-
The possible link between aluminum phosphide poisoning and NLRP3 inflammasome Med. Hypotheses (IF 4.7) Pub Date : 2024-04-17 Shirin Hekmatirad, Mohammad Abdollahi
Aluminum phosphide (AlP) is a fumigant used to control pests. However, human exposure to this substance can lead to poisoning. AlP reacts with gastric acid and water to release phosphine (PH3). This toxic gas affects the mitochondria and quickly enters the bloodstream. This gas impairs the mitochondria's ability to generate ATP, leading to oxidative stress, mitochondrial dysfunction, and damage to
-
Acidic solution irrigation as a novel approach for treating infected walled-off pancreatic necrosis Med. Hypotheses (IF 4.7) Pub Date : 2024-04-12 Yongliang Tang, Zhengyan Li, Menggang Liu, Hongming Liu, Juntao Yang
Walled-off pancreatic necrosis (WOPN) is a severe complication of acute pancreatitis arising from pancreatic or peripancreatic necrosis complicated by infection, leading to elevated mortality rates. Extravasation of pancreatic juice creates a weakly alkaline microenvironment favorable for the survivial of translocated intestinal bacteria and activated pancreatic enzyme-mediated autodigestion of pancreatic
-
An integrated thermal sensation scale for estimating thermal strain in water Med. Hypotheses (IF 4.7) Pub Date : 2024-04-11 Maria Ntoumani, Helen Soultanakis, Eric Rivas, Benoit Dugué, Adam W. Potter, Irena Yermakova, Angeliki Douka, Konstantina Gongaki
-
Microcirculatory disturbance: A new mechanism of brain swelling after traumatic brain injury? Med. Hypotheses (IF 4.7) Pub Date : 2024-04-11 Liang Xian, Long Lin, Sang Chen, Li Chen, Shuwen Mu, Shousen Wang
The mechanism of traumatic brain swelling has not been fully studied, and various existing theories lack strong experimental evidence. Through comprehensive analysis of current theories, it was found that microcirculation disturbance may be an important mechanism in the early stage of traumatic brain swelling. Therefore, we hypothesized that in patients with severe brain injury, partial cerebral venous
-
Dual acid-pump blocking as novel therapeutic approach to treatment of acid-related diseases Med. Hypotheses (IF 4.7) Pub Date : 2024-04-10 György Miklós Buzás
Proton-pump inhibitors are highly efficient in the treatment of acid-related disease; however, their efficacy in treating reflux symptoms, healing esophageal erosions and peptic ulcers and eradicating is sometimes suboptimal. Potassium-competitive acid blockers have a different mechanism of action, resulting in higher and longer-lasting increases in intragastric pH, which is neither non-inferior or
-
A reply to “Comment on: Hypothesis testing of the adoption of pseudoscientific methods” Med. Hypotheses (IF 4.7) Pub Date : 2024-04-09 Dean McKay, Angela Coreil
-
The protein nutritional status affects hope of patients in the terminal phase of cancer Med. Hypotheses (IF 4.7) Pub Date : 2024-04-06 Wojciech Kolanowski, Bożena Baczewska, Krzysztof Leśniewski
Progressive destruction of the patient’s body in the terminal phase of cancer intensifies the breakdown of muscle tissue proteins, producing neurotoxic ammonia and urea. These metabolites negatively affect the brain function and are more difficult to remove from the cancer-ravaged body than from better-nourished patients. Developing cachexia impairs the functioning of all body organs, including the
-
The fundamental role of sleep is the reduction of thermodynamic entropy of the central nervous system Med. Hypotheses (IF 4.7) Pub Date : 2024-04-04 Rodolfo Soca, Tomas Gedeon, Hrayr Attarian
Sleep remains the last major biological process for which a fundamental role is still unknown. Engagement and responsiveness to the environment are the main functions that are present during wakefulness and decreased during sleep and they generate a very important and unavoidable thing: entropy. It is our hypothesis that sleep is the process by which animals deal with the continuous increase in entropy
-
Morphine acts via TLR4 resulting in neuroinflammation and immunosuppression Med. Hypotheses (IF 4.7) Pub Date : 2024-03-29 Jonaid Ahmad Malik, Javed N. Agrewala
Millions of people suffer globally from disorders caused by narcotic substances. Drug addiction leads to the destruction of an individual's life and risk to public safety. Morphine is the prime alkaloid well-known as the mother opiate and has many implications for the human body, specifically for the immune system. It down-regulates all the arms of the immune system and reduces its efficiency in combating
-
The reverse zoonosis transfer cycle from the human-animal-plant-environment interface: How antibiotic-resistant bacteria from humans threaten the environment and fuel the rise of superbugs Med. Hypotheses (IF 4.7) Pub Date : 2024-03-26 Bhagwan Narayan Rekadwad
The uncontrolled use of antibiotics for the treatment of human diseases and animal farming led to a global crisis in the form of the re-emergence of antibiotic-resistant bacteria (ARB). This paper critically explores the reverse zoonosis transfer cycle and highlights facts about ARB in the environment and re-infections in humans. ARB shed by humans through various routes contaminates the environment
-
Personalized repetitive transcranial magnetic stimulation guided by the spectral electroencephalogram may enhance and democratize therapy for autism spectrum disorder Med. Hypotheses (IF 4.7) Pub Date : 2024-03-21 Milan T. Makale, Kenneth Blum, Abdalla Bowirrat, Keerthy Sunder, Miles R. Makale, Mark S. Gold, Igor Elman, Catherine A. Dennen, Kevin T. Murphy
Autism spectrum disorder (ASD) is a genetically heterogeneous group of neurodevelopmental disorders that affect 1 in 36 children (CDC data) and have recognizable core deficits in common, including repetitive stereotyped behaviors and difficulties in social interaction and communication. Pharmacological interventions moderate some ASD comorbidities, but do not alleviate core deficits and have significant
-
Unmetabolized folic acid and organ fibrosis: Are they nefarious partners? Med. Hypotheses (IF 4.7) Pub Date : 2024-03-15 Mark R. Goldstein, Luca Mascitelli
Recent publications raise the possibility that folic acid (FA), specifically unmetabolized folic acid (UMFA), might promote the progression of organ fibrosis via signaling through folate receptors, leading to excessive extracellular matrix production by myofibroblasts and other cell types. Clinical research over the past two decades adds credence to this largely unexplored contention. FA is a synthetic
-
Elevated circulating procathepsin L as a potential biomarker of inflamm-aging Med. Hypotheses (IF 4.7) Pub Date : 2024-03-14 Cassie Shu Zhu, Weiqiang Chen, Xiaoling Qiang, Li Lou, Jianhua Li, Haichao Wang
Inflamm-aging is a condition of low-grade and chronic systemic inflammation characterized by a systemic increase in multiple inflammatory biomarkers such as tumor necrosis factor (TNF), interleukin 6 (IL-6), C-reactive protein (CRP), and CXCL9 (MIG) in experimental and clinical settings. However, despite the recent identification of extracellular procathepsin L (pCTS-L) as a novel mediator of inflammatory
-
Vibroacoustic therapy to treat pain in the temporomandibular joint Med. Hypotheses (IF 4.7) Pub Date : 2024-03-12 Panagiota Kitsantas, Maria C. Mejia, Robert Sewak, Lea Sacca, Charles H. Hennekens
Pain in the temporomandibular joint (TMJ) affects about 4.8 % of the United States population. Pain is the most common symptom of TMJ and the chief reason patients seek care. Conventional treatments range from non-invasive therapies including physical therapy, dental guards and occlusal splints to interventions such as corticosteroid injections and surgery. At present, the most common challenge to
-
Bouldering & chronic traumatic encephalopathy – That is repeated mild traumatic brain injury from climbing Med. Hypotheses (IF 4.7) Pub Date : 2024-03-11 Grzegorz Zieliński, Beata Pająk-Zielińska
Mild traumatic brain injury (mTBI) is one of the most common neurological conditions resulting from linear accelerations in the range of 60 gravity. Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative syndrome. Its etiopathology is attributed to repeated blows to the head and the transmission of acceleration and deceleration forces to the brain. There are several types of climbing
-
Breaking the 'undruggable' barrier: Revealing molecular mechanisms in Aurora Kinase A/Myc protein interplay targeting cancers Med. Hypotheses (IF 4.7) Pub Date : 2024-03-07 Ananaya Jain, Kiran Bharat Lokhande, Ashutosh Singh
The intricate interplay between Aurora Kinase A (AURKA) and the elusive oncogene N-myc plays a pivotal role in the progression of numerous cancers. Disrupting N-myc destabilization through targeted inhibition of Aurora Kinase A's ATP binding site has emerged as a promising strategy to impede cancer progression. Notably, inhibitors like Fostamatinib and Alisertib have demonstrated the complete disruption
-
Periodontitis could affect functional connectivity in the brain leading to worsening of neuro psychiatric disorders – A hypothesis Med. Hypotheses (IF 4.7) Pub Date : 2024-03-07 Aravind Kumar Subramanian, Saranya Varadarajan
It is a well-known fact that periodontitis is the result of destruction of the tooth supporting structures caused primarily by oral dysbiosis of dental plaque biofilm ultimately leading to tooth loss. The condition is very common and several studies have ascertained the association of periodontitis with systemic conditions such as diabetes mellitus, hypertension, adverse pregnancy outcomes, Alzheimer’s
-
Potential therapeutic targets for hypotension in duchenne muscular dystrophy Med. Hypotheses (IF 4.7) Pub Date : 2024-03-07 Harshi Saxena, Neal L. Weintraub, Yaoliang Tang
-
Amniotic extracelluar matrix microgels for attenuation of radiation-induced lung injury Med. Hypotheses (IF 4.7) Pub Date : 2024-03-06 Benxu Tan, Yan He
Radiation-induced lung injury (RILI) is one of the major complications in patients exposed to accidental radiation and radiotherapy for thoracic malignancies. However, there is no reliable approach to effectively treat RILI. With favorable biological and physical characteristics, decellularized extracellular matrix (dECM) from amniotic membrane can not only act as a reactive oxygen species scavenger
-
A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds Med. Hypotheses (IF 4.7) Pub Date : 2024-02-29 Zoha F. Murtaza, Ali Abou Fares, Fatima AlMuhairi, Jovana Paunovic, Svetlana Valjarevic, Igor V. Pantic, Peter R. Corridon
Corneal diseases and injuries, with their substantial global prevalence and adverse effects on quality of life, demographics, occupations, and lifestyles, pose a pressing healthcare challenge worldwide. Limited treatment options are unable to halt the progression of end-stage conditions, where transplantation is the ideal solution. Unfortunately, the high demand and low supply of corneal tissues, donor-recipient
-
Is Epstein Barr virus latency protective against type 1 diabetes? Med. Hypotheses (IF 4.7) Pub Date : 2024-02-28 Magdalena Zoledziewska
-
Unveiling novel therapeutic avenues: Targeting the cyclin D/CDK4 axis for enhanced cancer treatment Med. Hypotheses (IF 4.7) Pub Date : 2024-02-28 Kiran Bharat Lokhande, Ashish Shrivastava, Ashutosh Singh
The deregulation of the cyclin D/CDK complex is a prevalent feature in various cancer types, including colorectal cancer, breast cancer, and melanoma, leading to uncontrolled cell cycle progression and tumor growth. Targeting the cyclin D/CDK complex has emerged as a promising therapeutic strategy for cancer treatment. CDK4 inhibitors, such as ribociclib, palbociclib, and abemaciclib, have demonstrated
-
Potential therapeutic agent for the treatment of retinal detachment: Artificial interphotoreceptor matrix Med. Hypotheses (IF 4.7) Pub Date : 2024-02-25 Jiazhen Jiang, Dali Tong, Ziyang Ye, Can Deng, Lisong Wang, Kai Dong
Retinal detachment (RD) is a common ophthalmic emergency that presents as a separation and gap between the retinal neuroepithelium and the pigment epithelium that supplies the retina. Treatment for RD is primarily focused on surgically reattaching the retina as soon as possible. Nevertheless, the recovery of visual function in patients undergoing surgical retina reattachment of the retina is insufficient
-
Does repetitive transcranial magnetic stimulation induce long-lasting neuroplastic changes to improve detrusor muscle function in stroke survivors with neurogenic overactive bladder? Med. Hypotheses (IF 4.7) Pub Date : 2024-02-20 Mohammed Usman Ali, Georg S. Kranz, Kenneth N.K. Fong, Priya Kannan
Neurogenic overactive bladder (OAB) is purported to result from damage to the central inhibitory pathways in the brain and spinal cord or peripheral afferent terminal sensitization in the bladder, which unmasks the primitive voiding reflex. Excitation of the pontine micturition center activates descending neural pathways to the spinal cord, resulting in sequential detrusor contraction and urethral
-
COVID-19 infection activates genetically predisposed risk pathways in lungs to escalate T1D development Med. Hypotheses (IF 4.7) Pub Date : 2024-02-18 Daniel Ho, Justin M. O'Sullivan
After the COVID-19 pandemic started in 2019, it quickly spread and infected millions of people causing substantial economic and social disruptions worldwide. Type 1 Diabetes (T1D) incident rates were reported to increase in many countries unexpectedly. Accumulated evidence supported the elevated rates were promoted by the pandemic and the underlying mechanisms remained elusive. We propose the hypothesis
-
Targeting Stearoyl-CoA Desaturase: A novel approach for diabetes therapy Med. Hypotheses (IF 4.7) Pub Date : 2024-02-18 Pranav Kumar Prabhakar
Diabetes mellitus is an epidemic with serious health and financial consequences. While glycemic control is the primary focus of current diabetic care, new evidence points to the crucial role that lipid metabolism plays in the emergence of insulin resistance, particularly in type 2 diabetes. The enzyme stearoyl-CoA desaturase (SCD), which transforms saturated fatty acids into monounsaturated fatty acids
-
A “Periodic Table” approach to understand the pathophysiology of heart failure with preserved ejection fraction Med. Hypotheses (IF 4.7) Pub Date : 2024-02-17 Tolga Sinan Güvenç, Rengin Çetin Güvenç, Gizem Demir, Mohammad Tahir Nikzad, Ahmet Ekmekçi
Heart failure with preserved ejection fraction is a complex syndrome that is characterized by symptoms and signs of heart failure without an apparent reduction in left ventricular ejection fraction. Although the main pathophysiologic pathways related to HFpEF are grossly understood, whether all or a specific number of mechanisms are related to the genesis of HFpEF for a given patient remains elusive
-
Inquiring into the collusion between two-system diseases: Potential impact of hypertension over gastroesophageal reflux disease Med. Hypotheses (IF 4.7) Pub Date : 2024-02-17 Arícia G. Miranda, Andressa H.L. Rufino, Lorena P. Araruna, Katriane C. Silva, Isaac A.B. Gomes, Ramodnil M. Santos, Fernando S. Tallo, Francisco S. Menezes-Rodrigues, Leonardo P. Souza, Francisca B.M. Sousa, Jand V.R. Medeiros, Marcellus H.L.P. Souza, Lucas A.D. Nicolau
-
Protective effect of methylene blue in iron-induced neurotoxicity Med. Hypotheses (IF 4.7) Pub Date : 2024-02-17 Giulio Scigliano, Giuseppe Augusto Scigliano, Gabriele Ronchetti
Iron deposits have been identified as an intriguing pathological finding in the brain. Although generally considered benign, and, to a certain degree, necessary for various biochemical processes and functions, recent research suggests that abnormal iron deposits may exert harmful effects on brain tissue. Excessive iron accumulation in the brain, due to an imbalance in iron homeostasis and exacerbated
-
Gap junction modulators: Prospects in bupropion cardiotoxicity Med. Hypotheses (IF 4.7) Pub Date : 2024-02-16 Lorenzo Losso, Massimo Carollo, Giorgio Ricci
Bupropion, a multifaceted antidepressant, is associated with serious cardiotoxicity when misused. Recently, there has been a noticeable increase in cases of intentional poisoning and current therapeutic interventions for bupropion overdose remain insufficient. The cardiotoxic effects of the drug are primarily linked to its influence on cardiac gap junctions. Small-molecule drugs enhancing gap junction
-
May chin be considered a distinctive anatomical feature of a human skull? Med. Hypotheses (IF 4.7) Pub Date : 2024-02-16 Vladimir N. Nikolenko, Yury O. Zharikov, Marina G. Zhdanovskaya, Nikolay A. Zharov, Tatiana S. Zharikova, André Pontes-Silva, Nataliya V. Zharova
Why did the chin evolve and what are its functions? Many hypotheses about the functional significance of this formation have been put forward, but it has not been possible to prove all of them empirically, either due to the lack of data or the lack of the necessary equipment. The article discusses hypotheses about the appearance and significance of this formation, as well as future research directions
-
Summiting Mount Everest in deuterium depleting nutritional ketosis without supplemental oxygen Med. Hypotheses (IF 4.7) Pub Date : 2024-02-15 László G. Boros, Stephanie Seneff, James C. Lech, Marianna Túri, Zoltán Répás
During climbing seasons in the Himalaya only a few sportsmen attempt an ascent to and descent from the 8848 m top of the Earth without supplemental oxygen. This short report describes such successful summiting of the Mount Everest that rested with the nutritional, metabolic and exercise ketosis state, i.e., the burning of long chain saturated fat as the source of cellular energy after six failed attempts
-
New approach to acquired drug resistance and toxicity in cancer chemotherapy Med. Hypotheses (IF 4.7) Pub Date : 2024-02-12 Gerald M. Kolodny
Acquired drug resistance is a major cause of failure of cancer chemotherapy. Rapidly dividing cancer cells quickly evolve DNA mutations to bypass any single drug targeted metabolic pathway. Several drugs targeting different cancer biomarkers, can be used in combination, to target multiple biomarkers simultaneously, to reduce the tumor’s ability to provide sufficient mutations to evade the simultaneous
-
Comment on: Hypothesis testing of the adoption of pseudoscientific methods Med. Hypotheses (IF 4.7) Pub Date : 2024-02-12 Jeanne Talbot, Marjorie Robb, Jane Evans
-
Beyond the horizon: Exploring adverse childhood experiences and their lifelong, intergenerational influence on dental caries Med. Hypotheses (IF 4.7) Pub Date : 2024-02-12 Letícia R.M. Sartori, Sarah R. Baker, Marcos B. Corrêa
The influence of sociodemographic, psychological, and behavioral characteristics on dental caries development, maintenance, and treatment is well-established. Although current evidence shows a direct effect of Adverse Childhood Experiences (ACEs) on oral health-related outcomes, such as dental anxiety and tooth loss, the major impact in dental caries probably occurs through indirect pathways. Even
-
PCSK9 single nucleotide variants might affect susceptibility to malaria through regulation of CD36 Med. Hypotheses (IF 4.7) Pub Date : 2024-02-12 Frank S. Fan
Genetic polymorphism of proprotein convertase subtilisin/kexin type 9 (PCSK9), identified as single nucleotide variant (SNV), when locating at the Cys-His rich domain (CHRD), for example, E670G and I474V, is herein hypothesized to affect the domain’s binding affinity to cluster of differentiation 36 (CD36), which plays a major role in the phagocytosis of parasitized erythrocytes, and thus bringing
-
A novel etiological approach for the development of knee osteoarthritis in sedentary adults Med. Hypotheses (IF 4.7) Pub Date : 2024-02-11 Eloy del Río
Knee osteoarthritis, a common degenerative disease that causes a huge socioeconomic burden, is characterized by gradual deterioration of the articular cartilage, often leading to pain, stiffness, and impaired joint function. Addressing a significant public health concern, this study suggests that the combined effect of characteristic knee cartilage thickness—presumably a consequence of bipedal evolution—and
-
Can food affect the perception of time? Med. Hypotheses (IF 4.7) Pub Date : 2024-02-08 Vladimir Ajdžanović, Marko Miler, Branka Šošić-Jurjević, Branko Filipović
Time perception is an important and to some extent adjustable aspect of the human cognitive sphere. We hypothesize that the specific food consumption can affect the perception of time in two ways, namely through the emotions it triggers and through the nutrients it contains, which may affect brain chemistry. The “internal clock”, responsible for timing tasks, can be charged (accelerated) by arousal
-
Comment on: Can first cervical vertebrae misalignment be one of the possible etiology of globus pharyngeus? Med. Hypotheses (IF 4.7) Pub Date : 2024-02-08 Jiří Šedý
-
Pathogenesis of oral lichen planus according to Western versus Chinese traditional medicine: Is the truth somewhere in-between? Med. Hypotheses (IF 4.7) Pub Date : 2024-02-07 Ayat Gamal-AbdelNaser, Noha Adel Azab
Oral lichen planus (OLP) is considered a jeopardizing common chronic potentially malignant disease. Its etiology is yet undiscovered and pathogenesis has tangled elements; therefore, it receives symptomatic management rather than eradicative treatment. This is reflected in lower levels of quality of life and poorer prognosis. The disease is described by Western medicine techniques to be stimulated
-
Stool bacterial dysbiosis, Crystalluria and Oxaluria: A SbCO Index value may define risk for recurrence of oxalate nephrolithiasis episode Med. Hypotheses (IF 4.7) Pub Date : 2024-02-06 Mangesh V. Suryavanshi, Yogesh S. Shouche, Aaron W. Miller
Kidney stone disease, particularly those formed from calcium oxalate crystals, is a significant health challenge, especially in geographic regions with high recurrence rates, known as stone belt regions. Early and precise prediction of stone events is crucial for effective therapeutic intervention. We propose the ‘Stool bacterial dysbiosis, Crystalluria, and Oxaluria (SbCO) Value Index,’ a composite
-
The possible role of altered oropharyngeal microbiota in differentiating true psychosis from malingered psychosis in a forensic psychiatric setting Med. Hypotheses (IF 4.7) Pub Date : 2024-02-05 Mohsen Khosravi, Mohammed Yousif Merza, Raed Obaid Saleh, Hina Ayaz Habib, Ahmad K. Alnemare, Turki Bin Mahfoz, Usama Bin Ghaffar, Pallavi Ghildiyal, Sarah Jawad Shoja, Ahmed Elawady
Over the past few years, malingered psychosis has had a progressive occurrence since a great deal of attention has been directed to the closures of long-stay psychiatric institutions and care in the community. Therefore, malingered psychosis needs to be identified to conduct precise forensic assessments and prevent miscarriages of justice and misuse of restricted healthcare resources. Although, over
-
A novel therapeutic strategy for acute decompensated heart failure with vasodilators Med. Hypotheses (IF 4.7) Pub Date : 2024-02-05 Yu Pan, Juan Yang, Zhu Qing Feng, Yan Yuan, Xue Yin Tang, Jiang Chuan Dong
Acute decompensated heart failure (ADHF) is a condition of substantial public health significance, marked by elevated morbidity and mortality rates. Despite advancements in the management of chronic heart failure, effective interventions for ADHF remain elusive. The cardinal manifestations of ADHF primarily stem from congestion, underscoring the pivotal role of vasodilators in a comprehensive therapeutic
-
Hypothesis: Androgen receptor/Aurora A kinase/NF-κB signaling axis induce inflammatory response during polycystic ovarian syndrome progression Med. Hypotheses (IF 4.7) Pub Date : 2024-02-05 Manoj Kumar
Polycystic ovarian syndrome (PCOS) is one of the most frequent endocrinopathies, affecting women of reproductive age, and characterized by the presence of cysts, anovulation, hyperandrogenism, insulin resistance, and persistent inflammation. The prevalence rate of PCOS in India is comparatively high compared to other parts of the world, and it varies from 8 to 22% in reproductive age of women, whereas
-
Comment on “Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice” Med. Hypotheses (IF 4.7) Pub Date : 2024-02-04 Zheng Shen, Qiangang Wang
Abstract not available
-
The potential association between salivary gland hypofunction and systemic homeostasis Med. Hypotheses (IF 4.7) Pub Date : 2024-01-28 Wenpeng Song, Jian Zhou, Xiaoyan Wang, Hao Wang
Medications, head and neck cancer radiotherapy, aging, and numerous systemic diseases are considered causes of salivary gland hypofunction. However, whether salivary gland dysfunction is the risk factor for systemic diseases and whether it affects the overall systemic homeostasis have not been clearly elucidated. In this study, we hypothesize that salivary gland hypofunction may be associated with
-
Rubber-banding and the phenomenon of global hypoperfusion Med. Hypotheses (IF 4.7) Pub Date : 2024-02-02 Thomas Avritt, Habib Srour
Patients with distributive shock and global hypoperfusion are encountered frequently in both the operating room and the intensive care unit, and they pose ongoing challenges to providers. This article discusses what we have termed “rubber-banding,” a pattern of hemodynamic instability that we have noticed in such patients, initiated by the reperfusion of ischemic tissue and washout of “evil humors”
-
Can atrial lead system ameliorate the diagnosis of atrial arrhythmias? Med. Hypotheses (IF 4.7) Pub Date : 2024-02-01 N. Prasanna Venkatesh, R. Pradeep Kumar, Bala Chakravarthy Neelapu, Kunal Pal, J. Sivaraman
The diagnosis of atrial arrhythmia is problematic due to low signal voltage and susceptibility to noise and artifacts. Electrocardiogram (ECG) is a commonly used, cost-effective tool for diagnosing cardiac arrhythmias. However, detecting certain waves, such as P and -waves, in a standard 12-lead ECG is still challenging and frequently cause false positive diagnoses of atrial arrhythmias. Therefore
-
Delivery of PTEN protein into tumor cells as a promising strategy for cancer therapy via active albumin nanoparticles: A hypothesis Med. Hypotheses (IF 4.7) Pub Date : 2024-01-24 Run Meng, Ling Zuo, Xiaorong Zhou
The phosphate and tensin homology (PTEN) protein, often mutated or absent in tumor cells, compromises its role as a tumor suppressor. Addressing this deficit in PTEN functionality within tumor cells holds immense promise for effective anti-tumor strategies. Notably, the high expression of glycoprotein 60 (Gp60, also named as albondin) in vascular endothelial cells, serving as a prevalent albumin receptor
-
-
Revolution of artificial intelligence in antimicrobial, anti-biofilm, and anti-inflammatory techniques: Smart photo-sonodynamic appliance in the internet of dental things (IoDT) Med. Hypotheses (IF 4.7) Pub Date : 2024-01-24 Maryam Pourhajibagher, Rashin Bahrami, Abbas Bahador
Antimicrobial photo-sonodynamic therapy (aPSDT) is a promising treatment for microbial infections, but it faces challenges such as bacterial resistance, limited anti-inflammatory effects, and a doctor-centered approach. We hypothesize that the integration of artificial intelligence (AI), Internet of Dental Things (IoDT), and aPSDT to enhance the efficiency and effectiveness of aPSDT by focusing on
-
Human aging and perception of time in view of the Earth’s motion events Med. Hypotheses (IF 4.7) Pub Date : 2024-01-18 Bogdan I. Gerashchenko
Here we consider human aging and time perception by operating with time, as a physical quantity, linked to periodic motions of the Earth. Taking into account the periodicity of Earth’s revolutions, the model of aging in a form like Fermat’s spiral has been proposed. This model demonstrates the progressive extension of the paces of aging implying accelerated accumulation of adverse changes over life
-
A promising method for reducing the incidence of diabetic foot ulcers: Regulating foot temperature during walking Med. Hypotheses (IF 4.7) Pub Date : 2024-01-14 Yijie Duan, Kexin Zhang, Yan Xu, Weiyan Ren, Fang Pu
Diabetic foot ulcers (DFUs) pose a significant challenge in the medical field, particularly with the rising prevalence of diabetes. Consequently, there’s a growing emphasis on devising effective prevention strategies to combat the high recurrence rate of these ulcers. Daily walking, while essential for maintaining a normal lifestyle and social interaction is also the primary source of external mechanical
-
Neuron-targeted exosome therapy: A novel approach for treating cardiogenic dementia via RyR2 inhibition Med. Hypotheses (IF 4.7) Pub Date : 2024-01-09 Richa Saxena, Yaoliang Tang
-
Distinctive feeding vessel architecture and sparse collateralization may underlie the characteristic early temporal pole and external capsule white matter compromise in CADASIL Med. Hypotheses (IF 4.7) Pub Date : 2024-01-11 Marina Blanco-Ruiz, Jeffrey L. Saver
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cause of stroke. Mutations in the NOTCH3 gene cause vasculopathic changes predominantly involving medium and small brain arteries leading to progressively impaired cerebrovascular autoregulation, hypoperfusion, and ischemia. Magnetic resonance neuroimaging of CADASIL patients
-
Can first cervical vertebrae misalignment be one of the possible etiology of globus pharyngeus? Med. Hypotheses (IF 4.7) Pub Date : 2024-01-02 Ömer Faruk Yaşaroğlu, Selen Serel Arslan, Numan Demir
Globus pharyngeus (GP) is a problem characterised by the sensation of a foreign body in the throat. Although it was previously considered as a psychological problem, it has been associated with various etiological factors such as gastrointestinal problems and cervical pathologies. The etiology and treatment of globus pharyngeus is still controversial in the literature. The hyoid muscles are innervated
-
Do early indicators of euthyroid sick syndrome predict later post-bariatric weight loss? Exploring a novel hypothesis Med. Hypotheses (IF 4.7) Pub Date : 2024-01-03 Debra L. Safer, Natasha Fowler, Sarah Adler, Carol N. Rowsemitt, Thomas Najarian
Despite bariatric surgery’s success for most patients, up to 30 % do not experience optimal weight loss outcomes. Post-surgery weight loss outcomes are influenced by a complex interplay of factors that remain incompletely understood. Novel hypotheses are needed to identify putative predictors of suboptimal post-bariatric weight loss. Thyroid hormones, due to their important role in energy expenditure
-
Moving beyond Vesalius: Why anatomy needs a mapping update Med. Hypotheses (IF 4.7) Pub Date : 2024-01-02 Graham Scarr, Leonid Blyum, Stephen M Levin, Susan Lowell de Solórzano
The improvement of the human condition is the driver behind a vast amount of ongoing research and naturally employs the most up-to-date methods in its endeavours. It has contributed greatly to our understanding of the body and benefitted our healthcare systems in remarkable ways, but there is a problem. The mapping of anatomy to its physiological functions is essentially derived from the work of Vesalius
-
-
Piezo1 mediates abnormal type 2 immune response to aggravate ischemia–reperfusion acute lung injury which by regulating alveolar macrophages derived IL-33: A hypothesis Med. Hypotheses (IF 4.7) Pub Date : 2023-12-25 Liu XiWang, Wang XueKe, Pan YiHang, Ying LiYang, Xu WeiZe, Lai DengMing, Chen WeiWei, Jin Yue, Fan XiangMing, Wang WenYang, Shu Qiang
The pathogenesis of ischemia–reperfusion acute lung injury (IR-ALI) is not yet fully understood. We previously reported that unwonted increased type 2 immunity plays a key role in the pathogenesis and the pathophysiological process in acute haemorrhagic induced lung injury. Progressive lung edema after ischemia reperfusion is accompanied by the change of lung cyclical hydrostatic force. The changed