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3D skin bioprinting as promising therapeutic strategy for radiation‐associated skin injuries Wound Repair Regen. (IF 2.9) Pub Date : 2024-04-11 Xiaofan Lv, Na Zhao, Shuang Long, Guojian Wang, Xinze Ran, Jining Gao, Junping Wang, Tao Wang
Both cutaneous radiation injury and radiation combined injury (RCI) could have serious skin traumas, which are collectively referred to as radiation‐associated skin injuries in this paper. These two types of skin injuries require special managements of wounds, and the therapeutic effects still need to be further improved. Cutaneous radiation injuries are common in both radiotherapy patients and victims
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In the face and neck, keloid scar distribution is related to skin thickness and stiffness changes associated with movement Wound Repair Regen. (IF 2.9) Pub Date : 2024-04-11 Hoyu Cho, Teruyuki Dohi, Hanae Wakai, Whitney Laurel Quong, Nguyen Doan Tien Linh, Satoshi Usami, Rei Ogawa
Keloid scars tend to occur in high‐tension sites due to mechanical stimuli that are involved in their development. To date, a detailed analysis of keloid distribution focused specifically on facial and neck areas has not been reported, and limited literature exists as to the related mechanical factors. To rectify this deficiency of knowledge, we first quantified the facial and neck keloid distribution
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Low‐temperature plasma jet suppresses bacterial colonisation and affects wound healing through reactive species Wound Repair Regen. (IF 2.9) Pub Date : 2024-04-11 Yang Ge, Jun Wang, DongHua Gu, Wei Cao, Yongtong Feng, Yanfan Wu, Han Liu, Zhengping Xu, Zhe Zhang, Jinsong Xie, Shuang Geng, Junrui Cong, Yi Liu
An argon‐based low‐temperature plasma jet (LTPJ) was used to treat chronically infected wounds in Staphylococcus aureus‐laden mice. Based on physicochemical property analysis and in vitro antibacterial experiments, the effects of plasma parameters on the reactive nitrogen and oxygen species (RNOS) content and antibacterial capacity were determined, and the optimal treatment parameters were determined
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Porcine‐derived collagen peptides promote re‐epithelialisation through activation of integrin signalling Wound Repair Regen. (IF 2.9) Pub Date : 2024-04-04 Krishan Mistry, Grant Richardson, Sara Vleminckx, Robert Smith, Elien Gevaert, Penny E. Lovat
Chronic non‐healing cutaneous wounds represent a major burden to patients and healthcare providers worldwide, emphasising the continued unmet need for credible and efficacious therapeutic approaches for wound healing. We have recently shown the potential for collagen peptides to promote proliferation and migration during cutaneous wound healing. In the present study, we demonstrate that the application
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Update of biomarkers to diagnose diabetic foot osteomyelitis: A meta‐analysis and systematic review Wound Repair Regen. (IF 2.9) Pub Date : 2024-04-03 Elizabeth A. Ansert, Arthur N. Tarricone, Tyler L. Coye, Peter A. Crisologo, David Truong, Mehmet A. Suludere, Lawrence A. Lavery
The aim of this study was to evaluate the diagnostic characteristics of biomarker for diabetic foot osteomyelitis (DFO). We searched PubMed, Scopus, Embase and Medline for studies who report serological markers and DFO before December 2022. Studies must include at least one of the following diagnostic parameters for biomarkers: area under the curve, sensitivities, specificities, positive predictive
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What is slough? Defining the proteomic and microbial composition of slough and its implications for wound healing Wound Repair Regen. (IF 2.9) Pub Date : 2024-04-01 Elizabeth C. Townsend, J. Z. Alex Cheong, Michael Radzietza, Blaine Fritz, Matthew Malone, Thomas Bjarnsholt, Karen Ousey, Terry Swanson, Gregory Schultz, Angela L. F. Gibson, Lindsay R. Kalan
Slough is a well‐known feature of non‐healing wounds. This pilot study aims to determine the proteomic and microbiologic components of slough as well as interrogate the associations between wound slough components and wound healing. Ten subjects with slow‐to‐heal wounds and visible slough were enrolled. Aetiologies included venous stasis ulcers, post‐surgical site infections and pressure ulcers. Patient
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Donepezil promotes skin flap survival through activation of the HIF‐1α/VEGF signalling pathway Wound Repair Regen. (IF 2.9) Pub Date : 2024-03-29 Hang Lin, Kaitao Wang, Jialong Yang, An Wang, Jiapeng Deng, Dingsheng Lin
Flaps are mainly used to repair wounds in the clinical setting but can sometimes experience ischaemic necrosis postoperatively. This study investigated whether donepezil, an acetylcholinesterase inhibitor, can enhance the survival rate of flaps. We randomly allocated 36 rats into control, low‐dose (3 mg/kg/day), and high‐dose (5 mg/kg/day) groups. On Postoperative day 7, we assessed flap viability
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An evaluation of the usability and durability of 3D printed versus standard suture materials Wound Repair Regen. (IF 2.9) Pub Date : 2024-03-27 Thang T. Nguyen, Jason G. Langenfeld, Benjamin C. Reinhart, Elizabeth I. Lyden, Abraham S. Campos, Michael C. Wadman, Matthew R. Jamison, Stephen A. Morin, Aaron N. Barksdale
The capability to produce suture material using three‐dimensional (3D) printing technology may have applications in remote health facilities where rapid restocking of supplies is not an option. This is a feasibility study evaluating the usability of 3D‐printed sutures in the repair of a laceration wound when compared with standard suture material. The 3D‐printed suture material was manufactured using
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Outcomes of open reduction and internal fixation of calcaneus fractures: A database study comparing patients with and without diabetes Wound Repair Regen. (IF 2.9) Pub Date : 2024-03-22 Matthew J. Johnson, Benjamin M. Conover, Robert G. Frykberg, Katherine M. Raspovic, Lawrence A. Lavery, Dane K. Wukich
Treatment of calcaneal fractures in patients with diabetes mellitus (DM) is challenging. The purpose of this study was to compare post‐operative outcomes after open reduction and internal fixation (ORIF) for calcaneus fracture in patients with complicated DM, uncomplicated DM, and patients without DM. A commercially available de‐identified database was queried for all calcaneus fracture diagnoses undergoing
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Image‐based non‐invasive assessment of suction blister wounds for clinical safety and efficacy Wound Repair Regen. (IF 2.9) Pub Date : 2024-03-21 Karl Wallblom, Sigrid Lundgren, Karim Saleh, Artur Schmidtchen, Manoj Puthia
Recognising the need for objective imaging‐based technologies to assess wound healing in clinical studies, the suction blister wound model offers an easily accessible wound model that creates reproducible epidermal wounds that heal without scarring. This study provides a comprehensive methodology for implementing and evaluating photography‐based imaging techniques utilising the suction blister wound
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Cryogel wound dressings based on natural polysaccharides perfectly adhere to irregular wounds for rapid haemostasis and easy disassembly Wound Repair Regen. (IF 2.9) Pub Date : 2024-03-18 Changchun Liu, Jiaqi Liu, Minmin Wu, Haifeng Ni, Jie Feng, Liping Zhao, Jing Zhang
Skin injuries can have unexpected surfaces, leading to uneven wound surfaces and inadequate dressing contact with these irregular surfaces. This can decrease the dressing's haemostatic action and increase the healing period. This study recommends the use of sticky and flexible cryogel coverings to promote faster haemostasis and efficiently handle uneven skin wounds. Alginate cryogels have a fast haemostatic
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The effect of VEGF stimulation in diabetic foot ulcers: A systematic review Wound Repair Regen. (IF 2.9) Pub Date : 2024-03-18 Frederik S. Bang, Veronica Leeberg, Ming Ding, Chris H. Dreyer
Diabetic foot ulcers are a common and severe complication of diabetes mellitus, and a risk factor for amputation. Because of the vessel insufficiency in diabetic foot ulcers (DFU), vascular endothelial growth factor (VEGF) that simulates angiogenesis is of interest to promote wound healing. This systematic review evaluates the last 16 years of in‐vivo studies with VEGF stimulation as a treatment for
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Utilizing multiscale engineered biomaterials to examine TGF‐β‐mediated myofibroblastic differentiation Wound Repair Regen. (IF 2.9) Pub Date : 2024-03-09 Aryssa Simpson, Abhichart Krissanaprasit, Daniel Chester, Cynthia Koehler, Thomas H. LaBean, Ashley C. Brown
Cells integrate many mechanical and chemical cues to drive cell signalling responses. Because of the complex nature and interdependency of alterations in extracellular matrix (ECM) composition, ligand density, mechanics, and cellular responses it is difficult to tease out individual and combinatorial contributions of these various factors in driving cell behavior in homeostasis and disease. Tuning
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Bacterial cellulose as an ideal potential treatment for burn wounds: A comprehensive review Wound Repair Regen. (IF 2.9) Pub Date : 2024-03-06 Farzaneh Jabbari, Valiollah Babaeipour
Burn wound regeneration is a complex process, which has many serious challenges such as slow wound healing, secondary infection, and inflammation. Therefore, it is essential to utilise appropriate biomaterials to accelerate and guide the wound healing process. Bacterial cellulose (BC), a natural polymer synthesised by some bacteria, has attracted much attention for wound healing applications due to
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The infected diabetic foot: Analysis of diabetic and non‐diabetic foot infections Wound Repair Regen. (IF 2.9) Pub Date : 2024-03-01 Lawrence A. Lavery, Mehmet A. Suludere, Easton Ryan, Peter A. Crisologo, Arthur Tarricone, Matthew Malone, Orhan K. Oz
The aim of this study was to compare outcomes of moderate and severe foot infections in people with and without diabetes mellitus (DM). We retrospectively evaluated 382 patients (77% with DM and 23% non‐DM). We collected demographic data, co‐morbidities and one‐year outcomes including healing, surgical interventions, number of surgeries, length of stay, re‐infection and re‐hospitalisation. DM patients
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MRSA infection, re‐infection and clinical outcomes in diabetic foot infections Wound Repair Regen. (IF 2.9) Pub Date : 2024-02-29 Mehmet A. Suludere, Orhan K. Öz, Lee C. Rogers, Dane K. Wukich, Matthew Malone, Lawrence A. Lavery
The aim was to investigate methicillin‐resistant Staphylococcus aureus (MRSA) incidence, conversion and outcomes in diabetic foot infections (DFIs). This is a pooled patient‐level analysis of combined data sets from two randomised clinical trials including 219 patients admitted to the hospital with moderate or severe DFIs. Intraoperative bone and tissue cultures identified bacterial pathogens. We identified
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Self‐improving dystrophic epidermolysis bullosa with a novel heterozygous missense variant in the COL7A1 gene in a Taiwanese family Wound Repair Regen. (IF 2.9) Pub Date : 2024-02-28 Yi‐Chia Tsai, Wei‐Ting Tu, Chun‐Lin Su, Yu‐Wen Cheng, Pei‐Ling Chi, Chao‐Kai Hsu, Yang‐Yi Chen
Self‐improving dystrophic epidermolysis bullosa (DEB) is a genodermatosis that is inherited autosomal dominantly or recessively, and its clinical symptoms may improve or subside spontaneously. Herein, we report a case of self‐improving DEB with COL7A1 p.Gly2025Asp variant. The diagnosis was made through histopathological, electron microscopic examination, and genetic testing. The same variant is also
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The proliferative effects of stem cells from apical papilla‐conditioned medium on rat corneal endothelial cells Wound Repair Regen. (IF 2.9) Pub Date : 2024-02-28 Kimia Rahimiyan, Mohammad Hossein Nasr Esfahani, Fereshteh Karamali
The cornea, positioned at the forefront of the eye, refracts the light for focusing images on the retina. Damage to this transparent structure can lead to various visual disorders. The corneal endothelial cells (CECs) are crucial for transparency and homeostasis, but lack the ability to reproduce. Significant damage results in structure destruction and vision impairment. While extensive research has
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An analysis of keloid patient questions on Reddit Wound Repair Regen. (IF 2.9) Pub Date : 2024-02-19 Jennifer Wang, Paras Patel, Jared Jagdeo
Reddit is one of the world's leading social media platforms, fostering active community discussions on a variety of topics including keloids. The prevalence and reach of conversations on Reddit underscore the need to investigate and understand patient perspectives and gaps in knowledge. Herein, we present an in-depth analysis of questions and concerns of Reddit users on keloids, offering valuable insights
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Film-forming polymer solutions containing cholesterol myristate and berberine mediate pressure ulcer repair via the Wnt/β-catenin pathway Wound Repair Regen. (IF 2.9) Pub Date : 2024-02-14 Yu Li, Haiting Huang, Cuijin Gu, Wenyi Huang, Xianxian Chen, Xiaoting Lu, Aijia You, Sen Ye, Jun Zhong, Yao Zhao, Yu Yan, Chun Li
Pressure ulcer (PU) is a worldwide problem that is difficult to address because of the related inflammatory response, local hypoxia, and repeated ischaemia/reperfusion, causing great suffering and financial burden to patients. Traditional Chinese medicine turtle plate powder can treat skin trauma, but its composition is complex and inconvenient to use. Here, we combined cholesterol myristate (S8) with
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Keloids in male genitalia—Systematic review and illustrative case report Wound Repair Regen. (IF 2.9) Pub Date : 2024-02-13 Felipe Contoli Isoldi, Ariane Garcia, Luiza Vieites, Lydia Masako Ferreira
Keloid is the maximum expression of pathological fibroproliferative skin wound healing, whose pathophysiology is not yet fully understood. Its occurrence in the perineum and genitalia is uncommon. A systematic review was carried out regarding the occurrence and treatment of keloids on the penis. An illustrative case was also reported. The review used the PRISMA checklist and was registered in PROSPERO
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Photosensitizer-loaded hydrogels: A new antibacterial dressing Wound Repair Regen. (IF 2.9) Pub Date : 2024-02-03 Shunying Liu, Yanhai Feng, Yang Tan, Jinyi Chen, Tao Yang, Xiaoyu Wang, Lingfei Li, Fangjie Wang, Huaping Liang, Julia-Li Zhong, Chao Qi, Xia Lei
Bacterial wound infection has emerged as a pivotal threat to human health worldwide, and the situation has worsened owing to the gradual increase in antibiotic-resistant bacteria caused by the improper use of antibiotics. To reduce the use of antibiotics and avoid the increase in antibiotic-resistant bacteria, researchers are increasingly paying attention to photodynamic therapy, which uses light to
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Development of pro-angiogenic skin substitutes for wound healing Wound Repair Regen. (IF 2.9) Pub Date : 2024-02-03 Hengyue Song, Dake Hao, Jianda Zhou, Diana Farmer, Aijun Wang
Wounds pose significant challenges to public health, primarily due to the loss of the mechanical integrity and barrier function of the skin and impaired angiogenesis, causing physical morbidities and psychological trauma to affect patients. Reconstructing the vasculature of the wound bed is crucial for promoting wound healing, reducing scar formation and enhancing the quality of life for patients.
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Prevalence and characteristics of pain in patients with lower-extremity ulcers—A cross-sectional study Wound Repair Regen. (IF 2.9) Pub Date : 2024-01-23 Lubna Sabah, Ewa Anna Burian, Klaus Kirketerp-Møller, Simon Francis Thomsen, Finn Borgbjerg Moltke
The study aimed to investigate the prevalence and characteristics of pain in different ulcer types and to identify factors associated with pain experience in patients with lower-extremity ulcers. A cross-sectional single-centre study was performed, including 130 newly referred outpatients with lower-extremity ulcers. Pain intensity was measured with a visual analog scale (VAS) and pain characteristics
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The effects of TGF-β1 and IFN-α2b on decorin, decorin isoforms and type I collagen in hypertrophic scar dermal fibroblasts Wound Repair Regen. (IF 2.9) Pub Date : 2024-01-19 Elizabeth E. Eremenko, Peter O. Kwan, Jie Ding, Sunita Ghosh, Edward E. Tredget
Hypertrophic scars (HTS) develop from an excessive synthesis of structural proteins like collagen and a decreased expression of proteoglycans such as decorin. Previous research has demonstrated that decorin expression is significantly down-regulated in HTS, deep dermal tissue, and thermally injured tissue, reducing its ability to regulate pro-fibrotic transforming growth factor-beta 1 (TGF-β1) and
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Vagus nerve stimulation: Potential for treating chronic wounds Wound Repair Regen. (IF 2.9) Pub Date : 2024-01-18 Anuj Budhiraja, Alisha Mehta, Moyasar A. Alhamo, Richard Swedarsky, Sara Dahle, R. Rivkah Isseroff
Vagus nerve stimulation (VNS) has been approved as a treatment for various conditions, including drug-resistant epilepsy, migraines, chronic cluster headaches and treatment-resistant depression. It is known to have anti-inflammatory, anti-nociceptive and anti-adrenergic effects, and its therapeutic potential for diverse pathologies is being investigated. VNS can be achieved through invasive (iVNS)
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Patterns of use of advanced wound matrices in the Veterans Administration clinics Wound Repair Regen. (IF 2.9) Pub Date : 2024-01-12 Yimeng Lina Du, Pallas Lim, Rivkah Isseroff, Sara Dahle
Chronic wounds are a common and costly health issue affecting millions of individuals in the United States, particularly those with underlying conditions such as diabetes, venous insufficiency, and peripheral artery disease. When standard treatments fail, advanced wound care therapies, such as skin substitutes, are often applied. However, the clinical effectiveness, indications, and comparative benefits
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A recombinant signalling-selective activated protein C that lacks anticoagulant activity is efficacious and safe in cutaneous wound preclinical models Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-29 Ruilong Zhao, Meilang Xue, Haiyan Lin, Margaret Smith, Helena Liang, Hartmut Weiler, John H. Griffin, Christopher J. Jackson
Various preclinical and clinical studies have demonstrated the robust wound healing capacity of the natural anticoagulant activated protein C (APC). A bioengineered APC variant designated 3K3A-APC retains APC's cytoprotective cell signalling actions with <10% anticoagulant activity. This study was aimed to provide preclinical evidence that 3K3A-APC is efficacious and safe as a wound healing agent.
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Evaluating the cost-effectiveness of diabetic foot ulcer management by wound care specialists in Indonesia Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-27 Suriadi Jais, Makoto Oe, Hiromi Sanada, Agung Sasongko, Haryanto Haryanto
Diabetic foot ulcers affect quality of life and economically burden patients and the Indonesian healthcare system. The comparative cost-effectiveness of wound care specialists in private practices (e.g., wound clinics) and wound care nurses in national hospitals remains unknown. Thus, we used a decision tree to compare the cost and healing rates for patients after 12 weeks of wound care. Uncertainty
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The flower of Abelmoschus manihot (L.) medik exerts antioxidant effects by regulating the Nrf2 signalling pathway in scald injury Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-27 Ying Song, Zailin Fu, Xinyi Zhu, Jun Zhang, Wenwen Bai, Biwei Song
Scald is a common skin injury in daily life. It is well known that skin burns are associated with inflammation and oxidative stress. In our previous study, we found that Abelmoschus manihot (L.) medik had excellent therapeutic effects on scald-induced inflammation, but its effect on scald-induced oxidative stress was not reported. In this study, a deep second-degree scald model in mice was established
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Dysfunctional iron metabolism in pressure injuries is related to aberrant CD163 and Homx-1 signal transduction Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-26 Ju Zhang, Hui Shan, Jinglin Guo, Xiaoying Wang, Weiwei Wang
Dysregulation of iron metabolism has been associated with impaired chronic wound healing. However, changes in iron metabolism have yet to be reported in pressure injuries, a type of chronic wound. In this study, we aimed to investigate changes in iron metabolism and associated regulatory mechanisms in pressure injuries. We collected tissue biopsies and data from 20 consenting stage IV-pressure injuries
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Effect of hydrocolloid dressings on preventing air leakage when applying negative pressure wound therapy to the perineum, buttocks, and sacrococcygeal region Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-21 Chao Wang, Rui Li, Xiangpeng Su, Jixun Zhang, Zhenzhong Liu
Maintaining a vacuum when applying negative pressure wound therapy (NPWT) is the key to its function, which is a challenge in the perineum, buttocks, and sacrococcygeal region. A retrospective cohort study was conducted to assess the effect of hydrocolloid dressings on preventing air leakage when applying NPWT in these regions. There were 61 patients in Group A (without the aid of hydrocolloid dressings)
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The use of hyperbaric oxygen therapy in the treatment of hand crush injuries Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-21 Dun-Hao Chang, Chi-Ying Hsieh, Che-Wei Chang, Hsu-Hui Wang, Hou-Tai Chang
Hyperbaric oxygen therapy (HBOT) has been used as an adjuvant treatment for crush injury because it can improve tissue hypoxia and stimulate wound healing. However, the actual role of HBOT in crush hand injury is still unknown. This study is to assess the efficacy of HBOT for crush hand patients, as well as the impact of HBOT initiation timing. Between 2018 and 2021, 72 patients with crush hand injury
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Dendrobium officinale Kinura et Migo glycoprotein promotes skin wound healing by regulating extracellular matrix secretion and fibroblast proliferation on the proliferation phase Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-19 Jia Li, Qian Zhao, Xiaoyu Gao, Tianyi Dai, Zilin Bai, Jun Sheng, Yang Tian, Zhongbin Bai
Dendrobium officinale Kinura et Migo (DOKM) has a variety of medicinal applications; however, its ability to promote wound healing has not been previously reported. The purpose of this study is to investigate the proliferative phase of the wound−healing effect of DOKM glycoprotein (DOKMG) in rats and to elucidate its mechanism of action in vitro. In the present study, the ointment mixture containing
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Evaluating the impact of an anti-microbial silver-impregnated surgical dressing on wound infections and healing: A randomised clinical trial Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-18 Adam Whitley, Peter Baláž, Jan Kavalírek, Jitka Hanusová, Robert Gürlich
StopBac is an innovative silver-impregnated antimicrobial dressing specifically designed to reduce surgical site infections and enhance healing. The primary objective of this study was to compare infection healing rate at 30 days after surgery between primarily closed surgical wounds covered with StopBac and those covered with Cosmorpor, a standard surgical dressing. Between 1.3.2023 and 30.4.2023
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Healing rates and outcomes following closed transmetatarsal amputations: A systematic review and random effects meta-analysis of proportions Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-18 Tyler Coye, Elizabeth Ansert, Mehmet A. Suludere, Jayer Chung, Gu Eon Kang, Lawrence A. Lavery
Transmetatarsal amputation (TMA) is a common surgical procedure for addressing severe forefoot pathologies, such as peripheral vascular disease and diabetic foot infections. Variability in research methodologies and findings within the existing literature has hindered a comprehensive understanding of healing rates and complications following TMA. This meta-analysis and systematic review aims to consolidate
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Human keratin matrices promote wound healing by modulating skin cell expression of cytokines and growth factors Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-18 Allison N. Ramey-Ward, Howard P. Walthall, Shakesia Smith, Thomas H. Barrows
A wide variety of biomaterials has been developed to assist in wound healing, including acellular animal and human-derived protein matrices. However, millions of patients worldwide still suffer from non-healing chronic wounds, demonstrating a need for further innovation in wound care. To address this need, a novel biomaterial, the human keratin matrix (HKM), was developed, characterised, and tested
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Correction to “Recent advances in the induced pluripotent stem cell-based skin regeneration” Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-14
Choudhury S., Surendran N., Das A. Recent advances in the induced pluripotent stem cell-based skin regeneration. Wound Rep Reg. 2021; 29(5): 697–710. https://doi.org/10.1111/wrr.12925. In the article cited above, the authors have identified an error in the affiliation as specified below: The affiliation should be corrected as follows: Academy of Scientific and Innovative Research (AcSIR), Ghaziabad
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Risk factors for venous ulceration in patients with varicose veins of lower extremities Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-12 Chaonan Yin, Fang Tang, Jiahui Lao, Yang Yang, Mingzhuo Li, Jia Cao, Ru Song, Peng Wu, Yibing Wang
The aim of this case–control study was to explore the potential risk factors for venous ulceration in patients with varicose veins of lower extremities and to establish a simplified diagnostic score model. Seventy subjects with varicose veins of lower extremities and venous ulceration were compared with 1164 controls with varicose veins of lower extremities and no history of venous ulceration. Stepwise
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Evaluation of factors affecting the healing process of venous ulcers: A 12-week longitudinal study Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-10 Paulina Mościcka, Justyna Cwajda-Białasik, Arkadiusz Jawień, Wojciech Jaraczewski, Maria T. Szewczyk
The process of healing venous ulcers is complex and influenced by many factors. By identifying the risk factors that influence a slower healing process, it is possible to predict impending delays and plan an individualised care plan. We analysed our database of patients with venous ulcers and identified clinical and demographic factors that delay the healing process. The research analysed the medical
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Healing profiles in patients with a chronic diabetic foot ulcer: An exploratory study with machine learning Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-10 M. Graça Pereira, Margarida Vilaça, Diogo Braga, Ana Madureira, Jéssica Da Silva, Diana Santos, Eugénia Carvalho
Diabetic foot ulcers (DFU) are one of the most frequent and debilitating complications of diabetes. DFU wound healing is a highly complex process, resulting in significant medical, economic and social challenges. Therefore, early identification of patients with a high-risk profile would be important to adequate treatment and more successful health outcomes. This study explores risk assessment profiles
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A substantial number of patients with rest pain, ulceration or gangrene are unable to undergo current non-invasive perfusion testing—Could another modality be utilised? Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-06 Odette Hart, Qiantai Hong, Khai Tuck Lee, Sinead Gormley, Peta Tehan, Jill Sommerset, Manar Khashram
Rest pain, ulceration and gangrene are hallmark features of chronic limb-threatening ischaemia (CLTI). Wound healing can be challenging, and this is compounded by an inability to measure lower limb perfusion via non-invasive tools such as toe pressure (TP). Novel perfusion tests, such as pedal acceleration time (PAT), may overcome some limitations. This study aimed to quantify the proportion of patients
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Secretome of stem cells from human exfoliated deciduous teeth (SHED) and its extracellular vesicles improves keratinocytes migration, viability, and attenuation of H2O2-induced cytotoxicity Wound Repair Regen. (IF 2.9) Pub Date : 2023-12-01 Juliana Girón Bastidas, Natasha Maurmann, Juliete Nathali Scholl, Augusto Ferreira Weber, Raíssa Padilha Silveira, Fabricio Figueiró, Marco Augusto Stimamiglio, Bruna Marcon, Alejandro Correa, Patricia Pranke
Therapies for wound healing using the secretome and extracellular vesicles (EVs) of mesenchymal stem/stromal cells have been shown to be successful in preclinical studies. This study aimed to characterise the protein content of the secretome from stem cells from human exfoliated deciduous teeth (SHED) and analyse the in vitro effects of SHED-conditioned medium (SHED-CM) and SHED extracellular vesicles
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WHS (Wound Healing Society) guidelines update: Diabetic foot ulcer treatment guidelines Wound Repair Regen. (IF 2.9) Pub Date : 2023-11-30 Lawrence A. Lavery, Mehmet A. Suludere, Chris E. Attinger, Matthew Malone, Gu Eon Kang, Peter A. Crisologo, Edgar J. Peters, Lee C. Rogers
CONFLICT OF INTEREST STATEMENT LAL, MAS, CEA, GEK, PAC, EJP, LER have no disclosures. MM is employment with molnlycke healthcare post completion of the guidelines.
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Clinical efficacy and patients’ perception of virtual reality during wound care in adults: A systematic review with meta-analysis of randomised clinical trials Wound Repair Regen. (IF 2.9) Pub Date : 2023-11-23 Masood Mazaheri, Raoul F. Crooijmans, Maya Vereen, Eveline M. L. Corten
This study was aimed to review Virtual Reality's (VR) impact on pain, anxiety, opioid usage, physiological and behavioural responses, and patients’ experience during wound care (WC) in adults. We searched multiple databases (Embase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, CINAHL, Scopus and Google Scholar) from inception until January 27th, 2023
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Letter to editor in response to 'Tian K, Ye J, Zhong Y, Jia Z, Xu W, Gao S, Cao S, Li K, Wu L. Autologous i-PRF promotes healing of radiation-induced skin injury. Wound Repair Regen. 2023;31:454-463'. Wound Repair Regen. (IF 2.9) Pub Date : 2023-11-20 Saravanan Sampoornam Pape Reddy,Delfin Lovelina Francis,Ruchi Harish,Balaji Manohar,Sukhbir Singh Chopra
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WHS guidelines for the treatment of pressure ulcers—2023 update Wound Repair Regen. (IF 2.9) Pub Date : 2023-11-16 Lisa J. Gould, Jenny Alderden, Rummana Aslam, Adrian Barbul, Kath M. Bogie, Mohamed El Masry, Letitia Y. Graves, E. Foy White-Chu, Amany Ahmed, KerriAnn Boanca, Jessica Brash, Katie R. Brooks, Wendy Cockron, Susan M. Kennerly, Aaron K. Livingston, Jeni Page, Catherine Stephens, Velena West, Tracey L. Yap
The major populations at risk for developing pressure ulcers are older adults who have multiple risk factors that increase their vulnerability, people who are critically ill and those with spinal cord injury/disease. The reported prevalence of pressure ulcers in the United States is 2.5 million. However, this estimate is derived from acute care facilities and does not include people who are living
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Development of a double-layer electrospun patch as a potential prenatal treatment for myelomeningocele Wound Repair Regen. (IF 2.9) Pub Date : 2023-11-13 K. Benabdderrahmane, J. Stirnemann, S. Ramtani, C. Falentin-Daudré
Myelomeningocele (MMC) is a congenital defect of the spine characterised by meningeal and spinal cord protrusion through the open vertebral arches. This defect causes progressive prenatal damage of the spinal cord, leading to lifelong handicap. Although mid-trimester surgical repair may reduce part of the handicap, an earlier and less invasive approach would further improve the prognosis, possibly
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A deeper look at low-frequency contact ultrasonic debridement in the clinical management of patients with diabetic foot ulcers Wound Repair Regen. (IF 2.9) Pub Date : 2023-11-13 Francisco J. Álvaro-Afonso, Sebastián Flores-Escobar, David Sevillano-Fernández, Yolanda García-Álvarez, Marta García-Madrid, José L. Lázaro-Martínez
The current study aimed to evaluate the dispersal of solution and microbes (aerosol) in the clinical environment during treatment with Low-frequency contact ultrasonic debridement (LFCUD) with or without suction attachment in patients with diabetic foot ulcers (DFUs). We performed 20 treatments in 10 patients divided into two groups to receive the proposed LFCUD modalities. We measured the microbial
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Nanofibrous polycaprolactone/gelatin scaffold containing gold nanoparticles: Physicochemical and biological characterization for wound healing Wound Repair Regen. (IF 2.9) Pub Date : 2023-11-13 Nariman Rezaei Kolarijani, Danial Cheraghali, Hossein Khastar, Arian Ehterami, Morteza Alizade, Ahmad Vaez, Seyed Mohammad Amini, Majid Salehi
In this study, gold nanoparticles were loaded into poly (ε-caprolactone) (PCL)/gelatin nanofibrous matrices to fabricate a potential wound dressing. The mats were produced by electrospinning of PCL/gelatin solution supplemented with synthesized gold nanoparticles (200, 400 and 800 ppm). Prepared scaffolds were investigated regarding their chemical properties, morphology, mechanical properties, surface
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Uterine scars after caesarean delivery: From histology to the molecular and ultrastructural level Wound Repair Regen. (IF 2.9) Pub Date : 2023-11-13 Alexander Paping, Clara Basler, Loreen Ehrlich, Carlo Fasting, Kerstin Melchior, Thomas Ziska, Mario Thiele, Georg N. Duda, Sara Timm, Matthias Ochs, Rebecca C. Rancourt, Wolfgang Henrich, Thorsten Braun
Uterine rupture during a trial of labor after caesarean delivery (CD) is a serious complication for mother and fetus. The lack of knowledge on histological features and molecular pathways of uterine wound healing has hindered research in this area from evolving over time. We analysed collagen content and turnover in uterine scars on a histological, molecular and ultrastructural level. Therefore, tissue
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Efficacy of wearable vibration dressings on full-thickness wound healing in a hyperglycemic rat model Wound Repair Regen. (IF 2.9) Pub Date : 2023-11-11 Daijiro Haba, Takafumi Ohmiya, Masaki Sekino, Qi Qin, Chihiro Takizawa, Sanai Tomida, Takeo Minematsu, Hiromi Sanada, Gojiro Nakagami
Local low-frequency vibration promotes blood flow and wound healing in hard-to-heal diabetic foot ulcers (DFUs). However, vibration treatment is challenging in patients with DFUs due to wound management difficulties and low adherence. Consequently, developing wearable self-care devices becomes imperative for effective wound healing. This study introduces a wearable vibration dressing and assesses its
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The infected diabetes-related foot: Comparison of erythrocyte sedementation rate/albumin and C-reactive protein/albumin ratios with erythrocyte sedimentation rate and C-reactive protein to differentiate bone and soft tissue infections Wound Repair Regen. (IF 2.9) Pub Date : 2023-10-16 Tyler L. Coye, Mehmet A. Suludere, Gu Eon Kang, P. Andrew Crisologo, Matthew Malone, Lee C. Rogers, Lawrence A. Lavery
The objective of this study was to evaluate the effectiveness of C-reactive protein (CRP)/albumin, erythrocyte sedimentation rate (ESR)/albumin ratio, ESR, CRP and albumin to differentiate bone and soft tissue infection in persons with diabetes. We retrospectively evaluated 242 individuals admitted to hospital with diabetes-related foot infections (DFI). We categorised DFI cases as either bone (OM)
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Progress in copper-based materials for wound healing Wound Repair Regen. (IF 2.9) Pub Date : 2023-10-11 Wuliang Diao, Peiting Li, Xilin Jiang, Jianda Zhou, Songbo Yang
Chronic wounds have become the leading cause of death, particularly among diabetic patients. Chronic wounds affect ~6.5 million patients each year, according to statistics, and wound care and management incur significant financial costs. The rising prevalence of chronic wounds, combined with the limitations of current treatments, necessitates the development of new and innovative approaches to accelerate
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Evaluating skin colour diversity in the validation of scar assessment tools Wound Repair Regen. (IF 2.9) Pub Date : 2023-09-28 Stuti P. Garg, Tokoya Williams, Iulianna C. Taritsa, Rou Wan, Chirag Goel, Raiven Harris, Kristin Huffman, Robert D. Galiano
Across scar studies, there is a lack of dark-skinned individuals, who have a predisposition for keloid formation, altered pigmentation and poorer quality of life (QOL). There is a need for patients of colour to be included in scar scale development and validation. In this study, we evaluate the racial diversity of patients included in the validation of scar assessment scales. A systematic review was
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3D-printed electrospun fibres for wound healing Wound Repair Regen. (IF 2.9) Pub Date : 2023-09-27 Xilin Ye, Enshuo Zhang, Yaqin Huang, Feng Tian, Jiajia Xue
Wound management for acute and chronic wounds has become a serious clinical problem worldwide, placing considerable pressure on public health systems. Owing to the high-precision, adjustable pore structure, and repeatable manufacturing process, 3D-printed electrospun fibre (3DP-ESF) has attracted widespread attention for fabricating wound dressing. In addition, in comparison with 2D electrospun fibre
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Ulrich auf dem Keller (1974–2023) Wound Repair Regen. (IF 2.9) Pub Date : 2023-09-20 Magnus S. Ågren, Boris Hinz, Konstantinos Kalogeropoulos, Christopher M. Overall, Hans Smola, Sabine Werner
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.
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Incidence, prevalence and risk factors of device-related pressure injuries in adult intensive care unit: A meta-analysis of 10,084 patients from 11 countries Wound Repair Regen. (IF 2.9) Pub Date : 2023-08-16 Yi-Jie Jia, Fei-Hong Hu, Wan-Qing Zhang, Wen Tang, Meng-Wei Ge, Wang-Qin Shen, Hong-Lin Chen
Device-related pressure injuries (DRPIs) prevail in the intensive care unit (ICU) and have much to do with medical devices and patients’ conditions. This meta-analysis aims to systematically assess the incidence, prevalence and risk factors related to DRPIs among adults in ICU. Web of Science, Cochrane Library, MEDLINE, PubMed and CINAHL were searched from inception to March 2023. Observational studies
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Risk factors associated with pressure ulcer recurrence after reconstruction: Analysis of a national database Wound Repair Regen. (IF 2.9) Pub Date : 2023-08-15 Alec S. McCranie, Ryan S. Constantine, Nayun Lee, Elliot L. H. Le, Michael Gehring, Matthew L. Iorio
In this study, we sought to clarify the patient traits and comorbidities that are associated with pressure injury recurrence following pressure injury reconstruction. An insurance claims database, PearlDiver, was used to conduct a retrospective cohort study. The two cohorts included patients who underwent pressure injury reconstruction without recurrence and patients who experienced recurrence with