-
Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans npj Aging Mech. Dis. Pub Date : 2024-03-08 Trevor H. Torigoe, D. Craig Willcox, Michio Shimabukuro, Moritake Higa, Mariana Gerschenson, Anastasia Andrukhiv, Makoto Suzuki, Brian J. Morris, Randi Chen, Greg S. Gojanovich, Richard C. Allsopp, Bradley J. Willcox
-
Effects of ageing and frailty on circulating monocyte and dendritic cell subsets npj Aging Mech. Dis. Pub Date : 2024-03-04 Rosanne D. Reitsema, Ashok K. Kumawat, Bernd-Cornèl Hesselink, Debbie van Baarle, Yannick van Sleen
-
Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases npj Aging Mech. Dis. Pub Date : 2024-02-27 Naomi Shek, Anna-Maria Choy, Chim C. Lang, Bruce E. Miller, Ruth Tal-Singer, Charlotte E. Bolton, Neil C. Thomson, James D. Chalmers, Matt J. Bown, David E. Newby, Faisel Khan, Jeffrey T. J. Huang
-
Your move: A precision medicine framework for physical activity in aging npj Aging Mech. Dis. Pub Date : 2024-02-27 Adrián Noriega de la Colina, Timothy P. Morris, Arthur F. Kramer, Navin Kaushal, Maiya R. Geddes
-
Cost of care for Alzheimer’s disease and related dementias in the United States: 2016 to 2060 npj Aging Mech. Dis. Pub Date : 2024-02-08 Arindam Nandi, Nathaniel Counts, Janina Bröker, Sabrina Malik, Simiao Chen, Rachael Han, Jessica Klusty, Benjamin Seligman, Daniel Tortorice, Daniel Vigo, David E. Bloom
-
Mitochondrial function in peripheral blood cells across the human lifespan npj Aging Mech. Dis. Pub Date : 2024-02-07 Johannes K. Ehinger, Emil Westerlund, Eleonor Åsander Frostner, Michael Karlsson, Gesine Paul, Fredrik Sjövall, Eskil Elmér
-
Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients’ treatment npj Aging Mech. Dis. Pub Date : 2024-02-06 V. Lelarge, R. Capelle, F. Oger, T. Mathieu, B. Le Calvé
-
The use of a systems approach to increase NAD+ in human participants npj Aging Mech. Dis. Pub Date : 2024-02-01 John D. Henderson, Sophia N. Z. Quigley, Shruti S. Chachra, Nichola Conlon, Dianne Ford
-
Attitudes and barriers towards deprescribing in older patients experiencing polypharmacy: a narrative review npj Aging Mech. Dis. Pub Date : 2024-01-23 Michael Robinson, Sophie Mokrzecki, Andrew J. Mallett
-
A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging npj Aging Mech. Dis. Pub Date : 2024-01-23 Annet Nicole Linders, Itamar Braga Dias, Teresa López Fernández, Carlo Gabriele Tocchetti, Nils Bomer, Peter Van der Meer
-
Cholesterol biosynthetic pathway induces cellular senescence through ERRα npj Aging Mech. Dis. Pub Date : 2024-01-12 Dorian V. Ziegler, Joanna Czarnecka-Herok, Mathieu Vernier, Charlotte Scholtes, Clara Camprubi, Anda Huna, Amélie Massemin, Audrey Griveau, Christelle Machon, Jérôme Guitton, Jennifer Rieusset, Arnaud M. Vigneron, Vincent Giguère, Nadine Martin, David Bernard
-
Machine learning prediction of hepatic steatosis using body composition parameters: A UK Biobank Study npj Aging Mech. Dis. Pub Date : 2024-01-09 Delbert Almerick T. Boncan, Yan Yu, Miaoru Zhang, Jie Lian, Varut Vardhanabhuti
-
An ensemble learning model for continuous cognition assessment based on resting-state EEG npj Aging Mech. Dis. Pub Date : 2024-01-02 Jingnan Sun, Yike Sun, Anruo Shen, Yunxia Li, Xiaorong Gao, Bai Lu
-
Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS) npj Aging Mech. Dis. Pub Date : 2024-01-02 Junya Unno, Kathryn F. Mills, Tairo Ogura, Masayuki Nishimura, Shin-ichiro Imai
-
The HLA-DRB1*09:01-DQB1*03:03 haplotype is associated with the risk for late-onset Alzheimer’s disease in APOE $${{\varepsilon }}$$ 4–negative Japanese adults npj Aging Mech. Dis. Pub Date : 2024-01-02 Daichi Shigemizu, Koya Fukunaga, Akiko Yamakawa, Mutsumi Suganuma, Kosuke Fujita, Tetsuaki Kimura, Ken Watanabe, Taisei Mushiroda, Takashi Sakurai, Shumpei Niida, Kouichi Ozaki
-
Mendelian randomization study supports the causal effects of air pollution on longevity via multiple age-related diseases npj Aging Mech. Dis. Pub Date : 2023-12-19 Shizheng Qiu, Yang Hu, Guiyou Liu
-
SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model npj Aging Mech. Dis. Pub Date : 2023-12-05 Pankaj Thapa, Katarzyna Olek, Agata Kowalska, Remigiusz A. Serwa, Wojciech Pokrzywa
-
Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma npj Aging Mech. Dis. Pub Date : 2023-11-21 Kota Sato, Daisuke Saigusa, Taiki Kokubun, Amane Fujioka, Qiwei Feng, Ritsumi Saito, Akira Uruno, Naomi Matsukawa, Michiko Ohno-Oishi, Hiroshi Kunikata, Yu Yokoyama, Masayuki Yasuda, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, Shigeto Maekawa, Masayuki Yamamoto, Toru Nakazawa
-
Low circulating adropin levels in late-middle aged African Americans with poor cognitive performance npj Aging Mech. Dis. Pub Date : 2023-11-09 Geetika Aggarwal, Theodore K. Malmstrom, John E. Morley, Douglas K. Miller, Andrew D. Nguyen, Andrew A. Butler
-
Spontaneous p53 activation in middle-aged C57BL/6 mice mitigates the lifespan-extending adaptive response induced by low-dose ionizing radiation npj Aging Mech. Dis. Pub Date : 2023-11-07 Masaoki Kohzaki, Keiji Suzuki, Akira Ootsuyama, Ryuji Okazaki
-
How does apathy impact exploration-exploitation decision-making in older patients with neurocognitive disorders? npj Aging Mech. Dis. Pub Date : 2023-10-30 Lyne Daumas, Raphaël Zory, Isabel Junquera-Badilla, Marion Ferrandez, Eric Ettore, Philippe Robert, Guillaume Sacco, Valeria Manera, Stephen Ramanoël
-
Assessing cognitive decline in the aging brain: lessons from rodent and human studies npj Aging Mech. Dis. Pub Date : 2023-10-19 D. V. C. Brito, F. Esteves, A. T. Rajado, N. Silva, I. Araújo, J. Bragança, P. Castelo-Branco, C. Nóbrega
-
Developing cognitive workload and performance evaluation models using functional brain network analysis npj Aging Mech. Dis. Pub Date : 2023-10-06 Saeed Shadpour, Ambreen Shafqat, Serkan Toy, Zhe Jing, Kristopher Attwood, Zahra Moussavi, Somayeh B. Shafiei
-
Accelerated epigenetic aging and decreased natural killer cells based on DNA methylation in patients with untreated major depressive disorder npj Aging Mech. Dis. Pub Date : 2023-09-06 Ryota Shindo, Takaki Tanifuji, Satoshi Okazaki, Ikuo Otsuka, Toshiyuki Shirai, Kentaro Mouri, Tadasu Horai, Akitoyo Hishimoto
-
Elevated plasma sclerostin is associated with high brain amyloid-β load in cognitively normal older adults npj Aging Mech. Dis. Pub Date : 2023-09-04 Jun Yuan, Steve Pedrini, Rohith Thota, James Doecke, Pratishtha Chatterjee, Hamid R. Sohrabi, Charlotte E. Teunissen, Inge M. W. Verberk, Erik Stoops, Hugo Vanderstichele, Bruno P. Meloni, Christopher Mitchell, Stephanie Rainey-Smith, Kathryn Goozee, Andrew Chi Pang Tai, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Junjie Gao, Delin Liu, Frank Mastaglia, Charles Inderjeeth, Minghao Zheng, Ralph
-
Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach npj Aging Mech. Dis. Pub Date : 2023-08-24 Dennyson Leandro M. Fonseca, Igor Salerno Filgueiras, Alexandre H. C. Marques, Elroy Vojdani, Gilad Halpert, Yuri Ostrinski, Gabriela Crispim Baiocchi, Desirée Rodrigues Plaça, Paula P. Freire, Shahab Zaki Pour, Guido Moll, Rusan Catar, Yael Bublil Lavi, Jonathan I. Silverberg, Jason Zimmerman, Gustavo Cabral-Miranda, Robson F. Carvalho, Taj Ali Khan, Harald Heidecke, Rodrigo J. S. Dalmolin, Andre
-
Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca2+ overload in Caenorhabditis elegans npj Aging Mech. Dis. Pub Date : 2023-08-01 XinTong Wu, Miku Seida, Takaaki Abe, Atsushi Higashitani
-
Unbiased proteomics and multivariable regularized regression techniques identify SMOC1, NOG, APCS, and NTN1 in an Alzheimer’s disease brain proteomic signature npj Aging Mech. Dis. Pub Date : 2023-07-06 Jackson A. Roberts, Vijay R. Varma, Julián Candia, Toshiko Tanaka, Luigi Ferrucci, David A. Bennett, Madhav Thambisetty
-
Biomarkers selection and mathematical modeling in biological age estimation npj Aging Mech. Dis. Pub Date : 2023-07-01 Solim Essomandan Clémence Bafei, Chong Shen
Biological age (BA) is important for clinical monitoring and preventing aging-related disorders and disabilities. Clinical and/or cellular biomarkers are measured and integrated in years using mathematical models to display an individual’s BA. To date, there is not yet a single or set of biomarker(s) and technique(s) that is validated as providing the BA that reflects the best real aging status of
-
Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity npj Aging Mech. Dis. Pub Date : 2023-07-01 Mei ElGindi, Jiranuwat Sapudom, Anna Garcia Sabate, Brian Chesney Quartey, Aseel Alatoom, Mohamed Al-Sayegh, Rui Li, Weiqiang Chen, Jeremy Teo
-
Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction npj Aging Mech. Dis. Pub Date : 2023-06-14 Rachael E. Redgrave, Emily Dookun, Laura K. Booth, Maria Camacho Encina, Omowumi Folaranmi, Simon Tual-Chalot, Jason H. Gill, W. Andrew Owens, Ioakim Spyridopoulos, João F. Passos, Gavin D. Richardson
-
Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration npj Aging Mech. Dis. Pub Date : 2023-06-01 Ghadir Elsamad, André Souza Mecawi, Audrys G. Pauža, Benjamin Gillard, Alex Paterson, Victor J. Duque, Olivera Šarenac, Nina Japundžić Žigon, Mingkwan Greenwood, Michael P. Greenwood, David Murphy
-
Cadmium, von Willebrand factor and vascular aging npj Aging Mech. Dis. Pub Date : 2023-06-01 Xia Wang, Maria N. Starodubtseva, Carolyn M. Kapron, Ju Liu
-
Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models npj Aging Mech. Dis. Pub Date : 2023-05-22 Alessandra Zonari, Lear E. Brace, Kallie Al-Katib, William F. Porto, Daniel Foyt, Mylieneth Guiang, Edgar Andres Ochoa Cruz, Bailey Marshall, Melissa Gentz, Gabriela Rapozo Guimarães, Octavio L. Franco, Carolina R. Oliveira, Mariana Boroni, Juliana L. Carvalho
-
Gut microbiota and circadian rhythm in Alzheimer’s disease pathophysiology: a review and hypothesis on their association npj Aging Mech. Dis. Pub Date : 2023-05-02 Mohammad Rafi Khezri, Morteza Ghasemnejad-Berenji
-
Recent insights into the crosstalk between senescent cells and CD8 T lymphocytes npj Aging Mech. Dis. Pub Date : 2023-04-04 Ines Marin, Manuel Serrano, Federico Pietrocola
-
Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans npj Aging Mech. Dis. Pub Date : 2023-04-03 A. Augusto Peluso, Agnete T. Lundgaard, Parizad Babaei, Felippe Mousovich-Neto, Andréa L. Rocha, Mads V. Damgaard, Emilie G. Bak, Thiyagarajan Gnanasekaran, Ole L. Dollerup, Samuel A. J. Trammell, Thomas S. Nielsen, Timo Kern, Caroline B. Abild, Karolina Sulek, Tao Ma, Zach Gerhart-Hines, Matthew P. Gillum, Manimozhiyan Arumugam, Cathrine Ørskov, Douglas McCloskey, Niels Jessen, Markus J. Herrgård
-
Aging reduces calreticulin expression and alters spontaneous calcium signals in astrocytic endfeet of the mouse dorsolateral striatum npj Aging Mech. Dis. Pub Date : 2023-03-31 Sara M. Zarate, Taylor E. Huntington, Pooneh Bagher, Rahul Srinivasan
-
Author Correction: How does hormesis impact biology, toxicology, and medicine? npj Aging Mech. Dis. Pub Date : 2023-03-31 Edward J Calabrese,Mark P Mattson
-
Factors for optimizing intervention programs for cognition in older adults: the value of exergames npj Aging Mech. Dis. Pub Date : 2023-03-29 Alexandra Perrot, Pauline Maillot
-
Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults npj Aging Mech. Dis. Pub Date : 2023-02-27 Marco Demaria, Beatrice Bertozzi, Nicola Veronese, Francesco Spelta, Edda Cava, Valeria Tosti, Laura Piccio, Dayna S. Early, Luigi Fontana
-
Increased activity of lacrimal gland mast cells are associated with corneal epitheliopathy in aged mice npj Aging Mech. Dis. Pub Date : 2023-02-27 Elsayed Elbasiony, WonKyung J. Cho, Aastha Singh, Sharad K. Mittal, Driss Zoukhri, Sunil K. Chauhan
-
Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus npj Aging Mech. Dis. Pub Date : 2023-01-25 Sean Johnson, Kiyoshi Yoshioka, Cynthia S. Brace, Shin-ichiro Imai
-
Multiple pathways promote microtubule stabilization in senescent intestinal epithelial cells npj Aging Mech. Dis. Pub Date : 2022-12-16 Siwei Chu, Ossama Moujaber, Serge Lemay, Ursula Stochaj
-
Identification of potential blood biomarkers for early diagnosis of Alzheimer’s disease through immune landscape analysis npj Aging Mech. Dis. Pub Date : 2022-11-04 Daichi Shigemizu, Shintaro Akiyama, Risa Mitsumori, Shumpei Niida, Kouichi Ozaki
-
Why do older adults stand-up differently to young adults?: investigation of compensatory movement strategies in sit-to-walk npj Aging Mech. Dis. Pub Date : 2022-09-05 Eline van der Kruk, Paul Strutton, Louis J. Koizia, Michael Fertleman, Peter Reilly, Anthony M. J. Bull
-
Integrated cognitive and physical fitness training enhances attention abilities in older adults npj Aging Mech. Dis. Pub Date : 2022-08-30 Joaquin A. Anguera, Joshua J. Volponi, Alexander J. Simon, Courtney L. Gallen, Camarin E. Rolle, Roger Anguera-Singla, Erica A. Pitsch, Christian J. Thompson, Adam Gazzaley
-
Age-dependent effects of blue light exposure on lifespan, neurodegeneration, and mitochondria physiology in Drosophila melanogaster npj Aging Mech. Dis. Pub Date : 2022-07-27 Yujuan Song, Jun Yang, Alexander D. Law, David A. Hendrix, Doris Kretzschmar, Matthew Robinson, Jadwiga M. Giebultowicz
-
Paracrine-mediated rejuvenation of aged mesenchymal stem cells is associated with downregulation of the autophagy-lysosomal pathway npj Aging Mech. Dis. Pub Date : 2022-07-18 George Hung, Tamara Ashvetiya, Aleksandra Leszczynska, Wanjun Yang, Chao-Wei Hwang, Gary Gerstenblith, Andreas S. Barth, Peter V. Johnston
-
Age-dependent cognitive impairment, hydrocephalus and leukocyte infiltration in transgenic mice with endothelial expression of human EPHX2 npj Aging Mech. Dis. Pub Date : 2022-07-05 Catherine M. Davis, Wenri H. Zhang, Thierno M. Bah, Natalie E. Roese, Elyse M. Allen, Philberta Leung, Sydney J. Boutros, Tessa Marzulla, Esha Patel, Xiao Nie, Farah N. Alkayed, Justin H. Huang, Michael A. Jensen, Jacob Raber, Martin M. Pike, Nabil J. Alkayed
-
Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice npj Aging Mech. Dis. Pub Date : 2022-06-27 Michel Bernier, Ignacio Navas Enamorado, Mari Carmen Gómez-Cabrera, Miguel Calvo-Rubio, Jose Antonio González-Reyes, Nathan L. Price, Ana Belén Cortés-Rodríguez, Juan Carlos Rodríguez-Aguilera, Sandra Rodríguez-López, Sarah J. Mitchell, Kelsey N. Murt, Krystle Kalafut, Katrina M. Williams, Christopher W. Ward, Joseph P. Stains, Gloria Brea-Calvo, Jose M. Villalba, Sonia Cortassa, Miguel A. Aon, Rafael
-
Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts npj Aging Mech. Dis. Pub Date : 2022-06-06 Chengjian Shi, Niser Babiker, Jacek K. Urbanek, Robert L. Grossman, Megan Huisingh-Scheetz, Andrey Rzhetsky
The prevalence of major neurocognitive disorders is expected to rise over the next 3 decades as the number of adults ≥65 years old increases. Noninvasive screening capable of flagging individuals most at risk of subsequent cognitive decline could trigger closer monitoring and preventive strategies. In this study, we used free-living accelerometry data to forecast cognitive decline within 1- or 5-years
-
Genetic associations with healthy ageing among Chinese adults npj Aging Mech. Dis. Pub Date : 2022-05-02 Xuling Chang, Yan-Feng Zhou, Ling Wang, Jianjun Liu, Jian-Min Yuan, Chiea-Chuen Khor, Chew-Kiat Heng, An Pan, Woon-Puay Koh, Rajkumar Dorajoo
The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have aged healthily and compared their genome-wide genotypes to 6221 participants who did not age healthily, after a 20-year follow-up. Two genetic variants were identified
-
Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men npj Aging Mech. Dis. Pub Date : 2022-05-01 Masaki Igarashi, Yoshiko Nakagawa-Nagahama, Masaomi Miura, Kosuke Kashiwabara, Keisuke Yaku, Mika Sawada, Rie Sekine, Yuichiro Fukamizu, Toshiya Sato, Takanobu Sakurai, Jiro Sato, Kenji Ino, Naoto Kubota, Takashi Nakagawa, Takashi Kadowaki, Toshimasa Yamauchi
Preclinical studies have revealed that the elevation of nicotinamide adenine dinucleotide (NAD + ) upon the administration of nicotinamide mononucleotide (NMN), an NAD + precursor, can mitigate aging-related disorders; however, human data on this are limited. We investigated whether the chronic oral supplementation of NMN can elevate blood NAD + levels and alter physiological dysfunctions in healthy
-
Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence npj Aging Mech. Dis. Pub Date : 2022-04-19 Ying Gao, Teru Kamogashira, Chisato Fujimoto, Shinichi Iwasaki, Tatsuya Yamasoba
The aim of this study was to investigate the effects of pyrroloquinoline quinone (PQQ), an oxidoreductase cofactor, on the H2O2-induced premature senescence model in HEI-OC1 auditory cells and to elucidate its mechanism of action in vitro. Cells were treated with PQQ for 1 day before H2O2 (100 μM) exposure. Mitochondrial respiratory capacity was damaged in this premature senescence model but was restored
-
A pan-tissue DNA-methylation epigenetic clock based on deep learning npj Aging Mech. Dis. Pub Date : 2022-04-19 Lucas Paulo de Lima Camillo, Louis R. Lapierre, Ritambhara Singh
Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been created in recent years, with the vast majority based on regularized linear regression. This study explores the improvement in the performance and interpretation of epigenetic clocks using deep learning. First, we gathered 142 publicly available data sets from several human tissues to develop AltumAge, a neural network
-
Mitochondrial DNA oxidative mutations are elevated in Mexican American women potentially implicating Alzheimer’s disease npj Aging Mech. Dis. Pub Date : 2022-04-04 Danielle Marie Reid, Robert C. Barber, Roland J. Thorpe, Jie Sun, Zhengyang Zhou, Nicole R. Phillips
Mexican Americans (MAs) are the fastest-growing Hispanic population segment in the US; as this population increases in age, so will the societal burden of age-related diseases such as Alzheimer’s disease (AD). Mitochondrial DNA (mtDNA) damage may be implicated in MA AD risk since metabolic comorbidities are more prevalent in this group. Oxidative damage to guanosine (8oxoG) is one of the most prevalent
-
The deleterious effects of old social partners on Drosophila lifespan and stress resistance npj Aging Mech. Dis. Pub Date : 2022-03-18 Yu-Chiao Lin, MingYang Zhang, Sheng-Hao Wang, Chia-Wen Chieh, Pin-Yun Shen, Yi-Lin Chen, Yu-Chia Chang, Tsung-Han Kuo
Social interactions play important roles in the modulation of behavior, physiology, and, potentially, lifespan. Although longevity has been studied extensively in different model organisms, due to the complexity of social environments, the social modulation of aging remains poorly investigated. The present study used the fruit fly, Drosophila melanogaster, as a model to study lifespan and stress resistance
-
Author Correction: Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease npj Aging Mech. Dis. Pub Date : 2021-12-01 Kristina Bečanović,Muhammad Asghar,Izabella Gadawska,Shiny Sachdeva,David Walker,Eduardo. R. Lazarowski,Sonia Franciosi,Kevin H. J. Park,Hélène C. F. Côté,Blair R. Leavitt
-
Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease npj Aging Mech. Dis. Pub Date : 2021-10-14 Kristina Bečanović, Asghar Muhammad, Izabella Gadawska, Shiny Sachdeva, David Walker, Eduardo. R. Lazarowski, Sonia Franciosi, Kevin H. J. Park, Hélène C. F. Côté, Blair R. Leavitt
Mitochondrial dysfunction and bioenergetics failure are common pathological hallmarks in Huntington’s disease (HD) and aging. In the present study, we used the YAC128 murine model of HD to examine the effects of mutant huntingtin on mitochondrial parameters related to aging in brain and skeletal muscle. We have conducted a cross-sectional natural history study of mitochondrial DNA changes in the YAC128