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The Emergency Medical Team Operating System — a vision for field hospital data management in following the concepts of predictive, preventive, and personalized medicine EPMA J. (IF 6.5) Pub Date : 2024-04-22 Jan Gaebel, Erik Schreiber, Thomas Neumuth
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Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation EPMA J. (IF 6.5) Pub Date : 2024-04-18 Olga Golubnitschaja, Andrea Kapinova, Nafiseh Sargheini, Bianka Bojkova, Marko Kapalla, Luisa Heinrich, Eleni Gkika, Peter Kubatka
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Mediterranean diet in the targeted prevention and personalized treatment of chronic diseases: evidence, potential mechanisms, and prospects EPMA J. (IF 6.5) Pub Date : 2024-04-16 Yuji Xiao, Xuefei Xiao, Xue Zhang, Dongxin Yi, Tao Li, Qiangqiang Hao, Feng Zhang, Xu Li, Ningning Wang
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Energy metabolism as the hub of advanced non-small cell lung cancer management: a comprehensive view in the framework of predictive, preventive, and personalized medicine EPMA J. (IF 6.5) Pub Date : 2024-04-08 Ousman Bajinka, Serge Yannick Ouedraogo, Olga Golubnitschaja, Na Li, Xianquan Zhan
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Clinically relevant stratification of lung squamous carcinoma patients based on ubiquitinated proteasome genes for 3P medical approach EPMA J. (IF 6.5) Pub Date : 2024-03-04 Jingru Yang, Serge Yannick Ouedraogo, Jingjing Wang, Zhijun Li, Xiaoxia Feng, Zhen Ye, Shu Zheng, Na Li, Xianquan Zhan
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The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation EPMA J. (IF 6.5) Pub Date : 2024-02-27
Abstract Worldwide stroke is the second leading cause of death and the third leading cause of death and disability combined. The estimated global economic burden by stroke is over US$891 billion per year. Within three decades (1990–2019), the incidence increased by 70%, deaths by 43%, prevalence by 102%, and DALYs by 143%. Of over 100 million people affected by stroke, about 76% are ischemic stroke
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Promoting advanced medical services in the framework of 3PM—a proof-of-concept by the “Centro” Region of Portugal EPMA J. (IF 6.5) Pub Date : 2024-02-22 Fernando J. Regateiro, Henriqueta Silva, Manuel C. Lemos, Gabriela Moura, Pedro Torres, André Dias Pereira, Luís Dias, Pedro L. Ferreira, Sara Amaral, Manuel A. S. Santos
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Cancer screening in hospitalized ischemic stroke patients: a multicenter study focused on multiparametric analysis to improve management of occult cancers EPMA J. (IF 6.5) Pub Date : 2024-02-19 Jie Fang, Jielong Wu, Ganji Hong, Liangcheng Zheng, Lu Yu, Xiuping Liu, Pan Lin, Zhenzhen Yu, Dan Chen, Qing Lin, Chuya Jing, Qiuhong Zhang, Chen Wang, Jiedong Zhao, Xiaodong Yuan, Chunfang Wu, Zhaojie Zhang, Mingwei Guo, Junde Zhang, Jingjing Zheng, Aidi Lei, Tengkun Zhang, Quan Lan, Lingsheng Kong, Xinrui Wang, Zhanxiang Wang, Qilin Ma
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Automated detection of nine infantile fundus diseases and conditions in retinal images using a deep learning system EPMA J. (IF 6.5) Pub Date : 2024-02-15 Yaling Liu, Hai Xie, Xinyu Zhao, Jiannan Tang, Zhen Yu, Zhenquan Wu, Ruyin Tian, Yi Chen, Miaohong Chen, Dimitrios P. Ntentakis, Yueshanyi Du, Tingyi Chen, Yarou Hu, Sifan Zhang, Baiying Lei, Guoming Zhang
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Frailty mediating the causality between leucocyte telomere length and mortality: a cohort study of 440,551 UK Biobank participants EPMA J. (IF 6.5) Pub Date : 2024-02-15 Xuening Jian, Wenxin Sun, Jie Zhang, Qiaoyun Zhang, Xiaoni Meng, Huimin Lu, Deqiang Zheng, Lijuan Wu, Youxin Wang
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Predictive, preventive and personalised approach as a conceptual and technological innovation in primary and secondary care of inflammatory bowel disease benefiting affected individuals and populations EPMA J. (IF 6.5) Pub Date : 2024-02-09
Abstract Inflammatory bowel disease (IBD) is a global health burden which carries lifelong morbidity affecting all age groups in populations with the disease-specific peak of the age groups ranging between 15 and 35 years, which are of great economic importance for the society. An accelerating incidence of IBD is reported for newly industrialised countries, whereas stabilising incidence but increasing
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The mediating effect of perceived stress on the relationship between big five personality traits and suboptimal health status in Chinese population: a nationwide survey in the framework of predictive, preventive, and personalized medicine EPMA J. (IF 6.5) Pub Date : 2023-12-11 Qihua Guan, Hualei Dong, Zhihui Zhang, Zheng Guo, Zi Lin, Hui Niu, Yibo Wu, Haifeng Hou
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Nitroproteomics is instrumental for stratification and targeted treatments of astrocytoma patients: expert recommendations for advanced 3PM approach with improved individual outcomes EPMA J. (IF 6.5) Pub Date : 2023-12-06 Wenshuang Jia, Xiaoxia Gong, Zhen Ye, Na Li, Xianquan Zhan
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Impacts of a multipurpose outpatient hospital pharmacy in the framework of 3P medicine EPMA J. (IF 6.5) Pub Date : 2023-12-04 Lara González Freire, Ana Belen Veiga Villaverde, Ana Ballester Vieitez, Rosario Olivera Fernández, Carlos Crespo-Diz
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Diabetes, glycemic control and arterial stiffness: a real-world cohort study in the context of predictive, preventive, and personalized medicine EPMA J. (IF 6.5) Pub Date : 2023-11-24 Cancan Cui, Te Zhang, Yitian Qi, Jiaqi Chu, Haikun Xu, Chen Sun, Zhenming Zhang, Xingang Wang, Siqi Yue, Xiaoping Kang, Ling Fang
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The predictive, preventive, and personalized medicine of insomnia: gut microbiota and inflammation EPMA J. (IF 6.5) Pub Date : 2023-11-17 Hao-Wen Chen, Rui Zhou, Bi-Fei Cao, Kuan Liu, Qi Zhong, Yi-Ning Huang, Hua-Min Liu, Jin-Qing Zhao, Xian-Bo Wu
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Artificial intelligence to improve ischemia prediction in Rubidium Positron Emission Tomography—a validation study EPMA J. (IF 6.5) Pub Date : 2023-11-15 Simon M. Frey, Adam Bakula, Andrew Tsirkin, Vasily Vasilchenko, Peter Ruff, Caroline Oehri, Melissa Fee Amrein, Gabrielle Huré, Klara Rumora, Ibrahim Schäfer, Federico Caobelli, Philip Haaf, Christian E. Mueller, Bjoern Andrew Remppis, Hans-Peter Brunner-La Rocca, Michael J. Zellweger
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Conceptualised psycho-medical footprint for health status outcomes and the potential impacts for early detection and prevention of chronic diseases in the context of 3P medicine EPMA J. (IF 6.5) Pub Date : 2023-11-08 Ebenezer Afrifa-Yamoah, Eric Adua, Enoch Odame Anto, Emmanuel Peprah-Yamoah, Victor Opoku-Yamoah, Emmanuel Aboagye, Rashid Hashmi
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Predicting 1-, 3-, 5-, and 8-year all-cause mortality in a community-dwelling older adult cohort: relevance for predictive, preventive, and personalized medicine EPMA J. (IF 6.5) Pub Date : 2023-11-03 Yequn Chen, Xiulian Deng, Dong Lin, Peixuan Yang, Shiwan Wu, Xidong Wang, Hui Zhou, Ximin Chen, Xiaochun Wang, Weichai Wu, Kaibing Ke, Wenjia Huang, Xuerui Tan
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Emerging frontiers of artificial intelligence and machine learning in ischemic stroke: a comprehensive investigation of state-of-the-art methodologies, clinical applications, and unraveling challenges EPMA J. (IF 6.5) Pub Date : 2023-11-02 Yishu Fan, Zhenshan Song, Mengqi Zhang
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Causal relationship between gut Prevotellaceae and risk of sepsis: a two-sample Mendelian randomization and clinical retrospective study in the framework of predictive, preventive, and personalized medicine EPMA J. (IF 6.5) Pub Date : 2023-10-12 Yinghao Luo, Yang Zhou, Pengfei Huang, Qianqian Zhang, Feiyu Luan, Yahui Peng, Jieling Wei, Nana Li, Chunying Wang, Xibo Wang, Jiannan Zhang, Kaijiang Yu, Mingyan Zhao, Changsong Wang
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Development and validation of a short-form suboptimal health status questionnaire EPMA J. (IF 6.5) Pub Date : 2023-09-12 Shuyu Sun, Hongzhi Liu, Zheng Guo, Qihua Guan, Yinghao Wang, Jie Wang, Yan Qi, Yuxiang Yan, Youxin Wang, Jun Wen, Haifeng Hou
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Identification of novel serum protein biomarkers in the context of 3P medicine for intravenous leiomyomatosis: a data-independent acquisition mass spectrometry-based proteomics study EPMA J. (IF 6.5) Pub Date : 2023-09-04 Zhitong Ge, Penghui Feng, Zijuan Zhang, Zhiyong Liang, Rong Chen, Jianchu Li
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Machine learning–couched treatment algorithms tailored to individualized profile of patients with primary anterior chamber angle closure predisposed to the glaucomatous optic neuropathy EPMA J. (IF 6.5) Pub Date : 2023-08-17 Natalia I. Kurysheva, Oxana Y. Rodionova, Alexey L. Pomerantsev, Galina A. Sharova, Olga Golubnitschaja
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The correlation between primary open-angle glaucoma (POAG) and gut microbiota: a pilot study towards predictive, preventive, and personalized medicine EPMA J. (IF 6.5) Pub Date : 2023-08-11 Si Chen, Nan Wang, Siqi Xiong, Xiaobo Xia
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Quantitative phosphoproteomics reveals molecular pathway network alterations in human early-stage primary hepatic carcinomas: potential for 3P medical approach EPMA J. (IF 6.5) Pub Date : 2023-08-10 Yuping Zhang, Na Li, Lamei Yang, Wenshuang Jia, Zhijun Li, Qianwen Shao, Xianquan Zhan
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Identifying oxidative stress-related biomarkers in idiopathic pulmonary fibrosis in the context of predictive, preventive, and personalized medicine using integrative omics approaches and machine-learning strategies EPMA J. (IF 6.5) Pub Date : 2023-07-31 Fan Yang, Wendusubilige, Jingwei Kong, Yuhan Zong, Manting Wang, Chuanqing Jing, Zhaotian Ma, Wanyang Li, Renshuang Cao, Shuwen Jing, Jie Gao, Wenxin Li, Ji Wang
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Royal jelly: a predictive, preventive and personalised strategy for novel treatment options in non-communicable diseases EPMA J. (IF 6.5) Pub Date : 2023-07-18 Beatriz G. Baptista, Ligia S. Lima, Marcia Ribeiro, Isadora K. Britto, Livia Alvarenga, Julie A. Kemp, Ludmila FMF Cardozo, Andresa A. Berretta, Denise Mafra
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COVID-19 lessons to protect populations against future pandemics by implementing PPPM principles in healthcare EPMA J. (IF 6.5) Pub Date : 2023-07-14 Cuihong Tian, Lois Balmer, Xuerui Tan
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Anatomic characteristics of shoulder based on MRI accurately predict incomplete rotator cuff injuries in patients: relevance for predictive, preventive, and personalized healthcare strategies EPMA J. (IF 6.5) Pub Date : 2023-07-13 Hangxing Wu, Zhijie Zuo, Yucong Li, Haoqiang Song, Wanyan Hu, Jingle Chen, Chao Xie, Lijun Lin
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Genetically predicted the causal relationship between gut microbiota and infertility: bidirectional Mendelian randomization analysis in the framework of predictive, preventive, and personalized medicine EPMA J. (IF 6.5) Pub Date : 2023-07-07 Yujia Xi, Chenwei Zhang, Yiqian Feng, Shurui Zhao, Yukai Zhang, Guosheng Duan, Wei Wang, Jingqi Wang
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Ubiquitinomics revealed disease- and stage-specific patterns relevant for the 3PM approach in human sigmoid colon cancers EPMA J. (IF 6.5) Pub Date : 2023-06-30 Hua Yang, Na Li, Liang Chen, Lei Zhou, Yuanchen Zhou, Jixiang Liu, Wenshuang Jia, Ruofei Chen, Junwen Su, Lamei Yang, Xiaoxia Gong, Xianquan Zhan
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Growth hormone proteoformics atlas created to promote predictive, preventive, and personalized approach in overall management of pituitary neuroendocrine tumors EPMA J. (IF 6.5) Pub Date : 2023-06-27 Lamei Yang, Chunling Li, Tao Song, Xianquan Zhan
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Quality of life and cost-effectiveness of different breast cancer surgery procedures: a Markov decision tree-based approach in the framework of Predictive, Preventive, and Personalized Medicine EPMA J. (IF 6.5) Pub Date : 2023-06-14 Hon-Yi Shi, Chiu-Hui Li, Yen-Chen Chen, Chong-Chi Chiu, Hao-Hsien Lee, Ming-Feng Hou
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Mechanical power normalized to aerated lung predicts noninvasive ventilation failure and death and contributes to the benefits of proning in COVID-19 hypoxemic respiratory failure EPMA J. (IF 6.5) Pub Date : 2023-06-10 Giovanni Musso, Claudio Taliano, Marco De Iuliis, Elena Paschetta, Caterina Fonti, Andrea Ferraris, Marta Druetta, Ines Sarah Vianou, Francesca Ranghino, Federica Riedo, Davide Deangelis, Gloria Tirabassi
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Multi-omics identification of an immunogenic cell death-related signature for clear cell renal cell carcinoma in the context of 3P medicine and based on a 101-combination machine learning computational framework EPMA J. (IF 6.5) Pub Date : 2023-05-31 Jinsong Liu, Yanjia Shi, Yuxin Zhang
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Multi-faceted CRISPR/Cas technological innovation aspects in the framework of 3P medicine EPMA J. (IF 6.5) Pub Date : 2023-05-22 Vincent Lučanský, Veronika Holubeková, Zuzana Kolková, Erika Halašová, Marek Samec, Olga Golubnitschaja
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Clarifying the effect of gut microbiota on allergic conjunctivitis risk is instrumental for predictive, preventive, and personalized medicine: a Mendelian randomization analysis EPMA J. (IF 6.5) Pub Date : 2023-05-22 Kangcheng Liu, Yingjun Cai, Kun Song, Ruolan Yuan, Jing Zou
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Underexplored reciprocity between genome-wide methylation status and long non-coding RNA expression reflected in breast cancer research: potential impacts for the disease management in the framework of 3P medicine EPMA J. (IF 6.5) Pub Date : 2023-05-22 Andrea Kapinova, Alena Mazurakova, Erika Halasova, Zuzana Dankova, Dietrich Büsselberg, Vincenzo Costigliola, Olga Golubnitschaja, Peter Kubatka
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Ideal cardiovascular health metrics and life expectancy free of cardiovascular diseases: a prospective cohort study EPMA J. (IF 6.5) Pub Date : 2023-05-20 Qiuyue Tian, Shuohua Chen, Jie Zhang, Cancan Li, Shouling Wu, Yanxiu Wang, Youxin Wang
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Identification of potential necroinflammation-associated necroptosis-related biomarkers for delayed graft function and renal allograft failure: a machine learning-based exploration in the framework of predictive, preventive, and personalized medicine EPMA J. (IF 6.5) Pub Date : 2023-04-28 Qing Bi, Ji-Yue Wu, Xue-Meng Qiu, Yu-Qing Li, Yu-Yao Yan, Ze-Jia Sun, Wei Wang
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Development and validation of a routine blood parameters-based model for screening the occurrence of retinal detachment in high myopia in the context of PPPM EPMA J. (IF 6.5) Pub Date : 2023-03-15 Shengjie Li, Meiyan Li, Jianing Wu, Yingzhu Li, Jianping Han, Wenjun Cao, Xingtao Zhou
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Short communication: unique metabolic signature of proliferative retinopathy in the tear fluid of diabetic patients with comorbidities — preliminary data for PPPM validation EPMA J. (IF 6.5) Pub Date : 2023-02-22 Martina Kropp, Eline De Clerck, Trong-Tin Kevin Steve Vo, Gabriele Thumann, Vincenzo Costigliola, Olga Golubnitschaja
Type 2 diabetes (T2DM) defined as the adult-onset type that is primarily not insulin-dependent, comprises over 95% of all diabetes mellitus (DM) cases. According to global records, 537 million adults aged 20-79 years are affected by DM that means at least 1 out of 15 persons. This number is projected to grow by 51% by the year 2045. One of the most common complications of T2DM is diabetic retinopathy
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Multi-omics and immune cells’ profiling of COVID-19 patients for ICU admission prediction: in silico analysis and an integrated machine learning-based approach in the framework of Predictive, Preventive, and Personalized Medicine EPMA J. (IF 6.5) Pub Date : 2023-02-21 Kun Zhu, Zhonghua Chen, Yi Xiao, Dengming Lai, Xiaofeng Wang, Xiangming Fang, Qiang Shu
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New insight of metabolomics in ocular diseases in the context of 3P medicine EPMA J. (IF 6.5) Pub Date : 2023-02-17 Quyan Zhang, Nan Wang, Yuhua Rui, Yang Xia, Siqi Xiong, Xiaobo Xia
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Vascular dysregulation in glaucoma: retinal vasoconstriction and normal neurovascular coupling in altitudinal visual field defects EPMA J. (IF 6.5) Pub Date : 2023-02-16 Wanshu Zhou, Bernhard A. Sabel
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Integrating oculomics with genomics reveals imaging biomarkers for preventive and personalized prediction of arterial aneurysms EPMA J. (IF 6.5) Pub Date : 2023-02-13 Yu Huang, Cong Li, Danli Shi, Huan Wang, Xianwen Shang, Wei Wang, Xueli Zhang, Xiayin Zhang, Yijun Hu, Shulin Tang, Shunming Liu, Songyuan Luo, Ke Zhao, Ify R. Mordi, Alex S. F. Doney, Xiaohong Yang, Honghua Yu, Xin Li, Mingguang He
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Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation EPMA J. (IF 6.5) Pub Date : 2023-02-13 Martina Kropp, Olga Golubnitschaja, Alena Mazurakova, Lenka Koklesova, Nafiseh Sargheini, Trong-Tin Kevin Steve Vo, Eline de Clerck, Jiri Polivka, Pavel Potuznik, Jiri Polivka, Ivana Stetkarova, Peter Kubatka, Gabriele Thumann
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Microsatellite instability assessment is instrumental for Predictive, Preventive and Personalised Medicine: status quo and outlook EPMA J. (IF 6.5) Pub Date : 2023-01-25 Jakub Styk, Zuzana Pös, Ondrej Pös, Jan Radvanszky, Evelina Hrckova Turnova, Gergely Buglyó, Daniela Klimova, Jaroslav Budis, Vanda Repiska, Bálint Nagy, Tomas Szemes
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Clarifying sleep characteristics and analyzing risk factors of sleep disorders to promote a predictive, preventive, and personalized medicine in patients with burn scars EPMA J. (IF 6.5) Pub Date : 2023-01-09 Huazhen Liu, Futing Shu, Chao Ji, Haiting Xu, Zixuan Zhou, Yuxiang Wang, Haojie Gao, Pengfei Luo, Yongjun Zheng, Kaiyang Lv, Shichu Xiao
Purpose This study assessed sleep quality in patients with burn scars and investigated risk factors of sleep disorders to guide clinical therapy. From the strategy of predictive, preventive, and personalized medicine (PPPM/3PM), we proposed that risk assessment based on clinical indicators could prompt primary prediction, targeted prevention, and personalized interventions to improve the management
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Association of IgG N-glycomics with prevalent and incident type 2 diabetes mellitus from the paradigm of predictive, preventive, and personalized medicine standpoint EPMA J. (IF 6.5) Pub Date : 2022-12-24 Xiaoni Meng, Fei Wang, Xiangyang Gao, Biyan Wang, Xizhu Xu, Youxin Wang, Wei Wang, Qiang Zeng
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Diagnostic accuracy of autoverification and guidance system for COVID-19 RT-PCR results EPMA J. (IF 6.5) Pub Date : 2022-12-16 Yingmu Cai, Mengyu Liu, Zhiyuan Wu, Cuihong Tian, Song Qiu, Zhen Li, Feng Xu, Wei Li, Yan Zheng, Aijuan Xu, Longxu Xie, Xuerui Tan
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Global burden of cancers attributable to tobacco smoking, 1990–2019: an ecological study EPMA J. (IF 6.5) Pub Date : 2022-12-15 Rajesh Sharma, Bijoy Rakshit
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Body mass index–based predictions and personalized clinical strategies for colorectal cancer in the context of PPPM EPMA J. (IF 6.5) Pub Date : 2022-12-02 Yun-Jia Gu, Li-Ming Chen, Mu-En Gu, Hong-Xiao Xu, Jing Li, Lu-Yi Wu
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Comprehensive multi-omics analysis of the m7G in pan-cancer from the perspective of predictive, preventive, and personalized medicine. EPMA J. (IF 6.5) Pub Date : 2022-11-22 Xiaoliang Huang,Zuyuan Chen,Xiaoyun Xiang,Yanling Liu,Xingqing Long,Kezhen Li,Mingjian Qin,Chenyan Long,Xianwei Mo,Weizhong Tang,Jungang Liu
Background The N7-methylguanosine modification (m7G) of the 5' cap structure in the mRNA plays a crucial role in gene expression. However, the relation between m7G and tumor immune remains unclear. Hence, we intended to perform a pan-cancer analysis of m7G which can help explore the underlying mechanism and contribute to predictive, preventive, and personalized medicine (PPPM / 3PM). Methods The gene
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Predictive, preventive, and personalized management of retinal fluid via computer-aided detection app for optical coherence tomography scans EPMA J. (IF 6.5) Pub Date : 2022-11-19 Ten Cheer Quek, Kengo Takahashi, Hyun Goo Kang, Sahil Thakur, Mihir Deshmukh, Rachel Marjorie Wei Wen Tseng, Helen Nguyen, Yih-Chung Tham, Tyler Hyungtaek Rim, Sung Soo Kim, Yasuo Yanagi, Gerald Liew, Ching-Yu Cheng
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Ischemic stroke of unclear aetiology: a case-by-case analysis and call for a multi-professional predictive, preventive and personalised approach EPMA J. (IF 6.5) Pub Date : 2022-11-17 Olga Golubnitschaja, Pavel Potuznik, Jiri Polivka, Martin Pesta, Olga Kaverina, Claus C. Pieper, Martina Kropp, Gabriele Thumann, Carl Erb, Alexander Karabatsiakis, Ivana Stetkarova, Jiri Polivka, Vincenzo Costigliola
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Identification of FERMT1 and SGCD as key marker in acute aortic dissection from the perspective of predictive, preventive, and personalized medicine EPMA J. (IF 6.5) Pub Date : 2022-11-14 Mierxiati Ainiwan, Qi Wang, Gulinazi Yesitayi, Xiang Ma
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Predictive genomic tools in disease stratification and targeted prevention: a recent update in personalized therapy advancements EPMA J. (IF 6.5) Pub Date : 2022-11-12 Neha Jain, Upendra Nagaich, Manisha Pandey, Dinesh Kumar Chellappan, Kamal Dua
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Radiomics based on readout-segmented echo-planar imaging (RS-EPI) diffusion-weighted imaging (DWI) for prognostic risk stratification of patients with rectal cancer: a two-centre, machine learning study using the framework of predictive, preventive, and personalized medicine EPMA J. (IF 6.5) Pub Date : 2022-11-12 Zonglin Liu, Yueming Wang, Fu Shen, Zhiyuan Zhang, Jing Gong, Caixia Fu, Changqing Shen, Rong Li, Guodong Jing, Sanjun Cai, Zhen Zhang, Yiqun Sun, Tong Tong