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Updated ACVIM consensus statement on equine herpesvirus-1 J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-18 David P. Lunn, Brandy A Burgess, David C. Dorman, Lutz S. Goehring, Peggy Gross, Klaus Osterrieder, Nicola Pusterla, Gisela Soboll Hussey
Equine herpesvirus-1 (EHV-1) is a highly prevalent and frequently pathogenic infection of equids. The most serious clinical consequences of infection are abortion and equine herpesvirus myeloencephalopathy (EHM). The previous consensus statement was published in 2009 and considered pathogenesis, strain variation, epidemiology, diagnostic testing, vaccination, outbreak prevention and control, and treatment
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Effects of prednisolone on 1,2-O-dilauryl-rac-glycero glutaric acid-(60-methylresorufin) ester-lipase activity and pancreatic lipase immunoreactivity in healthy cats J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-14 Militsa Pacheva, Daniel Brugger, Barbara Riond, Matthias Dennler, Peter Hendrik Kook
Corticosteroids are among the most commonly used drugs in cats and are increasingly discussed as a treatment for feline pancreatitis. However, its effects on serum lipase in healthy cats remain unknown.
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Prognosis in meningoencephalitis of unknown origin in dogs: Risk factors associated with survival, clinical relapse, and long‐term disability J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-14 Rita Gonçalves, Steven De Decker, Gemma Walmsley, Thomas W. Maddox
BackgroundMeningoencephalitis of unknown origin (MUO) comprises a group of noninfectious inflammatory diseases affecting the central nervous system of dogs. Previous studies have reported individual risk factors for survival but prognostication for MUO remains challenging.ObjectivesIdentify clinical prognostic variables in dogs with MUO.AnimalsA retrospective study of 447 dogs presented to 2 UK referral
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Clinical findings and outcome in goats with discospondylitis and vertebral osteomyelitis J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-14 Alyssa Sullivan, Elodie Huguet, Ashley R. VanderBroek, Shannon Darby, Daniela Luethy
BackgroundVertebral infections, including vertebral osteomyelitis, septic physitis, and discospondylitis, are rarely reported in goats, and when reported, have been largely limited to necropsy case reports.ObjectiveDescribe clinical findings and outcome in goats with vertebral infections evaluated by computed tomography (CT).AnimalsFive goats with vertebral osteomyelitis, septic physitis, and discospondylitis
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Prevalence, clinical presentation, and etiology of myelopathies in 224 juvenile dogs J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-14 Ed J. Pilkington, Steven De Decker, Eleftheria Skovola, Ana Cloquell Miro, Rodrigo Gutierrez Quintana, Kiterie M. E. Faller, Albert Aguilera Padros, Rita Goncalves
BackgroundIntervertebral disc herniation is widely recognized as the most common cause of myelopathy in dogs older than 2 years; however, the prevalence of various causes of myelopathy in younger dogs has not been reported.Hypothesis/ObjectivesTo describe the prevalence, clinical presentation, and etiology of myelopathy in dogs aged 18 months or less. Secondarily, to investigate which clinical features
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Peripheral and intestinal T lymphocyte subsets in dogs with chronic inflammatory enteropathy J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-13 Beatriz Agulla, Alejandra Villaescusa, Ángel Sainz, David Díaz‐Regañón, Fernando Rodríguez‐Franco, Lydia Calleja‐Bueno, Patricia Olmeda, Mercedes García‐Sancho
BackgroundDysregulated T lymphocyte response is thought to play a key role in chronic intestinal inflammation (CIE).ObjectivesTo evaluate the presence of changes in peripheral and intestinal T lymphocyte subsets and to describe potential immune and inflammatory biomarkers in dogs with CIE.AnimalsSixteen healthy dogs and 26 dogs were diagnosed with CIE.MethodsProspective case‐control study evaluating
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Response to letter regarding “Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis” J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-13 Jörg M. Steiner, Chantal Lainesse, Yuya Noshiro, Yumiko Domen, Heather Sedlacek, Stephen E. Bienhoff, Kelly P. Doucette, David L. Bledsoe, Hiroshi Shikama
Thank you for allowing us to respond to the letter to the editor by Allenspach et al. We also thank Dr Allenspach and her co-authors for their comments and presenting us with the opportunity for additional dialog on this important topic. We would first like to state that we by no means were trying to suggest that our study should be the only or definitive study to demonstrate the efficacy of fuzapladib
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Comparison of chemotherapy outcomes between normal and high serum cortisol concentration in dogs with lymphoma J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-13 Hiroki Yamazaki, Kaito Bunbai, Tatsuya Deguchi, Masahiro Tamura, Hiroshi Ohota
BackgroundIncreased serum cortisol (COR) concentrations may induce glucocorticoid resistance by down‐regulation of glucocorticoid receptor (GCR), resulting in decreased chemotherapy efficacy in dogs with lymphoma.HypothesisInvestigate the relationship between serum COR concentrations and chemotherapy outcomes in dogs with lymphoma.AnimalsThirty client‐owned dogs with lymphoma, with serum COR concentration
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Assessment of hemostasis in hyperthyroid and euthyroid cats using two viscoelastic assays and platelet aggregometry J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-11 Daniel Moreno, Kevin Cosford, Elisabeth Snead, Anthony Carr
BackgroundHyperthyroidism in humans is associated with a hypercoagulable state and an increased risk of thromboembolism.ObjectiveTo evaluate hemostatic variables in hyperthyroid and euthyroid cats with the hypothesis that hyperthyroid cats will have evidence of altered hemostasis consistent with a potential hypercoagulable state.AnimalsClient‐owned hyperthyroid (n = 16) and euthyroid (n = 15) cats
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Effect of institutional antimicrobial stewardship guidelines on prescription of critically important antimicrobials for dogs and cats J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-11 Sarah N. Robbins, Robert Goggs, Sydney Kraus‐Malett, Laura Goodman
BackgroundVeterinary hospital antimicrobial stewardship (AMS) guidelines might help combat antimicrobial resistance (AMR).ObjectivesDetermine the conditions and types of infection for which antimicrobial drugs (AMDs) deemed critically important (CIA) by the World Health Organization (WHO) were prescribed and assess the effect of hospital AMS guidelines on adherence to International Society for Companion
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Risk factors and implications associated with ultrasound-diagnosed nephrocalcinosis in cats with chronic kidney disease J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-04 Pak-Kan Tang, Rebecca F. Geddes, Yu-Mei Chang, Rosanne E. Jepson, Dirk Hendrik Nicolaas van den Broek, Nicola Lötter, Jonathan Elliott
Microscopic nephrocalcinosis is a common pathological feature of chronic kidney disease (CKD) in cats. Detection of macroscopic nephrocalcinosis using ultrasonography and its implications remain unexplored.
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Blood pressure in hyperthyroid cats before and after radioiodine treatment J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-05 Lisa Stammeleer, Pilar Xifra, Sara I. Serrano, Mark Rishniw, Sylvie Daminet, Mark E. Peterson
BackgroundHyperthyroid cats commonly have systemic hypertension, with a reported prevalence of 7% to 48%. Although hypertension might be expected to resolve once treatment restores euthyroidism, it can persist or only first develop after treatment.ObjectivesTo determine the proportion of hyperthyroid cats with hypertension (systolic blood pressure [SBP] ≥160 mm Hg), persistence or first development
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Letter regarding “Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis” J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-05 Karin Allenspach, Andreas Handel, Stanley Marks, Peter Kook, Kenny Simpson, Joseph Bartges, Kenjiro Fukushima, Aarti Kathrani, Silke Salavati, Julien Dandrieux, Caroline Mansfield, Alison Manchester, Craig Webb, Valerie Freiche, W. Zane Billings, Jonathan P. Mochel
We read with interest the article by Steiner et al,1 that claims that administration of fuzapladib is safe and effective in reducing 2 clinical scores in dogs with acute pancreatitis (AP). We commend Steiner et al for their efforts in addressing a critical need in veterinary medicine. This letter, however, raises significant concerns regarding the methodology and interpretation of the study results
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Environmental radon, fracking wells, and lymphoma in dogs J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-04 Ashleigh N. Tindle, Samantha L. Braman, Brenna M. Swafford, Lauren A. Trepanier
BackgroundMulticentric lymphoma (ML) in dogs resembles non‐Hodgkin lymphoma (NHL) in humans. Human NHL is associated with multiple environmental exposures, including to radon and volatile organic compounds (VOCs).Hypothesis/ObjectivesThe objective of this study was to determine whether ML in dogs was associated with environmental radon or proximity to horizontal oil and drilling (fracking), a source
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A novel ITGA2B double cytosine frameshift variant (c.1986_1987insCC) leads to Glanzmann's thrombasthenia in a cat J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-01 Victor N. Rivas, Avalene W. K. Tan, Meg Shaverdian, Nghi P. Nguyen, Jalena R. Wouters, Joshua A. Stern, Ronald H. L. Li
BackgroundGlanzmann's thrombasthenia (GT) is a congenital platelet disorder affecting approximately 1:1 000 000 people globally and characterized by impaired platelet aggregation and clot retraction. Autosomal recessive, loss‐of‐function, variants in ITGA2B or ITGB3 of the αIIbβ3 receptor cause the disease in humans. A cat affected by Glanzmann's and macrothrombocytopenia was presented to the UC Davis
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Weishaar's classification system for nodal metastasis in sentinel lymph nodes: Clinical outcome in 94 dogs with mast cell tumor J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-03-01 Damiano Stefanello, Elisa M. Gariboldi, Patrizia Boracchi, Roberta Ferrari, Alessandra Ubiali, Donatella De Zani, Davide D. Zani, Valeria Grieco, Chiara Giudice, Camilla Recordati, Mario Caniatti, Luigi Auletta, Lavinia E. Chiti
BackgroundThe therapeutic role and prognostic relevance of lymphadenectomy in mast cell tumor (MCT) has historically been evaluated on regional rather than sentinel lymph nodes.Hypothesis/ObjectivesTo update information about the association of histological nodal (HN) classes with clinical outcome in dogs with MCT after tumor excision and extirpation of normal‐sized sentinel nodes (SLN) guided by radiopharmaceutical
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Association of a novel dystrophin (DMD) genetic nonsense variant in a cat with X‐linked muscular dystrophy with a mild clinical course J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-28 Harunobu Muto, Yoshihiko Yu, James K. Chambers, Lyndon M. Coghill, Yasuharu Nakamura, Kazuyuki Uchida, Leslie A. Lyons
X‐linked muscular dystrophy in cats (FXMD) is an uncommon disease, with few reports describing its pathogenic genetic variants. A 9‐year‐old castrated male domestic shorthair cat was presented with persistent muscle swelling and breathing difficulty from 3 years of age. Serum activity of alanine aminotransferase, aspartate transaminase, and creatine kinase were abnormally high. Physical and neurological
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Comparison of atlantoaxial and lumbosacral cerebrospinal fluid centesis techniques in South American camelids J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-26 Ester Malmström, Robert C. Cole, Erik H. Hofmeister, Jere K. Stern, Thomas Passler
Iatrogenic blood contamination during cerebrospinal fluid (CSF) centesis is common, which can limit the diagnostic usefulness of the sample. A novel ultrasound-guided CSF collection technique is described in horses, by which CSF is obtained from the atlantoaxial (AA) space.
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Effect of leukoreduction on the metabolism of equine packed red blood cells during refrigerated storage J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-26 Arianna Miglio, Francesca Rocconi, Valentina Cremonini, Angelo D'Alessandro, Julie A. Reisz, Mark Maslanka, Ian S. Lacroix, Giorgio Tiscar, Morena Di Tommaso, Maria T. Antognoni
Understanding of the biochemical and morphological lesions associated with storage of equine blood is limited.
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Relationship between syringomyelia and myxomatous mitral valve disease in Cavalier King Charles spaniels J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-23 Maiken B. T. Bach, Camilla L. Stougaard, Maria S. Thøfner, Maria J. Reimann, Ulrik Westrup, Jørgen Koch, Merete Fredholm, Torben Martinussen, Mette Berendt, Lisbeth H. Olsen
Syringomyelia (SM) and myxomatous mitral valve disease (MMVD) are highly prevalent in Cavalier King Charles spaniels (CKCS). Cardiac status in CKCS with and without SM is currently unknown.
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Pharmacologic interventions for the treatment of equine herpesvirus‐1 in domesticated horses: A systematic review J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-21 Lutz Goehring, David C. Dorman, Klaus Osterrieder, Brandy A. Burgess, Kelsie Dougherty, Peggy Gross, Claire Neinast, Nicola Pusterla, Gisela Soboll‐Hussey, David P. Lunn
BackgroundEquine herpes virus type 1 (EHV‐1) infection in horses is associated with upper respiratory disease, neurological disease, abortions, and neonatal death.Review QuestionDoes pharmacological therapy decrease either the incidence or severity of disease or infection caused by EHV‐1 in domesticated horses?MethodsA systematic review was preformed searching AGRICOLA, CAB s, Cochrane, PubMed, Web
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16th European College of Equine Internal Medicine (ECEIM) Congress J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-21
Lyon, France October 27 to 28, 2023 The European College of Equine Internal Medicine (ECEIM) Congress and the Journal of Veterinary Internal Medicine (JVIM) are not responsible for the content or dosage recommendations in the abstracts. The abstracts are not peer reviewed before publication. The opinions expressed in the abstracts are those of the author(s) and may not represent the views or position
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Automated echocardiographic left ventricular dimension assessment in dogs using artificial intelligence: Development and validation J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-16 Catherine C. Stowell, Valeria Kallassy, Beth Lane, Jonathan Abbott, Kieran Borgeat, David Connolly, Oriol Domenech, Joanna Dukes-McEwan, Luca Ferasin, Josefa Fernández Del Palacio, Chris Linney, Jose Novo Matos, Ilaria Spalla, Nuala Summerfield, Tommaso Vezzosi, James P. Howard, Matthew J. Shun-Shin, Darrel P. Francis, Virginia Luis Fuentes
Artificial intelligence (AI) could improve accuracy and reproducibility of echocardiographic measurements in dogs.
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Effect of phenylbutazone on insulin secretion in horses with insulin dysregulation J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-16 Kate L. Kemp, Jazmine E. Skinner, François-René Bertin
Phenylbutazone is often prescribed to manage pain caused by hyperinsulinemia-associated laminitis, but in diabetic people nonsteroidal anti-inflammatory drugs increase insulin secretion and pancreatic activity.
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Prevalence and severity of exercise-induced pulmonary hemorrhage in 2-year-old Thoroughbred racehorses and its relationship to performance J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-16 Sierra Shoemaker, Yuan Wang, Debra Sellon, Jenifer Gold, Allison Fisher, Julia Bagshaw, Renaud Leguillette, Macarena Sanz, Warwick Bayly
Little has been reported regarding the prevalence and severity of exercise-induced pulmonary hemorrhage (EIPH) in 2-year-old Thoroughbred racehorses.
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Serial monitoring of pancreatic lipase immunoreactivity, C-reactive protein, abdominal ultrasonography, and clinical severity in dogs with suspected pancreatitis J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-16 Leslie Mitchell, Sichao Wang, Jody Lawver, Harry Cridge
Diagnosis of pancreatitis is based on clinical signs, pancreatic lipase immunoreactivity (cPLI), and abdominal ultrasonography (AUS). Diagnostic discrepancies exist between test results which might be related to differences in the timeline for resolution of these abnormalities after pancreatic injury.
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Diagnostic and predictive ability of hyperbilirubinemia severity in cats: A multicenter retrospective study J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-15 Xavier Salord Torres, Kamalan Jeevaratnam, Imogen Schofield, Samantha Taylor, Jennifer Stallwood, Menai Heyes, Daniel Hughes, Pieter Defauw
Total serum bilirubin concentration (TBIL) can provide useful information on several pathophysiological conditions in cats. Nevertheless, whether the variable severity classification of hyperbilirubinemia can reliably indicate certain disease processes or predict a biliary obstruction (BO) has not been investigated.
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Evaluation of risk factors for sleep-disordered breathing in dogs J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-15 Iida Niinikoski, Sari-Leena Himanen, Mirja Tenhunen, Mimma Aromaa, Liisa Lilja-Maula, Minna M. Rajamäki
Brachycephalic dogs display sleep-disordered breathing (SDB). The risk factors for SDB remain unknown.
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A retrospective study of hydrocortisone continuous rate infusion compared with administration of dexamethasone boluses in dogs with adrenal crisis J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-14 Lara Brunori, Olivia X. Walesby, Daniel H. Lewis, Alisdair M. Boag
Evidence indicating the optimal treatment protocol for dogs in adrenal crisis is lacking.
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Detection of nephrocalcinosis using ultrasonography, micro-computed tomography, and histopathology in cats J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-13 Pak-Kan Tang, Rebecca F. Geddes, Yu-Mei Chang, Rosanne E. Jepson, Dirk Hendrik Nicolaas van den Broek, Nicola Lötter, Jonathan Elliott
Identification of nephrocalcinosis in cats with chronic kidney disease (CKD) is of clinical interest but the ability of ultrasonography to detect nephrocalcinosis is uncertain.
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Candidate circulating microRNA biomarkers in dogs with chronic pancreatitis J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-13 Susan K. Armstrong, Robert W. Hunter, Wilna Oosthyuzen, Maciej Parys, Adam G. Gow, Silke Salavati Schmitz, James W. Dear, Richard J. Mellanby
Pancreatitis is an important cause of disease and death in dogs. Available circulating biomarkers are not sufficiently sensitive and specific for a definitive diagnosis.
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Clustering analysis of lipoprotein profiles to identify subtypes of hypertriglyceridemia in Miniature Schnauzers J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-13 Nicole M. Tate, Punyamanee Yamkate, Panagiotis G. Xenoulis, Jörg M. Steiner, Erica L. Behling-Kelly, Aaron K. Rendahl, Yu-An Wu, Eva Furrow
Hypertriglyceridemia (HTG) is prevalent in Miniature Schnauzers, predisposing them to life-threatening diseases. Varied responses to management strategies suggest the possibility of multiple subtypes.
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Correlation between urine anion gap and urine ammonia-creatinine ratio in healthy cats and cats with kidney disease J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-13 Alyssa R. Berman, Andrew J. Specht, Rebeca A. Castro, Kirsten L. Cooke, Shir Gilor, Autumn N. Harris
Ammonium excretion decreases as kidney function decreases in several species, including cats, and may have predictive or prognostic value in patients with chronic kidney disease (CKD). Urine ammonia measurement is not readily available in clinical practice, and urine anion gap (UAG) has been proposed as a surrogate test.
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Intraobserver and interobserver agreement of 8 segmental reflexes in healthy dogs J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-10 Bryan Chiang, Gabriel Garcia, Francesco Leverone, Jorge A. Hernandez, Sheila Carrera-Justiz
No available literature supports the claim that the patellar and withdrawal (flexor) reflexes are the only reliable segmental reflexes in dogs.
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Retrospective evaluation of 22 dogs with leptospirosis treated with extracorporeal renal replacement therapies (2018-2021) J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-09 Antonia Da Fonseca Ioannou, Carolyn Tai, Mary Anna Labato, Emmanuelle M. Butty
Outcomes of dogs with acute kidney injury secondary to leptospirosis (AKI-L) treated using renal replacement therapies (RRT) are poorly characterized.
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Effect of amlodipine on the circulating renin-angiotensin-aldosterone system in healthy cats J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-09 Tatiana M. Garcia Marrero, Jessica L. Ward, Melissa A. Tropf, Agnes Bourgois-Mochel, Emilie Guillot, Oliver Domenig, Lingnan Yuan, Debosmita Kundu, Jonathan P. Mochel
Systemic hypertension (SH) is a common cardiovascular disease in older cats that is treated primarily with the calcium channel blocker amlodipine besylate (AML). The systemic effect of AML on the classical and alterative arms of the renin-angiotensin-aldosterone system (RAAS) in cats is incompletely characterized.
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Sensorineural deafness in purebred white Devon Rex cats J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-08 Annemarie Kortas, Andrzej Pomianowski, Malgorzata Kolecka, Liliana Rytel
Data regarding congenital sensorineural deafness (CSD) in client-owned, white Devon Rex cats is limited because most of the information on this disease comes from experiments on mixed-breed cats.
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Serum concentrations of complement C3 and C4 in dogs with idiopathic epilepsy J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-08 Seonggweon Kang, Yoonhoi Koo, Taesik Yun, Yeon Chae, Dohee Lee, Hakhyun Kim, Mhan-Pyo Yang, Byeong-Teck Kang
High concentrations of complement factors are presented in serum of animal epilepsy models and human patients with epilepsy.
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Comparison of D-dimer concentration and thromboelastography for diagnosis of cerebrovascular accidents in dogs: A retrospective study J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-08 Elizabeth DiPaola, Starr Cameron, Helena Rylander, Natalia Zidan, Scott Hetzel
Cerebrovascular accidents (CVAs) in dogs are diagnosed using magnetic resonance imaging (MRI). This modality is sometimes unavailable, and CVAs can resemble other lesions on MRI. D-dimer concentration and thromboelastography (TEG) are utilized in human medicine in addition to diagnostic imaging to support diagnosis of CVAs, but their use in veterinary patients has not been assessed.
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Journal of Veterinary Internal Medicine manuscript reviewers who critiqued in the 2023 calendar year J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-08
The Editorial Board thanks the following individuals for their time and effort spent in reviewing and critiquing manuscripts during the 2023 calendar year
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Hypothalamic-pituitary-adrenal axis recovery after intermediate-acting glucocorticoid treatment in client-owned dogs J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-06 Francesca Del Baldo, Andrea Corsini, Antonio Maria Tardo, Alessandro Tirolo, Ada Sapignoli, Michele Tumbarello, Kateryna Vasylyeva, Federico Fracassi
In dogs, duration of hypothalamic-pituitary-adrenal (HPA) axis suppression after systemic glucocorticoid treatment is reported to vary from a few days to up to 7 weeks after glucocorticoid discontinuation. These data are derived mainly from experimental studies in healthy dogs and not from animals with spontaneous disease.
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Reason for euthanasia in dogs with urothelial carcinoma treated with chemotherapy or radiation therapy or both: A retrospective observational study J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-05 Charly McKenna, Valerie J. Poirier, Michelle L. Oblak, Stephanie Nykamp, Anthony J. Mutsaers
Clients want to know the ultimate cause of death in their pet after cancer treatment. The cause of euthanasia and investigation of urinary obstruction in treated dogs with urothelial carcinoma (UC) has not been specifically reported in veterinary literature.
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Assessment of the likelihood of hypothyroidism in dogs diagnosed with and treated for hypothyroidism at primary care practices: 102 cases (2016-2021) J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-05 Victoria Travail, Carolina Fernandez Sanchez, Jose M. Costo, Nicola Valentine, Megan Conroy, Venessa Lee, Dimitrios Bouziopoulos, Kathryn Bateman, Emma Gatehouse, Judith Cruzado-Perez, Danica Pollard, Valerie Lamb, Florence Juvet, Darren Kelly
There is a possibility that an incorrect diagnosis of hypothyroidism could be made in euthyroid dogs, and the prevalence of hypothyroidism in the dog population remains unknown.
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Evaluation of a urine dipstick protein to urine specific gravity ratio for the detection of proteinuria in dogs and cats J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-02 Michael Barchilon, Nichole Perez-Nieves, Jean-Sébastien Palerme
The utility of urine dipsticks for the quantification of proteinuria is limited because of the influence of urine specific gravity (USG). To circumvent the need for urine protein creatinine ratios (UPCR) some have proposed a calculated dipstick urine protein to USG ratio (DUR) for the detection of proteinuria. However, the performance of DUR has not been evaluated in veterinary patients.
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Comparison of timing of relapse in dogs with nonassociative immune-mediated hemolytic anemia, thrombocytopenia, or polyarthritis J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-02-02 Richard Sparrow, James W. Swann, Barbara Glanemann
Relapse is a clinical concern in dogs diagnosed with immune-mediated hemolytic anemia (IMHA), thrombocytopenia (ITP), or polyarthritis (IMPA). The average time to relapse is unknown, and evidence that vaccination is associated with disease relapse is lacking.
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Association of the neutrophil-lymphocyte ratio with outcome in sick hospitalized neonatal foals J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-29 Amanda N. Samuels, Ahmed M. Kamr, Stephen M. Reed, Nathan M. Slovis, Laura D. Hostnik, Teresa A. Burns, Ramiro E. Toribio
The neutrophil-lymphocyte ratio (NLR) in human medicine is an objective biomarker that reflects prognosis. The NLR as an independent biomarker to help predict nonsurvival in hospitalized neonatal foals has not been thoroughly interrogated.
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Spontaneous remission and relapse of diabetes mellitus in a male dog J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-19 Mariola B. Rak, Chen Gilor, Stijn J. M. Niessen, Eva Furrow
An 8-year-old male neutered Miniature Schnauzer was diagnosed with diabetes mellitus based on fasting hyperglycemia and glucosuria after a 2-week history of polydipsia and periuria, in line with the Agreeing Language in Veterinary Endocrinology consensus definition. Treatment of insulin and dietary management was initiated. The insulin dose was gradually reduced and eventually discontinued over the
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A retrospective study of the efficacy of zonisamide in controlling seizures in 57 cats J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-19 Dylan M. Djani, Michael Liou, Srikanth Aravamuthan, Vivian Lau, Starr Cameron
Evidence-based recommendations for antiepileptic drug selection in cats beyond phenobarbital are limited, and additional studies are needed for cats where seizures remain inadequately controlled by administration of phenobarbital alone or for cats that cannot safely receive phenobarbital.
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Serum symmetric dimethylarginine in older dogs: Reference interval and comparison of a gold standard method with the ELISA J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-19 Sofie Marynissen, Greet Junius, Evi Van den Steen, Lisbeth Patteet, Luc Duchateau, Siska Croubels, Sylvie Daminet, Dominique Paepe
Serum symmetric dimethylarginine (SDMA) is used to screen for renal dysfunction in dogs. The gold standard technique for measuring SDMA, liquid chromatography-tandem mass spectrometry (LC-MS/MS) is not widely available. Age-specific reference intervals for SDMA in older dogs are lacking.
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The efficacy of N-acetylcysteine in decreasing airway inflammation and mucus accumulation in horses with 18 hours of head confinement J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-18 Hamid Tavanaeimanesh, Zahra Alinia, Sirous Sadeghian Chaleshtori, Hamidreza Moosavian, Zeinab Mohebi, Mojtaba Daneshi
During transportation many horses develop post-transportation infection, which can be life-threatening and end their sport career. Preventing mucus accumulation and inflammation during transportation is vital, emphasizing the need for effective strategies to enhance overall horse health welfare.
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ACVIM consensus statement on diagnosis and management of urinary incontinence in dogs J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-13 Allison Kendall, Julie K. Byron, Jodi L. Westropp, Joan R. Coates, Shelly Vaden, Chris Adin, Garrett Oetelaar, Joe W. Bartges, Jonathan D. Foster, Larry G. Adams, Natasha Olby, Allyson Berent
Urinary incontinence (UI) is a disorder of micturition that can occur in dogs of any age, sex, and breed depending on the underlying cause and time of onset. Diagnosis and treatment for various causes of UI in dogs have been described by multiple comprehensive single author review articles, but large prospective clinical trials comparing treatment outcomes in veterinary medicine are lacking. The objectives
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Clinical and imaging findings in dogs with nerve root signature associated with cervical intervertebral disc herniation J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-12 Jordan Schachar, Alan Bocage, Nathan C. Nelson, Peter J. Early, Christopher L. Mariani, Natasha J. Olby, Karen R. Muñana
Intervertebral disc herniation (IVDH) is the most common spinal cord disease in dogs. Little information is available regarding the clinical presentation of nerve root signature (NRS) associated with cervical IVDH.
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Development of a requirement for exogenous insulin treatment in dogs with hyperglycemia J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-11 Angielee DiNinni, Rebecka S. Hess
It has been suggested that overt diabetes mellitus in dogs be defined based on a persistent fasting blood glucose concentration (BGC) >144 mg/dL.
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Measurement of 8-hydroxy-2′-deoxyguanosine in serum and cerebrospinal fluid of horses with neuroaxonal degeneration and other causes of proprioceptive ataxia J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-11 Megan Palmisano, Jeaneen Kulp, Susan Bender, Darko Stefanovski, Mary Robinson, Amy Johnson
Eight-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative damage evaluated in human neurodegenerative disease, has potential to correlate with postmortem diagnosis of neuroaxonal dystrophy/degenerative myeloencephalopathy (NAD/DM) in horses.
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Acute hypernatremia and hypocalcemia after oral sodium phosphate administration to a dog J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-11 Julia VanDerslice, Maureen Carroll
A 15-year-old male neutered mixed breed dog weighing 28 kg presented to a referral center after developing severe tremors and altered mentation. There was hypocalcemia and hypernatremia after oral administration of sodium phosphate as a bowel cleansing agent in preparation for colonoscopy. The dog was treated intravenously with low sodium fluids and calcium gluconate. Neurologic status and electrolyte
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Clinicopathological findings, treatment, and outcome in 60 cats with gastrointestinal eosinophilic sclerosing fibroplasia J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-11 Petra Černá, Cristobal Lopez-Jimenez, Kenjiro Fukushima, Ko Nakashima, Taisuke Nakagawa, Fiona Adam, Anna Groth, Andrew Denning, Nicolas Israeliantz, Danièlle A. Gunn-Moore
Gastrointestinal eosinophilic sclerosing fibroplasia (GESF) in cats presents as mass(es) associated with the gastrointestinal tract, mesentery, and abdominal lymph nodes.
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Medial strabismus (esotropia) at rest associated with contralateral paramedian thalamic ischemic infarction in 2 dogs J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-11 Theofanis Liatis, Ioannis N. Plessas, Holger Volk, Danielle Whittaker
Pseudoabducens paralysis resulting in resting medial strabismus (esotropia) is a rare consequence of a contralateral paramedian thalamic ischemic infarction in people. To date, esotropia has been reported in dogs in association with ipsilateral abducens neuropathy or extraocular myopathy, but not secondary to thalamic lesions. A 7-year-old male neutered Border Collie and a 12-year-old female neutered
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The effect of ε-aminocaproic acid on blood product requirement, outcome and thromboelastography parameters in severely thrombocytopenic dogs J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-11 Johanna Wolf, Laura K. Ruterbories, Ian Handel, Bernie Hansen
No treatment other than platelet administration is known to protect against spontaneous hemorrhage in thrombocytopenic dogs.
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A prospective cohort study to identify clinical diagnostic and prognostic markers of primary immune thrombocytopenia in dogs J. Vet. Intern. Med. (IF 2.6) Pub Date : 2024-01-11 Marjory B. Brooks, Robert Goggs, Amelia H. Frye, Jessica Armato, Marnin Forman, Julia Hertl, Michael Koch, John P. Loftus, John Lucy, Brandi Mattison, Julia Merriam, Sarah Shropshire, Laura Van Vertloo, Austin Viall, Dana N. LeVine
Primary immune thrombocytopenia (pITP) in dogs presents a diagnostic challenge, and clinical markers of severity are lacking.