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Assessment of optimal combinations of therapeutic probiotics for depression, anxiety, and stress Psychol. Med. (IF 6.9) Pub Date : 2024-03-18 Yafang Yang, Ligang Yang, Min Wan, Da Pan, Guiju Sun, Chao Yang
Background Accumulating data show that probiotics may be beneficial for reducing depressive, anxiety, and stress symptoms. However, the best combinations and species of probiotics have not been identified. The objective of our study was to assess the most effective combinations and components of different probiotics through network meta-analysis.Method A systematic search of four databases, PubMed
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Childhood correlates and young adult outcomes of trajectories of emotional problems from childhood to adolescence Psychol. Med. (IF 6.9) Pub Date : 2024-03-18 F. Tseliou, L. Riglin, A. K. Thapar, J. Heron, C. A. Dennison, J. M. Armitage, A. Thapar, F. Rice, S. Collishaw
Background Emotional problems, especially anxiety, have become increasingly common in recent generations. Few population-based studies have examined trajectories of emotional problems from early childhood to late adolescence or investigated differences in psychiatric and functional outcomes.Methods Using the Avon Longitudinal Study of Parents and Children (ALSPAC, n = 8286, 50.4% male), we modeled
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A comprehensive hierarchical comparison of structural connectomes in Major Depressive Disorder cases v. controls in two large population samples Psychol. Med. (IF 6.9) Pub Date : 2024-03-18 Gladi Thng, Xueyi Shen, Aleks Stolicyn, Mark J. Adams, Hon Wah Yeung, Venia Batziou, Eleanor L. S. Conole, Colin R. Buchanan, Stephen M. Lawrie, Mark E. Bastin, Andrew M. McIntosh, Ian J. Deary, Elliot M. Tucker-Drob, Simon R. Cox, Keith M. Smith, Liana Romaniuk, Heather C. Whalley
Background The brain can be represented as a network, with nodes as brain regions and edges as region-to-region connections. Nodes with the most connections (hubs) are central to efficient brain function. Current findings on structural differences in Major Depressive Disorder (MDD) identified using network approaches remain inconsistent, potentially due to small sample sizes. It is still uncertain
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Executive functioning, behavior, and white matter microstructure in the chronic phase after pediatric mild traumatic brain injury: results from the adolescent brain cognitive development study Psychol. Med. (IF 6.9) Pub Date : 2024-03-18 Anja K. Betz, Suheyla Cetin-Karayumak, Elena M. Bonke, Johanna Seitz-Holland, Fan Zhang, Steve Pieper, Lauren J. O'Donnell, Yorghos Tripodis, Yogesh Rathi, Martha E. Shenton, Inga K. Koerte
Background Mild traumatic brain injury (mTBI) is common in children. Long-term cognitive and behavioral outcomes as well as underlying structural brain alterations following pediatric mTBI have yet to be determined. In addition, the effect of age-at-injury on long-term outcomes is largely unknown.Methods Children with a history of mTBI (n = 406; Mage = 10 years, SDage = 0.63 years) who participated
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Precision psychiatry: predicting predictability Psychol. Med. (IF 6.9) Pub Date : 2024-03-18 Edwin van Dellen
Precision psychiatry is an emerging field that aims to provide individualized approaches to mental health care. An important strategy to achieve this precision is to reduce uncertainty about prognosis and treatment response. Multivariate analysis and machine learning are used to create outcome prediction models based on clinical data such as demographics, symptom assessments, genetic information, and
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Reduced dorsal fronto-striatal connectivity at rest in anorexia nervosa Psychol. Med. (IF 6.9) Pub Date : 2024-03-18 Alexandra F. Muratore, Karin Foerde, E. Caitlin Lloyd, Caroline Touzeau, Blair Uniacke, Natalie Aw, David Semanek, Yun Wang, B. Timothy Walsh, Evelyn Attia, Jonathan Posner, Joanna E. Steinglass
Background Anorexia nervosa (AN) is a serious psychiatric illness that remains difficult to treat. Elucidating the neural mechanisms of AN is necessary to identify novel treatment targets and improve outcomes. A growing body of literature points to a role for dorsal fronto-striatal circuitry in the pathophysiology of AN, with increasing evidence of abnormal task-based fMRI activation within this network
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The silent epidemic of loneliness: identifying the antecedents of loneliness using a lagged exposure-wide approach Psychol. Med. (IF 6.9) Pub Date : 2024-03-18 Joanna H. Hong, Julia S. Nakamura, Sakshi S. Sahakari, William J. Chopik, Koichiro Shiba, Tyler J. VanderWeele, Eric S. Kim
Background A large and accumulating body of evidence shows that loneliness is detrimental for various health and well-being outcomes. However, less is known about potentially modifiable factors that lead to decreased loneliness.Methods We used data from the Health and Retirement Study to prospectively evaluate a wide array of candidate predictors of subsequent loneliness. Importantly, we examined if
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A longitudinal investigation of caregiving and adolescent post-traumatic stress symptoms during COVID-19: evidence for high resting RSA as a susceptibility factor Psychol. Med. (IF 6.9) Pub Date : 2024-03-14 Linnea B. Linde-Krieger, Kristen L. Rudd, Alexandra S. Aringer, Tuppett M. Yates
Background Post-traumatic stress symptoms (PTSS) were the most frequently reported mental health concern for youth during COVID-19, yet variations in youth's PTSS responses warrant empirical consideration. Features of the caregiving environment influence youth's responses to environmental stressors, and youth's parasympathetic nervous system regulation may qualify the magnitude and/or direction of
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The protective effect of vitamin D supplementation as adjunctive therapy to antidepressants on brain structural and functional connectivity of patients with major depressive disorder: a randomized controlled trial Psychol. Med. (IF 6.9) Pub Date : 2024-03-14 Wenming Zhao, Dao-min Zhu, Yuhao Shen, Yu Zhang, Tao Chen, Huanhuan Cai, Jiajia Zhu, Yongqiang Yu
Background Growing evidence points to the pivotal role of vitamin D in the pathophysiology and treatment of major depressive disorder (MDD). However, there is a paucity of longitudinal research investigating the effects of vitamin D supplementation on the brain of MDD patients. Methods We conducted a double-blind randomized controlled trial in 46 MDD patients, who were randomly allocated into either
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Associations between body weight change and incidence of major depressive disorder in patients with type 2 diabetes mellitus: a nationwide longitudinal follow-up cohort study of 1.1 million Psychol. Med. (IF 6.9) Pub Date : 2024-03-12 Eun Young Kim, You-Bin Lee, Gyu-Na Lee, Kyungdo Han, Su-Min Jeong
Background Comorbid depression substantially affects the management of glycemia and diabetes-related complications among patients with type 2 diabetes mellitus. In this study, we sought to determine the association between weight change over 4 years and depression risk among patients with type 2 diabetes mellitus. Methods This population-based retrospective cohort study from the National Health Insurance
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Increased cardiac vagal tone in childhood-only, adolescent-only, and persistently antisocial teenagers: the mediating role of low heart rate Psychol. Med. (IF 6.9) Pub Date : 2024-03-12 Adrian Raine, Lia Brodrick, Dustin Pardini, J. Richard Jennings, Rebecca Waller
Background Cardiac vagal tone is an indicator of parasympathetic nervous system functioning, and there is increasing interest in its relation to antisocial behavior. It is unclear however whether antisocial individuals are characterized by increased or decreased vagal tone, and whether increased vagal tone is the source of the low heart rate frequently reported in antisocial populations. Methods Participants
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Retinal microvascular function and incidence and trajectories of clinically relevant depressive symptoms: the Maastricht Study Psychol. Med. (IF 6.9) Pub Date : 2024-03-12 April C. E. van Gennip, Monideepa D. Gupta, Alfons J. H. M. Houben, Tos T. J. M. Berendschot, Carroll A. B. Webers, Marleen M. J. van Greevenbroek, Carla J. H. van der Kallen, Annemarie Koster, Anke Wesselius, Simone J. P. M. Eussen, Casper G. Schalkwijk, Bastiaan E. de Galan, Sebastian Köhler, Miranda T. Schram, Coen D. A. Stehouwer, Thomas T. van Sloten
Background Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is limited. We investigated the association of retinal microvascular function, a proxy for microvascular function in the brain, with incidence and trajectories of clinically relevant depressive symptoms. Methods Longitudinal data are from The Maastricht
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Who benefits from indirect prevention and treatment of depression using an online intervention for insomnia? Results from an individual-participant data meta-analysis Psychol. Med. (IF 6.9) Pub Date : 2024-03-12 Janika Thielecke, Paula Kuper, Dirk Lehr, Lea Schuurmans, Mathias Harrer, David D. Ebert, Pim Cuijpers, Dörte Behrendt, Hanna Brückner, Hanne Horvath, Heleen Riper, Claudia Buntrock
Background Major depressive disorder (MDD) is highly prevalent and burdensome for individuals and society. While there are psychological interventions able to prevent and treat MDD, uptake remains low. To overcome structural and attitudinal barriers, an indirect approach of using online insomnia interventions seems promising because insomnia is less stigmatized, predicts MDD onset, is often comorbid
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Pain sensitivity as a state marker and predictor for adolescent non-suicidal self-injury Psychol. Med. (IF 6.9) Pub Date : 2024-03-11 Han-Tin Kao, Ines Mürner-Lavanchy, Elisabeth von Stosch, Johannes Josi, Thomas Berger, Julian Koenig, Michael Kaess
Background The pain analgesia hypothesis suggests that reduced pain sensitivity (PS) is a specific risk factor for the engagement in non-suicidal self-injury (NSSI). Consistent with this, several studies found reduced PS in adults as well as adolescents with NSSI. Cross-sectional studies in adults with borderline personality disorder (BPD) suggest that PS may (partially) normalize after remission or
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The role of depression and use of alcohol and other drugs after partner suicide in the association between suicide bereavement and suicide: cohort study in the Danish population Psychol. Med. (IF 6.9) Pub Date : 2024-03-11 Alexandra Pitman, Keltie McDonald, Yanakan Logeswaran, Glyn Lewis, Julie Cerel, Gemma Lewis, Annette Erlangsen
Background Although suicide bereavement is associated with suicide and self-harm, evidence regarding mechanisms is lacking. We investigated whether depression and substance use (alcohol and/or other drugs) explain the association between partner suicide bereavement and suicide. Methods Linkage of nationwide, longitudinal data from Denmark for the period 1980–2016 facilitated a comparison of 22 668
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Associations between disturbed sleep and attenuated psychotic experiences in people at clinical high risk for psychosis Psychol. Med. (IF 6.9) Pub Date : 2024-03-07 M. J. C. Formica, M. Fuller-Tyszkiewicz, U. Reininghaus, M. Kempton, P. Delespaul, L. de Haan, B. Nelson, A. Mikocka-Walus, L. Olive, S. Ruhrmann, B. Rutten, A. Riecher-Rössler, G. Sachs, L. Valmaggia, M. van der Gaag, P. McGuire, J. van Os, EU-GEI High-Risk Study, J. A. Hartmann
Background Pre-diagnostic stages of psychotic illnesses, including ‘clinical high risk’ (CHR), are marked by sleep disturbances. These sleep disturbances appear to represent a key aspect in the etiology and maintenance of psychotic disorders. We aimed to examine the relationship between self-reported sleep dysfunction and attenuated psychotic symptoms (APS) on a day-to-day basis.Methods Seventy-six
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Longitudinal changes in brain-derived neurotrophic factor (BDNF) but not cytokines contribute to hippocampal recovery in anorexia nervosa above increases in body mass index Psychol. Med. (IF 6.9) Pub Date : 2024-03-07 Johanna Louise Keeler, Klaas Bahnsen, Marie-Louis Wronski, Fabio Bernardoni, Friederike Tam, Dominic Arold, Joseph A. King, Theresa Kolb, David M. Poitz, Veit Roessner, Janet Treasure, Hubertus Himmerich, Stefan Ehrlich
Background Physical sequelae of anorexia nervosa (AN) include a marked reduction in whole brain volume and subcortical structures such as the hippocampus. Previous research has indicated aberrant levels of inflammatory markers and growth factors in AN, which in other populations have been shown to influence hippocampal integrity. Methods Here we investigated the influence of concentrations of two pro-inflammatory
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Neurocognitive correlates of metabolic dysregulation in individuals with mood disorders: a systematic review and meta-analysis Psychol. Med. (IF 6.9) Pub Date : 2024-03-07 Kateryna Maksyutynska, Nicolette Stogios, Femin Prasad, Jashan Gill, Zaineb Hamza, Riddhita De, Emily Smith, Angelina Horta, Benjamin I. Goldstein, Daphne Korczak, Ariel Graff-Guerrero, Margaret K. Hahn, Sri Mahavir Agarwal
Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction
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The effects of intranasal oxytocin on the efficacy of psychotherapy for major depressive disorder: a pilot randomized controlled trial Psychol. Med. (IF 6.9) Pub Date : 2024-03-06 Mark A. Ellenbogen, Christopher Cardoso, Lisa Serravalle, Kiran Vadaga, Ridha Joober
Background Although both pharmacotherapy and psychological treatments are considered to be efficacious in the treatment of major depressive disorder (MDD), one third of patients do not respond to treatment and many experience residual symptoms post-treatment. In this double-blind placebo-controlled randomized control trial (RCT), we assessed whether intranasal oxytocin (OT) augments the therapeutic
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Temporal changes in brain morphology related to inflammation and schizophrenia: an omnigenic Mendelian randomization study Psychol. Med. (IF 6.9) Pub Date : 2024-03-06 Yunjia Liu, Hongyan Ren, Yamin Zhang, Wei Deng, Xiaohong Ma, Liansheng Zhao, Xiaojing Li, Pak Sham, Qiang Wang, Tao Li
Background Over the past several decades, more research focuses have been made on the inflammation/immune hypothesis of schizophrenia. Building upon synaptic plasticity hypothesis, inflammation may contribute the underlying pathophysiology of schizophrenia. Yet, pinpointing the specific inflammatory agents responsible for schizophrenia remains a complex challenge, mainly due to medication and metabolic
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Decision making capacity for treatment in psychiatric inpatients: a systematic review and meta-analysis Psychol. Med. (IF 6.9) Pub Date : 2024-03-04 Silvia Marcó-García, Kevin Ariyo, Gareth S. Owen, Anthony S. David
Decision-making capacity (DMC) among psychiatric inpatients is a pivotal clinical concern. A review by Okai et al. (2007) suggested that most psychiatric inpatients have DMC for treatment, and its assessment is reliable. Nevertheless, the high heterogeneity and mixed results from other studies mean there is considerable uncertainty around this topic. This study aimed to update Okai's research by conducting
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Emotion dynamics in current and remitted depression: an ecological momentary assessment study Psychol. Med. (IF 6.9) Pub Date : 2024-03-04 Mariah T. Hawes, Daniel N. Klein
Background Individuals in a depressive episode and healthy controls exhibit robust differences on affect dynamics captured with ecological momentary assessment (EMA). However, few studies have explored affect dynamics in individuals in remission from depression, and results have been mixed. Methods A community sample of 18-year-olds (N = 345) completed diagnostic interviews and EMA probing emotions
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Examining the association between prenatal and perinatal adversity and the psychotic experiences in childhood Psychol. Med. (IF 6.9) Pub Date : 2024-03-04 Lorna Staines, Niamh Dooley, Colm Healy, Ian Kelleher, David Cotter, Mary Cannon
Background Prenatal and perinatal complications are established risk factors for psychotic disorder, but far less is known about these measures and psychotic experiences (PEs). We investigated the longitudinal effect of prenatal risk factors (maternal behavior, medication complications) and perinatal risk factors (birth weight, medical complications) on frequency of PEs. We also examined the cumulative
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External cues improve visual working memory encoding in the presence of salient distractors in schizophrenia Psychol. Med. (IF 6.9) Pub Date : 2024-03-04 Catherine V. Barnes-Scheufler, Lara Rösler, Michael Schaum, Carmen Schiweck, Benjamin Peters, Jutta S. Mayer, Andreas Reif, Michael Wibral, Robert A. Bittner
Background People with schizophrenia (PSZ) are impaired in attentional prioritization of non-salient but relevant stimuli over salient distractors during visual working memory (VWM) encoding. Conversely, guidance of top–down attention by external predictive cues is intact. Yet, it is unknown whether this preserved ability can help PSZ encode more information in the presence of salient distractors.
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Models of mild cognitive deficits in risk assessment in early psychosis Psychol. Med. (IF 6.9) Pub Date : 2024-03-04 TianHong Zhang, HuiRu Cui, XiaoChen Tang, LiHua Xu, YanYan Wei, YeGang Hu, YingYing Tang, ZiXuan Wang, HaiChun Liu, Tao Chen, ChunBo Li, JiJun Wang
Background Mild cognitive deficits (MCD) emerge before the first episode of psychosis (FEP) and persist in the clinical high-risk (CHR) stage. This study aims to refine risk prediction by developing MCD models optimized for specific early psychosis stages and target populations. Methods A comprehensive neuropsychological battery assessed 1059 individuals with FEP, 794 CHR, and 774 matched healthy controls
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Environmental risk factors for schizophrenia and bipolar disorder from childhood to diagnosis: a Swedish nested case–control study Psychol. Med. (IF 6.9) Pub Date : 2024-03-01 Natassia Robinson, Alexander Ploner, Marica Leone, Paul Lichtenstein, Kenneth S. Kendler, Sarah E. Bergen
Background: Shared genetic risk between schizophrenia (SCZ) and bipolar disorder (BD) is well-established, yet the extent to which they share environmental risk factors remains unclear. We compare the associations between environmental exposures during childhood/prior to disorder onset with the risk of developing SCZ and BD. Methods: We conducted a Swedish register-based nested case–control study using
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Changes in evening-shifted loss of control eating severity following treatment for binge-eating disorder Psychol. Med. (IF 6.9) Pub Date : 2024-02-28 Angeline R. Bottera, Elizabeth N. Dougherty, Glen Forester, Carol B. Peterson, Ross D. Crosby, Scott G. Engel, Scott J. Crow, Jennifer E. Wildes, Stephen A. Wonderlich
Background Loss of control eating is more likely to occur in the evening and is uniquely associated with distress. No studies have examined the effect of treatment on within-day timing of loss of control eating severity. We examined whether time of day differentially predicted loss of control eating severity at baseline (i.e. pretreatment), end-of-treatment, and 6-month follow-up for individuals with
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Transdiagnostic dimensions of symptoms and experiences associated with immune proteins in the continuity of psychosis Psychol. Med. (IF 6.9) Pub Date : 2024-02-28 Fabiana Corsi-Zuelli, Diego Quattrone, Taciana Cristina Carvalho Ragazzi, Camila Marcelino Loureiro, Rosana Shuhama, Paulo Rossi Menezes, Paulo Louzada-Junior, Cristina Marta Del-Ben
Background There is limited evidence as to whether the immune protein profile is associated with a particular symptomatology pattern across the psychosis continuum. Methods We estimated two bifactor models of general and specific dimensions of psychotic experiences in unaffected siblings of patients (n = 52) and community controls (n = 200), and of psychotic symptoms in first-episode psychosis (FEP)
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Endocannabinoid levels in plasma and neurotransmitters in the brain: a preliminary report on patients with a psychotic disorder and healthy individuals Psychol. Med. (IF 6.9) Pub Date : 2024-02-23 Carmen F. M. van Hooijdonk, Michiel G. J. Balvers, Marieke van der Pluijm, Charlotte L. C. Smith, Lieuwe de Haan, Anouk Schrantee, Maqsood Yaqub, Renger F. Witkamp, Elsmarieke van de Giessen, Therese A. M. J. van Amelsvoort, Jan Booij, Jean-Paul Selten
Background Interactions between the endocannabinoid system (ECS) and neurotransmitter systems might mediate the risk of developing a schizophrenia spectrum disorder (SSD). Consequently, we investigated in patients with SSD and healthy controls (HC) the relations between (1) plasma concentrations of two prototypical endocannabinoids (N-arachidonoylethanolamine [anandamide] and 2-arachidonoylglycerol
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A good life with psychosis: rate of positive outcomes in first-episode psychosis at 10-year follow-up Psychol. Med. (IF 6.9) Pub Date : 2024-02-23 Carmen Simonsen, Gina Åsbø, Mike Slade, Kristin Fjelnseth Wold, Line Widing, Camilla Bärthel Flaaten, Magnus Johan Engen, Siv Hege Lyngstad, Erlend Gardsjord, Thomas Bjella, Kristin Lie Romm, Torill Ueland, Ingrid Melle
Background More knowledge about positive outcomes for people with first-episode psychosis (FEP) is needed. An FEP 10-year follow-up study investigated the rate of personal recovery, emotional wellbeing, and clinical recovery in the total sample and between psychotic bipolar spectrum disorders (BD) and schizophrenia spectrum disorders (SZ); and how these positive outcomes overlap. Methods FEP participants
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The association between neighborhood-level social fragmentation and distressing psychotic-like experiences in early adolescence: the moderating role of close friends Psychol. Med. (IF 6.9) Pub Date : 2024-02-16 Benson S. Ku, Jiyuan Ren, Michael T. Compton, Benjamin G. Druss, Shuyi Guo, Elaine F. Walker
Background Early exposure to neighborhood social fragmentation has been shown to be associated with schizophrenia. The impact of social fragmentation and friendships on distressing psychotic-like experiences (PLE) remains unknown. We investigate the relationships between neighborhood social fragmentation, number of friends, and distressing PLE among early adolescents. Methods Data were collected from
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Frequency-dependent alterations of global signal topography in patients with major depressive disorder Psychol. Med. (IF 6.9) Pub Date : 2024-02-16 Chengxiao Yang, Bharat Biswal, Qian Cui, Xiujuan Jing, Yujia Ao, Yifeng Wang
Background Major depressive disorder (MDD) is associated not only with disorders in multiple brain networks but also with frequency-specific brain activities. The abnormality of spatiotemporal networks in patients with MDD remains largely unclear. Methods We investigated the alterations of the global spatiotemporal network in MDD patients using a large-sample multicenter resting-state functional magnetic
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The genetic epidemiology of schizotypal personality disorder Psychol. Med. (IF 6.9) Pub Date : 2024-02-16 Kenneth S. Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
Background The concept of schizotypal personality disorder (SPD) emerged from observations of personality characteristics common in relatives of schizophrenic patients. While often studied in family designs, few studies and none with genetic measures, have examined SPD in epidemiological samples. Methods We studied individuals born in Sweden 1940–2000 with an ICD-10 diagnosis of SPD with no prior schizophrenia
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Enlarged pituitary gland volume: a possible state rather than trait marker of psychotic disorders Psychol. Med. (IF 6.9) Pub Date : 2024-02-15 Synthia Guimond, Ahmad Alftieh, Gabriel A. Devenyi, Luke Mike, M. Mallar Chakravarty, Jai L. Shah, David A. Parker, John A. Sweeney, Godfrey Pearlson, Brett A. Clementz, Carol A. Tamminga, Matcheri Keshavan
Background Enlarged pituitary gland volume could be a marker of psychotic disorders. However, previous studies report conflicting results. To better understand the role of the pituitary gland in psychosis, we examined a large transdiagnostic sample of individuals with psychotic disorders. Methods The study included 751 participants (174 with schizophrenia, 114 with schizoaffective disorder, 167 with
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A randomized controlled trial of a digital cognitive-behavioral therapy program (COMPASS) for managing depression and anxiety related to living with a long-term physical health condition Psychol. Med. (IF 6.9) Pub Date : 2024-02-14 Federica Picariello, Katrin Hulme, Natasha Seaton, Joanna L Hudson, Sam Norton, Abigail Wroe, Rona Moss-Morris
Background To evaluate the clinical efficacy of COMPASS, a therapist-supported digital therapeutic for reducing psychological distress (anxiety/depression) in people living with long-term physical health conditions (LTCs).Methods A two-armed randomized-controlled trial recruiting from LTC charities. Participants with anxiety and/or depression symptoms related to their LTC(s) were randomized (concealed
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Interplay of polygenic liability with birth-related, somatic, and psychosocial factors in anorexia nervosa risk: a nationwide study Psychol. Med. (IF 6.9) Pub Date : 2024-02-13 Natalie M. Papini, Emily Presseller, Cynthia M. Bulik, Katrine Holde, Janne T. Larsen, Laura M. Thornton, Clara Albiñana, Bjarni J. Vilhjálmsson, Preben B. Mortensen, Zeynep Yilmaz, Liselotte V. Petersen
Background Although several types of risk factors for anorexia nervosa (AN) have been identified, including birth-related factors, somatic, and psychosocial risk factors, their interplay with genetic susceptibility remains unclear. Genetic and epidemiological interplay in AN risk were examined using data from Danish nationwide registers. AN polygenic risk score (PRS) and risk factor associations, confounding
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20-year neurocognitive development following a schizophrenia spectrum disorder and associations with symptom severity and functional outcomes Psychol. Med. (IF 6.9) Pub Date : 2024-02-12 Marie Starzer, Helene Gjervig Hansen, Carsten Hjorthøj, Nikolai Albert, Kathryn E. Lewandowski, Louise Birkedal Glenthøj, Merete Nordentoft
Background Cognitive deficits are a core feature of schizophrenia and are closely associated with poor functional outcomes. It remains unclear if cognitive deficits progress over time or remain stable. Determining patients at increased risk of progressive worsening might help targeted neurocognitive remediation approaches. Methods This 20-year follow-up study examined neurocognitive outcomes of 156
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Age dependent effects of early intervention in borderline personality disorder in adolescents Psychol. Med. (IF 6.9) Pub Date : 2024-02-12 Michael Kaess, Madelyn Thomson, Stefan Lerch, Julian Koenig, Gloria Fischer-Waldschmidt, Corinna Reichl, Marialuisa Cavelti
Background Psychological treatments for young people with sub-threshold or full-syndrome borderline personality disorder (BPD) are found to be effective. However, little is known about the age at which adolescents benefit from early intervention. This study investigated whether age affects the effectiveness of early intervention for BPD. Methods N = 626 participants (M age = 15 years, 82.7% female)
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Higher emotion regulation flexibility predicts more stable negative emotions and faster affective recovery in early psychosis: an experience sampling study Psychol. Med. (IF 6.9) Pub Date : 2024-02-12 Xu Li, Thomas Vaessen, Ginette Lafit, Evelyne van Aubel, Anu P. Hiekkaranta, Marlies Houben, Annelie Beijer-Klippel, Lieuwe de Haan, Frederike Schirmbeck, Ulrich Reininghaus, Inez Myin-Germeys
Background While evidence shows that people with early psychosis are flexible in using different emotion regulation (ER) strategies to manage the varying contextual demands, no studies have examined the effectiveness of such regulatory flexibility in this population. We addressed this issue by investigating whether and how ER flexibility relate to different dynamic aspects (variability, instability
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Genetic and non-genetic predictors of risk for opioid dependence Psychol. Med. (IF 6.9) Pub Date : 2024-02-06 Peter J. Na, Joseph D. Deak, Henry R. Kranzler, Robert H. Pietrzak, Joel Gelernter
Background Elucidation of the interaction of biological and psychosocial/environmental factors on opioid dependence (OD) risk can inform our understanding of the etiology of OD. We examined the role of psychosocial/environmental factors in moderating polygenic risk for opioid use disorder (OUD). Methods Data from 1958 European ancestry adults who participated in the Yale-Penn 3 study were analyzed
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Association of psychiatric disorders with clinical diagnosis of long COVID in US veterans Psychol. Med. (IF 6.9) Pub Date : 2024-02-05 Kristen Nishimi, Thomas C. Neylan, Daniel Bertenthal, Karen H. Seal, Aoife O'Donovan
Background Psychiatric disorders may be a risk factor for long COVID, broadly defined as COVID-19 conditions continuing three months post-acute infection. In US Veterans with high psychiatric burden, we examined associations between psychiatric disorders and clinical diagnosis of long COVID. Methods We conducted a retrospective cohort study using health records from VA patients with a positive SARS-CoV-2
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Cross-cultural validation of the revised Green et al., paranoid thoughts scale Psychol. Med. (IF 6.9) Pub Date : 2024-02-05 Björn Schlier, Tania M. Lincoln, Jessica L. Kingston, Suzanne H. So, Brandon A. Gaudiano, Eric M. J. Morris, Lyn Ellett
Background With efforts increasing worldwide to understand and treat paranoia, there is a pressing need for cross-culturally valid assessments of paranoid beliefs. The recently developed Revised Green et al., Paranoid Thoughts Scale (R-GPTS) constitutes an easy to administer self-report assessment of mild ideas of reference and more severe persecutory thoughts. Moreover, it comes with clinical cut-offs
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Longitudinal study of peer victimization, social support, and mental health during early adolescence Psychol. Med. (IF 6.9) Pub Date : 2024-02-05 Matías Martínez, Katherine S. Damme, Teresa Vargas, Beiming Yang, D. J. Rompilla, Jacquelyn Stephens, Yang Qu, Vijay A. Mittal, Claudia M. Haase
Background Peer victimization predicts the development of mental health symptoms in the transition to adolescence, but it is unclear whether and how parents and school environments can buffer this link. Methods We analyzed two-year longitudinal data from the Adolescent Brain Cognitive Development (ABCD) study, involving a diverse sample of 11 844 children across the United States (average at baseline
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The predictive effect of family genetic risk scores as an indirect measure of causal effects of one disorder on another Psychol. Med. (IF 6.9) Pub Date : 2024-02-05 Kenneth S. Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
Background One potential cause of comorbidity is the direct causal effect of one disorder – A – on risk for subsequent onset of disorder B. Could genetic risk scores be utilized to test for such an effect? If disorder A causally impacts on risk for disorder B, then genetic risk for disorder A should be lower in cases of disorder A with v. without a prior onset of B. Methods In all individuals (n =
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Screen time, brain network development and socio-emotional competence in childhood: moderation of associations by parent–child reading Psychol. Med. (IF 6.9) Pub Date : 2024-02-05 Pei Huang, Shi Yu Chan, Zhen Ming Ngoh, Zi Yan Ong, Xi Zhen Low, Evelyn C. Law, Peter D. Gluckman, Michelle Z.L. Kee, Marielle V. Fortier, Yap Seng Chong, Juan H. Zhou, Michael J. Meaney, Ai Peng Tan
Background Screen time in infancy is linked to changes in social-emotional development but the pathway underlying this association remains unknown. We aim to provide mechanistic insights into this association using brain network topology and to examine the potential role of parent–child reading in mitigating the effects of screen time. Methods We examined the association of screen time on brain network
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Social cognition and social motivation in schizophrenia and bipolar disorder: are impairments linked to the disorder or to being socially isolated? Psychol. Med. (IF 6.9) Pub Date : 2024-02-05 Michael F. Green, Jonathan K. Wynn, Naomi I. Eisenberger, William P. Horan, Junghee Lee, Amanda McCleery, David J. Miklowitz, Eric A. Reavis, L. Felice Reddy
Background People with schizophrenia on average are more socially isolated, lonelier, have more social cognitive impairment, and are less socially motivated than healthy individuals. People with bipolar disorder also have social isolation, though typically less than that seen in schizophrenia. We aimed to disentangle whether the social cognitive and social motivation impairments observed in schizophrenia
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Depression is associated with blunted affective responses to naturalistic reward prediction errors Psychol. Med. (IF 6.9) Pub Date : 2024-02-02 William J Villano, Aaron S Heller
Background Depression is characterized by abnormalities in emotional processing, but the specific drivers of such emotional abnormalities are unknown. Computational work indicates that both surprising outcomes (prediction errors; PEs) and outcomes (values) themselves drive emotional responses, but neither has been consistently linked to affective disturbances in depression. As a result, the computational
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The interaction between early life complications and a polygenic risk score for schizophrenia is associated with brain activity during emotion processing in healthy participants Psychol. Med. (IF 6.9) Pub Date : 2024-02-02 Veronica Debora Toro, Linda A. Antonucci, Tiziana Quarto, Roberta Passiatore, Leonardo Fazio, Gianluca Ursini, Qiang Chen, Rita Masellis, Silvia Torretta, Leonardo Sportelli, Gianluca Christos Kikidis, Francesco Massari, Enrico D'Ambrosio, Antonio Rampino, Giulio Pergola, Daniel R. Weinberger, Alessandro Bertolino, Giuseppe Blasi
Background Previous evidence suggests that early life complications (ELCs) interact with polygenic risk for schizophrenia (SCZ) in increasing risk for the disease. However, no studies have investigated this interaction on neurobiological phenotypes. Among those, anomalous emotion-related brain activity has been reported in SCZ, even if evidence of its link with SCZ-related genetic risk is not solid
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Clarifying directional dependence among measures of early auditory processing and cognition in schizophrenia: leveraging Gaussian graphical models and Bayesian networks Psychol. Med. (IF 6.9) Pub Date : 2024-01-30 Samuel J. Abplanalp, David L. Braff, Gregory A. Light, Yash B. Joshi, Keith H. Nuechterlein, Michael F. Green
Background Research using latent variable models demonstrates that pre-attentive measures of early auditory processing (EAP) and cognition may initiate a cascading effect on daily functioning in schizophrenia. However, such models fail to account for relationships among individual measures of cognition and EAP, thereby limiting their utility. Hence, EAP and cognition may function as complementary and
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Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study Psychol. Med. (IF 6.9) Pub Date : 2024-01-30 Giuseppe D'Andrea, Diego Quattrone, Kathryn Malone, Giada Tripoli, Giulia Trotta, Edoardo Spinazzola, Charlotte Gayer-Anderson, Hannah E Jongsma, Lucia Sideli, Simona A Stilo, Caterina La Cascia, Laura Ferraro, Antonio Lasalvia, Sarah Tosato, Andrea Tortelli, Eva Velthorst, Lieuwe de Haan, Pierre-Michel Llorca, Paulo Rossi Menezes, Jose Luis Santos, Manuel Arrojo, Julio Bobes, Julio Sanjuán, Miguel
Background Incidence of first-episode psychosis (FEP) varies substantially across geographic regions. Phenotypes of subclinical psychosis (SP), such as psychotic-like experiences (PLEs) and schizotypy, present several similarities with psychosis. We aimed to examine whether SP measures varied across different sites and whether this variation was comparable with FEP incidence within the same areas.
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Is trait rumination associated with affective reactivity to the menstrual cycle? A prospective analysis Psychol. Med. (IF 6.9) Pub Date : 2024-01-29 Hafsah A. Tauseef, Katja M. Schmalenberger, Jordan C. Barone, Jaclyn M. Ross, Jessica R. Peters, Susan S. Girdler, Tory A. Eisenlohr-Moul
Background A minority of naturally cycling individuals experience clinically significant affective changes across the menstrual cycle. However, few studies have examined cognitive and behavioral constructs that may maintain or worsen these changes. Several small studies link rumination with premenstrual negative affect, with authors concluding that a tendency to ruminate amplifies and perpetuates hormone-sensitive
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Limited evidence of autocorrelation signaling upcoming affective episodes: a 12-month e-diary study in patients with bipolar disorder Psychol. Med. (IF 6.9) Pub Date : 2024-01-29 V. M. Ludwig, I. Reinhard, E. Mühlbauer, H. Hill, W. E. Severus, M. Bauer, P. Ritter, U. W. Ebner-Priemer
Background Increased autocorrelation (AR) of system-specific measures has been suggested as a predictor for critical transitions in complex systems. Increased AR of mood scores has been reported to anticipate depressive episodes in major depressive disorder, while other studies found AR increases to be associated with depressive episodes themselves. Data on AR in patients with bipolar disorders (BD)
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Assessing expectancy and suggestibility in a trial of escitalopram v. psilocybin for depression Psychol. Med. (IF 6.9) Pub Date : 2024-01-25 Balázs Szigeti, Brandon Weiss, Fernando E. Rosas, David Erritzoe, David Nutt, Robin Carhart-Harris
Background To investigate the association between pre-trial expectancy, suggestibility, and response to treatment in a trial of escitalopram and investigational drug, COMP360, psilocybin, in the treatment of major depressive disorder (ClinicalTrials.gov registration: NCT03429075). Methods We used data (n = 55) from our recent double-blind, parallel-group, randomized head-to-head comparison trial of
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Psychiatric in-patient care in England: as safe as it can be? An examination of in-patient suicide between 2009 and 2020 Psychol. Med. (IF 6.9) Pub Date : 2024-01-12 Isabelle M. Hunt, Alison Baird, Pauline Turnbull, Saied Ibrahim, Jenny Shaw, Louis Appleby, Nav Kapur
Background Psychiatric in-patients have a greatly elevated risk of suicide. We aimed to examine trends in in-patient suicide rates and determine if characteristics of in-patients who died by suicide have changed over time. Methods We identified all in-patients in England who died by suicide between 2009 and 2020 from the National Confidential Inquiry into Suicide and Safety in Mental Health. Suicide
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The causal association between maternal depression, anxiety, and infection in pregnancy and neurodevelopmental disorders among 410 461 children: a population study using quasi-negative control cohorts and sibling analysis Psychol. Med. (IF 6.9) Pub Date : 2024-01-11 Holly Hope, Matthias Pierce, Hend Gabr, Maja R. Radojčić, Eleanor Swift, Vicky P. Taxiarchi, Kathryn M. Abel
Background To address if the long-standing association between maternal infection, depression/anxiety in pregnancy, and offspring neurodevelopmental disorder (NDD) is causal, we conducted two negative-control studies. Methods Four primary care cohorts of UK children (pregnancy, 1 and 2 years prior to pregnancy, and siblings) born between 1 January 1990 and 31 December 2017 were constructed. NDD included
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Early life stress in relation with risk of overweight, depression, and their comorbidity across adulthood: findings from a British birth cohort Psychol. Med. (IF 6.9) Pub Date : 2024-01-10 Ainhoa Ugarteche Pérez, Eloïse Berger, Michelle Kelly-Irving, Cyrille Delpierre, Lucile Capuron, Raphaële Castagné
Background Multimorbidity, known as the co-occurrence of at least two chronic conditions, has become of increasing concern in the current context of ageing populations, though it affects all ages. Early life risk factors of multimorbidity include adverse childhood experiences (ACEs), particularly associated with psychological conditions and weight problems. Few studies have considered related mechanisms
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How does cognitive behavior therapy for dissociative seizures work? A mediation analysis of the CODES trial Psychol. Med. (IF 6.9) Pub Date : 2024-01-10 T. Chalder, S. Landau, J. Stone, A. Carson, M. Reuber, N. Medford, E. J. Robinson, L. H. Goldstein
Background We compared dissociative seizure specific cognitive behavior therapy (DS-CBT) plus standardized medical care (SMC) to SMC alone in a randomized controlled trial. DS-CBT resulted in better outcomes on several secondary trial outcome measures at the 12-month follow-up point. The purpose of this paper is to evaluate putative treatment mechanisms. Methods We carried out a secondary mediation
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Reward anticipation-related neural activation following cued reinforcement in adults with psychotic psychopathology and biological relatives Psychol. Med. (IF 6.9) Pub Date : 2024-01-10 Caroline Demro, Elijah Lahud, Philip C. Burton, John R. Purcell, Joe J. Simon, Scott R. Sponheim
Background Schizophrenia is associated with hypoactivation of reward sensitive brain areas during reward anticipation. However, it is unclear whether these neural functions are similarly impaired in other disorders with psychotic symptomatology or individuals with genetic liability for psychosis. If abnormalities in reward sensitive brain areas are shared across individuals with psychotic psychopathology
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The societal impact of individual placement and support implementation on employment outcomes for young adults receiving temporary health-related welfare benefits: a difference-in-differences study Psychol. Med. (IF 6.9) Pub Date : 2024-01-10 Beate Brinchmann, Sina Wittlund, Thomas Lorentzen, Cathrine Moe, David McDaid, Eoin Killackey, Miles Rinaldi, Arnstein Mykletun
Background Individual placement and support (IPS) is an evidence-based practice that helps individuals with mental illness gain and retain employment. IPS was implemented for young adults at a municipality level through a cross-sectoral collaboration between specialist mental healthcare, primary mental healthcare, and the government funded employment service (NAV). We investigated whether IPS implementation
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Disentangling pain and fatigue in chronic fatigue syndrome: a resting state connectivity study before and after cognitive behavioral therapy Psychol. Med. (IF 6.9) Pub Date : 2024-01-09 Marieke E. van der Schaaf, Linda Geerligs, Ivan Toni, Hans Knoop, Joukje M. Oosterman
Background Fatigue is a central feature of myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), but many ME/CFS patients also report comorbid pain symptoms. It remains unclear whether these symptoms are related to similar or dissociable brain networks. This study used resting-state fMRI to disentangle networks associated with fatigue and pain symptoms in ME/CFS patients, and to link changes