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Revisiting the Mitochondrial Function and Communication in Neurodegenerative Diseases Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-14 Nitu L. Wankhede, Mayur B. Kale, Mohit D. Umare, Sanket Lokhande, Aman B. Upaganlawar, Pranay Wal, Brijesh G. Taksande, Milind J. Umekar, Prasanna Shama Khandige, Bhupendra Singh, Vandana Sadananda, Seema Ramniwas, Tapan Behl
: Neurodegenerative disorders are distinguished by the progressive loss of anatomically or physiologically relevant neural systems. Atypical mitochondrial morphology and metabolic malfunction are found in many neurodegenerative disorders. Alteration in mitochondrial function can occur as a result of aberrant mitochondrial DNA, altered nuclear enzymes that interact with mitochondria actively or passively
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Deformable Vesicles with Edge Activators for the Transdermal Delivery of Non-Psychoactive Cannabinoids Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-14 Elisa Vettorato, Marisa Fiordelisi, Silvia Ferro, Desirè Zanin, Erica Franceschinis, Giovanni Marzaro, Nicola Realdon
Background: Transdermal delivery of highly lipophilic molecules is challenging due to the strong barrier function of the skin. Vesicles with penetration enhancers are safe and efficient systems that could improve the transdermal delivery of non-psychoactive cannabinoids such as cannabidiol and desoxy-cannabidiol. In the last decades, research interest in desoxy-cannabidiol as a potent drug with anti-nociceptive
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Advances in the Treatment of Kidney Disorders using Mesenchymal Stem Cells Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-14 Shivam Rajput, Rishabha Malviya, Prerna Uniyal
:: Renal disease is a medical condition that poses a potential threat to the life of an individual and is related to substantial morbidity and mortality rates in clinical environments. The aetiology of this condition is influenced by multiple factors, and its incidence tends to increase with progressive aging. Although supportive therapy and kidney transplantation have potential advantages, they also
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Compounds based on Adamantyl-Substituted Amino Acids and Peptides as Potential Antiviral Drugs Acting as Viroporin Inhibitors Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-14 Timur M. Garaev, Tatyana V. Grebennikova, Varvara V. Lebedeva, Varvara V. Avdeeva, Viktor F. Larichev
: The discussion has revolved around the derivatives of amino acids and peptides containing carbocycles and their potential antiviral activity in vitro against influenza A, hepatitis C viruses, and coronavirus. Studies conducted on cell cultures reveal that aminoadamantane amino acid derivatives exhibit the capacity to hinder the replication of viruses containing viroporins. Furthermore, certain compounds
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Network Pharmacology Along with Molecular Docking to Explore the Mechanism of Danshen Injection against Anthracycline-induced Cardiotoxicity and Transcriptome Validation Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-14 Quankai Dai, Yijun Pan, Xiwen Zhu, Mengyao Chen, Lin Xie, Yu Zhu, Guoxing Wan
Introduction:: Although anthracyclines have demonstrated efficacy in cancer therapy, their utilization is constrained by cardiotoxicity. In contrast, Danshen injection (DSI), derived from Salvia miltiorrhiza, has a longstanding tradition of being employed to ameliorate cardiovascular ailments, including anthracycline- induced cardiotoxicity (AIC). Nonetheless, there is a notable dearth of comprehensive
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Specific Targeting of Zinc Transporter LIV-1 with Immunocytokine Containing Anti-LIV-1 VHH and Human IL-2 and Evaluation of its In vitro Antitumor Activity Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-14 Rada Dehghan, Arezoo Beig Parikhani, Reza Ahangari Cohan, Mohammad Ali Shokrgozar, Esmat Mirabzadeh, Soheila Ajdary, Sirous Zeinali, Hajarossadat Ghaderi, Yeganeh Talebkhan, Mahdi Behdani
Background: Interleukin 2 (IL-2) is a vital cytokine in the induction of T and NK cell responses, the proliferation of CD8+ T cells, and the effective treatment of human cancers, such as melanoma and renal cell carcinoma. However, widespread use of this cytokine is limited due to its short half-life, severe toxicity, lack of specific tumor targeting, and activation of Treg cells mediated by high-affinity
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Repurposing of Angiotensin-converting-enzyme Inhibitor on Prevention of Post-surgical Tendon Adhesion Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-12 Hamideh Naimi, Majid Khazaei, Fariba Sharifnia, Sayyed-Hadi Sayyed-Hosseinian
Background:: Formation of adhesion bands is a frequent clinical complication after tendon injury or surgery with limited treatment options. This study investigates the repurposing of Angiotensin-Converting-Enzyme Inhibitor (ACEI) in attenuating post-operative tendon-sheath adhesion bands in an Achilles tendon rat model. Methods:: Structural, mechanical, histological, and biochemical characteristics
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A Snapshot of Selenium-enclosed Nanoparticles for the Management of Cancer Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-11 Rohitas Deshmukh, Rajesh Singh, Sandeep Sharma, Ashwini Kumar Mishra, Ranjit K. Harwansh
: Among the primary causes of mortality in today's world is cancer. Many drugs are employed to give lengthy and severe chemotherapy and radiation therapy, like nitrosoureas (Cisplatin, Oxaliplatin), Antimetabolites (5-fluorouracil, Methotrexate), Topoisomerase inhibitors (Etoposide), Mitotic inhibitors (Doxorubicin); such treatment is associated with significant adverse effects. Antitumor antibiotics
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Remedial Dosing Recommendations for Sirolimus Delayed or Missed Dosages Caused by Poor Medication Compliance in Pediatric Tuberous Sclerosis Complex Patients Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-08 Yang Yang, Lei Jiang, Hai-Rong Zhu, Wen-Xin Sun, Jing-Yu Mao, Jing-Wen Miao, Yi-Chen Wang, Su-Mei He, Dong-Dong Wang, Xiao Chen
Background:: Delayed or missed dosages caused by poor medication compliance significantly affected the treatment of diseases in children. Aims:: The present study aimed to investigate the influence of delayed or missed dosages on sirolimus pharmacokinetics (PK) in pediatric tuberous sclerosis complex (TSC) patients and to recommend remedial dosages for nonadherent patients. Methods:: A published sirolimus
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Machine-learning-guided Directed Evolution for AAV Capsid Engineering Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-06 Xianrong Fu, Hairui Suo, Jiachen Zhang, Dongmei Chen
: Target gene delivery is crucial to gene therapy. Adeno-associated virus (AAV) has emerged as a primary gene therapy vector due to its broad host range, long-term expression, and low pathogenicity. However, AAV vectors have some limitations, such as immunogenicity and insufficient targeting. Designing or modifying capsids is a potential method of improving the efficacy of gene delivery, but hindered
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The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer Therapy Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-05 Sankha Bhattacharya, Paul Beninger
: This review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs) as a promising avenue for cancer therapy within the embryonic landscape of nanotechnology. Nanoparticles, pivotal in cancer treatment, are systematically examined for their diverse physicochemical structures, categorized as organic (lipid-based, protein-based, and polymer-assisted) and inorganic (carbon-based
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Cholesteryl Ester Transfer Protein (CETP) Variations in Relation to Lipid Profiles and Cardiovascular Diseases: An Update Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-01 Siarhei Dabravolski, Nikolay A. Orekhov, Alexandra Melnichenko, Vasily N. Sukhorukov, Mikhail A. Popov, Alexander Orekhov
: Lipid metabolism plays an essential role in the pathogenesis of cardiovascular and metabolic diseases. Cholesteryl ester transfer protein (CETP) is a crucial glycoprotein involved in lipid metabolism by transferring cholesteryl esters (CE) and triglycerides (TG) between plasma lipoproteins. CETP activity results in reduced HDL-C and increased VLDL- and LDL-C concentrations, thus increasing the risk
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Current and Emerging Pharmacological Therapies for Cushing's Disease Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-03-01 Efstathios Divaris, Georgios Kostopoulos, Zoe A. Efstathiadou
: Cushing’s Disease (CD), hypercortisolism due to pituitary ACTH secreting neuroendocrine neoplasm), is associated with increased morbidity and, if untreated, mortality in about half of the affected individuals. Consequently, the timely initiation of effective treatment is mandatory. Neurosurgery is the first line and only potentially curative treatment; however, 30% of patients will have persistent
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Quality by Design Perspective for Designing Foam-based Formulation: Current State of Art Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-29 Mohit Kumar, Devesh Kumar, Shubham Singh, Shruti Chopra, Syed Mahmood, Amit Bhatia
: Foam-based delivery systems contain one or more active ingredients and dispersed solid or liquid components that transform into gaseous form when the valve is actuated. Foams are an attractive and effective delivery approach for medical, cosmetic, and pharmaceutical uses. The foams-based delivery systems are gaining attention due to ease of application as they allow direct application onto the affected
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The Benzene-induced Hepatic Cytochrome P450 2E1 Expression and Activity are Reduced by Quercetin Administration in Mice Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-28 Jambour-Shabestary Amir-Ata, Vardast Mohammad-Reza, Hassan Malekinejad
Background: Benzene as an environmental and industrial agent induces adverse effects that are mainly metabolism-dependent. Objectives: Effects of Quercetin (QCN) on Benzene (BNZ)-induced changes in the hepatic Cytochrome P450 2E1 expression and activity were investigated. Methods: Thirty-six adult male mice were divided into 6 groups (n = 6) and nominated as control, BNZ (exposed to BNZ: 30 ppm), QCN
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Efficacy and Safety Analysis of Botox Application and Iatrogenic Botulism: Panacea or Peril? Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-27 Ozgur Karcioglu, Canan Akman, Ilknur Atnis
: Clostridium botulinum toxin-A (BoNT-A) creates temporary paralysis in the muscles by acting on the muscle-nerve junction. It is injected into the mimic muscles when a decrease in the movements of the mimic muscles is desired. Despite many favorable applications, the use of BoNT-A is not without drawbacks. Although there is no expected serious side effect on health in BoNT-A treatments, various problems
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The Potential Mechanism of Liujunzi Decoction in the Treatment of Breast Cancer Based on Network Pharmacology and Molecular Docking Technology Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-26 Mei Sun, Feng Lv, Chunmeng Qin, Dan Du, Wenjun Li, Songqing Liu
Background: Liujunzi Decoction (LJZD) is a potential clinical treatment for Breast Cancer (BC), but the active ingredients and mechanisms underlying its effectiveness remain unclear. Objective: The study aimed to investigate the target gene of LJZD compatibility and the possible mechanism of action in the treatment of breast cancer by using network pharmacology and molecular docking. Methods: Based
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Preparation Optimization and Immunological Activity Studies of Portulaca oleracea L. Polysaccharides Liposomes Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-22 Yan Li, Guiyan Jia, Tao Li, Xiechen Zhou, Hui Zhao, Junyang Cao, Zijian Guan, Rui Zhao
Aims:: This study combines traditional Chinese medicine polysaccharides with nanomaterials to enhance drug bioavailability and immunological activity. Background:: The study of polysaccharide preparation, structure identification, pharmacological activity, and mechanism of action is deepening, but the research combined with the new drug delivery system is relatively weak, so the application of polysaccharides
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Pharmacological Considerations during Percutaneous Treatment of HeartFailure Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-20 Jose Antonio Sorolla-Romero, Javier Navarrete-Navarro, Julia Martinez-Sole, Hector M. Garcia Garcia, Jose Luis Diez-Gil, Luis Martinez-Dolz, Jorge Sanz-Sanchez
Heart Failure (HF) remains a global health challenge, marked by its widespread prevalence and substantial resource utilization. Although the prognosis has improved in recent decades due to the treatments implemented, it continues to generate high morbidity and mortality in the medium to long term. Interventional cardiology has emerged as a crucial player in HF management, offering a diverse array of
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Safety Profile of Paxlovid in the Treatment of COVID-19 Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-20 Bing Lv, Xin Gao, Guoqiang Zeng, Hui Guo, Faping Li
Background: With the urgent and widespread application of Paxlovid, a novel antiviral drug for Coronavirus Disease 2019 (COVID-19) in clinical practice, concerns regarding its actual efficacy and safety have emerged. In order to provide more evidence to support its clinical application, we sought to perform a descriptive analysis of cases who experienced at least one Paxlovid-related adverse event
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The Potential of Natural Products in the Management of Cardiovascular Disease Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-20 Harshita Singhai, Sunny Rathee, Sanjay K. Jain, Umesh Kumar Patil
Cardiovascular Disease (CVD) is one of the most prevalent diseases in the world, comprising a variety of disorders such as hypertension, heart attacks, Peripheral Vascular Disease (PVD), dyslipidemias, strokes, coronary heart disease, and cardiomyopathies. The World Health Organization (WHO) predicts that 22.2 million people will die from CVD in 2030. Conventional treatments for CVDs are often quite
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Relationship between Compound α-Ketoacid and Microinflammation in Patients with Chronic Kidney Disease Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-19 Zaobin Chen, Yongda Lin, Jiali Wang, Kaijin Yao, Yina Xie, Xiutian Chen, Tianbiao Zhou
Chronic kidney disease (CKD) refers to the presence of structural or functional abnormalities in the kidneys that affect health, lasting for more than 3 months. CKD is not only the direct cause of global incidence rate and mortality, but also an important risk factor for cardiovascular disease. Persistent microinflammatory state has been recognized as an important component of CKD, which can lead to
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Network Pharmacology Analysis on the Mechanism of Xihuangwan in Treating Rectal Cancer and Radiation Enteritis Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-19 Minghe Lv, Rong Ding, Peizhen Ma, Yue Feng, Su Zeng, Yang Zhang, Wenhao Shen, Wenhui Guan, Xiangyu E., Hongwei Zeng, Jingping Yu
Background: Recent studies have shown that XihuangWan (XHW) is a kind of Chinese medicine with significant anti-tumor and anti-inflammatory activities. However, its mechanism for preventing and treating radiation proctitis in rectal cancer patients during radiotherapy remains unclear. Methods: This study employed the network pharmacology to establish a “drug-active ingredient-target genedisease” network
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A New Cell Model Overexpressing sTGFBR3 for Studying Alzheimer's Disease In vitro Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-15 Jiangxia Chen, Lijun Zhou, Qingchun Zhao, Zhentong Qi
Background: Recent studies have suggested that abnormal microglial hyperactivation has an important role in the progression of Alzheimer's disease (AD). sTGFBR3 (a shed extracellular domain of the transforming growth factor type III receptor) is a newly identified target of microglia polarization dysregulation, whose overexpression can cause abnormal accumulation of transforming growth factor β1 (TGF-β1)
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Viral MicroRNAs in Herpes Simplex Virus 1 Pathobiology Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-12 Raza Ali Naqvi, Araceli Valverde, Tejabhiram Yadavalli, Fatima Ismail Bobat, Kristelle J. Capistrano, Deepak Shukla, Afsar R. Naqvi
Simplexvirus humanalpha1 (Herpes simplex virus type 1 [HSV-1]) infects millions of people globally, manifesting as vesiculo-ulcerative lesions of the oral or genital mucosa. After primary infection, the virus establishes latency in the peripheral neurons and reactivates sporadically in response to various environmental and genetic factors. A unique feature of herpesviruses is their ability to encode
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Roles of AFAP1-AS1 in Gynecology and Urogenital System Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-12 Xinyan Qiu, Yulin Huang, Lin Jin, Canying Yang, Jiwei Wang
Background: Human disease onset and progression are strongly associated with aberrant long noncoding RNA (lncRNA) expression, highlighting the functional regulatory role of lncRNA. Actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1), a member of lncRNAs, is located on the antisense strand of Actin filament-associated protein 1 (AFAP1). Methods: We conducted a comprehensive review of AFAP1-AS1's
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Silencing FUT4 Inhibits the Progression of Osteosarcoma through Activation of FOXO1 Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-12 Yang Yang, Xiaodi Yan, YueYuan Chen, Jiajia Liu, Jianhua Xue, Xiaoming Sheng, Jun Qin, Qiang Xue, Xianchen Liu
Background:: It has been reported that inhibition of Fucosyltransferase4 (FUT4) to activate Forkhead box O1 (FOXO1) can lead to apoptosis of cancer cells, however, the mechanism in osteosarcoma is still unclear. Objective:: To explore the biological significance of the connection between FUT4 and FOXO1 in osteosarcoma growth. Methods:: In vitro tests were conducted using the human osteoblast cell line
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Underlying Mechanism of Traditional Herbal Formula Chuang-Ling-Ye in the Treatment of Diabetic Foot Ulcer through Network Pharmacology and Molecular Docking Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-12 Jinyuan Geng, Guowei Zhou, Song Guo, Chaoqun Ma, Jiangfeng Ma
Background:: Chuang-Ling-Ye (CLY) has been clinically proven to be an effective Chinese medicine for the treatment of diabetic foot ulcers (DFU). Objectives:: This study aimed to investigate the possible mechanism of CLY in relation to DFU using network pharmacology and molecular docking. Materials and Methods:: Firstly, relevant targets of CLY against DFU were obtained from TCMSP, Swiss Target Prediction
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2,5-Diketopiperazines (DKPs): Promising Scaffolds for Anticancer Agents Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-09 Shaimaa S. Goher, Wessam S. Abdrabo, Giri Babu Veerakanellore, Bahaa Elgendy
2,5-Diketopiperazine (2,5-DKP) derivatives represent a family of secondary metabolites widely produced by bacteria, fungi, plants, animals, and marine organisms. Many natural products with DKP scaffolds exhibited various pharmacological activities such as antiviral, antifungal, antibacterial, and antitumor. 2,5-DKPs are recognized as privileged structures in medicinal chemistry, and compounds that
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Anticoagulation in Patients with Atrial High-rate Episodes Detected by Cardiac Implantable Electronic Devices Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-09 Michael Spartalis, Christos Kontogiannis, Eleftherios Spartalis, Dimitrios C. Iliopoulos, Gerasimos Siasos
Atrial high-rate episodes (AHRE) are atrial tachyarrhythmias that are identified by the use of continuous rhythm monitoring devices such as pacemakers, defibrillators, or implantable cardiac monitors. Nevertheless, the therapeutic implications of these rhythm disturbances remain uncertain. The presence of AHRE is associated with an increased risk of stroke as compared to patients who do not exhibit
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Effects of High Efficacy Multiple Sclerosis Disease Modifying Drugs on the Immune Synapse: A Systematic Review Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-09 Spyros N. Deftereos, George D. Vavougios, Christos Bakirtzis, George Hadjigeorgiou, Nikolaos Grigoriadis
Background: Co-signaling and adhesion molecules are important elements for creating immune synapses between T lymphocytes and antigen-presenting cells; they positively or negatively regulate the interaction between a T cell receptor with its cognate antigen, presented by the major histocompatibility complex. Objectives: We conducted a systematic review on the effects of High Efficacy Disease Modifying
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LSTM-SAGDTA: Predicting Drug-target Binding Affinity with an Attention Graph Neural Network and LSTM Approach Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-07 Wenjing Qiu, Qianle Liang, Liyi Yu, Xuan Xiao, Wangren Qiu, Weizhong Lin
Introduction: Drug development is a challenging and costly process, yet it plays a crucial role in improving healthcare outcomes. Drug development requires extensive research and testing to meet the demands for economic efficiency, cures, and pain relief. Methods: Drug development is a vital research area that necessitates innovation and collaboration to achieve significant breakthroughs. Computer-aided
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Traditional Uses, Phytochemistry, and Pharmacological Activities of Coleus amboinicus: A Comprehensive Review Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-06 Karthika Paul, Benachakal Honnegowda Jaswanth Gowda, Umme Hani, Ravandur Shivanna Chandan, Sourav Mohanto, Mohammed Gulzar Ahmed, Sumel Ashique, Prashant Kesharwani
Coleus amboinicus Benth., also known as Plectranthus amboinicus (Lour.) Spreng., is a perennial plant from the Lamiaceae family commonly found in tropical and warm regions of Africa, Asia, and Australia. Folk medicine commonly employs this remedy to address various ailments, including but not limited to asthma, headaches, skin disorders, coughs, constipation, colds, and fevers. Several phytoconstituents
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A Strategy Based on Bioinformatics and Machine Learning Algorithms Reveals Potential Mechanisms of Shelian Capsule Against Hepatocellular Carcinoma Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-04 Xianqiang Zhou, Fang Tan, Suxian Zhang, An'an Wang, Tiansong Zhang
Background: Hepatocellular carcinoma (HCC) is a prevalent and life-threatening form of cancer, with Shelian Capsule (SLC), a traditional Chinese medicine (TCM) formulation, being recommended for clinical treatment. However, the mechanisms underlying its efficacy remain elusive. This study sought to uncover the potential mechanisms of SLC in HCC treatment using bioinformatics methods. Methods: Bioactive
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Network Pharmacology and In vitro Experimental Verification to Explore the Mechanism of Chaiqin Qingning Capsule in the Treatment of Pain Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-04 Hongjin Gao, Zhengwei Chen, Buliduhong Halihaman, Lianzhan Huang, Zhen Wang, Xuansheng Ding
Background: Chaiqin Qingning capsule (CQQNC) has been used to relieve pain in practice. However, the active components, pain targets, and molecular mechanisms for pain control are unclear. Objective: To explore the active components and potential mechanisms of the analgesic effect of CQQNC through network pharmacology and in vitro experiments. Methods: The main active components and the corresponding
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Unveiling the Potential of Serum MiR-483-5p: A Promising Diagnostic and Prognostic Biomarker in OLP and OSCC Patients by In silico Analysis of Differential Gene Expression Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-04 Pouria Soltaninezhad, Fatemeh Arab, Nooshin Mohtasham, Mohammadhossein FakherBaheri, Nima Nikbin Kavishahi, Seyed Hamid Aghaee-Bakhtiari, Reza Zare-Mahmoodabadi, Atessa Pakfetrat, Kiarash Izadi Taban, Farnaz Mohajertehran
Background:: Oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP) are two separate conditions affecting the mouth and result in varying clinical outcomes and levels of malignancy. Achieving early diagnosis and effective therapy planning requires the identification of reliable diagnostic biomarkers for these disorders. MicroRNAs (miRNAs) have recently received attention as powerful biomarkers
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Vitamin D as a Modulator of Neuroinflammation: Implications for Brain Health Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-02 Sebastián García Menéndez, Walter Manucha
: Neuroinflammation represents a critical immune response within the brain, playing a pivotal role in defense against injury and infection. However, when this response becomes chronic, it can contribute to the development of various neurodegenerative and psychiatric disorders. This bibliographic review delves into the role of vitamin D in modulating neuroinflammation and its implications for brain
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N-Acylhydrazone Pharmacophore's Analgesic and Anti-inflammatory Profile: Recent Advancements during the Past Ten Years Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-02 Asmaa E. Kassab
: Due to its important biological and pharmacological properties, in the field of medicinal chemistry and drug discovery, the N-acylhydrazone motif has shown to be extremely adaptable and promising. This scaffold has become a crucial component in the synthesis of numerous bioactive agents. N-Acylhydrazones are also interesting biological and synthetic tools due to their easy and straightforward synthesis
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Interplay between LncRNA/miRNA and TGF-β Signaling in the Tumorigenesis of Gynecological Cancer Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-02 Pegah Safavi, Kimia Behrouz Moghadam, Zahra Haghighi, Gordon A. Ferns, Farzad Rahmani
: Gynecologic cancers are among the most common malignancies with aggressive features and poor prognosis. Tumorigenesis in gynecologic cancers is a complicated process that is influenced by multiple factors, including genetic mutations that activate various oncogenic signaling pathways, including the TGF-β pathway. Aberrant activation of TGF-β signaling is correlated with tumor recurrence and metastasis
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Exploring the Effect of Xiao-Chai-Hu Decoction on Treating Psoriasis Based on Network Pharmacology and Experiment Validation Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-02-01 Ke He, Ziyang Wang, Meng Liu, Wenqian Du, Tingyi Yin, Ruimin Bai, Qiqi Duan, Yuqian Wang, Hao Lei, Yan Zheng
Background: Psoriasis is a chronic, inflammatory and recurrent skin disease. Xiao-Chai-Hu Decoction (XCHD) has shown good effects against some inflammatory diseases and cancers. However, the pharmacological effect and mechanisms of XCHD on psoriasis are not yet clear. Objective: To uncover the effect and mechanisms of XCHD on psoriasis by integrating network pharmacology, molecular docking, and in
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Recent Updates on the Therapeutics Benefits, Clinical Trials, and Novel Delivery Systems of Chlorogenic Acid for the Management of Diseases with a Special Emphasis on Ulcerative Colitis Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-31 Ranjit K. Harwansh, Hemant Bhati, Rohitas Deshmukh
Ulcerative colitis (UC) is a multifactorial disorder of the large intestine, especially the colon, and has become a challenge globally. Allopathic medicines are primarily available for the treatment and prevention of UC. However, their uses are limited due to several side effects. Hence, an alternative therapy is of utmost importance in this regard. Herbal medicines are considered safe and effective
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Efficacy of Methylphenidate for Internet Gaming Disorder and Internet Addiction in Patients with Attention-Deficit/Hyperactivity Disorder Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-31 Andrea Salvati, Gianluca Sesso, Francesca Lenzi, Gabriele Masi, Stefano Berloffa
Background: Internet Gaming Disorder (IGD) and Internet Addiction (IA) are related clinical conditions often comorbid with Attention-Deficit/Hyperactivity Disorder (ADHD). Objective: We evaluated the efficacy of MPH for IGD/IA symptoms in ADHD patients. Methods: We enrolled 38 drug-naive patients diagnosed with ADHD (Attention-Deficit/Hyperactivity Disorder) and IGD/IA. At baseline, all patients underwent
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Human Data on Pharmacokinetic Interactions of Cannabinoids: A Narrative Review Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-29 Cecilia Maldonado, Raquel Peyraube, Pietro Fagiolino, Florencia Oricchio, Leticia Cuñetti, Marta Vázquez
: Concomitant use of cannabinoids with other drugs may result in pharmacokinetic drug-drug interactions, mainly due to the mechanism involving Phase I and Phase II enzymes and/or efflux transporters. Cannabinoids are not only substrates but also inhibitors or inducers of some of these enzymes and/or transporters. This narrative review aims to provide the available information reported in the literature
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Statin Therapy and Lipid Indices in Chronic Kidney Disease: A Systematic Review and Meta-analysis of Randomized Control Trials Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-26 Jafar Karami, Bahman Razi, Danyal Imani, Saeed Aslani, Mahdi Pakjoo, Mahdieh Fasihi, Keyhan Mohammadi, Amirhossein Sahebkar
Background: Several studies have demonstrated the improvement in serum lipoproteins by statins in patients with Chronic Kidney Diseases (CKDs), including End-Stage Renal Disease (ESRD). However, the results of these studies are inconclusive. Aims: We aimed to systematically investigate the effect of statins on lipid profiles of patients with CKD by performing a meta-analysis of Randomized Controlled
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Organogels: “GelVolution” in Topical Drug Delivery - Present and Beyond Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-25 Ajinkya Nitin Nikam, Amrita Roy, Ruchira Raychaudhuri, Prerana D. Navti, Soji Soman, Sanjay Kulkarni, Krishnaraj Somayaji Shirur, Abhijeet Pandey, Srinivas Mutalik
Topical drug delivery holds immense significance in dermatological treatments due to its non-invasive nature and direct application to the target site. Organogels, a promising class of topical drug delivery systems, have acquired substantial attention for enhancing drug delivery efficiency. This review article aims to explore the advantages of organogels, including enhanced drug solubility, controlled
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Free Radicals, Mitochondrial Dysfunction and Sepsis-induced Organ Dysfunction: A Mechanistic Insight Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-21 Sanni Kumar, Vijay Kumar Srivastava, Sanket Kaushik, Juhi Saxena, Anupam Jyoti
: Sepsis is a complex clinical condition and a leading cause of death worldwide. During Sepsis, there is a derailment in the host response to infection, which can progress to severe sepsis and multiple organ dysfunction or failure, which leads to death. Free radicals, including reactive oxygen species (ROS) generated predominantly in mitochondria, are one of the key players in impairing normal organ
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The Significance and Importance of dPCR, qPCR, and SYBR Green PCR Kit in the Detection of Numerous Diseases Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-21 Mohamad Hesam Shahrajabian, Wenli Sun
: Digital PCR (dPCR) is the latest technique that has become commercially accessible for various types of research. This method uses Taq polymerase in a standard polymerase chain reaction (PCR) to amplify a target DNA fragment from a complex sample, like quantitative PCR (qPCR) and droplet digital PCR (dd- PCR). ddPCR may facilitate microRNA (miRNA) measurement, particularly in liquid biopsy, because
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Artesunate Inhibits the Growth of Insulinoma Cells via SLC7A11/GPX4-mediated Ferroptosis Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-21 Fengping Chen, Jiexia Lu, Biaolin Zheng, Nan Yi, Chunxiao Xie, Feiran Chen, Dafu Wei, Haixing Jiang, Shanyu Qin
Background: Artesunate (ART) has been recognized to induce ferroptosis in various tumor phenotypes, including neuroendocrine tumors. We aimed to investigate the effects of ART on insulinoma and the underlying mechanisms by focusing on the process of ferroptosis. Methods: The CCK8 and colony formation assays were conducted to assess the effectiveness of ART. Lipid peroxidation, glutathione, and intracellular
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GLP-1/GLP-1RAs: New Options for the Drug Treatment of NAFLD Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-18 Haoran Jiang, Linquan Zang
: Non-alcoholic fatty liver disease (NAFLD) has recently emerged as a global public health concern. Currently, the cornerstone of NAFLD treatment is lifestyle modification and, if necessary, weight loss. However, compliance is a challenge, and this approach alone may not be sufficient to halt and treat the more serious disease development, so medication is urgently needed. Nevertheless, no medicines
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Neuro-protective Effect of Acetyl-11-keto-β-boswellic Acid in a Rat Model of Scopolamine-induced Cholinergic Dysfunction Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-18 Amir Hossein Assaran, Mahmoud Hosseini, Matin Shirazinia, Mohammad Hosein Eshaghi Ghalibaf, Farimah Beheshti, Leila Mobasheri, Farshad Mirzavi, Arezoo Rajabian
Background:: Acetyl-11-keto-β-boswellic acid (AKBA) is a major component of the oleo-gum resin of B. serrata with multiple pharmacological activities. The objective of this study was to explore the underlying mechanisms of neuroprotective potential of AKBA against scopolamine-mediated cholinergic dysfunction and memory deficits in rats. Methods:: The rats received AKBA (2.5, 5, and 10 mg/kg, oral)
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Capsicum annuum Oleoresin Nanoemulgel - Design Characterization and In vitro Investigation of Anticancer and Antimicrobial Activities Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-18 Ahmad M. Eid, Hiba Natsheh, Linda Issa, Majdulin Zoabi, Monia Amer, Effat Mahamid, Ahmed Mousa
Background:: The use of naturally occurring bioactive materials is getting great attention owing to their safety and environmental properties. Oily compounds, known as oleoresins, are expected to provide an important source for the natural products industry aiming to develop novel treatments for skin conditions. In this work, Capsicum annuum oleoresin nanoemulgel formulations have been prepared and
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Deciphering Multi-target Pharmacological Mechanism of Cucurbita pepo Seeds against Kidney Stones: Network Pharmacology and Molecular Docking Approach Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-10 Aqsa Shahzadi, Usman Ali Ashfaq, Mohsin Khurshid, Muhammad Atif Nisar, Asad Syed, Ali H. Bahkali
Background: Urolithiasis is a prevalent condition with significant morbidity and economic implications. The economic burden associated with urolithiasis primarily stems from medical expenses. Previous literature suggests that herbal plants, including Cucurbita pepo, have lithotriptic capabilities. C. pepo is an annual, herbaceous, widely grown, and monoecious vegetative plant known for its antioxidants
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Novel Arena of Nanocosmetics: Applications and their Remarkable Contribution in the Management of Dermal Disorders, Topical Delivery, Future Trends and Challenges Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-10 Ashima Ahuja, Meenakshi Bajpai
Nanocosmetics have attracted a considerable audience towards natural care due to their low cost, target-specific delivery, and reduced toxicity compared to chemical-based cosmetics. Nanofomulations, including nanoemulsions, nanotubes, and polymeric carriers, have become next-generation products explored for the multifaced applications of nanotechnology in skin care. The rise in the cosmetic industry
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Carbon Nanotubes for Targeted Therapy: Safety, Efficacy, Feasibility and Regulatory Aspects Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-05 Babita Gupta, Pramod Kumar Sharma, Rishabha Malviya
It is crucial that novel and efficient drug delivery techniques be created in order to improve the pharmacological profiles of a wide variety of classes of medicinal compounds. Carbon nanotubes (CNTs) have recently come to the forefront as an innovative and very effective technique for transporting and translocating medicinal compounds. CNTs were suggested and aggressively researched as multifunctional
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Role of Amphotericin B in the Treatment of Mucormycosis Curr. Pharm. Des. (IF 3.1) Pub Date : 2024-01-04 Alisha Sachdeva, Monika Targhotra, Meenakshi Kanwar Chauhan, Monica Chopra
Background: Regardless of the most recent inclusion of mold-active agents (isavuconazole and posaconazole) to antifungal agents against mucormycosis, in conjunction with amphotericin B (AMB) items, numerous uncertainties still exist regarding the treatment of this rare infection. The order Mucorales contains a variety of fungi that cause the serious but uncommon fungal illness known as mucormycosis
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A Mechanistic Review on Therapeutic Potential of Medicinal Plants and their Pharmacologically Active Molecules for Targeting Metabolic Syndrome Curr. Pharm. Des. (IF 3.1) Pub Date : 2023-12-28 Vinod Kumar Gauttam, Kavita Munjal, Hitesh Chopra, Aftab Ahmad, Mahesh Kumar Rana, Mohammad Amjad Kamal
Metabolic syndrome (MetS) therapy with phytochemicals is an emerging field of study with therapeutic potential. Obesity, insulin resistance, high blood pressure, and abnormal lipid profiles are all components of metabolic syndrome, which is a major public health concern across the world. New research highlights the promise of phytochemicals found in foods, including fruits, vegetables, herbs, and spices
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Nanocomposite Hydrogels-A Promising Approach towards Enhanced Bioavailability and Controlled Drug Delivery Curr. Pharm. Des. (IF 3.1) Pub Date : 2023-12-28 Nariman Shahid, Alia Erum, Sana Hanif, Nadia Shamshad Malik, Ume Ruqia Tulain, Muhammad Ali Syed
Nanotechnology has emerged as the eminent focus of today’s research to overcome challenges related to conventional drug delivery systems. A wide spectrum of novel delivery systems has been investigated to improve the therapeutic outcomes of drugs. The polymer-based nanocomposite hydrogels (NCHs) that have evolved as efficient carriers for controlled drug delivery are of particular interest in this
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Microbubbles: Revolutionizing Biomedical Applications with Tailored Therapeutic Precision Curr. Pharm. Des. (IF 3.1) Pub Date : 2023-12-28 Mohit Kumar, Devesh Kumar, Shruti Chopra, Syed Mahmood, Amit Bhatia
Background: Over the past ten years, tremendous progress has been made in microbubble-based research for a variety of biological applications. Microbubbles emerged as a compelling and dynamic tool in modern drug delivery systems. They are employed to deliver drugs or genes to targeted regions of interest, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive
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Differential Signaling Pathways in Medulloblastoma: Nano-biomedicine Targeting Non-coding Epigenetics to Improve Current and Future Therapeutics Curr. Pharm. Des. (IF 3.1) Pub Date : 2023-12-27 Daniil Sokolov, Neha Sharda, Aindrila Banerjee, Kseniia Denisenko, Emad B. Basalious, Hem Shukla, Jaylyn Waddell, Nadia M. Hamdy, Aditi Banerjee
Background: Medulloblastomas (MDB) are malignant, aggressive brain tumors that primarily affect children. The survival rate for children under 14 is approximately 72%, while for ages 15 to 39, it is around 78%. A growing body of evidence suggests that dysregulation of signaling mechanisms and noncoding RNA epigenetics play a pivotal role in this disease. Methodology: This study conducted an electronic
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Interplay of G-proteins and Serotonin in the Neuroimmunoinflammatory Model of Chronic Stress and Depression: A Narrative Review Curr. Pharm. Des. (IF 3.1) Pub Date : 2023-12-27 Evgenii Gusev, Alexey Sarapultsev
Introduction: This narrative review addresses the clinical challenges in stress-related disorders such as depression, focusing on the interplay between neuron-specific and pro-inflammatory mechanisms at the cellular, cerebral, and systemic levels. Objective: We aim to elucidate the molecular mechanisms linking chronic psychological stress with low-grade neuroinflammation in key brain regions, particularly