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Retraction notice to “Transfer of microRNA-221 from mesenchymal stem cell-derived extracellular vesicles inhibits atherosclerotic plaque formation” [Transl. Res. 226 (2020) 83–95] Transl. Res. (IF 7.8) Pub Date : 2024-04-11 Ziyuan Guo, Zhuo Zhao, Chuang Yang, Chunli Song
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Transcriptomic profiling of sciatic nerves and dorsal root ganglia reveals site-specific effects of prediabetic neuropathy Transl. Res. (IF 7.8) Pub Date : 2024-03-29 Stéphanie A. Eid, Sarah E. Elzinga, Kai Guo, Lucy M. Hinder, John M. Hayes, Crystal M. Pacut, Emily J. Koubek, Junguk Hur, Eva L. Feldman
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Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury Transl. Res. (IF 7.8) Pub Date : 2024-03-29 Hanlin Yao, Hongchao Zhao, Yang Du, Ye Zhang, Yanze Li, Hengcheng Zhu
The prevalence of renal ischemia/reperfusion injury (IRI) in premenopausal women is considerably lower than that in age-matched men. This suggests that sex-related differences in mitochondrial function and homeostasis may contribute to sexual dimorphism in renal injury, though the mechanism remains unclear. Mouse model of unilateral left renal IRI with contralateral kidney enucleation, Ovariectomy
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A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein Transl. Res. (IF 7.8) Pub Date : 2024-03-27 Sixian Chen, Qingyun Zhao, Ruirui Zhang, Jungang Liu, Wenyi Peng, Haotian Xu, Xiaofei Li, Xin Wang, Shuilian Wu, Gang Li, Aruo Nan
The transcribed ultraconserved region (T-UCR) belongs to a new type of lncRNAs that are conserved in homologous regions of the rat, mouse and human genomes. A lot of research has reported that differential expression of T-UCRs can influence the development of various cancers, revealing the ability of T-UCRs as new therapeutic targets or potential cancer biomarkers. Most studies on the molecular mechanisms
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Endothelial ELABELA improves post-ischemic angiogenesis by upregulating VEGFR2 expression Transl. Res. (IF 7.8) Pub Date : 2024-03-26 Jia-Yu Peng, Xiao Fu, Xue-Yang Luo, Fang Liu, Bing Zhang, Bin Zhou, Kun Sun, Alex F. Chen
Post-ischemic angiogenesis is critical for perfusion recovery and tissue repair. ELABELA (ELA) plays an essential role in embryonic heart development and vasculogenesis. However, the mechanism of ELA on post-ischemic angiogenesis is poorly characterized. We first assessed ELA expression after hind limb ischemia (HLI) in mice. We then established a HLI model in tamoxifen-inducible endothelial-ELA-specific
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The LPS-inactivating enzyme acyloxyacyl hydrolase protects the brain from experimental stroke Transl. Res. (IF 7.8) Pub Date : 2024-03-22 Yuanbo Zhu, Yue Hu, Zhongwang Liu, Luping Chang, Xue Geng, Xuhui Yin, Bing-Qiao Zhao, Wenying Fan
Blood-brain-barrier (BBB) disruption is a pathological hallmark of ischemic stroke, and inflammation occurring at the BBB contributes to the pathogenesis of ischemic brain injury. Lipopolysaccharide (LPS), a cell wall component of Gram-negative bacteria, is elevated in patients with acute stroke. The activity of LPS is controlled by acyloxyacyl hydrolase (AOAH), a host enzyme that deacylates LPS to
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Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway Transl. Res. (IF 7.8) Pub Date : 2024-03-16 Pratikshya Sa, Priya Singh, Sudhakar Panda, Rajeeb K. Swain, Rupesh Dash, Sanjeeb Kumar Sahoo
Cisplatin alone or in combination with 5FU and docetaxel is the preferred chemotherapy regimen for advanced-stage OSCC patients. However, its use has been linked to recurrence and metastasis due to the development of drug resistance. Therefore, sensitization of cancer cells to conventional chemotherapeutics can be an effective strategy to overcome drug resistance. Piperlongumine (PL), an alkaloid,
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Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy Transl. Res. (IF 7.8) Pub Date : 2024-03-15 Baicheng Kuang, Mengqin Wang, Hao Yan, Qin Jiang, Zhiheng Wang, Haiqiang Ni, Shuaiheng Hou, Xuan Peng, Shiqi Gu, Yuanyuan Zhao, Tongwen Ou, Nianqiao Gong
Hepatic ischemia reperfusion (I/R) injury is a common clinical complication. X-box binding protein 1 (XBP1), as a critical regulator of the endoplasmic reticulum stress, has been implicated in a variety of diseases. In this study, we aimed to investigate the effects and the underlying mechanism of XBP1 in the progression of hepatic I/R injury. Hepatocyte-specific XBP1 knockout mice, multiple viral
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The pregnancy-associated protein glycodelin as a potential sex-specific target for resistance to immunotherapy in non-small cell lung cancer Transl. Res. (IF 7.8) Pub Date : 2024-03-13 Sarah Richtmann, Sebastian Marwitz, Thomas Muley, Hannu Koistinen, Petros Christopoulos, Michael Thomas, Daniel Kazdal, Michael Allgäuer, Hauke Winter, Torsten Goldmann, Michael Meister, Ursula Klingmüller, Marc A. Schneider
Lung cancer has been shown to be targetable by novel immunotherapies which reactivate the immune system and enable tumor cell killing. However, treatment failure and resistance to these therapies is common. Consideration of sex as a factor influencing therapy resistance is still rare. We hypothesize that the success of the treatment is impaired by the presence of the immunosuppressive pregnancy-associated
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PCSK9 inhibition protects mice from food allergy Transl. Res. (IF 7.8) Pub Date : 2024-03-11 Victoria Lorant, Martin Klein, Damien Garçon, Thibaud Sotin, Samuel Frey, Marie-Aude Cheminant, Audrey Ayer, Mikaël Croyal, Laurent Flet, Antoine Rimbert, Luc Colas, Bertrand Cariou, Grégory Bouchaud, Cédric Le May
The Proprotein Convertase Subtilisin Kexin of type 9 (PCSK9) has been identified in 2003 as the third gene involved in familial hypercholesterolemia. PCSK9 binds to the membrane low-density lipoprotein receptor (LDLR) and promotes its cellular internalization and lysosomal degradation. Beyond this canonical role, PCSK9 was recently described to be involved in several immune responses. However, to date
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RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis Transl. Res. (IF 7.8) Pub Date : 2024-03-05 Yu Zhang, Yiqiong Yang, Xiuxiu Hu, Bizhen Wei, Qian Shen, Chuanbing Shi, Pingsheng Chen
The progression of chronic kidney disease (CKD) often involves renal interstitial fibrosis (RIF) and subsequent loss of peritubular capillaries (PTCs), which enhances disease severity. Despite advancements in our understanding of fibrosis, effective interventions for reversing capillary loss remain elusive. Notably, RIF exhibits reduced capillary density, whereas renal cell carcinoma (RCC) shows robust
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Arginine methylation and respiratory disease Transl. Res. (IF 7.8) Pub Date : 2024-03-05 Binbin Zhang, Youhong Guan, Daxiong Zeng, Ran Wang
Arginine methylation, a vital post-translational modification, plays a pivotal role in numerous cellular functions such as signal transduction, DNA damage response and repair, regulation of gene transcription, mRNA splicing, and protein interactions. Central to this modification is the role of protein arginine methyltransferases (PRMTs), which have been increasingly recognized for their involvement
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Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment Transl. Res. (IF 7.8) Pub Date : 2024-02-23 Yuya Yoshida, Kohei Fukuoka, Miyu Sakugawa, Masayuki Kurogi, Kengo Hamamura, Keika Hamasaki, Fumiaki Tsurusaki, Kurumi Sotono, Takumi Nishi, Taiki Fukuda, Taisei Kumamoto, Kosuke Oyama, Takashi Ogino, Akito Tsuruta, Kouta Mayanagi, Tomohiro Yamashita, Hiroyuki Fuchino, Nobuo Kawahara, Kayo Yoshimatsu, Hitomi Kawakami, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo
Chronic kidney disease (CKD) induces cardiac inflammation and fibrosis and reduces survival. We previously demonstrated that G protein-coupled receptor 68 (GPR68) promotes cardiac inflammation and fibrosis in mice with 5/6 nephrectomy (5/6Nx) and patients with CKD. However, no method of GPR68 inhibition has been found that has potential for therapeutic application. Here, we report that extract and
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Elevated expression of complement factor I in lung cancer cells associates with shorter survival–Potentially via non-canonical mechanism Transl. Res. (IF 7.8) Pub Date : 2024-02-22 Anna Felberg, Michał Bieńkowski, Tomasz Stokowy, Kamil Myszczyński, Zuzanna Polakiewicz, Kamila Kitowska, Rafał Sądej, Frida Mohlin, Alicja Kuźniewska, Daria Kowalska, Grzegorz Stasiłojć, Ilse Jongerius, Robbert Spaapen, Miguel Mesa-Guzman, Luis M. Montuenga, Anna M. Blom, Ruben Pio, Marcin Okrój
While numerous membrane-bound complement inhibitors protect the body's cells from innate immunity's autoaggression, soluble inhibitors like complement factor I (FI) are rarely produced outside the liver. Previously, we reported the expression of FI in non-small cell lung cancer (NSCLC) cell lines. Now, we assessed the content of FI in cancer biopsies from lung cancer patients and associated the results
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Characterization of the plasma proteomic profile of Fabry disease: Potential sex- and clinical phenotype-specific biomarkers Transl. Res. (IF 7.8) Pub Date : 2024-02-21 Laura López-Valverde, María E. Vázquez-Mosquera, Cristóbal Colón-Mejeras, Susana B. Bravo, Sofía Barbosa-Gouveia, J. Víctor Álvarez, Rosario Sánchez-Martínez, Manuel López-Mendoza, Mónica López-Rodríguez, Eduardo Villacorta-Argüelles, María A. Goicoechea-Diezhandino, Francisco J. Guerrero-Márquez, Saida Ortolano, Elisa Leao-Teles, Álvaro Hermida-Ameijeiras, María L. Couce
Fabry disease (FD) is a X-linked rare lysosomal storage disorder caused by deficient α-galactosidase A (α-GalA) activity. Early diagnosis and the prediction of disease course are complicated by the clinical heterogeneity of FD, as well as by the frequently inconclusive biochemical and genetic test results that do not correlate with clinical course. We sought to identify potential biomarkers of FD to
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Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling Transl. Res. (IF 7.8) Pub Date : 2024-02-21 Zhi-Xing Wei, Xing-Xing Cai, Yu-Dong Fei, Qian Wang, Xiao-Liang Hu, Cheng Li, Jian-Wen Hou, Yu-Li Yang, Yue-Peng Wang, Yi-Gang Li
Pulmonary hypertension (PH) is a severe clinical syndrome with pulmonary vascular remodeling and poor long-term prognosis. Neurotensin receptor 1 (Ntsr1), serve as one of the G protein-coupled receptors (GPCRs), implicates in various biological processes, but the potential effects of Ntsr1 in PH development are unclear. The Sugen/Hypoxia (SuHx) or monocrotaline (MCT) induced rat PH model was used in
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Nebulized platelet-derived extracellular vesicles attenuate chronic cigarette smoke-induced murine emphysema Transl. Res. (IF 7.8) Pub Date : 2024-02-06 Weixia Xuan, Shaohua Wang, Amarilys Alarcon-Calderon, Monique Simone Bagwell, Rachel Para, Faping Wang, Chujie Zhang, Xue Tian, Paul Stalboerger, Timothy Peterson, Michael S. Sabbah, Zeji Du, Tiffany Sarrafian, Ryan Mahlberg, Matthew L. Hillestad, Skylar A. Rizzo, Christopher R. Paradise, Atta Behfar, Robert Vassallo
Chronic obstructive pulmonary disease (COPD) is a prevalent lung disease usually resulting from cigarette smoking (CS). Cigarette smoking induces oxidative stress, which causes inflammation and alveolar epithelial cell apoptosis and represents a compelling therapeutic target for COPD. Purified human platelet-derived exosome product (PEP) is endowed with antioxidant enzymes and immunomodulatory molecules
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Targeting a cardiac abundant and fibroblasts-specific piRNA (CFRPi) to attenuate and reverse cardiac fibrosis in pressure-overloaded heart failure Transl. Res. (IF 7.8) Pub Date : 2024-02-01 Bo Chen, Bozhong Shi, Zijie Zhou, Yue Cui, Guowei Zeng, Lingyan Cheng, Xiaoyang Zhang, Kai Luo, Cong Li, Zhongqun Zhu, Zhifang Zhang, Jinghao Zheng, Xiaomin He
Cardiac fibrosis under chronic pressure overload is an end-stage adverse remodeling of heart. However, current heart failure treatments barely focus on anti-fibrosis and the effects are limited. We aimed to seek for a cardiac abundant and cardiac fibrosis specific piRNA, exploring its underlying mechanism and therapeutic potential. Whole transcriptome sequencing and the following verification experiments
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Reducing SULT2B1 promotes the interaction of LncRNAgga3-204 with SMAD4 to inhibit the macrophage inflammatory response and delay atherosclerosis progression Transl. Res. (IF 7.8) Pub Date : 2024-01-28 Hangyu Pan, Tongwei Wu, Kang Huang, Zhongzhou Guo, Hongbin Liang, Ping Lyu, Hui Huang, Xinyi Feng, Qianqian Wang, Jing Hu, Yihua He, Zhigang Guo, Mengzhuo Yin, Yanan Zhang
Inflammation is a crucial pathophysiological mechanism in atherosclerosis (AS). This study aims to investigate the impact of sulfotransferase family 2b member 1 (SULT2B1) on the inflammatory response of macrophages and the progression of AS. Here, we reported that SULT2B1 expression increased with the progression of AS. In AS model mice, knockdown of led to remission of AS and reduced inflammation
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Metabolic reprogramming driven by METTL1-mediated tRNA m7G modification promotes acquired anlotinib resistance in oral squamous cell carcinoma Transl. Res. (IF 7.8) Pub Date : 2024-01-26 Jie Chen, Qimin Zhou, Shuai Li, Rongsong Ling, Yiwei Zhao, Demeng Chen, Anxun Wang, Yang Cao
Tyrosine kinase inhibitors (TKIs) are frequently utilized in the management of malignant tumors. Studies have indicated that anlotinib has a significant inhibitory effect on oral squamous cell carcinoma (OSCC). However, the mechanisms underlying the development of resistance with long-term anlotinib treatment remain obscure. Our research found that METTL1 expression was heightened in anlotinib-resistant
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Chronic kidney disease and left ventricular diastolic dysfunction (CKD-LVDD) alter cardiac expression of mitochondria-related genes in swine Transl. Res. (IF 7.8) Pub Date : 2024-01-22 Alejandro R. Chade, Rhys Sitz, Taylor J. Kelty, Elizabeth McCarthy, Darla L. Tharp, R. Scott Rector, Alfonso Eirin
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Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged mice Transl. Res. (IF 7.8) Pub Date : 2024-01-19 Junhua Li, Hui Xu, Kun Zhang, Yafang Liu, Cong Zeng, Yanni Fu, Yujuan Li
Prolonged sevoflurane anesthesia is the primary factor contributing to the development of perioperative neurocognitive disorders (PND). Recent studies have highlighted neuronal apoptosis and abnormal dendritic structures as crucial features of PND. Astrocytes-derived exosomes (ADEs) have been identified as carriers of microRNAs (miRNAs), playing a vital role in cell-to-cell communication through transmitting
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Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury Transl. Res. (IF 7.8) Pub Date : 2024-01-19 Zhihai Huang, Yu Feng, Yulan Zhang, Xiaohui Ma, Xuemei Zong, J. Dedrick Jordan, Quanguang Zhang
Traumatic brain injury (TBI) has a significant impact on cognitive function, affecting millions of people worldwide. Myelin loss is a prominent pathological feature of TBI, while well-functioning myelin is crucial for memory and cognition. Utilizing drug repurposing to identify effective drug candidates for TBI treatment has gained attention. Notably, recent research has highlighted the potential of
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Interleukin-33/ST2 axis involvement in atrial remodeling and arrhythmogenesis Transl. Res. (IF 7.8) Pub Date : 2024-01-18 Tzu-Yu Cheng, Yao-Chang Chen, Shao-Jung Li, Fong-Jhih Lin, Yen-Yu Lu, Ting-I Lee, Ting-Wei Lee, Satoshi Higa, Yu-Hsun Kao, Yi-Jen Chen
Interleukin (IL)-33, a cytokine involved in immune responses, can activate its receptor, suppression of tumorigenicity 2 (ST2), is elevated during atrial fibrillation (AF). However, the role of IL-33/ST2 signaling in atrial arrhythmia is unclear. This study explored the pathological effects of the IL-33/ST2 axis on atrial remodeling and arrhythmogenesis. Patch clamping, confocal microscopy, and Western
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Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer Transl. Res. (IF 7.8) Pub Date : 2024-01-18 Fuqiang Huang, Na Zhao, Pei Cai, Mengjie Hou, Shuhui Yang, Bohao Zheng, Qian Ma, Jingpeng Jiang, Xiaochen Gai, Yilei Mao, Lianmei Wang, Zhongdong Hu, Xiaojun Zha, Fangming Liu, Hongbing Zhang
Due to soared obesity population worldwide, hepatosteatosis is becoming a major risk factor for hepatocellular carcinoma (HCC). Undertaken molecular events during the progression of steatosis to liver cancer are thus under intensive investigation. In this study, we demonstrated that high-fat diet potentiated mouse liver AKT2. Hepatic AKT2 hyperactivation through gain-of-function mutation of () caused
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Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation Transl. Res. (IF 7.8) Pub Date : 2024-01-08 Jiuzhou Chen, Huiyuan Qin, Jingzhe Hao, Qing Wang, Shaojie Chen, Gang Yang, Mingfang Li, Xiyu Zhu, Dongjin Wang, Hongwu Chen, Chang Cui, Minglong Chen
Atrial cardiomyopathy (ACM) forms the substrate for atrial fibrillation (AF) and underlies the potential for atrial thrombus formation and subsequent stroke. However, generating stable animal models that accurately replicate the entire progression of atrial lesions, particularly the onset of AF, presents significant challenges. In the present study, we found that the isoform of CRE-binding protein
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Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition Transl. Res. (IF 7.8) Pub Date : 2024-01-07 Min-Chun Liao, Chao-Sheng Lo, Yu-Chao Pang, Wen-Xia Yang, Ke Su, Xin-Ping Zhao, Kana N. Miyata, Junzheng Peng, Julie R. Ingelfinger, John S.D. Chan, Shao-Ling Zhang
Heterogeneous nuclear ribonucleoprotein F (HnRNP F) is a key regulator for nucleic acid metabolism; however, whether HnRNP F expression is important in maintaining podocyte integrity is unclear. Nephroseq analysis from a registry of human kidney biopsies was performed. Age- and sex-matched podocyte-specific HnRNP F knockout ( KO) mice and control () were studied. Podocytopathy was induced in male mice
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Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice Transl. Res. (IF 7.8) Pub Date : 2024-01-03 Rifeng Gao, Kun Yang, Shiguan Le, Hanchuan Chen, Xiaolei Sun, Zhen Dong, Pingjin Gao, Xilu Wang, Jiaran Shi, Yanan Qu, Xiang Wei, Kai Hu, Jiucun Wang, Li Jin, Yi Li, Junbo Ge, Aijun Sun
High-altitude heart disease (HAHD) is a complex pathophysiological condition related to systemic hypobaric hypoxia in response to transitioning to high altitude. Hypoxia can cause myocardial metabolic dysregulation, leading to an increased risk of heart failure and sudden cardiac death. Aldehyde dehydrogenase 2 () could regulate myocardial energy metabolism and plays a protective role in various cardiovascular
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Metabolomic and lipidomic landscape of porcine kidney associated with kidney perfusion in heart beating donors and donors after cardiac death Transl. Res. (IF 7.8) Pub Date : 2023-12-03 Iga Stryjak, Natalia Warmuzińska, Kamil Łuczykowski, Karol Jaroch, Peter Urbanellis, Markus Selzner, Barbara Bojko
Transplant centers are currently facing a lack of tools to ensure adequate evaluation of the quality of the available organs, as well as a significant shortage of kidney donors. Therefore, efforts are being made to facilitate the effective use of available organs and expand the donor pool, particularly with expanded criteria donors. Fulfilling a need, we aim to present an innovative analytical method
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Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs Transl. Res. (IF 7.8) Pub Date : 2023-12-01 Dian-Shi Wang, Li Ju, Arsène G. Pinguelo, Kirusanthy Kaneshwaran, Sean C. Haffey, Irene Lecker, Himaben Gohil, Michael B. Wheeler, Lilia Kaustov, Anthony Ariza, MeiFeng Yu, Allen Volchuk, Benjamin E. Steinberg, Neil M. Goldenberg, Beverley A. Orser
General anesthetic drugs cause cognitive deficits that persist after the drugs have been eliminated. Astrocytes may contribute to such cognition-impairing effects through the release of one or more paracrine factors that increase a tonic inhibitory conductance generated by extrasynaptic γ-aminobutyric acid type A (GABA) receptors in hippocampal neurons. The mechanisms underlying this astrocyte-to-neuron
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Efficacy of oral manganese and D-galactose therapy in a patient bearing a novel TMEM165 variant Transl. Res. (IF 7.8) Pub Date : 2023-11-25 Zoé Durin, Alexandre Raynor, François Fenaille, Sophie Cholet, Sandrine Vuillaumier-Barrot, Jean-Meidi Alili, Joël Poupon, Nouzha Djebrani Oussedik, Caroline Tuchmann-Durand, Jennifer Attali, Romain Touzé, Thierry Dupré, Elodie Lebredonchel, Marlyse Angah Akaffou, Dominique Legrand, Pascale de Lonlay, Arnaud Bruneel, François Foulquier
TMEM165-CDG has first been reported in 2012 and manganese supplementation was shown highly efficient in rescuing glycosylation in isogenic KO cells. The unreported homozygous missense c.928G>C; p.Ala310Pro variant leading to a functional but unstable protein was identified. This patient was diagnosed at 2 months and displays a predominant bone phenotype and combined defects in and GAG glycosylation
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Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease Transl. Res. (IF 7.8) Pub Date : 2023-11-22 Xiaowen Chen, Jing Xiao, Danping Tao, Yunyi Liang, Sijia Chen, Lingyu Shen, Shuting Li, Zerong Zheng, Yao Zeng, Congwei Luo, Fenfen Peng, Haibo Long
Podocyte damage is the major cause of glomerular injury and proteinuria in multiple chronic kidney diseases. Metadherin (MTDH) is involved in podocyte apoptosis and promotes renal tubular injury in mouse models of diabetic nephropathy and renal fibrosis; however, its role in podocyte injury and proteinuria needs further exploration. Here, we show that MTDH was induced in the glomerular podocytes of
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Knockdown of ADAM8 inhibits the proliferation, migration, invasion, and tumorigenesis of renal clear cell carcinoma cells to enhance the immunotherapy efficacy Transl. Res. (IF 7.8) Pub Date : 2023-11-20 Hongchen Qu, Minghuan Mao, Kai Wang, Zhongyi Mu, Bin Hu
The current study performed bioinformatics and and experiments to explore the effects of ADAM8 on the malignant behaviors and immunotherapeutic efficacy of renal clear cell carcinoma (ccRCC) Cells. The modular genes most associated with immune cells were screened. Then, prognostic risk models were constructed by univariate COX analysis, LASSO regression analysis and multivariate COX analysis, and their
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High Comorbidity of Pediatric Cancers in Patients with Birth Defects: Insights from Whole Genome Sequencing Analysis of Copy Number Variations Transl. Res. (IF 7.8) Pub Date : 2023-11-19 Hui-Qi Qu, Joseph T. Glessner, Jingchun Qu, Yichuan Liu, Deborah Watson, Xiao Chang, Amir Hossein Saeidian, Haijun Qiu, Frank D Mentch, John J Connolly, Hakon Hakonarson
Patients with birth defects (BD) exhibit an elevated risk of cancer. We aimed to investigate the potential link between pediatric cancers and BDs, exploring the hypothesis of shared genetic defects contributing to the coexistence of these conditions. This study included 1454 probands with BDs (704 females and 750 males), including 619 (42.3%) with and 845 (57.7%) without co-occurrence of pediatric
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Current updates on metabolites and its interlinked pathways as biomarkers for diabetic kidney disease: a systematic review Transl. Res. (IF 7.8) Pub Date : 2023-11-10 Soumik Das, Devi Rajeswari, Ganesh Venkataraman, Ramprasad Elumalai, Sivaraman Dhanasekaran, Gnanasambandan Ramanathan
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes mellitus (DM) that poses a serious risk as it can lead to end-stage renal disease (ESRD). DKD is linked to changes in the diversity, composition, and functionality of the microbiota present in the gastrointestinal tract. The interplay between the gut microbiota and the host organism is primarily facilitated by metabolites
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Tumor molecular landscape of Epstein-Barr virus (EBV) related nasopharyngeal carcinoma in EBV-endemic and non-endemic areas: implications for improving treatment modalities Transl. Res. (IF 7.8) Pub Date : 2023-11-08 Deborah Lenoci, Carlo Resteghini, Mara S. Serafini, Federico Pistore, Silvana Canevari, Brigette Ma, Stefano Cavalieri, Salvatore Alfieri, Annalisa Trama, Lisa Licitra, Loris De Cecco
Epstein-Barr virus (EBV) related- nasopharyngeal carcinoma (NPC) is a squamous carcinoma of the nasopharyngeal mucosal lining. Endemic areas (EA) are east and Southeast Asia, were NPC was recorded with higher incidence and longer estimated survival than in non-endemic area (NEA) such as Europe, We analyzed the gene expression and microenvironment properties of NPC in both areas to identify molecular
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Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease Transl. Res. (IF 7.8) Pub Date : 2023-11-04 Yiling Cao, Hua Su, Jieyu Zeng, Yaru Xie, Zezhou Liu, Feng Liu, Yang Qiu, Fan Yi, Jihong Lin, Hans-Peter Hammes, Chun Zhang
Diabetic kidney disease (DKD) is one of the leading causes to develop end-stage kidney disease worldwide. Pericytes are implicated in the development of tissue fibrosis. However, the underlying mechanisms of pericytes in DKD remain largely unknown. We isolated and cultured primary pericytes and rat mesangial cells (HBZY-1). Western blot and qRT-PCR analysis were used to explore the role and regulatory
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TRPV4 in adipose tissue ameliorates diet-induced obesity by promoting white adipocyte browning Transl. Res. (IF 7.8) Pub Date : 2023-11-04 Yan Zhang, Jie Xue, Wenjuan Zhu, Haomin Wang, Pengjiao Xi, Derun Tian
The induction of adipocyte browning to increase energy expenditure is a promising strategy to combat obesity. Transient receptor potential channel V4 (TRPV4) functions as a nonselective cation channel in various cells and plays physiological roles in osmotic and thermal sensations. However, the function of TRPV4 in energy metabolism remains controversial. This study revealed the role of TRPV4 in adipose
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Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma Transl. Res. (IF 7.8) Pub Date : 2023-10-31 Mingyang Li, Xingjian Yan, He Liu, Wenhao Miao, Wenbo Wu, Yuyang Zhao, Chungang Wang, Haitao Liu
Lynch syndrome, an autosomal dominant hereditary disease arising from mutations in mismatch repair genes, is linked to the development of multiple tumor types, notably colorectal cancer, endometrial carcinoma and upper urinary tract urothelial carcinoma. In this study, we present the case of a young patient diagnosed with upper urinary tract urothelial carcinoma, notable for a familial history of diverse
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