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Cerebrovascular Hemodynamics in Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Transcranial Doppler Studies. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-11-26 David Fresnais,Håkon Ihle-Hansen,Erik Lundström,Åsa G Andersson,Brynjar Fure
INTRODUCTION Transcranial Doppler sonography (TCD) is a non-invasive tool for measuring cerebrovascular hemodynamics. Studies have reported alterations in cerebrovascular hemodynamics in normal aging, mild cognitive impairment (MCI) and dementia, as well as in different etiologies of dementia. This systematic review and meta-analysis was designed to investigate the relationship between cerebral blood
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Association of Cardiovascular Health with Cognitive Function in U.S. Older Adults: a population-based cross-sectional study. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-11-17 Ruihuan Shen,Xuantong Guo,Tong Zou,Lihong Ma
BACKGROUND Promoting cardiovascular health (CVH) by Life's Simple 7 is associated with better cognitive function. In 2022, the American Heart Association (AHA) prompted Life's Essential 8 (LE8) to strengthen CVH assessment. This study investigated the association between the new CVH metrics assessed by LE8 and cognitive function, thus providing evidence for implementing LE8 in the primordial prevention
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The Memory Alteration Test is correlated with clinical, cerebrospinal fluid, and brain imaging markers of Alzheimer disease in Lima, Peru. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-10-12 Nilton Custodio,Marco Malaga,Rosa Montesinos,Diego Chambergo-Michilot,Fiorella Baca,Juan Carlos Carbajal,Jose Carlos Huilca,Eder Herrera-Perez,David Lira,Monica M Diaz,Serggio Lanata
INTRODUCTION As disease modifying therapies become available, early detection of Alzheimer's disease (AD) becomes increasingly important. However, biomarkers in LMICs are rare and costly. Thus, we evaluated an AD-focused BCT, the Memory Alteration Test (M@T), to detect biomarker-proven AD and quantify its correlation with neurodegeneration and CSF AD biomarkers in a cohort of participants from Lima
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Association between low vitamin D status, serotonin and clinico-bio-behavioral parameters in Alzheimer's disease. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-10-06 Anna-Lena Richter,Marlies Diepeveen-de Bruin,Michiel G J Balvers,Lisette C P G M De Groot,Peter Paul De Deyn,Sebastiaan Engelborghs,Renger F Witkamp,Yannick Vermeiren
BACKGROUND Studies suggest a role of vitamin D in the progression and symptomatology of Alzheimer's disease (AD), with few in vitro studies pointing to effects on serotonergic and amyloidogenic turnover. However, limited data exist in AD patients and on the potential association with cognition, and behavioral and psychological signs and symptoms of dementia (BPSD). In this retrospective cross-sectional
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Effect of Computerized Training Programs for Attention and Perception for Patients with Hearing Aids. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-10-04 Mustafa Basaran,Hande Arslan,Funda Kutlu
Introduction Sensorineural hearing loss is a common problem, especially among geriatric patients, and it requires hearing aids. Unfortunately, most geriatric patients are hesitant to use hearing aids. Purpose of this study is to investigate whether computerized training therapies increase the attention and perception of patients who have been given hearing aids using psychophysiological tests and wave
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The External Validation of the Nursing Homes Short Depression Inventory in Older Adults with Major Neurocognitive Disorders in Long-Term Care Centers. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-08-14 Élodie Toulouse,Daphnée Carrier,Maire-Pier Villemure,Jessika Roy Desruisseaux,Christian M Rochefort
INTRODUCTION Depression is often difficult to detect in long-term care (LTC) patients with major neurocognitive disorders (MNCD), and an observer-rated screening scale could facilitate assessments. This study aimed to establish the external validity and reliability of the Nursing Homes Short Depression Inventory (NH-SDI) in LTC patients with MNCD and to compare its estimates to the Cornell Scale for
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Fluctuations in Cognitive Test Scores and Loss to Follow-up in Community-Dwelling Older Adults: The IRIDE Cohort Study. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-08-10 Takumi Abe,Mari Yamashita,Yoshinori Fujiwara,Hiroyuki Sasai,Shuichi P Obuchi,Tatsuro Ishizaki,Shuichi Awata,Kenji Toba,
INTRODUCTION We examined the relationship between previous fluctuations in Mini-Mental State Examination (MMSE) scores, future changes in MMSE scores, and attrition from follow-up surveys, which helps a more comprehensive interpretation of repeatedly collected MMSE scores. METHODS This 4-year longitudinal study included 2,073 community-dwelling older adults aged ≥65 years in Japan. The MMSE was administered
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Association of Lifelong Cognitive Reserve with Dementia and Mild Cognitive Impairment among Older Adults with Limited Formal Education: A Population-Based Cohort Study. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-07-29 Yuanjing Li,Yifei Ren,Lin Cong,Tingting Hou,Lin Song,Mingqi Wang,Xiang Wang,Xiaojuan Han,Shi Tang,Qinghua Zhang,Serhiy Dekhtyar,Yongxiang Wang,Yifeng Du,Chengxuan Qiu
INTRODUCTION Early-life educational attainment contributes to cognitive reserve (CR). We investigated the associations of lifelong CR with dementia and mild cognitive impairment (MCI) among older people with limited formal education. METHODS This population-based cohort study included 2,127 dementia-free participants (≥60 years; 59.4% women; 81.5% with no or elementary school) who were examined at
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Predicting Alzheimer's Disease with Interpretable Machine Learning. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-07-21 Maoni Jia,Yafei Wu,Chaoyi Xiang,Ya Fang
INTRODUCTION This study aimed to develop novel machine learning models for predicting Alzheimer's disease (AD) and identify key factors for targeted prevention. METHODS We included 1,219, 863, and 482 participants aged 60+ years with only sociodemographic, both sociodemographic and self-reported health, both the former two and blood biomarkers information from Alzheimer's Disease Neuroimaging Initiative
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Explainable Alzheimer's Disease Detection Using Linguistic Features from Automatic Speech Recognition. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-07-11 Lijuan Tang,Zhenglin Zhang,Feifan Feng,Li-Zhuang Yang,Hai Li
INTRODUCTION Alzheimer's disease (AD) is the most prevalent type of dementia and can cause abnormal cognitive function and progressive loss of essential life skills. Early screening is thus necessary for the prevention and intervention of AD. Speech dysfunction is an early onset symptom of AD patients. Recent studies have demonstrated the promise of automated acoustic assessment using acoustic or linguistic
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Combining Physical and Cognitive Functions to Discriminate Level of Gait Independence in Hospitalized Patients with Alzheimer's Disease. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-06-14 Keita Nakagawa,Shusaku Kanai,Sosuke Kitakaze,Hitoshi Okamura
INTRODUCTION Both physical and cognitive functions are required to be assessed to determine the level of gait independence in patients with Alzheimer's disease (AD); nonetheless, a method to achieve this assessment has not been established. This study aimed to investigate the accuracy of an assessment method that combined muscle strength, balance ability, and cognitive function parameters in discriminating
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The Utility of Visual and Spatial Perception Tests in Alzheimer's Disease: A Systematic Review. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-06-02 Jonathan P Scott,Donnchadh F Murphy,Rupert F Noad
INTRODUCTION Visual and spatial perception (VSP) are cognitive domains frequently assessed in the screening and neuropsychological assessment of dementia. Evidence suggests that VSP impairment is common in the early stages of Alzheimer's disease (AD). Despite this evidence, the ability of VSP tests to discriminate between healthy older adults and people with AD remains mixed. The purpose of this literature
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Evaluation of a Dementia Training Course for Staff of a Center of Dementia Care. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-05-31 Natália Duarte,Sara Alves,Barbara Gomes
INTRODUCTION Literature shows poor dementia training and competencies among health and social professionals. Due to the growing prevalence of people with dementia and all the related care demands, specialized training is increasingly needed but must be effective in terms of impact on knowledge, behaviors, and attitudes. We aimed to analyze the impact of a first-level dementia training course for staff
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Analysis of Concomitant Medications Prescribed with Antipsychotics to Patients with Dementia. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-05-26 Yoshitaka Saito,Satoru Oishi,Takeya Takizawa,Hiroyuki Muraoka,Yuki Yoshimura,Itsuki Hashimoto,Ryutaro Suzuki,Tsuyoshi Ono,Ken Inada
INTRODUCTION Antipsychotics are still commonly prescribed to patients with dementia, despite the many issues that have been identified. This study aimed to quantify antipsychotic prescription in patients with dementia and the types of concomitant medications prescribed with antipsychotics. METHODS A total of 1,512 outpatients with dementia who visited our department between April 1, 2013 and March
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Hearing Loss and Dementia: A Population-Based Cohort Study. Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-05-10 Keshinisuthan Kirubalingam,Paul Nguyen,Daniel Newsted,Sudeep S Gill,Allison De La Lis,Jason A Beyea
INTRODUCTION Hearing loss (HL) is considered a potentially modifiable risk factor for dementia. We aimed to examine the relationship between HL and incident dementia diagnosis in a province-wide population-based cohort study with matched controls. METHODS Administrative healthcare databases were linked to generate a cohort of patients who were aged ≥40 years at their first claimed hearing amplification
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Carnosine-based reversal of diabetes-associated cognitive decline via activation of the Akt/mTOR pathway and modulation of autophagy in a rat model of type 2 diabetes mellitus Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-04-19 Rodgers Odhiambo Ndolo, Lu Yu, Yan Zhao, Jinying Lu, Gao Wang, Xinmin Zhao, Yi Ren, Jing Yang
Introduction: Carnosine show robust neuroprotective activity against neurodegenerative diseases. Here, we report that carnosine ameliorates diabetes-associated cognitive decline in vivo through the modulation of autophagy. Methods: A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague–Dawley rats. The rats were
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Staff Training Interventions to Prevent or Reduce Behavioural and Psychological Symptoms of Dementia in Nursing Home Residents: A Mixed Methods Systematic Review Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-04-19 Daphnée Carrier, Élodie Toulouse, Christian M. Rochefort
Introduction: Nursing home (NH) staff mention knowledge deficits regarding the management of behavioural and psychological symptoms of dementia (BPSDs) in residents with neurocognitive disorders (NCDs). Staff training therefore appears to be necessary, however existing evidence on best training practices and their outcomes remain scattered. This systematic review aimed to: 1) identify the best clinical
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Knowledge and Attitudes towards Dementia among the General Public in Singapore: A Comparative Analysis Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-04-20 Gurpreet Kaur Hansra, Hazel Lim, Chin Yee Cheong, Philip Yap
Introduction: This paper provides a summary of findings on the public’s knowledge and attitudes towards dementia. We aim to investigate if the attitudes of Singaporeans towards dementia have changed over the years by adopting a questionnaire used in a similar study in 2012. Methods: A cross-sectional, descriptive study was conducted through the dissemination of an existing, online questionnaire to
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Comprehensive Bibliometric Analysis of Stem Cell Research in Alzheimer’s Disease from 2004 to 2022 Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-04-17 Rui Wang, Yi Zhu, Lan-Fang Qin, Zhi-Guo Xu, Xi-Ren Gao, Chong-Bin Liu, Guo-Tong Xu, Yi-Zhu Chen
Introduction: Stem cell-based regenerative medicine has provided an excellent opportunity to investigate therapeutic strategies and innovative treatments for Alzheimer’s disease (AD). However, there is an absence of visual overviews to assess the published literature systematically. Methods: In this review, the bibliometric approach was used to estimate the searched data on stem cell research in AD
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Health Profiles Among Community-Dwelling Older Adults with Cognitive Impairment and Their Implications for Caregiving Experience Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-04-13 Pildoo Sung, Jeremy Lim-Soh, Angelique Chan
Introduction. Identifying health conditions of persons with cognitive impairment (PCI) in the community and exploring their implications for caregiving experience are vital for effective allocation of healthcare resources. This study examined distinct PCI health profiles among community-dwelling PCI and their association with caregiver burden and benefits. Methods. Latent profile analysis and multivariable
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Baseline Predictors of Longitudinal Cognitive Outcomes in Persons with Mild Cognitive Impairment Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-04-04 Prashanth Poulose, Ravi Prasad Varma, Meenu Surendran, Sushama S. Ramachandran, P.G. Rajesh, Bejoy Thomas, Chandrasekaran Kesavadas, Ramshekhar N. Menon
Introduction: The study aimed to explore longitudinal cognitive outcomes and to ascertain predictors of conversion to dementia in a hospital-based mild cognitive impairment (MCI) cohort classified according to the neuropsychological phenotype at baseline. Materials and Methods: Subjects aged gt;55 years who had a clinical diagnosis of MCI at initial visit between 2010 and 2018, with at least one formal
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A Psychological Intervention Program for Patients with Cerebral Infarction Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-03-31 Tianjiao Xu, Fengying Tao, Ping Dong, Haixia Wang, Zhongying Shi
Introduction: Cerebral infarction is one of the most common cerebrovascular diseases. The sequelae caused by cerebral infarction, including limb paralysis, crooked mouth corners, language barriers, etc., seriously affect the patient’s physical and mental health and enthusiasm for rehabilitation training. Therefore, psychological intervention has important positive significance for the rehabilitation
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Supervised, Self-Administered Tablet-Based Cognitive Assessment in Neurodegenerative Disorders and Stroke Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-03-30 Kelly L. Sloane, Rachel Fabian, Amy Wright, Sadhvi Saxena, Kevin Kim, Colin M. Stein, Zafer Keser, Shenly Glenn, Argye E. Hillis
Introduction: As the population ages, the prevalence of cognitive impairment is expanding. Given the recent pandemic, there is a need for remote testing modalities to assess cognitive deficits in individuals with neurological disorders. Self-administered, remote, tablet-based cognitive assessments would be clinically valuable if they can detect and classify cognitive deficits as effectively as traditional
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Non-Pharmacological Treatments in Lewy Body Disease: A Systematic Review Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-03-28 Lucia Guidi, Stefania Evangelisti, Andrea Siniscalco, Raffaele Lodi, Caterina Tonon, Micaela Mitolo
Introduction: Lewy body disease (LBD) is the second most common neurodegenerative disorder in patients older than 65 years. LBD is characterized by heterogeneous symptoms like fluctuation in attention, visual hallucinations, Parkinsonism, and REM sleep behaviour disorders. Considering the relevant social impact of the disease, identifying effective non-pharmacological treatments is becoming a priority
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Risk factors of dementia in patients with cerebral vascular diseases based on Taiwan National Health Insurance data Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-03-22 Bin Zhou, Cheng-Li Lin, Shinsuke Kojima, Masanori Fukushima, Chung Y Hsu
Abstract INTRODUCTION: Vascular factors have been shown to be associated with increased risk of dementia. However, clinical trials have so far been unsuccessful, suggesting new approaches are needed. The aim of this study was to use population-based real world data to investigate risk factors and preventive factors for dementia, including the effects of traditional Chinese medicine. METHODS: This is
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Accuracy of Observer-Rated Measurement Scales for Depression Assessment in Patients with Major Neurocognitive Disorders Residing in Long-Term Care Centers: A Systematic Review Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-03-15 Élodie Toulouse, Daphnée Carrier, Marie-Pier Villemure, Jessika Roy-Desruisseaux, Christian M. Rochefort
Introduction: Depression is often under-detected in long-term care (LTC) patients with major neurocognitive disorders (MNCD) and is associated with important morbidity, mortality, and costs. Observer-rated outcome measures (ObsROMs) could help resolve this problematic; however, evidence on their accuracy is scattered in the literature. This systematic review aimed at summarizing this evidence. Methods:
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Correlation between the regional brain volume and glymphatic system activity in progressive supranuclear palsy Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-03-13 Miho Ota, Noriko Sato, Yuji Takahashi, Yoko Shigemoto, Yukio Kimura, Moto Nakaya, Emiko Chiba, Hiroshi Matsuda
Introduction: Tau protein accumulation in the brain is thought to be one of the causes of progressive supranuclear palsy (PSP). The glymphatic system was discovered a decade ago as a waste drainage system in the brain that promotes the elimination of amyloid-beta and tau protein. We here evaluated the relationships between glymphatic system activity and regional brain volumes in PSP patients. Method:
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Antiepileptic drugs modulate Alzheimer-related tau aggregation in a neuronal activity-independent manner Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-03-06 Yuki Ito, Shuko Takeda, Sayaka Moroi, Tsuneo Nakajima, Akane Oyama, Kunihiro Miki, Nanami Sugihara, Yoichi Takami, Yasushi Takeya, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita
Introduction: A rapidly increasing number of patients with dementia present a serious social problem. Recently, the incidence of epilepsy in patients with Alzheimer's disease (AD) is increasing, drawing attention to the pathological relationship between the two conditions. Clinical studies have suggested the protective action of antiepileptic agents on dementia; however, the underlying mechanism remains
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Acknowledgemt to Reviewers Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-02-23
Dement Geriatr Cogn Disord 2022;51:499–500
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Contents Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-02-23
Dement Geriatr Cogn Disord 2022;51:I–VI
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Note of Thanks: Victoria Chan-Palay Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-02-22 Victoria Chan-Palay
Dement Geriatr Cogn Disord
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Systolic Blood Pressure Is Associated with Increased Brain Amyloid Load in Mild Cognitively Impaired Participants: Alzheimer’s Disease Neuroimaging Initiatives Study Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-02-20 Thomas V. Fungwe, Julius S. Ngwa, Steven P. Johnson, Jilian V. Turner, Mara I. Ramirez Ruiz, Oludolapo O. Ogunlana, Fikru B. Bedada, Sheeba Nadarajah, Oyonumo E. Ntekim, Thomas O. Obisesan
Background: Cardiovascular disease (CVD), including elevated blood pressure (BP), is known to promote Alzheimer’s disease (AD) risk. Although brain amyloid load is a recognized hallmark of pre-symptomatic AD, its relationship to increased BP is less known. The objective of this study was to examine the relationship of BP to brain estimates of amyloid-β (Aβ) and standard uptake ratio (SUVr). We hypothesized
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Psychometric Performance of the Memory Complain Scale among Colombian Individuals of 60 Years and Older Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-02-14 Adalberto Campo-Arias, Carlos Alfonso Reyes-Ortiz
Introduction: The Memory Complaint Scale (MCS-15) is a 15-item instrument to explore frequent forgetfulness in daily life in people with possible cognitive impairment. However, knowledge about its psychometric performance is limited. Objective: The objective of this study was to know the dimensionality and internal consistency of the MCS-15 in Colombian older adults. Methods: A probabilistic sample
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Blood Biomarkers of Neuronal/Axonal and Glial Injury in Human Immunodeficiency Virus-Associated Neurocognitive Disorders Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-02-06 Natalia P. Rocha, Antonio L. Teixeira, Gabriela D. Colpo, Michelle A. Babicz, Jennifer L. Thompson, Steven Paul Woods
Introduction: Approximately half of the people living with HIV (PLWH) experience HIV-associated neurocognitive disorders (HANDs). However, the neuropathogenesis of HAND is complex, and identifying reliable biomarkers has been challenging. Methods: This study included 132 participants aged 50 and older from greater San Diego County. The participants were divided into three groups: PLWH with HAND (n
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Stepping into the Role of Editor-In-Chief Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-02-06 John B. Kwok
Dement Geriatr Cogn Disord
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Clinical Outcomes of Older Persons and Persons with Dementia Admitted for Coronavirus Disease 2019: Findings from the Philippine CORONA Study Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-01-26 Veeda Michelle M. Anlacan, Bernadeth Lyn C. Piamonte, Marie Charmaine C. Sy, Emilio Q. Villanueva III, Roland Dominic G. Jamora, Adrian I. Espiritu
Introduction: The Philippine CORONA Study was a multicenter, retrospective, cohort study of 10,881 coronavirus disease 2019 (COVID-19) admissions between February and December 2020. Methods: Subgroup analysis was done on clinical outcomes of mortality, respiratory failure, duration of ventilator dependence, intensive care unit (ICU) admission, length of ICU stay, and length of hospital stay among older
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Benefits of Caregiver Counseling in Patients with Dementia: A Retrospective Observational Study Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-01-23 Po-Chih Chen, Hsun-Hua Lee, Lung Chan, Chaur-Jong Hu
Introduction: Patients with dementia have a 1.42 times higher risk of hospitalization than those without. Preparing and educating caregivers by counseling may attenuate the frequency of hospitalization and the financial burden on the health-care system. We conducted a retrospective observational study to verify whether caregiver counseling would benefit patients with mild cognitive impairment (MCI)
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The Role of Insulin-Like Growth Factor 1 in Delirium: A Systematic Review and Meta-Analysis Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-01-23 Dimitrios Adamis, Piet Eikelenboom
Background: The relationship between delirium and low levels of insulin-like growth factor 1 (IGF-1) is contradictory and uncertain. We hypothesised that low levels of IGF-1 are a predisposing factor for delirium in medical and abdominal surgical cohorts, in contrast to other surgical cohorts. Aims: Systematic review and meta-analysis investigating the association between peripheral levels of IGF-1
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Subjective Memory Complaints and Their Relationship with the Objective Cognitive Performance of Stroke Patients Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-01-19 Jun Hun Sung, SangYun Kim, Joon-Ho Shin
Introduction: Subjective memory complaints (SMCs) are common among patients with stroke, significantly affect long-term disability, and contribute to poor functional outcomes. We explored changes in the subjective memory complaints questionnaire (SMCQ) score of stroke patients, correlations among SMCs, objective cognitive performance (OCP), and functional status. We also explored whether participants
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Dementia and Geriatric Cognitive Disorders and Dementia and Geriatric Cognitive Disorders Extra: A New Cycle Begins! Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2023-01-04 John B. Kwok, Victoria Chan-Palay, Mary N. Haan, Stefanie Auer, Melissa Slavin, Ramit Ravona-Springer, Jeffrey L. Cummings, Martin Rossor, I. Rosén, C.L. Masters, Etienne Hirsch, K. Urakami, Jordi Pérez-Tur, Samuel E. Gandy, A. Brun, Mony de Leon, Edmond Teng, Barry Reisberg, Jean-Francois Dartigues, Jean-Christoph Bier, Barbara Caracciolo, Eneida Mioshi, Tze-Pin Ng, Marta Altieri, David L. Bachmann
Dement Geriatr Cogn Disord
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Structural Cerebral Network Differences in Prodromal Alzheimer’s Disease and Prodromal Dementia with Lewy Bodies Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-12-27 Miho Ota, Kiyotaka Nemoto, Miyuki Nemoto, Yuriko Numata, Ayako Kitabatake, Yasunori Yamada, Kaoru Shinkawa, Masatomo Kobayashi, Tetsuaki Arai
Introduction: Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) have long prodromal phases without dementia. However, the patterns of cerebral network alteration in this early stage of the disease remain to be clarified. Method: Participants were 48 patients with mild cognitive impairment (MCI) due to AD (MCI-AD), 18 patients with MCI with DLB (MCI with Lewy bodies: MCI-LB), and 23 healthy
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Exercise by Shaking Alleviates the Decline in Memory due to Aging: A Study in Mice Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-12-14 Sho Izawa, Kouji Yamada, Runhong Yao, Naoki Aizu, Takumi Kito, Daiki Iwata, Takeshi Chihara, Hirohide Sawada, Kazuhiro Nishii
Introduction: Although exercise can prevent cognitive decline due to aging, few elderly individuals are able to exercise for long. Therefore, an exercise method for older adults that is feasible for a long duration without overexertion is necessary. In this study, we focused on exercise by shaking. This study examined the possibility to prevent the decline in memory through regular and long-term shaking
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Blunt Traumatic Brain Injury and Alzheimer Pathology Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-12-12 Kurt A. Jellinger
Introduction: Traumatic brain injury (TBI) has been associated with a greater risk of late-life dementia, including Alzheimer’s disease (AD), but only a few studies examined the relationship between residuals of blunt TBI and autopsy-proven AD. The objective of the present study was to examine the incidence of fully developed AD pathology after documented blunt TBI, and the frequency of residuals of
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Shorter Version of the Brain Assessment Is Suitable for Longitudinal Public Cognitive Evaluations Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-12-01 Masayuki Satoh, Ken-ichi Tabei, Makiko Abe, Chiaki Kamikawa, Saiko Fujita, Yoshinori Ota
Introduction: We have developed an online cognitive test (Brain Assessment [BA]) which exhibits moderate correlations with established neuropsychological tests. We made a short version of the BA that requires only 10 min and investigated correlations with the original version. Participants and Methods: Three hundred and twenty-three subjects (26–82 years old, mean age 41.9 years) were recruited via
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Shorter Version of the Brain Assessment Is Suitable for Longitudinal Public Cognitive Evaluations Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-12-01
Introduction: We have developed an online cognitive test (Brain Assessment [BA]) which exhibits moderate correlations with established neuropsychological tests. We made a short version of the BA that requires only 10 min and investigated correlations with the original version. Participants and Methods: Three hundred and twenty-three subjects (26–82 years old, mean age 41.9 years) were recruited via
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Ethnic-Specific Sociodemographic Factors as Determinants of Cognitive Performance: Cross-Sectional Analysis of the Malaysian Elders Longitudinal Research Study Article Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-11-29 Nur Fazidah Asmuje, Sumaiyah Mat, Phyo Kyaw Myint, Maw Pin Tan
Introduction: Despite cognitive impairment being a major health issue within the older population, limited information is available on factors associated with cognitive function among Asian ethnic groups. The objective of this study was to identify ethnic-specific sociodemographic risk factors which are associated with cognitive performance. Methods: Cross-sectional analysis of the Malaysian Elders
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Ethnic-Specific Sociodemographic Factors as Determinants of Cognitive Performance: Cross-Sectional Analysis of the Malaysian Elders Longitudinal Research Study Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-11-29
Introduction: Despite cognitive impairment being a major health issue within the older population, limited information is available on factors associated with cognitive function among Asian ethnic groups. The objective of this study was to identify ethnic-specific sociodemographic risk factors which are associated with cognitive performance. Methods: Cross-sectional analysis of the Malaysian Elders
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Word Recognition Program for Thai Older People with High Risk of Dementia: A Quasi-Experimental One-Group Study Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-11-22 Supaporn Chinchai, Pimpakan Hanpa, Piyawat Trevittaya, Phuanjai Rattakorn, Nahathai Wongpakaran, Wannipa Boonrayong, Piyawan Jaroentonyakorn, Thanasak Kalaysak, Natwipa Wanicharoen
Introduction: Dementia is one of the most common disorders among older people. This condition causes cognitive impairment, which can affect memory, thinking, expressive or comprehension language. It affects work and daily life. The purpose of this study was to examine the effects of a word recognition program on naming and quality of life in older people with high risk of dementia. The purpose of this
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Word Recognition Program for Thai Older People with High Risk of Dementia: A Quasi-Experimental One-Group Study Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-11-22
Introduction: Dementia is one of the most common disorders among older people. This condition causes cognitive impairment, which can affect memory, thinking, expressive or comprehension language. It affects work and daily life. The purpose of this study was to examine the effects of a word recognition program on naming and quality of life in older people with high risk of dementia. The purpose of this
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Development of the Story Telling Examination for Early Mild Cognitive Impairment (Pre-Mild Cognitive Impairment) Screening Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-11-18 Vimonrath Taranop, Yossaya Ruangrajitpakorn, Panika Praputpittaya, Krittapak Lippanon, Ratanasit Tharnpipat, Nahathai Wongpakaran, Tinakon Wongpakaran, Patcharaporn Srisaikaew, Pasuk Mahakkanukrauh, Pairada Varnado, Tong Yang, Carmelle Peisah
Introduction: Cognitive function prior to mild cognitive impairment (MCI) has become a burgeoning interest. Tools used to detect this early period before MCI are being pilot-tested. This study aimed to develop a new test to detect pre-MCI and to examine its content validity and feasibility. Methods: The Story Telling Examination for Early MCI Screening (STEEMS), an audio cognitive test, was developed
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Development of the Story Telling Examination for Early Mild Cognitive Impairment (Pre-Mild Cognitive Impairment) Screening Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-11-18
Introduction: Cognitive function prior to mild cognitive impairment (MCI) has become a burgeoning interest. Tools used to detect this early period before MCI are being pilot-tested. This study aimed to develop a new test to detect pre-MCI and to examine its content validity and feasibility. Methods: The Story Telling Examination for Early MCI Screening (STEEMS), an audio cognitive test, was developed
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Association between Extracranial Carotid Artery Plaque and Cognitive Dysfunction: A Systematic Review and Meta-Analysis Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-10-31 Hediyeh Baradaran, Kelly A. Dahlstrom, Sinead Culleton, Amir Hossein Sarrami, Mary M. McFarland, Jose R. Romero
Background: Extracranial carotid atherosclerosis has been variably associated with dementia. Prior studies have focused on the association of carotid intima media thickness or carotid stenosis; however, there is evidence that carotid plaque may contribute to dementia, perhaps via microembolic phenomena. Objectives: We sought to evaluate the role of carotid plaque in contributing to cognitive impairment
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Association between Extracranial Carotid Artery Plaque and Cognitive Dysfunction: A Systematic Review and Meta-Analysis Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-10-31
Background: Extracranial carotid atherosclerosis has been variably associated with dementia. Prior studies have focused on the association of carotid intima media thickness or carotid stenosis; however, there is evidence that carotid plaque may contribute to dementia, perhaps via microembolic phenomena. Objectives: We sought to evaluate the role of carotid plaque in contributing to cognitive impairment
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Anticholinergic Burden, Polypharmacy, and Cognition in Parkinson’s Disease Patients with Mild Cognitive Impairment: A Cross-Sectional Observational Study Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-10-21 Betul Sumbul-Sekerci, Basar Bilgic, Ozge Pasin, Murat Emre, Hasmet A. Hanagasi
Introduction: Anticholinergic burden may be an important risk factor for the cognitive impairment. Especially in polypharmacy, even drugs with low anticholinergic effects may contribute to a significant anticholinergic burden. The drugs with anticholinergic effects are used in treatment of motor and nonmotor symptoms of Parkinson’s disease (PD). Therefore, it is important to screen for polypharmacy
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The Effect of Thymoquinone on Oxidative Stress Parameters and Apolipoprotein E in Alzheimer Model in Rats Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-10-21 Gökhan Doğukan Akarsu, Aysun Çetin
Introduction: In this study, it was aimed to investigate the effect of thymoquinone (TQ) on oxidative stress and apolipoprotein E (ApoE) in an experimental Alzheimer’s model created with AlCl3 and D-galactose in rats. Methods: Thirty-six Wistar Albino male rats saline group (Group 1), aluminum chloride (AlCl3) + D-galactose (D-Gal) group (Group 2), AlCl3 + D-Gal + TQ group (Group 3) were divided into
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Anticholinergic Burden, Polypharmacy, and Cognition in Parkinson’s Disease Patients with Mild Cognitive Impairment: A Cross-Sectional Observational Study Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-10-21
Introduction: Anticholinergic burden may be an important risk factor for the cognitive impairment. Especially in polypharmacy, even drugs with low anticholinergic effects may contribute to a significant anticholinergic burden. The drugs with anticholinergic effects are used in treatment of motor and nonmotor symptoms of Parkinson’s disease (PD). Therefore, it is important to screen for polypharmacy
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The Effect of Thymoquinone on Oxidative Stress Parameters and Apolipoprotein E in Alzheimer Model in Rats Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-10-21
Introduction: In this study, it was aimed to investigate the effect of thymoquinone (TQ) on oxidative stress and apolipoprotein E (ApoE) in an experimental Alzheimer’s model created with AlCl3 and D-galactose in rats. Methods: Thirty-six Wistar Albino male rats saline group (Group 1), aluminum chloride (AlCl3) + D-galactose (D-Gal) group (Group 2), AlCl3 + D-Gal + TQ group (Group 3) were divided into
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Utilization of Dental Care and the Incidence of Dementia: A Longitudinal Study of an Older Japanese Cohort Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-10-12 Mizuki Saito, Yoshihiro Shimazaki, Toshiya Nonoyama, Kazushi Ohsugi
Introduction: A relationship between periodontal disease and dementia has been reported. It is important to visit a dentist to maintain healthy periodontal tissue. Few studies have been reported on the association between dental visits and the risk of dementia. This study examined the relationship between the use of dental care among older people and the incidence of dementia based on health insurance
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Utilization of Dental Care and the Incidence of Dementia: A Longitudinal Study of an Older Japanese Cohort Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-10-12
Introduction: A relationship between periodontal disease and dementia has been reported. It is important to visit a dentist to maintain healthy periodontal tissue. Few studies have been reported on the association between dental visits and the risk of dementia. This study examined the relationship between the use of dental care among older people and the incidence of dementia based on health insurance
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Diminished Visual Attention to Emotional Faces Is Associated with Poor Emotional Valence Perception in Frontotemporal Dementia Dement. Geriatr. Cogn. Disord. (IF 2.4) Pub Date : 2022-10-10 Suzanne M. Shdo, Casey L. Brown, Joyce Yuan, Robert W. Levenson
Aim: The current study examined whether visual attention to emotional facial expressions is lower in individuals with frontotemporal dementia (FTD) compared to healthy controls, and whether visual attention to emotional facial expressions is associated with the ability to perceive others’ emotional valence accurately. Methods: Participants with FTD (n = 17) and healthy controls (n = 23) passively viewed