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Essential oil supplementation in milk replacers: short- and long-term impacts on feed efficiency, the faecal microbiota and the plasma metabolome in dairy calves J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-04-02 Sonia Andrés, Chiara Gini, Fabrizio Ceciliani, Daniel Gutiérrez-Expósito, Noive Arteche-Villasol, Alba Martín, Paola Cremonesi, Fiorenza Faré, Morteza Hosseini Ghaffari, F. Javier Giráldez, Latifa Abdennebi-Najar
Early supplementation with oregano essential oil (EO) in milk replacer (MR) may improve growth, immune responses, the microbiota and the metabolome in dairy calves during pre-weaning and in adulthood. Sixteen female dairy calves (3 days of age) were divided in two groups (n = 8/group): the control group (no EO) and the EO group (0.23 ml of EO in MR during 45 days). After weaning, calves were kept in
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(-)-epicatechin treatment did not modify the thermogenic pathway in the gastrocnemius muscle of male rat offspring obeses by programming J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-03-19 María Elena Tejeda, Sergio De los Santos, Ramón Mauricio Coral-Vázquez, Ana Álvarez-Chávez, Carlos Palma Flores, Elena Zambrano, Juan Pablo Méndez, Patricia Canto
The aim of this study was to analyse the expression of genes related to the regulation of energy metabolism in skeletal muscle tissue by comparing male offspring in two age groups [at 110 and 245 postnatal days (pnd)] from a mother with obesity induced by a high-fat diet and (-)-epicatechin (Epi) administration. Four groups of six male offspring from different litters were randomly selected for the
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Breastfeeding moderates the association of maternal pre-pregnancy nutritional status with offspring body composition at 30 years J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-03-15 Bernardo L. Horta, Kelly P. Coca, Mina Desai, Mariane S. Dias, Manoella B. Jaccottet, Michael G. Ross
Maternal pre-pregnancy body mass index is positively associated with offspring obesity, even at adulthood, whereas breastfeeding decreases the risk of obesity. The present study was aimed at assessing whether breastfeeding moderates the association of maternal pre-pregnancy body mass index with offspring body composition at adulthood, using data from 3439 subjects enrolled in a southern Brazilian birth
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Anaesthesia and brain development: a review of propofol-induced neurotoxicity in pediatric populations J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-03-07 Weixin Zhang, Qi Liu, Junli Wang, Li Liu
With the advancement of medical technology, there are increasing opportunities for new-borns, infants, and pregnant women to be exposed to general anaesthesia. Propofol is commonly used for the induction of anaesthesia, maintenance of general intravenous anaesthesia and sedation of intensive-care children. Many previous studies have found that propofol has organ-protective effects, but growing evidence
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The developmental origins of health and disease and intergenerational inheritance: a scoping review of multigenerational cohort studies J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-03-07 Jie Tan, Zifang Zhang, Lijing L. Yan, Xiaolin Xu
Epidemiologic research has increasingly acknowledged the importance of developmental origins of health and disease (DOHaD) and suggests that prior exposures can be transferred across generations. Multigenerational cohorts are crucial to verify the intergenerational inheritance among human subjects. We carried out this scoping review aims to summarize multigenerational cohort studies’ characteristics
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Supplementation of the maternal diet with Brazil nut (Bertholletia excelsa H.B.K.) prevents cognitive impairment in the offspring of obese mothers J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-02-12 Lilian Fioravanso Apolinário, Amanda Tais Silva, Andrielli Pompermayer Rosa, Cleber da Silva Oliveira, Cleberson Lira, João Pedro Costa dos Santos Guerra, Júlia Furtado Friedrich, Letícia Queiroz Rosa, Rodrigo Chelegão, Sílvia de Carvalho Campos Botelho, Valéria Dornelles Gindri Sinhorin, Júlio Cezar de Oliveira, Nádia Aléssio Velloso
Maternal obesity may trigger long-term neurodevelopmental disorders in offspring. Considering the benefits of the Brazil nut (Bertholletia excelsa H.B.K.), a rich source of nutrients such as selenium, this study aimed to evaluate its effect on the behavior of obese rat offspring and its relationship with oxidative stress. From 60 days of age until weaning, female Wistar rats were fed a high-fat diet
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Maternal prenatal and postnatal psychological distress trajectories and impact on cognitive development in 4-year-old children: the Japan Environment and Children’s Study J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-02-08 Hidekazu Nishigori, Toshie Nishigori, Taeko Suzuki, Miyuki Mori, Mika Yamada, Hirotaka Isogami, Tsuyoshi Murata, Hyo Kyozuka, Yuka Ogata, Akiko Sato, Hirohito Metoki, Kosei Shinoki, Seiji Yasumura, Mitsuaki Hosoya, Koichi Hashimoto, Keiya Fujimori, the Japan Environment and Children’s Study Group
Maternal prenatal and postnatal psychological distress, including depression and anxiety, may affect children’s cognitive development. However, the findings have been inconsistent. We aimed to use the dataset from the Japan Environment and Children’s Study, a nationwide prospective birth cohort study, to examine this association. We evaluated the relationship between the maternal six-item version of
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Association between vitamin levels and obesity in the national health and nutrition examination surveys 2017 to 2018 J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-01-23 Xiaomin Lu, Zhongyou Sun
In recent years, the rapidly increasing incidence of obesity is becoming a worldwide public health problem. Obesity is a chronic disease which may have a major negative effect on the people’s quality of life. Previous studies on the comprehensive effects of multivitamins on central obesity and general obesity are relatively few. The aim of this study was to evaluate association of vitamins exposure
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Human milk polyunsaturated fatty acids are related to neurodevelopmental, anthropometric, and allergic outcomes in early life: a systematic review J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-01-23 Saori Mitguard, Olivia Doucette, John Miklavcic
Polyunsaturated fatty acids are critically important for newborn nutrition and in the trajectory of growth and developmental processes throughout early life. This systematic review (PROSPERO ID: CRD42023400059) critically analyzes literature pertaining to how omega-3 and omega-6 fatty acids in human milk are related to health outcomes in early life. Literature selected for the review were published
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A systematic review exploring evidence for adolescent understanding of concepts related to the developmental origins of health and disease J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-01-23 M. Tohi, S. Tu’akoi, M. H. Vickers
The developmental origins of health and disease (DOHaD) framework has highlighted the importance of the early life period on disease risk in later life with impacts that can span generations. A primary focus to date has been around maternal health and the ‘First Thousand Days’ as a key developmental window whereby an adverse environment can have lasting impacts on both mother and offspring. More recently
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The impact of maternal and paternal birth weights on infant birth weights: the Japan environment and children’s study J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-01-22 Hasumi Tomita, Noriyuki Iwama, Hirotaka Hamada, Rie Kudo, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, The Japan Environment and Children’s Study Group
This study aimed to evaluate the association between parental and infant birth weights in Japan. In total, 37,504 pregnant Japanese women and their partners were included in this birth cohort study. A multinomial logistic regression model was used to evaluate the associations of parental birth weights with small-for-gestational-age (SGA) or large-for-gestational-age (LGA) infants. Associations between
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Maternal pea fiber supplementation to a high calorie diet in obese pregnancies protects male offspring from metabolic dysfunction in adulthood J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-01-18 Gabriella A. Andreani, Saleh Mahmood, Mulchand S. Patel, Todd C. Rideout
We investigated the influence of maternal yellow-pea fiber supplementation in obese pregnancies on offspring metabolic health in adulthood. Sixty newly-weaned female Sprague-Dawley rats were randomized to either a low-calorie control diet (CON) or high calorie obesogenic diet (HC) for 6-weeks. Obese animals were then fed either the HC diet alone or the HC diet supplemented with yellow-pea fiber (HC
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Association of birthweight with diabetes, hypertension, and ischemic heart disease in young adulthood: a retrospective cohort study J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-01-15 Yulika Yoshida-Montezuma, Charles D.G. Keown-Stoneman, Catherine S. Birken, Jonathon L. Maguire, Hilary K. Brown, Laura N. Anderson
Birthweight has been associated with diabetes in a reverse J-shape (highest risk at low birthweight and moderately high risk at high birthweight) and inversely associated with hypertension in adulthood with inconsistent evidence for cardiovascular disease. There is a lack of population-based studies examining the incidence of cardiometabolic outcomes in young adults born with low and high birthweights
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Empirical evidence of predictive adaptive response in humans: systematic review and meta-analysis of migrant populations J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-01-10 Clara Bueno López, Guillermo Gómez Moreno, Alberto Palloni
Meta-analysis is used to test a variant of a Developmental Origins of Adult Health and Disease (DOHaD)’s conjecture known as predictive adaptive response (PAR). According to it, individuals who are exposed to mismatches between adverse or constrained in utero conditions, on the one hand, and postnatal obesogenic environments, on the other, are at higher risk of developing adult chronic conditions,
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Associations of offspring birthweight and placental weight with subsequent parental coronary heart disease: survival regression using the walker cohort J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-01-09 Carlos Sánchez-Soriano, Ewan R. Pearson, Rebecca M. Reynolds
Low birth weight (BW) is consistently correlated with increased parental risk of subsequent cardiovascular disease, but the links with offspring placental weight (PW) are mostly unexplored. We have investigated the associations between parental coronary heart disease (CHD) and offspring BW and PW using the Walker cohort, a collection of 48,000 birth records from Dundee, Scotland, from the 1950s and
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Involuntary tobacco smoke exposures from conception to 18 years increase midlife cardiometabolic disease risk: a 40-year longitudinal study J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2024-01-08 Zhongzheng Niu, Lina Mu, Stephen L. Buka, Eric B. Loucks, Meng Wang, Lili Tian, Xiaozhong Wen
Few population studies have sufficient follow-up period to examine early-life exposures with later life diseases. A critical question is whether involuntary exposure to tobacco smoke from conception to adulthood increases the risk of cardiometabolic diseases (CMD) in midlife. In the Collaborative Perinatal Project, serum-validated maternal smoking during pregnancy (MSP) was assessed in the 1960s. At
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Upregulation of miR-21-5p rescues the inhibition of cardiomyocyte proliferation induced by high glucose through negative regulation of Rhob J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-12-11 Fang Wu, Feng Wang, Qian Yang, Yawen Zhang, Ke Cai, Jialing Zhang, Min Xia, Youhua Wang, Xu Wang, Yonghao Gui, Qiang Li
Increasing evidence shows that maternal hyperglycemia inhibits cardiomyocyte (CM) proliferation and promotes cell apoptosis during fetal heart development, which leads to cardiac dysplasia. Accumulating evidence suggests that the overexpression of miR-21 in CMs has a protective role in cardiac function. Therefore, we investigated whether miR-21 can rescue CM injury caused by high glucose. First, we
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Associations between epigenome-wide DNA methylation and height-related traits among Sub-Saharan Africans: the RODAM study J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-12-04 Galatea Swart, Karlijn Meeks, Felix Chilunga, Andrea Venema, Charles Agyemang, Eva van der Linden, Peter Henneman
Human height and related traits are highly complex, and extensively research has shown that these traits are determined by both genetic and environmental factors. Such factors may partially affect these traits through epigenetic programing. Epigenetic programing is dynamic and plays an important role in controlling gene expression and cell differentiation during (early) development. DNA methylation
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Neonatal nicotine exposure affects adult rat hepatic pathways involved in endoplasmic reticulum stress and macroautophagy in a sex-dependent manner J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-12-01 Luana Lopes Souza, Camila Lüdke Rossetti, Thamara Cherem Peixoto, Alex Christian Manhães, Egberto Gaspar de Moura, Patrícia Cristina Lisboa
Nonalcoholic fatty liver disease (NAFLD) involves changes in hepatic pathways, as lipogenesis, oxidative stress, endoplasmic reticulum (ER) stress, and macroautophagy. Maternal nicotine exposure exclusively during lactation leads to fatty liver (steatosis) only in the adult male offspring, not in females. Therefore, our hypothesis is that neonatal exposure to nicotine sex-dependently affects the signaling
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Associations between early infections and childhood cognition in the Newcastle Thousand Families Study birth cohort J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-11-29 Erin Pennock, Emma L. Slack, Jess A. Grebby, Lara N. Forster, Mark S. Pearce
Childhood infections have been shown to stunt growth, contribute to malnutrition and reduce cognition in early adulthood. This study aimed to assess relationships between early life infections and childhood cognition at age 11 years in the Newcastle Thousand Families Study (NTFS). The analysis included 741 members from the NTFS who had complete data for infections between birth and 5 years, and the
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Stress response abnormalities transgenerationally inherited via miR-23 downregulation are restored by a methyl modulator during the lactation period J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-11-29 Takahiro Nemoto, Yuki Morita, Yoshihiko Kakinuma
Low birthweight rats due to fetal undernutrition sustain higher corticosterone levels when exposed to stress. This is due to the upregulated expression of the pituitary-specific Gas5, a long noncoding RNA (lncRNA) that acts as a glucocorticoid receptor decoy and then competitively inhibiting the binding of glucocorticoids to DNA. However, the mechanism of Gas5 lncRNA upregulation remains unclear. Therefore
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Developmental origins of health and disease knowledge is associated with diet quality in preconception young adult men and women J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-11-28 Lorentz Salvesen, Erlend Nuland Valen, Andrew Keith Wills, Elisabet Rudjord Hillesund, Frøydis Nordgård Vik, Dagrun Engeset, Nina Cecilie Øverby, Anine Christine Medin
The Developmental Origins of Health and Disease (DOHaD) approach supports that nutritional exposures in early life affect an individual’s later health and risk of disease. Dietary exposure during the preconception period may also influence individual, and inter- and transgenerational health and disease risk, in both men and women. This study aimed to describe knowledge of the DOHaD approach (DOHaDKNOWLEDGE)
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The impact of smoking and nicotine exposure during pregnancy on fetal nephrogenesis: a systematic review J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-11-16 Kelsey Popham, Yogavijayan Kandasamy
The effect of smoking and nicotine exposure during pregnancy on fetal nephrogenesis is a growing area of research. The objective of this systematic review is to summarise the current evidence in this research field. Our literature search identified a total of 415 articles from PubMed, Embase, Scopus, and Cochrane. After electronic sorting and manual screening, 18 eligible articles were found, 6 being
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Puberty as a DOHaD programming window: high-fat diet induces long-term hepatic dysfunction in male rats J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-11-13 Beatriz Gonçalves dos Santos, Rosiane Aparecida Miranda, Lucas Paulo Jacinto Saavedra, Flávio Andrade Francisco, Maiara Vanusa Guedes Ribeiro, Anna Rebeka Oliveira Ferreira, Marcos Divino Ferreira-Junior, Keilah Valéria Naves Cavalcante, Carlos Henrique Xavier, Egberto Gaspar de Moura, Patrícia Cristina Lisboa, Ariel Penha Carvalho da Mota, Gustavo Rodrigues Pedrino, James Andrew Armitage, Paulo Cezar
The aim of this study was to evaluate whether high-fat (HF) diet intake during puberty can program obesity as well as generate glucose imbalance and hepatic metabolic dysfunctions in adult life. Male Wistar rats were randomly assigned into two groups: rats fed standard chow (NF) and rats fed a HF from postnatal 30-day-old (PND30) until PND60. Then, both groups were fed a standard chow from PND60 until
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Preterm birth, birthweight, and subsequent risk for depression J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-10-27 Neha Rahalkar, Aaron Holman-Vittone, Christian Daniele, Rachel Wacks, Autumn Gagnon, Amy D’Agata, Nazmus Saquib, Peter F. Schnatz, Mary C. Sullivan, Robert Wallace, Cassandra N. Spracklen
An individual’s birthweight, a marker of in utero exposures, was recently associated with certain psychiatric conditions. However, studies investigating the relationship between an individual’s preterm birth status and/or birthweight and risk for depression during adulthood are sparse; we used data from the Women’s Health Initiative (WHI) to investigate these potential associations. At study entry
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Building strong health and career trajectories through translational research J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-10-13 M. Elizabeth O’Leary, Marina White, Julie Nihouarn Sigurdardottir, Hailey Scott, Angela Marcela Jaramillo-Ospina, Shameena Bake, Kristin L. Connor
Translational research (TR) is the movement of fundamental scientific discoveries into healthcare settings and population health policy, and parallels the goals of DOHaD research. Unfortunately, there is little guidance on how to become a translational researcher. To understand the opinions of DOHaD trainees towards TR, we conducted a workshop at the DOHaD World Congress 2022. We found that trainees
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Alteration of the embryonic microenvironment and sex-specific responses of the preimplantation embryo related to a maternal high-fat diet in the rabbit model J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-10-12 Sophie Calderari, Catherine Archilla, Luc Jouneau, Nathalie Daniel, Nathalie Peynot, Michele Dahirel, Christophe Richard, Eve Mourier, Barbara Schmaltz-Panneau, Anaïs Vitorino Carvalho, Delphine Rousseau-Ralliard, Franck Lager, Carmen Marchiol, Gilles Renault, Julie Gatien, Lydie Nadal-Desbarats, Anne Couturier-Tarrade, Véronique Duranthon, Pascale Chavatte-Palmer
The maternal metabolic environment can be detrimental to the health of the offspring. In a previous work, we showed that maternal high-fat (HH) feeding in rabbit induced sex-dependent metabolic adaptation in the fetus and led to metabolic syndrome in adult offspring. As early development representing a critical window of susceptibility, in the present work we aimed to explore the effects of the HH
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Maternal childhood maltreatment: associations to offspring brain volume and white matter connectivity J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-09-21 Claudia Lugo-Candelas, Le Chang, Jordan D. Dworkin, Natalie Aw, Andrea Fields, Hannah Reed, Marisa Spann, Michelle A. Gilchrist, Walter Hinds, Rachel Marsh, William P. Fifer, Myrna Weissman, Bernd Uwe Foerster, Marina Giorgi Manin, Ivaldo Silva, Bradley Peterson, Ana Carolina Coelho Milani, Jay Gingrich, Catherine Monk, Cristiane S. Duarte, Andrea Jackowski, Jonathan Posner
The deleterious effects of adversity are likely intergenerational, such that one generation’s adverse experiences can affect the next. Epidemiological studies link maternal adversity to offspring depression and anxiety, possibly via transmission mechanisms that influence offspring fronto-limbic connectivity. However, studies have not thoroughly disassociated postnatal exposure effects nor considered
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Factors associated with low birthweight among late preterm singletons in Japan using pregnancy birth registry data J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-09-13 Yoshifumi Kasuga, Kunio Tanaka, Keisuke Akita, Junko Tamai, Asuka Hamuro, Yuka Fukuma, Keita Hasegawa, Satoru Ikenoue, Mamoru Tanaka
Late preterm (LP, born between 34 0/7 and 36 6/7 weeks of gestation) infants may experience several adverse outcomes, similar to those experienced by low birthweight (LBW, birthweight <2500 g) infants. However, while LP infants are often born with LBW, the association between LP and LBW remains unknown. This study aimed to investigate LBW rate and independent risk factors for LBW in LP singleton neonates
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Association of maternal psychosocial stress with newborn body composition in the Healthy Start study J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-09-11 Kaitlin E. Buck, Satvinder K. Dhaliwal, Dana Dabelea, Wei Perng
Maternal psychosocial stress is associated with delivery of both small- and large-for-gestational-age newborns. Prior studies have relied on methods that do not capture fat mass (FM) vs. fat-free mass (FFM). We aimed to assess the relationship of maternal psychosocial stress, using the Edinburgh Postnatal Depression Scale (EPDS) and Cohen’s Perceived Stress Scale (PSS), with newborn body composition
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Preeclampsia and risk of maternal pulmonary hypertension at high altitude in Bolivia J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-07-27 C. E. Salinas, O. V. Patey, C. Murillo, M. Gonzales, V. Espinoza, S. Mendoza, R. Ruiz, R. Vargas, Y. Perez, J. Montaño, L. Toledo-Jaldin, A. Badner, J. Jimenez, J. Peñaranda, C. Romero, M. Aguilar, L. Riveros, I. Arana, D. A. Giussani
Women with a history of preeclampsia (PE) have a greater risk of pulmonary arterial hypertension (PAH). In turn, pregnancy at high altitude is a risk factor for PE. However, whether women who develop PE during highland pregnancy are at risk of PAH before and after birth has not been investigated. We tested the hypothesis that during highland pregnancy, women who develop PE are at greater risk of PAH
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Relationships between the maternal prenatal diet and epigenetic state in infants: a systematic review of human studies J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-07-27 Kathya K. Fernando, Jeffrey M. Craig, Samantha L. Dawson
Most human studies investigating the relationship between maternal diet in pregnancy and infant epigenetic state have focused on macro- and micro-nutrient intake, rather than the whole diet. This makes it difficult to translate the evidence into practical prenatal dietary recommendations. To review the evidence on how the prenatal diet relates to the epigenetic state of infants measured in the first
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The impact of adversities across the lifespan on psychological symptom profiles in late adulthood: a latent profile analysis J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-07-21 C. E. Hilberdink, M. van Zuiden, M. Olff, T. J. Roseboom, S. R. de Rooij
People commonly face adverse circumstances throughout life, which increases risk for psychiatric disorders, such as anxiety, depression, psychosis, and posttraumatic stress disorder (PTSD). Adversities may occur during different periods in life. Especially adversity during early periods has been suggested to put individuals at risk for adverse mental health outcomes. Here, we investigated whether timing
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Early neurodevelopment in the offspring of women enrolled in a randomized controlled trial assessing the effectiveness of a nutrition + exercise intervention on the cognitive development of 12-month-olds J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-07-14 Neda Mortaji, John Krzeczkowski, Stephanie Atkinson, Bahar Amani, Louis A. Schmidt, Ryan J. Van Lieshout
Experimental data on the effects of lifestyle interventions on fetal neurodevelopment in humans remain scarce. This study assessed the impact of a pregnancy nutrition+exercise intervention on offspring neurodevelopment at 12 months of age. The Be Healthy in Pregnancy (BHIP) randomized controlled trial (RCT) randomly assigned pregnant persons with stratification by site and body mass index (BMI) to
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Relationship between insulin and Netrin-1/DCC guidance cue pathway regulation in the prefrontal cortex of rodents exposed to prenatal dietary restriction J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-07-11 Aashita Batra, Santiago Cuesta, Marcio Bonesso Alves, Jose Maria Restrepo, Michel Giroux, Daniela Pereira Laureano, Amanda Brondani Mucellini Lovato, Patrícia Maidana Miguel, Tania Diniz Machado, Roberta Dalle Molle, Cecilia Flores, Patricia Pelufo Silveira
Fetal restriction (FR) alters insulin sensitivity, but it is unknown how the metabolic profile associated with restriction affects development of the dopamine (DA) system and DA-related behaviors. The Netrin-1/DCC guidance cue system participates in maturation of the mesocorticolimbic DA circuitry. Therefore, our objective was to identify if FR modifies Netrin-1/DCC receptor protein expression in the
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Obese mothers supplemented with melatonin during gestation and lactation ameliorate the male offspring’s pancreatic islet cellular composition and beta-cell function J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-06-27 Brenda A. Nagagata, Matheus Ajackson, Fernanda Ornellas, Carlos A. Mandarim-de-Lacerda, Marcia Barbosa Aguila
Melatonin supplementation to obese mothers during gestation and lactation might benefit the pancreatic islet cellular composition and beta-cell function in male offspring adulthood. C57BL/6 females (mothers) were assigned to two groups (n = 20/each) based on their consumption in control (C 17% kJ as fat) or high-fat diet (HF 49% kJ as fat). Mothers were supplemented with melatonin (Mel) (10 mg/kg daily)
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Preconception and prenatal maternal stress are associated with broad autism phenotype in young adults: Project Ice Storm J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-06-07 Xinyuan Li, David P. Laplante, Guillaume Elgbeili, Suzanne King
Studies show associations between prenatal maternal stress (PNMS) and child autism, with little attention paid to PNMS and autism in young adulthood. The broad autism phenotype (BAP), encompassing sub-clinical levels of autism, includes aloof personality, pragmatic language impairment and rigid personality. It remains unclear whether different aspects of PNMS explain variance in different BAP domains
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Potential long consequences from internal and external ecology: loss of gut microbiota antifragility in children from an industrialized population compared with an indigenous rural lifestyle J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-05-24 Isaac G-Santoyo, Elvia Ramírez-Carrillo, Jonathan Dominguez Sanchez, Oliver López-Corona
Human health is strongly mediated by the gut microbiota ecosystem, which, in turn, depends not only on its state but also on its dynamics and how it responds to perturbations. Healthy microbiota ecosystems tend to be in criticality and antifragile dynamics corresponding to a maximum complexity configuration, which may be assessed with information and network theory analysis. Under this complex system
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The co-occurrence and cumulative prevalence of hypertension, rheumatoid arthritis, and hypothyroidism in preterm-born women in the Women’s Health Initiative J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-05-18 Pamela L. Brewer, Amy L. D’Agata, Mary B. Roberts, Nazmus Saquib, Peter F. Schnatz, JoAnn Manson, Charles B. Eaton, Mary C. Sullivan
Emerging evidence suggests that preterm-born individuals (<37 weeks gestation) are at increased risk of developing chronic health conditions in adulthood. This study compared the prevalence, co-occurrence, and cumulative prevalence of three female predominant chronic health conditions – hypertension, rheumatoid arthritis [RA], and hypothyroidism – alone and concurrently. Of 82,514 U.S. women aged 50–79
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Protein restriction during peripubertal period impairs endothelial aortic function in adult male Wistar rats J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-05-18 Amanda Cristina de Souza, Deborah Gomes da Silva, Juliana da Silva Jezuíno, Anna Rebeka Oliveira Ferreira, Maiara Vanusa Guedes Ribeiro, Camila Borecki Vidigal, Kawane Fabricio Moura, Rafaela Pires Erthal, Paulo Cezar de Freitas Mathias, Glaura Scantamburlo Alves Fernandes, Kesia Palma-Rigo, Graziela Scalianti Ceravolo
Protein restriction during early phases of body development, such as intrauterine life can favor the development of vascular disorders. However, it is not known if peripubertal protein restriction can favor vascular dysfunction in adulthood. The present study aimed to evaluated whether a protein restriction diet during peripubertal period favors endothelial dysfunction in adulthood. Male Wistar rats
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Associations of maternal preterm birth with subsequent risk for type 2 diabetes in women from the women’s health initiative J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-04-28 Aaron Holman-Vittone, Brian Monahan, Erin S. LeBlanc, Simin Liu, Rami Nassir, Nazmus Saquib, Peter F. Schnatz, Aladdin H. Shadyab, Rachel Sinkey, Jean Wactawski-Wende, Robert A. Wild, Lisa Chasan-Taber, JoAnn E. Manson, Cassandra N. Spracklen
Preterm birth has been associated with insulin resistance and beta-cell dysfunction, a hallmark characteristic of type 2 diabetes. However, studies investigating the relationship between a personal history of being born preterm and type 2 diabetes are sparse. We sought to investigate the potential association between a personal history of being born preterm and risk for type 2 diabetes in a racially
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Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-04-28 Alicia White, Jane Stremming, Laura D. Brown, Paul J. Rozance
Insulin-like growth factor-1 (IGF-1) is a critical fetal growth hormone that has been proposed as a therapy for intrauterine growth restriction. We previously demonstrated that a 1-week IGF-1 LR3 infusion into fetal sheep reduces in vivo and in vitro insulin secretion suggesting an intrinsic islet defect. Our objective herein was to determine whether this intrinsic islet defect was related to chronicity
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Maternal protein restriction during the lactation period disrupts the ontogenetic development of behavioral traits in male Wistar rat offspring J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-04-26 Juliana de Oliveira-Silva, Patrícia C. Lisboa, Bruna Lotufo-Denucci, Mabel Fraga, Egberto G. de Moura, Fernanda C. Nunes, Anderson Ribeiro-Carvalho, Cláudio C. Filgueiras, Yael Abreu-Villaça, Alex C. Manhães
Neonatal undernutrition in rats results in short- and long-term behavioral and hormonal alterations in the offspring. It is not clear, however, whether these effects are present since the original insult or if they develop at some specific age later in life. Here, we assessed the ontogenetic profile of behavioral parameters associated with anxiety, exploration and memory/learning of Wistar rat offspring
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Lifetime caffeine and adolescent nicotine exposure in mice: effects on anxiety-like behavior and reward J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-04-03 Ana Carolina Dutra-Tavares, Anderson Ribeiro-Carvalho, Fernanda Nunes, Ulisses Cesar Araújo, Vitor Bruno, Tania Marcourakis, Claudio C. Filgueiras, Alex C. Manhães, Yael Abreu-Villaça
Caffeine consumption occurs throughout life, while nicotine use typically begins during adolescence, the period when caffeine-nicotine epidemiological association begins in earnest. Despite that, few studies in animal models parallel the pattern of coexposure that occurs in humans. Therefore, the neurobehavioral consequences of the association between these drugs remain unclear. Here, we exposed Swiss
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Associations between maternal folate status and choline intake during pregnancy and neurodevelopment at 3–4 years of age in the Alberta Pregnancy Outcomes and Nutrition (APrON) study J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-03-20 Nathalie Irvine, Gillian England-Mason, Catherine J. Field, Nicole Letourneau, Rhonda C. Bell, Gerald F. Giesbrecht, David W. Kinniburgh, Amy M. MacDonald, Jonathan W. Martin, Deborah Dewey, APrON Study Team
Folate and choline are methyl donor nutrients that may play a role in fetal brain development. Animal studies have reported that prenatal folate and choline supplementation are associated with better cognitive outcomes in offspring and that these nutrients may interact and affect brain development. Human studies that have investigated associations between maternal prenatal folate or choline levels
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Moderate maternal nutrient reduction in pregnancy alters fatty acid oxidation and RNA splicing in the nonhuman primate fetal liver J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-03-16 Kip D. Zimmerman, Jeannie Chan, Jeremy P. Glenn, Shifra Birnbaum, Cun Li, Peter W. Nathanielsz, Michael Olivier, Laura A. Cox
Fetal liver tissue collected from a nonhuman primate (NHP) baboon model of maternal nutrient reduction (MNR) at four gestational time points (90, 120, 140, and 165 days gestation [dG], term in the baboon is ∼185 dG) was used to quantify MNR effects on the fetal liver transcriptome. 28 transcripts demonstrated different expression patterns between MNR and control livers during the second half of gestation
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Oral pyrroloquinoline quinone (PQQ) during pregnancy increases cardiomyocyte endowment in spontaneous IUGR guinea pigs J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-03-02 Jordan Mattern, Andrew Gemmell, Paige E. Allen, Katherine E. Mathers, Timothy R.H. Regnault, Brian K. Stansfield
Background: Intrauterine growth restriction (IUGR) exerts a negative impact on developing cardiomyocytes and emerging evidence suggests activation of oxidative stress pathways plays a key role in this altered development. Here, we provided pregnant guinea pig sows with PQQ, an aromatic tricyclic o-quinone that functions as a redox cofactor antioxidant, during the last half of gestation as a potential
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Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-02-23 Rosiane Aparecida Miranda, Vanessa Silva Tavares Rodrigues, Thamara Cherem Peixoto, Alex C. Manhães, Egberto Gaspar de Moura, Patricia Cristina Lisboa
Early nicotine exposure compromises offspring’s phenotype at long-term in both sexes. We hypothesize that offspring exposed to nicotine during breastfeeding show deregulated central and peripheral endocannabinoid system (ECS), compromising several aspects of their metabolism. Lactating rats received nicotine (NIC, 6 mg/Kg/day) or saline from postnatal day (PND) 2 to 16 through implanted osmotic minipumps
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Placental nanoparticle gene therapy normalizes gene expression changes in the fetal liver associated with fetal growth restriction in a fetal sex-specific manner J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-02-16 Rebecca L. Wilson, Kendal K. Stephens, Helen N. Jones
Fetal growth restriction (FGR) is associated with increased risk of developing non-communicable diseases. We have a placenta-specific nanoparticle gene therapy protocol that increases placental expression of human insulin-like growth factor 1 (hIGF1), for the treatment of FGR in utero. We aimed to characterize the effects of FGR on hepatic gluconeogenesis pathways during early stages of FGR establishment
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Prenatal dietary patterns in relation to adolescent offspring adiposity and adipokines in a Mexico City cohort J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-01-19 Erica Fossee, Astrid N. Zamora, Karen E. Peterson, Alejandra Cantoral, Wei Perng, Martha M. Téllez-Rojo, Libni A. Torres-Olascoaga, Erica C. Jansen
Maternal diet during pregnancy has been associated with obesity among offspring. The extent to which trimester-specific dietary patterns are associated with markers of adiposity during adolescence remains unclear. We examined associations between prenatal diet patterns with adolescent offspring measures of adiposity and adipokines in 384 mother–adolescent dyads from the Mexico City ELEMENT cohort.
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Maternal prenatal psychological distress and motor/cognitive development in two-year-old offspring: The Japan Environment and Children’s Study J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-01-18 Miyuki Mori, Toshie Nishigori, Yuka Ogata, Taeko Suzuki, Akiko Sato, Tsuyoshi Murata, Hyo Kyozuka, Akiko Yamaguchi, Hirohito Metoki, Yoshie Shinohara, Toshifumi Takahashi, Kosei Shinoki, Mitsuaki Hosoya, Keiya Fujimori, Seiji Yasumura, Koichi Hashimoto, Aya Goto, Hidekazu Nishigori, The Japan Environment and Children’s Study Group
Maternal prenatal psychological distress, including depression and anxiety, may affect offspring’s motor/cognitive development. However, research findings have been inconsistent. We used a dataset from the Japan Environment and Children’s Study to evaluate associations between maternal six-item Kessler Psychological Distress Scale (K6) scores and motor/cognitive development among offspring at two years
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Cardiovascular and renal profiles in rat offspring that do not undergo catch-up growth after exposure to maternal protein restriction J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-01-17 Ryan J. Wood-Bradley, Sarah L. Henry, Roger G. Evans, John F. Bertram, Luise A. Cullen-McEwen, James A. Armitage
Maternal protein restriction is often associated with structural and functional sequelae in offspring, particularly affecting growth and renal-cardiovascular function. However, there is little understanding as to whether hypertension and kidney disease occur because of a primary nephron deficit or whether controlling postnatal growth can result in normal renal-cardiovascular phenotypes. To investigate
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Differential expression of genes influencing mitotic processes in cord blood mononuclear cells after a pre-conceptional micronutrient-based randomised controlled trial: Pune Rural Intervention in Young Adolescents (PRIYA) J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2023-01-12 Satyajeet P. Khare, Ayush Madhok, Indumathi Patta, Krishna K. Sukla, Vipul V. Wagh, Pooja S. Kunte, Deepa Raut, Dattatray Bhat, Kalyanaraman Kumaran, Caroline Fall, Utpal Tatu, Giriraj R. Chandak, Chittaranjan S. Yajnik, Sanjeev Galande
In The Pune Maternal Nutrition Study, vitamin B12 deficiency was seen in 65% of pregnant women, folate deficiency was rare. Maternal total homocysteine concentrations were inversely associated with offspring birthweight, and low vitamin B12 and high folate concentrations predicted higher offspring adiposity and insulin resistance. These findings guided a nested pre-conceptional randomised controlled
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Prenatal trimester-specific intake of micronutrients: global DNA methylation and hydroxymethylation at birth and persistence in childhood J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2022-12-14 Ella Parsons, Sheryl L. Rifas-Shiman, Anne K. Bozack, Andrea A. Baccarelli, Dawn L. DeMeo, Marie-France Hivert, Lode Godderis, Radu-Corneliu Duca, Emily Oken, Andres Cardenas
The prenatal environment may program health and disease susceptibility via epigenetic mechanisms. We evaluated associations of maternal trimester-specific intake of micronutrients with global DNA methylation (%5mC) and 5-hydroxymethylation (%5hmC) at birth in cord blood and tested for persistence into childhood. We quantified global %5mC and %5hmC in cord blood cells (n = 434) and in leukocytes collected
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Latent growth analysis of children’s height growth trajectories J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2022-11-30 Senahara Korsa Wake, Temesgen Zewotir, Essey Kebede Muluneh
Characterizing and quantifying the trajectories of variables of interest through time in their field of study is of interest to a range of disciplines. The aim of this study was to investigate the growth speed in height of children and its determinants. A total of 3401 males and 3200 females from four low- and middle-income countries with measured height on five occasions from 2002 to 2016 were included
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Myocardial perfusion and function dichotomy in growth restricted preterm infants J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2022-11-21 Arvind Sehgal, Beth J. Allison, Suzanne L. Miller, Graeme R. Polglase
Compared to preterm appropriate for gestational age (AGA) fetuses, fetuses with fetal growth restriction (FGR) have earlier visualisation of coronary artery blood flow (CABF) but impaired cardiac function. This dichotomy remains uncharacterised during postnatal life. This study compared CABF and cardiac function in preterm FGR infants, against AGA infants during the postnatal period. FGR was defined
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When a birth cohort grows up: challenges and opportunities in longitudinal developmental origins of health and disease (DOHaD) research J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2022-11-21 Emily Oken, Theresa M. Bastain, Nicole Bornkamp, Carrie V. Breton, Rebecca C. Fry, Diane R. Gold, Marie-France Hivert, Steve Howland, Daniel J. Jackson, Christine C. Johnson, Kyra Jones, MollyAn Killingbeck, T. Michael O’Shea, Marleny Ortega, Dennis Ownby, Frederica Perera, Julie V. Rollins, Julie B. Herbstman
High-quality evidence from prospective longitudinal studies in humans is essential to testing hypotheses related to the developmental origins of health and disease. In this paper, the authors draw upon their own experiences leading birth cohorts with longitudinal follow-up into adulthood to describe specific challenges and lessons learned. Challenges are substantial and grow over time. Long-term funding
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Understanding the importance of the early-life period for adult health: a systematic review J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2022-11-08 Jillian R. Hildreth, Mark H. Vickers, Tatjana Buklijas, Jacquie L. Bay
Evidence clearly indicates that the nutritional and non-nutritional environment and level of physical activity during the early-life period from preconception through infancy has a lifelong impact on the child’s health. However this message must be communicated effectively to parents and other stakeholders such as grandparents, health professionals, policymakers and the wider community in order for
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Malathion exposure during juvenile and peripubertal periods downregulate androgen receptor and 17-ß-HSD testicular gene expression and compromised sperm quality in rats J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2022-11-07 Rafaela Pires Erthal, Gláucia Eloisa Munhoz de Lion Siervo, Giovanna Fachetti Frigoli, Tiago Henrique Zaninelli, Waldiceu Aparecido Verri, Glaura Scantamburlo Alves Fernandes
Malathion is an insecticide that is used to control arboviruses and agricultural pests. Adolescents that are exposed to this insecticide are the most vulnerable as they are in the critical period of postnatal sexual development. This study aimed to evaluate whether malathion damage can affect sperm function and its respective mechanisms when adolescents are exposed during postnatal sexual development
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Treatment with topiramate in rats during childhood causes testicular structural impairment at adulthood J. Dev. Orig. Health Dis. (IF 1.7) Pub Date : 2022-11-03 Lorena Ireno Borges, Simone Forcato, Lays Cristine do Nascimento Olanda, Giovanna Fachetti Frigoli, Camila Borecki Vidigal, Kawane Fabrício Moura, Glaura Scantamburlo A. Fernandes, Maria do Carmo Pinho Franco, Graziela Scalianti Ceravolo, Daniela Cristina Ceccatto Gerardin
Topiramate (TOP) is a psychotropic drug prescribed for the treatment of epilepsy in children older than 2 years of age and for migraine prophylaxis in adolescents. There is evidence that TOP promotes negative effects on the reproductive system of male rats. This study aimed to evaluate the immediate and late treatment effects of TOP during childhood and adolescence on the male rat reproductive system