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Dysphagia as a Missing Link Between Post-surgical- and Opioid-Related Pneumonia Lung (IF 5.0) Pub Date : 2024-03-27 Michael Frazure, Clinton L. Greene, Kimberly E. Iceman, Dena R. Howland, Teresa Pitts
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First Exploration of the Altered Microbial Gut–Lung Axis in the Pathogenesis of Human Refractory Chronic Cough Lung (IF 5.0) Pub Date : 2024-03-25 Simone Baldi, Alessio Fabbrizzi, Leandro Di Gloria, Marco Pallecchi, Giulia Nannini, Mario D’Ambrosio, Cristina Luceri, Gianluca Bartolucci, Matteo Ramazzotti, Giovanni Fontana, Claudia Mannini, Federico Lavorini, Amedeo Amedei
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Relationship Between Diaphragm Thickness, Thickening Fraction, Dome Excursion, and Respiratory Pressures in Healthy Subjects: An Ultrasound Study Lung (IF 5.0) Pub Date : 2024-03-23
Abstract Purpose Diaphragm ultrasonography is used to identify causes of diaphragm dysfunction. However, its correlation with pulmonary function tests, including maximal inspiratory (MIP) and expiratory pressures (MEP), remains unclear. This study investigated this relationship by measuring diaphragm thickness, thickening fraction (TF), and excursion (DE) using ultrasonography, and their relationship
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Outcomes of Extracorporeal Life Support (ECLS) in Acute Severe Asthma: A Narrative Review Lung (IF 5.0) Pub Date : 2024-03-21 Nneoma Ekechukwu, Sachin Batra, Deborah Orsi, Marjan Rahmanian, Maneesha Bangar, Amira Mohamed
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Activated Leukocyte Cell Adhesion Molecule Regulates the Expression of Interleukin-33 in RSV Induced Airway Inflammation by Regulating MAPK Signaling Pathways Lung (IF 5.0) Pub Date : 2024-03-19 Seung Min Baek, Mi Na Kim, Eun Gyul Kim, Yu Jin Lee, Chang Hyun Park, Min Jung Kim, Kyung Won Kim, Myung Hyun Sohn
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Asymptomatic Dysphagia and Aspiration in Patients with Idiopathic Bronchiectasis Lung (IF 5.0) Pub Date : 2024-03-18 Tal Perluk, Eiman Abu Bandora, Ophir Freund, Tommy Jacob, Inbal Friedman Regev, Eyal Kleinhendler, Michal Shteinberg, Amir Bar-Shai, Yael Oestriecher-Kedem
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Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation Lung (IF 5.0) Pub Date : 2024-03-17 Kokilavani Sivaraman, Bin Liu, Beatriz Martinez-Delgado, Julia Held, Manuela Büttner, Thomas Illig, Sonja Volland, Gema Gomez-Mariano, Nils Jedicke, Tetyana Yevsa, Tobias Welte, David S. DeLuca, Sabine Wrenger, Beata Olejnicka, Sabina Janciauskiene
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Circulating Osteopontin Predicts Clinical and Radiological Response in First-Line Treatment of Advanced Non-Small Cell Lung Cancer Lung (IF 5.0) Pub Date : 2024-03-13 Davide Ramoni, Simona Coco, Giovanni Rossi, Chiara Dellepiane, Elisa Bennicelli, Sara Santamaria, Linda Zinoli, Alberto Stefano Tagliafico, Marco Tagliamento, Giulia Barletta, Luca Liberale, Amedeo Tirandi, Silvia Minetti, Maria Bertolotto, Fabrizio Montecucco, Carlo Genova, Federico Carbone
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Pressure Support Ventilation Versus T-piece as Spontaneous Breathing Trials for Extubation of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials Lung (IF 5.0) Pub Date : 2024-03-12
Abstract Background Weaning patients with COPD from mechanical ventilation (MV) presents a challenge, as literature on this topic is limited. This study compares PSV and T-piece during spontaneous breathing trials (SBT) in this specific population. Methods A search of PubMed, EMBASE, and Cochrane in September 2023 yielded four randomized controlled trials (RCTs) encompassing 560 patients. Among these
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Genetic Testing Goes Beyond Imaging and Histological Evaluation in Pleuroparenchymal Fibroelastosis Lung (IF 5.0) Pub Date : 2024-03-10
Abstract Background Lung biopsy remains the gold standard in the diagnosis of fibrotic interstitial lung disease (F-ILD), but there is a growing appreciation of the role of pathogenic gene variants in telomere and surfactant protein genes, especially in familial pulmonary fibrosis (FPF). Pleuroparenchymal fibroelastosis (PPFE) is a rare disease that can coexist with different patterns of F-ILD, including
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Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study Lung (IF 5.0) Pub Date : 2024-02-27 Ji-Yoon Oh, Sung-Yoon Kang, Noeul Kang, Ha-Kyeong Won, Eun-Jung Jo, Seung-Eun Lee, Ji-Hyang Lee, Ji-Su Shim, Young-Chan Kim, Youngsang Yoo, Jin An, Hwa Young Lee, So-Young Park, Mi-Yeong Kim, Ji-Ho Lee, Byung-Keun Kim, Han-Ki Park, Min-Hye Kim, Sae-Hoon Kim, Sang-Heon Kim, Yoon-Seok Chang, Sang-Hoon Kim, Byung-Jae Lee, Kian Fan Chung, Sang-Heon Cho, Woo-Jung Song
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Identification of Idiopathic Pulmonary Fibrosis and Prediction of Disease Severity via Machine Learning Analysis of Comprehensive Metabolic Panel and Complete Blood Count Data Lung (IF 5.0) Pub Date : 2024-02-20 Alex N. Mueller, Hunter A. Miller, Matthew J. Taylor, Sally A. Suliman, Hermann B. Frieboes
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Missing Nuts and Bolts: Translating Pulmonary Fibrosis from Preclinical Murine Models to Human Clinical Trials Lung (IF 5.0) Pub Date : 2024-02-07 Isaac Kirubakaran Sundar, Scott M. Matson
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Cardiovascular Events with the Use of Long-Acting Muscarinic Receptor Antagonists: An Analysis of the FAERS Database 2020–2023 Lung (IF 5.0) Pub Date : 2024-02-06 Maria Gabriella Matera, Luigino Calzetta, Paola Rogliani, Nicola Hanania, Mario Cazzola
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Efficacy and Safety of Re-administration of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) After EGFR-TKI-Induced Interstitial Lung Disease (CS-Lung-005) Lung (IF 5.0) Pub Date : 2024-01-24 Nobuhiro Kanaji, Eiki Ichihara, Takaaki Tanaka, Takashi Ninomiya, Toshiyuki Kozuki, Nobuhisa Ishikawa, Kazuya Nishii, Hiroyasu Shoda, Kakuhiro Yamaguchi, Keita Kawakado, Yuko Toyoda, Masaaki Inoue, Nobuyuki Miyatake, Naoki Watanabe, Takuya Inoue, Hitoshi Mizoguchi, Yuta Komori, Kazuki Kojima, Norimitsu Kadowaki
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Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study Lung (IF 5.0) Pub Date : 2024-01-22 Duong Duc Pham, Ji-Hyang Lee, Hyouk-Soo Kwon, Woo-Jung Song, You Sook Cho, Hyunkyoung Kim, Jae-Woo Kwon, So-Young Park, Sujeong Kim, Gyu Young Hur, Byung Keun Kim, Young-Hee Nam, Min-Suk Yang, Mi-Yeong Kim, Sae-Hoon Kim, Byung-Jae Lee, Taehoon Lee, So-Young Park, Min-Hye Kim, Young-Joo Cho, ChanSun Park, Jae-Woo Jung, Han Ki Park, Joo-Hee Kim, Ji-Yong Moon, Pankaj Bhavsar, Ian Adcock, Kian Fan Chung
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Elevated Eosinophil Counts in Acute Exacerbations of Bronchiectasis: Unveiling a Distinct Clinical Phenotype Lung (IF 5.0) Pub Date : 2024-01-16 Weixin Chen, Siyi Ran, Chenchang Li, Zhixin Li, Nili Wei, Jing Li, Naijian Li
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Mucus Transpiration as the Basis for Chronic Cough and Cough Hypersensitivity Lung (IF 5.0) Pub Date : 2023-12-22
Abstract Chronic cough is characterized by a state of cough hypersensitivity. We analyze the process of transpiration, by which water appears to evaporate from laryngeal and tracheal mucus as from the surface of a leaf, as a potential cause of cough hypersensitivity. In this process, osmotic pressure differences form across mucus, pulling water toward the air, and preventing mucus dehydration. Recent
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Transbronchial Lung Cryobiopsy Performed with Cone Beam Computed Tomography Guidance Versus Fluoroscopy: A Retrospective Cohort Review Lung (IF 5.0) Pub Date : 2023-12-21 Syed O. Ali, Carson Castellani, Bryan S. Benn
Purpose Determining the cause of interstitial lung disease (ILD) remains challenging. While surgical lung biopsy remains the gold standard approach, risks associated with it may be prohibitive. Transbronchial lung cryobiopsy (TBLC) is a minimally invasive alternative with an improved safety profile and acceptable diagnostic accuracy. We retrospectively assessed whether the use of Cone Beam computed
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The Therapeutic Landscape in Chronic Cough Lung (IF 5.0) Pub Date : 2023-12-21
Abstract In recent years, there has been a substantial increase in the development of antitussive therapies and the first new therapy, gefapixant has been licenced in Europe. This review describes current unlicenced treatments for chronic cough and details treatments currently in development for refractory chronic cough and cough in idiopathic pulmonary fibrosis, as well as compounds previously explored
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Osteopontin: A Novel Therapeutic Target for Respiratory Diseases Lung (IF 5.0) Pub Date : 2023-12-07 Qi Jia, Yeling Ouyang, Yiyi Yang, Shanglong Yao, Xiangdong Chen, Zhiqiang Hu
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Diaphragm Ultrasonography: Reference Values and Influencing Factors for Thickness, Thickening Fraction, and Excursion in the Seated Position Lung (IF 5.0) Pub Date : 2023-11-29 Toru Yamada, Taro Minami, Syumpei Yoshino, Ken Emoto, Suguru Mabuchi, Ryoichi Hanazawa, Akihiro Hirakawa, Masayoshi Hashimoto
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Predictors of Initial CPAP Prescription and Subsequent Course with CPAP in Patients with Central Sleep Apneas at a Single Center Lung (IF 5.0) Pub Date : 2023-11-21 Brian W. Locke, Jeffrey Sellman, Jonathan McFarland, Francisco Uribe, Kimberly Workman, Krishna M. Sundar
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Illuminating Airway Nerve Structure and Function in Chronic Cough Lung (IF 5.0) Pub Date : 2023-11-21 James Kornfield, Ubaldo De La Torre, Emily Mize, Matthew G. Drake
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Chronic Cough as a Genetic Neurological Disorder? Insights from Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS) Lung (IF 5.0) Pub Date : 2023-11-18 Richard D. Turner, Barnaby Hirons, Andrea Cortese, Surinder S. Birring
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Pulmonary Function and Quality of Life in Adults with Cystic Fibrosis Lung (IF 5.0) Pub Date : 2023-11-16 Natalia Smirnova, Jane Lowers, Matthew J. Magee, Sara C. Auld, William R. Hunt, Anne Fitzpatrick, Vibha Lama, Dio Kavalieratos
Purpose People living with cystic fibrosis (CF) experience impaired quality of life, but the extent to which pulmonary function is associated with quality of life in CF remains unclear Methods Using baseline data from a trial of specialist palliative care in adults with CF, we examined the association between pulmonary obstruction and quality of life (measured with the Functional Assessment of Chronic
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Lung Cancer in Never Smokers: Delving into Epidemiology, Genomic and Immune Landscape, Prognosis, Treatment, and Screening Lung (IF 5.0) Pub Date : 2023-11-16 Ayse Ece Cali Daylan, Emily Miao, Kevin Tang, Grace Chiu, Haiying Cheng
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Methotrexate Polyglutamate Concentrations as a Possible Predictive Marker for Effectiveness of Methotrexate Therapy in Patients with Sarcoidosis: A Pilot Study Lung (IF 5.0) Pub Date : 2023-11-16 Montse Janssen Bonás, Janani Sundaresan, Ruth G. M. Keijsers, Eduard A. Struys, Bas J. M. Peters, Vivienne Kahlmann, Marlies S. Wijsenbeek, Maurits C. F. J. de Rotte, Jan C. Grutters, Marcel Veltkamp
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MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary Fibrosis Lung (IF 5.0) Pub Date : 2023-11-16 Yali Fan, Chunming Zheng, Ruimin Ma, Jingwei Wang, Shuqiao Yang, Qiao Ye
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A Clinical Decision Tool for Risk Stratifying Patients with Systemic Sclerosis-Related Pulmonary Hypertension Lung (IF 5.0) Pub Date : 2023-11-13 Justin K. Lui, Kari R. Gillmeyer, Ruchika A. Sangani, Robert J. Smyth, Deepa M. Gopal, Marcin A. Trojanowski, Andreea M. Bujor, Renda Soylemez Wiener, Michael P. LaValley, Elizabeth S. Klings
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Recurrent Cough in the Elderly: A Forgotten Entity Lung (IF 5.0) Pub Date : 2023-11-14 Johanna Tuulikki Kaulamo, Anne Marika Lätti, Heikki Olavi Koskela
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An Artificial Intelligence Platform for the Radiologic Diagnosis of Pulmonary Sarcoidosis: An Initial Pilot Study of Chest Computed Tomography Analysis to Distinguish Pulmonary Sarcoidosis from a Negative Lung Cancer Screening Scan Lung (IF 5.0) Pub Date : 2023-11-14 Marc A. Judson, Jianwei Qiu, Camille L. Dumas, Jun Yang, Brion Sarachan, Jhimli Mitra
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Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH Mitigates Acute Murine Lung Allograft Rejection Lung (IF 5.0) Pub Date : 2023-11-07 Ye Cui, Zhe Lv, Zeran Yang, Jianfeng Lei
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Assessment and Management of Cough in Idiopathic Pulmonary Fibrosis: A Narrative Review Lung (IF 5.0) Pub Date : 2023-11-07 Shangxiang Liu, Xu Ye
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Predictive Value of CT Biomarkers in Lung Transplantation Survival: Preliminary Investigation in a Diverse, Underserved, Urban Population Lung (IF 5.0) Pub Date : 2023-11-02 Renee S. Friedman, Anna Tarasova, Vineet R. Jain, Kenny Ye, Ali Mansour, Linda B. Haramati
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Prognostic Impact of Cancer Inflammation Prognostic Index for Non-small Cell Lung Cancer Lung (IF 5.0) Pub Date : 2023-10-31 Nozomu Motono, Takaki Mizoguchi, Masahito Ishikawa, Shun Iwai, Yoshihito Iijima, Hidetaka Uramoto
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Feasibility and Utility of a Smartphone Application-Based Longitudinal Cough Monitoring in Chronic Cough Patients in a Real-World Setting Lung (IF 5.0) Pub Date : 2023-10-13 Seung-Eun Lee, Matthew Rudd, Tae-Hwa Kim, Ji-Yoon Oh, Ji-Hyang Lee, Lola Jover, Peter M. Small, Kian Fan Chung, Woo-Jung Song
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Targeting CDH17 with Chimeric Antigen Receptor-Redirected T Cells in Small Cell Lung Cancer Lung (IF 5.0) Pub Date : 2023-10-12 Wen Tian, Jinhui Zhao, Wenzhong Wang
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Lung Microbiome as a Treatable Trait in Chronic Respiratory Disorders Lung (IF 5.0) Pub Date : 2023-09-26 Filippo Scialò, Maria Vitale, Vito D’Agnano, Domenica Francesca Mariniello, Fabio Perrotta, Alice Castaldo, Susan F. M. Campbell, Lucio Pastore, Mario Cazzola, Andrea Bianco
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Current Applications of Artificial Intelligence in Sarcoidosis Lung (IF 5.0) Pub Date : 2023-09-20 Dana Lew, Eyal Klang, Shelly Soffer, Adam S. Morgenthau
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Increased Fungal Infection Mortality Induced by Concurrent Viral Cellular Manipulations Lung (IF 5.0) Pub Date : 2023-09-05 Kevin Roe
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Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study Lung (IF 5.0) Pub Date : 2023-09-02 Eun-Jung Jo, Ji-Hyang Lee, Ha-Kyeong Won, Noeul Kang, Sung-Yoon Kang, Seung Eun Lee, Ji-Ho Lee, Mi-Yeong Kim, Ji-Su Shim, Jin An, Youngsang Yoo, So-Young Park, Byung-Keun Kim, Ji-Yong Moon, Han-Ki Park, Min-Hye Kim, Hyouk-Soo Kwon, Sae-Hoon Kim, Sang-Heon Kim, Yoon-Seok Chang, Sang-Hoon Kim, Surinder S. Birring, Byung-Jae Lee, Woo-Jung Song
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Genetic Association of Circulating Adipokines with Risk of Idiopathic Pulmonary Fibrosis: A Two-Sample Mendelian Randomization Study Lung (IF 5.0) Pub Date : 2023-08-02 Dong Huang, Linjing Gong, Zhenru Wu, Yujun Shi, Zongan Liang
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Investigation of Early-Stage Non-Small Cell Lung Cancer Patients with Different T2 Descriptors: Real Word Data From a Large Database Lung (IF 5.0) Pub Date : 2023-07-24 Jing-Sheng Cai, Xun Wang
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ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis Lung (IF 5.0) Pub Date : 2023-07-25 Min Yang, Yanping Chen, Xueshan Huang, Fang Shen, Yanni Meng
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Early Detection of Aspergillus Species in Lower Respiratory Tract is Associated with Higher Mortality in Viral Community-Acquired Pneumonia: A Multicenter Prospective Cohort Study in China Lung (IF 5.0) Pub Date : 2023-07-22 Lu Yin, Ying Zhang, Yali Zheng, Qiongzhen Luo, Lili Zhao, Wentao Ni, Yu Xu, Zhancheng Gao
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Association of World Trade Center (WTC) Occupational Exposure Intensity with Chronic Obstructive Pulmonary Disease (COPD) and Asthma COPD Overlap (ACO) Lung (IF 5.0) Pub Date : 2023-07-19 Rafael E. de la Hoz, Moshe Shapiro, Anna Nolan, Akshay Sood, Roberto G. Lucchini, James E. Cone, Juan C. Celedón
Introduction Reported associations between World Trade Center (WTC) occupational exposure and chronic obstructive pulmonary disease (COPD) or asthma COPD overlap (ACO) have been inconsistent. Using spirometric case definitions, we examined that association in the largest WTC occupational surveillance cohort. Methods We examined the relation between early arrival at the 2001 WTC disaster site (when
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Analytic Morphomics in Myositis-Related Interstitial Lung Disease Lung (IF 5.0) Pub Date : 2023-07-17 Alexander T. O’Mahony, Patrick J. Henry, Patrick Coghlan, Michael Waldron, Claire Crowley, David Ryan, Niamh Moore, Deirdre M. Bennett, Owen J. O’Connor, Michael M. Maher, Michael T. Henry
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A Longitudinal Study of Respiratory Mechanics in Pregnant Women with Obesity and Overweight Lung (IF 5.0) Pub Date : 2023-07-08 Ghada Bourjeily, Laura Sanapo, Geralyn Messerlian, Margaret H. Bublitz, Beth Hott, Melissa Guillen, Annaly Aldana, Ashanti Avalos, Tamara Sequeira, Cheryl Felber, Cynthia Brosnan, Talal El Zarif, F. Dennis McCool
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Collagen Type IV Alpha 5 Chain in Bronchiolitis Obliterans Syndrome After Lung Transplant: The First Evidence Lung (IF 5.0) Pub Date : 2023-07-04 M. Armati, S. Cattelan, M. Guerrieri, M. Messina, B. Perea, M. Genovese, M. d’Alessandro, S. Gangi, P. Cameli, F. Perillo, D. Bennett, A. Fossi, E. Bargagli, L. Bergantini
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Whole Genome Sequencing in Advanced Lung Cancer can be Performed Using Diff-Quik Cytology Smears Derived from Endobronchial Ultrasound, Transbronchial Needle Aspiration (EBUS TBNA) Lung (IF 5.0) Pub Date : 2023-07-05 David Fielding, Andrew J. Dalley, Mahendra Singh, Lakshmy Nandakumar, Vanessa Lakis, Haarika Chittoory, David Fairbairn, Kaltin Ferguson, Farzad Bashirzadeh, Michael Bint, Carl Pahoff, Jung Hwa Son, Alan Hodgson, John V. Pearson, Nicola Waddell, Sunil R. Lakhani, Gunter Hartel, Katia Nones, Peter T. Simpson
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Lactate Dehydrogenase and Hemorrhagic Stroke During Extracorporeal Membrane Oxygenation for COVID-19 Lung (IF 5.0) Pub Date : 2023-07-04 Jose I. Nunez, Mayuko Uehara, Amira Mohamed, Nicholas Mellas, Justin E. Ashley, Marjan Rahmanian, Anthony Carlese, Stephen J. Forest, Daniel Goldstein, Ulrich Jorde, Omar Saeed
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The Relationship Between Serum Angiotensin Converting Enzyme Level and the Decision to Escalate Treatment of Sarcoidosis Lung (IF 5.0) Pub Date : 2023-06-27 Boris Shkolnik, Rou Sore, Muhammad Salick, Gowthami Kobbari, Sana Ghalib, Anoosh S. Parimi, Kenneth M. Fish, Robert Deluca, Recai Yucel, Marc A. Judson
Purpose We performed a retrospective analysis of a sarcoidosis cohort who had sACE obtained at their initial clinic visit, but the treating physician was blinded to the results. We examined the relationship between sACE and the treating physician’s decision to escalate sarcoidosis treatment. Methods Treatment was considered escalated if the prednisone dose was increased or if the prednisone dose was
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Improved Survival of IPF patients Treated With Antifibrotic Drugs Compared With Untreated Patients Lung (IF 5.0) Pub Date : 2023-06-21 Mark G. J. P. Platenburg, Coline H. M. van Moorsel, Ivo A. Wiertz, Joanne J. van der Vis, Adriane D. M. Vorselaars, Marcel Veltkamp, Jan C. Grutters
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The Relationship Between Sarcoidosis Organ Involvement, Environment, Race, and Genetics: There's a Signal, But Fine Tuning Is Needed. Lung (IF 5.0) Pub Date : 2023-06-15 Marc A Judson
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Multiple Correspondence Analysis and HLA-Associations of Organ Involvement in a Large Cohort of African-American and European-American Patients with Sarcoidosis Lung (IF 5.0) Pub Date : 2023-06-15 Astrid Rasmussen, Bryan A. Dawkins, Chuang Li, Nathan Pezant, Albert M. Levin, Benjamin A. Rybicki, Michael C. Iannuzzi, Courtney G. Montgomery
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Static Respiratory System Compliance as a Predictor of Extubation Failure in Patients with Acute Respiratory Failure Lung (IF 5.0) Pub Date : 2023-06-10 Lauren A. Abplanalp, Filip Ionescu, Enrique Calvo-Ayala, Limin Yu, Girish B. Nair
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Efficacy and Safety of Eliapixant in Refractory Chronic Cough: The Randomized, Placebo-Controlled Phase 2b PAGANINI Study Lung (IF 5.0) Pub Date : 2023-06-01 Peter V. Dicpinigaitis, Alyn H. Morice, Jaclyn A. Smith, Mandel R. Sher, Michael Vaezi, Laurent Guilleminault, Akio Niimi, Kerstin Gude, Ulrike Krahn, Riitta Saarinen, Philippe Vieira Pires, Melanie Wosnitza, Lorcan McGarvey