-La-Torre, Reza Saeedi, Jörg Spitz
Natural fruit beverages are popular drinks worldwide. In particular, watermelon juice is highly consumed in the Middle East because the geographical conditions are suitable for its cultivation. How...
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Mosquitocidal efficacy of niloticin, isolated from Limonia acidissima L. (Rutaceae) against filarial vector Culex quinquefasciatus Say. (Diptera: Culicidae) Toxin Rev. (IF 3.1) Pub Date : 2024-03-14 Appadurai Daniel Reegan, Antony Stalin, Munusamy Rajiv Gandhi, Santiagu Stephen Irudayaraj, Rajakrishnan Rajagopal, Ahmed Alfarhan
Common household mosquitoes are a major public nuisance, and mosquito-borne diseases are the greatest threat to public health. In the current situation, it would be ideal to control mosquito popula...
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Health impacts of endotoxin-particulate matter inhalation, effects beyond cardiopulmonary toxicity Toxin Rev. (IF 3.1) Pub Date : 2024-03-04 Jessica Baldriche-Acosta, Andrea De Vizcaya-Ruiz, Olivier Christophe Barbier, Octavio Gamaliel Aztatzi-Aguilar
Exposure to high levels of particulate matter <2.5 µm (PM2.5) causes cardiorespiratory diseases due to oxidative stress and inflammation. The toxicity of PM2.5 depends on particle size and composit...
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The effects of chlorotoxin and its derivatives on glioma cells: a systematic review of in vitro studies Toxin Rev. (IF 3.1) Pub Date : 2024-02-28 Shahrzad Molavinia, Maryam Salehcheh, Masoumeh Baradaran, Mohammad Ali Karimi, Gholamreza Pirmoradi, Elaheh Mohammadi
Chlorotoxin (CTX), a peptide derived from scorpion venom, is used to detect chloride channels. CTX targets cancer cells like glioblastoma (GBM) via GBM-specific chloride channels. CTX-based uses in...
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Anticancer potential of toxin extracts from vital organs of milk spotted puffer fish Chelonodon patoca on human cancer cell lines Toxin Rev. (IF 3.1) Pub Date : 2024-02-21 Niranjni Sekar, Deepakrajasekar Padmanaban, Vennila Jayaprakash, Rajasekar Valayapathi, Aarthi Azhagudurai, S. Shiva Shakthi Selvakumar, Arulvasu Chinnasamy
Among aquatic creatures, fish are the most diversified organisms that have emerged among other vertebrates. The objective of this research was to evaluate the anticancer properties of toxin extract...
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Toxicity of metal-based nanomaterials in different organisms Toxin Rev. (IF 3.1) Pub Date : 2024-02-15 Guikai Zhu, Peng Zhang, Weichen Zhao, Noman Shakoor, Yi Sun, Qibin Wang, Quanlong Wang, Mingshu Li, Yaqi Jiang, Zhiqiang Tan, Yukui Rui, Iseult Lynch
Metal-based nanomaterials (MNMs) possess exceptional properties that have led to their widespread use in various fields, including medicine, energy, electronics, and agriculture. However, this incr...
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Potential of Melittin to induce apoptosis and overcome multidrug resistance in human colon cancer cell line Toxin Rev. (IF 3.1) Pub Date : 2024-02-15 Danijela D. Nikodijević, Jovana V. Jovankić, Nikola M. Radenković, Danijela M. Cvetković, Ana M. Podolski-Renić, Milena G. Milutinović
In this study, the anticancer effect of Melittin was demonstrated through its antiproliferative and proapoptotic effects on HT-29 cells, as well as its ability to reverse multidrug resistance. Meli...
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Application of nanotechnology in removing laboratory contaminants from the environment Toxin Rev. (IF 3.1) Pub Date : 2024-02-12 Negar Karimi Hajishore, Elham Abbasi, Milad Shirvaliloo, Ramin Rasouli, Mohammad Mohammad Najjar, Abolfazl Akbarzadeh, Roghayeh Sheervalilou, Amir Nezami Asl
Every year, lots of hazardous chemicals are emitted into the environment; therefore, environmental pollution is a big concern for all communities in the world. The consequential effects of laborato...
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Hydra as a research model Toxin Rev. (IF 3.1) Pub Date : 2024-01-30 Javeria Fatima, Gulshan Ara, Mohammad Afzal, Yasir Hasan Siddique
Hydra, a member of the Phylum Cnidaria, has emerged as a versatile and valuable model organism for various scientific studies. Its remarkable regenerative capacity and perpetual reproductive capabi...
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Correction Toxin Rev. (IF 3.1) Pub Date : 2024-01-17
Published in Toxin Reviews (Vol. 43, No. 1, 2024)
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Insights into the role of melatonin on the reproductive system toxicity induced by bisphenol A: a systematic review of preclinical studies Toxin Rev. (IF 3.1) Pub Date : 2024-01-13 Behnaz Bameri, Maryam Armandeh, Hamed Haghi-Aminjan, Mahban Rahimifard, Shokoufeh Hassani, Mahdi Gholami, Mahshid Ataei, Mahedeh Samadi, Marzieh Daniali, Mohammad Reza Hooshangi Shayesteh, Mohammad Abdollahi
Bisphenol A (BPA), an endocrine disruptor, changes many physiological functions of the body, especially the reproductive system. The malfunction of the reproductive system after BPA exposure is one...
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Evaluation of copper nanoparticles on growth, organs histology and DNA damage in Japanese quails (Coturnix coturnix japonica) Toxin Rev. (IF 3.1) Pub Date : 2024-01-08 Shabana Naz, Naveed Raza, Ibrahim Alhidary, Sania Satti, Azhar Rafique, Sajida Batool, Shamsuddin Shamsi, Dai Sifa, Rifat Ullah Khan
The effects of Copper oxide nanoparticles (CuO-NPs) have been investigated on human cells and various experimental animals. However, there is a lack of research on the effects of CuO-NPs specifical...
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The effect of ascorbic acid and lemon juice on the extraction of metals from green tea, health risk assessment Toxin Rev. (IF 3.1) Pub Date : 2024-01-02 Melisa Begić, Jasna Huremović, Alisa Selović, Amar Karadža
The total heavy metal concentration (Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Zn) in green tea leaves and metals leached into tea infusions of pure water with the addition of ascorbic acid and lemon juice a...
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In-vitro and in-silico analysis of methanolic crude extracts of Mountain knotgrass Aerva lanta (L.) against two lepidopteran pests and non-target species Toxin Rev. (IF 3.1) Pub Date : 2023-12-22 Karthick Kalvikkarasan, Janaki Muthusamy, Vasantha-Srinivasan Prabhakaran, Raghuraman Pandiyan, Radhakrishnan Narayanaswamy, Kannan Muthu, Karthi Sengodan, Ganesan Raja, Senthil-Nathan Sengottayan, Ganesh-Kumar Selvaraj, Rajagopal Rajakrishnan, Han Yeon Soo
The present research investigates the toxicological screening of crude methanol extracts Avera lanata (Mx-Al) traditionally used for its medicinal properties, and explored its potential as an insec...
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The protective effects of betanin on titanium dioxide (TiO2) nanoparticle exposure in rats Toxin Rev. (IF 3.1) Pub Date : 2023-12-18 Serdal Ogut, Serdar Aktas, Mehmet Fatih Bozkurt, Serap Unubol Aypak, Rabia Berber
The aim of this study was to investigate the protective properties of betanin in rats exposed to Titanium dioxide (TiO2) nanoparticles. An experimental animal study was conducted on 40 Spraque Dawl...
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Oxidative stress induction by OCPs and OPPs pesticides may cause lung cancer incidence Toxin Rev. (IF 3.1) Pub Date : 2023-12-03 Gholamreza Asadikaram, Hossein Pourghadamyari, Moslem Abolhassani, Mojtaba Abbasi-Jorjandi, Sanaz Faramarz, Fatemeh Yousefi, Fouzieh Salimi, Reza Malekpour Afshar, Parisa Asadikaram, Mohsen Shafiepour
Pesticides are nowadays known as one of the most important causes of human disorders worldwide. The aim of the present study was to investigate the role of organochlorine pesticides (OCPs) and orga...
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The role of probiotics in improving food safety; detoxification of heavy metals and chemicals Toxin Rev. (IF 3.1) Pub Date : 2023-11-22 Fereshteh Ansari, Chi-Ching Lee, Azadeh Rashidimehr, Soheyl Eskandari, Tolulope Joshua Ashaolu, Esmaeel Mirzakhani, Hadi Pourjafar, Seid Mahdi Jafari
Various studies have shown that different types of probiotics as healthy gut microbes, in addition to having beneficial effects on the host’s health, have an excellent ability to eliminate and neut...
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Advances in rapid and sensitive biosensors for AF detection: toward enhanced food safety Toxin Rev. (IF 3.1) Pub Date : 2023-11-19 Bircan Dinc, Neslihan Demirci, Recep Üstünsoy, Tahsin Ertaş
AFs are among the most dangerous compounds, exhibiting carcinogenic effects on human and liver tissue. Due to their high toxicity and established limits in food and feed products, there is a growin...
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Evaluation of neuroprotective and anti-amnesic effects of the chloroform fraction of Nigella sativa L. on scopolamine-induced memory impairment in rats Toxin Rev. (IF 3.1) Pub Date : 2023-11-10 Somayyeh Karami-Mohajeri, Hamideh Bashiri, Elham Jafari, Neda Mohamadi, Mahya Shahriari, Ali Hashemian, Fariba Sharififar
The aim of this study was to investigate the neuroprotective and anti-amnesic effects of total extract (NTE) and chloroform fraction of Nigella sativa (NCE) on scopolamine (SCO)-induced memory impa...
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Ocular sequelae of snakebite envenoming: a review of the indirect effects of snakebite envenoming on the eye Toxin Rev. (IF 3.1) Pub Date : 2023-11-06 Maarten B. Jalink, Jory van Thiel, Roel M. Wouters, Freek J. Vonk, Robert P.L. Wisse
Snakebite envenoming is a major public health issue in developing, often agricultural-based, tropical countries, which causes substantial mortality and morbidity. Most studies have been conducted o...
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Detection of heavy metals using atomic absorption and emission spectroscopy in drinking water of Faisalabad, Pakistan: microbial safety and quality status assessment Toxin Rev. (IF 3.1) Pub Date : 2023-10-30 Saba Anwar, Qamar Abbas Syed, Asad Ullah, Mehwish Arshad, Shahbaz Nasir Khan, Muhammad Iftikhar Hussain
Synthetic dyes from textile industries are designated as hazardous waste since they release heavy metals and dangerous contaminants in water that harm the environment and human health. The current ...
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Source, ecological function, toxicity and resistance of Tetrodotoxin (TTX) in TTX-bearing organisms: a comprehensive review Toxin Rev. (IF 3.1) Pub Date : 2023-09-07 Ying Zhang, Shanmei Zou, Shaowu Yin, Tao Wang
Tetrodotoxin (TTX) can be dangerous to food security or even cause death. But TTX also has beneficial values, for example in clinical applications and drug discovery, it is used to treat arthritis,...
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Risk assessment of potentially toxic elements in agricultural soils and bioconcentration in rice grains from Faridkot District, India Toxin Rev. (IF 3.1) Pub Date : 2023-09-01 Inderpreet Kaur, Arashdeep Kaur, Sakshi Sharma
Potentially toxic elements (PTEs) in soil pose significant risks to both ecology and human health. Therefore, to understand the effect of PTEs in agricultural soils of Faridkot District, Punjab, In...
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Geochemical and environmental assessment of river sediments in the East of Gilan province (case study: Otaghvarrud, Shalmanrud, and Polrud rivers), Northern Iran Toxin Rev. (IF 3.1) Pub Date : 2023-08-14 F. Asghari, M. Salavati, S. Hakimi Asiabar, F. Shariati
In this study, the pollution of heavy metals in the sediments of the Otaghvarrud, Shalmanrud, and Polrud rivers was assessed to determine the geochemical and environmental contamination. Samples we...
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High-efficient photocatalytic degradation of tamoxifen and doxorubicin by novel ternary heterogeneous GO@Fe3O4@CeO2 photocatalyst Toxin Rev. (IF 3.1) Pub Date : 2023-08-09 Nahid Rashtchi, Soheil Sobhanardakani, Mehrdad Cheraghi, Amirreza Goodarzi, Bahareh Lorestani
Pharmaceuticals are a new class of water contaminants that need to be effectively removed. This study combines GO@Fe3O4 with CeO2 nanoparticles via a simple procedure known as heterogeneous visible...
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Human health risks in Ferozepur District, Punjab, India due to potentially toxic elements in agricultural soils Toxin Rev. (IF 3.1) Pub Date : 2023-05-25 Inderpreet Kaur, Harpreet Kaur Dhillon, Sakshi Sharma
Abstract In the present study, soil contamination by arsenic, cadmium, chromium, cobalt, copper, iron, lead, manganese, nickel, uranium and zinc; and associated human health risks were assessed at 30 agricultural sites in Ferozepur District, Punjab. Above 90% soil samples had high content of chloride, sodium and potassium. Cadmium, arsenic, zinc and lead in 100%, 76.67%, 76.67% and 66.67% samples exceeded
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Evaluation of blood BTEX levels in fuel stations workers using vortex-assisted dispersive liquid-liquid microextraction based on deep eutectic solvent followed by gas chromatography flame-ionization detector Toxin Rev. (IF 3.1) Pub Date : 2023-05-24 Mari Ataee, Toraj Ahmadi Jouybari, Hawre Lateef Ahmed, Hadi Ahmadi Jouybari, Meghdad Pirsaheb, Nazir Fattahi
Abstract In this research, an eco-friendly method was established by vortex-assisted dispersive liquid-liquid microextraction based on the deep eutectic solvent (VA–DLLME–DES). The performance of the proposed method was demonstrated by the determination of benzene, toluene, ethylbenzene, and xylene (BTEX) in blood samples of fuel stations workers combined with GC–FID. The selected hydrophilic deep
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Influence of various operational parameters on the photocatalytic degradation of ciprofloxacin in aqueous media: a short review Toxin Rev. (IF 3.1) Pub Date : 2023-05-19 Saifullahi Shehu Imam, Rohana Adnan, Noor Haida Mohd Kaus, Najm Us Saqib
Abstract Ciprofloxacin (CIP) is a frequently prescribed antibiotic for various medicinal purposes that have been detected in surface water, wastewater, and wastewater treatment plants. It is a persistent organic pollutant due to its halogenated heterocyclic structure and high chemical stability at a wide range of pH. The presence of CIP in wastewater treatment plants is an indication that the antibiotic
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Application of crosslinked chitosan-nanoclay composite beads for efficient removal of Ponceau S azo dye from aqueous medium Toxin Rev. (IF 3.1) Pub Date : 2023-05-11 Seda Çınar, Ayşe Dinçer, Ahmet Eser, Tülin Aydemir
Abstract In this study, chitosan-nanoclay composite beads (CS/NC composite beads) were used to remove Ponceau S from aqueous solutions. CS/NC composites characterization was performed with FTIR, SEM-EDX, TGA, BET and XRD analyzes. The adsorption procedure was optimized by changing various parameters in batch experiments such as pH, dye concentration, contact time and temperature. Ponceau S adsorption
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Inhibition of phospholipase A2 from Naja haje and Naja nigricollis venoms by active fraction of Moringa oleifera leaves: in vitro and in silico methods Toxin Rev. (IF 3.1) Pub Date : 2023-05-03 Akindele Oluwatosin Adeyi, Abideen Omobayo Jimoh, Babafemi Siji Ajisebiola, Olubisi Esther Adeyi, Damilohun Samuel Metibemu, Raphael Emuebie Okonji
Abstract Phospholipases are one of the principal toxic enzymes in snake venoms inducing a wide variety of pharmacological effects after envenomation. Natural inhibitors from plants are known to inhibit the toxic enzyme activities of snake venoms. In this study, ethanol crude extract of M. oleifera leaves was partitioned using n-hexane and ethyl acetate after which fractionation was done using column
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A systematic review of the bioprospecting potential of Lonomia spp. (Lepidoptera: Saturniidae) Toxin Rev. (IF 3.1) Pub Date : 2023-05-02 Henrique G. Riva, Angela R. Amarillo-S.
Abstract Toxins from venomous animals are proteins used for their defense or to hunt. Lonomia (Lepidoptera: Saturniidae) caterpillars can be lethal, and accidental inoculation of the venom from its bristles into human skin causes systemic blood coagulation disorders. Several reviews have investigated the pathophysiology of lonomic poisoning; however, considering the potential of venoms for bioprospecting
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Modulating insulin secretion and inflammation against sodium arsenite toxicity by levosimendan as a novel pancreatic islets’ protector Toxin Rev. (IF 3.1) Pub Date : 2023-04-27 Marzieh Daniali, Mona Navaei-Nigjeh, Maryam Baeeri, Soheyl Mirzababaei, Mahdi Gholami, Mahban Rahimifard, Mohammad Abdollahi
Abstract Levosimendan (LEVO) is a calcium sensitizer with established inotropic and vasodilator impacts associated with ATP-sensitive potassium channels (KATP). Although LEVO’s role in modulating oxidative stress of cardiac cells has been studied, in the current study, LEVO was used, for the first time, to investigate its preventive and therapeutic roles in pancreatic islets through viability, functionality
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Dose- and dosage-dependent spectrum of respiratory toxicity of cypermethrin in rabbits Toxin Rev. (IF 3.1) Pub Date : 2023-04-27 Latif Ahmad, Shafia Tahseen Gul, Xiaoxia Du, Riaz Hussain, Muhammad Rafiq Khanani, Shajeela Iram, Aziz Ur Rehman, Ahrar Khan
Abstract Pyrethroids are popular insecticides. Shortness of breath and dyspnea are key signs of exposure; however, their respiratory effects are rarely studied. This study investigated the combination and ratios of specific blood tests and lung lesions as respiratory effects of cypermethrin (CY) in rabbits. The effects of CY at various doses and times are the novelty of this study. Doses (50, 100,
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Melatonin pretreatment can improve the therapeutic effect of adipose-derived stem cells on CCl4-induced liver fibrosis Toxin Rev. (IF 3.1) Pub Date : 2023-03-28 Ziqiang Zhang, Yingying Sun, Haojie Wang, Yuxiang Yang, Ruiqi Dong, Yaolu Xu, Mengyu Zhang, Qiongxia Lv, Xiaoguang Chen, Yumei Liu
Abstract In this study, the therapeutic effect of Mel-incubated Adipose-derived mesenchymal stem cells (ADSCs) on CCl4-induced hepatic fibrosis was investigated. Mice with hepatic fibrosis were intraperitoneally injected with 8% CCl4 twice a week for 4 weeks. Starting from week 5, mice in the ADSC group and ADSC + Mel group were injected with 1 mL PBS cell suspension containing 1 × 106 ADSCs or ADSCs
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Phytochemical composition, toxicity, and repellent effects of medicinal plants Peganum harmala, Pterocarya fraxinifolia, and Tanacetum parthenium extracts against Sitophilus oryzae L. Toxin Rev. (IF 3.1) Pub Date : 2023-02-16 Mahmoud Fazeli-Dinan, Seyed Hanif Osia-Laghab, Mina Amini, Ali Davoodi, Seyed Hassan Nikookar, Jamshid Yazdani Charati, Mohammad Azadbakht, Ahmadali Enayati
Abstract Sitophilus oryzae is an important pest of stored rice and is usually controlled by the use of aluminum phosphide, which is dangerous to humans. Botanical insecticides deemed promising alternatives in controlling this pest. In this study, extracts of Peganum harmala seeds, Pterocarya fraxinifolia leaves, and Tanacetum parthenium flowers were evaluated against S. oryzae adults. Phytochemical
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Medicago sativa ameliorated cyclophosphamide-induced thrombocytopenia and oxidative stress in rats Toxin Rev. (IF 3.1) Pub Date : 2023-02-14 Zahra Gholamnezhad, Vajihe Rouki, Ramin Rezaee, Mohammad Hossein Boskabady
Abstract Effect of Medicago sativa (MS) hydro-ethanolic extract against the cyclophosphamide (CP)-induced toxicity was evaluated in rats grouped as: Control; CP (100 mg/kg subcutaneous, day 1–3); and CP+ MS100, 200, and 400 mg/kg/day, orally for 14 days. Hematologic, lipid, hepatic and oxidative stress markers were analyzed. Platelet, WBC, RBC, Hb and Hct in the CP group were lower than the control
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Epidemiologic and spatiotemporal study on access to snakebite care in Northern Nigeria Toxin Rev. (IF 3.1) Pub Date : 2023-02-11 Naziru Halliru, Murtala M. Badamasi, Ibrahim Y. Tudunwada, Titus B. Dajel, Saidu B. Abubakar, Auwalu S. Hamza, Sandra B. Oluwashola, Nasiru K. Nalado, Muhammad Dahiru, Ibrahim Na’abdu, Umar N. Saleh, Abdulhakim M. Daiyab, Suleman A. Mohammed, Garba Iliyasu, Hamza Muhammad, Abdulrazaq G. Habib
Abstract The role of epidemiologic and spatiotemporal factors affecting access to care among snakebite patients in Nigeria are determined. In 2021 a total of 2,942 snakebite patients were prospectively studied at four designated Health Facilities for Managing Snakebites (HFMS). The patients came from 94 Local Government Areas (LGAs) in 12 states in northern Nigeria. It was found that 435 (14.8%) patients
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Gallic acid and sesame oil exert cardioprotection via mitochondrial protection and antioxidant properties on Ketamine-Induced cardiotoxicity model in rats Toxin Rev. (IF 3.1) Pub Date : 2023-01-13 Ahmad Salimi, Mohammad Shabani, Deniz Bayrami, Armin Saray, Nastaran Farshbaf Moghimi
Abstract Ketamine is a cardiotoxic agent and can deplete ATP in cardiomyocytes through mitochondrial dysfunction. We investigated the effects of gallic acid and sesame oil in ketamine-induced cardiotoxicity in rats. Male Wistar rats were randomly divided into six groups including control; ketamine; ketamine + gallic acid; ketamine + sesame oil; gallic acid and sesame oil. Serum cardiac marker, cardiac
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The content of ten elements in pig feed and manure and its relationship with element concentration in earthworms on swine farms Toxin Rev. (IF 3.1) Pub Date : 2023-01-12 Branislava M. Mitrović, Srđan Stefanović, Dragan Šefer, Dragoljub Jovanović, Jelena Ajtić
Abstract The aim of this investigation is to determine the content of ten elements, Cr, Mn, Co, Ni, Fe, Zn, As, Cu, Se, and Cd, in pig feed, manure and earthworms (Lumbricus terrestris). Samples were collected during 2015 and 2017, on four pig farms in Serbia, and analyzed for elements by inductively coupled plasma mass spectrometry. According to the mean concentrations, the elements show the following
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DNA breaks evaluation of two water-based metalworking fluids by an occupational exposure design Toxin Rev. (IF 3.1) Pub Date : 2023-01-05 Zahra Moradpour, Parviz Abdolmaleki, Behnam Hajipour-Verdom, Ali Khavanin, Zahra Panjali, Nader Maghsudi, Mansoureh Hamidi, Rezvan Zendehdel
Abstract Thermal degradation of water-based metalworking fluids (MWFs) produces carcinogen by-products. Since different additives have been used to eliminate hazardous material, the carcinogenic potential of two water-based MWFs was investigated in the lung epithelial cell line (A549). Two MWF types were studied in pure and on-used. The chemical content of all samples was assessed by gas chromatography–mass
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Antimicrobial activity of flavonoids glycosides and pyrrolizidine alkaloids from propolis of Scaptotrigona aff. postica Toxin Rev. (IF 3.1) Pub Date : 2022-12-16 T. M. Cantero, P. I. Silva Junior, G. Negri, R. M. Nascimento, R. Z. Mendonça
Abstract Stingless bees, or simply meliponines, are a large group of bees (about 550 described species), comprising the tribe Meliponini. They belong in the family Apidae, and are closely related to Apis mellifera. Scaptotrigona affinis postica Latreille, 1807 from northeast of Brazil is popularly known as “tubi” in Maranhão State. Flavones di-C-glycosides, and the pyrrolizidine alkaloid 3-methoxy
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Streptozotocin mechanisms and its role in rodent models for Alzheimer’s disease Toxin Rev. (IF 3.1) Pub Date : 2022-12-05 Mazzura Wan Chik, Nur Adiilah Ramli, Nurul Aqmar Mohamad Nor Hazalin, Gurmeet Kaur Surindar Singh
Abstract The majority of dementia is caused by Alzheimer’s disease (AD) that manifests in the familial and sporadic forms. The latter accounts for the most of the cases and is a complex multi-factorial disorder with no cure. Despite the vast growth of animal models, both the transgenic and non-transgenic therapeutic findings for AD seem ambiguous. Streptozotocin (STZ) administration is the most accepted
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Toxic uranium contamination in groundwater of Thoothukudi district, India: Evaluation of health risks using the geochemical and statistical approach Toxin Rev. (IF 3.1) Pub Date : 2022-11-30 Velayutham Raja, Mallanpillai Ananthakrishnan Neelakantan
Abstract The present investigation aims to determine the health risks of toxic uranium contamination in the drinking water of the Thoothukudi district. Two hundred and eighty-six samples were examined during the pre- and post-monsoon seasons and found the uranium concentration ranges from <0.2 to 167 ppb (mean 12, Standard deviation 21) (pre-monsoon) and <02 to 190 ppb (mean 13, Standard deviation
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Human health risk and hydro-geochemical appraisal of groundwater in the southwest part of Bangladesh using GIS, water quality indices, and multivariate statistical approaches Toxin Rev. (IF 3.1) Pub Date : 2022-10-19 Tapos Kumar Chakraborty, Md. Shahnul Islam, Gopal Chandra Ghosh, Prianka Ghosh, Samina Zaman, Ahsan Habib, Md. Ripon Hossain, Himel Bosu, Md. Rashidul Islam, Mostafa Al Imran, Abu Shamim Khan, Md. Shahariea Karim Josy
Abstract This study investigated the groundwater chemistry, suitability, and potential human health risk in the southwest part of Bangladesh. Groundwater samples were collected from the shallow aquifer throughout the study area. A set of different hydro-chemical analyses, water quality indices, multivariate statistics, and geo-statistical models were applied to achieve the study objectives. Study results
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Mitochondrial biogenesis alteration in arsenic-induced carcinogenesis and its therapeutic interventions Toxin Rev. (IF 3.1) Pub Date : 2022-10-03 Kshirod Bihari Sathua, Rakesh Kumar Singh
Abstract Arsenic poisoning is one of the major devastation and horrific concerns across the globe. Its concentration in the environment is continuously increasing over time, and hence it may play a role of exterminator for the future civilization. Cancer is the one of the main detrimental outcomes of arsenic poisoning. The International Agency for Research on Cancer suggested arsenic as a class-1 carcinogen
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Production of hyperimmune sera: a study of digestion and fractionation methodologies for the purification process of heterologous immunoglobulins Toxin Rev. (IF 3.1) Pub Date : 2022-09-20 Camila Braz Pereira da Costa, Vanessa Ramos de Carvalho, Leide Lene Coelho Ferreira, Jorge Luiz Coelho Mattos, Leila de Mendonça Garcia, Marcia de Souza Antunes, Francislene Juliana Martins, Norman A. Ratcliffe, Rafael Cisne, Helena C. Castro
Abstract Several scientific studies to evaluate the process of digestion and fractionation of immunoglobulins have been carried out in order to improve the production of hyperimmune sera. Today, quality, safety, and production efficiency, along with the development of optimized, robust, and cost-effective processes are priorities. Thus, this work analyzed previous studies of enzymatic digestion of
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Review of mechanisms of genotoxic action of dibenzo[def,p]chrysene (formerly dibenzo[a,l]pyrene) Toxin Rev. (IF 3.1) Pub Date : 2022-09-20 K. Kowalczyk, J. Roszak, Z. Sobańska, M. Stępnik
Abstract Polycyclic aromatic hydrocarbons (PAHs) are a large group of organic compounds that have always been present in the environment. With the technological and civilization development, exposure to this class of compounds has considerably increased. Dibenzo[def,p]chrysene (DBC), formerly known as dibenzo[a,l]pyrene, is one of the most important and probably the most carcinogenic among all PAHs
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Preparation of AC/KOH and AC/Fe3O4/ZnO nanocomposite from waste rice straw for the removal of cyclophosphamide from aqueous solutions Toxin Rev. (IF 3.1) Pub Date : 2022-09-19 Ali Asghar Haghgoo, Mehrdad Cheraghi, Soheil Sobhanardakani, Bahareh Lorestani, Vida Izadkhah
Abstract In this study, rice straw was used for synthesizing AC/KOH and AC/Fe3O4/ZnO as fresh adsorbents for the elimination of Cyclophosphamide (CP) from water samples. In so doing, the crystalline form, the chemical compound and the morphology of the adsorbents were characterized utilizing scanning electron microscopy (SEM), X-ray diffraction (XRD) spectrometry, Fourier transform infrared spectroscopy
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Female infertility caused by organophosphates: an insight into the latest biochemical and histomorphological findings Toxin Rev. (IF 3.1) Pub Date : 2022-09-09 Mohammad Samare-Najaf, Ali Samareh, Bahia Namavar Jahromi, Navid Jamali, Sina Vakili, Majid Mohsenizadeh, Cain C. T. Clark, Ali Abbasi, Nastaran Khajehyar
Abstract The etiology of female infertility includes a variety of causes, all of which could be induced by environmental pollutants. Organophosphates (OPs) are major constituents of pollutants that cause infertility in aquatic and terrestrial organisms. However, no study has comprehensively reviewed the female fertility-related consequences of exposure to OPs. In this study, the reviewed studies revealed
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Effect of bacterial toxin identified from the Bacillus subtilis against the Cnaphalocrocis medinalis Guenée (Lepidoptera: Crambidae) Toxin Rev. (IF 3.1) Pub Date : 2022-09-02 Ramakrishnan Ramasubramanian, Sengodan Karthi, Sengottayan Senthil-Nathan, Haridoss Sivanesh, Narayanan Shyam Sundar, Vethamonickam Stanley-Raja, Govindaraju Ramkumar, Kanagaraj Muthu-Pandian Chanthini, Prabhakaran Vasantha-Srinivasan, Khaloud Mohammed Alarjani, Mohamed S Elshikh, Ahmed Abdel-Megeed, Patcharin Krutmuang
Abstract In recent times, controlling agricultural diseases and pests using chemical pesticides is broadly applied and is considered effective but it is not considered as eco-friendly. For pest control, biological ways have been considered sustainable and safe. As bio-control agents, the Bacillus species exhibit a large spectrum of biological activity. The application of Bacillus subtilis as a potential
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Retraction statement: Enhancement of the antifungal properties of Zataria multiflora essential oil through nanoencapsulation with ZnO nanomaterial Toxin Rev. (IF 3.1) Pub Date : 2022-08-12
Published in Toxin Reviews (Vol. 41, No. 3, 2022)
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Phthalates in commonly used pharmaceuticals Toxin Rev. (IF 3.1) Pub Date : 2022-06-30 Şana Sungur, Mutasım Ciran, Muaz Köroğlu, F. Hilmi Turgut
Abstract Phthalates are man-made, endocrine disrupting chemicals that are commonly used in plastics, medical applications, drugs, personal care products, cosmetics, perfumes, home furnishings, dyes, children’s toys, food packaging. Animal studies have revealed that phthalates have many adverse health effects. Since phthalates do not dissolve in acidic environments, they are only soluble in neutral
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Snake venom toxins targeting the central nervous system Toxin Rev. (IF 3.1) Pub Date : 2022-06-23 Amit Talukdar, Priya Maddhesiya, Nima Dondu Namsa, Robin Doley
Abstract Snake venom is a blend of bioactive proteins, polypeptides, and various other substances with toxic and lethal properties that are known to modulate varied physiological and biological systems. During envenomation, venom toxins primarily target the hemostatic and nervous system for effective immobilization or death of the prey. The central (CNS) and the peripheral nervous system (PNS) are
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Identification, characterization, and molecular phylogeny of scorpion enolase (Androctonus crassicauda and Hemiscorpius lepturus) Toxin Rev. (IF 3.1) Pub Date : 2022-06-08 Elham Pondehnezhadan, Atefeh Chamani, Fatemeh Salabi, Reihaneh Soleimani
Abstract Scorpions are the oldest terrestrial fauna with an ancient evolutionary history. To study the origins of scorpions, we conducted a molecular phylogenetic study of the arthropod using slowly evolving enolase sequences. In this study, we used deep RNA-seq technology to identify the enolase sequences of Androctonus crassicauda and Hemiscorpius lepturus scorpions. The scorpion’s enolase sequences