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An in vitro study of metformin adsorption to activated charcoal Clin. Toxicol. (IF 3.3) Pub Date : 2024-04-22 Yoshinori Tomoda, Masahiro Kobayashi
Metformin is a biguanide used to manage patients with type 2 diabetes mellitus. However, metabolic acidosis with an elevated lactate concentration and death caused by metformin overdoses are toxico...
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Response to Özdemir O on “Kounis syndrome due to remdesivir allergy” Clin. Toxicol. (IF 3.3) Pub Date : 2024-04-19 Eirini Beneki, Kyriakos Dimitriadis, Alexandros Antonopoulos, Konstantina Aggeli, Konstantinos Tsioufis
Published in Clinical Toxicology (Ahead of Print, 2024)
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Increasing severity of medical outcomes and associated substances in cases reported to United States poison centers Clin. Toxicol. (IF 3.3) Pub Date : 2024-04-18 Rita Farah, Ryan J. Cole, Christopher P. Holstege
Poison centers provide free expert recommendations on the treatment of a wide variety of toxicological emergencies. Prior studies have called attention to the increasing complexity of cases reporte...
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Toxic epidermal necrolysis associated with the use of levetiracetam Clin. Toxicol. (IF 3.3) Pub Date : 2024-04-15 Yamile Sierra-Gordillo, Elkin Peñaranda-Contreras, Margarita M. Gomez Arbeláez, Paula A. Moreno-Lucero
Published in Clinical Toxicology (Ahead of Print, 2024)
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Common pitfalls in the use of hypertonic sodium bicarbonate for cardiac toxic drug poisonings Clin. Toxicol. (IF 3.3) Pub Date : 2024-04-10 Betty S. Chan, Nicholas A. Buckley
Hypertonic sodium bicarbonate is advocated for the treatment of sodium channel blocker poisoning, but its efficacy varies amongst different sodium channel blockers. This Commentary addresses common...
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Impact of social media “challenges” on poison center case volume for intentional ingestions among school-aged children: an observational study Clin. Toxicol. (IF 3.3) Pub Date : 2024-04-08 Rebecca D. Marshall, Jessica Bailey, Amber Lin, David C. Sheridan, Robert G. Hendrickson, Adrienne Hughes, B. Zane Horowitz
Mental health problems among youth have escalated over the past decade, with increased rates of self-harm, including suicide attempts by ingestion. Social media use has been linked to youth mental ...
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Gastric perforation after polyurethane foam ingestion Clin. Toxicol. (IF 3.3) Pub Date : 2024-04-08 Ki Bum Park, Woo Young Nho, Byunghyuk Yu, Jungbae Park
Acute intoxication rarely produces conditions that require urgent surgical care.A 45-year-old man presented to the emergency department with severe abdominal pain after the deliberate ingestion of ...
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Paramao root oil: a novel culprit in salicylate poisoning Clin. Toxicol. (IF 3.3) Pub Date : 2024-04-05 Bashir Chakar, Sarah Kabir, Chianna Dane, Nicholas Proschogo, Andrew Dawson
Published in Clinical Toxicology (Ahead of Print, 2024)
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Use of point-of-care ultrasound to assess the severity of scorpion stings in hospitalized patients Clin. Toxicol. (IF 3.3) Pub Date : 2024-04-02 Juliana Sartorelo Almeida, Cecilia Gomez Ravetti, Marcus Vinícius de Melo Andrade, Adebal de Andrade Filho, Rafael Silva e Castro, Pedro Pires Costa Pimenta, Paula Frizera Vassallo, Vandack Nobre
Scorpionism is a public health problem, especially in tropical regions. In Brazil, the prevalence of envenomation by scorpions is high, and the average national lethality is around 0.16 percent. Th...
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Trimeresurus insularis (blue Indonesian pit viper) envenomation treated with Thai green pit viper antivenom Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-25 Ryan Feldman, Matthew Stanton, Justin Corcoran, Kristin Bialkowski, Jillian Theobald, David Gummin
Published in Clinical Toxicology (Ahead of Print, 2024)
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Assessing the impact of a new medical toxicology service on the treatment of paracetamol overdose at a large tertiary care hospital Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-25 Eli Bronshtein, Or Segev, Dennis Scolnik, Miguel Glatstein
Paracetamol overdose is the most common cause of acute liver failure in the United States. Administration of acetylcysteine is the standard of care for this intoxication. Laboratory values and clin...
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Clinical outcomes associated with orphenadrine deliberate self-poisoning: a retrospective poisons centre study Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-25 Nina Dhaliwal, Darren M. Roberts
Orphenadrine overdoses can cause antimuscarinic toxicity, respiratory failure, refractory seizures and cardiotoxicity. The dose–toxicity relationship is poorly defined. Orphenadrine is marketed as ...
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Intratracheal cobinamide (vitamin B12 analog) administration increases survivability in rabbits exposed to a lethal dose of inhaled hydrogen sulfide Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-21 Seungyong Park, David Mukai, Jangweon Lee, Tanya Burney, Gerry Boss, Phillipe Haouzi, Jane Annabelle Lee, Mark Thomas Kim, Alexis Makenna Fox, George Philipopoulos, Matthew Brenner
Hydrogen sulfide is a highly toxic, flammable, and colorless gas. Hydrogen sulfide has been identified as a potential terrorist chemical threat agent in mass-casualty events. Our previous studies s...
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Ototoxicity following direct inner ear exposure to metallic mercury Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-19 Petros V. Vlastarakos, Ilias A. Lazarou, Evangelos Panagoulis, Giorgos Sideris
Published in Clinical Toxicology (Ahead of Print, 2024)
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Delayed cardiac arrest after hydrofluoric acid ingestion Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-19 J. A. Kroes, J. M. H de Haan, M. I. de Haan-Lauteslager, E. N. van Roon, S. J. Derksen, E. R. Manusama, G. J. Zijlstra, S. S. Gisbertz, B. E. L Vrijsen, C. Bethlehem
Published in Clinical Toxicology (Ahead of Print, 2024)
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Self-medication cases reported to a poison information center in Brazil from 2014 to 2020 Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-19 Franthesco Niccolas Bertote Guarda, Isabela Nucci Galetti, Claudia Regina dos Santos, Camila Marchioni
Self-medication is the use of drugs to treat self-diagnosed illnesses or symptoms, on one’s own initiative, without the guidance of a healthcare professional. Poison centers play an important role ...
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Dipentylone: a novel synthetic cathinone in Spain’s illicit drug landscape. Findings in a clinical toxicology laboratory Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-15 Gonzalo Verdú, María Rodríguez García, Eva Martínez, Lourdes Marés, Edgar Martín, Jordi To-Figueras, Emilio Salgado, Mercè Brunet, Marina Parra-Robert
Published in Clinical Toxicology (Ahead of Print, 2024)
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Ingestion of heated tobacco sticks containing a micro-blade by children: the importance of performing a radiograph Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-13 Azzurra Schicchi, Davide Lonati, Anna Papotto, Annamaria Ippolito, Sebastiano Piana, Santo Grasso
Some tobacco sticks, such as TEREA™ heat sticks for IQOS ILUMA™, contain a blade. Both the nicotine part of the device and the micro-blade can be ingested by children.We report two children, an 18-...
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Challenges with glucagon-like peptide-1 (GLP-1) agonist initiation: a case series of semaglutide overdose administration errors Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-12 Brian G. Wiener, Marlis Gnirke, Susi Vassallo, Silas W. Smith, Mark K. Su
Prescriptions of semaglutide, a glucagon-like peptide-1 receptor agonist administered weekly for Type 2 diabetes mellitus and obesity, are increasing. Adverse effects from semaglutide overdose are ...
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Optic nerve sheath diameter measurements to predict delayed neurological sequelae after carbon monoxide poisoning Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-11 Yusuf Kenan Tekin
Delayed neurological sequelae are a major complication of carbon monoxide poisoning. However, today there is still no objective screening tool for predicting delayed neurological sequelae in patien...
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Commiphora myrrha acute toxicity Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-11 Marwa M. Fouad, Nermin H. Zawilla, Ahmed Maher
Published in Clinical Toxicology (Vol. 62, No. 2, 2024)
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The Clinical Toxicology Recommendations Collaborative: purpose, organization, and methodology Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-11 Martin F. Wilks, Christopher Hoyte, Kirk L. Cumpston, Hossein Hassanian-Moghaddam, Man-Li Tse, Ana Ferrer-Dufol, Horst Thiermann
Scientific societies aim to provide a collective voice and unified stance on important issues. The Clinical Toxicology Recommendations Collaborative was formed in 2016 to develop evidence- and cons...
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Fomepizole use reported to United States Poison Centers from 2010 to 2021 Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-11 James B. Leonard, Faisal S. Minhaj, Kennedy Erickson, Joshua King
The diagnosis of toxic alcohol poisoning is often based on clinical presentation and nonspecific surrogate laboratory studies due to limited testing availability. Fomepizole is the recommended anti...
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Rivastigmine for the management of anticholinergic delirium Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-11 Angela L. Chiew, Amanda G. Holford, Betty S. H. Chan, Katherine Z. Isoardi
Anticholinergic agents are commonly taken in overdose, often causing delirium. The spectrum of anticholinergic delirium ranges from mild agitation to severe behavioural disturbance. Physostigmine i...
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Public health risk due to contamination of Solanum nigrum in frozen green beans – collaboration effort between a poison centre, a hospital and health authorities Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-07 Chantal Roelen, Henneke N. Mulder-Spijkerboer, Eleanor S.I Gee, Pinar Kolukirik, Els G. Biesta-Peters, Hilde Royen
We describe a rare food contamination of organically grown frozen green beans with Solanum nigrum, also called black night shade, which were widely available in supermarkets in the Netherlands.To o...
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Survival after chlorfenapyr intoxication by non-gastrointestinal route Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-06 Ya-qing An, Yan-ling Dong, Shu-na Hao, Hao Xiao, Ying-ping Tian, Yu Gong
Published in Clinical Toxicology (Vol. 62, No. 2, 2024)
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Sex differences in the susceptibility to valproic acid-associated liver injury in epileptic patients Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-04 Linfeng Ma, Dan Wang
Valproic acid has been widely used as an antiepileptic drug for several decades. Long-term valproic acid treatment is usually accompanied by liver injury. Although both men and women are susceptibl...
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Comparison of the new-Poisoning Mortality Score and the Modified Early Warning Score for predicting in-hospital mortality in patients with acute poisoning Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-29 Sijin Lee, Su Jin Kim, Kap Su Han, Juhyun Song, Sung Woo Lee
The evaluation of acute poisoning is challenging due to varied toxic substances and clinical presentations. The new-Poisoning Mortality Score was recently developed to assess patients with acute po...
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Hexahydrocannabinol poisoning reported to French poison centres Clin. Toxicol. (IF 3.3) Pub Date : 2024-03-01 Magali Labadie, Audrey Nardon, Nadège Castaing, Coralie Bragança, Amélie Daveluy, Jean-Michel Gaulier, Souleiman El Balkhi, Marike Grenouillet, French Poison Centre Research Group, Christine Tournoud
Hexahydrocannabinol is a hexahydro derivative of cannabinol. Poisoning with hexahydrocannabinol was first observed in Europe in May 2022.This is a retrospective observational study of cases of self...
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Accuracy and replicability of identifying eyelid tremor as an indicator of recent cannabis smoking Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-29 George Sam Wang, Michael Kosnett, Prem Subramanian, Julia Wrobel, Ming Ma, Tim Brown, L. Cinnamon Bidwell, Ashley Brooks-Russell
Cannabis intoxication may increase the risk of motor vehicle crashes. However, reliable methods of assessing cannabis intoxication are limited. The presence of eyelid tremors is among the signs of ...
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Risk factors for deliberate self-poisoning among children and adolescents in The Netherlands Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-29 Ilze M. J. Thoonen, Saskia J. Rietjens, Agnes G. van Velzen, Dylan W. de Lange, Arjen Koppen
In the past decade, the number of deliberate self-poisonings involving young people has increased strongly worldwide. This study aimed to gain insight into risk factors associated with deliberate s...
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Oral potassium poisoning: a retrospective review of the National Poison Data System 2010–2021 Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-29 Rita Farah, Joseph E. Carpenter, Brent W. Morgan
Oral potassium poisoning can be life-threatening. The study aimed to describe patterns of oral potassium poisoning in adult and pediatric populations and characterize its clinical presentation and ...
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Clinical Toxicology Expert Reviewers 2023 Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-29
Published in Clinical Toxicology (Vol. 62, No. 1, 2024)
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Correction Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-29
Published in Clinical Toxicology (Vol. 62, No. 2, 2024)
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Exposure to ammonia solution due to substance use: a retrospective study from the French poison centres database (2009–2018) Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-28 Aurore Czerwiec, Cecile Chevallier, Guillaume Grenet, Anne-Marie Patat, Sander de Souza, Jeanne Lichtfouse, French Poison Centres Research Group, Alexandra Boucher, Nathalie Paret
Ammonia solution (ammonium hydroxide) is used to convert cocaine hydrochloride to freebase cocaine. Due to its causticity, unintentional exposure to ammonia in a substance use context can result in...
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Effects of interrupting the enterohepatic circulation in amatoxin intoxications Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-27 Jurriaan Varekamp, Jia Lin Tan, Janine Stam, Aad P. van den Berg, Patrick F. van Rheenen, Daan J. Touw, Bart G. J. Dekkers
Interruption of the enterohepatic circulation is regarded as an effective way to treat patients with amatoxin poisoning. Nonetheless, its effectiveness has not yet been systematically evaluated. Th...
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Comment on “Students’ perceptions of ToxicolitaireTM– a digital card game for medical toxicology students” Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-23 Janice Shin-Kim, Adam Blumenberg
Published in Clinical Toxicology (Vol. 62, No. 2, 2024)
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Evaluation of the relationship of xylazine and fentanyl blood concentrations among fentanyl-associated fatalities Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-14 Hannah L. Hays, Henry A. Spiller, Rebecca T. DeRienz, Natalie I. Rine, Han-Tian Guo, Meagan Seidenfeld, Nichole L. Michaels, Gary A. Smith
Illicit fentanyl and fentanyl-analogs have produced a devastating increase in opioid fatalities in the United States. Increasingly, xylazine has been found in the illicit fentanyl supply. The role ...
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N-desethyl isotonitazene detected in polydrug users admitted to hospital in Birmingham, United Kingdom Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-14 Mark Pucci, Gurpreet Singh Jutley, Jonathan Looms, Loretta Ford
Nitazenes are potent synthetic opioids and N-desethyl isotonitazene, a metabolite of isotonitazene, has emerged as a drug in its own right.This is an observational case series of patients with susp...
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Death of Socrates: a likely case of poison hemlock (Conium maculatum) poisoning Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-13 Anthony D. Dayan
The death of Socrates in 399 BCE is described in Plato’s dialogue, the Phaedo, written an unknown time afterwards from accounts by others.Socrates’ death has almost always been attributed to his dr...
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The role of QRS complex prolongation in predicting severe toxicity in single-xenobiotic overdose Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-08 Mark Simon, Sabrina Kaplan, Karen Muschler, Christopher Hoyte, Jeffrey Brent
The QRS complex duration is commonly used to prognosticate severity, predict outcomes, and indicate treatment in overdose. However, literature to support this practice is mixed in tricyclic antidep...
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Students’ perceptions of Toxicolitaire™– a digital card game for medical toxicology students Clin. Toxicol. (IF 3.3) Pub Date : 2024-02-01 Carine Marks, Catharina Du Plessis, Daniël J. van Hoving
Toxicology students are frequently overwhelmed by the volume and complexity of information. To enhance the learning experience, medical toxicology lecturers created a digital card game named Toxico...
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Clinical effects of occupational clonidine poisoning and efficacy of extracorporeal blood purification therapies Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-26 Shan Wu, Bo Han, Xishan Xiong
Published in Clinical Toxicology (Vol. 62, No. 1, 2024)
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An attempted homicidal poisoning with bromadiolone Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Kristy J. McCulloch, Yu Chen, Jyh-Pyng Gau, Chen-Chang Yang, Katherine Z. Isoardi
Published in Clinical Toxicology (Vol. 61, No. 12, 2023)
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Closing the xylazine knowledge gap Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Robert S. Hoffman
Published in Clinical Toxicology (Vol. 61, No. 12, 2023)
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Management of button battery ingestion Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Angela L. Chiew, Betty S. H. Chan
Published in Clinical Toxicology (Vol. 61, No. 12, 2023)
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Pre-hospital triage of children at risk of oesophageal button battery impaction: the button battery impaction score Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Jules-Antoine Vaucel, Cédric Gil-Jardine, Camille Paradis, Raphael Enaud, Magali Labadie
Button battery ingestion in children can be fatal if oesophageal perforation occurs. Such children require chest radiography in the emergency department to determine the button battery position and...
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Fifty years of paracetamol (acetaminophen) poisoning: the development of risk assessment and treatment 1973–2023 with particular focus on contributions published from Edinburgh and Denver Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 D. Nicholas Bateman, Richard C. Dart, James W. Dear, Laurie F. Prescott, Barry H. Rumack
Fifty years ago, basic scientific studies and the availability of assay methods made the assessment of risk in paracetamol (acetaminophen) poisoning possible. The use of the antidote acetylcysteine...
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Valacyclovir neurotoxicity and kinetics in a patient with impaired kidney function Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Bradley Ryan, Jagarlamudi Bhashitaa, Angela L. Chiew, Betty S. Chan
Published in Clinical Toxicology (Vol. 61, No. 12, 2023)
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Methanol poisonings from contaminated hand sanitizers identified by the United States Food and Drug Administration Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Karen Konkel, Keith Burkhart, Carmen Cheng, Regina Lee, Theresa Michele, Evelyn Mentari, Ida-Lina Diak, Lynda MCCulley
Published in Clinical Toxicology (Vol. 61, No. 12, 2023)
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Kounis syndrome associated with remdesivir therapy in a COVID-19 patient Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Eirini Beneki, Kyriakos Dimitriadis, Alexandros Antonopoulos, Konstantina Aggeli, Konstantinos Tsioufis
Published in Clinical Toxicology (Vol. 61, No. 12, 2023)
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Insulin-euglycemia therapy in acute aluminum phosphide poisoning: a randomized clinical trial Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Basma Adel, Nashwa Mohamed Elgharbawy, Marwa Mohamed Shahin, Arwa Ahmed Abo-Elfadl, Khaled Mahmoud Saad
Introduction: Aluminum phosphide is a pesticide that is used in developing countries. Aluminum phosphide poisoning has a high mortality rate and there is no known antidote. This study aimed to eval...
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An intravenous paracetamol overdose in an eight-day-old neonate Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Arjen Koppen, Cecile H. J. Bekkers, Gordon H. P. R. Slabbers, Dylan W. de Lange, Robbert B. T. Verkooijen
Published in Clinical Toxicology (Vol. 61, No. 12, 2023)
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A fatal case of polyoxyethylated-p-nonylphenol surfactant (Wetter 600) ingestion Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Keith Harris, Jack Garland, Katherine Z. Isoardi
Published in Clinical Toxicology (Vol. 61, No. 12, 2023)
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Bombé, an undetermined substance that caused an outbreak of illicit drug use in Kinshasa, Democratic Republic of the Congo Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Paul Musa Obadia, Patrice Milambo Kapia, Arne Bonneure, Radu-Corneliu Duca, Matteo Creta, Tony Kayembe-Kitenge, Jan Tytgat, Daniel Okitundu, Célestin Banza Lubaba Nkulu, Benoit Nemery
Illegal drugs are becoming a public health problem in African cities. In 2021, Bombé, a new drug of unknown composition, caused an outbreak of neuro-psychiatric symptoms in Kinshasa. Bombé was rumo...
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Diffusion-weighted imaging in methanol poisoning: beyond the lentiform fork sign Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-17 Yan Yang, Hongwei Zhao
Methanol poisoning is a life-threatening emergency, in which the presence of a lentiform fork sign on magnetic resonance imaging, although not exclusive to methanol poisoning, can be of diagnostic ...
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Succimer chelation in a patient with mercury-associated parkinsonism Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-12 Wen-Ching Chen, Yen-Chen Wu, Poyin Huang
Published in Clinical Toxicology (Vol. 62, No. 1, 2024)
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Ingestion of tartar emetic (antimony potassium tartrate) Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-08 Alicia Everton, Lindsey Smith, Grant Houselog, Joshua Trebach
Published in Clinical Toxicology (Vol. 61, No. 12, 2023)
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Correction Clin. Toxicol. (IF 3.3) Pub Date : 2024-01-08
Published in Clinical Toxicology (Vol. 62, No. 1, 2024)
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Correction Clin. Toxicol. (IF 3.3) Pub Date : 2023-12-19
Published in Clinical Toxicology (Vol. 61, No. 11, 2023)