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The Role of Kynurenine Pathway Metabolites in the Development of Frailty in Older Adults Adv. Gerontol. Pub Date : 2024-03-07 V. S. Pykhtina
Abstract Frailty is the main geriatric syndrome, which is closely associated with age-related diseases and aging in general. Being considered the main pathogenetic mechanism of aging, low-grade chronic inflammation potentially contributes to increased degradation of the essential amino acid tryptophan through the kynurenine pathway. Active metabolites of the kynurenine pathway, when accumulated, implement
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The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease Adv. Gerontol. Pub Date : 2024-03-07 A. S. Fomin, S. P. Sergeeva
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The Rate of Aging and Its Association with Risk Factors of Cardiovascular Diseases Adv. Gerontol. Pub Date : 2024-03-07
Abstract Background: Biological age is a better predictor of morbidity and mortality associated with chronic age-related diseases than chronological age. The estimated difference between biological and chronological age can reveal an individual’s rate of aging. Aim: The aim of this study was to assess the association of cardiovascular risk factors with the rate of aging in people without cardiovascular
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Mechanisms of Neurocognitive Adaptation during Aging Process Adv. Gerontol. Pub Date : 2024-03-07 M. A. Cherdak
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Geroprotective Effect of the Mitochondrial-Targeted Antioxidant SkQBerb in a Model of the Chronological Aging of MB135 Human Myoblasts Adv. Gerontol. Pub Date : 2024-03-07 M. A. Chelombitko, G. V. Morgunova, N. Yu. Strochkova, K. G. Lyamzaev
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Senolytic Drugs: Implications for Clinical Practice Adv. Gerontol. Pub Date : 2024-03-07 A. K. Ilyushchenko, L. V. Matchekhina, O. N. Tkacheva, A. V. Balashova, A. A. Melnitskaia, A. V. Churov, I. D. Strazhesko
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Basic Epigenetic Mechanisms of Aging Adv. Gerontol. Pub Date : 2024-03-07 I. D. Strazhesko, A. P. Yesakova, A. A. Akopyan, O. N. Tkacheva
Abstract The process of aging is a complex biological phenomenon that is influenced by multiple factors, including genetics, environment, and lifestyle. Recent studies have shown that epigenetic modifications play an important role in the aging process, as they regulate gene expression and ultimately affect cellular function. Epigenetic modifications include DNA methylation, histone modification, and
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Gerontology in the 21st Century: From Failures to Advances. Hopefully Adv. Gerontol. Pub Date : 2024-02-22 A. N. Khokhlov
Abstract Editor-in-Chief of Advances in Gerontology describes the current editorial policy and the strategy of future development of the renewed journal which since 2023 is published as a separate independent edition. It is emphasized that now priority is given to publications devoted to (1) the fundamental mechanisms which may determine the increase in the probability of death of living organisms
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Comparative Analysis of Cell Senescence Induced by the Chemotherapeutic Agents Doxorubicin, Cisplatin and Arsenic Trioxide in Human Myoblasts MB135 Adv. Gerontol. Pub Date : 2024-02-22 M. A. Chelombitko, G. V. Morgunova, N. Yu. Strochkova, R. A. Zinovkin, A. N. Pavlyuchenkova, N. D. Kondratenko, K. G. Lyamzaev
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Reductionism and Holism in the History of Aging and Longevity Research: Does the Whole Have Parts? Part 1. The Building of Reductionism Adv. Gerontol. Pub Date : 2024-02-22 Ilia Stambler
Abstract The research of aging, rejuvenation and life extension has been notoriously characterized by a multitude of often contradictory approaches, both in terms of theoretical concepts as well as possible practical interventions. This work will explore a general taxonomy of these approaches that seems to be ubiquitous in the history of aging and longevity research. The taxonomy will juxtapose between
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Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues Adv. Gerontol. Pub Date : 2024-02-22 V. V. Yanshole, M. V. Fomenko, L. V. Yanshole, N. A. Osik, E. Y. Radomskaya, D. V. Bulgin, Y. P. Tsentalovich
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Mitochondrial Antioxidant SkQ1 Affects the GABAergic but Not the Glutamatergic System in the Hippocampus of Wistar and Senescence Accelerated OXYS Rats Adv. Gerontol. Pub Date : 2024-02-22 D. V. Telegina, N. G. Kolosova
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Reductionism and Holism in the History of Aging and Longevity Research: Does the Whole Have Parts? Part 2. The Upwelling of Holism Adv. Gerontol. Pub Date : 2024-02-15 Ilia Stambler
Abstract The opposition between reductionism and holism can be seen as an overarching theme in the history of aging, longevity and rejuvenation research. As a rule, the initial fascination with reductionist rejuvenation and life extension attempts, striving to tweak and rearrange parts of the human “machine,” in time, is superseded with more holistic perceptions of health maintenance in old age, emphasizing
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Patterns of Expression of the Key Genes of the BDNF System and Serotonin Receptors in the Brain of OXYS Rats in the Development of the Signs of Alzheimer’s Disease Adv. Gerontol. Pub Date : 2024-02-15 M. Alsallum, Ya. P. Kaminskaya, A. S. Tsybko, N. G. Kolosova, V. S. Naumenko
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Influence of AMPK on the Functioning of the Circadian Clock and Its Possible Role in the Development of Age-Related Metabolic Disorders Adv. Gerontol. Pub Date : 2024-02-15 G. V. Morgunova, G. A. Shilovsky, A. N. Khokhlov
Abstract Circadian rhythms ensure the synchronization of the physiology of cells and tissues in accordance with daily changes in the environment. These rhythms are maintained by transcriptional oscillators located in various organism cells. One of the rhythm sensors for the circadian clock is the intake of nutrients, this synchronizer is especially important in peripheral tissues. With age, the work
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Association between Telomere Length and Geriatric Status in Centenarians Adv. Gerontol. Pub Date : 2023-06-01
Abstract Aim: To evaluate the association between telomere length and frailty and individual geriatric syndromes in older adults. Materials and methods: The database of a hundred-year-old citizen of the city of Moscow was analyzed. The analysis was carried out using the data driven from the Comprehensive Geriatric Assessment (CGA), in particular, Age is not a Hindrance Scale, the Barthel index, Instrumental
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New Frailty Index Approach Predicts COVID-19 Mortality Risk Adv. Gerontol. Pub Date : 2023-03-01
Abstract The relationships between blood biomarkers, frailty, and the risk of death of people diagnosed with COVID-19 is unclear. In the current investigation we decided to analyze the collective effect of multiple biomarkers (laboratory markers of inflammation, blood biochemistry deviations, comorbidity, demographics) on mortality in people diagnosed with COVID-19. We analyzed baseline data of one
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On a New Paradigm of the Development of Neurodegenerative Diseases by the Example of Alzheimer’s Disease and Parkinson’s Disease Adv. Gerontol. Pub Date : 2022-12-22 I. V. Litvinenko, V. Yu. Lobzin
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Post-Retirement Employment among Iranian Older Adults: The Competition of Two Generation Adv. Gerontol. Pub Date : 2022-12-22 M. Basakha, M. S. Kermani, S. H. Mohaqeqi Kamal
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Influence of Perceived Ageism on Older Adults: Focus on Attitudes toward Young People and Life Satisfaction Adv. Gerontol. Pub Date : 2022-12-22 Y. Shimizu, M. Suzuki, Y. Hata, T. Sakaki
Abstract The world’s population is aging, and intergenerational conflicts between older adults and young people are becoming more serious. This study focused on ageism as a cause of intergenerational conflicts and older adults’ diminished mental health status. We conducted an online survey of older Japanese participants (n = 1.096). Our results indicated that older adults who perceived more ageism
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On the Role of Geriatric Services in the Diagnosis and Monitoring of Outcomes of Post-Covid Syndrome (Review) Adv. Gerontol. Pub Date : 2022-12-22 E. S. Lapteva, A. L. Ariev, G. T. Arieva, M. R. Tsutsunawa, D. C. Diachkova-Gerceva
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Healthy Life Expectancy of People Over Age 65: Results of the Russian Epidemiological Study EVCALIPT Adv. Gerontol. Pub Date : 2022-12-22 E. K. Papanova, N. M. Vorobyeva, Yu. V. Kotovskaya, O. N. Tkacheva, L. N. Ovcharova, E. V. Selezneva
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Effect on Physical Functions of Older Adults When Refraining from Going out due to COVID-19 Restrictions Adv. Gerontol. Pub Date : 2022-12-22 S. Suzumura, K. Ito, R. Narukawa, E. Takano, K. Satoh, T. Ueda, I. Kondo
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Multidisciplinary Approach in the Treatment of Elderly and Senile Patients with Complications of Colon Cancer Adv. Gerontol. Pub Date : 2022-12-22 N. I. Glushkov, A. M. Belyaev, T. L. Gorshenin, S. K. Dulaeva
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Neurological Aspects of Systemic Lupus Erythematosus in Individuals with Late Ontogenetic Debut Adv. Gerontol. Pub Date : 2022-12-22 V. I. Odin, E. A. Yurkina, A. K. Yurkin, M. M. Toporkov, G. I. Shvartsman, E. M. Pervova
Abstract The review presents the analysis of publications about the peculiarities of the manifestation of systemic lupus erythematosus (SLE) in individuals of older age groups. The probable reasons and mechanisms of the development of neurological manifestations of the disease are reflected in the work. The clinical pattern in elderly patients is described in detail and the peculiarities of immune
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Determinants of Subjective Loneliness and Quality of Life among Community-Dwelling Older Adults in Gorgan, Iran Adv. Gerontol. Pub Date : 2022-12-22 A. Kousha, E. Lotfalinezhad, H. Nadrian, D. Bhalla, M. Asghari-jafarabadi, A. Sohrabi, M. Hashemiparast, M. R. Honarvar
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Age-Related Menopause and Carbonyl Stress Adv. Gerontol. Pub Date : 2022-12-22 A. S. Brichagina, N. V. Semenova, L. I. Kolesnikova
Abstract The review analyzes the published data of some studies on redox homeostasis in women with age-related physiological menopause. Despite the ambiguity of the presented results on the oxidative modification of lipids, proteins, and carbohydrates, most studies allow us to consider this age period as one of the factors in the development of carbonyl stress, which is an integral part of aging. The
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Peculiarities of Venous Trophic Ulcers Course in Gerontoligical Patients according to Local Immunity and Morphological Manifestations Adv. Gerontol. Pub Date : 2022-12-22 H. A. Abduvosidov, S. M. Chudnikh, I. A. Chekmareva, I. G. Ostrovskaya, T. P. Vavilova, E. V. Kravchenko, Y. I. Korolova, I. L. Konorova
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COVID-19 in Lifespan: Psychological Impact between Young and Older Adults in Argentina Adv. Gerontol. Pub Date : 2022-12-22 M. J. García, H. López-Morales, M. V. del-Valle, L. Canet-Juric, S. Urquijo
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Effect of Physical Activity on Sleep Outcomes among Iranian Older Adults: A Cross-Sectional Study Adv. Gerontol. Pub Date : 2022-12-22 S. Aliabadi, F. Zarghami, A. Farhadi, F. Sharifi, M. Moodi
Abstract Sleep disorders have a significant impact on physical and mental health. This study was aimed to determine the effect of physical activity (PA) on sleep outcomes in older adults living in Birjand, Iran. This descriptive-analytical study was performed on 1740 individuals, ≥60 years in urban and rural regions of Birjand. The Longitudinal Ageing Study Amsterdam Physical Activity Questionnaire
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Survey of Knowledge, Attitudes and Practice of the Elderly toward COVID-19 Pandemic in Al-Amara, Iraq Adv. Gerontol. Pub Date : 2022-09-11 G. Al-Abedi
Abstract During the COVID-19 pandemic, elderly people (those aged 60 years and above) are more susceptible to coronavirus infection due to altered immune system response and a higher rate of underlying comorbidities. The purpose of present study was to identify of knowledge, attitudes and practices (KAP) of elderly people in Iraq toward COVID-19 disease as a vulnerable group and to found out relationship
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Involvement of Elderly People in the Processes of Modern Digital Transformations Adv. Gerontol. Pub Date : 2022-09-11 G. A. Barysheva, E. I. Klemasheva, O. P. Nedospasova, Tran Thi Bich Ngoc, Nguyen Chien Thang
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Relationship between Disease Avoidance and Attitudes toward Older People Adv. Gerontol. Pub Date : 2022-09-11 Y. Shimizu, T. Hashimoto, K. Karasawa
Abstract Negative attitudes toward older people persist, leading to the neglect and marginalization of older adults’ will. The social group of older people is often perceived as being overly associated with disease, and disease avoidance is related to negative attitudes. Meanwhile, people with higher disease avoidance tend to avoid others, not just older adults. Therefore, whether disease avoidance
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Accelerated Aging as a Risk of Education Digitalization: Possibilities for Prevention Adv. Gerontol. Pub Date : 2022-09-11 D. S. Lysenko, A. V. Lysenko, L. A. Sorokina, L. G. Buinov, A. V. Arutjunyan
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Transport and Possible Outcome of Lipofuscin in Mouse Myocardium Adv. Gerontol. Pub Date : 2022-09-11 L. Wang, C.-Y. Xiao, J.-H. Li, G.-C. Tang, S.-S. Xiao
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Telerehabilitation of Post-Stroke Patients with Motor Function Disorders: A Review Adv. Gerontol. Pub Date : 2022-09-11 V. A. Nikolaev, O. G. Safonicheva, A. A. Nikolaev
Abstract Stroke is the main reason for disabilities of increasing geriatric population. It affects brain and motor function domains significantly reducing the life quality. Recent coronavirus pandemic raised a question on changing approaches to deliver post-stroke rehabilitation services to geriatric patients due to their high risk of serious illness. This paper presents an overview of current telerehabilitation
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Gender and Age Related Macro- and Trace Minerals Estimation Survey among the European North Residents Adv. Gerontol. Pub Date : 2022-09-11 I. A. Vinogradova, D. V. Varganova, E. A. Lugovaya
Abstract A comparative analysis of the content of elements in hair of the residents of Karelia of different gender and age and of the deviation in the content from reference values typical for residents of the central part of the Russian Federation is carried out. Hair from the occipital part of the head, in which the content of 25 chemical elements is determined, are used as the biological object
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Ontogenetic Principles of Accelerated Aging and the Prospects for Its Prevention and Treatment Adv. Gerontol. Pub Date : 2022-09-11 V. N. Meshchaninov, P. B. Tsyvian, V. S. Myakotnykh, O. P. Kovtun, D. L. Shcherbakov, M. S. Blagodareva
Abstract This article examines the phenomenon of “intrauterine programming,” which largely determines the further life cycle and the likelihood of developing a number of age-associated pathological processes. The possibility of the formation of pathological (accelerated) aging at various stages of ontogenesis is discussed with the use of a large amount of published material from the standpoint of modern
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Intraoperative and Early Postoperative Risk Factors for the Development of Acute Cerebrovascular Accident in Elderly Patients after Coronary-Artery Bypass Grafting Adv. Gerontol. Pub Date : 2022-09-11 T. A. Shnitman, I. G. Trukhanova, S. V. Bulgakova, N. O. Zakharova
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Interrelation of MicroRNAs and Transposons in Aging and Carcinogenesis Adv. Gerontol. Pub Date : 2022-09-11 R. N. Mustafin
Abstract The dysregulation of transposable elements plays a key role in human carcinogenesis. Physiological aging in humans is also caused by the deregulation of transposons. Moreover, aging is associated with the development of cancer. We present the results of an analysis of data on the presence of common epigenetic changes during aging and carcinogenesis, associated with changes in the expression
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Peculiarities of the Innervation of Epicardial Adipose Tissue in a Rat with Aging (Immunohistochemical Study) Adv. Gerontol. Pub Date : 2022-09-11 E. I. Chumasov, E. S. Petrova, D. E. Korzhevskii
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Forecasting the Number of Grandparents in Russia under Conditions of Limited Information Resources Adv. Gerontol. Pub Date : 2022-09-11 O. M. Shubat, A. P. Bagirova
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Noninvasive Methods for Studying Skin with Different Morphotypes of Aging Adv. Gerontol. Pub Date : 2022-09-11 N. P. Teplyuk, S. V. Lebedeva
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Structure and Main Stages of Long-Term State Support to Elderly Citizens Adv. Gerontol. Pub Date : 2022-09-11 V. N. Anisimov, A. V. Finagentov, G. A. Bordovskiy, M. Yu. Kabanov
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Retirement Resources Inventory—Scale Assessment, Relationship to Retirement Satisfaction, Adjustment and a Meta-Analytical Review Adv. Gerontol. Pub Date : 2022-09-11 R. Hanák, L. Pitel
Abstract The Retirement Resources Inventory (RRI) created by C.S. Leung and L.K. Earl is a frequently used self-reported scale for measuring retirement resources. Since it was introduced, 10 scientific papers have been published using the full set of questions and 3 papers using only some of the questions. These have produced ambiguous and inconsistent results with considerable differences in almost
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Comparative Analysis of Quality of Life and Attachment Style among Cancer and Dementia Informal Caregivers Adv. Gerontol. Pub Date : 2022-07-12 N. Papageorgiou, A. Zygogianni, E. Parpa, E. Tsilika, K. Mystakidou
Abstract To record and compare the quality of life and attachment style of dementia and cancer caregivers. This is a comparative prospective cross sectional study. Participants were 45 caregivers of patients with cancer and 45 caregivers of patients with dementia. The study was conducted at a University Hospital and from a Day Centre of Alzheimer Disease and related disorders Association in Athens
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Abuse and Neglect of Community-Dwelling Older Adults: Index Generation, an Assessment of Intensity, and Implications for Ageing in Place Adv. Gerontol. Pub Date : 2022-07-12 N. Asiamah, A. K. Conduah, E. Danquah, K. Kouveliotis, R. Eduafo
Abstract Abuse and neglect of older adults in the community are a threat to aging in place programs. Recently, some researchers constructed the first scale for assessing elderly abuse and neglect in the neighborhood for research and routine monitoring. This study provides a protocol for generating an index from this tool and assessing the intensity of abuse and neglect. Implications for aging in place
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Leukocyte Telomere Length and Response to Antiangiogenic Therapy in Patients with Neovascular Age-Related Macular Degeneration Adv. Gerontol. Pub Date : 2022-07-12 A. Zh. Fursova, A. S. Derbeneva, M. S. Tarasov, I. F. Nikulich, V. A. Devyatkin, D. V. Telegina, N. G. Kolosova, O. S. Kozhevnikova
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Modern Approach and Geriatric Aspects of Teaching Gerontostomatology in Training Specialists under the Specialty Program Adv. Gerontol. Pub Date : 2022-07-12 A. K. Iordanishvili
Abstract The strategy of dental care for older age groups is based not only on the priorities determined by the demographic situation (guided by its development and the epidemiologically justified need for dental care), but also on improving the effectiveness of care, which must be based on the results of evidence-based medicine, as well as a personalized approach, implemented through the competencies
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Comparison of Older Primary Healthcare Workers with Non-Older Workers in Terms of Working Life, Quality of Life and Health Problems in Turkey Adv. Gerontol. Pub Date : 2022-07-12 V. Akkaya, M. Picakciefe, M. N. Ilhan
Abstract With the rapid growth of aging all over the world, it was reported that the proportion of older workers in employment would increase. It was aimed to comparison of older primary healthcare workers with non-older workers in terms of working life, quality of life and health problems in Mugla, Turkey. This cross-sectional was conducted in primary healthcare workers in Mugla. In the study population
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Perceptions of Caregiving by Family Caregivers of Older Adults with Dementia in Iran: A Qualitative Study Adv. Gerontol. Pub Date : 2022-07-12 A. Farhadi, F. Mohammadi-Shahboulaghi, M. Rassouli, L. Sadeghmoghadam, S. Nazari, M. Froughan
Abstract The concept of caring appraisal, which includes positive and negative aspects of care, has been considered as one of the key concepts in caregivers’ studies and is affected by the knowledge, attitudes, values, beliefs, and social norms in their society. In this respect, the perception of family caregivers’ can be studied from a cultural perspective. The aim of the present study was to explore
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Astragalus membranaceus Increases Leukocyte Telomere Length, but Does Not Suppress Development of Accelerated Senescence Signs in OXYS Rats Adv. Gerontol. Pub Date : 2022-07-12 O. S. Kozhevnikova, V. A. Devyatkin, M. A. Tyumentsev, E. A. Rudnitskaya, A. Zh. Fursova, N. G. Kolosova
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Changes in the Number of p23-Positive Fibroblasts in Human Dermis with Aging Adv. Gerontol. Pub Date : 2022-07-12 A. G. Gunin, N. N. Golubtzova
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Experimental Studies of Geroprotective and Anti-Aging Effects of Chemical Compounds of Portulaca oleracea L. (Review) Adv. Gerontol. Pub Date : 2022-07-12 M. A. Berezutsky, N. A. Durnova, A. S. Sheremetyewa, U. A. Matvienko, M. N. Kurchatova
Abstract The analysis presented in the review of publications shows that extract of Portulaca oleracea L. or its individual components (polysaccharides, oleracea, alkaloids tetrahydroisoquinoline operatein E) is able to increase the lifespan of laboratory animals, to activate telomerase and increase telomere length, and to provide antioxidant and antiosteoclastogenic impact. Various neuroprotective
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Ageist Attitudes: Youth Identity, Subjective Time to Become Older, and Impressions of the General Older Population’s Physical and Mental Health Adv. Gerontol. Pub Date : 2022-07-12 Y. Shimizu, T. Hashimoto, K. Karasawa
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Age-Associated Features of the Expression Level of Apoptosis Markers in Cardiomyocytes of Patients with Dilated Cardiomyopathy Adv. Gerontol. Pub Date : 2022-07-12 K. P. Kravchenko, K. L. Kozlov, A. O. Drobintseva, D. S. Medvedev, V. O. Polyakova
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Piezopulsometric Analysis of Autonomous Regulation of the Cardiovascular System in an Elderly Person under Stress Adv. Gerontol. Pub Date : 2022-07-12 V. P. Nesterov, A. I. Burdygin, K. B. Ivanov, S. V. Nesterov, S. I. Soroko
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AEDG Peptide Prevents Oxidative Stress in the Model of Induced Aging of Skin Fibroblasts Adv. Gerontol. Pub Date : 2022-07-12 E. O. Gutop, N. S. Linkova, E. O. Kozhevnikova, N. V. Fridman, O. M. Ivko, V. Kh. Khavinson
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Morphological Signs of Neurogenic Inflammation in the Heart of Rats during Aging Adv. Gerontol. Pub Date : 2022-07-12 E. I. Chumasov, E. S. Petrova, D. E. Korzhevskii