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Antioxidative and anti-inflammatory effects of taxifolin in H2O2-induced oxidative stress in HTR-8/SVneo trophoblast cell line Reprod. Toxicol. (IF 3.3) Pub Date : 2024-04-02 Marija Bruić, Andrea Pirković, Sunčica Borozan, Mirjana Nacka Aleksić, Milica Jovanović Krivokuća, Biljana Spremo-Potparević
Oxidative stress has been implicated in numerous pregnancy-related disorders. Biologically active plant secondary metabolites, which are present in everyday diet, could prove effective therapeutic agents in preventing these disorders. This study evaluated effects of taxifolin (dihydroquercetin) on ROS production, markers of oxidative damage to lipids and proteins, activity of antioxidant enzymes and
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Effects of superparamagnetic iron oxide nanoparticles (SPIONS) testicular injection on Leydig cell function and sperm production in a murine model Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-30 Fausto S. Ferraz, Graziela de P.F. Dantas, John L.P. Coimbra, Jorge L. López, Samyra M.S.N. Lacerda, Mara L. dos Santos, Carolina P. Vieira, Nathália de L.E.M. Lara, Pedro I.M. Viana, Luiz O. Ladeira, Leonardo O. Guarnieri, Eduardo M.A. Marçal, Márcio F.D. Moraes, Estefânia M.N. Martins, Lídia M. Andrade, Guilherme M.J. Costa
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Perspectives on chick embryo models in developmental and reproductive toxicity screening Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-30 Biswajeet Acharya, Sandip Dey, Prafulla Kumar Sahu, Amulyaratna Behera, Bimalendu Chowdhury, Suchismeeta Behera
Teratology, the study of congenital anomalies and their causative factors intersects with developmental and reproductive toxicology, employing innovative methodologies. Evaluating the potential impacts of teratogens on fetal development and assessing human risk is an essential prerequisite in preclinical research. The chicken embryo model has emerged as a powerful tool for understanding human embryonic
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Exploring the association between early-life air pollution exposure and autism spectrum disorders in children: A systematic review and meta-analysis Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-29 Teerachai Amnuaylojaroen, Nichapa Parasin, Surasak Saokaew
The objective of this meta-analysis is to investigate the association between air pollution and the vulnerability of children to autism spectrum disorders (ASD). A thorough examination and analysis of data obtained from a compilation of 14 studies was undertaken, with a particular emphasis on investigating the effects of nitrogen dioxide (NO), oxide of nitrogen (NO), ozone (O), and particulate matter
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Epigenetic modifications in the ferroptosis pathway in cord blood cells from newborns of smoking mothers and their influence on fetal growth Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-27 Eva Barrio, Diego Lerma-Puertas, José Javier Jaulín-Pueyo, José Ignacio Labarta, Ana Gascón-Catalán
Maternal smoking during pregnancy increases oxidative stress and decreases antioxidant capacity in newborns. Uncontrolled oxidative stress plays a role in fetal development disorders and in adverse perinatal outcomes. In order to identify molecular pathways involved in low fetal growth, epigenetic modifications in newborns of smoking and non-smoking mothers were examined. Low birth weight newborns
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Exposure to endocrine disrupting chemicals (bisphenols, parabens, and triclosan) and their associations with preterm birth in humans Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-24 Tina Kek, Ksenija Geršak, Irma Virant-Klun
Preterm birth in humans (PTB), defined as birth prior to 37 weeks of gestation, is one of the most important causes of neonatal morbidity and mortality and is associated with adverse health outcomes later in life. Attributed to many different etiological factors, estimated 15.1 million or 11.1% of births each year are preterm, which is more than 1 per 10 livebirths globally. Environmental pollution
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Assessing preconception exposure to environmental chemicals and fecundity: Strategies, challenges, and research priorities Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-22 Jillian Ashley-Martin, Jacob Hammond, Maria P. Velez
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Molecular insights into the antioxidative and anti-inflammatory effects of P-coumaric acid against bisphenol A-induced testicular injury: In vivo and in silico studies Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-19 Samet Tekin, Emin Sengul, Serkan Yildirim, Emrah Hicazi Aksu, İsmail Bolat, Burak Çınar, Azizeh Shadidizaji, Fikret Çelebi, Mohamad Warda
This study investigated the protective effects of p-coumaric acid (PCA) against bisphenol A (BPA)-induced testicular toxicity in male rats. The rats were divided into control, BPA, BPA+PCA50, BPA+PCA100, and PCA100 groups. Following a 14-day treatment period, various analyses were conducted on epididymal sperm quality and testicular tissues. PCA exhibited dose-dependent cytoprotective, antioxidant
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Association between polycyclic aromatic hydrocarbons and infertility in U.S. women: National Health and Nutrition Examination Survey 2013–2016 Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-16 Xiaomei Wu, Suixiang Wang, Xiaoxiao Lin, Huanzhu Liang, Yingying Wu, Yuxuan Tan, Huixian Zeng, Qian Chen, Jie Wang, Feng Huang, Ziang Guo, Puyi Xing, Jiyu Nie, Huojie Yao, Yingyin Fu, Zhiyu Yang, Zurui Zeng, Hongbiao Xu, Xingming Zhong, Chunxia Jing
Although there is a body of research indicating the potential impact of polycyclic aromatic hydrocarbons (PAHs) exposure on male infertility, the understanding of how PAH might affect female infertility is still limited. This study aimed to evaluate associations of PAHs, both individually and as a mixture, with female infertility using multiple logistic regression, Bayesian kernel machine regression
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Perspectives on folate with special reference to epigenetics and neural tube defects Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-12 Krishna Rao Gurugubelli, Vishnu Bhat Ballambattu
Folate is a micronutrient essential for DNA synthesis, cell division, fetal growth and development. Folate deficiency leads to genomic instability. Inadequate intake of folate during conception may lead to neural tube defects (NTDs) in the offspring. Folate influences the DNA methylation, histone methylation and homocysteine mediated gene methylation. DNA methylation influences the expression of microRNAs
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Apilarnil ameliorates Bisphenol A-induced testicular toxicity in adult male rats via improving antioxidant potency and PCNA expression Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-12 Mohamed H. Elashal, Aida A. Abd El-Wahed, Mostafa Abdelgaber Mohamed, Rania Hamad, Mabrouk Attia Abd Eldaim, Shaden A.M. Khalifa, Badr Aldahmash, Hesham R. El-Seedi, Bishoy El-Aarag
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Hormetic effects of a cannabinoid system component, 2-arachidonoyl glycerol, on cell viability and expression profile of growth factors in cultured mouse Sertoli cells: Friend or foe of male fertility? Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-09 Shadi Mohammadpour-Asl, Shiva Roshan-Milani, Amin Abdollahzade Fard, Ali Golchin
The generally undesired effects of exocannabinoids on male reproduction include alterations in testicular cell proliferation and function, as well as apoptosis induction. However, this paradigm has been challenged by the ability of endocannabinoids to regulate reproductive function. The present study addresses these paradoxical facts by investigating the effects of the endocannabinoid 2-arachidonoyl
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Impact of GSTT1 AND GSTM1 variants and hair mercury concentration in maternal blood pressure among coastal pregnant women in Central Java, Indonesia Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-08 Herna Rizkia Armatussolikha, Tri Indah Winarni, Nani Maharani, Julian Dewantiningrum, Muflihatul Muniroh
The and genes have a role in mercury metabolism and excretion, as well as blood pressure response, impacting birth outcomes. The present study assesses whether and deletion variants and maternal hair Hg concentration are associated with blood pressure and birth outcomes among the Indonesian coastal pregnant mother population. A cross-sectional study was conducted on 139 pregnant women in the Jepara
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Use of leflunomide among girls and women of childbearing age and occurrence of leflunomide-exposed pregnancies in Germany Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-08 Christina Princk, Bianca Kollhorst, Ulrike Haug
Leflunomide is contraindicated during pregnancy and treatment cessation is recommended two years before pregnancy. We aimed to describe leflunomide use in women of childbearing age in Germany, the occurrence of pregnancies in women using leflunomide and malformations among children possibly exposed in utero. Using the GePaRD database (claims data, ∼20% of the German population), we determined annual
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Ulipristal (UPA) effects on rat ovaries: Unraveling follicle dynamics, ovulation inhibition, and safety implications for prolonged use Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-06 Mana Hirano, Osamu Wada-Hiraike, Motoko Fukui, Seiji Shibata, Mari Uehara, Aiko Nagumo, Yoko Urata, Kenbun Sone, Miyuki Harada, Kaori Koga, Yutaka Osuga
Ulipristal (UPA), a selective progesterone receptor modulator, has both agonistic and antagonistic effects on progesterone receptors. UPA suppresses ovulation by inhibiting the luteinizing hormone (LH) surge from the pituitary gland; however, the direct effect of UPA on ovarian tissue remains poorly studied. In the present study, we examined the effects of UPA on the ovaries of rats. Rats were treated
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Low levels of nicotine and cotinine but not benzo[a]pyrene induce human trophoblast cell proliferation Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-05 I. Nicholas Olomu, Vanessa Hoang, Burra V. Madhukar
E-cigarettes use constitutes a source of thirdhand nicotine exposure. The increasing use of electronic cigarettes in homes and public places increases the risk of exposure of pregnant women to thirdhand nicotine. The effects of exposure of pregnant women to very low levels of nicotine have not been studied in humans but detrimental in experimental animals. The objective of this study is to investigate
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Prenatal caffeine consumption and neurobehavioral disorders - A systematic review Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-28 Aleksander Brandão Santana, Lídia Emmanuela Wiazowski Spelta, Joselin Valeska Martinez-Sobalvarro, Raphael Caio Tamborelli Garcia, Tiago Marques dos Reis, Larissa Helena Torres
Studies have suggested associations between gestational exposure to caffeine and adverse outcomes, however the evidence is still limited. Therefore, a systematic review was conducted to investigate the association between prenatal caffeine exposure and neurobehavioral disorders. The MEDLINE (PubMed), EMBASE, Scopus, Web of Science, and LILACS databases were searched. Observational studies involving
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Endocrine-disrupting chemicals and hormonal profiles in PCOS women: A comparative study between urban and rural environment Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-28 Jalpa Patel, Hiral Chaudhary, Sonal Panchal, Trupti Joshi, Rushikesh Joshi
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Pregnancy outcomes and birth defects in offspring following Non-steroidal anti-inflammatory drugs exposure during pregnancy: A systematic review and meta-analysis Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-27 Xiaohong Chen, Yang Yang, Lin Chen, Kejing Wang
There is a high global prevalence of NSAIDs during pregnancy. However, current evidence is largely conflicting regarding the safety of gestational NSAIDs use both for the pregnancy and offspring health. The aim of this study is to systematically review the relationship between NSAIDs use during pregnancy and the risk of adverse pregnancy outcomes and congenital abnormalities. Cohort studies and case
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Modulatory effects of quercetin on histological changes, biochemical and oxidative stress of rat placenta induced by inhalation exposure to crude oil vapor Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-21 Kaveh Khazaeel, Haifa Ali Hussein, Reza Ranjbar, Mohammad Reza Tabandeh, Jala Amir Salman Alahmed
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Adverse Effects of Avobenzone on Boar Sperm Function: Disruption of Protein Kinase A Activity and Tyrosine Phosphorylation Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-18 Woo-Jin Lee, Ju-Mi Hwang, Jae-Hwan Jo, Seung-Ik Jang, Eun-Ju Jung, Jeong-Won Bae, Jae Jung Ha, Dae-Hyun Kim, Woo-Sung Kwon
Avobenzone (AVO), an ultraviolet (UV) filter, is frequently used as an ingredient in personal cosmetics. This UV filter has been found to be easily exposed in swimming pools and beaches, and it has been detected in human urine and blood. Moreover, numerous studies have demonstrated that AVO exhibits endocrine-disrupting properties. Nevertheless, the effects of AVO on male fertility have not yet fully
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Validation of a mouse 3D gastruloid-based embryotoxicity assay in reference to the ICH S5(R3) guideline chemical exposure list Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-15 Margaret Carrell Huntsman, Courtney Kehaulani Kurashima, Yusuke Marikawa
There is growing interest in establishing alternative methods in place of conventional animal tests to assess the developmental and reproductive toxicity (DART) of chemicals. Gastruloids are 3D aggregates of pluripotent stem cells that spontaneously exhibit axial elongation morphogenesis similar to gastrulation. They have been explored as in vitro embryogenesis models for developmental and toxicological
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Effects of a TAML catalyst on mice exposed during pregnancy and lactation Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-13 Laura N. Vandenberg, Joshua P. Mogus, Gillian K. Szabo
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Antioxidant effects of α-lipoic acid against epididymal oxidative damage in adult offspring rats exposed to maternal hypothyroidism stress Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-09 P. Prathima, K. Venkaiah, M. Hanuma Reddy, Jangampalli Adi Pradeepkiran, S.B. Sainath
It is well known that the epididymis promotes post-testicular sperm maturation events. However, its malfunction during congenital hypothyroidism is relatively less understood as compared to the testis. The present study evaluated the probable effect of α-lipoic acid on epididymal oxidative stress parameters in rats exposed to antithyroid drug, carbimazole during fetal period. Time-mated pregnant rats
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Excessive fluoride induces ovarian function impairment by regulating levels of ferroptosis in fluorosis women and ovarian granulosa cells Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-09 Nan Geng, Siyuan Dong, Pengpeng Xie, Yi Zhang, Rong Shi, Chen Chen, Zhao Xu, Qun Chen
The aim of this study was to investigate the role of ferroptosis in fluorosis women and the in vitro molecular mechanisms leading to ovarian dysfunction and abnormal hormone secretion by sodium fluoride (NaF) treatment of KGN cells. Fifty women with fluorosis as Fluorosis group and fifty healthy women as Control group were included in this study. The levels of lipid peroxidation and activities of antioxidant
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Cadmium disrupts spermatogenic cell cycle via piRNA-DQ717867/p53 pathway Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-06 Jiaoyang Wei, Juan Dai, Xiaofan Shi, Ruixue Zhao, Guoqing Fu, Rui Li, Chao Xia, Ling Zhang, Ting Zhou, Huaiji Wang, Yuqin Shi
Cadmium (Cd) is a harmful environmental pollutant that disrupts public health, including respiratory, digestive, and reproductive systems. In this study, male rats were exposed to CdCl at a dose of 3 mg/kg by oral for 28 days to investigate the impact on spermatogenesis. Testis tissue samples were collected after sacrifice, and piRNA expression levels were measured using piRNA microarray and qPCR.
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Biological sex differences in hepatic response to in utero dimethylbenz(a)anthracene exposure Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-02 Imaobong Inyang, Hunter E. White, Kelsey Timme, Aileen F. Keating
Fetal hepatic dimethylbenz(a)anthracene (DMBA) biotransformation is not defined, thus, this study investigated whether the fetal liver metabolizes DMBA and differs with biological sex. KK.Cg-a/a (lean; n = 20) or KK.Cg-Ay/J (obese; n = 20) pregnant mice were exposed to corn oil (CT) or DMBA (1 mg/kg bw/day) by intraperitoneal injection (n = 10/treatment) from gestation day 7–14. Postnatal day 2 male
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Cypermethrin induces Sertoli cell apoptosis through endoplasmic reticulum-mitochondrial coupling involving IP3R1-GRP75-VDAC1 Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-29 Rui Zhang, Xu-Xu Wang, Jia-fei Xie, Ting-ting Yao, Qian-wen Guo, Qi Wang, Zhen Ding, Jin-Peng Zhang, Mei-Rong Zhang, Li-Chun Xu
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Urinary metabolite biomarkers of pregnancy complications associated with maternal exposure to particulate matter Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Sunwha Park, Minki Shim, Gain Lee, Young-Ah You, Soo Min Kim, Young Min Hur, Hyejin Ko, Mi Hye Park, Sung Hun Na, Young-Han Kim, Geum Joon Cho, Jin-Gon Bae, Soo-Jeong Lee, Sun Hwa Lee, Dong-Kyu Lee, Young Ju Kim
Particulate matter 2.5 (PM2.5) is associated with reproductive health and adverse pregnancy outcomes. However, studies evaluating biological markers of PM2.5 are lacking, and identifying biomarkers for estimating prenatal exposure to prevent pregnancy complications is essential. Therefore, we aimed to explore urine metabolites that are easy to measure as biomarkers of exposure. In this matched case-control
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A low dose of benzo(a)pyrene during prepuberty in male rats generated immediate oxidative stress in the testes and compromised steroidogenic enzymes/proteins Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-24 Bárbara Campos Jorge, Ana Carolina Casali Reis, Julia Stein, Beatriz Rizzo Paschoalini, Jéssica Nogueira Bueno, Suyane da Silva Moreira, Alana Rezende Godoi, Vanessa Caroline Fioravante, Francisco Eduardo Martinez, Patrícia Fernanda Felipe Pinheiro, Arielle Cristina Arena
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Investigating the effects of valproic acid on placental epigenetic modifications and development in the CD-1 mouse model Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-26 Brianna L. Jackson, Sidra Shafique, Bryony V. Natale, David R.C. Natale, Louise M. Winn
Gestational exposure to the anticonvulsant drug valproic acid (VPA) is associated with congenital malformations and neurodevelopmental disorders through its action as a histone deacetylase inhibitor. VPA can elicit placental toxicity and affect placental growth and development. The objective of this study was to evaluate the impact of maternal exposure to VPA on the mouse placenta following exposure
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Editorial – Special issue on Developmental Origins of Health and Disease (DOHaD): Early developmental toxicology and reproductive effects Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-22 Wellerson Rodrigo Scarano, Sebastião Taboga, Jodi A. Flaws
Abstract not available
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Independent and interaction effects of prenatal exposure to high AQI and extreme Humidex on the risk of preterm birth: A large sample population study in northern China Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-20 Jiatao Zhang, Yu Tao, Yongchao Wang, Xiaokang Ji, Yanling Wu, Fengmei Zhang, Zhiping Wang
The combined effects of air pollution and extreme temperature on PTB remain unclear. To evaluate the independent effect and interaction effect of prenatal extreme exposure to air quality index (AQI) and Humidex, on PTB. Based on the National Health Care Data Platform of Shandong University, women who gave birth in 2019–2020 were selected for the study. First, the independent effects of AQI and Humidex
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Maternal oral exposure to low-dose BPA accelerates the onset of puberty by promoting prepubertal Kiss1 expression in the AVPV nucleus of female offspring Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-15 Chenyan Jiang, Wenke Dong, Guanglin Gao, Wen Sun, Yonghong Wang, Bowen Zhan, Yanyan Sun, Jian Yu
As the incidence of precocious puberty has risen in recent years and the age at puberty onset is younger, children may be at increased risk for health consequences associated with the early onset of puberty. Bisphenol A (BPA) is recognized as an endocrine disruptor chemical that is reported to induce precocious puberty. The effect of BPA exposure modes, times, and doses (especially low dose) were controversial
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Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-19 Ju-Mi Hwang, Jeong-Won Bae, Woo-Jin Lee, Woo-Sung Kwon
4-Nonylphenol (4-NP) is an endocrine-disrupting chemical that impairs animal and human reproduction. However, the mechanisms underlying male reproductive dysfunction by 4-NP have not been fully understood. Herein, we demonstrated the effects of 4-NP on boar sperm functions and molecular mechanisms. Spermatozoa were treated with various concentrations of 4-NP (0, 10, 25, 50, 75, and 100 μM) during capacitation
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Melatonin-mediated actions and circadian functions that improve implantation, fetal health and pregnancy outcome Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-06 Russel J. Reiter, Ramaswamy Sharma, Luiz Gustavo DA Chuffa, Debora APEC Zuccari, Fernanda G. Amaral, Jose Cipolla-Neto
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Protective role of hesperidin in finasteride-induced testicular toxicity in adult male Wistar rats: Insights into oxidative stress, apoptosis, and ultrastructure of seminiferous tubules Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-10 Iman Nabil, Amira Abulfotooh Eid, Hend A. Yassin, Rana Ahmed Abouelrous, Amany A. Solaiman
A negative impact of finasteride on fertility has been reported, in which over production of reactive oxygen species and apoptosis were implicated. Hesperidin, a plant-derived bioflavonoid with antioxidant and anti-apoptotic effects, may mitigate these adverse effects. In order to investigate the possible protective role of hesperidin against finasteride-induced seminiferous tubules toxicity in adult
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Effect of prenatal exposure to phthalates on birth weight of offspring: A meta-analysis Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-03 Liya Pang, Danrong Chen, Hongcheng Wei, Linchen Lan, Jinhui Li, Qiaoqiao Xu, Huijun Li, Chuncheng Lu, Qiuqin Tang, Weiyue Hu, Wei Wu
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Unravelling the epigenetic impact: Oxidative stress and its role in male infertility-associated sperm dysfunction Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-02 Gokul Sudhakaran, D. Kesavan, Karthikeyan Kandaswamy, Ajay Guru, Jesu Arockiaraj
Male infertility is a multifactorial condition influenced by epigenetic regulation, oxidative stress, and mitochondrial dysfunction. Oxidative stress-induced damage leads to epigenetic modifications, disrupting gene expression crucial for spermatogenesis and fertilization. Paternal exposure to oxidative stress induces transgenerational epigenetic alterations, potentially impacting male fertility in
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In vivo exposure to electronic waste (e-waste) leachate and hydraulic fracturing fluid adversely impacts the male reproductive system Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-30 Amna Raja, Patricia Costa, Jason L. Blum, Shannon Doherty-Lyons, Juliet K. Igbo, Gabriella Meltzer, William Orem, Michael McCawley, Judith T. Zelikoff
Human health effects can arise from unregulated manual disassembly of electronic waste (e-waste) and/or hydraulic fracturing fluid spills. There is limited literature on the effects of e-waste and hydraulic fracturing wastewater exposure on the male reproductive system. Thus, this proof-of-concept study begins to address the question of how wastewater from two potentially hazardous environmental processes
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Naproxen administration affects murine late folliculogenesis, reduces granulosa cell proliferation and the number of ovulated oocytes Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-29 Bernardo Camara Nascimento, Camila Stefane Ferreira, Stella Pollyanne Oliveira, Luiza Aparecida Ansaloni Chagas Pereira, Guilherme Antonio Lopes, Júlia Meireles Nogueira, Rayan Silva Paula, Erika Cristina Jorge, Paulo Henrique Almeida Campos-Junior
Naproxen reduces the production of prostaglandins via inhibition of the cyclooxygenase. Studies have shown that its administration in women can be related to failed ovulation. Therefore, preclinical investigations must be performed in order to investigate its effects in experimental models. Thus, the aim of this study was to evaluate the effects of naproxen on murine folliculogenesis, ovulation, and
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Increased NAD+ levels protect female mouse reproductive system against zearalenone-impaired glycolysis, lipid metabolism, antioxidant capacity and inflammation Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-29 Chao Dai, Mengqian Hou, Xudong Yang, Zhefeng Wang, Changpo Sun, Xin Wu, Shujin Wang
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Mediation of association between semen microcystin exposure and semen quality by sex hormones in Chinese men Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-28 Yang Luo, Dihui Xu, Yuhan Ma, Wen Yu, Yabing Chen, Xiaodong Han
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Perfluorooctanoic acid suppresses sperm functions via abnormal Protein Kinase B activation during capacitation Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-23 Seung-Ik Jang, Jae-Hwan Jo, Eun-Ju Jung, Woo-Jin Lee, Ju-Mi Hwang, Jeong-Won Bae, Sangsu Shin, Sang In Lee, Myoung Ok Kim, Woo-Sung Kwon
Perfluorooctanoic acid (PFOA) is a perfluorinated compound, a synthesized chemical, and has been used in several industrial products for more than 70 years. Although PFOA is known to exert toxic effects in normal cells, there is no detailed information on its reproductive toxicity and its effects on sperm functions related to protein kinase B (AKT). Therefore, this study was conducted to explore the
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Repeat-dose and embryo-fetal developmental toxicity of zinpentraxin alfa Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-22 Gautham K. Rao, Sara F. Santagostino, Lisa Wong, Ayumi Inoue, Audrey Arjomandi, Rajbharan Yadav, Wendy G. Halpern
Zinpentraxin alfa is a recombinant human pentraxin-2 (PTX-2) developed for the treatment of various fibrotic diseases with the hypothesis that supplementing endogenous PTX-2 levels through intravenous administration should increase its regulatory capacity in circulation and at the site of disease, thereby promoting healing and reducing fibrosis. Zinpentraxin alfa has been studied in various clinical
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SP-Max-A herbomineral formulation attenuates busulfan-induced oligospermia in mice by preventing loss of reproductive hormones Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-18 Ankit P. Laddha, Shantanu Joshi, Yogesh A. Kulkarni
SP-Max herbal capsule formulation contains Withania somnifera, Asparagus recemosus, Mucuna pruriens, Chlorophytum arundinaceum, Ipomoea digitata, and Dioscorea bulbifera which are reported in the ‘Ayurveda’, an Indian Traditional System of medicine as aphrodisiacs. The present study focused on the effect of herbomineral formulation, SP-Max in the treatment of oligospermia. Oligospermia was induced
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Cobalt's role in modulating antioxidant systems and semen quality in males Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-15 Michał Tiszler, Katarzyna Olszak-Wąsik, Anna Machoń-Grecka, Francesco Bellanti, Michał Dobrakowski, Sławomir Kasperczyk, Anita Olejek, Aleksandra Kasperczyk
The present study investigated associations between environmental exposure to cobalt (Co) and the levels of oxidative stress parameters and the antioxidant defense system in the seminal plasma of fertile males. The study population consisted of 117 healthy, non-smoking, fertile men from the southern region of Poland. The study was carried out in 2021–22. Based on the median cobalt levels in seminal
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Long-term maintenance of human endometrial epithelial organoids and their stem cell properties Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-12 Yanan Zhang, Wei Chen, Xiaomin Dong, Wei Shang, Suxia Shao, Lei Zhang
The endometrium undergoes dynamic changes throughout the menstrual cycle and pregnancy, which is unique to primates. Endometrium remodeling is essential for the implantation and nutritional support of the conceptus. Despite this, the role of uterine glands in driving endometrial tissue remodeling is still poorly understood. To address this, a 3-dimensional culture system was used to generate endometrial
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Evaluation of a microphysiological human placental barrier model for studying placental drug transfer Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-12 Shekh Rahman, Brian Kwee, Miao Li, Mani Chidambaram, Xiaobo He, Matthew Bryant, Darshan Mehta, Noriko Nakamura, Bounleut Phanavanh, Jeffery Fisher, Kyung Sung
Understanding drug transport across the placental barrier is important for assessing the potential fetal drug toxicity and birth defect risks. Current in vivo and in vitro models have structural and functional limitations in evaluating placental drug transfer and toxicity. Microphysiological systems (MPSs) offer more accurate and relevant physiological models of human tissues and organs on a miniature
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Decamethylcyclopentasiloxane developmental neurotoxicity testing Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-05 Anthony R. Scialli
Abstract not available
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Reproductive Toxicology: Special Edition of the 51st European Teratology Society (ETS) Meeting 2023 Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-04
Abstract not available
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Reproductive Toxicology: Special Edition of the 50th European Teratology Society (ETS) Meeting 2022 Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-04
Abstract not available
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Cantharidin-induced toxic injury, oxidative stress, and autophagy attenuated by Astragalus polysaccharides in mouse testis Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-05 Yuanyuan Xiao, Ruxia Liu, Wenchao Tang, Changfu Yang
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Caffeine intake during pregnancy and adverse outcomes: An integrative review Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-01 Ricardo Rohweder, Thanyse de Oliveira Schmalfuss, Diessy dos Santos Borniger, Carolina Zanfir Ferreira, Marcos Kobren Zanardini, Guilherme Paulon Torrano Ferreira Lopes, Camila Pocharski Barbosa, Taiane Dornelles Moreira, Lavinia Schuler-Faccini, Maria Teresa Vieira Sanseverino, André Anjos da Silva, Alberto Mantovani Abeche, Fernanda Sales Luiz Vianna, Lucas Rosa Fraga
Caffeine intake during pregnancy is common. Caffeine crosses the placenta, raising concerns about its possible deleterious effects on the developing embryo/fetus. Studies on this subject show conflicting results, and still there is no consensus on the recommended dose of caffeine during pregnancy. We performed an integrative review with studies from six databases, using broad MESH terms to allow the
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Establishment of a 3D multicellular placental microtissues for investigating the effect of antidepressant vortioxetine Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-01 Selen Öztürk, Merve Demir, E. Arzu Koçkaya, Cagatay Karaaslan, Aysun Kılıç Süloğlu
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Adverse effects of exposure to petrol-generator exhaust fumes on the reproductive hormones, testis and spermatozoa in male dogs Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-30 C.F. Oguejiofor, U.U. Eze, I.G. Eke, A.A. Eze, O.B. Onyejekwe, B.M. Anene
There is evidence that sperm count has progressively declined in men over the recent decades. Exposure to air pollutants including petrol and diesel exhaust have been reported to impair male reproduction although there is little experimental evidence. This study investigated the effects of petrol-generator exhaust fumes (PGEF) on semen, sperm, gonadal structure and hormonal status in the dog. Sixteen
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Effects of perinatal exposures to a TAML catalyst on the mammary gland and hormone-sensitive outcomes in male mice Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-30 Gillian K. Szabo, Joshua P. Mogus, Laura N. Vandenberg
Estrogenic chemicals are common pollutants in wastewater and current effluent treatment processes are not typically effective in removing these compounds. Tetra-amido macrocyclic ligands (TAMLs) are catalysts that mimic endogenous peroxidases that may provide a solution to remove environmental pollutants including low concentrations of estrogenic compounds. Yet relatively little is known about the
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Validation of a zebrafish developmental defects assay as a qualified alternative test for its regulatory use following the ICH S5(R3) guideline Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-26 A.M.J. Weiner, I. Irijalba, M.P. Gallego, I. Ibarburu, L. Sainz, F. Goñi-de-Cerio, C. Quevedo, A. Muriana
Zebrafish is a popular toxicology model and provides an ethically acceptable small-scale analysis system with the complexity of a complete organism. Our goal is to further validate this model for its regulatory use for reproductive and developmental defects by testing the compounds indicated in the “Guideline on detection of reproductive and developmental toxicity for human pharmaceuticals” (ICH S5(R3)
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Emerging pollutants in etiology and pathophysiology of polycystic ovary syndrome Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-23 Rohit Gautam, Ajith Manayil Prambil, Arbind Kumar Patel, Taruna Arora