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Activation of ASIC3/ERK pathway by paeoniflorin improves intestinal fluid metabolism and visceral sensitivity in slow transit constipated rats Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-04-18 Yuan Deng, Qiong Zhao, Hong‐Yun Zhou, Zi‐Qi Zhang, Yu Zhan
Slow transit constipation (STC) is one of the most common gastrointestinal disorders in children and adults worldwide. Paeoniflorin (PF), a monoterpene glycoside compound extracted from the dried root of Paeonia lactiflora, has been found to alleviate STC, but the mechanisms of its effect remain unclear. The present study aimed to investigate the effects and mechanisms of PF on intestinal fluid metabolism
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Predictive effects of the interactions among cesarean section, birth weight, and preterm birth on the risk of atopic dermatitis in children Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-04-17 Chih‐Kai Wong, Cheng‐Fang Yen, Yi‐Lung Chen
Cesarean section (CS) and level of maturity at birth, as indicated by birth weight and gestational age, may influence the incidence of atopic dermatitis (AD); however, the findings of studies have been inconsistent. For example, research has revealed that CS increased the risk of AD by altering neonatal gut microflora colonization,1 whereas a meta-analysis did not observe a significant association
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Esophageal cancer localization by sagittal computed tomography images and endoscopic measurement Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-04-17 Jen Yang, Wei‐Lun Chang, Forn‐Chia Lin, Nan‐Tsing Chiu
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Enhanced expression of activity‐regulated cytoskeleton‐associated protein in the medial prefrontal cortex is involved in working memory performance Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-04-16 Tsan‐Ju Chen, Dean‐Chuan Wang, Pei‐Chun Liu, Hui‐Shan Hung, Tsung‐Lin Cheng
Working memory (WM) is a cognitive function important for guiding the on‐going or upcoming behavior. A memory‐related protein Arc (activity‐regulated cytoskeleton‐associated protein) is implicated in long‐term memory consolidation. Recent evidence further suggests the involvement of hippocampal Arc in spatial WM. The medial prefrontal cortex (mPFC) is a key brain region mediating WM. However, the role
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The efficacy of multi‐disciplinary lifestyle modifications in Taiwanese nonalcoholic steatohepatitis patients Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-04-16 Ming‐Lun Yeh, Chia‐Yen Dai, Chung‐Feng Huang, Shiu‐Feng Huang, Pei‐Chien Tsai, Po‐Yau Hsu, Ching‐I Huang, Yu‐Ju Wei, Po‐Cheng Liang, Ming‐Jong Bair, Mei‐Hsuan Lee, Zu‐Yau Lin, Jee‐Fu Huang, Ming‐Lung Yu, Wan‐Long Chuang
Lifestyle modification is the standard of care for nonalcoholic fatty liver disease (NAFLD) patients. We aimed to investigate the efficacy of a short‐term lifestyle modification program in the disease course of Taiwanese nonalcoholic steatohepatitis (NASH) patients with paired biopsies. All patients received a 6‐month, strict multidisciplinary program of lifestyle modifications led by physicians, dieticians
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Successful intraoperative radiation therapy for a rapidly recurrent smooth muscle tumor of uncertain malignant potential Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-04-16 Yu‐Hsuan Chung, Peir‐In Liang, Feng‐Hsiang Tang
Smooth muscle tumors of uncertain malignant potential (STUMPs) represent a group of rare uterine neoplasms whose morphological features are between those of leiomyoma and leiomyosarcoma.1 STUMP recurrence poses a major challenge because no gold standard for treatment has been established. The present case highlights the effective use of intraoperative radiotherapy (IORT) as a salvage technique in a
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Increased serum adipokines are associated with sarcopenia in non‐obese women with rheumatoid arthritis Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-04-11 Tzu‐Jung Fang, Min‐Hsi Chiu, Ming‐Shyan Huang, Chia‐Yen Dai, Yao‐Tsung Yeh, Jeng‐Hsien Yen
Large cohort studies have disclosed the association between obesity and rheumatoid arthritis (RA) risk. The sarcopenia prevalence in RA patients can be up to 31%. However, there is little information linking adipokines to sarcopenia in RA, so this study aimed to investigate whether adipokines were indeed involved in secondary sarcopenia in RA with a focus on non‐obese females. Sixty‐four female patients
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NTRK3 exhibits a pro‐oncogenic function in upper tract urothelial carcinomas Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-04-09 Lee‐Moay Lim, Yi‐Chen Lee, Ting‐Wei Lin, Zi‐Xuan Hong, Wei‐Chi Hsu, Hung‐Lung Ke, Daw‐Yang Hwang, Wen‐Yu Chung, Wei‐Ming Li, Hui‐Hui Lin, Hung‐Tien Kuo, A‐Mei Huang
Neurotrophic receptor tyrosine kinase 3 (NTRK3) has pleiotropic functions: it acts not only as an oncogene in breast and gastric cancers but also as a dependence receptor in tumor suppressor genes in colon cancer and neuroblastomas. However, the role of NTRK3 in upper tract urothelial carcinoma (UTUC) is not well documented. This study investigated the association between NTRK3 expression and outcomes
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Ultrasonographic and pathological findings of pseudomyogenic hemangioendothelioma Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-04-09 Gui‐Wu Chen, Xiao‐Ling Leng, Shao‐Ming Liu, Xiao‐Min Liao
Pseudomyogenic hemangioendothelioma (PHE) is an indolent and low-grade tumor that often mimics other benign and malignant lesions, making accurate diagnosis crucial for effective patient management.1 The variable clinical presentations and pathological features of PHE pose diagnostic challenges for inexperienced radiologists.2 Here, we present a 17-year-old man with PHE, characterized by ultrasonography
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Combination of chemotherapy and immunotherapy may overcome the resistance to immunotherapy alone in pulmonary lymphoepithelial carcinoma Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-04-09 Huei‐Yang Hung, Wei‐An Lai, Cheng‐Hao Chuang, Chih‐Jen Yang
Pulmonary lymphoepithelial carcinoma (PLEC) is a rare and challenging subtype of non-small cell lung cancer (NSCLC), accounting for only 0.25%–0.9% of all NSCLC cases.1 Due to its rarity, there are currently no established standardized treatment protocols for PLEC, leading physicians to often rely on multimodal treatment strategies, especially in advanced-stage cases.1, 2 This treatment typically includes
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Retraction: ‘ASPM predicts poor prognosis and regulates cell proliferation in bladder cancer’. Zhen‐Ya Gao, Fang Yu, Huan‐Xia Jia, Zhuo Ye, Shi‐Jie Yao, Kaohsiung J Med Sci. 2020; 36: 1021–1029 (https://doi.org/10.1002/kjm2.12284) Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-03-28
The above article, published online on 06 August 2020, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor‐in‐Chief, Wan‐Long Chuang, and John Wiley and Sons Australia, Ltd.The retraction has been agreed due to a high degree of similarity and duplication of figures previously published in five identified articles. The authors are
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CircITGA7 regulates malignant phenotypes in bladder cancer cells via targeting miR-330-3p/KLF10 axis Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-03-25 Xian-Xu Yang, Chao Wang
Bladder cancer (BCa) is one of the common malignancies. Circular RNAs (circRNAs) play regulatory roles in cancer progression. CircITGA7 is a circRNA generated from several exons of ITGA7. The potential role of circITGA7 in BCa remains unknown and needs to be explored. Quantitative real time polymerase chain reaction (qRT-PCR) was used to assess circITGA7 and miR-330-3p expression in BCa tissues and
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Clinical outcome of bevacizumab or ramucirumab combined with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors as the first line therapy in susceptible EGFR‐mutated advanced non‐small‐cell lung Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-03-25 Chia‐Yu Kuo, Ming‐Ju Tsai, Jen‐Yu Hung, Mei‐Hsuan Lee, Kuan‐Li Wu, Yu‐Chen Tsai, Cheng‐Hao Chuang, Chung‐Wen Huang, Chin‐Ling Chen, Chih‐Jen Yang, Inn‐Wen Chong
Combining epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an anti‐ vascular endothelial growth factor (VEGF) agent, bevacizumab or ramucirumab, is indicated for advanced lung adenocarcinoma harboring EGFR mutation. This study aimed to show the real‐world data of combination therapy and compare the effectiveness between bevacizumab and ramucirumab in combination with an
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Factors related to parenting difficulties and depression in the COVID‐19 pandemic Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-03-19 Ching‐Shu Tsai, Ray C. Hsiao, Cheng‐Fang Yen
Parents have encountered multidimensional stressors when caring for their children during the coronavirus disease 2019 (COVID-19) pandemic.1 Such parenting challenges have been reported to be associated with parental distress and mental health problems.2 These findings underscore the necessity of further investigating parenting difficulties among parents of children during the COVID-19 pandemic. Identifying
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Surgical excision and radiotherapy for brain metastasis from colorectal cancer: How frailty and comorbidity indices influence outcome Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-03-14 Chia-En Wong, Yu Chang, Chi-Chen Huang, Hao-Hsiang Hsu, Yu-Hsuan Lai, Kwang-Yu Chang, Chih-Yuan Huang, Liang-Chao Wang, Jung-Shun Lee, Po-Hsuan Lee
The incidence of brain metastasis (BM) from colorectal cancer (CRC) is increasing. This study aims to identify the clinical prognosticators and evaluate the prognostic validity of common comorbidity indices in patients with BM from CRC. This retrospective single-center study analyzed 93 patients with BM from CRC who received surgical excision and/or radiotherapy. The clinical characteristics and prognostic
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Folic acid‐decorated astrocytes‐derived exosomes enhanced the effect of temozolomide against glioma Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-03-14 Hong‐Ming Liu, Ye Zhang
A direct strategy to achieve specific treatments and reduce side effects is through cell type‐specific drug delivery. Exosomes (Exos) can be modified with folic acid (FA) to prepare drug delivery systems targeting tumor cells that highly express FA receptors. This study aimed to produce an exo drug delivery system with FA decoration and temozolomide (TMZ) loading to improve the sustained TMZ release
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Duration of the preemptive analgesic effects of low‐ and high‐frequency transcutaneous electrical nerve stimulation in rats with acute inflammatory pain Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-03-06 Hideshi Ikemoto, Naoki Adachi, Takayuki Okumo, Oyunchimeg Chuluunbat, Tadashi Hisamitsu, Masataka Sunagawa
Transcutaneous electrical nerve stimulation (TENS) activates various pathways to induce antinociceptive effects, based on the frequencies used. This study evaluates the preemptive analgesic effects and their duration of low‐ (LT: 4 Hz) and high‐frequency TENS (HT: 100 Hz) using a rat model of acute inflammatory pain. Acute inflammation was induced by injecting 1% formalin into the hind paws of rats
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A potential novel technique for measurement of pulp volume on periapical radiography: A pilot study Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-03-06 Samed Şatır, Şelale Özel, Kaan Orhan
Pulp volume can be assessed during dental treatment. Three‐dimensional imaging techniques are not routinely used for this purpose because of high radiation doses. This study aimed to develop a novel method to measure pulp volume using periapical radiography. In this study, cone‐beam computed tomography (CBCT) was used as a reference method. Periapical radiography and CBCTs obtained from the same patients
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An unusual case of mesenteric fibromatosis Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-03-01 Yu‐Cheng Chiang, Po‐Hsuan Wu
A 35-year-old male presented at our emergency department with a 2-week history of abdominal fullness, pain, and vomiting. He had no underlying health conditions, previous surgeries, or familial cancer history. Physical examination and lab tests in the emergency room were unremarkable, revealing no palpable abdominal mass. However, an abdominal computed tomography (CT) scan showed a 7.5 × 5.2 cm mesenteric
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GLI family zinc finger protein 2 promotes skin fibroblast proliferation and DNA damage repair by targeting the miR‐200/ataxia telangiectasia mutated axis in diabetic wound healing Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-02-22 Zun‐Hong Liang, Shi‐Shuai Lin, Zhi‐Yang Qiu, Yun‐Chuan Pan, Nan‐Fang Pan, Yun Liu
Diabetic foot ulcer (DFU) is a serious complication of diabetic patients which negatively affects their foot health. This study aimed to estimate the role and mechanism of the miR‐200 family in DNA damage of diabetic wound healing. Human foreskin fibroblasts (HFF‐1 cells) were stimulated with high glucose (HG). Db/db mice were utilized to conduct the DFU in vivo model. Cell viability was evaluated
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Seronegative Immunoglobulin G4-related hypertrophic pachymeningitis misdiagnosed as meningitis and meningioma Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-02-16 Meng-Leo Chou, Hui-Chun Chen, Shih-Huang Tai, Chin-Wei Huang
Immunoglobulin G (IgG)-4-related hypertrophic pachymeningitis represents a rare manifestation of IgG4-related disease (IgG4-RD), characterized by a multi-organ fibroinflammatory disorder featuring tumefactive lesions with distinctive pathological features. Typically, this condition manifests through localized or diffuse thickening of the dura mater, and in some instances, tumor-like lesions have been
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Precursor B-cell lymphoblastic lymphoma presenting as concurrent enlarging masses on the scalp and postauricular region in a 13-year-old boy Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-02-16 Wei-Yao Wang, Sheau-Fang Yang, Yu-Wen Cheng, Yang-Yi Chen
A 13-year-old Taiwanese boy presented with a 6-month history of enlarging, asymptomatic scalp and postauricular masses. No fever, weight loss, or night sweats were present. Physical examination showed a dome-shaped, firm, non-tender, erythematous mass measuring 5 cm in diameter on the right parietal scalp (Figure 1A,B), and enlarged lymph nodes measuring 1.5 cm in the right postauricular region (Figure 1C)
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Third vaccine boosters and anti-S-IgG levels: A comparison of homologous and heterologous responses and poor immunogenicity in hepatocellular carcinoma Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-02-16 Chih-Wen Wang, Chung-Feng Huang, Tyng-Yuan Jang, Ming-Lun Yeh, Po-Cheng Liang, Yu-Ju Wei, Po-Yao Hsu, Ching-I. Huang, Ming-Yen Hsieh, Yi-Hung Lin, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Ming-Lung Yu
The immune response of patients with chronic liver disease tends to be lower after receiving their second coronavirus disease 2019 (COVID-19) vaccine dose, but the effect of a third vaccine dose on their immune response is currently unknown. We recruited 722 patients without previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from three hospitals. The patients received homologous
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Hyperthyroidism after radiofrequency ablation for thyroid nodule Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-02-19 How-Chen Wang, Che-Wei Wu, Tzu-Yen Huang
Radiofrequency ablation (RFA) is a novel treatment for selected thyroid nodules and is known for its low complication rate when performed precisely.1, 2 Hyperthyroidism typically occurs within 2–4 weeks post-RFA, is transient and self-limiting and is hypothesized to be caused by destructive thyroiditis.1 We present a case of hyperthyroidism that developed 3 months post-RFA. A 41-year-old Taiwanese
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LncRNA HOTTIP regulates TLR4 promoter methylation by recruiting H3K4 methyltransferase MLL1 to affect apoptosis and inflammatory response of fibroblast-like synoviocyte in rheumatoid arthritis Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-02-16 Guan Wang, Yu-Lin Xu, Xi-Hai Zhang, Lian Tang, Yao Li
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease, and the role of HOXA transcript at the distal tip (HOTTIP) in its pathogenesis remains underexplored. This study investigates the mechanism by which HOTTIP influences apoptosis and the inflammatory response of fibroblast-like synoviocytes (FLS). An RA mouse model was established, and clinical scores were analyzed. Pathological
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A case of upper gastrointestinal bleeding due to pancreatic pseudoaneurysm rupture Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-02-16 Hui-Qi Siew, Ming-Lun Yeh
Pseudoaneurysm was an uncommon complication of acute pancreatitis, which was occurred when an erosion of a peripancreatic or pancreatic artery into a pseudocyst.1 Pancreatic pseudoaneurysm might rupture or form a fistula into the adjacent hollow organs, causing a life-threatening bleeding. Herein, we reported a case of severe upper gastrointestinal (GI) bleeding due to pancreatic pseudoaneurysm ruptured
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Validating the accuracy of the Hendrich II Fall Risk Model for hospitalized patients using the ROC curve analysis Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-02-16 Chieh-Ying Hu, Li-Chen Sun, Ming-Yen Lin, Mei-Hsing Chen, Hsin-Tien Hsu
This retrospective study was conducted at a medical center in southern Taiwan to assess the accuracy of the Hendrich II Fall Risk Model (HIIFRM) in predicting falls. Sensitivity, specificity, accuracy, and optimal cutoff points were analyzed using receiver operating characteristic (ROC) curves. Data analysis was conducted using information from the electronic medical record and patient safety reporting
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Magnolin alleviated DSS-induced colitis by inhibiting ALOX5-mediated ferroptosis Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-02-10 Ting Yao, Yuan-Yuan Yao, Jin-Zhi Wang, Shi-Man Jiang, Lan-Juan Li
Inflammatory bowel disease (IBD) is a chronic and incurable disorder associated with higher cancer risk and currently faces unsatisfactory treatment outcomes. Ferroptotic cells secrete damage-associated molecular patterns (DAMPs) that recruit and activate immune cells, particularly macrophages. Magnolin has excellent antioxidant and anti-inflammatory properties, but its effect on IBD has not yet been
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Female showed favorable left ventricle hypertrophy regression during post-TAVR follow-up Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-02-08 Cheng-An Chiu, Pin-Rong Chen, Yu-Ju Li, Chong-Chao Hsieh, Hui-Chen Yu, Chaw-Chi Chiu, Jiann-Woei Huang, Chun-Yuan Chu, Tsung-Hsien Lin, Hsiang-Chun Lee
Transcatheter aortic valve replacement (TAVR) is a well-established procedure using a catheter-introduced valve prosthesis for patients with severe aortic stenosis (AS). This retrospective study investigated sex-related differences in pre- and post-TAVR clinical and hemodynamic outcomes and analyzed data of the first 100 cases at Kaohsiung Medical University Chung-Ho Memorial Hospital (KMUH) between
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Gypenoside XIII regulates lipid metabolism in HepG2 hepatocytes and ameliorates nonalcoholic steatohepatitis in mice Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-01-31 Shu-Chen Cheng, Chian-Jiun Liou, Ya-Xuan Wu, Kuo-Wei Yeh, Li-Chen Chen, Wen-Chung Huang
Gypenoside XIII is isolated from Gynostemma pentaphyllum (Thunb.) Makino. In mice, G. pentaphyllum extract and gypenoside LXXV have been shown to improve non-alcoholic steatohepatitis (NASH). This study investigated whether gypenoside XIII can regulate lipid accumulation in fatty liver cells or attenuate NASH in mice. We used HepG2 hepatocytes to establish a fatty liver cell model using 0.5 mM oleic
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miR-107-5p ameliorates neurological damage, oxidative stress, and immune responses in mice with Alzheimer's disease by suppressing the Toll-like receptor 4 (TLR4)/nuclear factor-kappaB(NF-κB) pathway Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-01-19 Guang-Jun Hu, Xiao-Yang Jiang, Si-Yu Du, Kun Zhang, Zhuo Chen
Alzheimer's disease (AD) is a progressively debilitating neurodegenerative condition primarily affecting the elderly. Emerging research suggests that microRNAs (miRNAs) play a role in the development of AD. This study investigates the impact of miR-107-5p on neurological damage, oxidative stress, and immune responses in AD. We utilized APP/PS1 mice as AD mouse models and C57BL/6 J mice as controls
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Evodiamine inhibits EPRS expression to regulate glutamate metabolism and proliferation of oral squamous cell carcinoma cells Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-01-19 Li-Qi Lin, Si-Yi Lv, Hao-Zhe Ren, Rong-Rong Li, Lin Li, Yun-Qing Pang, Jing Wang
The effects of evodiamine (EVO) on oral squamous cell carcinoma (OSCC) are not yet understood. Based on our earlier findings, we hypothesized that evodiamine may affect OSCC cell proliferation and glutamate metabolism by modulating the expression of EPRS (glutamyl-prolyl-tRNA synthetase 1). From GEPIA, we obtained EPRS expression data in patients with OSCC as well as survival prognosis data. An animal
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Performance of noninvasive seromarkers in predicting liver fibrosis among MAFLD patients with or without viral hepatitis Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-01-17 Chung-Feng Huang, Po-Cheng Liang, Chih-Wen Wang, Tyng-Yuan Jang, Po-Yao Hsu, Pei-Chien Tsai, Yu-Ju Wei, Ming-Lun Yeh, Ming-Yen Hsieh, Yi-Hung Lin, Chao-Kuan Huang, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Ming-Lung Yu
The accuracy of noninvasive seromarkers in predicting liver fibrosis in metabolic dysfunction-associated fatty liver disease (MAFLD) patients with or without viral hepatitis is elusive. The AST to platelet ratio index (APRI), fibrosis-4 index (FIB-4), and NAFLD fibrosis score (NFS) were assessed in 871 MAFLD patients who received elastography in a viral hepatitis-endemic area. The area under the receiver
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MiR-214-3p overexpression-triggered chondroitin polymerizing factor (CHPF) inhibition modulates the ferroptosis and metabolism in colon cancer Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-01-08 Zhi-Yuan Yun, Di Wu, Xin Wang, Peng Huang, Na Li
Colon cancer is a common cancer with high mortality globally. The role of chondroitin polymerizing factor (CHPF) has been elucidated in various cancers. However, its role and mechanism remain unknown in colon cancer. CHPF expression was examined by GEPIA database, reverse transcription-quantitative polymerase chain reaction and western blot. The relationship between CHPF expression and the clinicopathologic
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Recent advances in the treatment of type 2 diabetes mellitus using new drug therapies Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-01-06 Keong Chong, Jack Keng-Jui Chang, Lee-Ming Chuang
Several recent advances provide multiple health benefits to individuals with type 2 diabetes mellitus (T2DM). Pharmacological therapy is governed by person-centered factors, including comorbidities and treatment goals. Adults with T2DM who have an established/high risk of atherosclerotic cardiovascular disease, heart failure, and/or chronic kidney disease, require a treatment regimen that includes
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TGFB1I1 promotes cell proliferation and migration in urothelial carcinoma Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-01-05 Peir-In Liang, Yu-Ching Wei, Huan-Da Chen, Yu-Chun Ma, Hung-Lung Ke, Chu-Chun Chien, Hao-Wen Chuang
Urothelial carcinoma (UC) is common cancer worldwide with a high prevalence in Taiwan, especially in the upper urinary tract, including the renal pelvis and ureter, also classifying as upper urinary tract urothelial carcinoma. Here, we aim to find a representative prognostic marker that strongly correlates to this type of carcinoma. Transforming growth factor beta-1-induced transcript 1 (TGFB1I1) is
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CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-01-05 Zhang-Zhang Lan, Feng-Hua Sun, Chuan Chen, Li Niu, Jing-Dong Shi, Wen-Yong Zhang
Circular RNA (circRNA) plays a key part in the pathological process of gastric cancer (GC). The study is organized to analyze the function of circPRDM5 in GC cell tumor properties. Expression levels of circPRDM5, miR-485-3p, glucosaminyl (N-acetyl) transferase 4 (GCNT4), ki67, E-cadherin, N-cadherin, and hexokinase 2 (HK2) were analyzed by quantitative real-time polymerase chain reaction (PCR), Western
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CircFN1 promotes acute myeloid leukemia cell proliferation and invasion but refrains apoptosis via miR-1294/ARHGEF10L axis Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2024-01-05 Sheng Wang, Bang-Shuo Zhang, Yi Yang, Lin-Lin Fu
Previous studies have proved circFN1 is highly expressed in acute myeloid leukemia (AML) patients and AML cell lines. This study aims to investigate the impact of circFN1 on AML and its mechanism. Via real-time quantitative PCR to detect circFN1, miR-1294, ARHGEF10L expressions in clinical plasma samples and AML cell lines, AML cells were cultured in vitro and transfected with si-circFN1, pcDNA3.1-circFN1
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Predictive value of hyperhidrosis for the incidence of type 2 diabetes mellitus: A population-based cohort study in Taiwan Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-12-26 Chih-Kai Wong, Ray C. Hsiao, Mu-Hong Chen, Cheng-Fang Yen
Hyperhidrosis is thought to stem from the impaired negative feedback mechanism to the hypothalamus, causing the overactivation of the sympathetic nervous system (SNS) and neurogenic hyperexcitability of the reflex circuits; then sweat glands of the body are hyperstimulated and sweat more than what is needed to cool the body.1 Review studies have demonstrated that SNS overactivation increases the risk
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Retraction: Protective effect of hsa-miR-570-3p targeting CD274 on triple negative breast cancer by blocking PI3K/AKT/mTOR signaling pathway. Li-Li Wang, Wei-Wei Huang, Jing Huang, Rong-Fang Huang, Na-Ni Li, Yi Hong, Mu-Lan Chen, Fan Wu, Jian Liu, Kaohsiung J Med Sci. 2020; 36(8): 581–591 (https://doi.org/10.1002/kjm2.12212) Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-12-13
The above article, published online on 20 April 2020, and a corresponding corrigendum for Figure 7, published on 14 March 2022, in Wiley Online Library (wileyonlinelibrary.com), have been retracted by agreement between the authors, the journal Editor-in-Chief, Wan-Long Chuang, and John Wiley and Sons Ltd.
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Effect of wearing a surgical mask on intraocular pressure during COVID-19 pandemic Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-12-13 Shao-Yu Sung, Kwou-Yeung Wu, Hung-Chi Lai, Han-Yi Tseng
During the COVID-19 pandemic, individuals were asked to wear a face mask in public in specific situations. Face masks are important components of personal protective equipment for transmitted diseases. On the other hand, Intraocular pressure (IOP) is necessary for clinical evaluation and is the only adjustable factor for the progression of glaucomatous optic neuropathy. IOP could be affected by variable
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Camrelizumab in combination with neoadjuvant chemotherapy in resectable locally advanced esophageal squamous carcinoma cancer: Results from a retrospective study Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-12-13 Ning-Ning Kang, Hao Zheng, Jin-Xiu Hu, Kai Cui, Pan-Pan Si, Wei Ge
This study aimed to evaluate the safety and efficacy of camrelizumab combined with chemotherapy during preoperative neoadjuvant therapy in patients with locally advanced resectable esophageal squamous cell carcinoma (ESCC) of clinical Stages II and III. The patients received camrelizumab plus chemotherapy regimen on Day 1 for up to three to four cycles (3 weeks per cycle). The probabilities of overall
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METTL3-mediated m6A methylation of TRAF5 inhibits lung adenocarcinoma cell metastasis via activation of the PI3K/AKT/NF-κB signaling pathway Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-12-13 Yu-Fei Zhou, Jiang-Tao Li, Qing-Lin Zheng, Kun-Lun Ren, Cheng-Cheng Yi
Tumor necrosis factor receptor-associated factor 5 (TRAF5) has been implicated in the pathogenesis of human malignancies. This work aimed to clarify the role of TRAF5 in lung adenocarcinoma (LUAD) progression. Herein, we uncovered that TRAF5 level was reduced in LUAD tissues. Low TRAF5 expression correlated with dismal prognosis in LUAD patients. Moreover, upregulated TRAF5 impeded cell viability,
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Melanoma-associated retinopathy with presentation of transient multiple hyper-autofluorescent dots Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-12-07 Chih-Ying Lin, Yi-Ching Shao, Wen-Lu Chen, San-Ni Chen
Melanoma-associated retinopathy (MAR) is a rare paraneoplastic syndrome occurring in patients with cutaneous melanoma. Moreover, MAR may herald a possibility of metastasis.1 MAR is difficult to diagnose due to non-specific findings of fundus exam. Diagnosis depends on history of melanoma, symptoms of night blindness, visual field (VF) loss and electronegative b-wave on Electroretinogram (ERG).2 Due
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Role and mechanism of esketamine in improving postoperative cognitive dysfunction in aged mice through the TLR4/MyD88/p38 MAPK pathway Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-29 Hu-Jun Xu, Xian-Peng Li, Li-Ye Han
Postoperative cognitive dysfunction (POCD) is a significant concern for the elderly population worldwide. This study explored the effects of esketamine on aged mice with POCD and investigate its mechanism of action involving the TLR4/MyD88/MAPK pathway. We administrated esketamine, along with lipopolysaccharide or anisomycin, to the aged POCD mouse models. We assessed their cognitive function using
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Dynamic change in silent sinus syndrome Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-29 Shih-Wei Wang, Ling-Feng Wang, Tzu-Yen Huang, Chih-Feng Tai
A 32-year-old male patient presented to the otolaryngology outpatient department after experiencing visible progressive facial misalignment for 3 weeks. He complained about the sunken appearance of his left eye and the asymmetric protrusion of his bilateral maxillary bone. However, he had no history of recent facial trauma, sinus surgery, or any nasal or ophthalmological symptoms. Physical examination
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Curcumin suppresses the Wnt/β-catenin signaling pathway by inhibiting NKD2 methylation to ameliorate intestinal ischemia/reperfusion injury Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-27 Jia-Xi Zhu, Yu Dun, Wei Wu, Jie Shen, Feng Zhang, Lin Zhang
Intestinal ischemia/reperfusion (I/R) injury is a life-threatening condition with no effective treatment currently available. Curcumin (CCM), a polyphenol compound in Curcuma Longa, reportedly has positive effects against intestinal I/R injury. However, the mechanism underlying the protective effect of CCM against intestinal I/R injury has not been fully clarified. To determine whether the protective
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Hepatitis C virus micro-elimination in people who inject drugs: Challenges and chance in Taiwan and worldwide Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-27 Chi-Ming Tai, Ming-Lung Yu
With the introduction of direct-acting antivirals, elimination of hepatitis C virus (HCV) infection is becoming possible. People who inject drugs (PWID) represent a population with a high risk for HCV infection, which has been reported as high as 90% in Taiwanese PWID. To reach the goal of HCV elimination, PWID is a key population deserving special attention. Barriers in HCV care cascade still exist
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Tissue and serum miR-149-3p/5p in hospitalized patients with inflammatory bowel disease: Correlation with disease severity and inflammatory markers Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-23 Shuang Luo, Xi-Han Chen
This study aimed to investigate the expression levels of tissue and serum miR-149-3p and miR-149-5p in hospitalized patients with inflammatory bowel disease (IBD). A total of 35 ulcerative colitis (UC) patients, 12 Crohn's disease (CD) patients, and 25 healthy controls were included in the study. The miRNAs expressions were measured in tissue and serum samples using quantitative real-time polymerase
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Molecular mechanism of WWP1-mediated ubiquitination modification affecting proliferation and invasion/migration of liver cancer cells Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-23 Chao Zhang, Wei Wang, Biao Wu
Liver cancer is the most prevalent fatal malignancy across the globe. The present study aims to explore the molecular mechanism of E3 ligase WWP1 in liver cancer cell proliferation and invasion/migration. RT-qPCR and Western blot were performed to detect WWP1, KLF14, and VEPH1 expressions in liver cancer cell lines. Furthermore, WWP1 expression was silenced in cells, followed by the detection of cell
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Salvianolic acid A improves nerve regeneration and repairs nerve defects in rats with brain injury by downregulating miR-212-3p-mediated SOX7 Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-21 Shuai Huang, Hong-Liang Wang
This study was to probe the protective effects and mechanisms of salvianolic acid A (SAA) on cerebral ischemia–reperfusion injury (CIRI). The middle cerebral artery occlusion model (MCAO) was established in rats. Rats' behavior, neurological deficits, brain injury, inflammation, and apoptosis in the brain tissue were evaluated. The inflammatory response and apoptosis of PC12 cells induced by oxygen
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Reviewer Acknowledgment Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-20
Consistent high-quality of papers published in “Kaohsiung Journal of Medical Sciences” can only be maintained with the cooperation and dedication of a number of expert referees. The Editors would like to thank all those who have donated the hours necessary to review, evaluate and comment on manuscripts; their conscientious efforts have enabled the journal to maintain its tradition of excellence. We
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LncRNA MYLK antisense RNA 1 activates cell division cycle 42/Neutal Wiskott-Aldrich syndrome protein pathway via microRNA-101-5p to accelerate epithelial-to-mesenchymal transition of colon cancer cells Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-11 Zhen-Hao Quan, Fei-Peng Xu, Zhe Huang, Ri-Hong Chen, Qing-Wen Xu, Lin Lin
Long noncoding RNA MYLK antisense RNA 1 (MYLK-AS1) is the crux in multiple diseases. Therefore, the purpose of this study was to investigate the possible mechanism of MYLK-AS1. A total of 62 colon cancer (CC) specimens and paired adjacent normal tissues were collected, and the expression of MYLK-AS1, microRNA (miR)-101-5p/cell division cycle 42 (CDC42) was detected. CC cell lines were transfected with
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Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-10 Tyng-Yuan Jang, Chi-Chang Ho, Po-Cheng Liang, Chih-Da Wu, Yu-Ju Wei, Pei-Chien Tsai, Po-Yao Hsu, Ming-Yen Hsieh, Yi-Hung Lin, Meng-Hsuan Hsieh, Chih-Wen Wang, Jeng-Fu Yang, Ming-Lun Yeh, Chung-Feng Huang, Wan-Long Chuang, Jee-Fu Huang, Ya-Yun Cheng, Chia-Yen Dai, Pau-Chung Chen, Ming-Lung Yu
We aimed to investigate the association between air pollution and advanced fibrosis among patients with metabolic associated fatty liver disease (MAFLD) and chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. A total of 1376 participants who were seropositive for HBV surface antigen (HBsAg) or antibodies to HCV (anti-HCV) or had abnormal liver function in a community screening program
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Patient-centered and integrated outreach care for chronic hepatitis C patients with serious mental illness in Taiwan Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-09 Chung-Feng Huang, Tyng-Yuan Jang, Shun-Chieh Yu, Shin-Chung Huang, Shao-Lun Ho, Ming-Lun Yeh, Chih-Wen Wang, Po-Cheng Liang, Yu-Ju Wei, Po-Yao Hsu, Ching-I Huang, Ming-Yen Hsieh, Yi-Hung Lin, Sung-Lin Yu, Pey-Fang Wu, Yu-Han Chen, Shin-Chi Chien, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Tso-Jen Wang, Ming-Lung Yu
Patients with serious mental illness have a higher risk of hepatitis C virus (HCV) infection but suboptimal HCV care. The current study aimed to facilitate HCV treatment uptake by implementing an integrated outreach care model. Multidisciplinary outreach screening followed by HCV reflex testing and onsite treatment for schizophrenia patients was accomplished through the coordination of nongovernmental
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Impact of interleukin-1β single nucleotide polymorphisms and depressive symptoms in individuals with chronic viral hepatitis Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-08 Hsin-Yi Huang, Rwei-Ling Yu, Wei-Fang Tsai, Wan-Long Chuang, Jee-Fu Huang, Chia-Yen Dai, Chun-Hsiang Tan
Elevated levels of interleukin 1β (IL-1β) have been identified in patients with chronic viral hepatitis and have been associated with depressive symptoms. Given the high prevalence of depression in this patient population, this study sought to explore the potential influence of IL-1β genetic variations on the severity of depressive symptoms. In a cohort of 181 Taiwanese patients with chronic viral
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Reduced miR-513a-5p expression in COPD may regulate airway mucous cell hyperplasia through TFR1-dependent signaling Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-02 Jia Zhou, Jun-Yi Du, Rui Xu, Xiao-Juan Wu, Guo-Yue Zhang
Airway mucous cell metaplasia and mucous hypersecretion is one of the key characteristic pathophysiological status of chronic obstructive pulmonary disease (COPD). micro(mi)RNAs are acknowledged as non-encoding RNA molecules playing important roles in gene expression regulation. In this study, we searched the Gene Expression Omnibus (GEO) database for the differentially expressed miRNAs between COPD
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EGFR-mediated hyperacetylation of tubulin induced docetaxel resistance by downregulation of HDAC6 and upregulation of MCAK and PLK1 in prostate cancer cells Kaohsiung J. Med. Sci. (IF 3.3) Pub Date : 2023-11-02 Yeong-Shiau Pu, Chao-Yuan Huang, Hung-Lin Wu, Jyun-Hong Wu, Ying-Fang Su, Chang-Tze Ricky Yu, Chi-Yu Lu, Wen-Jeng Wu, Shu-Pin Huang, Ying-Tang Huang, Tzyh-Chyuan Hour
Docetaxel-based chemotherapy has generally been considered as one of the effective treatments for castration-resistant prostate cancer (PCa). However, clinical treatment with docetaxel often encounters a number of undesirable effects, including drug resistance. Tubulin isoforms have been previously examined for their resistance to docetaxel in many cancers, but their real mechanisms remained unclear