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A Review on Working Principle and Advanced Applications of Fluorescence activated Cell Sorting Machine (FACS) Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-03-15 Gurisha Garg, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi
: Various technologies, like flow cytometry and cell sorting, have been established in fields of biomedical research. Fluorescence-activated cell sorting is one of the most powerful techniques to witness advancement in these years. This article aims to provide an in-depth overview of the FACS applications, along with regulatory considerations and qualification parameters for the instrument. Moreover
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Enantioselective Recognition of Chiral Α-Phenylethanol by Β-Cyclodextrin and Characterization of its Inclusion Behaviour Based On 2D ROESY Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-03-12 Jian Chen, Qiulin Li, Yawen Yang, Liang Qi, Xiang Han, Nan Zhang, Bin Zheng, Fuxin Chen
Background:: α-phenylethanol and its derivatives are important intermediates for the synthesis of a variety of chiral drugs. Method:: The interaction mechanism of the two enantiomers of α-phenylethanol with β-CD was investigated using 1H-NMR and ROESY. The loading of β-cyclodextrin (β-CD) as the host with the chiral drug intermediate α-phenylethanol as the guest was investigated using high-resolution
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Bionanofactories for the Environmental Friendly Fabrication of Silver Nanoparticles: Application to the Analysis of Antimicrobial Agents Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-03-06 Shatrudhan Prajapati, Shikha Yadav, Javed Khan
: The green synthesis of silver nanoparticles has garnered significant interest because of the unique physicochemical and biological properties they possess. These nanoparticles could have applications in a wide variety of fields, including biomedicine, cellular imaging, cosmetics, healthcare tourism, food and agriculture. The formation of nanoparticles is facilitated by the use of bionanofactories
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Rapid Quantitation of Non-chromophoric Vigabatrin and Gabapentin by a Validated qNMR Method in Bulk Drug and Marketed Formulations Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-02-22 Pooja Bedage, Archana Sahu, Inder Pal Singh
Background:: Vigabatrin and gabapentin, commonly used antiepileptic drugs in clinics, lack a UV active chromophore and, therefore, require cumbersome derivatization methods for analysis by HPLC using fluorescence detection. This study demonstrated the use of NMR for their quantitative determination in pure form and their pharmaceutical formulations. Objective:: To develop a validated qNMR method for
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Pharmacokinetic Studies of Gypenoside XLVI in Rat Plasma using UPLC-MS/MS Method Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-01-29 Han Li, Aiping Yang, Meng Yang, Fengjuan Zhou, Rui Zhang, Zongping Zheng, Xiachang Wang
Background: Gynostemma pentaphyllum (Thunb.) Makino has been linked to a numbers of pharmacological benefits, including hepatoprotective, anti-inflammatory, antioxidative, and antihyperlipidemic activities. Gypenoside XLVI (Gyp XLVI) was a significant triterpenoid saponin reported from a sweet-taste varietas G. pentaphyllum, which has inhibitory effects and causes apoptosis on human hepatocytes and
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Determination of Ketamine, Fluoroketamine, Norketamine, and 2-Norfluoro-ketamine in Urine using Ultra-performance Liquid Chromatography-tandem Mass Spectrometry Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-01-25 Meiling Zhang, Xicheng Dong, Wanhang Wang, Ziyue Wang, Dizhong Chen, Congcong Wen, Xianqin Wang
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Isocratic RP-HPLC Method Development, Validation, and Optimization of BCS-II in Bulk and Dosage Form Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-01-25 Uditi Handa, Anuj Malik, Kumar Guarve, Fatimah Jan, Kajal Nagpal
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Formulation, Analytical Method Development and Validation of an Emulsion of Multi-enzyme with Carminative Oils Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-01-25 Amitava Kabiraj, Rohitas Deshmukh
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Determination of Tyrosine Kinase Inhibitor Icotinib in Rat Plasma using UPLC-MS/MS and its Application In vivo Pharmacokinetic Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-01-25 Xuewei Zhao, Ruoyang Li, Zhangying Feng, Shanshan Chen, Yu Liang, Jinglin Gao, Mingxia Wang
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Molecular Absorption Scanning and Assay of Serotonin Reception Inhibitor Antidepressant Drugs Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-01-16 Amanda Santana Silva, Victor Hugo Abreu de Paula, Lucas Gabriel dos Santos Xavier, Ludimila Nascimento da Silva, Ana Carolyne Silva Lucas, Aléxia Mariany Lourenço Alves, Fernando Machado dos Santos
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Quality Evaluation of Banlangen Granule based on Bioassays of Anti-influenzal and Anti-inflammatory Effects Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-01-16 Xiu-yu Qian, Ming-lu Zhang, Yan-Lin Wu, Shuang-cheng Ma, Jin-mei Liu, Yan-hui Kuang, Li-xing Nie
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A Review on N-nitrosamine Impurity Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-01-16 Debangana Pal, Babu B.
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Evaluation of the Quality of Water Samples Purified by Compounding Pharmacies in Brazil Curr. Pharm. Anal. (IF 0.6) Pub Date : 2024-01-08 Lucas Prosperi Ferreira, Marcus Vinicius Martins Rubatino, Magali Benjamin de Araújo, Rudy Bonfilio
Background: Highly purified water is essential for the production of pharmaceuticals, directly impacting the quality and safety of the final product. Methods: In this work, we studied the physicochemical and microbiological quality of 1477 purified water samples from 25 compounding pharmacies in Southeast Brazil. To the best of our knowledge, this is the most comprehensive study on the quality of water
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Stability Indicating HPLC Method for In-Vitro Determination of Pantoprazole Sodium and its Degradation Products in Simulated Gastric and Intestinal Fluids Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-12-15 Avani Gupta, Juber Akhtar, Kailash Chandra Rastogi, Badruddeen, Mohammad Irfan Khan, Mohammad Ahmad
Background: A high-performance liquid chromatography (HPLC) method was developed for the determination of Pantoprazole Sodium (PPZ) in the presence of its degradation products. The degradation of PPZ was studied in simulated intestinal fluid (SIF) and simulated gastric fluids (SGF) in various temperature conditions. Aim: This study aimed to establish a simple, sensitive, and rapid RP HPLC method for
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Improved Detection of Veterinary Drug Residues: Advancing Analytical Techniques to Ensure Food Safety Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-12-14 Li Fu, Jiangwei Zhu, Qingwei Zhou
Veterinary drug residues in foods pose risks to consumers and promote antimicrobial resistance. Effective detection methods are needed to monitor and control residues. Recent advancements in analytical techniques for veterinary drug residue detection were reviewed. Key sample preparation methods, including QuEChERS, SPE, ASE, and LLE, were summarized. Instrumental analysis techniques including LC-MS/MS
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Development and Validation of an Analytical RP-HPLC Method for Simultaneous Estimation of Losartan and its Active Metabolite (EXP-3174) in Isolated Perfused Rat Liver Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-12-06 Mahsa Toolabi, Reyhaneh Ramezankhani, Nadereh Rahbar, Maryam Dibaei, Alireza foroumadi, Hoda Lavasani, Vida Kazemi, Mohammadreza Rouini
Background: The liver perfusion method is frequently used in drug pharmacokinetic studies and the various effects of drugs on liver tissue. The aim of this study was to establish and validate an analytical method using high-performance liquid chromatography to determine the simultaneous concentration of losartan and its active metabolite, EXP-3174, in an isolated perfused rat liver study. Method: An
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Development and Validation of Simultaneous Quantitative Dissolution Analysis for the Two Active Pharmaceutical Ingredients in Dapagliflozin Propanediol Monohydrate–Sitagliptin Phosphate Monohydrate Multi-Layered Tablets Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-12-01 Ji-Hye Shin, Joo-Eun Kim
Background: Recently, a combination prescription with the main ingredients sitagliptin and dapagliflozin as dipeptidyl peptidase-4 andsodium–glucose cotransporter-2 inhibitors, respectively, for the treatment of type 2 diabetes has widely been issued in hospitals. However, the development of double-layered tablets requires simultaneous quantitative dissolution tests that are significantly efficient
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Protein Species of Origin Determination By NMR Relaxometry Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-11-15 Gregory K. Webster
Aims: The aim of this project was to develop a QC friendly and efficient method of protein species of origin identification to replace more costly mass spectrometric based methods currently being used for this testing. Background: NMR relaxation measurements with proteins in aqueous solutions exploit the fast chemical exchange between water and exposed NH and OH protons of amino acid side chains in
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The Metabolism Study of Oleraisoquinoline in Rats Using Ultrahigh- performance Liquid Chromatography-electrospray Coupled with Quadrupole Time-of-flight Mass Spectrometry and its Bioactivities Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-11-07 Peishan Liu, Rui Sun, Jiayin Tian, Fan He, Xixiang Ying
Objective: This study aimed to investigate the main metabolites and metabolic pathways of oleraisoquinoline in rats, a new alkaloid isolated from Portulaca oleracea L., and test its antioxidation and anticholinesterase effects. Methods: Ultra-high-performance liquid chromatography-electrospray coupled with quadrupole time-of-flight mass spectrometry (UHPLC-ESI-Q-TOF/MS) was applied to study the metabolism
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Comprehensive Review on Analytical and Bioanalytical Methods for Quantification of Anti-Angiogenetic Agents used in Treatment of Cervical Cancer Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-11-08 Parikh Nisha, Parmar Srushti, Dave Bhavarth, Mohammad Kaif, Parikh Palak
Cervical cancer is one of the most prevalent forms of cancer occurring across the world and it has been observed that about 99.7% of cervical cancer cases occur due to infections with the Human papillomavirus (HPV). Over prolonged durations, cervical cancer can lead to complications such as vaginal bleeding, itching, and in more severe instances, even the fatality of the individual. Cervical cancer
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Application of the Different Analytical Methods for Non-chromophoric Pharmaceutical Compounds Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-11-08 Neha Singh, Sumit Pannu, Karanvir Singh, Md Jawaid Akhtar, Ankit Anchliya, Shah Alam Khan
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A Rapid and Sensitive UPLC-MS/MS Method for the Determination of Bellidifolin and Pharmacokinetics Study of Bellidifolin Nano-microcells Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-10-20 Jiaye Tian, Ran Bai, Ziyue Chen, Piaoran Qin, Xingchao Liu, Haoran Shen, Li Zhou, Qiuhong Guo
Background: Bellidifolin (BEL) has a decent enemy of myocardial fibrosis impact, and its preparation into nano-micelles can build security and great biocompatibility in vitro and in vivo. The pharmacokinetic assessment of BEL can be utilized as the reason for the security and viability of BEL in clinical use. Objective: This research aimed to establish an effective UPLC-MS/MS strategy for assuring
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Explore the Constituents and Mechanism of Traditional Chinese Medicine Preparation Zhachong Shisan Pills Based on HPLC-QTOF-MS and Network Pharmacology Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-10-18 Yueqiang Xin, Yuli Sang, Xiang Ji, Manman Tang, Lijiang Chen, Yanjun Hao, Jing Lu
Introduction: Th study aims to establish the chromatographic fingerprint of Zhachong Shisan pills (ZSP), and to explore its active components and mechanism of analgesic and anti-inflammatory action. Method: First, the Personal Compound Database and Library (PCDL) of ZSP was constructed through literature mining, and then the chemical composition and fingerprint of methanol extractions from 8 batches
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Spectroscopic and Chromatographic Estimation of Some Sartans and their Combinations with Thiazide Diuretics: A Review Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-10-06 Kajal P. Baviskar, Ramanlal N. Kachave
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Comparison of ZIC-HILIC Columns for the Simultaneous Analysis of Antiviral Drugs in Dosage Forms by Hydrophilic Interaction Liquid Chromatography Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-10-05 Sohair Salah Ahmed, Ashraf Saad Rasheed
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Method Validation and Monitoring of N-nitrosodimethylamine in Metformin Hydrochloride Products in China by GC-MS/MS Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-10-04 Jia-jia Zou, Lin Yang, Xiao-li Xu, Yan Li, Dan He
Background: N-nitrosodimethylamine (NDMA) are a sort of genotoxic impurities (GTIs) having strong carcinogenic effects and obvious hepatotoxicity. To monitor the NDMA content of metformin hydrochloride sustained-release tablets and enteric capsules in China from 2018 to 2022, a GC-MS/MS method was established and validated. Materials and Methods: The chromatographic column was Agilent VF-WAXms capillary
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Development of Simple HPLC-UV Method for the Simultaneous Determination of Repaglinide, Dexamethasone, and Remdesivir, and its Application to Synthetic Mixture and Human Plasma Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-10-03 Miglena Smerikarova, Stanislav Bozhanov, Alexandrina Mateeva, Vania Maslarska
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Analytical Methodologies for the Estimation of Acyclovir as Key Members of Anti-viral Agent: Two Decades in Review Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-09-15 Akhil Gupta, Shilpi Pathak
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Quality by Design (QbD): A Comprehensive Understanding and Implementation in Pharmaceuticals Development Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-09-14 Sarita S. Pawar, Yash S. Mahale, Prachi A. Kalamkar, Rohini A. Satdive, Sujata K. Sonawane, Sneha P. Bhapkar
Quality by Design (QbD) is a systematic approach for improvement that stresses product and process and begins with a predetermined objective, as recommended by the USFDA and International Council Harmonization (ICH). Regulatory bodies frequently highlight the use of ICH quality criteria, which include Q8, Q9, Q10, and Q11. The differentiation between the traditional and QbD helps to study the risk
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Pharmacokinetics Study and Simultaneous Quantification of Eight Schisandra Lignans in Normal Rats by LC-MS/MS after Oral Administration of Schisandra Lignan Extract Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-09-14 Yan Yu, Yongduo Yu, Zhenqi Wu, Shiyu Zhang
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Novel “HYDALJSS08” Hydroalcoholic Polyherbal Formulation Development and Ultra-performance Liquid Chromatographic Separation, Estimation of Andrographolides in Andrographis paniculata whole Plants and a Marketed Siddha-based Polyherbal Formulation “Kabusura Kudineer” Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-09-08 Ramkishan Jatoth, Dhanabal S.P, Venkatachalam Senthil, Thangavel Ganesh, Jubie Selvaraj, Jeyprakash. M.R., Duraiswamy Basavan
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A Diagnostic Tool for Good Chromatographic Practices Applied to HPLC in Pharmaceutical Quality Control Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-08-29 Rodolpho Guilherme Menezes Gama, Aline de Souza Ramos, Ana Claudia Fernandes Amaral
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Development and Validation of In-vitro Release Study of Molnupiravir Capsules by RP-HPLC Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-08-28 Shipra Singhal, Aman Sharma, Anirudh Malik, Meenakshi Dahiya, Gaurav Pratap Singh Jadaun, Vaishali M. Patil, Shikha Kaushik
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Application of a Quantitative Proton Nuclear Magnetic Resonance Method for the Determination of Protopine in Radix Dactylicapnotis Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-08-25 Xue-Jiao Li, Jian-Wei Dong, Zheng-Fen Liu, Jun-You Shi, Feng-Mei Zhang, Yan-Mei Fa, Ya-Li Li, Xue-Xian Wang
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Extraction and Analysis of Lipid Raft Proteins with Detergent-and Non detergent-based Method Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-08-24 Yuchu Chen, Hongbei Liu, Adu-Frimpong Michael, Chenlu Gu, Lu Zhao, Sheng Tian, Xiu Li, Xia Cao, Shanshan Tong
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Identification of Methamphetamine and Amphetamine in Drug Abuse Urine Sample using Multi-drug Rapid Test and Gas Chromatography- Mass Spectrometry (GC-MS) at the Centre of Drug Testing Laboratory, National Narcotics Board Republic of Indonesia Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-08-10 Kurnia Sandy, Tesia Aisyah Rahmania, Eri Arfiyani
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Advancements in the Analytical Methods for Ripasudil Hydrochloride Hydrate and Timolol Maleate: A Recently Approved FDC Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-08-08 Khushbu Patel, Rajendra Kotadiya
Fixed-dose Combinations (FDCs) combine two or more medications into a single dosage form. Several benefits, including impending therapeutic efficacy, a decline in episodes of adverse drug effects, pharmacokinetic advantages, a decrease in pill burden, a reduction in the dose of individual medications, and a reduction in the emergence of drug resistance, justify their acceptance. For the treatment of
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Researches on Detection of Related Substances in Drugs Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-08-01 Jianzhong Qi, Hongli Wang, Lu Dai, Lei Shi, Yanjun Hao, Haigang Chen
The production of drugs is very complicated. In the process of preparation and transportation, mixing a small amount of reaction raw materials, intermediates, and storage degradation products is inevitable, which affect the quality of drugs. The quality of drugs not only affects the efficacy, but also produces unpredictable side effects and toxicity, which is directly related to people's life and health
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Use of Chemical Reagents in Non-fluorescent Pharmaceutical Labels: A Comprehensive Review Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-07-12 Barla Karuna Devi, Kuchana Madhavi, Swathi Naraparaju, Rajeshwari Deverakonda
Spectrofluorimetry is an analytical technique with high sensitivity, specificity, and simplicity, and is very economical. Drugs that lack native fluorescence are derivatized with reagents so that highly fluorescent compounds are formed that can be readily detected by spectrofluorimetry. There are different reagents such as 4-chloro-7-nitrobenz-2-oxa-1,3-diazole (NBD-Cl), N- methylnicotinamide chloride
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Determination of Two Potential Genotoxic Impurities in Crisaborole API by UPLC-MS/MS Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-06-27 Mengmeng Zhang, Qiaogen Zou
Background: Atopic dermatitis (AD) is an allergic skin disease that can be inherited. Crisaborole is a specific drug developed to deal with this disease. The compounds of 4-(4- Bromo-3-formyl-phenoxy)-benzonitrile and 4-(4-(4-bromo-3-formylphenoxy)-3- formylphenoxy) benzonitrile are the representative impurities in the synthesis of Crisaborole active pharmaceutical in gradient (API). Owing to the genotoxic
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Development of a Suitable HPLC Method for the Analysis of Impurities in Clorprenaline and Bromhexine Capsules and Identification of Unknown Impurities by 2D LC-Q-TOF MS Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-06-22 Yunfeng Shi, Liqin Lin, Qi Yao, Xiaojuan Ren, Fengmei Zhang
Background: Impurities may reduce antibacterial activity and affect clinical efficacy, However, there has been no report on the impurity of clorprenaline and bromhexine capsules. Objective: In order to determine the impurities in compound clorprenaline and bromhexine capsules. Methods: A new stability-indicating HPLC method was established. A Boston Green ODS column was used, and the UV detection was
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Pitfalls and Opportunities in the Execution of Quality by Design in Analytical Sciences Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-06-07 Prashant K. Chaturvedi, Kalyani H. Joshi, Shruti Chopra, Savita J. Tauro, Pintu B. Prajapati
Quality by Design (QbD) is a systematic approach integrated with quality risk management. It uses different design approaches followed by statistical analysis to yield a quality product. Now, the pharmaceutical industries are intrested in the application of QbD principles to analytical methods and term it as Analytical QbD (AQbD), which does not essentially mean less analytical testing; to a particular
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Determination of Antithyroid Drug Propylthiouracil with Ru (III) in Pharmaceutical Formulations and its Characterization Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-06-05 Mukul Sharma, Afraim Koty
Background: Sulfur serves as a versatile element and an essential constituent of pharmaceutical industries, natural compounds, proteins, and biological systems. One of the fundamental constituents of sulfur is thiouracil, which forms several derivatives, including 6- methylthiouracil, 6-methyl-2-thiouracil, and 6-propylthiouracil. These derivatives act as effective chelating agents and can form complexes
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Review on Determination of Berberine in Biological and Pharmaceutical Matrices: An Analytical and Therapeutic Perspective Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-05-26 Umang Shah, Meghana Patel, Alkesh Patel, Krishna Patel, Mehul Patel, Ashok Akabari, Samir Patel, Veena Patel, Rajesh Maheshwari, Ashim Sen, Neeraj Kumar Sethiya
Berberine (BRB) is a natural alkaloid of the isoquinoline class, mostly isolated from the Berberis genus, which exhibits antibiotic, immunostimulant, antitumor, cardiovascular protection, endocrine regulator, antidepressant, neuroprotective, antioxidant, anti-inflammatory, and other pharmacological properties. The poor aqueous solubility of BRB is one roadblock in scaling up activities for the clinical
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An Overview of Analytical Methods for the Identification and Quantification of Baclofen Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-05-08 Milena Nogueira da Silva, João Victor Belo da Silva, Naara Felipe da Fonsêca, João Augusto Oshiro Junior, Ana Claudia Dantas Medeiros
Background: Baclofen is a potent antispasmodic agent, acting as an analgesic and central skeletal muscle relaxant. It is a GABA-B analog, and is widely used for the treatment of spasticity. Due to its therapeutic importance, various analytical techniques are used in the pharmaceutical industry and research to determine, identify, and characterize baclofen in bulk material, biological fluids, and pharmaceutical
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Experimental and Theoretical Study of Biosurfactants Functionalized Gold Nanoparticles for Mixture Detection and Chiral Recognition of Tryptophan by UV-VIS Spectroscopy Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-05-08 Xiangzong Wu, Yanxia Li, Yiting Chen, Zhenli Qiu, Lu Huang
Background: Tryptophan (Trp) is an essential amino acid and plays important roles in biological processes. The detection of Trp is very important for its biological and chemical study. Moreover, Trp is a chiral compound; due to its importance in biological processes, researchers have been long committed to the chiral recognition and sensing of Trp enantiomers. Methods: Two biosurfactants, sodium cholate
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The Development and Validation of Simultaneous Quantitative Analysis Reversed-phase High-performance Liquid Chromatography for Sitagliptin Phosphate Monohydrate and Dapagliflozin Propanediol Monohydrate Fixed-dose Combination Dual-layered Tablet Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-04-18 So-Jin Kang, Joo-Eun Kim
Background: Sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixeddose combination (FDC) dual-layered tablet is used for type 2 diabetes treatment. Simultaneous quantitative analysis can shorten the analysis time of sitagliptin phosphate monohydrate-dapagliflozin propanediol monohydrate FDC dual-layered tablets and increase their efficiency. Objective: This study aimed to develop
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A Review: Drug Excipient Iincompatiblity by Ftir Spectroscopy Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-04-17 Chander Singh, Komal Rao, Nikita Yadav, Nidhi Bansal, Yogesh Vashist, Shalini Kumari, Palak Chugh
For the development of various formulations, it is necessary to check out the drug excipient incompatibility. Whether the drug is compatible with the excipient or not. Because the drug excipient interaction study provides stability data of the drug and shelf life of the drug. Fourier transform infrared spectroscopy is the best method to evaluate the drug excipient incompatibility study. The FTIR spectroscopy
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Survey on Multi-omics, and Multi-omics Data Analysis, Integration and Application Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-04-10 Mohamad Hesam Shahrajabian, Wenli Sun
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Validation of the T-47D Cell Culture Bioassay for the Potency Assessment of Botulinum Neurotoxin Type A Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-04-04 Bruna Xavier, Rafaela Ferreira Perobelli Dumoncel, Clóvis Dervil Appratto Cardoso, Francielle Santos da Silva, Sérgio Luiz Dalmora
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Stability Study and Simultaneous Determination of Norepinephrine, Moxifloxacin, and Piperacillin + Tazobactam Mixtures Applied in Intensive Care Medicine Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-03-31 Jéssica Pires Schmidt, Martin Steppe
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Investigation of the Pharmacokinetic Properties and Theoretical Chemical Activities of 7,8-Dihydroxyflavone and 4'-Dimethylamino-7,8-Dihydroxyflavone Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-03-31 Muhammed Fatih Karakaya, Faik Gokalp, Erol Sener, Orhan Tansel Korkmaz
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The Metabolism of Portulacatone B from Portulaca oleracea L. in Rats by UHPLC-ESI-Q-TOF/MS Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-03-21 Xinyu Cui, Xiujuan Lan, Aijing Leng, Xixiang Ying
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Pharmacokinetics and Tissue Distribution Study of Daphnoretin in Ethanol Extract from the Roots of Wikstroemia Indica in Rats by a Validated UPLC-MS/MS Method Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-03-15 Wenjing Wang, Guo Feng, Lailai Li, Wei Li, Wen Liu, Zengguang Wu, Hongmei Su, Guanglin Zhu, Chenchen Ren, Xueli Song, Ju Zhang, Zhengyan He
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Establishment of HLB-UPLC-MS/MS Method to Determine Hainanmycin Sodium in Chicken Liver Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-03-13 Junjie Zhao, Linli Cheng, Yanan Chen, Kexin Chen, Yehui Luan
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Analysis of Organic Components in Various Butyl Rubber Closures and their Compatibility Study with Cefamandole Nafate by HPLC/GC-MS Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-02-27 Bingyong Xu, Jiarui Gao, Kaixian Tang, Fengmei Zhang, Shan Liu, Weike Su, Jian Wang
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Development and Application of Chitosan Nanogel as a Sorbent for Methotrexate Extraction Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-02-16 Sanaz Mehdi-Alamdarlou, Amir Azadi, Mojgan karbasian, Hajar Ashrafi
Background: Successful drug extraction from biological fluids is challenging due to interfering factors and the trace levels of the target analytes. Objective: We aimed to provide a suitable and sensitive method to increase the efficiency of methotrexate extraction from biological fluids. Methods: Chitosan-based nanogel synthesized by the ionic gelation method was used for solidphase microextraction
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Synthesis, Structure Confirmation of Deuterium-substituted Kynurenine and the Conformation Analysis of Kynurenine in Daptomycin Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-02-16 Hanzhi Zhang, Feng Qin, Ning Sun, Mengmeng Zheng, Wenyan Luo, Ya Qiu, Hao Liu, Xiangmin Zhang
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A Complete Roadmap of Analytical Quality by Design in Various Analytical Techniques Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-02-14 Mohana Krishnan Santhanam, Nalini Calamur Nagarajan, Poorna Basuri Ponraj, Mohamed Sameer Mohamed Hilurudeen
Background: For the development of robust analytical methods, Analytical-Qualityby- Design (AQbD)-based testing methods have been found to be more suited than other one factorial approaches. By creating a Method Operable Design Space, this strategy selects the optimal method conditions using the appropriate Design of Experiments. Objective: To impart knowledge to the researchers producing methods using
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A Critical Review on Smartphone Based Determinations of Drugs Curr. Pharm. Anal. (IF 0.6) Pub Date : 2023-02-07 Alankar Shrivastava
Cell phones are like a notepad PC with their own working framework, processor, interior memory, and top-notch camera focal points. Cell phones are more open and less expensive than versatile analytical devices. The quantity of cell phone users overall outperformed 2 billion in 2016 and it addresses more than a fourth of the worldwide population. There have been numerous new articles on the utilization