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Immunosuppression Withdrawal in Living-donor Renal Transplant Recipients Following Induction with Anti-thymocyte Globulin and Rituximab: Results of a Prospective Clinical Trial Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-11 James F. Markmann, Bryna E. Burrell, Jonathan S. Bromberg, Choli Hartono, Dixon B. Kaufman, Andrew M. Possselt, Ali Naji, Nancy D. Bridges, Cynthia Breeden, Sai Kanaparthi, Jorge Pardo, Heather Kopetskie, Kristen Mason, Noha Lim, Sindhu Chandran
Durable tolerance in kidney transplant recipients remains an important but elusive goal. We hypothesized that adding B cell depletion to T cell depletion would generate an immune milieu post-reconstitution dominated by immature transitional B cells, favoring tolerance. The Immune Tolerance Network ITN039ST RESTARRT was a prospective multicenter pilot study of live donor kidney transplant recipients
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Banff 2022 liver group meeting report: monitoring long term allograft health Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-09 Christopher O.C. Bellamy, Jacqueline G. O'Leary, Oyedele Adeyi, Nahed Baddour, Ibrahim Batal, John Bucuvalas, Arnaud Del Bello, Mohamed El Hag, Magda El-Monayeri, Alton B. Farris III, Sandy Feng, Maria Isabel Fiel, Sandra E. Fischer, John Fung, Krzysztof Grzyb, Maha Guimei, Hironori Haga, John Hart, Annette M. Jackson, Elmar Jaeckel, Nigar A. Khurram, Stuart J. Knechtle, Drew Lesniak, Josh Levitsky
The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists and histocompatibility specialists. Presentations and discussions focused on the evaluation of long-term allograft health, including non-invasive and tissue monitoring, immunosuppression optimisation and long-term structural changes. Potential revision
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Letter to the Editor Living organ donation in polarized societies Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Eytan Mor M.D.
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Morning Administration Enhances Humoral Response to SARS-CoV-2 Vaccination in Kidney Transplant Recipients Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Ivan Zahradka, Filip Tichanek, Maria Magicova, Istvan Modos, Ondrej Viklicky, Vojtech Petr
Although SARS-CoV-2 mRNA vaccines are effective in kidney transplant recipients (KTRs), their immune response to vaccination is blunted by immunosuppression. Other tools enhancing vaccination response are therefore needed. Interestingly, aligning vaccine administration with circadian rhythms (chronovaccination) was shown to boost immune response. However, its applicability in KTRs, whose circadian
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Successful lung transplantation in genetic MARS-related alveolar proteinosis/lung fibrosis without recurrence under methionine supplementation:medium-term outcome in 4 cases. Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Charlotte Roy, Nathalie Allou, Aurore Coulomb, Dominique Grenet, Raphaël Borie, Benjamin Zuber, Abdulmonem Hamid, Matthieu Glorion, Anne-Laure Brun, Elizabeth Longchamps, Alice Hadchouel, Olivier Brugiere
Pulmonary alveolar proteinosis (PAP) results from the accumulation of lipoproteinaceous material in the alveoli and alveolar macrophages, and can be associated with pulmonary fibrosis (PAP-PF), with a need for lung transplantation (LTx). Causes of PAP are autoimmune (90-95%), secondary (5%), or hereditary (<1%). Patients with hereditary PAP are generally not considered for isolated LTx, due to the
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Racism and tolerance in live kidney donation in Israel – response to Nesher et al Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Ayelet Shai MD PhD
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Functional maturation and longitudinal imaging of intraportal neonatal porcine islet grafts in genetically diabetic pigs Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-01 Johanna Pilz, Nicol Gloddek, Felix Lindheimer, Magdalena J. Lindner, Daniel Puhr-Westerheide, Muzzafer Ümütlü, Clemens Cyran, Max Seidensticker, Richard Lindner, Martin Kraetzl, Simone Renner, Daphne Merkus, Daniel Teupser, Peter Bartenstein, Sibylle I. Ziegler, Eckhard Wolf, Elisabeth Kemter
Allogeneic intraportal islet transplantation (ITx) has become an established treatment for patients with poorly controlled type 1 diabetes. However, the loss of viable beta-cell mass after transplantation remains a major challenge. Therefore, noninvasive imaging methods for long-term monitoring of the transplant fate are required. In this study, [Ga]Ga-DOTA-exendin-4 positron emission tomography/computed
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Subsequent kidney transplant after pediatric heart transplant: Prevalence and risk factors Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Lucas D.G. Barrett, Kelli K. Ryckman, Amber M. Goedken, Emily Jane S. Steinbach, Ellen van der Plas, Gary Beasley, Rabia S. Khan, Vernat Exil, David A. Axelrod, Lyndsay A. Harshman
Pediatric heart failure and transplantation carry associated risks for kidney failure and potential need for kidney transplant following pediatric heart transplantation (KT/pHT). This retrospective, United Network of Organ Sharing study of 10 030 pediatric heart transplants (pHTs) from 1987 to 2020 aimed to determine the incidence of waitlisting for and completion of KT/pHT, risk factors for KT/pHT
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Challenging boundaries: Organ transplants from donors with listeria central nervous system infections Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Richard Lueking, Monica Fung, Elizabeth Ramos-Salazar, Sreelatha Katari, Geoffrey A. Funk, Cameron R. Wolfe, Ricardo M. La Hoz
Pretransplant mortality rates in the US remain high and are connected to effective organ donation and utilization. Thus, there is a need to maximize the utilization of available donors. In some cases, this has been safely achieved using organs from donors with infectious complications. For example, several studies describe the use of organs from donors with bacterial meningitis due to pathogens such
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Biliary complications after adult-to-adult living-donor liver transplantation: An international multicenter study of 3633 cases Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-28 Zhihao Li, Ashwin Rammohan, Vasanthakumar Gunasekaran, Suyoung Hong, Itsuko Chih-Yi Chen, Jongman Kim, Kris Ann Hervera Marquez, Shih Chao Hsu, Elvan Onur Kirimker, Nobuhisa Akamatsu, Oren Shaked, Michele Finotti, Marcus Yeow, Lara Genedy, Philipp Dutkowski, Silvio Nadalin, Markus U. Boehnert, Wojciech G. Polak, Glenn K. Bonney, Abhishek Mathur, Benjamin Samstein, Jean C. Emond, Giuliano Testa, Kim
In living-donor liver transplantation, biliary complications including bile leaks and biliary anastomotic strictures remain significant challenges, with incidences varying across different centers. This multicentric retrospective study (2016-2020) included 3633 adult patients from 18 centers and aimed to identify risk factors for these biliary complications and their impact on patient survival. Incidences
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Reevaluating severe acute respiratory syndrome coronavirus-2 donor testing policies: Balancing safety and efficiency in organ transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-27 Stephanie M. Pouch, Ricardo M. La Hoz
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Excess waitlist mortality among candidates for multivisceral liver-intestine transplant in acuity circle allocation Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-24 Allison J. Kwong, Erin Schnellinger, Julia Foutz, Matt Cafarella, Shunji Nagai, Scott W. Biggins, James Pomposelli, James Trotter
Candidates for multivisceral transplant (MVT) have experienced decreased access to transplant in recent years. Using Organ Procurement and Transplantation Network data, transplant and waiting list outcomes for MVT (ie, liver-intestine, liver-intestine-pancreas, and liver-intestine-kidney-pancreas) candidates listed between February 4, 2018, and February 3, 2022, were analyzed, including model for end-stage
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Impact of deceased organ donor marijuana use on donor culture positivity and solid organ transplant recipient outcomes Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-23 Krista Moore, Ebbing Lautenbach, Emily A. Blumberg, Jennifer Han, Dong Heun Lee, Heather Clauss, Richard Hasz, Warren B. Bilker, Esther Molnar, Darcy Alimenti, Sharon West, Pam Tolomeo, Judith A. Anesi
With the increasing prevalence of marijuana use in the US, many deceased organ donors have a history of marijuana use, raising concerns about infectious risks to transplant recipients. We performed a multicenter retrospective cohort study in which exposed donors were those with recent marijuana use (in the prior 12 months) and unexposed donors were those with no recent marijuana use. Primary outcomes
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Fibrotic progression from acute cellular rejection is dependent on secondary lymphoid organs in a mouse model of chronic lung allograft dysfunction Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-23 Katsutaka Mineura, Satona Tanaka, Yasufumi Goda, Yuriko Terada, Akihiko Yoshizawa, Keisuke Umemura, Atsuyasu Sato, Yoshito Yamada, Yojiro Yutaka, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Toshi Mennju, Daniel Kreisel, Hiroshi Date
Chronic lung allograft dysfunction (CLAD) remains one of the major limitations to long-term survival after lung transplantation. We modified a murine model of CLAD and transplanted left lungs from BALB/c donors into B6 recipients that were treated with intermittent cyclosporine and methylprednisolone postoperatively. In this model, the lung allograft developed acute cellular rejection on day 15 which
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Application of HLA molecular level mismatching in ethnically diverse kidney transplant recipients receiving a steroid-sparing immunosuppression protocol Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-23 Eva Santos, Katrina Spensley, Nicola Gunby, Judith Worthington, Candice Roufosse, Arthi Anand, Michelle Willicombe
Defining HLA mismatch at the molecular compared with the antigen level has been shown to be superior in predicting alloimmune responses, although data from across different patient populations are lacking. Using HLA-Matchmaker, HLA-EMMA and PIRCHE-II, this study reports on the association between molecular mismatch (MolMM) and de novo donor-specific antibody (dnDSA) in an ethnically diverse kidney
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Obesity is associated with a higher incidence of rejection in patients on belatacept: A pooled analysis from the BENEFIT/BENEFIT-EXT clinical trials Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-21 Nicholas W. Lange, Kristen King, Syed Ali Husain, David M. Salerno, Demetra S. Tsapepas, Jessica Hedvat, Miko Yu, Sumit Mohan
Though belatacept is administered with a weight-based dosing schema, there has been higher clearance reported in obese patients. Therefore, we evaluated the association between body mass index (BMI) and transplant outcomes in kidney transplant recipients who were randomized to cyclosporine- or belatacept-based immunosuppression in the BENEFIT and BENEFIT-EXT randomized clinical trials. A total of 666
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Outcomes in solid organ transplant recipients with a pretransplant diagnosis of melanoma Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-20 Fiona O. Zwald, Michael R. Sargen, April A. Austin, Mei-Chin Hsieh, Karen Pawlish, Jie Li, Charles F. Lynch, Kelly J. Yu, Eric A. Engels
Melanoma causes significant morbidity in solid organ transplant recipients (SOTRs). Melanomas diagnosed before transplantation can recur with intensive immunosuppression, but outcomes have not been well studied. We evaluated 901 non-Hispanic White SOTRs with a pretransplant melanoma identified using linked transplant and cancer registry data in the United States. Most pretransplant melanomas were invasive
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Updated 2024 US vaccine recommendations from the Advisory Committee on Immunization Practices Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-17 Marcus R. Pereira
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Inflammatory and hypoxic stress-induced islet exosomes released during isolation are associated with poor transplant outcomes in islet autotransplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-15 Prathab Balaji Saravanan, Jagan Kalivarathan, Kaeden McClintock, Shujauddin Mohammed, Elijah Burch, Christiane Morecock, Jinze Liu, Aamir Khan, Marlon F. Levy, Mazhar A. Kanak
Islets experience enormous stress during the isolation process, leading to suboptimal endocrine function after total pancreatectomy with islet autotransplantation (TPIAT). Our investigation focused on inducing isolation stress in islets ex vivo, where proinflammatory cytokines and hypoxia prompted the release of stress exosomes (exo) sized between 50 and 200 nm. Mass spectrometry analysis revealed
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Circadian clocks drive rhythmic antitumor immune responses mediated by migratory dendritic cells Am. J. Transplant. (IF 8.8) Pub Date : 2023-12-28 Simon N. Chu, James M. Gardner
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Creating an International Standard: Global Convergence in Transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2023-12-26 Lara C. Pullen PhD
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Emerging Multidrug-Resistant Salmonella Strain in United States Am. J. Transplant. (IF 8.8) Pub Date : 2023-12-19 Marcus R. Pereira
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Minimally invasive right lobe living donor hepatectomy: When benefits do not outweigh risks Am. J. Transplant. (IF 8.8) Pub Date : 2023-12-09 Deniz Balci
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Organoids protect ischemic tissue injury via macrophage polarization. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-24 Samson Hennessy-Strahs,Xian C Li
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Continuous Distribution: A Tool for Translating Science to Policy: The new, more flexible approach to organ allocation has been a long time coming. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-22 Lara C Pullen
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Comparison of HLA immunological risk stratification methods in lung transplantation. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-17 Steven J Hiho,Bronwyn J Levvey,Mary B Diviney,Gregory I Snell,Lucy C Sullivan,Glen P Westall
Outcomes following lung transplantation (LTx) remain poor, despite advances in sequencing technology and development of algorithms defining immunological compatibility. Presently, there is no consensus regarding the best approach to define HLA compatibility in LTx. Here, we compared five different HLA compatibility tools in a high-resolution HLA typed, clinically characterized cohort, to determine
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Exploring The Single Cell Immune Landscape Of Renal Allograft Inflammation Using Imaging Mass Cytometry. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-16 Mariam P Alexander,Mark Zaidi,Nicholas B Larson,Aidan Muller,Kevin Pavelko,Mark Stegall,Andrew Bentall,Bradly G Wouters,Trevor D McKee,Timucin Taner
Kidney allograft inflammation, mostly attributed to rejection and infection, is an important cause of graft injury and loss. Standard histopathological assessment of allograft inflammation provides limited insights into biological processes and immune landscape. Here, using Imaging Mass Cytometry (IMC) with a panel of 28 validated biomarkers, we explored the single-cell landscape of kidney allograft
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Semidirected Living Donors in Israel: Sociodemographic Profile, Religiosity, and Social Tolerance. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-15 Eviatar Nesher,Rachel Michowiz,Hagai Boas
Living kidney donations in Israel come from 2 sources: family members and individuals who volunteer to donate their kidney to patients with whom they do not have personal acquaintance. We refer to the first group as directed living donors (DLDs) and the second as semidirected living donors (SDLDs). The incidence of SDLD in Israel is ∼60%, the highest in the world. We introduce results of a survey among
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Temporal correlation between postreperfusion complement deposition and severe primary graft dysfunction in lung allografts. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-15 Emily Cerier,Chitaru Kurihara,Taisuke Kaiho,Takahide Toyoda,Adwaiy Manerikar,Viswajit Kandula,Benjamin Thomae,Yuriko Yagi,Anjana Yeldandi,Samuel Kim,Diego Avella-Patino,John Pandolfino,Harris Perlman,Benjamin Singer,G R Scott Budinger,Kalvin Lung,Borislav Alexiev,Ankit Bharat
Growing evidence implicates complement in the pathogenesis of primary graft dysfunction (PGD). We hypothesized that early complement activation postreperfusion could predispose to severe PGD grade 3 (PGD-3) at 72 hours, which is associated with worst posttransplant outcomes. Consecutive lung transplant patients (n = 253) from January 2018 through June 2023 underwent timed open allograft biopsies at
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Adjunctive Glucocorticoid Therapy for Pneumocystis jirovecii Pneumonia in Solid Organ Transplant Recipients: A Multicenter Cohort, 2015-2020. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-15 Seyed M Hosseini-Moghaddam,Sagar Kothari,Atul Humar,Hanan Albasata,Zachary A Yetmar,Raymund R Razonable,Dionysios Neofytos,Matilde D'Asaro,Katia Boggian,Cedric Hirzel,Nina Khanna,Oriol Manuel,Nicolas J Mueller,Hannah Imlay,Dima Kabbani,Varalika Tyagi,Olivia C Smibert,Mohamed Nasra,Lauren Fontana,Karam M Obeid,Anna Apostolopoulou,Sean X Zhang,Nitipong Permpalung,Hind Alhatimi,Michael S Silverman,Henry
Solid organ transplant recipients (SOTRs) frequently receive adjunctive glucocorticoid therapy (AGT) for Pneumocystis jirovecii pneumonia (PJP). This multicenter cohort of SOTRs with PJP admitted to 20 transplant centers in Canada, the United States, Europe, and Australia, examined whether AGT was associated with a lower rate of all-cause intensive care unit (ICU) admission, 90-day in-hospital death
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Preemptive intravenous human immunoglobulin G suppresses BK polyomavirus replication and spread of infection in vitro. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-15 Noriaki Sato,Atsuko Shiraki,Keita P Mori,Kaoru Sakai,Yoshinori Takemura,Motoko Yanagita,Seiya Imoto,Kazunari Tanabe,Kimiyasu Shiraki
BK polyomavirus (BKPyV) infection causes various diseases in immunocompromised patients. Cells from human lung and kidney were infected with BKPyV and treated with commercially available intravenous immunoglobulin G (IVIG). Its effects on BKPyV replication and spread of infection were investigated, focusing on administration timing. IVIG treatment 3 h after infection suppressed BKPyV replication assessed
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Abdominal CT measurements of body composition and waitlist mortality in kidney transplant candidates. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-08 Evelien E Quint,Yi Liu,Omid Shafaat,Nidhi Ghildayal,Helen Crosby,Arun Kamireddy,Robert A Pol,Babak J Orandi,Dorry L Segev,Clifford Weiss,Mara A McAdams DeMarco
Body mass index (BMI) is often used to determine kidney transplant (KT) candidacy. However, this measure of body composition has several limitations, including the inability to accurately capture dry weight. Objective computed tomography (CT)-based measures may improve pre- KT risk stratification and capture physiologic aging more accurately. We quantified the association between CT-based body composition
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A propensity score matched analysis of liver transplantation outcomes in the setting of preservation solution shortage. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-06 William A Preston,Devon J Pace,Peter J Altshuler,Misung Yi,Haley Kittle,Sage Vincent,Kenneth Andreoni,Adam M Frank,Jaime M Glorioso,Carlo Ramirez,Warren R Maley,Ashesh P Shah,Adam S Bodzin
The recent shortage of University of Wisconsin (UW) solution prompted increased utilization of histidine-tryptophan-ketoglutarate (HTK) solution for liver graft preservation. This contemporary study analyzed deceased donor liver transplant outcomes following preservation with HTK vs. UW. Patients receiving deceased donor liver transplantations between 1/1/2019 and 6/30/2022 were retrospectively identified
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The Banff 2022 Kidney Meeting Work Plan: Data-driven Refinement of the Banff Classification for Renal Allografts. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-04 Candice Roufosse,Maarten Naesens,Mark Haas,Carmen Lefaucheur,Roslyn B Mannon,Marjan Afrouzian,Nada Alachkar,Olivier Aubert,Serena M Bagnasco,Ibrahim Batal,Chris O C Bellamy,Verena Broecker,Klemens Budde,Marian Clahsen-Van Groningen,Shana M Coley,Lynn D Cornell,Darshana Dadhania,Anthony J Demetris,Gunilla Einecke,Alton B Farris,Agnes B Fogo,John Friedewald,Ian W Gibson,Catherine Horsfield,Edmund Huang
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to a key focus on the impact of microvascular inflammation and biopsy-based transcript analysis on the Banff Classification, further sessions were devoted to other aspects of kidney transplant pathology, in particular
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Prevention of Mollicute transmitted infections from donor lungs after lung transplant. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-04 Chitaru Kurihara,Taisuke Kaiho,Ankit Bharat
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The 2022 Banff Meeting Lung Report. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-04 Elizabeth N Pavlisko,Benjamin A Adam,Gerald J Berry,Fiorella Calabrese,Nahir Cortes-Santiago,Carolyn H Glass,Martin Goddard,John R Greenland,Daniel Kreisel,Deborah J Levine,Tereza Martinu,Stijn E Verleden,S Sam Weigt,Antoine Roux
The Lung Session of the 2022 16th Banff Foundation for Allograft Pathology Conference-held in Banff, Alberta-focused on non-rejection lung allograft pathology and novel technologies for the detection of allograft injury. A multidisciplinary panel reviewed the state-of-the-art of current histopathologic entities, serologic studies, and molecular practices, as well as novel applications of digital pathology
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Response to “Need for functional validation of B cell trajectory in transplant tolerance” Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-04 Alessandro Alessandrini
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Inside look: Are noninvasive biomarkers up to standard? Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-03 Enver Akalin,Valeria R Mas
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Transplant recipient, care partner, and clinician perceptions of medication adherence monitoring technology: A mixed methods study. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-02 Grace S Lee-Riddle,Harald J Schmidt,Peter P Reese,Maria N Nelson,Rebecca Neergaard,Frances K Barg,Marina Serper
Medication nonadherence is a leading cause of graft loss. Adherence monitoring technologies-reminder texts, smart bottles, video-observed ingestion, and digestion-activated signaling pills-may support adherence. However, patient, care partner, and clinician perceptions of these tools are not well studied. We conducted qualitative individual semistructured interviews and focus groups among 97 participants
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The measure of impact: Proposal of quality metrics for solid organ transplant pharmacy practice Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-02 Mary Moss Chandran, Elizabeth Cohen, Christina Teeter Doligalski, Lyndsey J. Bowman, Tiffany E. Kaiser, David J. Taber
As healthcare continues its transition toward value-based care, it is increasingly important for transplant pharmacists to demonstrate their impact on patient care, health-related outcomes, and healthcare costs. Evidence-based quality and performance metrics are recognized as crucial tools for measuring the value of service. Yet, there is a lack of well-developed and agreed-upon specific metrics for
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How hard are the hard outcomes reported in national transplant registries? Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-02 Steven Chadban, John S. Gill
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Successful cryopreservation of functional kidney allografts using vitrification and nanorewarming. Am. J. Transplant. (IF 8.8) Pub Date : 2023-11-02 Charles G Rickert,James M Gardner
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Transplanting old organs promotes senescence in young recipients. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-31 Jasper Iske,Maximilian J Roesel,Friederike Martin,Andreas Schroeter,Tomohisa Matsunaga,Ryoichi Maenosono,Utkarsh Tripathi,Yao Xiao,Yeqi Nian,Barbara J Caldarone,Florian W R Vondran,Peter T Sage,Haruhito Azuma,Reza Abdi,Abdallah Elkhal,Tamar Pirtskhalava,Tamara Tchkonia,James L Kirkland,Hao Zhou,Stefan G Tullius
In clinical organ transplantation, donor and recipient ages may differ substantially. Old donor organs accumulate senescent cells that have the capacity to induce senescence in naïve cells. We hypothesized that the engraftment of old organs may induce senescence in younger recipients, promoting age-related pathologies. When performing isogeneic cardiac transplants between age-mismatched C57BL/6 old
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The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-28 Maarten Naesens,Candice Roufosse,Mark Haas,Carmen Lefaucheur,Roslyn B Mannon,Benjamin A Adam,Olivier Aubert,Georg A Böhmig,Jasper Callemeyn,Marian Clahsen-van Groningen,Lynn D Cornell,Anthony J Demetris,Cinthia B Drachenberg,Gunilla Einecke,Agnes B Fogo,Ian W Gibson,Philip Halloran,Luis G Hidalgo,Catherine Horsfield,Edmund Huang,Željko Kikić,Nicolas Kozakowski,Brian Nankivell,Marion Rabant,Parmjeet
The XVI-th Banff Meeting for Allograft Pathology was held at Banff, Alberta, Canada, from 19th to 23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark the 30th anniversary of the first Banff Classification, premeeting discussions were held on the past, present, and future of the Banff Classification. This report is a summary of the meeting highlights that were
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Ambient air pollution is associated with graft failure/death in pediatric liver transplant recipients. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-28 Jared E Yalung,Holly P Shifman,Erika Rasnick Manning,Andrew Beck,John Bucuvalas,Jennifer C Lai,Sharad I Wadhwani
Children exposed to disproportionately higher levels of air pollution experience worse health outcomes. In this population-based, observational registry study, we examine the association between air pollution and graft failure/death in children following liver transplantation (LT) in the US. We modeled the associations between air pollution (PM2.5) levels localized to the patient's ZIP code at the
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Opening a Door: Organ Donation, Transplantation, and Pediatricians. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-27 By Lara C Pullen
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Banff 2022 pancreas transplantation multidisciplinary report: Refinement of guidelines for T cell-mediated rejection, antibody-mediated rejection and islet pathology. Assessment of duodenal cuff biopsies and noninvasive diagnostic methods. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-21 Cinthia B Drachenberg,Maike Buettner-Herold,Pedro Ventura Aguiar,Catherine Horsfield,Alexei V Mikhailov,John C Papadimitriou,Surya V Seshan,Marcelo Perosa,Ugo Boggi,Pablo Uva,Michael Rickels,Krzyztof Grzyb,Lois Arend,Miriam Cuatrecasas,Maria Fernanda Toniolo,Alton B Farris,Karine Renaudin,Lizhi Zhang,Candice Roufousse,Angelika Gruessner,Rainer Gruessner,Raja Kandaswamy,Steven White,George Burke,Diego
The Banff pancreas working schema for diagnosis and grading of rejection is widely used for treatment guidance and risk stratification in centers that perform pancreas allograft biopsies. Since the last update, various studies have provided additional insight regarding the application of the schema and enhanced our understanding of additional clinicopathologic entities. This update aims to clarify
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Outcomes of early vs late treatment initiation in solid organ transplantation from HCV NAT+ donors to HCV-uninfected recipients: Results from the HCV-TARGET study. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-21 Wesam Aleyadeh,Elizabeth C Verna,Hany Elbeshbeshy,Mark S Sulkowski,Coleman Smith,Jama Darling,Richard K Sterling,Andrew Muir,Lucy Akushevich,Danie La,Norah Terrault,Michael W Fried,Jordan J Feld
Curative hepatitis C (HCV) therapy has increased transplantation from HCV-infected (NAT+) donors to HCV-uninfected recipients (D+/R-). We evaluated outcomes of early and late HCV-treatment among D+/R- non-liver organ transplants. Patients received HCV regimens per local standard (n=10 sites). Outcomes were compared between early and late treatment. Early treatment regimens (ETR) (n=56) were initiated
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Photobiomodulation promotes the functionality and viability of human pancreatic islets in basal conditions and under cytokine stress conditions. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-20 Quentin Perrier,Emily Tubbs,Pierre-Yves Benhamou,Cécile Moro,Sandrine Lablanche
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Clinical characteristics and outcomes of liver transplant recipients infected by Omicron during the opening up of the dynamic zero-coronavirus disease policy in China: A prospective, observational study. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-18 Wei Zhang,Rongrong Wang,Pingbo Jin,Xinyu Yu,Weili Wang,Yuntao Zhang,Xueli Bai,Tingbo Liang
We analyzed the characteristics, risk factors, outcomes, and post-coronavirus disease 2019 (COVID-19) symptoms in liver transplant recipients in China's late 2022 COVID-19 wave. Recipients with COVID-19 were enrolled from December 1, 2022, to January 31, 2023, and followed up until May 31, 2023. Baseline and characteristic data were collected. A total of 930 recipients were included, with a vaccination
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Pathologic-genomic correlation identified a novel variant in FN1 and established the diagnosis of recurrent fibronectin glomerulopathy in the kidney allograft. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-16 Ibrahim Batal,Samih H Nasr,Surendra Dasari,Astrid Weins,Natalie Vena,Michael B Stokes,Krzysztof Kiryluk,Gerald B Appel
Fibronectin glomerulopathy is a rare inherited kidney disease, characterized by abnormal accumulation of fibronectin in the glomeruli. We report an exceptional case of recurrent fibronectin glomerulopathy first diagnosed in the kidney allograft. The presence of IgA staining in the native kidney biopsy and the reported family history of IgA nephropathy had led to initial pretransplant diagnosis of IgA
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COVID-19 Vaccine Mandates and the Owl of Minerva (editorial). Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-13 Benjamin Hippen
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Risk of cytomegalovirus infection and subsequent allograft failure after pancreas transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-13 Zachary A. Yetmar, Yogish C. Kudva, Maria Teresa Seville, Wendelyn Bosch, Janna L. Huskey, Tambi Jarmi, Aleksandra Kukla, Patrick G. Dean, Raymund R. Razonable, Elena Beam
Cytomegalovirus (CMV) is a common cause of infection after transplantation, but few studies have evaluated its epidemiology, risk factors, and outcomes among pancreas transplant recipients. We performed a retrospective cohort study of adults who underwent pancreas transplantation from January 1, 2010, through December 31, 2020, at 3 sites in Arizona, Florida, and Minnesota. The primary outcome was
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Combined Heart Liver Transplantation in the Patients with Advanced Liver Disease and/or Hepatocellular Carcinoma: Why Can't Liver Pull the Heart? Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-13 Alexandra Shingina,Neha Bansal,Ari Cedars,Sharon Chen,Tami Daugherty,Juliet Emamaullee,Daniel Ganger,Jin Ge,Theo Heller,Dempsey Hughes,Joseph Kay,Juan Ortega Legaspi,Jonathan Menachem,Martin Montenovo,Jordan Sack,Leigh Reardon,Thomas Schiano,Kathleen Simpson,Jeffrey Teuteberg,Rose Tompkins,Irene Vodkin,Fred Wu,George Lui
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Report of the 2022 Banff Heart Concurrent: Focus on non-human leukocyte antigen antibodies in rejection and the pathology of "mixed" rejection. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-12 Marny Fedrigo,Gerald J Berry,Guillaume Coutance,Elaine F Reed,Chieh-Yu Lin,Alessia Giarraputo,Evan Kransdorf,Olivier Thaunat,Martin Goddard,Annalisa Angelini,Desley A H Neil,Patrick Bruneval,Jean-Paul Duong Van Huyen,Alexandre Loupy,Dylan V Miller
The Banff Heart Concurrent Session, held as part of the 16th Banff Foundation for Allograft Pathology Conference at Banff, Alberta, Canada, on September 21, 2022, focused on 2 major topics: non-human leukocyte antigen (HLA) antibodies and mixed rejection. Each topic was addressed in a multidisciplinary fashion with clinical, immunological, and pathology perspectives and future developments and prospectives
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Applying propensity methods to the United States transplant registry for external real-world evidence control arms for 5-year survival in the BENEFIT study Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-11 Amanda Klein, Alice Toll, Darren Stewart, William E. Fitzsimmons
To address the challenges of assessing the impact of a reasonably likely surrogate endpoint on long-term graft survival in prospective kidney transplant clinical trials, the Transplant Therapeutics Consortium established a real-world evidence workgroup evaluating the scientific value of using transplant registry data as an external control to supplement the internal control group. The United Network
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A scalable human islet 3D-culture platform maintains cell mass and function long-term for transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-07 Keiko Omori, Meirigeng Qi, Mayra Salgado, Nelson Gonzalez, Lauren T. Hui, Kuan-Tsen Chen, Jeffrey Rawson, Lynn Miao, Hirotake Komatsu, Jeffrey S. Isenberg, Ismail H. Al-Abdullah, Yoko Mullen, Fouad Kandeel
Present-day islet culture methods provide short-term maintenance of cell viability and function, limiting access to islet transplantation. Attempts to lengthen culture intervals remain unsuccessful. A new method was developed to permit the long-term culture of islets. Human islets were embedded in polysaccharide 3D-hydrogel in cell culture inserts or gas-permeable chambers with serum-free CMRL 1066
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Discretionary list diving optimizes kidney utilization. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-06 Robert J Stratta
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Living donor liver transplantation for colorectal cancer liver metastases: Midterm outcomes at a single center in North America. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-06 Christof Kaltenmeier,David A Geller,Swaytha Ganesh,Samer Tohme,Michele Molinari,Amit Tevar,Christopher Hughes,Abhinav Humar
In recent years, liver transplantation has emerged as a treatment for patients with stage IV colorectal liver metastases (CRLM). Given the limited number of available deceased donor grafts, the use of living donor liver transplantation (LDLT) can be an important option. We performed a retrospective analysis of 10 patients that underwent LDLT for CRLM at our institution. A total of 90% of patients were