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Genetic markers associated with ferroptosis in Alzheimer’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-22 Yuting Sun, Yu Xiao, Qin Tang, Wei Chen, Lu Lin
ObjectiveFerroptosis is implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and vascular dementia, implying that it may have a regulatory effect on the progression of these diseases. However, the specific role of ferroptosis-related genes (FRGs) in Alzheimer’s disease (AD) is not yet fully understood. The aim of the study was to detect ferroptosis
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Detection of elevated levels of PINK1 in plasma from patients with idiopathic Parkinson’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-22 Xianchai Hong, Yi Zheng, Jialong Hou, Tao Jiang, Yao Lu, Wenwen Wang, Shuoting Zhou, Qianqian Ye, Chenglong Xie, Jia Li
BackgroundsNumerous lines of evidence support the intricate interplay between Parkinson’s disease (PD) and the PINK1-dependent mitophagy process. This study aimed to evaluate differences in plasma PINK1 levels among idiopathic PD, PD syndromes (PDs), and healthy controls.MethodsA total of 354 participants were included, consisting of 197 PD patients, 50 PDs patients, and 107 healthy controls were divided
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Neuroanatomical correlates of distracted straight driving performance: a driving simulator MRI study across the lifespan Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-19 Dylan X. Guan, Nathan W. Churchill, Corinne E. Fischer, Simon J. Graham, Tom A. Schweizer
BackgroundDriving is the preferred mode of transportation for adults across the healthy age span. However, motor vehicle crashes are among the leading causes of injury and death, especially for older adults, and under distracted driving conditions. Understanding the neuroanatomical basis of driving may inform interventions that minimize crashes. This exploratory study examined the neuroanatomical correlates
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Incidence and risk factors of age-related macular degeneration in patients with Parkinson’s disease: a population-based study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-19 Bora Yoon, Ho-Seok Sa, Hwa Jung Kim
Background and objectiveThe association between age-related macular degeneration (AMD) and Parkinson’ disease (PD) remains unclear. The aim of the present study was to assess the incidence of AMD in patients with PD, elucidate differences by age and sex, and investigate potential risk factors for AMD.MethodsData were extracted from the Korean National Health Insurance System database, which covers
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SV2A PET imaging in human neurodegenerative diseases Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-18 Mahsa Shanaki Bavarsad, Lea T. Grinberg
This manuscript presents a thorough review of synaptic vesicle glycoprotein 2A (SV2A) as a biomarker for synaptic integrity using Positron Emission Tomography (PET) in neurodegenerative diseases. Synaptic pathology, characterized by synaptic loss, has been linked to various brain diseases. Therefore, there is a need for a minimally invasive approach to measuring synaptic density in living human patients
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Trends in cause-specific mortality among persons with Alzheimer’s disease in South Carolina: 2014 to 2019 Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-17 Candace S. Brown, Xi Ning, Amy Money, Mauriah Alford, Yinghao Pan, Margaret Miller, Matthew Lohman
IntroductionInconsistencies of reports contributes to the underreporting of Alzheimer’s disease (AD) on death certificates. Whether underreporting exists within South Carolina has not been studied.MethodsWe conducted a prospective, population-based study on a cohort of persons (N = 78,534) previously diagnosed with AD and died between 2014–2019. We linked vital records with the South Carolina Alzheimer’s
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Morphological changes in the cerebellum during aging: evidence from convolutional neural networks and shape analysis Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-17 Yu Wang, Ye Teng, Tianci Liu, Yuchun Tang, Wenjia Liang, Wenjun Wang, Zhuoran Li, Qing Xia, Feifei Xu, Shuwei Liu
The morphology and function of the cerebellum are associated with various developmental disorders and healthy aging. Changes in cerebellar morphology during the aging process have been extensively investigated, with most studies focusing on changes in cerebellar regional volume. The volumetric method has been used to quantitatively demonstrate the decrease in the cerebellar volume with age, but it
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Causal relationship between circulating insulin-like growth factor-1 and Parkinson’s disease: a two-sample Mendelian randomization study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-17 Jiahao Xu, Peidong Fan, Jiacheng Yang, Mingjuan Yin, Jun Wu, Chao Chen, Jindong Ni
BackgroundLinear associations between circulating insulin-like growth factor-1 (IGF-1) levels and Parkinson’s disease (PD) have been evidenced in observational studies. Yet, the causal relationship between IGF-1 levels and PD remains obscure. We conducted Mendelian randomization to examine the correlation between genetically predicted IGF-1 levels and PD.MethodsBy reviewing genome-wide association
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Application and progress of advanced eye movement examinations in cognitive impairment Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-17 Qi Leng, Bo Deng, Yi Ju
The worldwide incidence of cognitive impairment is escalating, yet no effective solutions for these afflictions have been discovered. Consequently, the importance of early identification and immediate intervention is heightened. Advanced eye movements—a form of voluntary eye movements that includes anti-saccades, memory-guided saccades, predictive saccades, pro-saccades and gap/overlap saccades, mediated
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The relationship between gender differences in dietary habits, neuroinflammation, and Alzheimer’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-17 Alison Warren
Neurocognitive decline is one of the foremost dire issues in medicine today. The mechanisms by which dementia pathogenesis ensues are complicated and multifactorial, particularly in the case of Alzheimer’s disease (AD). One irrefutable, yet unexplained factor is the gender disparity in AD, in which women are disproportionately affected by AD, both in the rate and severity of the disease. Examining
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Clathrin mediated endocytosis in Alzheimer’s disease: cell type specific involvement in amyloid beta pathology Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-17 Sierra Jaye, Ursula S. Sandau, Julie A. Saugstad
This review provides a comprehensive examination of the role of clathrin-mediated endocytosis (CME) in Alzheimer’s disease (AD) pathogenesis, emphasizing its impact across various cellular contexts beyond neuronal dysfunction. In neurons, dysregulated CME contributes to synaptic dysfunction, amyloid beta (Aβ) processing, and Tau pathology, highlighting its involvement in early AD pathogenesis. Furthermore
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Distance-based novelty detection model for identifying individuals at risk of developing Alzheimer's disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-15 Hongqin Yang, Jiangbing Mao, Qinyong Ye, Magda Bucholc, Shuo Liu, Wenzhao Gao, Jie Pan, Jiawei Xin, Xuemei Ding
IntroductionNovelty detection (ND, also known as one-class classification) is a machine learning technique used to identify patterns that are typical of the majority class and can discriminate deviations as novelties. In the context of Alzheimer's disease (AD), ND could be employed to detect abnormal or atypical behavior that may indicate early signs of cognitive decline or the presence of the disease
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Comparison between morphometry and radiomics: detecting normal brain aging based on grey matter Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-15 Yuting Yan, Xiaodong He, Yuyun Xu, Jiaxuan Peng, Fanfan Zhao, Yuan Shao
ObjectiveVoxel-based morphometry (VBM), surface-based morphometry (SBM), and radiomics are widely used in the field of neuroimage analysis, while it is still unclear that the performance comparison between traditional morphometry and emerging radiomics methods in diagnosing brain aging. In this study, we aimed to develop a VBM-SBM model and a radiomics model for brain aging based on cognitively normal
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Cognitive reserve over the life course and risk of dementia: a systematic review and meta-analysis Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-12 Yulu Liu, Guangyu Lu, Lin Liu, Yuhang He, Weijuan Gong
BackgroundThe number of people with dementia is soaring. Cognitive reserve has been thought to be associated with dementia risk. It is not clear at which period in the life course and which cognitive reserve proxies contribute to the reduced risk of dementia.MethodsBy scanning four databases (PubMed, Embase, Web of Science, and MEDLINE) up to Jun 3, 2023, longitudinal studies of life-course cognitive
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The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-12 Alhamdu Adamu, Shuo Li, Fankai Gao, Guofang Xue
Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a cellular immune response whereby glial cells are activated, inflammatory mediators are liberated and reactive oxygen and nitrogen species are synthesized. Neuroinflammation is a key process that helps protect the brain
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Association of genetically predicted 486 blood metabolites on the risk of Alzheimer’s disease: a Mendelian randomization study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-12 Qiqi Yang, Xinyu Han, Min Ye, Tianxin Jiang, Baoguo Wang, Zhenfeng Zhang, Fei Li
BackgroundStudies have reported that metabolic disturbance exhibits in patients with Alzheimer’s disease (AD). Still, the presence of definitive evidence concerning the genetic effect of metabolites on AD risk remains insufficient. A systematic exploration of the genetic association between blood metabolites and AD would contribute to the identification of new targets for AD screening and prevention
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Associations of vitamin D receptor polymorphisms with risk of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment: a systematic review and meta-analysis Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-12 Yanjun Du, Peizhen Geng, Qunqun Chen, Laixi Han, Lu Liu, Maoquan Yang, Mingzhu Tan, Jun Meng, Xiaojuan Sun, Lidan Feng
Vitamin D is a lipid soluble steroid hormone, which plays a critical role in the calcium homeostasis, neuronal development, cellular differentiation, and growth by binding to vitamin D receptor (VDR). Associations between VDR gene polymorphism and Alzheimer’s disease (AD), Parkinson’s disease (PD), and mild cognitive impairment (MCI) risk has been investigated extensively, but the results remain ambiguous
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Older and younger adults differ in time course of skill acquisition but not in overall improvement in a bimanual visuomotor tracking task Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-11 Ana Zvornik, Keenie Ayla Andersen, Andreas Deigaard Petersen, Mikael Novén, Hartwig Roman Siebner, Jesper Lundbye-Jensen, Anke Ninija Karabanov
Manual motor performance declines with age, but the extent to which age influences the acquisition of new skills remains a topic of debate. Here, we examined whether older healthy adults show less training-dependent performance improvements during a single session of a bimanual pinch task than younger adults. We also explored whether physical and cognitive factors, such as grip strength or motor-cognitive
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The increased effective connectivity from left middle occipital gyrus to right medial septum/diagonal bands in AD patients after donepezil intervention Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-10 Ting Yang, Fuquan Wei, Yufei Guo, Mengxiao Zhu, Hongtao Hou, Zhongwei Guo, Xiaozheng Liu
IntroductionDonepezil enhances the function of cholinergic nerves by increasing the concentration of acetylcholine, thereby improving clinical symptoms in patients with Alzheimer’s disease (AD). However, the neural mechanisms of how donepezil modulates the effective connectivity (EC) network of cholinergic system in AD patients remain unknown. We speculated that the effective network of the cholinergic
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Branched-chain amino acids and the risks of dementia, Alzheimer’s disease, and Parkinson’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-10 Yidong Fu, Yue Wang, Huiming Ren, Xu Guo, Liyuan Han
BackgroundWe aimed to examine the association between blood levels of Branched-chain amino acids (BCAAs) - specifically isoleucine, leucine, and valine - and the susceptibility to three neurodegenerative disorders: dementia, Alzheimer’s disease (AD), and Parkinson’s disease (PD).MethodsBased on data from the UK Biobank, a Cox proportional hazard regression model and a dose–response relationship were
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Biofluid biomarkers for Alzheimer’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-10 Sensen Wang, Sitan Xie, Qinpin Zheng, Zhihui Zhang, Tian Wang, Guirong Zhang
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease, with a complex pathogenesis and an irreversible course. Therefore, the early diagnosis of AD is particularly important for the intervention, prevention, and treatment of the disease. Based on the different pathophysiological mechanisms of AD, the research progress of biofluid biomarkers are classified and reviewed. In the end,
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Multidimensional features of sporadic Creutzfeldt-Jakob disease in the elderly: a case report and systematic review Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-09 Jiangfeng Liao, Wenming Hu, Shiheng Chen, Chunyu Huang, Senwei Dong, Wanjin Chen, Xiaochun Chen, Longfei Chen
BackgroundAs a rare neurodegenerative disease, sporadic Creutzfeldt-Jakob disease (sCJD) is poorly understood in the elderly populace. This study aims to enunciate the multidimensional features of sCJD in this group.MethodsA case of probable sCJD was reported in a 90-year-old Chinese man with initial dizziness. Then, available English literature of the elderly sCJD cases (aged 80 years and over) was
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Association between Life’s Essential 8 and cognitive function: insights from NHANES 2011–2014 Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-08 Kangni Liang, Xiaoling Zhang
IntroductionLife’s Essential 8 (LE8) is prompted by the American Heart Association (AHA) to assess cardiovascular health. The association between LE8 and cognitive function in America is unknown. Our study was to investigate the association of LE8 with cognitive function in general adults.Materials and methodsA total of 2,301 participants were enrolled in the National Health and Nutrition Examination
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Uncorking the limitation—improving dual tasking using transcranial electrical stimulation and task training in the elderly: a systematic review Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-08 Yong Jiang, Perianen Ramasawmy, Andrea Antal
IntroductionWith aging, dual task (DT) ability declines and is more cognitively demanding than single tasks. Rapidly declining DT performance is regarded as a predictor of neurodegenerative disease. Task training and non-invasive transcranial electrical stimulation (tES) are methods applied to optimize the DT ability of the elderly.MethodsA systematic search was carried out in the PUBMED, TDCS (transcranial
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Association analysis of dopaminergic degeneration and the neutrophil-to-lymphocyte ratio in Parkinson’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-08 Fengjiao Zhang, Bin Chen, Wenhua Ren, Yayun Yan, Xiaoqi Zheng, Shuxian Jin, Ying Chang
IntroductionPeripheral inflammatory responses are suggested to play a major role in the pathophysiology of Parkinson’s disease (PD). The neutrophil-to-lymphocyte ratio (NLR), a new recognized biomarker, can reflect peripheral inflammation in PD. However, the association between the NLR and dopaminergic degeneration in PD remains unclear.MethodsIn this retrospective study, 101 enrolled PD patients were
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The role of the nucleus basalis of Meynert in neuromodulation therapy: a systematic review from the perspective of neural network oscillations Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-08 Liwu Jiao, Huicong Kang, Yumei Geng, Xuyang Liu, Mengying Wang, Kai Shu
As a crucial component of the cerebral cholinergic system and the Papez circuit in the basal forebrain, dysfunction of the nucleus basalis of Meynert (NBM) is associated with various neurodegenerative disorders. However, no drugs, including existing cholinesterase inhibitors, have been shown to reverse this dysfunction. Due to advancements in neuromodulation technology, researchers are exploring the
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Age-related changes in static balance in older women aged in their early sixties to their late eighties: different aging patterns in the anterior–posterior and mediolateral directions Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-08 Shun Sasagawa, Ai Arakawa, Aimi Furuyama, Yasuo Matsumoto
ObjectiveThe aim of this study was to cross-sectionally investigate how static balance changes throughout the aging process in older women aged from their early sixties to their late eighties.MethodsForty-six older women (aged 62–89 years) were requested to stand barefoot and quietly on a force platform for 30 s with their eyes either open or closed. During the trials, the position of the center of
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The effects of Tai Chi on standing balance control in older adults may be attributed to the improvement of sensory reweighting and complexity rather than reduced sway velocity or amplitude Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-08 Jianhua Cui, Zengming Hao, Haibo Tian, Yi Yang, Jian Wang, Xiaomei Lin
IntroductionTai Chi has proved to be an effective therapy for balance performance and cognition. However, non-consistency exists in the results of the effect of Tai Chi training on standing balance control in older adults. This study aimed to use traditional and non-traditional methods to investigate the effect of Tai Chi on standing balance in older adults.MethodsThirty-six Tai Chi practitioners (TC
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Machine learning based on the EEG and structural MRI can predict different stages of vascular cognitive impairment Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-05
BackgroundVascular cognitive impairment (VCI) is a major cause of cognitive impairment in the elderly and a co-factor in the development and progression of most neurodegenerative diseases. With the continuing development of neuroimaging, multiple markers can be combined to provide richer biological information, but little is known about their diagnostic value in VCI.MethodsA total of 83 subjects participated
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Increase in activin A may counteract decline in synaptic plasticity with age Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-05
Activin A, a member of the transforming growth factor β (TGF-β) family, is widely recognized for its neurotrophic and neuroprotective function in the developing and injured brain, respectively. Moreover, in the healthy adult brain, activin A has been shown to tune signal processing at excitatory synapses in a fashion that improves cognitive performance. Because its level in human cerebrospinal fluid
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Machine learning based on the EEG and structural MRI can predict different stages of vascular cognitive impairment Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-05 Zihao Li, Meini Wu, Changhao Yin, Zhenqi Wang, Jianhang Wang, Lingyu Chen, Weina Zhao
BackgroundVascular cognitive impairment (VCI) is a major cause of cognitive impairment in the elderly and a co-factor in the development and progression of most neurodegenerative diseases. With the continuing development of neuroimaging, multiple markers can be combined to provide richer biological information, but little is known about their diagnostic value in VCI.MethodsA total of 83 subjects participated
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Increase in activin A may counteract decline in synaptic plasticity with age Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-05 Fang Zheng, Marc Dahlmanns, Philipp Kessler, Christian Alzheimer
Activin A, a member of the transforming growth factor β (TGF-β) family, is widely recognized for its neurotrophic and neuroprotective function in the developing and injured brain, respectively. Moreover, in the healthy adult brain, activin A has been shown to tune signal processing at excitatory synapses in a fashion that improves cognitive performance. Because its level in human cerebrospinal fluid
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Lipocalin-type prostaglandin D synthase: a glymphopathy marker in idiopathic hydrocephalus Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-04
Idiopathic normal pressure hydrocephalus in elderly people is considered a form of glymphopathy caused by malfunction of the waste clearance pathway, called the glymphatic system. Tau is a representative waste material similar to amyloid-β. During neurodegeneration, lipocalin-type prostaglandin D synthase (L-PGDS), a major cerebrospinal fluid (CSF) protein, is reported to act as a chaperone that prevents
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Immediate fall prevention: the missing key to a comprehensive solution for falling hazard in older adults Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-04
The world is witnessing an unprecedented demographic shift due to increased life expectancy and declining birth rates. By 2050, 20% of the global population will be over 60, presenting significant challenges like a shortage of caregivers, maintaining health and independence, and funding extended retirement. The technology that caters to the needs of older adults and their caregivers is the most promising
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Immediate fall prevention: the missing key to a comprehensive solution for falling hazard in older adults Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-04 Khashayar Misaghian, Jesus Eduardo Lugo, Jocelyn Faubert
The world is witnessing an unprecedented demographic shift due to increased life expectancy and declining birth rates. By 2050, 20% of the global population will be over 60, presenting significant challenges like a shortage of caregivers, maintaining health and independence, and funding extended retirement. The technology that caters to the needs of older adults and their caregivers is the most promising
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Lipocalin-type prostaglandin D synthase: a glymphopathy marker in idiopathic hydrocephalus Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-04 Namiko Nishida, Nanae Nagata, Keigo Shimoji, Naoto Jingami, Kengo Uemura, Akihiko Ozaki, Makio Takahashi, Yoshihiro Urade, Sadayuki Matsumoto, Koichi Iwasaki, Ryosuke Okumura, Masatsune Ishikawa, Hiroki Toda
Idiopathic normal pressure hydrocephalus in elderly people is considered a form of glymphopathy caused by malfunction of the waste clearance pathway, called the glymphatic system. Tau is a representative waste material similar to amyloid-β. During neurodegeneration, lipocalin-type prostaglandin D synthase (L-PGDS), a major cerebrospinal fluid (CSF) protein, is reported to act as a chaperone that prevents
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Association of multiple metabolic and cardiovascular markers with the risk of cognitive decline and mortality in adults with Alzheimer’s disease and AD-related dementia or cognitive decline: a prospective cohort study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-02
Background and objectivesThere is a scarcity of data stemming from large-scale epidemiological longitudinal studies focusing on potentially preventable and controllable risk factors for Alzheimer’s disease (AD) and AD-related dementia (ADRD). This study aimed to examine the effect of multiple metabolic factors and cardiovascular disorders on the risk of cognitive decline and AD/ADRD.MethodsWe analyzed
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Oxidative stress in the brain–lung crosstalk: cellular and molecular perspectives Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-03
Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to counteract their harmful effects, playing a key role in the pathogenesis of brain and lung-related diseases. This review comprehensively examines the intricate mechanisms by which oxidative stress influences cellular and molecular pathways, contributing to neurodegenerative,
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Targeting shared pathways in tauopathies and age-related macular degeneration: implications for novel therapies Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-03
The intricate parallels in structure and function between the human retina and the central nervous system designate the retina as a prospective avenue for understanding brain-related processes. This review extensively explores the shared physiopathological mechanisms connecting age-related macular degeneration (AMD) and proteinopathies, with a specific focus on tauopathies. The pivotal involvement
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Physical activity may a probably protective factor for postoperative delirium: the PNDABLE study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-03
ObjectiveThis study aims to explore the relationship between physical activity (PA) and postoperative delirium (POD).MethodsWe selected 400 patients from the Perioperative Neurocognitive Disorder and Biomarkers Lifestyle (PNDABLE) database, and the patients in the PNDABLE database were sampled and tested Alzheimer’s biomarkers. The diagnosis of POD was made using the Confusion Assessment Scale (CAM)
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Oxidative stress in the brain–lung crosstalk: cellular and molecular perspectives Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-03 Jianda Kong, Rao Fan, Yuanqi Zhang, Zixuan Jia, Jing Zhang, Huixin Pan, Qinglu Wang
Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to counteract their harmful effects, playing a key role in the pathogenesis of brain and lung-related diseases. This review comprehensively examines the intricate mechanisms by which oxidative stress influences cellular and molecular pathways, contributing to neurodegenerative,
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Targeting shared pathways in tauopathies and age-related macular degeneration: implications for novel therapies Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-03 Michele Rinaldi, Antonio Pezone, Gaia Italia Quadrini, Gianmarco Abbadessa, Maria Paola Laezza, Maria Laura Passaro, Antonio Porcellini, Ciro Costagliola
The intricate parallels in structure and function between the human retina and the central nervous system designate the retina as a prospective avenue for understanding brain-related processes. This review extensively explores the shared physiopathological mechanisms connecting age-related macular degeneration (AMD) and proteinopathies, with a specific focus on tauopathies. The pivotal involvement
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Physical activity may a probably protective factor for postoperative delirium: the PNDABLE study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-03 Jian Kong, Xu Lin, Bin Wang, Shanling Xu, Yuanlong Wang, Shuhui Hua, Hongyan Gong, Rui Dong, Yanan Lin, Chuan Li, Yanlin Bi
ObjectiveThis study aims to explore the relationship between physical activity (PA) and postoperative delirium (POD).MethodsWe selected 400 patients from the Perioperative Neurocognitive Disorder and Biomarkers Lifestyle (PNDABLE) database, and the patients in the PNDABLE database were sampled and tested Alzheimer’s biomarkers. The diagnosis of POD was made using the Confusion Assessment Scale (CAM)
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Selection of lansoprazole from an FDA-approved drug library to inhibit the Alzheimer’s disease seed-dependent formation of tau aggregates Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-03 Ahmed Imtiaz, Shotaro Shimonaka, Mohammad Nasir Uddin, Montasir Elahi, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori, Yumiko Motoi
The efficacy of current treatments is still insufficient for Alzheimer’s disease (AD), the most common cause of Dementia. Out of the two pathological hallmarks of AD amyloid-β plaques and neurofibrillary tangles, comprising of tau protein, tau pathology strongly correlates with the symptoms of AD. Previously, screening for inhibitors of tau aggregation that target recombinant tau aggregates have been
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Association of multiple metabolic and cardiovascular markers with the risk of cognitive decline and mortality in adults with Alzheimer’s disease and AD-related dementia or cognitive decline: a prospective cohort study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-04-02 Longjian Liu, Edward J. Gracely, Xiaopeng Zhao, Gediminas P. Gliebus, Nathalie S. May, Stella L. Volpe, Jingyi Shi, Rose Ann DiMaria-Ghalili, Howard J. Eisen
Background and objectivesThere is a scarcity of data stemming from large-scale epidemiological longitudinal studies focusing on potentially preventable and controllable risk factors for Alzheimer’s disease (AD) and AD-related dementia (ADRD). This study aimed to examine the effect of multiple metabolic factors and cardiovascular disorders on the risk of cognitive decline and AD/ADRD.MethodsWe analyzed
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Assessing the cognitive decline of people in the spectrum of AD by monitoring their activities of daily living in an IoT-enabled smart home environment: a cross-sectional pilot study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-28 Margarita Grammatikopoulou, Ioulietta Lazarou, Vasilis Alepopoulos, Lampros Mpaltadoros, Vangelis P. Oikonomou, Thanos G. Stavropoulos, Spiros Nikolopoulos, Ioannis Kompatsiaris, Magda Tsolaki
IntroductionAssessing functional decline related to activities of daily living (ADLs) is deemed significant for the early diagnosis of dementia. As current assessment methods for ADLs often lack the ability to capture subtle changes, technology-based approaches are perceived as advantageous. Specifically, digital biomarkers are emerging, offering a promising avenue for research, as they allow unobtrusive
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Frequency-dependent alterations in functional connectivity in patients with Alzheimer’s Disease spectrum disorders Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-28 Hanjun Hu, Luoyu Wang, Sammad Abdul, Xue Tang, Qi Feng, Yuzhu Mu, Xiuhong Ge, Zhengluan Liao, Zhongxiang Ding
BackgroundIn the spectrum of Alzheimer’s Disease (AD) and related disorders, the resting-state functional magnetic resonance imaging (rs-fMRI) signals within the cerebral cortex may exhibit distinct characteristics across various frequency ranges. Nevertheless, this hypothesis has not yet been substantiated within the broader context of whole-brain functional connectivity. This study aims to explore
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Two-sample Mendelian randomization analysis of 91 circulating inflammatory protein levels and amyotrophic lateral sclerosis Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-27 Chenxu Xiao, Xiaochu Gu, Yu Feng, Jing Shen
IntroductionAmyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly understood pathophysiology. Recent studies have highlighted systemic inflammation, especially the role of circulating inflammatory proteins, in ALS.MethodsThis study investigates the potential causal link between these proteins and ALS. We employed a two-sample Mendelian Randomization(MR) approach, analyzing
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Effects of electroacupuncture on postoperative cognitive dysfunction and its underlying mechanisms: a literature review of rodent studies Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-26 Wenbo Zhao, Wei Zou
With the aging of the population, the health of the elderly has become increasingly important. Postoperative cognitive dysfunction (POCD) is a common neurological complication in elderly patients following general anesthesia or surgery. It is characterized by cognitive decline that may persist for weeks, months, or even longer. Electroacupuncture (EA), a novel therapy that combines physical nerve stimulation
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The assessment of executive function abilities in healthy and neurodegenerative aging—A selective literature review Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-26 Mojitola I. Idowu, Andre J. Szameitat, Andrew Parton
Numerous studies have examined executive function (EF) abilities in cognitively healthy older adults and those living with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Currently, there are no standard accepted protocols for testing specific EFs; thus, researchers have used their preferred tool, which leads to variability in assessments of decline in a particular ability across studies
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Irreversible atrophy in memory brain regions over 7 years is predicted by glycemic control in type 2 diabetes without mild cognitive impairment Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-25 Nádia Canário, Joana Crisóstomo, João Valente Duarte, Carolina Moreno, Hugo Quental, Leonor Gomes, Francisco Oliveira, Miguel Castelo-Branco
Memory-related impairments in type 2 diabetes may be mediated by insulin resistance and hyperglycemia. Previous cross-sectional studies have controversially suggested a relationship between metabolic control and a decrease in hippocampal volumes, but only longitudinal studies can test this hypothesis directly. We performed a longitudinal morphometric study to provide a direct test of a possible role
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Causal role of immune cells on risk of Parkinson’s disease: a Mendelian randomization study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-22 Jian Gu, Yue Qiao, Shuyan Cong
BackgroundPrevious observational studies have suggested a correlation between immune cells and Parkinson’s disease (PD), yet specific investigations into the causal relationship between the two remain limited. This study aims to explore this potential causal relationship.MethodsWe utilized genome-wide association study (GWAS) data on immune cells and Parkinson’s Disease, conducting a two-sample Mendelian
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Bibliometric analysis of PTEN in neurodevelopment and neurodegeneration Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-22 Yun Zhang, Ya-ting Tan, Mei-juan Wang, Lan Li, Ju-fang Huang, Shu-chao Wang
Phosphatase and tensin homologue deleted on chromosome ten (PTEN) was initially recognized as a significant regulator of cancer suppression and could impede cancer cell survival, proliferation, and energy metabolism. PTEN is highly expressed in neurons and performs crucial functions in neurogenesis, synaptogenesis, and neuronal survival. Disruption of PTEN activity may also result in abnormal neuronal
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Associative role of HLA-DRB1 as a protective factor for susceptibility and progression of Parkinson’s disease: a Chinese cross-sectional and longitudinal study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-22 Raoli He, Yuqi Zeng, Chaodong Wang, Lina Chen, Guoen Cai, Ying Chen, Yingqing Wang, Qinyong Ye, Xiaochun Chen
BackgroundPrevious genome-wide association studies investigating the relationship between the HLA-DRB1 and the risk of Parkinson’s disease (PD) have shown limited racial diversity and have not explored clinical heterogeneity extensively.MethodsThe study consisted of three parts: a case–control study, a cross-sectional study, and a longitudinal cohort study. The case–control study included 477 PD patients
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Emerging insights into cuproptosis and copper metabolism: implications for age-related diseases and potential therapeutic strategies Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-21 Haohui Fan, Kun Wang, Xiaofang Zhao, Bei Song, Tianci Yao, Ting Liu, Guangyu Gao, Weilin Lu, Chengyun Liu
The expanding geriatric population, whose predisposition toward disabling morbidities and age-related diseases (ARD) is well-documented, has become a paramount social issue, exerting an onerous burden on both the healthcare industry and wider society. ARD manifest as the progressive deterioration of bodily tissues and organs, eventually resulting in the failure of these vital components. At present
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Clinical evidence of hyperbaric oxygen therapy for Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-21 Guangyao Lin, Li Zhao, Jingyu Lin, Xuanling Li, Lianwei Xu
ObjectiveTo evaluate the potential benefits of hyperbaric oxygen intervention on people with Alzheimer’s disease (AD) based on the existing randomized controlled trials (RCTs).MethodsA systematic search was conducted in nine databases until November 17, 2023, for RCTs assessing the effect of hyperbaric oxygen intervention for AD. The primary outcomes included Mini-Mental State Examination (MMSE), Alzheimer’s
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Repetitive transcranial magnetic stimulation for Alzheimer’s disease: an overview of systematic reviews and meta-analysis Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-20 Hua Xue, Ya-xin Li, Ya-song Xiao, Wen-hui Fan, Hong-xian He
ObjectiveAlzheimer’s disease (AD) is a prevalent neurodegenerative condition that significantly impacts both individuals and society. This study aims to evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) as a treatment for AD by summarizing the evidence from systematic reviews (SRs) and meta-analyses (MAs).MethodsSRs/MAs of rTMS for AD were collected by searching Embase
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Association between cognitive function and body composition in older adults: data from NHANES (1999–2002) Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-20 Lianghua Chen, Liling Zou, Jingwen Chen, Yixiao Wang, Dandan Liu, Lianjun Yin, Junqi Chen, Haihong Li
AimTo investigate the association between cognitive function and body composition in older adults.MethodsWe collected data on 2080 older adults (>60 years of age) from the National Health and Nutrition Examination Survey (NHANES) for the years 1999–2000 and 2001–2002. Candidate variables included: demographic data (sex, age, race, education level, marital status, poverty-to-income ratio), alcohol consumption
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Astrocyte expression of aging-associated markers positively correlates with neurodegeneration in the frontal lobe of the rhesus macaque brain Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-20 Miranda D. Horn, Sophia C. Forest, Ahmad A. Saied, Andrew G. MacLean
IntroductionAs the population over the age of 65 increases, rates of neurodegenerative disorders and dementias will rise – necessitating further research into the cellular and molecular mechanisms that contribute to brain aging. With the critical importance of astrocytes to neuronal health and functioning, we hypothesized that alterations in astrocyte expression of aging-associated markers p16INK4a
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Reduced maximal range of ocular movements and its response to acute levodopa challenge in Parkinson's disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-20 Juan Li, Yuewen Li, Xianzhou Chu, Mengxue Jiang, Tieyu Wu, Xianwen Chen
IntroductionAlthough restriction of vertical ocular range of motion is known to be the hallmark of progressive supranuclear palsy (PSP), the maximal amplitude of ocular movement has not been quantitatively assessed despite of accumulating evidences of oculomotor dysfunction in Parkinson's disease (PD). Here, we evaluated the maximal oculomotor range and its response to levodopa in PD, and compare findings