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Understanding host–pathogen interaction: paving the path for individualized anti-infective therapy Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2024-04-10 Isabelle Bekeredjian-Ding
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Topical application of ozonated sunflower oil accelerates the healing of lesions of cutaneous leishmaniasis in mice under meglumine antimoniate treatment Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2024-03-27 Ana Paula Pivotto, Lucas Bonatto de Souza Lima, Alexandra Michelon, Camilla Zottesso Pellon Ferreira, Rinaldo Ferreira Gandra, Thaís Soprani Ayala, Rafael Andrade Menolli
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The Moraxella catarrhalis AdhC–FghA system is important for formaldehyde detoxification and protection against pulmonary clearance Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2024-03-06 Dina Othman, Noha M. Elhosseiny, Wafaa N. Eltayeb, Ahmed S. Attia
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Inflammation, the kynurenines, and mucosal injury during human experimental enterotoxigenic Escherichia coli infection Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2024-03-02 Sehee Rim, Oda Barth Vedøy, Ingeborg Brønstad, Adrian McCann, Klaus Meyer, Hans Steinsland, Kurt Hanevik
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Advances in the understanding of circRNAs that influence viral replication in host cells Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2024-02-08 Siya Wang, Xiaoyun Li, Geng Liu, Zhenyu Qiu, Jiamin Wang, Di Yang, Zilin Qiao, Zhongren Ma, Zhenbin Liu, Xiaoming Yang
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Echinacoside, a promising sortase A inhibitor, combined with vancomycin against murine models of MRSA-induced pneumonia Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-10-05 Tao Jiang, Dai Yuan, Rong Wang, Chunhui Zhao, Yangming Xu, Yinghui Liu, Wu Song, Xin Su, Bingmei Wang
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Comparative genotyping of SARS-CoV-2 among Egyptian patients: near-full length genomic sequences versus selected spike and nucleocapsid regions Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-10-04 Rasha Emad, Iman S. Naga
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Expression of mammalian cell entry genes in clinical isolates of M. tuberculosis and the cell entry potential and immunological reactivity of the Rv0590A protein Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-10-03 Chanchal Kumar, Kamal Shrivastava, Anupriya Singh, Varsha Chauhan, Astha Giri, Shraddha Gupta, Naresh Kumar Sharma, Mridula Bose, Sadhna Sharma, Mandira Varma-Basil
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Prediction of outcome using CD14++CD16−, CD14++CD16+ and CD14+CD16++ monocyte subpopulations in patients with complicated intra-abdominal infections Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-09-08 Evgeni Dimitrov, Krasimira Halacheva, Georgi Minkov, Emil Enchev, Yovcho Yovtchev
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Eicosapentaenoic acid influences the pathogenesis of Candida albicans in Caenorhabditis elegans via inhibition of hyphal formation and stimulation of the host immune response Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-09-06 N. Z. Mokoena, H. Steyn, A. Hugo, T. Dix-Peek, C. Dickens, O. M. N. Gcilitshana, O. Sebolai, J. Albertyn, C. H. Pohl
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Histone methyltransferase SETD2 inhibits M1 macrophage polarization and glycolysis by suppressing HIF-1α in sepsis-induced acute lung injury Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-09-01 Yan Meng, Kai-wen Kong, Yong-qing Chang, Xiao-ming Deng, Tao Yang
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CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-08-31 Zhengxia Wang, Wei Liu, Huidi Hu, Jingxian Jiang, Chen Yang, Xijie Zhang, Qi Yuan, Xiaofan Yang, Mao Huang, Yanming Bao, Ningfei Ji, Mingshun Zhang
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Ten rapid antigen tests for SARS-CoV-2 widely differ in their ability to detect Omicron-BA.4 and -BA.5 Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-08-10 Franziska Krenn, Christopher Dächert, Irina Badell, Gaia Lupoli, Gamze Naz Öztan, Tianle Feng, Nikolas Schneider, Melanie Huber, Hanna Both, Patricia M. Späth, Maximilian Muenchhoff, Alexander Graf, Stefan Krebs, Helmut Blum, Jürgen Durner, Ludwig Czibere, Lars Kaderali, Oliver T. Keppler, Hanna-Mari Baldauf, Andreas Osterman
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Automated antigen assays display a high heterogeneity for the detection of SARS-CoV-2 variants of concern, including several Omicron sublineages Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-08-10 Andreas Osterman, Franziska Krenn, Maximilian Iglhaut, Irina Badell, Andreas Lehner, Patricia M. Späth, Marcel Stern, Hanna Both, Sabine Bender, Maximilian Muenchhoff, Alexander Graf, Stefan Krebs, Helmut Blum, Timo Grimmer, Jürgen Durner, Ludwig Czibere, Christopher Dächert, Natascha Grzimek-Koschewa, Ulrike Protzer, Lars Kaderali, Hanna-Mari Baldauf, Oliver T. Keppler
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COVID-19 recurrence is related to disease-early profile T cells while detection of anti-S1 IgG is related to multifunctional T cells Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-07-25 Camilla Natália O. Santos, Gustavo C. Caldas, Fabricia A. de Oliveira, Angela Maria da Silva, João S. da Silva, Ricardo Luís L. da Silva, Amélia R. de Jesus, Lucas S. Magalhães, Roque P. de Almeida
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Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-07-21 Ebene R. Haycroft, Samantha K. Davis, Pradhipa Ramanathan, Ester Lopez, Ruth A. Purcell, Li Lynn Tan, Phillip Pymm, Bruce D. Wines, P. Mark Hogarth, Adam K. Wheatley, Jennifer A. Juno, Samuel J. Redmond, Nicholas A. Gherardin, Dale I. Godfrey, Wai-Hong Tham, Kevin John Selva, Stephen J. Kent, Amy W. Chung
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Correction to: Picking up speed: cell cycle regulation during effector CD8+ T cell differentiation Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-06-21 Lorenz Kretschmer, Noémie Fuchs, Dirk H. Busch, Veit R. Buchholz
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Association of IFIH1 and DDX58 genes polymorphism with susceptibility to COVID-19 Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-06-13 Parisa Feizollahi, Mohammad Hossein Zamanian, Sara Falahi, Farhad Salari, Zahra Mahmoudi, Elham Faryadi, Ali Gorgin Karaji, Alireza Rezaiemanesh
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Innate immune response in patients with acute Chikungunya disease Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-06-07 Wallace Pitanga Bezerra, Raíza Nara Cunha Moizéis, Amanda Costa Ayres Salmeron, Hannaly Wana Bezerra Pereira, Josélio Maria Galvão de Araújo, Paulo Marcos Matta Guedes, José Veríssimo Fernandes, Manuela Sales Lima Nascimento
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Pentraxin 3, a serum biomarker in human T-cell lymphotropic virus type-1-associated myelopathy patients and asymptomatic carriers Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-06-06 Motahareh Manzarinejad, Zohreh Vahidi, Reza Boostani, Majid Khadem-Rezaiyan, Houshang Rafatpanah, Fariba Zemorshidi
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Picking up speed: cell cycle regulation during effector CD8+ T cell differentiation Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-06-06 Lorenz Kretschmer, Noémie Fuchs, Dirk H. Busch, Veit R. Buchholz
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Gene biomarkers and classifiers for various subtypes of HTLV-1-caused ATLL cancer identified by a combination of differential gene co‑expression and support vector machine algorithms Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-05-24 Mohadeseh Zarei Ghobadi, Elaheh Afsaneh, Rahman Emamzadeh
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Trimer stability of Helicobacter pylori HtrA is regulated by a natural mutation in the protease domain Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-05-14 Urszula Zarzecka, Nicole Tegtmeyer, Heinrich Sticht, Steffen Backert
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Phenotypic and genotypic identification of carbapenem resistance in Bacteroides fragilis clinical strains Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-05-13 Marta Kierzkowska, Anna Majewska, Konrad Karłowicz, Hanna Pituch
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The quantity and quality of anti-SARS-CoV-2 antibodies show contrariwise association with COVID-19 severity: lessons learned from IgG avidity Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-04-27 Mehrdad Hajilooi, Fariba Keramat, Akram Moazenian, Mohsen Rastegari-Pouyani, Ghasem Solgi
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Detection of DENV-2 and ZIKV coinfection in southeastern Brazil by serum and urine testing Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-04-07 Pâmela Jóyce Previdelli da Conceição, Lucas Rodrigues de Carvalho, Bianca Lara Venâncio de Godoy, Mauricio Lacerda Nogueira, Ana Carolina Bernardes Terzian, Moacir Fernandes de Godoy, Marília Freitas Calmon, Cintia Bittar, Paula Rahal
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Editorial on special issue on "Immunobiology of Viral Infections". Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-04-01 Hanna-Mari Baldauf,Asisa Volz
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IgG antibody response to pneumococcal-conjugated vaccine (Prevenar®13) in children with immunodeficiency disorders Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2023-01-03 Marta Garrido-Jareño, José Miguel Sahuquillo-Arce, Héctor Rodríguez-Vega, Carmen Lloret-Sos, Ana Gil-Brusola, José Luis López-Hontangas, María Nuñez-Beltran, Jordi Tortosa-Carreres, José Ángel García-García, Lourdes Cordón, Leonor Puchades-Carrasco, Carmen Carreras-Gil de Santivañes, Antonio Pineda-Lucena, Javier Pemán-García
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Intrinsic D614G and P681R/H mutations in SARS-CoV-2 VoCs Alpha, Delta, Omicron and viruses with D614G plus key signature mutations in spike protein alters fusogenicity and infectivity Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-12-30 Ritika Khatri, Gazala Siddqui, Srikanth Sadhu, Vikas Maithil, Preeti Vishwakarma, Bharat Lohiya, Abhishek Goswami, Shubbir Ahmed, Amit Awasthi, Sweety Samal
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A high CMV-specific T cell response associates with SARS-CoV-2-specific IL-17 T cell production Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-12-13 Fernanda Tereza Bovi Frozza, Tiago Fazolo, Priscila Oliveira de Souza, Karina Lima, Julia Crispim da Fontoura, Théo Souza Borba, Márcia Polese-Bonatto, Luciane Beatriz Kern, Renato T. Stein, Graham Pawelec, Cristina Bonorino
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Acinetobacter baumannii reinforces the pathogenesis by promoting IL-17 production in a mouse pneumonia model Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-12-03 Yangyang Zhou, Chuanying Xiang, Ning Wang, Xiaomin Zhang, Yu Xie, Hong Yang, Gang Guo, Kaiyun Liu, Yan Li, Yun Shi
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SARS-CoV-2 infection in the context of Kawasaki disease and multisystem inflammatory syndrome in children Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-11-17 Barbara Anna Folga, Corrinna Jade Karpenko, Bogna Grygiel-Górniak
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In vitro and in vivo therapeutic antileishmanial potential of ellagic acid against Leishmania donovani in murine model Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-11-18 Poonam Keshav, Deepak Kumar Goyal, Sukhbir Kaur
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Reduced neutralization against Delta, Gamma, Mu, and Omicron BA.1 variants of SARS-CoV-2 from previous non-Omicron infection Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-11-12 Paola Pidal, Jorge Fernández, Constanza Airola, Miguel Araujo, Ana María Menjiba, Héctor San Martín, Nicole Bruneau, Monserrat Balanda, Coral Elgueta, Rodrigo Fasce, María Teresa Valenzuela, Ariel Orellana, Eugenio Ramírez
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Variable detection of Omicron-BA.1 and -BA.2 by SARS-CoV-2 rapid antigen tests Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-11-12 Andreas Osterman, Irina Badell, Christopher Dächert, Nikolas Schneider, Anna-Yasemin Kaufmann, Gamze Naz Öztan, Melanie Huber, Patricia M. Späth, Marcel Stern, Hanna Autenrieth, Maximilian Muenchhoff, Alexander Graf, Stefan Krebs, Helmut Blum, Ludwig Czibere, Jürgen Durner, Lars Kaderali, Hanna‑Mari Baldauf, Oliver T. Keppler
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A comparative study of IL-33 and its receptor ST2 in a C57BL/6 J mouse model of pulmonary Cryptococcus neoformans infection Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-11-11 Zhengxia Wang, Qiyun Ma, Jingxian Jiang, Xiaofan Yang, Enrui Zhang, Yuan Tao, Huidi Hu, Mao Huang, Ningfei Ji, Mingshun Zhang
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Obituary Prof. Ulrich Vogel, MD 1964–2022: a scientific mentor and expert in infection prevention and control Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-11-03 Oliver Kurzai, Heike Claus, Thien-Trí Lâm
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Resistance to fosfomycin is increasing and is significantly associated with extended-spectrum β-lactamase-production in urinary isolates of Escherichia coli Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-09-03 Esther Ríos, María del Carmen López Diaz, Esther Culebras, Iciar Rodríguez-Avial, Carmen Rodríguez-Avial
Fosfomycin has become a therapeutic option in urinary tract infections. Our objective was to evaluate the in vitro activity of fosfomycin against Escherichia coli isolated from urine samples in 2013, 2018 and 2021. We also determined a putative association between fosfomycin resistance and extended-spectrum β-lactamases (ESBL) production. Fosfomycin activity was evaluated against 7367, 8128 and 5072
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Low rate of asymptomatic carriage and salivary immunoglobulin A response to Group A Streptococci in the healthy adult population in Finland Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-09-02 Emilia Lönnqvist, Kirsi Gröndahl-Yli-Hannuksela, Vuokko Loimaranta, Jaana Vuopio
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Human cytomegalovirus (HCMV) long-term shedding and HCMV-specific immune response in pregnant women with primary HCMV infection Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-08-12 C. Fornara, F. Zavaglio, M. Furione, A. Sarasini, P. d’Angelo, A. Arossa, A. Spinillo, D. Lilleri, F. Baldanti
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Changes in circulating TCF1- and GARP-associated regulatory T cell subsets reflect the clinical status of patients with chronic HBV infection Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-08-11 Ayibaota Bahabayi, Xingyue Zeng, Bulidierxin Tuerhanbayi, Yangyang Zhang, Ainizati Hasimu, Siyu Guo, Tianci Liu, Mohan Zheng, Xiayidan Alimu, Chen Liu
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Immune complexes as culprits of immunopathology in severe COVID-19 Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-07-23 Philipp Kolb, Sebastian Giese, Reinhard Edmund Voll, Hartmut Hengel, Valeria Falcone
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Immunological imbalance in microcephalic children with congenital Zika virus syndrome Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-07-20 Amanda Costa Ayres Salmeron, Wallace Pitanga Bezerra, Rafaela Lúcia Lopes de Souza, Luanderson Cardoso Pereira, Lícia Maria do Nascimento, Anna Cláudia Calvielli Castelo Branco, Luiza Emilia Cavalcanti Simas, Valéria Azevedo de Almeida, Pedro Henrique de Souza Palmeira, Christiane Medeiros Bezerra, Paulo Marcos Matta Guedes, Maria Notomi Sato, Valéria Soraya de Farias Sales, Reginaldo Antônio de Oliveira
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Schistosoma mansoni infection decreases IL-33-mRNA expression and increases CXCL9 and CXCL10 production by peripheral blood cells Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-07-11 Wheverton Ricardo Correia do Nascimento, Cassia Giselle de Oliveira Nóbrega, Erica de Souza Fernandes, Patrícia d’Emery Alves Santos, Fábio Lopes Melo, Mônica Camelo Pessôa de Azevedo Albuquerque, Virgínia Maria Barros de Lorena, Vláudia Maria Assis Costa, Constança Clara Gayoso Simões Barbosa, Valdênia Maria Oliveira de Souza
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Mitochondria: intracellular sentinels of infections Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-07-05 Dominik Brokatzky, Georg Häcker
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SARS-CoV-2 herd immunity of the Kyrgyz population in 2021 Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-07-02 Anna Y. Popova, Omor T. Kasymov, Vyacheslav Y. Smolenski, Vyacheslav S. Smirnov, Svetlana A. Egorova, Zuridin S. Nurmatov, Anzhelika M. Milichkina, Gulmira S. Suranbaeva, Tatiana E. Kuchuk, Irina V. Khamitova, Elena V. Zueva, Valery A. Ivanov, Zhanylai N. Nuridinova, Aisuluu A. Derkenbaeva, Victoria G. Drobyshevskaya, Gulsun Z. Sattarova, Marat T. Kaliev, Alexandra V. Gubanova, Oyuna B. Zhimbaeva,
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Child type 1 diabetes associated with mother vaginal bacteriome and mycobiome Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-06-14 A. L. Ruotsalainen, M. V. Tejesvi, P. Vänni, M. Suokas, P. Tossavainen, A. M. Pirttilä, A. Talvensaari-Mattila, R. Nissi
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Blood and saliva SARS-CoV-2 antibody levels in self-collected dried spot samples Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-06-13 Laura Lahdentausta, Anne Kivimäki, Lotta Oksanen, Marika Tallgren, Sampo Oksanen, Enni Sanmark, Aino Salminen, Ahmed Geneid, Mikko Sairanen, Susanna Paju, Kalle Saksela, Pirkko Pussinen, Milla Pietiäinen
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Mouse models in COVID-19 research: analyzing the adaptive immune response Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-06-04 Sabrina Clever, Asisa Volz
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Genetic variability in minor capsid protein (L2 gene) of human papillomavirus type 16 among Indian women Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-05-13 Arati Mane, Sanket Limaye, Linata Patil, Urmila Kulkarni-Kale
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Inflammatory cytokine profile and T cell responses in African tick bite fever patients Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-05-11 Jessica Rauch, Johannes Jochum, Philip Eisermann, Jana Gisbrecht, Katrin Völker, Friederike Hunstig, Ute Mehlhoop, Birgit Muntau, Dennis Tappe
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Cytokine responses of immunosuppressed and immunocompetent patients with Neoehrlichia mikurensis infection Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-04-17 Linda Wass, Hanne Quarsten, Per-Eric Lindgren, Pia Forsberg, Elisabet Skoog, Kenneth Nilsson, Christine Lingblom, Christine Wennerås
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Functional cross-species conservation of guanylate-binding proteins in innate immunity Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-04-13 Luca Schelle, João Vasco Côrte-Real, Pedro José Esteves, Joana Abrantes, Hanna-Mari Baldauf
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Interferon antagonists encoded by SARS-CoV-2 at a glance Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-04-02 Jung-Hyun Lee, Lennart Koepke, Frank Kirchhoff, Konstantin M. J. Sparrer
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Cytomegalovirus immune evasion sets the functional avidity threshold for protection by CD8 T cells Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-04-01 Sara Hamdan, Matthias J. Reddehase, Rafaela Holtappels
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HIV-1 restriction by SERINC5 Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-03-25 Lucía Cano-Ortiz, Tom Luedde, Carsten Münk
Serine incorporator 5 (SERINC5 or SER5) is a multipass transmembrane protein with ill-defined cellular activities. SER5 was recently described as a human immunodeficiency virus 1 (HIV-1) restriction factor capable of inhibiting HIV-1 that does not express its accessory protein Nef (Δ Nef). SER5 incorporated into the viral membrane impairs the entry of HIV-1 by disrupting the fusion between the viral
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Streptococcus pneumoniae exerts oxidative stress, subverts antioxidant signaling and autophagy in human corneal epithelial cells that is alleviated by tert-Butylhydroquinone Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-03-24 Prerana Sharma, Sanhita Roy
Streptococcus pneumoniae is one of the leading causes of bacterial keratitis in the developing world and globally. In the current study, we have determined oxidative stress as pathogenesis of S. pneumoniae infection in corneal tissues and human corneal epithelial cells (HCEC) and explored host immune response of HCEC towards S. pneumoniae. We also determined whether treatment with tert-Butylhydroquinone
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Molecular variants of SARS-CoV-2: antigenic properties and current vaccine efficacy Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-03-02 Amirmasoud Rayati Damavandi, Razieh Dowran, Sarah Al Sharif, Fatah Kashanchi, Reza Jafari
An ongoing pandemic of newly emerged SARS-CoV-2 has puzzled many scientists and health care policymakers around the globe. The appearance of the virus was accompanied by several distinct antigenic changes, specifically spike protein which is a key element for host cell entry of virus and major target of currently developing vaccines. Some of these mutations enable the virus to attach to receptors more
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Impaired detection of omicron by SARS-CoV-2 rapid antigen tests Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-02-20 Andreas Osterman, Irina Badell, Elif Basara, Marcel Stern, Fabian Kriesel, Marwa Eletreby, Gamze Naz Öztan, Melanie Huber, Hanna Autenrieth, Ricarda Knabe, Patricia M. Späth, Maximilian Muenchhoff, Alexander Graf, Stefan Krebs, Helmut Blum, Jürgen Durner, Ludwig Czibere, Christopher Dächert, Lars Kaderali, Hanna-Mari Baldauf, Oliver T. Keppler
Since autumn 2020, rapid antigen tests (RATs) have been implemented in several countries as an important pillar of the national testing strategy to rapidly screen for infections on site during the SARS-CoV-2 pandemic. The current surge in infection rates around the globe is driven by the variant of concern (VoC) omicron (B.1.1.529). Here, we evaluated the performance of nine SARS-CoV-2 RATs in a single-centre
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Rapid and sensitive identification of omicron by variant-specific PCR and nanopore sequencing: paradigm for diagnostics of emerging SARS-CoV-2 variants Med. Microbiol. Immunol. (IF 5.4) Pub Date : 2022-01-21 Christopher Dächert, Maximilian Muenchhoff, Alexander Graf, Hanna Autenrieth, Sabine Bender, Helga Mairhofer, Paul R. Wratil, Susanne Thieme, Stefan Krebs, Natascha Grzimek-Koschewa, Helmut Blum, Oliver T. Keppler
On November 26, 2021, the World Health Organization classified B.1.1.529 as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VoC), named omicron. Spike-gene dropouts in conventional SARS-CoV-2 PCR systems have been reported over the last weeks as indirect diagnostic evidence for the identification of omicron. Here, we report the combination of PCRs specific for heavily