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The time-effect relationship between time to surgery and in-hospital postoperative pneumonia (IHPOP) in older patients with hip fracture. Gerontology (IF 3.5) Pub Date : 2023-11-26 Xinqun Cheng,Song Liu,Jincheng Yan,Lin Wang,Xiang Lei,Haifeng Wu,Yanbin Zhu,Yingze Zhang
INTRODUCTION Pneumonia is a common and devastating complication following hip fracture surgery in older patients. Time to surgery is a potentially modifiable factor associated with improved prognosis, and we aim to quantify the time-effect relationship between time to surgery and in-hospital postoperative pneumonia (IHPOP) and identify the effect of delayed surgery on the risk of IHPOP. METHODS We
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Exercise Regulates Myokines on Aging-related Diseases through Muscle-brain Crosstalk. Gerontology (IF 3.5) Pub Date : 2023-11-24 Bingqing Wang,Jiling Liang,Chen Lu,Aming Lu,Cenyi Wang
BACKGROUND The related functions of skeletal muscle and brain decrease significantly with age, and muscle-brain-related diseases are primarily associated with each other. Exercise can promote the secretion of myokines in skeletal muscle, showing a beneficial effect on the function of both, reflecting muscle-brain crosstalk. However, the key mechanism of action of exercise-regulated myokines in muscle-brain
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'What's the most important to them?' Swiss health care proxies, nurses and physicians discuss planning practices for aged care residents who no longer have medical decision-making capacity. Gerontology (IF 3.5) Pub Date : 2023-11-24 Laura Jones,Florent Rhyner,Rachel Rutz Voumard,Fiorella Figari Aguilar,Eve Rubli Truchard,Ralf J Jox
INTRODUCTION Multiple morbidities, including neurodegenerative diseases such as dementia, which result in diminished decision-making capacity, make care and care planning complicated for Residential Aged Care Facility (RACF) residents. While Advance Care Planning (ACP) has been highlighted as essential for ensuring that this population receive care that is coherent with their wishes, there are few
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Testing a conceptual model of physiologic reserve, intrinsic capacity, and physical resilience in hospitalized older patients: A structural equation modelling. Gerontology (IF 3.5) Pub Date : 2023-11-23 Fang-Wen Hu,Fang-Ru Yueh,Tzu-Jung Fang,Chia-Ming Chang,Chung-Ying Lin
INTRODUCTION The relationship among physiologic reserve, intrinsic capacity, and physical resilience has not been examined, and a conceptual model that includes these key determinants of healthy ageing is needed. This study aimed to test a conceptual model using real-world data to determine the relationships among physiologic reserve, intrinsic capacity, physical resilience, and clinical outcomes.
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Monitoring gait and physical activity of elderly frail individuals in free-living environment: a feasibility study. Gerontology (IF 3.5) Pub Date : 2023-11-20 Nunzio Camerlingo,Nina Shaafi Kabiri,Dimitrios J Psaltos,Meredith Kelly,Madisen K Wicker,Isabelle Messina,Sanford H Auerbach,Hao Zhang,Andrew Messere,Fikret Isik Karahanoglu,Mar Santamaria,Charmaine Demanuele,David Caouette,Kevin C Thomas
INTRODUCTION Frailty is conventionally diagnosed using clinical tests and self-reported assessments. However, digital health technologies (DHTs), such as wearable accelerometers, can capture physical activity and gait during daily life, enabling more objective assessments. In this study, we assess the feasibility of deploying DHTs in community-dwelling older individuals, and investigate the relationship
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Cardiovascular Disease Risk Scores and Incident Dementia and Cognitive Decline in Older Men and Women. Gerontology (IF 3.5) Pub Date : 2023-11-20 Swarna Vishwanath,Ingrid Hopper,Enayet Chowdhury,Rory Wolfe,Rosanne Freak-Poli,Christopher M Reid,Andrew M Tonkin,Anne M Murray,Raj C Shah,Trevor T-J Chong,Robyn L Woods,John McNeil,Suzanne G Orchard,Mark R Nelson,Claire J Steves,Joanne Ryan
INTRODUCTION Risk factors for cardiovascular disease (CVD) also increase the risk of dementia. However, whether commonly used CVD risk scores are associated with dementia risk in older adults who do not have a history of CVD, and potential gender differences in this association, remains unclear. The aim of this study was to determine whether CVD risk scores are prospectively associated with cognitive
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Association between F2-isoprostane metabolites and weight change in older women: a longitudinal analysis. Gerontology (IF 3.5) Pub Date : 2023-11-15 Yingya Zhao,Marina S Nogueira,Qingxia Chen,Qi Dai,Qiuyin Cai,Wanqing Wen,Qing Lan,Nathaniel Rothman,Yu-Tang Gao,Xiao-Ou Shu,Wei Zheng,Ginger L Milne,Gong Yang
INTRODUCTION Theoretically, some metabolic traits may predispose older individuals to weight loss during aging, leading to increased all-cause mortality and many serious health issues. Biomarkers to robustly predict progressive weight loss during aging are, however, lacking. We prospectively assessed if urinary levels of F2-isoprostanes and their peroxisomal -oxidation metabolite, 2,3-dinor-5,6-d
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Dose-response relationship between C-reactive protein/albumin ratio and in-hospital mortality in elderly patients with acute ischemic stroke. Gerontology (IF 3.5) Pub Date : 2023-11-10 Mingquan Li,Yan Chen,Zhibin Chen,Liumin Wang,Wen Xie,Yanli Zhang,Lina Wang,Ling Liu,Hui Zhao,Pingmin Wei
INTRODUCTION The C-reactive protein/albumin ratio is a reliable indicator of outcome risk in several diseases. This study aims to evaluate prognostic power of the C-reactive protein/albumin ratio for in-hospital mortality and the dose-response relationship between the two in the oldest-old patients with acute ischemic stroke. METHODS A longitudinal observational study was conducted including patients
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Sitagliptin Extends Lifespan of Caenorhabditis elegans by Inhibiting IIS and Activating DR-like Signaling Pathways. Gerontology (IF 3.5) Pub Date : 2023-11-10 Qunshan Ye,Yimin Li,Cheng Wang,Jingming Zheng,Jing Qiao,Jing Yang,Qin-Li Wan
INTRODUCTION The discovery of longevity molecules that delay aging and prolong lifespan has always been a dream of humanity. Sitagliptin phosphate (SIT), an oral dipeptidyl peptidase-4 (DPP-4) inhibitor, is an oral drug commonly used in the treatment of type 2 diabetes (T2D). In addition to being anti-diabetic, previous studies have reported that SIT has shown potential to improve health. However,
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The Potential Predicting Value of D-dimer to Fibrinogen Ratio on Functional Outcome at 1 year after Acute Ischemic Stroke:A longitudinal study. Gerontology (IF 3.5) Pub Date : 2023-11-03 Qingxia Lin,Dongdong Zhou,Yifan Cheng,Chunxue Wu,Binbin Deng
Previous studies have suggested that the D-dimer to fibrinogen ratio (DD/Fg) could be a potential predictor for deep vein thrombosis, pulmonary embolism, and stroke severity. However, the association between plasma DD/Fg and functional outcome following acute ischemic stroke (AIS) has been unclear. Our study followed the STROBE guideline and used a prospective cohort design to investigate this association
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Synergistic Impact of Visual and Cognitive Impairments on Health-related Quality of Life in a Multi-Ethnic Asian Population. Gerontology (IF 3.5) Pub Date : 2023-10-30 Tai Anh Vu,Preeti Gupta,Alfred Tl Gan,Eva K Fenwick,Ryan Ek Man,Charumathi Sabanayagam,Ching-Yu Cheng,Ecosse L Lamoureux
INTRODUCTION The concomitant impact of visual impairment (VI) and cognitive impairment (CI) on health-related quality of life (HRQoL) in older adults is unclear. We aimed to determine the synergistic effect of baseline VI and CI on HRQoL decline at 6 years in multiethnic Asians. METHODS We included Chinese, Malay, and Indian adults aged ≥60 years who participated in baseline (2004-2011) and 6-year
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Association of physical frailty and cognitive function in a population-based cross-sectional study of American older adults. Gerontology (IF 3.5) Pub Date : 2023-10-30 Shama Karanth,Dejana Braithwaite,Yuriko Katsumata,Ranjan Duara,Paul Norrod,Ikramuddin Aukhil,Erin L Abner
INTRODUCTION Cognitive impairment and frailty are prevalent in older persons. Physical frailty is associated with cognitive decline; however, the role of effect modifiers such as age, sex, race/ ethnicity, and cognitive reserve is not well understood. METHODS Cross-sectional data from the National Health and Nutrition Examination Survey (2011-2014) were obtained for participants aged ≥ 60 years. Complete
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Dietary Patterns and Healthy or Unhealthy Aging. Gerontology (IF 3.5) Pub Date : 2023-10-26 Ligia J Dominguez,Nicola Veronese,Mario Barbagallo
BACKGROUND The aging process is complex comprising various contributing factors influencing late life conditions and eventual occurrence of chronic diseases that generate high financial and human costs. These factors include genetic proneness, lifestyle conducted throughout life, environmental conditions, as well as dietary aspects, among others, all together modulating precise pathways linked to aging
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Gut microbe-metabolite profiles are associated with microbial pathways of longevity in women: a cross-sectional study conducted in China. Gerontology (IF 3.5) Pub Date : 2023-10-26 Qinren Zhang,Ning Meng,Ruiding Li,Qianzu He,Xiaolin Liang,Fan Zhou,Wenxuan Zheng,Jinke Ma,Xiaohan Yu,Kaiyan Tan,Quanyang Li
INTRODUCTION Recent research on the gut deepens people's understanding of the role of gut microbe-metabolites in longevity. However, most of the longevity population is female, and the gut microbe-metabolites associated with longevity in women remain unknown. Here, we hypothesize that the gut microbe-metabolite levels differed between the longevity women (LW, age ≥ 90) and the elderly women (EW, 60
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Cellular Senescence in Human Skin Aging: Leveraging Senotherapeutics. Gerontology (IF 3.5) Pub Date : 2023-10-25 Saranya P Wyles,Jean D Carruthers,Parisa Dashti,Grace Yu,Jane Q Yap,Anne Gingery,Tamara Tchkonia,James Kirkland
As the largest organ in the human body, skin is continuously exposed to intrinsic and extrinsic stimuli that impact its functionality and morphology with aging. Skin aging entails dysregulation of skin cells and loss, fragmentation, or fragility of extracellular matrix fibers that are manifested macroscopically by wrinkling, laxity, and pigmentary abnormalities. Age-related skin changes are the focus
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Impact of a COVID-19 related Lockdown on the Experience of Informal Caregiving in Singapore. Gerontology (IF 3.5) Pub Date : 2023-10-21 Vicky Mengqi Qin,Abhijit Visaria,Rahul Malhotra
INTRODUCTION Lockdowns, while limiting COVID-19 transmission, can affect provision of care by informal caregivers and their caregiving experience. We assessed, among informal caregivers in Singapore, a) the perceived impact of a two-month (April to May 2020) nationwide lockdown on their care provision, b) correlates of different perceptions of the impact of the lockdown on care provision, and c) association
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Telomere length among Chinese aged 75+ years. Gerontology (IF 3.5) Pub Date : 2023-10-19 Suey S Y Yeung,Suk Ling Ma,Xingyan Wang,Yangchao Chen,Stephen Kwok Wing Tsui,Nelson Leung Sang Tang,Jean Woo
INTRODUCTION Telomere length (TL) is generally regarded as a biomarker of aging. TL, which is influenced by sociodemographic factors, has been shown to be inversely associated with morbidity. However, most studies examined the youngest old and whether the findings can be extended to older individuals is less clear. Further, few studies have examined these questions in Chinese older adults. This cross-sectional
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Dynamic Prognostic Score to Predict Survival in East Asian Elderly Populations with Dysphagia. Gerontology (IF 3.5) Pub Date : 2023-10-13 Jiao Wang,Shuying Huang,Lianghua Huang,Yunliang Tang
INTRODUCTION Dysphagia is a common disorder in older adults leading to severe complications, including aspiration pneumonia, dehydration, malnutrition, weight loss, and even death. However, no prognostic model has been developed to predict the prognosis of older adults with dysphagia. METHODS Data from patients with dysphagia at a single center were retrospectively reviewed between 2014 and 2017. All
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Is the pentagon-copying task more than a cognitive feature? Associations with handgrip strength, gait speed and frailty in older adults. Gerontology (IF 3.5) Pub Date : 2023-10-13 Alberto Sardella,Federica Bellone,Giuseppe Mandraffino,Fabio Malacarne,Giuseppe Maltese,Giovanni Squadrito,Maria C Quattropani,Giorgio Basile
BACKGROUND The pentagon copy is a sensitive item to the prediction of cognitive decline and dementia. Cognitive and physical/motor decline are able to accelerate the evolution of each other, by representing a common pathway towards frailty. OBJECTIVES To investigate the association of the pentagon-copying task with physical and motor performances and with frailty, in a sample of older adults. METHOD
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Targeting cartilage miR-195/497 cluster for osteoarthritis treatment regulates the circadian clock. Gerontology (IF 3.5) Pub Date : 2023-10-12 Shi Shi,Lele Zhang,Qi Wang,Qian Wang,Dejian Li,Wei Sun,Chengqing Yi
INTRODUCTION Osteoarthritis (OA) is the most prevalent and debilitating joint disease without an effective therapeutic option. Multiple risk factors for OA have been identified, including abnormal chondrocyte miRNA secretion and circadian rhythms disruption, both of which have been found to cause progressive damage and loss of articular cartilage. Environmental disruption of circadian rhythms in mice
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Changes in network size, quality and composition among informal caregivers in different welfare clusters: Longitudinal analyses based on pan-European survey (SHARE). Gerontology (IF 3.5) Pub Date : 2023-10-09 Larissa Zwar,Hans-Helmut König,André Hajek
INTRODUCTION This study analyzed the association between transitions into informal caregiving, inside and outside their own household, and changes in network size, quality and composition among older adults (≥50 years) in four different welfare systems in Europe. METHODS Data from wave 4, 6 and 8 of the Survey of Health, Ageing and Retirement in Europe was used and included up to 110,823 participants
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Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain. Gerontology (IF 3.5) Pub Date : 2023-10-04 Elif Tugce Karoglu-Eravsar,Melek Umay Tuz-Sasik,Aysenur Karaduman,Ayse Gokce Keskus,Ayca Arslan-Ergul,Ozlen Konu,Hulusi Kafaligonul,Michelle M Adams
INTRODUCTION Interventions targeting cholinergic neurotransmission like acetylcholinesterase (AChE) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. However, the chronic effects of these interventions are not well-described. METHODS In the current study, global levels of cholinergic, cellular, synaptic, and i
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Relationship between the ratio of red cell distribution width to albumin and 28-day mortality among Chinese patients over 80 years with atrial fibrillation. Gerontology (IF 3.5) Pub Date : 2023-10-04 Conggai Chen,Jiasheng Cai,Bin Song,Lingyun Zhang,Wei Wang,Rong Luo,Yi Zhang,Yunhao Ling,Chuntao Wu,Zilong Wang,Haibo Liu,Yumei Wu,Xinkai Qu
INTRODUCTION Atrial fibrillation (AF) is a prevalent heart arrhythmia in elderly adults aged 80 years or older. The red cell distribution width to albumin ratio has been acknowledged as a reliable prognostic marker for poor outcomes in a variety of disorders. However, there exists limited scientific evidence on the association of red cell distribution width to albumin (RAR) with mortality in geriatric
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Explaining variation in individual aging, its sources, and consequences: A comprehensive conceptual model of human aging. Gerontology (IF 3.5) Pub Date : 2023-09-28 Klaus Rothermund,Christoph Englert,Denis Gerstorf
We define aging as a characteristic deterioration in one (or more) observable attributes of an organism that typically occurs during later life. With this narrow functional definition, we gain the freedom to separate aging from other processes of age-related change (e.g., maturation, growth, illness, terminal decline). We introduce a structural model that distinguishes between (a) the phenomenon of
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Is frailty different in younger adults compared to old? Prevalence, characteristics and risk factors of early-life and late-life frailty in samples from Sweden and UK. Gerontology (IF 3.5) Pub Date : 2023-09-28 Ge Bai,Yunzhang Wang,Jonathan K L Mak,Malin Ericsson,Sara Hägg,Juulia Jylhävä
Introduction Although frailty is commonly considered as a syndrome of old individuals, recent studies show that it can affect younger adults, too. Whether and how frailty differs in younger adults compared to old is however unknown. To this end, we analyzed the prevalence, characteristics, and risk factors of early-life (aged <65) and late-life (aged ≥65) frailty. Methods We analyzed individuals in
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Age-Related Gene and Protein Expression in Mouse Mandibular Condyle Analyzed by Cap Analysis of Gene Expression and Immunohistochemistry. Gerontology (IF 3.5) Pub Date : 2023-09-28 Mu-Chen Yang,Megumi Nakamura,Yoko Kageyama,Yohei Igari,Yasuyuki Sasano
INTRODUCTION Aging, an inevitable physiological process, leads to morphological and histological degenerative changes in the mandibular condylar cartilage (MCC); however, the molecular mechanism has not yet been elucidated, and little information is available on age-related factors. Therefore, this study was designed to identify age-related factors by investigating the age-related differentially expressed
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Associations between differential aging and lifestyle, environment, current, and future health conditions: Findings from Canadian Longitudinal Study on Aging. Gerontology (IF 3.5) Pub Date : 2023-09-19 Yipeng Song,Yang S Liu,Fernanda Talarico,Yanbo Zhang,Jake Hayward,Mengzhe Wang,Eleni Stroulia,Roger A Dixon,Russell Greiner,Xinmin Li,Andrew Greenshaw,Sui Jie,Bo Cao
INTRODUCTION An aging population is a pressing challenge for the healthcare system. Insights into promoting healthy longevity can be gained by quantifying the biological aging process and understanding the roles of modifiable lifestyle and environmental factors and chronic disease conditions. METHODS We developed a biological age (BioAge) index by applying multiple state-of-art machine learning models
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Early-Life Factors and Multimorbidity Risk Later in Older Age: Evidence Based on CHARLS. Gerontology (IF 3.5) Pub Date : 2023-09-19 Minjun Zhao,Xu He,Tianrong Li,Heng Shao,Qian Huo,Yan Li
INTRODUCTION Early-life factors were reported to exert influence on the health condition of individuals in the long-term. However, limited research explored the connection between early-life factors and multimorbidity in later years. METHODS We utilized the data from the China Health and Retirement Longitudinal Study to assess this possible association in the present cross-sectional study. Multimorbidity
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Application of Multiple Omics to Understand Postoperative Delirium Pathophysiology in Humans. Gerontology (IF 3.5) Pub Date : 2023-09-18 Sarinnapha M Vasunilashorn,Simon T Dillon,Edward R Marcantonio,Towia A Libermann
Delirium, an acute change in cognition, is common, morbid, and costly, particularly among hospitalized older adults. Despite growing knowledge of its epidemiology, far less is known about delirium pathophysiology. Initial work understanding delirium pathogenesis has focused on assaying single or a limited subset of molecules or genetic loci. Recent technological advances at the forefront of biomarker
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The Mediating Role of Affective States in Short-Term Effects of Activity Engagement on Working Memory in Older Age. Gerontology (IF 3.5) Pub Date : 2023-09-18 Minxia Luo,Robert Glenn Moulder,Elisa Weber,Christina Röcke
INTRODUCTION It has been shown that activity engagement is associated with cognitive ability in older age, but mechanisms behind the associations have rarely been examined. Following a recent study which showed short-term effects of activity engagement on working memory performance appearing 6 hours later, this study examined the mediating role of affective states in this process. METHODS For seven
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Spatial Transcriptomics of Aging Rat Ovaries Reveals Unexplored Cell Subpopulations with Reduced Antioxidative Defense. Gerontology (IF 3.5) Pub Date : 2023-09-16 Jiayu Shen,Yuanyuan Liu,Xinyuan Teng,Ligui Jin,Lin Feng,Xiwen Sun,Fengdong Zhao,Bao Huang,Jinjie Zhong,Yingying Chen,Liquan Wang
INTRODUCTION Ovarian aging is characterized by a gradual decline in quantity and quality of oocytes and lower chance of fertility. Better understanding the genetic modulation during ovarian aging can further address available treatment options for aging-related ovarian diseases and fertility preservation. METHODS A novel technique spatial transcriptomics (ST) was used to investigate the spatial transcriptome
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Impact of 14 Days of Bed Rest in Older Adults and an Exercise Countermeasure on Body Composition, Muscle Strength, and Cardiovascular Function: Canadian Space Agency Standard Measures. Gerontology (IF 3.5) Pub Date : 2023-09-15 Guy Hajj-Boutros,Vita Sonjak,Andréa Faust,Eric Hedge,Carmelo Mastrandrea,Jean-Christophe Lagacé,Philippe St-Martin,Donya Naz Divsalar,Farshid Sadeghian,Stéphanie Chevalier,Teresa Liu-Ambrose,Andrew P Blaber,Isabelle J Dionne,Simon Duchesne,Richard Hughson,Saija Kontulainen,Olga Theou,José A Morais
INTRODUCTION Head-down bed rest (HDBR) has long been used as an analog to microgravity, and it also enables studying the changes occurring with aging. Exercise is the most effective countermeasure for the deleterious effects of inactivity. The aim of this study was to investigate the efficacy of an exercise countermeasure in healthy older participants on attenuating musculoskeletal deconditioning,
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Relationship between VO2peak, VO2 Recovery Kinetics, and Muscle Function in Older Adults. Gerontology (IF 3.5) Pub Date : 2023-09-01 Rhiannon D Healy,Cassandra Smith,Mary N Woessner,Itamar Levinger
INTRODUCTION The efficiency of the cardiovascular system to recover following an exercise bout is measured by oxygen (VO2) recovery kinetics. In older adults with a chronic disease, a higher aerobic capacity (VO2peak) and faster VO2 recovery kinetics are associated with higher muscle strength and physical capacity. Yet, this relationship in healthy older adults remains unclear. The aim of this cross-sectional
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Isolated Minimally Invasive Mitral Valve Surgery in Octogenarians: Perioperative Outcome. Gerontology (IF 3.5) Pub Date : 2023-08-30 Vasileios Ntinopoulos,Hector Rodriguez Cetina Biefer,Nestoras Papadopoulos,Stak Dushaj,Achim Haeussler,Omer Dzemali
INTRODUCTION Despite the feasibility, safety, and excellent outcomes of mitral valve surgery through a right mini-thoracotomy, there is data paucity about its use in octogenarians. In this study, we assess the outcomes of mitral valve surgery via right mini-thoracotomy in octogenarians. METHODS We performed a retrospective analysis of the in-hospital perioperative data of 38 octogenarian patients with
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The Healthy Ageing Questionnaire Index: Validation in the Singapore Longitudinal Ageing Study. Gerontology (IF 3.5) Pub Date : 2023-08-28 Tze Pin Ng,Xinyi Gwee,Denise Q L Chua,Shiou Liang Wee,Chin Yee Cheong,Philip Lin Kiat Yap,Keng Bee Yap
INTRODUCTION Healthy ageing (HA) indices typically use full questionnaire, performance- or blood-based assessment of functional ability which are time-consuming and resource-intensive. We developed and validated a simple and brief Healthy Ageing Questionnaire (HAQ) index with comparable measurement accuracy. METHODS The 15-item HAQ (scored 0-100) was developed using data of 500 participants in the
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Association between Low Blood Pressure and Subsequent Risk of Parkinson's Disease in Older Adults Aged ≥75 Years. Gerontology (IF 3.5) Pub Date : 2023-08-28 Ja Young Choi,Kyungdo Han,Yong Wook Kim,Sang Chul Lee,Jaeyong Shin,Seung Nam Yang,Seo Yeon Yoon
INTRODUCTION The association between blood pressure (BP) and incidence of Parkinson's disease (PD) in older adults remains uncertain. Therefore, this study aimed to investigate the association between BP (high or low) and PD incidence in adults aged ≥75 years. METHODS In this nationwide population-based cohort study, we enrolled participants aged ≥75 years without a prior PD diagnosis who had undergone
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Evaluating the Clinical Significance of Diazepam Binding Inhibitor in Alzheimer's Disease: A Comparison with Inflammatory, Oxidative, and Neurodegenerative Biomarkers. Gerontology (IF 3.5) Pub Date : 2023-08-22 Mustafa Gokce,Halil Aziz Velioglu,Muhammed Yunus Bektay,Eray Metin Guler
INTRODUCTION Alzheimer's disease (AD) is one of the pathologies that the scientific world is still desperate for. The aim of this study was the investigation of diazepam binding inhibitor (DBI) as a prognostic factor for AD prognosis. METHODS A total of 120 participants were divided into 3 groups. Forty new diagnosed Alzheimer patients (NDG) who have been diagnosed but have not started AD treatment
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Identification and Validation of an Aging-Associated circRNA-miRNA-mRNA Network in Neovascular Age-Related Macular Degeneration. Gerontology (IF 3.5) Pub Date : 2023-08-21 Jiali Wu,Yuxin Jiang,Junran Sun,Xiaodong Sun
INTRODUCTION Neovascular age-related macular degeneration (NVAMD) is a leading cause of severe vision impairment in the elderly. Aging is one of the most pivotal underlying molecular mechanisms of NVAMD. METHODS In this study, we identified the potential aging-related genes involved in NVAMD. Considering that noncoding RNAs are vital regulators of NVAMD progression, we further explored and constructed
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Daily Affect and Daily Prospective Memory in People after Stroke and Their Partners: The Moderating Role of Resting Heart Rate. Gerontology (IF 3.5) Pub Date : 2023-08-21 Minxia Luo,Theresa Pauly,Tiana Broen,Maureen C Ashe,Rachel A Murphy,Wolfgang Linden,Kenneth M Madden,Denis Gerstorf,Christiane A Hoppmann
INTRODUCTION Experimental research suggests that affect may influence prospective memory performance, but real-life evidence on affect-prospective memory associations is limited. Moreover, most studies have examined the valence dimension of affect in understanding the influence of affect on cognitive performance in daily life, with insufficient consideration of the arousal dimension. To maximize ecological
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Driving Automation for Older Adults with Preclinical Alzheimer's Disease. Gerontology (IF 3.5) Pub Date : 2023-08-09 Pedram Ahmadnezhad,Jeffrey M Burns,Abiodun E Akinwuntan,Maud Ranchet,Alexandra Kondyli,Jonathan D Mahnken,Hannes Devos
INTRODUCTION Older adults with preclinical Alzheimer's disease (AD) show changes in on-road driving performance. The impact of preclinical AD on using automated vehicle (AV) technology is unknown. The aim was to evaluate safety and cognitive workload while operating AV technology in drivers with preclinical AD. INTRODUCTION This cross-sectional study included 40 participants: 19 older adults (age 74
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Efficacy of Blue LED Phototherapy on Sleep Quality and Behavioral and Psychological Symptoms of Dementia: A Double-Blind Randomized Controlled Trial. Gerontology (IF 3.5) Pub Date : 2023-08-01 Ying-Ren Chen,Wen-Yu Huang,Tso-Ying Lee,Hsin Chu,Kai-Jo Chiang,Hsiu-Ju Jen,Doresses Liu,Ruey Chen,Xiao Linda Kang,Yueh-Jung Lai,Kuei-Ru Chou
INTRODUCTION People with dementia often experience behavioral and psychological symptoms of dementia (BPSD), which are a major cause of caregiver burden and institutionalization. Therefore, we conducted a double-blind, parallel-group randomized controlled trial to examine the efficacy of blue-enriched light therapy for BPSD in institutionalized older adults with dementia. METHODS Participants were
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Relationship between Total Kihon Checklist Score and Age-Specific Deaths among Late-Stage Older Adults in Otawara City (Aged 75 and Older) over a 15-Year Period. Gerontology (IF 3.5) Pub Date : 2023-07-26 Akihiro Ito,Tatsuya Igawa,Masahiro Ishizaka,Naori Hashimoto,Tsuyoshi Hara
INTRODUCTION While the Japanese long-term care insurance system supports an ageing society, there are concerns about the shortage of financial resources and labour force. Further, extending healthy life expectancy and narrowing the gap with the average life expectancy are important issues. In this study, we aimed to examine, over a 15-year period, the relationship between the total Kihon Checklist
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Association between Mobile Phone Use and Incidence of Dementia: A Prospective Cohort Study Using the UK Biobank. Gerontology (IF 3.5) Pub Date : 2023-07-26 Houyu Zhao,Qiaorui Wen,Lin Zhuo,Shengfeng Wang,Siyan Zhan
INTRODUCTION The rapid growth in mobile phone use has led to public concern about its potential effects on the risk of dementia. This study aimed to investigate the association between mobile phone use in daily life and the risk of dementia incidence in community-dwelling adults based on the data from the UK Biobank. METHODS Participants in the UK Biobank aged 60 years or older with no diagnosis of
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Effects of Testosterone Replacement Therapy on Muscle Strength in Older Men with Low to Low-Normal Testosterone Levels: A Systematic Review and Meta-Analysis. Gerontology (IF 3.5) Pub Date : 2023-07-26 Ta-Wei Lee,Pei-Yu Kao,Yang-Ching Chen,Sen-Te Wang
BACKGROUND Previous studies and meta-analyses have explored the relationship among testosterone, muscle strength, and physical function, to the best of our knowledge, no meta-analysis has investigated the effects of testosterone replacement therapy (TRT) on subgroup of relatively hypogonadal older men. OBJECTIVE The aim of this study was to evaluate the effect of TRT in older men with low testosterone
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Acacetin Alleviates Cardiac Fibrosis via TGF-β1/Smad and AKT/mTOR Signal Pathways in Spontaneous Hypertensive Rats. Gerontology (IF 3.5) Pub Date : 2023-06-22 Zhi-Yi Li,Si Lv,Jie Qiao,Si-Qi Wang,Fang Ji,Dan Li,Jie Yan,Yan Wei,Lin Wu,Changzhen Gao,Miao-Ling Li
INTRODUCTION Attenuating cardiac fibroblasts activation contributes to reducing excessive extracellular matrix deposition and cardiac structural remodeling in hypertensive hearts. Acacetin plays a protective role in doxorubicin-induced cardiomyopathy and ischemia/reperfusion injury. The aim of this study was to investigate the potential molecular mechanisms underlying the protective role of acacetin
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Novel Phenylethanoid Glycosides Improve Hippocampal Synaptic Plasticity via the Cyclic Adenosine Monophosphate-CREB-Brain-Derived Neurotrophic Growth Factor Pathway in APP/PS1 Transgenic Mice. Gerontology (IF 3.5) Pub Date : 2023-06-07 Shiliang Ji,Yijie Wu,Ruifang Zhu,Dongkai Guo,Yiguo Jiang,Lifeng Huang,Xinwei Ma,Liqiang Yu
INTRODUCTION Alzheimer's disease (AD) is a major public health concern worldwide, but there are still no drugs available that treat it effectively. Previous studies have shown that phenylethanoid glycosides have pharmacological effects, which include anti-AD properties, but the underlying mechanisms by which they ameliorate AD symptoms remain unknown. METHODS In this study, we used an APP/PS1 AD mouse
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Risk Factors of Progression to Cognitive Frailty: Singapore Longitudinal Ageing Study 2. Gerontology (IF 3.5) Pub Date : 2023-06-07 Shuen Yee Lee,Ma Shwe Zin Nyunt,Qi Gao,Xinyi Gwee,Denise Qian Ling Chua,Keng Bee Yap,Shiou Liang Wee,Tze Pin Ng
INTRODUCTION Cognitive frailty is associated with higher risk of dementia and adverse health outcomes. However, multidimensional factors that influence cognitive frailty transitions are not known. We aimed to investigate risk factors of incident cognitive frailty. METHODS Prospective cohort study participants were community-dwelling adults without dementia and other degenerative disorders and baseline
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Cognitive Activities, Lifestyle Factors, and Risk of Cognitive Impairment, with an Analysis of the Apolipoprotein Epsilon 4 Genotype. Gerontology (IF 3.5) Pub Date : 2023-06-05 Yuying Sun,Zhihui Wang,Shengzhi Sun,Lu Cui,Xiaoquan Zhu,Sai Yin Ho,Shige Qi
INTRODUCTION Cognitive stimulating activities and a healthy lifestyle are associated with less cognitive impairment. However, whether the association is varied by Apolipoprotein epsilon 4 (APOE ε4) allele carrier status remains inconclusive. We aimed to investigate whether the association of cognitively stimulating activities and a healthy lifestyle with the risk of cognitive impairment varied by APOE
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Sex Differences and Positive Dose-Response Relationships between Serum Osteocalcin Levels and Low Muscle Strength. Gerontology (IF 3.5) Pub Date : 2023-06-05 Pei-Yun Chen,Yi-Hsuan Lee,Chien-Hsieh Chiang,Hao-Hsiang Chang,Chia-Wen Lu,Kuo-Chin Huang
INTRODUCTION Impaired handgrip strength is an indication for sarcopenia and frailty screening, and is associated with increased osteoporotic risks and all-cause mortality. Osteocalcin, secreted by osteoblasts, is a versatile factor that participates in bone turnover and muscle adaptation. The role of osteocalcin in muscle strength has mainly been discussed in animal models and requires more human data
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Comparison between Two Different Handgrip Systems and Protocols on Force Reduction in Handgrip Assessment. Gerontology (IF 3.5) Pub Date : 2023-06-05 Liza De Dobbeleer,David Beckwée,Pauline Arnold,Stéphane Baudry,Ingo Beyer,Jeroen Demarteau,Siddhartha Lieten,Ynes Punie,Ivan Bautmans
INTRODUCTION Fatigue resistance (FR) can be assessed as the time during which grip strength (GS) drops to 50% of its maximum during a sustained maximal voluntary contraction. For the first time, we compared force-time characteristics during FR test between two different handgrip systems and investigated age- and clinical-related differences in order to verify if a briefer test protocol (i.e., until
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Toward a Flexible Use of Frailty Measurements in Older People. Gerontology (IF 3.5) Pub Date : 2023-05-26 Michaël C J Van der Elst,Birgitte Schoenmakers,Jos M G A Schols,Nico De Witte,Jan De Lepeleire,
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Cognition and Financial Decision-Making in Older Adult Spouses. Gerontology (IF 3.5) Pub Date : 2023-05-24 Sarah P Coundouris,Sylvain Hohn,Anup Basu,Uwe Dulleck,Julie D Henry,Nicolas Cherbuin
INTRODUCTION Age-related decline in executive functioning has been found to negatively impact one's capacity to make prudent financial decisions. The broader literature also speaks to the importance of considering interrelatedness in older spouses' functioning, as these individuals typically represent one's longest and closest relationship that involves an extended history of shared experiences. Accordingly
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Sensor-Based Assessment of Variability in Daily Physical Activity and Frailty. Gerontology (IF 3.5) Pub Date : 2023-05-10 Danya Pradeep Kumar,Bijan Najafi,Kaveh Laksari,Nima Toosizadeh
INTRODUCTION Frailty is a common geriatric syndrome associated with decline in physiological reserve. While several digital biomarkers of daily physical activity (DPA) have been used in frailty assessment, the association between DPA variability and frailty is still not clear. The goal of this study was to determine the association between frailty and DPA variability. METHODS This is an observational
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Blood Biomarkers for Healthy Aging Gerontology (IF 3.5) Pub Date : 2023-04-25 Ceereena Ubaida-Mohien, Toshiko Tanaka, Qu Tian, Zenobia Moore, Ruin Moaddel, Nathan Basisty, Eleanor M Simonsick, Luigi Ferrucci
Measuring the abundance of biological molecules and their chemical modifications in blood and tissues has been the cornerstone of research and medical diagnoses for decades. Although the number and variety of molecules that can be measured have expanded exponentially, the blood biomarkers routinely assessed in medical practice remain limited to a few dozen, which have not substantially changed over
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Brain Structural Correlates of Obstacle Negotiation in Mild Cognitive Impairment: Results from The Gait and Brain Study Gerontology (IF 3.5) Pub Date : 2023-04-25 Frederico Pieruccini-Faria, Seyyed Mohammad Hassan, Nickolas W Bray, Yanina Sarquis-Adamson, Robert Bartha, Manuel Montero-Odasso
Introduction- Mild Cognitive Impairment (MCI) affects obstacle negotiation capabilities, potentially increasing the risk of falls in older adults. However, it is unclear whether smaller brain volumes typically observed in older individuals with MCI are related to the observed hazardous obstacle negotiation in this population. Methods- A total of 93 participants (71.9±5.36years of age; MCI=53 / Control=40)
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Long-term effects of a COMPASS program on the caregiving journey: 1-year follow-up in a randomized controlled trial Gerontology (IF 3.5) Pub Date : 2023-04-25 Eun-Jeong Han, Myonghwa Park , Thi-Thanh-Tinh Giap
Introduction: The number of older adults requiring long-term care (LTC) is increasing rapidly worldwide. The primary family caregivers of LTC recipients experience ongoing burdens and various challenges in their caregiving that adversely affect their own health and also the quality of caring that they provide to their loved ones. As a country becoming a super-aged society, South Korea has been making
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Leisure Activities, Genetic Risk, and Frailty: Evidence from the Chinese Adults Aged 80 Years or Older Gerontology (IF 3.5) Pub Date : 2023-04-19 Jinhui Zhou, Xinwei Li, Xiang Gao, Yuan Wei, Lihong Ye, Sixin Liu, Jiaming Ye, Yidan Qiu, Xulin Zheng, Chen Chen, Jun Wang, Virginia Byers Kraus, Yuebin Lv, Chen Mao, Xiaoming Shi
Introduction: About half of adults aged ≥ 80 years suffer from frailty. Exercise is considered effective in preventing frailty but may be inapplicable to adults aged ≥ 80 years due to physical limitations. As an alternative, we aimed to explore the association of leisure activities with frailty and identify potential interaction with established polygenic risk score (PRS) among adults aged ≥ 80 years
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Aging with HIV: Working to Ensure Equity and Inclusion Gerontology (IF 3.5) Pub Date : 2023-04-18 Mark Brennan-Ing, Eleni Mattas
Due to effective anti-retroviral therapy (ART), the people with HIV are aging, and this is observed globally wherever ART is readily available. While this represents the success of HIV treatment, those aging with HIV face several health challenges that emphasize the importance of access to health care and health equity. These challenges include changes to the immune system, chronic inflammation, and
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The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia Gerontology (IF 3.5) Pub Date : 2023-04-18 Anders Rydström, Ruth Stephen, Ingemar Kåreholt, Alexander Darin Mattsson, Tiia Ngandu, Jenni Lehtisalo, Lars Bäckman, Nina Kemppainen, Juha Rinne, Shireen Sindi, Hilkka Soininen, Ritva Vanninen, Alina Solomon, Francesca Mangialasche
Introduction: Mechanisms underlying the positive association between occupational mental demands and late-life cognition are poorly understood. The objective of this study was to assess whether the association between occupational complexity and cognition is related to and moderated by brain integrity in individuals at-risk for dementia. Brain integrity was appraised throughout structural measures
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Caregiver Involvement and Concerns with Care of Residents of Assisted Living Before and During the COVID-19 Pandemic Gerontology (IF 3.5) Pub Date : 2023-04-17 Matthias Hoben, Wenshan Li, Hana Dampf, David B. Hogan, Kyle Corbett, Stephanie A. Chamberlain, Kim McGrail, Lauren E. Griffith, Andrea Gruneir, Natasha E. Lane, Jennifer Baumbusch, Colleen Maxwell
Introduction Family/friend caregivers play an essential role in promoting the physical and mental health of older adults in need of care – especially during the COVID-19 pandemic and especially in assisted living (AL) homes, were resident care needs are similarly complex as in long-term care homes but fewer staffing resources and services are available. However, little research is available on caregiver