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Dynamics of cellular plasticity in non-alcoholic steatohepatitis (NASH) BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-28 Sangam Rajak
Non-alcoholic steatohepatitis (NASH) is a pathogenic stage of the broader non-alcoholic fatty liver disease (NAFLD). Histological presentation of NASH includes hepatocyte ballooning, macrophage polarization, ductular reaction, and hepatic stellate cell (HSCs) activation. At a cellular level, a heterogenous population of cells such as hepatocytes, macrophages, cholangiocytes, and HSCs undergo dramatic
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Biotherapeutic approaches against cardio-metabolic dysfunctions based on extracellular vesicles BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-28 Stéphane Marchal, Ramaroson Andriantsitohaina, M. Carmen Martinez
Among the different pathways involved in the cell-to-cell communication, extracellular vesicles (EVs) are defined as key players in the transport of different signalling molecules, such as lipids, proteins, and RNA, from the originating cells to specific target cells. The biogenesis and composition of EVs are complex and confer them a unique ability to more effectively reach tissues and cells as compared
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Exploring the ferroptosis-related gene lipocalin 2 as a potential biomarker for sepsis-induced acute respiratory distress syndrome based on machine learning BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-27 Jiayi Zhan, Junming Chen, Liyan Deng, Yining Lu, Lianxiang Luo
Sepsis is a major cause of mortality in patients, and ARDS is one of the most common outcomes. The pathophysiology of acute respiratory distress syndrome (ARDS) caused by sepsis is significantly impacted by genes related to ferroptosis. In this study, Weighted gene co-expression network analysis (WGCNA), protein-protein interaction (PPI) networks, functional enrichment analysis, and machine learning
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Uterine leiomyosarcoma cell-derived extracellular vesicles induce the formation of cancer-associated fibroblasts BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-27 Yukari Nagao, Akira Yokoi, Kosuke Yoshida, Masami Kitagawa, Eri Asano-Inami, Tomoyasu Kato, Mitsuya Ishikawa, Yusuke Yamamoto, Hiroaki Kajiyama
Uterine leiomyosarcoma (ULMS) is a rare malignant tumor, which is aggressive, and has a poor prognosis even during its early stages. Extracellular vesicles (EVs) carry cargo, such as microRNAs (miRNAs), which are involved in intercellular communication in the tumor microenvironment and other processes. Because there are no studies on EV-related miRNAs in ULMS, we identified EV-related miRNAs in ULMS
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The intricate dance of tumor evolution: Exploring immune escape, tumor migration, drug resistance, and treatment strategies BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-25 Xiaojun Guo, Xiaonan Bian, Yitong Li, Xiao Zhu, Xiaorong Zhou
Recent research has unveiled fascinating insights into the intricate mechanisms governing tumor evolution. These studies have illuminated how tumors adapt and proliferate by exploiting various factors, including immune evasion, resistance to therapeutic drugs, genetic mutations, and their ability to adapt to different environments. Furthermore, investigations into tumor heterogeneity and chromosomal
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Cholestatic liver disease leads to significant adaptative changes in neural circuits regulating social behavior in mice to enhance sociability BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-25 Wagdi Almishri, Mohammed O. Altonsy, Mark G. Swain
Cholestatic liver diseases (CLD) are commonly associated with behavioral changes, including social isolation, that negatively affects patient quality of life and remains unaltered by current therapies. It remains unclear whether CLD-associated social dysfunction stems from a direct effect on the brain, or from the psychological impact of CLD. The psychological component of disease is absent in animals
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Zika virus infection impairs synaptogenesis, induces neuroinflammation, and could be an environmental risk factor for autism spectrum disorder outcome BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-24 Cristine Marie Yde Ohki, Cecília Benazzato, Vanessa van der Linden, Julia V. França, Carmen M. Toledo, Rafael Rahal Guaragna Machado, Danielle Bastos Araujo, Danielle Bruna Leal Oliveira, Romulo S. Neris, Iranaia Assunção-Miranda, Isis Nem de Oliveira Souza, Clara O. Nogueira, Paulo Emilio Corrêa Leite, Hélio van der Linden, Claudia P. Figueiredo, Edison Luiz Durigon, Julia R. Clarke, Fabiele Baldino
Zika virus (ZIKV) infection was first associated with Central Nervous System (CNS) infections in Brazil in 2015, correlated with an increased number of newborns with microcephaly, which ended up characterizing the Congenital Zika Syndrome (CZS). Here, we investigated the impact of ZIKV infection on the functionality of iPSC-derived astrocytes. Besides, we extrapolated our findings to a Brazilian cohort
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The contribution and therapeutic implications of IGHMBP2 mutations on IGHMBP2 biochemical activity and ABT1 association BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-24 Gangadhar P. Vadla, Kamal Singh, Christian L. Lorson, Monique A. Lorson
Mutations within immunoglobulin mu DNA binding protein (), an RNA-DNA helicase, result in SMA with respiratory distress type I (SMARD1) and Charcot Marie Tooth type 2S (CMT2S). The underlying biochemical mechanism of IGHMBP2 is unknown as well as the functional significance of mutations in disease severity. Here we report the biochemical mechanisms of IGHMBP2 disease-causing mutations D565N and H924Y
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Pyrazole derivative Z10 ameliorates acute pancreatitis by inhibiting the ERK/Ddt pathway BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-22 Wenying Zeng, Jian Pan, Wanlian Li, Borong Huang, Xing Lu, Juan Xiao
Acute pancreatitis (AP) can lead to death; however, there is no specific treatment for AP. Screening of drugs for AP treatment is rarely performed. Compounds were screened in a primary pancreatic acinar cell and peritoneal macrophage coculture system. Compounds were used in vitro and in vivo. Compound targets were predicted and validated. Among the 18 nitrogen-containing heterocycles, Z10 was shown
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PADI4 negatively regulates RIG-I-mediated antiviral response through deacetylation of IFN-β promoter via HDAC1 BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-20 Qingwen Feng, Qingwei Guo, Weijie Yu, Peng Li, Chengfang Yao, Lin Wang, Guanhua Song
The production of type I interferon (IFN) is precisely modulated by host to protect against viral infection efficiently without obvious immune disorders. Elucidating the tight control towards type I IFN production would be helpful to get insight into natural immunity and inflammatory diseases. As yet, however, the mechanisms that regulate IFN-β production, especially the epigenetic regulatory mechanisms
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GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-19 Meitian Wang, Xiuqing He, Jie Li, Daobin Han, Pan You, Hui Yu, Luwen Wang, Bo Su
Accumulation of insoluble deposits of amyloid β-peptide (Aβ), derived from amyloid precursor protein (APP) processing, represents one of the major pathological hallmarks of Alzheimer's disease (AD). Perturbations in APP transport and hydrolysis could lead to increased Aβ production. However, the precise mechanisms underlying APP transport remain elusive. The GDP dissociation inhibitor2 (GDI2), a crucial
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Accumulation of neutral lipids in dystrophic neurites surrounding amyloid plaques in Alzheimer's disease BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-18 Hao Huang, Md Golam Sharoar, Joseph Pathoulas, Liangliang Fan, Wanxia He, Rong Xiang, Riqiang Yan
Alzheimer's disease (AD) is characterized by the formation β-amyloid (Aβ) deposited neuritic plaques. Recent evidence suggests that abnormal lipid metabolism and accumulation could serve as biomarkers for neurodegenerative diseases, including AD. Tubular endoplasmic reticulum protein, reticulon 3 (RTN3), plays a crucial role in the development of neuritic plaque and lipid metabolism in AD brains. In
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Oleic and linoleic acids promote chondrocyte apoptosis by inhibiting autophagy via downregulation of SIRT1/FOXO1 signaling BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-18 Xiaodong Li, Chen Zhao, Chuanyuan Mao, Guantong Sun, Fei Yang, Lei Wang, Xiaoqing Wang
Osteoarthritis (OA) is a complex joint disease that currently has no cure. OA involves metabolic disorders in chondrocytes and an imbalance between autophagy and apoptosis. As a common risk factor for OA, obesity induces changes in the fatty acid composition of synovial fluid, thereby disturbing chondrocyte homeostasis. However, whether unsaturated fatty acids affect the development of OA by regulating
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TIMP3/Wnt axis regulates gliosis of Müller glia BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-17 Jia-Horung Hung, Ping-Hsing Tsai, Wilson Jr F. Aala, Chao-Chung Chen, Shih-Hwa Chiou, Tak-Wah Wong, Kuen-Jer Tsai, Sheng-Min Hsu, Li-Wha Wu
Previous studies have confirmed the expression of tissue inhibitor of metalloproteinase-3 (TIMP3) in Müller glia (MG). However, the role of TIMP3 in MG remains unknown. A mouse model of laser-induced retinal damage and gliosis was generated using wild-type C57BL/6 mice. TIMP3 and associated proteins were detected using Western blotting and immunofluorescence microscopy. RNA sequencing (GSE132140) of
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HIV and gp120-induced lipid droplets loss in hepatic stellate cells contribute to profibrotic profile BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-17 Cinthya Alicia Marcela López, Rosa Nicole Freiberger, Franco Agustín Sviercz, Patricio Jarmoluk, Cintia Cevallos, Jorge Quarleri, María Victoria Delpino
Liver fibrosis is the excessive accumulation of extracellular matrix proteins, primarily collagen, in response to liver injury caused by chronic liver diseases. HIV infection accelerates the progression of liver fibrosis in patients co-infected with HCV or HBV compared to those who are only mono-infected. The early event in the progression of liver fibrosis involves the activation of hepatic stellate
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The intestinal microbial metabolite acetyl l-carnitine improves gut inflammation and immune homeostasis via CADM2 BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-16 Kai Lin, Weiyang Zheng, Mingyue Guo, Runing Zhou, Mengmeng Zhang, Tingting Liu
Intestinal symbiotic bacteria play a key role in the regulation of immune tolerance in inflammatory bowel disease (IBD) hosts. However, the bacterial strains directly involved in this regulation and their related metabolites are largely unknown. We sought to investigate the effects of intestinal microbial metabolites on intestinal epithelium and to elucidate their therapeutic potential in regulating
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Imp7 siRNA nanoparticles protect against mechanical ventilation-associated liver injury by inhibiting HMGB1 production and NETs formation BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-16 Ning Ding, Hui Xiao, Lixiao Zhen, Huiqing Li, Zengzhen Zhang, Junke Ge
Mechanical ventilation (MV) has the potential to induce extra-pulmonary organ damage by adversely affecting the lungs and promoting the secretion of inflammatory cytokines. High-mobility group box 1 protein (HMGB1) is a pro-inflammatory mediator in ventilator-induced lung injury (VILI), but its effect on MV-associated liver injury and the mechanisms are poorly understood. In the present study, mice
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Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-16 Pallavi Asthana, Hoi Leong Xavier Wong
Obesity is one of the predominant risk factors for type 2 diabetes. Despite all the modern advances in medicine, an effective drug treatment for obesity without overt side effects has not yet been found. The discovery of growth and differentiation factor 15 (GDF15), an appetite-regulating hormone, created hopes for the treatment of obesity. However, an insufficient understanding of the physiological
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Lilrb4 ameliorates ileal injury in rats with hemorrhagic shock and suppresses the activation of NF-κB signaling pathway BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-15 Hongdou Jin, Zhirong Huan, Yifeng Wu, Hao Yao, Leyao Zhang, Xin Ge
Hemorrhagic shock (HS) leads to intestinal damage and subsequent multiple organ dysfunction syndrome. Intestinal barrier dysfunction is the main cause of multiple organ failure associated with HS. Leukocyte immunoglobulin-like receptor B4 (Lilrb4) belongs to the Ig superfamily and is a vital natural immunomodulatory receptor. The purpose of this study was to identify the role and molecular mechanism
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Leishmania amazonensis infection regulates oxidate stress in hyperglycemia and diabetes impairing macrophage's function and immune response BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-15 Taylon Felipe Silva, Mariana Barbosa Detoni, Virgínia Márcia Concato-Lopes, Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, Bruna Taciane da Silva Bortoleti, Manoela Daiele Gonçalves, Ana Carolina Jacob Rodrigues, Raquel Arruda Sanfelice, Ellen Mayara Souza Cruz, Maria Stacy dos Santos Silva, Amanda Cristina Machado Carloto, Danielle Lazarin Bidoia, Idessania Nazareth Costa, Wander Rogério
Leishmaniasis is a group of infectious diseases caused by protozoa of the genus and its immunopathogenesis results from an unbalanced immune response during the infection. Diabetes is a chronic disease resulting from dysfunction of the body's production of insulin or the ability to use it properly, leading to hyperglycemia causing tissue damage and impairing the immune system. The objective of this
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Star-PAP controls oncogene expression through primary miRNA 3′-end formation to regulate cellular proliferation and tumour formation BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-15 Neeraja K. Mohanan, Feba Shaji, A.P. Sudheesh, B.P. Arathi, Nagalingam R. Sundaresan, Rakesh S. Laishram
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Spermidine ameliorates osteoarthritis via altering macrophage polarization BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-15 Qianhua Ou, Su'an Tang, Jianwei Zhu, Song Xue, Hong Huang, Yang Zhao, Yu Cai, Cuixi Wu, Jianmao Chen, Guangfeng Ruan, Changhai Ding
Spermidine (SPD) is an anti-aging natural substance, and it exerts effects through anti-apoptosis and anti-inflammation. However, the specific protective mechanism of SPD in osteoarthritis (OA) remains unclear. Here, we explored the role of SPD on the articular cartilage and the synovial tissue, and tested whether the drug would regulate the polarization of synovial macrophages by and experiments.
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House dust mite allergens induce Ca2+ signalling and alarmin responses in asthma airway epithelial cells BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-15 Xuan Ouyang, James A. Reihill, Lisa E.J. Douglas, Orla M. Dunne, Gerard P. Sergeant, S. Lorraine Martin
Type 2 inflammation in asthma develops with exposure to stimuli to include inhaled allergens from house dust mites (HDM). Features include mucus hypersecretion and the formation of pro-secretory ion transport characterised by elevated basal Cl current. Studies using human sinonasal epithelial cells treated with HDM extract report a higher protease activated receptor-2 (PAR-2) agonist-induced calcium
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Intestinal metabolite UroB alleviates cerebral ischemia/reperfusion injury by promoting competition between TRIM65 and TXNIP for binding to NLRP3 inflammasome in response to neuroinflammation BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-13 Jing Luo, Yujia Luo, Jialei Chen, Yu Gao, Junyi Tan, Yongkang Yang, Changhong Yang, Ning Jiang, Yong Luo
Our previous research suggests that targeting NLRP3 inflammasomes holds promise for mitigating cerebral ischemia/reperfusion injury. The gut metabolite Urolithin B (UroB) has been shown to inhibit the neuroinflammation. However, the specific role of UroB in cerebral ischemia/reperfusion injury and its potential impact on NLRP3 inflammasome remain unclear.
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GRIM19 deficiency aggravates metabolic disorder and ovarian dysfunction in PCOS BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-13 Lin Yang, Yang Yang, Xiaojuan Han, Chengzi Huang, Ying Wang, Danni Jiang, Lan Chao
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. Retinoid-interferon-induced mortality 19 (GRIM19) is a functional component of mitochondrial complex I that plays a role in cellular energy metabolism. However, the role of GRIM19 in the pathogenesis of PCOS is still unclear. To investigate the role of GRIM19 in the pathogenesis of PCOS. We first measured the expression
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Dysfunction of CCT3-associated network signals for the critical state during progression of hepatocellular carcinoma BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-13 Jianwei Wang, Xiaowen Guan, Ning Shang, Di Wu, Zihan Liu, Zhenzhen Guan, Zhizi Zhang, Zhongzhen Jin, Xiaoyi Wei, Xiaoran Liu, Mingzhu Song, Weijun Zhu, Guifu Dai
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and is a serious threat to human health; thus, early diagnosis and adequate treatment are essential. However, there are still great challenges in identifying the tipping point and detecting early warning signals of early HCC. In this study, we aimed to identify the tipping point (critical state) of and key molecules involved
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Fructose overconsumption accelerates renal dysfunction with aberrant glomerular endothelial-mesangial cell interactions in db/db mice BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-13 Hiroaki Tsuruta, Mako Yasuda-Yamahara, Mamoru Yoshibayashi, Shogo Kuwagata, Kosuke Yamahara, Yuki Tanaka-Sasaki, Masami Chin-Kanasaki, Shoma Matsumoto, Masatsugu Ema, Shinji Kume
For the advancement of DKD treatment, identifying unrecognized residual risk factors is essential. We explored the impact of obesity diversity derived from different carbohydrate qualities, with an emphasis on the increasing trend of excessive fructose consumption and its effect on DKD progression. In this study, we utilized mice to establish a novel diabetic model characterized by fructose overconsumption
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GLP-1 receptor agonist attenuates tubular cell ferroptosis in diabetes via enhancing AMPK-fatty acid metabolism pathway through macropinocytosis BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-12 Rui Shen, Songyan Qin, Yunhui Lv, Dandan Liu, Qingqing Ke, Caifeng Shi, Lei Jiang, Junwei Yang, Yang Zhou
Kidney tubules are mostly responsible for pathogenesis of diabetic kidney disease. Actively reabsorption of iron, high rate of lipid metabolism and exposure to concentrated redox-active compounds constructed the three main pillars of ferroptosis in tubular cells. However, limited evidence has indicated that ferroptosis is indispensable for diabetic tubular injury. Glucagon-like peptide-1 receptor agonist
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LRRC8A as a central mediator promotes colon cancer metastasis by regulating PIP5K1B/PIP2 pathway BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-11 Haifeng Zhang, Rong Liu, Zhenghui Jing, Chunying Li, Wentao Fan, Houli Li, Hongbing Li, Jie Ren, Shiyu Cui, Wenbao Zhao, Lei Yu, Yuhui Bai, Shujing Liu, Chunlu Fang, Wenqi Yang, Yuan Wei, Liangming Li, Shuang Peng
Colorectal cancer (CRC) has been the third most common malignancy and the second cause of cancer-related mortality. As the core of volume-sensitive chloride currents, leucine-rich repeat-containing 8A (LRRC8A) contributes to tumor progression but is not consistent, especially for whom the roles in colon carcinoma metastasis were not fully elucidated. Herein, LRRC8A proteins were found highly expressed
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Metabolic phenotyping and global functional analysis facilitate metabolic signature discovery for tuberculosis treatment monitoring BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-10 Nguyen Ky Anh, Nguyen Thi Hai Yen, Nguyen Tran Nam Tien, Nguyen Ky Phat, Young Jin Park, Ho-Sook Kim, Dinh Hoa Vu, Jee Youn Oh, Dong Hyun Kim, Nguyen Phuoc Long
Tracking alterations in polar metabolite and lipid levels during anti-tuberculosis (TB) interventions is an emerging biomarker discovery and validation approach due to its sensitivity in capturing changes and reflecting on the host status. Here, we employed deep plasma metabolic phenotyping to explore the TB patient metabolome during three phases of treatment: at baseline, during intensive phase treatment
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YAP/Aurora A-mediated ciliogenesis regulates ionizing radiation-induced senescence via Hedgehog pathway in tumor cells BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-10 Wei Ma, Li Wei, Liangliang Jin, Qinglong Ma, Tongshan Zhang, Yanfei Zhao, Junrui Hua, Yanan Zhang, Wenjun Wei, Nan Ding, Jufang Wang, Jinpeng He
Primary cilia are antenna-like organelles that play critical roles in sensing and responding to various signals. Nevertheless, the function of primary cilia in cellular response to ionizing radiation (IR) in tumor cells remains unclear. Here, we show that primary cilia are frequently expressed in tumor cells and tissues. Notably, IR promotes cilia formation and elongation in time- and dose-dependent
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Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-09 Zimin Fang, Jibo Han, Liming Lin, Bozhi Ye, Xuefeng Qu, Yu Zhang, Ying Zhao, Diyun Xu, Wante Lin, Sirui Shen, Julian Min, Gaojun Wu, Zhouqing Huang, Guang Liang
Cardiac hypertrophy is a crucial pathological characteristic of hypertensive heart disease and subsequent heart failure. Deubiquitinating enzymes (DUBs) have been found to be involved in the regulation of myocardial hypertrophy. OTU Domain-Containing Protein 6a (OTUD6a) is a recently identified DUB. To date, the potential role of OTUD6a in myocardial hypertrophy has not yet been revealed. We examined
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Transcription factor EB modulates the homeostasis of reactive oxygen species in intestinal epithelial cells to alleviate inflammatory bowel disease BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-09 Tianci Zhang, Roufei Zhang, Wei Liu, Yucheng Qi, Hongyi Wang, Hu Zhang, Zhixiong Xiao, Stephen J. Pandol, Yuan-Ping Han, Xiaofeng Zheng
Transcription factor EB (TFEB), a master lysosomal biogenesis and autophagy regulator, is crucial for cellular homeostasis, and its abnormality is related to diverse inflammatory diseases. Genetic variations in autophagic genes are associated with susceptibility to inflammatory bowel disease (IBD); however, little is known about the role and mechanism of TFEB in disease pathogenesis. In this study
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Ano1 regulates embryo transport by modulating intracellular calcium levels in oviduct smooth muscle BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-07 Xiao-Man Liu, Juan Li, Defang Chen, Hao Li, Xiao-Yan Qin, Yun-Xia Wang, Yong-Zhong Gu, Na Li, Li-Guang Zhou, Mei Feng
Oviductal smooth muscle exhibits spontaneous rhythmic contraction (SRC) and controls the passage of the ova at the exact time, but its mechanistic regulation remains to be determined. In this study, female mice with Ano1 (smooth muscle-specific deletion of Ano1) had reduced fertility. Deficiency of Ano1 in mice resulted in impaired oviductal SRC function and reduced calcium signaling in individual
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Sex-specific regulation of miR-22 and ERα in white adipose tissue of obese dam's female offspring impairs the early postnatal development of functional beige adipocytes in mice BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-07 Érica de Sousa, Mariana de Mendonça, Anaysa Paola Bolin, Nayara Preste de Oliveira, Caroline Cristiano Real, Xiaoyun Hu, Zhan-Peng Huang, Da-Zhi Wang, Alice Cristina Rodrigues
During inguinal adipose tissue (iWAT) ontogenesis, beige adipocytes spontaneously appear between postnatal 10 (P10) and P20 and their ablation impairs iWAT browning capacity in adulthood. Since maternal obesity has deleterious effects on offspring iWAT function, we aimed to investigate its effect in spontaneous iWAT browning in offspring. Female C57BL/6 J mice were fed a control or obesogenic diet
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Light deficiency in Apoe−/−mice increases atheroma plaque size and vulnerability by modulating local immunity BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-07 Gema Hurtado-Genovés, Andrea Herrero-Cervera, Ángela Vinué, Susana Martín-Vañó, María Aguilar-Ballester, Alida Taberner-Cortés, Elena Jiménez-Martí, Sergio Martínez-Hervás, Herminia González-Navarro
Previous research suggests a potential involvement of the cytokine LIGHT (TNFSF14) in atherosclerosis. In this study, the genetic inactivation of in Apolipoprotein E deficient mice (male and female C57BL) augmented plaque size and vulnerability while decreasing Treg cells. Human and mouse transcriptomic results demonstrated deranged immune pathways in human atheromas with low expression levels and
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Discovery of 2,8-dihydroxyadenine in HUA patients with uroliths and biomarkers for its associated nephropathy BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-07 Xiaohong Zheng, Xiaowei Lu, Qiuxian Li, Shiting Gong, Baoyi Chen, Qingfeng Xie, Fang Yan, Jincan Li, Ziren Su, Yuhong Liu, Zhonghui Guo, Jiannan Chen, Yucui Li
Currently, it is acknowledged that gout is caused by uric acid (UA). However, some studies have revealed no correlation between gout and UA levels, and growing evidence suggests that 2,8-dihydroxyadenine (2,8-DHA), whose structural formula is similar to UA but is less soluble, may induce gout. Hence, we hypothesized that uroliths from hyperuricemia (HUA) patients, which is closely associated with gout
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HNRNPA2B1 and HNRNPR stabilize ASCL1 in an m6A-dependent manner to promote neuroblastoma progression BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-06 Ting Hu, Chong Zeng, Zhihao Song, Qing Liu, Si Chen, Wei Huang, Qianquan Ma, Haoyu Li
HNRNPA2B1 and HNRNPR stabilize mRNA in neuroblastoma, but whether their regulatory effects depend on m6A modification and whether their function involves ASCL1 remain unknown. This study investigated the m6A-dependent binding of HNRNPA2B1 and HNRNPR to ASCL1 and subsequent regulation, as well as the expression, clinical significance, and function of HNRNPA2B1 and HNRNPR in neuroblastoma. We revealed
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Bile acids mediate fructose-associated liver tumour growth in mice BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-06 Stefan Hargett, Sujoy Lahiri, Greg M. Kowalski, Susan Corley, Marin E. Nelson, Carolin Lackner, Ellen M. Olzomer, Isabella Aleksovska, Brandon A. Hearn, Riya Shrestha, Michael Janitz, Mark D. Gorrell, Clinton R. Bruce, Marc Wilkins, Kyle L. Hoehn, Frances L. Byrne
High fructose diets are associated with an increased risk of liver cancer. Previous studies in mice suggest increased lipogenesis is a key mechanism linking high fructose diets to liver tumour growth. However, these studies administered fructose to mice at supraphysiological levels. The aim of this study was to determine whether liver tumour growth and lipogenesis were altered in mice fed fructose
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DMT1-mediated iron overload accelerates cartilage degeneration in Hemophilic Arthropathy through the mtDNA-cGAS-STING axis BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-06 Haigang Liu, Ruimin Chi, Jingting Xu, Jiachao Guo, Zhou Guo, Xiong Zhang, Liangcai Hou, Zehang Zheng, Fan Lu, Tao Xu, Kai Sun, Fengjing Guo
Excess iron contributes to Hemophilic Arthropathy (HA) development. Divalent metal transporter 1 (DMT1) delivers iron into the cytoplasm, thus regulating iron homeostasis. We aimed to investigate whether DMT1-mediated iron homeostasis is involved in bleeding-induced cartilage degeneration and the molecular mechanisms underlying iron overload-induced chondrocyte damage. This study established an in
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Therapeutic potential of AAV-FL-Klotho in obesity: Impact on weight loss and lipid metabolism in mice BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-05 Min-Jung Park, Junhyeong Lee, Bernadette B. Bagon, Merc Emil Matienzo, Chang-Min Lee, Keon Kim, Dong-il Kim
Klotho, an anti-aging protein, has gained attention for its protective effects against various diseases, including metabolic disorders, through recombinant Klotho administration. However, the potential of Klotho as a target for gene therapy requires further exploration, as it remains relatively understudied in the context of metabolic disorders. In this study, we demonstrate that AAV-full length(FL)-Klotho
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MT-TN mutations lead to progressive mitochondrial encephalopathy and promotes mitophagy BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-05 Haolin Duan, Cunhui Pan, Tenghui Wu, Jing Peng, Li Yang
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Melatonin ameliorates retinal ganglion cell senescence and apoptosis in a SIRT1-dependent manner in an optic nerve injury model BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-05 Yuxun Shi, Dan Ye, Kaixuan Cui, Xue Bai, Matthew Fan, Yanlin Feng, Chenyang Hu, Yue Xu, Jingjing Huang
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Vildagliptin inhibits high fat and fetuin-A mediated DPP-4 expression, intracellular lipid accumulation and improves insulin secretory defects in pancreatic beta cells BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-29 Snehasish Nag, Samanwita Mandal, Oindrila Mukherjee, Tanmay Majumdar, Satinath Mukhopadhyay, Rakesh Kundu
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Trends in 3D models of inflammatory bowel disease BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-29 Bárbara Ferreira, Andreia S. Barros, Catarina Leite-Pereira, Juliana Viegas, José das Neves, Rute Nunes, Bruno Sarmento
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TIMP1/CHI3L1 facilitates glioma progression and immunosuppression via NF-κB activation BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-28 Jianye Xu, Cheng Wei, Cong Wang, Fanjian Li, Zhitao Wang, Jianhua Xiong, Yuan Zhou, Shenghui Li, Xiao Liu, Guili Yang, Lei Han, Jianning Zhang, Shu Zhang
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Mac-1 deficiency ameliorates pressure overloaded heart failure through inhibiting macrophage polarization and activation BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-30 Qiu-Yue Lin, Wei-Jia Yu, Jie Bai, Wen-Xi Jiang, Hui-Hua Li
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Impact of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) on the expression and function of hepatobiliary transporters: A comprehensive mechanistic review BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-31 Ankit P. Laddha, Lindsey Dzielak, Cedric Lewis, Raymond Xue, José E. Manautou
The liver plays a central role in the biotransformation and disposition of endogenous molecules and xenobiotics. In addition to drug-metabolizing enzymes, transporter proteins are key determinants of drug hepatic clearance. Hepatic transporters are transmembrane proteins that facilitate the movement of chemicals between sinusoidal blood and hepatocytes. Other drug transporters translocate molecules
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Targeting TOP2B as a vulnerability in aging and aging-related diseases BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-30 Man Zhu, Hao Li, Yi Zheng, Jing Yang
The ongoing trend of rapid aging of the global population has unavoidably resulted in an increase in aging-related diseases. There is an immense amount of interest in the scientific community for the identification of molecular targets that may effectively mitigate the process of aging and aging-related diseases. The enzyme Topoisomerase IIβ (TOP2B) plays a crucial role in resolving the topological
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Exercise ameliorates lipid droplet metabolism disorder by the PLIN2–LIPA axis-mediated lipophagy in mouse model of non-alcoholic fatty liver disease BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-02-02 Chunlu Fang, Shujing Liu, Wenqi Yang, Guohua Zheng, Fu Zhou, Xiang Gao, Lian Qin, Guirong Yang, Jiapei Yang, Guangming Zhu, Xinzhuang Wang, Kailing Huang, Xincheng Yang, Yuan Wei, Shuang Peng, Liangming Li
Excessive hepatic lipid droplets (LDs) accumulation-induced lipid metabolism disorder contributes to the development of non-alcoholic fatty liver disease (NAFLD). Exercise is a promising therapeutic strategy for NAFLD. However, the mechanism by which exercise ameliorates NAFLD through regulating the catabolism of hepatic LDs remains unclear. In the present study, we investigated the effect of perilipin2
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Golden bifid treatment regulates gut microbiota and serum metabolites to improve myocardial dysfunction in cecal ligation and puncture-induced sepsis mice BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-30 Rui Wu, Junmei Xu, Hua Zeng, Yongmei Fan, Hui Li, Tian Peng, Feng Xiao
Myocardial damage is a major consequence and a significant contributor to death in cases of sepsis, a severe infection characterized by a distinct inflammatory response and a potential threat to the patient's life. Recently, the effects of intestinal microbiota and serum metabolites on sepsis have garnered increasing attention. Herein, the effects of golden bifid treatment upon cecal ligation and puncture
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Influence of FTDP-17 mutants on circular tau RNAs BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-28 Giorgi Margvelani, Justin R. Welden, Andrea Arizaca Maquera, Jennifer E. Van Eyk, Christopher Murray, Sandra C. Miranda Sardon, Stefan Stamm
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The striking differences in the bioenergetics of brain and liver mitochondria are enhanced in mitochondrial disease BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-26 Valeria Balmaceda, Timea Komlódi, Marten Szibor, Erich Gnaiger, Anthony L. Moore, Erika Fernandez-Vizarra, Carlo Viscomi
Mitochondrial disorders are hallmarked by the dysfunction of oxidative phosphorylation (OXPHOS) yet are highly heterogeneous at the clinical and genetic levels. Striking tissue-specific pathological manifestations are a poorly understood feature of these conditions, even if the disease-causing genes are ubiquitously expressed. To investigate the functional basis of this phenomenon, we analyzed several
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GLUT1 mediates the release of HMGB1 from airway epithelial cells in mixed granulocytic asthma BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-27 Haixiong Tang, Yubiao Guo, Sudan Gan, Zemin Chen, Meihua Dong, Liqin Lin, Huifang Chen, Xiaolong Ji, Mo Xian, Xu Shi, Ailin Tao, Yanhua Lv, Lihong Yao, Ruchong Chen, Shiyue Li, Jing Li
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C/EBPα aggravates renal fibrosis in CKD through the NOX4-ROS-apoptosis pathway in tubular epithelial cells BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-27 Ziru Xia, Zhaonan Wei, Xin Li, Yunzi Liu, Xiangchen Gu, Siyi Huang, Xiaoyue Zhang, Weiming Wang
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NAD in pathological cardiac remodeling: Metabolic regulation and beyond BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-27 Ignacio Norambuena-Soto, Yingfeng Deng, Charles Brenner, Sergio Lavandero, Zhao V. Wang
Nicotinamide adenine dinucleotide (NAD) coenzymes are carriers of high energy electrons in metabolism and also play critical roles in numerous signaling pathways. NAD metabolism is decreased in various cardiovascular diseases. Importantly, stimulation of NAD biosynthesis protects against heart disease under different pathological conditions. In this review, we describe pathways for both generation
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NLRP6 deficiency suppresses colorectal cancer liver metastasis growth by modulating M-MDSC-induced immunosuppressive microenvironment BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-25 Liangzheng Chang, Lei Xu, Yuying Tian, Zherui Liu, Meiru Song, Shuang Li, Xinfeng Zhang, Yue Chen, Qiuyao Hao, Yinying Lu, Yunhuan Zhen
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Cereblon-mediated TRPC1 degradation regulates Ca2+ influx in the heart BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-23 Nammi Park, Jubert Marquez, Nguyen Thi Tuyet Anh, Jessa Flores, Maria Victoria Faith Garcia, Ippei Shimizu, Joohyun Nam, Bernd Nilius, Hyoung Kyu Kim, Jin Han
• This study investigated how cereblon (CRBN), a substrate receptor of the E3 ubiquitin ligase complex that selectively degrades ion channels, targets cardiac transient receptor potential channel 1 (TRPC1). • Physiologically, CRBN ablation upregulated TRPC1 expression. • Mechanistically, the CRBN Lon domain directly interacts with the C- and N-terminals of TRPC1. • Increasing CRBN levels enhanced TRPC1
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Effect of l-serine and magnesium ions on the functional properties of human phosphoserine phosphatase and its pathogenetic variants BBA Mol. Basis Dis. (IF 6.2) Pub Date : 2024-01-24 Francesco Marchesani, Valeria Buoli Comani, Stefano Bruno, Andrea Mozzarelli, Mauro Carcelli, Loredano Pollegioni, Laura Caldinelli, Alessio Peracchi, Barbara Campanini
L-Ser supply in the central nervous system of mammals mostly relies on its endogenous biosynthesis by the phosphorylated pathway (PP). Defects in any of the three enzymes operating in the pathway result in a group of neurometabolic diseases collectively known as serine deficiency disorders (SDDs). Phosphoserine phosphatase (PSP) catalyzes the last, irreversible step of the PP. Here we investigated