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Volatile Oil of Magnolia biondii Pamp. for Transnasal Administration: Its Preparation, Characterization, And Mechanism of Action in the Treatment of Allergic Rhinitis Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-03-05 Qiuting Guo, Xuan Wang, Yao Wang, Peijie Zhou, Xiaofei Zhang
Background:: Allergic Rhinitis (AR) is a common chronic nasal condition usually caused by allergens. The immune system overreacts when the body is exposed to allergens, releasing a lot of tissue chemicals that cause congestion, more secretions, and an inflammatory reaction in the nasal mucosa. Method:: In clinical practice, it remains a significant public health issue. Modern pharmacological studies
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Review of Phytosomes and Ethosomes: Groundbreaking Approaches for Delivering the Phytochemical Components of Plants Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-03-01 Asha Raghav, Meenakshi Attri, Hema Chaudhary
: Phytoconstituents have been widely used since ancient times to form a complex with phospholipids due to their various therapeutic actions. Despite having strong pharmacodynamic efficiency, numerous phytoconstituents have shown lower in vivo bioavailability and few adverse effects. Phytochemicals soluble in water exhibit poor absorption, leading to a limited therapeutic impact. Phytosome nanotechnology
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An Enzyme-responsive Porphyrin Metal-organic Framework Nanosystem for Targeted and Enhanced Synergistic Cancer Photo-chemo Therapy Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-03-01 Mengqi Yi, Yangxin Lin, Yuyang Li, Bei Xiong, Yunhan Huang, Wei Guo, Bo Lu
Background: The clinical efficiency of photodynamic therapy (PDT) in combination with chemotherapy has proven to be a promising strategy for tumor treatment, yet is restricted by the high glutathione (GSH) concentration at the tumor site and nonspecific drug targeting. Objective: The goal of the current research was to create a biocompatible GSH-depleting and tumor- targeting nanoparticle (denoted
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Targeted Bacterial Keratitis Treatment with Polyethylene Glycol-Dithiothreitol- Boric Acid Hydrogel and Gatifloxacin Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-03-01 Xiao Shen, Chunlian Huang, Jian-hai Bai, Jing Wen
Objective:: To prolong the ocular residence time of gatifloxacin and enhance its efficacy against bacterial keratitis, this study developed a velocity-controlled polyethylene glycol-dithiothreitol- boric acid (PDB) hydrogel loaded with gatifloxacin. Materials and Methods:: First, the basic properties of the synthesized PDB hydrogel and the gatifloxacin- loaded PDB hydrogel were assessed. Secondly,
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Current Progress and Emerging Role of Essential Oils in Drug Delivery Therapeutics Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-02-27 Rokeya Sultana, Sourav Mohanto, Adrija Bhunia, Aritra Biswas, Mohammad Shabib Akhtar, Vijay Mishra, Dimple Modi, Alaa Aa Aljabali, Murtaza Tambuwala, Md. Faiyazuddin
: The utilization of novel drug delivery systems loaded with essential oils has gained significant attention as a promising approach for biomedical applications in recent years. Plants possess essential oils that exhibit various medicinal properties, i.e., anti-oxidant, anti-microbial, anti- inflammatory, anti-cancer, immunomodulatory, etc., due to the presence of various phytoconstituents, including
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Transfersomes: Recent Advances, Mechanisms, Exhaustive Applications, Clinical Trials, and Patents Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-02-22 Deeksha Manchanda, Manish Makhija, Parijat Pandey, Manu Sharma
: A feasible nano transdermal delivery system generally intends to have specific ideal and distinct characteristics primarily for safety, clinical efficacy, and boosted therapeutic index. The delivery of drugs, particularly macromolecules, across the skin is one of the most strenuous obstacles in front of pharmaceutical scientists. Technology advancement has provided some opportunities to overcome
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Designing, Optimising, and Assessing a Novel Emulgel Containing Minoxidil for Controlled Drug Release, Incorporating Marine-based Polymers Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-02-16 Flowerlet Mathew, A. Mary Saral
Objective:: This study aimed to develop an emulgel containing minoxidil as a drug for hair growth promotion in diseases, such as androgenetic alopecia, using gelling agents, such as chitosan and fucoidan. Methods:: In this study, gelling agents were selected for the emulgel formulation. By various evaluation tests and through optimization, the chitosan-fucoidan combination was selected as the gelling
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Mannose: A Promising Player in Clinical and Biomedical Applications Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-02-04 Sijing Chen, Kana Wang, Qiao Wang
: Mannose, an isomer of glucose, exhibits a distinct molecular structure with the same formula but a different atom arrangement, contributing to its specific biological functions. Widely distributed in body fluids and tissues, particularly in the nervous system, skin, testes, and retinas, mannose plays a crucial role as a direct precursor for glycoprotein synthesis. Glycoproteins, essential for immune
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Preparation, Characterization, and Evaluation of Mesoporous Silica Nanoparticles in Enhancing Oral Bioavailability of Poorly Water-Soluble Drugs Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-02-04 Hong Zhang, Fanjiao Zuo, Boyao Wang, Xilong Qiu
Background: Breviscapine (BVP) is one of the extracts of several flavonoids of Erigeron breviscapus, which has been widely used in the treatment of cerebral infarction and its sequelae, cerebral thrombus, coronary heart disease, and angina pectoris. But BVP has poor solubility. Objective: The objective of the study is to develop mesoporous silica nanoparticles (MSNs) that can be loaded with a drug
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Intelligent Drug Delivery: Pioneering Stimuli-Responsive Systems to Revolutionize Disease Management- An In-depth Exploration Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-02-04 Badarinadh Kallepalli, Unnati Garg, Neha Jain, Rohan Nagpal, Sakshi Malhotra, Triveni Tiwari, Shreya Kaul, Upendra Nagaich
: In recent years, there has been an escalating interest in stimuli-responsive drug delivery systems (SRDDS) due to their ability to revolutionize the delivery of therapeutics. SRDDSs offer a multitude of benefits in comparison to conventional drug delivery systems (DDS), including spatiotemporal control of drug release, targeted delivery, and improved therapeutic efficacy. The development of various
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Novel Biomaterials Based Strategies for Neurodegeneration: Recent Advancements and Future Prospects Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-02-04 Dilpreet Singh, Sanjay Nagdev
: Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, pose significant challenges for effective treatment due to the complex nature of the central nervous system and the limited delivery of therapeutic agents to the brain. Biomaterial-based drug delivery systems offer promising strategies to overcome these challenges and improve therapeutic outcomes
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Effective Strategies in Designing Chitosan-hyaluronic Acid Nanocarriers: From Synthesis to Drug Delivery Towards Chemotherapy Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-02-04 Long-Quy Hong, Thao N.T Ho, Son T. Cu, Lien Tuyet Ngan, Tran Ngoc Quyen, Tien T. Dang
: The biomedical field faces an ongoing challenge in developing more effective anti-cancer medication due to the significant burden that cancer poses on human health. Extensive research has been conducted on the utilization of natural polysaccharides in nanomedicine owing to their properties of biocompatibility, biodegradability, non-immunogenicity, and non-toxicity. These characteristics make them
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Emerging Phytochemical Formulations for Management of Rheumatoid Arthritis: A Review Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-02-01 Prachi Pimple, Jenny Shah, Prabha Singh
: Rheumatoid arthritis (RA) is a T-cell-mediated chronic inflammatory disorder affecting 0.5-1% of the global population. The disease with unknown etiology causes slow destruction of joints, advancing to significant deterioration of an individual’s quality of life. The present treatment strategy comprises the use of disease-modifying anti-rheumatic drugs (DMARDs) coupled with or without nonsteroidal
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Influence of Nano-Particulate Impurities and β-glucans on the Stability of Protein-Based Formulations Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-02-01 Soumya Ranjan Satapathy, Rudra Narayan Sahoo, Amit Kumar Nayak
: Pharmaceutical grade sugars manufactured under Current Good Manufacturing Practice (cGMP) and complied with International Pharmaceutical Excipients Council (IPEC) quality standards, also contain a significant amount of nano-particulate impurities (NPIs). This review will focus on the origin of NPIs, the mechanism of their interference with Dynamic light scattering (DLS) and endotoxin tests, filtration
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Smart Ultrasound-responsive Polymers for Drug Delivery: An Overview on Advanced Stimuli-sensitive Materials and Techniques Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-29 Mostafa Yazdan, Seyed Morteza Naghib
: In recent years, a notable advancement has occurred in the domain of drug delivery systems via the integration of intelligent polymers that respond to ultrasound. The implementation of this groundbreaking methodology has significantly revolutionised the controlled and precise delivery of therapeutic interventions. An in-depth investigation is conducted into the most recent developments in ultrasonic
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Fiber Technology in Drug Delivery and Pharmaceuticals Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-26 Shivang Dhoundiyal, Aditya Sharma, Md. Aftab Alam
: The field of fiber technology is a dynamic and innovative domain that offers novel solutions for controlled and targeted therapeutic interventions. This abstract provides an overview of key aspects within this field, encompassing a range of techniques, applications, commercial developments, intellectual property, and regulatory considerations. The foundational introduction establishes the significance
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A Comprehensive Review on Polyphenols Based Nanovesicular System for Topical Delivery Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-26 Anshu Singh, Zeeshan Fatima, Dipti Srivastava
Background: Polyphenols are naturally occurring compounds having more than one hydroxy functional group. They are ubiquitous secondary plant metabolites possessing a wide range of pharmacological activity. Brightly colored fruits and vegetables are the natural source of polyphenols. Majorly, they possess antioxidant, anti-inflammatory and antimicrobial properties which make them suitable candidates
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Recent Developments in Tyrosine Kinase Inhibitor-based Nanotherapeutics for EGFR-resistant Non-small Cell Lung Cancer Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-25 Eknath Kole, Krishna Jadhav, Raghuraj Singh, Shilpa Mandpe, Ashwin Abhang, Rahul K. Verma, Jitendra Naik
: The advent of drug resistance in response to epidermal growth factor receptor (EGFR)- tyrosine kinase inhibitor (TKI) targeted therapy represents a serious challenge in the management of non-small cell lung cancer (NSCLC). These acquired resistance mutations, attributed to several advanced EGFR mutations and, necessitated the development of new-generation TKIs. Nanomedicine approaches provide a plausible
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Recent Advancement in Inhaled Nano-drug Delivery for Pulmonary, Nasal, and Nose-to-brain Diseases Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-25 Qiuxia Fu, Yangjie Liu, Cao Peng, Tobias Achu Muluh, Umer Anayyat, Liu Liang
: Pulmonary, nasal, and nose-to-brain diseases involve clinical approaches, such as bronchodilators, inhaled steroids, oxygen therapy, antibiotics, antihistamines, nasal steroids, decongestants, intranasal drug delivery, neurostimulation, and surgery to treat patients. However, systemic medicines have serious adverse effects, necessitating the development of inhaled formulations that allow precise
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Current Trends in Nanotechnology-based Drug Delivery Systems for the Diagnosis and Treatment of Malaria: A Review Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-24 Rohitas Deshmukh, Bhuvaneshwari Dewangan, Ranjit K. Harwansh, Rutvi Agrawal, Akash Garg, Himansu Chopra
: Malaria is still a major endemic disease transmitted in humans via Plasmodium-infected mosquitoes. The eradication of malarial parasites and the control measures have been rigorously and extensively deployed by local and international health organizations. Malaria's recurrence is a result of the failure to entirely eradicate it. The drawbacks related to malarial chemotherapy, non-specific targeting
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Delivery Systems for Plasma-reactive Species and their Applications in the Field of Biomedicine Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-22 Esmaeil Biazar, Farzaneh Aavani, Reza Zeinali, Bahareh Kheilnezhad, Kiana Taheri, Zahra Yahyaei
: Cold atmospheric plasma (CAP) is an ionized matter with potential applications in various medical fields, ranging from wound healing and disinfection to cancer treatment. CAP's clinical usefulness stems from its ability to act as an adjustable source of reactive oxygen and nitrogen species (RONS), which are known to function as pleiotropic signaling agents within cells. Plasma-activated species,
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Controlled Release of Aspirin in the Body using Pectin-coated ZIF-8 Nanoparticles Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-21 Fatemeh Shahidi, M. Reza Naimi-Jamal, Azizollah Habibi, Mohammad G. Dekamin
Introduction: Zeolitic imidazolate frameworks (ZIFs) play a crucial role among metalorganic frameworks due to their highly desirable properties, including high surface area, appropriate pore size, and excellent thermal and chemical stability. Method: In this study, ZIF-8 loaded with aspirin and coated using pectin (ZIF-8/Asp@Pectin) was utilized as a suitable and effective platform for the drug delivery
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Transdermal Drug Delivery System of Linagliptin Sustained-release Microparticle Gels: In vitro Characterization and In vivo Evaluation Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-21 Jiayan Liu, Song Guo, Shuai Hong, Jingshu Piao, Mingguan Piao
Background: Linagliptin (LNG) exhibits poor bioavailability and numerous side effects, significantly limiting its use. Transdermal drug delivery systems (TDDS) offer a potential solution to overcome the first-pass effect and gastrointestinal reactions associated with oral formulations. Objective: The aim of this study was to develop LNG microparticle gels to enhance drug bioavailability and mitigate
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Dextran-based Drug Delivery Approaches for Lung Diseases: A Review Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-21 Manisha Kumari, Sanyam Sharma, Navjot Kanwar, Subh Naman, Ashish Baldi
: Respiratory disorders, such as tuberculosis, cystic fibrosis, chronic obstructive pulmonary disease, asthma, lung cancer, and pulmonary inflammation, are among the most prevalent ailments in today’s world. Dextran, an exopolysaccharide formed by Leuconostoc mesenteroides (slimeproducing bacteria), and its derivatives are investigated for several therapeutic utilities. Dextranbased drug delivery system
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A Comprehensive Review on Niosomes as a Strategy in Targeted Drug Delivery: Pharmaceutical, and Herbal Cosmetic Applications Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-17 Sakshi Saharawat, Sushma Verma
: Niosomes are newly developed, self-assembling sac-like transporters that deliver medication at a specific site in a focused manner, increasing availability in the body and prolonging healing effects. Niosome discovery has increased drugs’ therapeutic effectiveness while also reducing adverse effects. This article aims to concentrate on the increase in the worldwide utilization of niosomal formulation
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Synergistic Antibacterial Effect of ZnO Nanoparticles and Antibiotics against Multidrug-Resistant Biofilm Bacteria Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-17 Majed M. Masadeh, Noor M. Bany-Ali, Mai S. Khanfar, Karem H. Alzoubi, Majd M. Massadeh, Enaam M. Almomani
Background: The misuse of antibiotics leads to a global increase in antibiotic resistance. Therefore, it is imperative to search for alternative compounds to conventional antibiotics. ZnO nanoparticles (Zn NP) are one of these alternatives because they are an effective option to overcome biofilm bacterial cells and a novel way to overcome multidrug resistance in bacteria. The current research study
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Nanostructured Lipid Carrier-mediated Transdermal Delivery System of Glibenclamide for Gestational Diabetes: Pharmacokinetic and Pharmacodynamic Evaluation Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-12 Ashwini M, Preethi Sudheer, Bharani S. Sogali
Background: Gestational diabetes mellitus (GDM) poses significant risks during pregnancy for both mother and fetus. Adherence to oral antidiabetic medications, like glibenclamide (GB), can be challenging, necessitating novel drug delivery methods. Nanostructured lipid carriers (NLC) offer a promising approach by efficiently permeating the skin due to their small size and lipid-based composition. Objective:
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From Vision Correction to Drug Delivery: Unraveling the Potential of Therapeutic Contact Lens Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-12 Ankush Saini, Mohit Sharma, Indu Singh, Rajan Swami
: Contact lenses (CLs) have become an essential tool in ocular drug delivery, providing effective treatment options for specific eye conditions. In recent advancements, Therapeutic CLs (TCLs) have emerged as a promising approach for maintaining therapeutic drug concentrations on the eye surface. TCLs offer unique attributes, including prolonged wear and a remarkable ability to enhance the bioavailability
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Novel Products as Promising Therapeutic Agents for Angiogenesis Inhibition Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-11 Shaheen Sultana, Shahnaz Sultana, Shehla Nasar Mir Najib Ullah, Ameeduzzafar Zafar
Objective: Angiogenesis is the process of forming new blood vessels from pre-existing vessels and occurs during development, wound healing, and tumor growth. In this review, we aimed to present a comprehensive view of various factors contributing to angiogenesis during carcinogenesis. Anti-angiogenesis agents prevent or slow down cancer growth by interrupting the nutrients and blood supply to the tumor
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TPGS-mediated Transethosomes Enhance Transdermal Administration of Curcumin via Effects on Deformability and Stability Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-11 Teng Guo, Chenming Zhang, Yuling Chen, Yihan Wu, Zhenda Liu, Yongtai Zhang, Nianping Feng
Background: Adding a suitable surfactant can enhance the transdermal permeability of transethosomes while also leveraging its functionality as a functional material. In this study, transethosomes were prepared using D-α-tocopherol acid polyethylene glycol succinate (TPGS) as edge activators for transdermal delivery of curcumin (Cur). Methods: The TPGS-mediated curcumin-loaded transethosomes (Cur@TES)
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Overcoming Skin Barrier with Transfersomes: Opportunities, Challenges, and Applications Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-05 Bhupendra Dixena, Rashmi Madhariya, Anupama Panday, Alpana Ram, Akhlesh K. Jain
Background: Transdermal drug delivery systems (TDDS) offer several advantages over traditional methods like injections and oral administration, including preventing first-pass metabolism, providing consistent and sustained activity, reducing side effects, enabling the use of short halflife drugs, improving physiological response, and enhancing patient convenience. However, the permeability of skin
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Recent Advancements in Bioelectronic Medicine: A Review Curr. Drug Deliv. (IF 2.4) Pub Date : 2024-01-04 Sudipta Das, Baishali Ghosh, Rudra Narayan Sahoo, Amit Kumar Nayak
:: Bioelectronic medicine is a multidisciplinary field that combines molecular medicine, neurology, engineering, and computer science to design devices for diagnosing and treating diseases. The advancements in bioelectronic medicine can improve the precision and personalization of illness treatment. Bioelectronic medicine can produce, suppress, and measure electrical activity in excitable tissue. Bioelectronic
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Liposomal Doxorubicin In vitro and In vivo Assays in Non-small Cell Lung Cancer: A Systematic Review Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-12-15 Pablo Redruello-Guerrero, Paula Cordoba, Antonio Láinez-Ramos-Bossini, Mario Rivera, Cristina Mesas, Raul Ortiz, Jose Prados, Gloria Perazzoli
Background: Liposomal Doxorubicin (Doxil®) was one of the first nanoformulations approved for the treatment of solid tumors. Although there is already extensive experience in its use for different tumors, there is currently no grouped evidence of its therapeutic benefits in non-small cell lung cancer (NSCLC). A systematic review of the literature was performed on the therapeutic effectiveness and benefits
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Recent trends in nanoparticulate delivery system for amygdalin as potential therapeutic herbal bioactive agent for cancer treatment Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-12-01 Mahendra Prajapati, Dr. Rohitas Deshmukh, Dr. Ranjit K. Harwansh
Cancer is the deadliest and most serious health problem. The mortality rate of cancer patients has increased significantly worldwide in recent years. There are several treatments available, but these treatments have many limitations, such as non-specific targeting, toxicity, bioavailability, solubility and permeability problems, serious side effects, and a higher dose. Many people prefer phytomedicine
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WITHDRAWN: Long-time-released Transdermal Microneedle Delivery System Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-11-29 Xiaofei Tang, Huaiying Qin, Xiaoyun Zhang, Haiyun Yang, Jianhua Yang, Ping Chen, Yinli Jin, Lu Yang
The article has been withdrawn at the request of the authors of the journal "Current Drug Delivery", Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts
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Targeted Polymeric Nanoparticles as a Strategy for the Treatment of Glioblastoma: A Review Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-11-28 Geanne Aparecida de Paula, Mariana Carlomagno de Paula, Jessyca Aparecida Paes Dutra, Suzana Gonçalves Carvalho, Leonardo Delello Di Filippo, Janaína Cecília Oliveira Villanova, Marlus Chorilli
: Glioblastoma multiforme is the most common and aggressive malignant tumor that affects the central nervous system, with high mortality and low survival. Glioblastoma multiforme treatment includes resection tumor surgery, followed by radiotherapy and chemotherapy adjuvants. However, the drugs used in chemotherapy present some limitations, such as the difficulty of crossing the bloodbrain barrier and
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Amlodipine Ocular Delivery Restores Ferning Patterns and Reduces Intensity of Glycosylated Peak of Carrageenan-Induced Tear Fluid: An InSilico Flexible Docking with IL-Β1 Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-11-06 Ashirbad Nanda, Rudra Narayan Sahoo, Mahendra Gour, Sandeep Kumar Swain, Debajyoti Das, Amit Kumar Nayak, Subrata Mallick
Background: The tear ferning test can be an easy clinical procedure for the evaluation and characterization of the ocular tear film Objective: The objective of this study was to examine the restoration of tear ferning pattern and reduction of glycosylation peak after amlodipine application in carrageenan-induced conjunctivitis. Methods: At the rabbit’s upper palpebral region, carrageenan was injected
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Development of Polyvinyl Alcohol/Polyethylene Glycol Copolymer-based Orodispersible Films Loaded with Entecavir: Formulation and In vitro Characterization Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-11-06 Teng Wei, Bing-yu ZHOU, Xin-Hong Wu, Xue-Ai Liu, Ming-Wei Huo, Xiang-Xiang Huang, Ling-Zhi Shi, Li-Li Shi, Qing-Ri Cao
Purpose: The aim of the study is to prepare entecavir (ETV)-loaded orodispersible films (ODFs) using polyvinyl alcohol (PVA)/polyethylene glycol (PEG) graft copolymer (Kollicoat® IR) as a film-forming agent, and further to evaluate the dissolution rate, mechanical and physicochemical properties of films. Methods: ETV-ODFs were prepared by a solvent casting method. The amount of film-forming agent,
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Customizable Microfluidic Devices: Progress, Constraints, and Future Advances Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-11-06 Alaa A. A. Aljabali, Mohammad A. Obeid, Vijay Mishra, Mohamed El-Tanani, Murtaza M. Tambuwala
: The field of microfluidics encompasses the study of fluid behavior within micro-channels and the development of miniature systems featuring internal compartments or passageways tailored for fluid control and manipulation. Microfluidic devices capitalize on the unique chemical and physical properties exhibited by fluids at the microscopic scale. In contrast to their larger counterparts, microfluidic
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Mechanism of Action and Related Natural Regulators of Nrf2 in Nonalcoholic Fatty Liver Disease Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-11-06 Wenfei Yu, Decheng Meng, Xin Zhang, Yanan Feng, Guoliang Yin, Pengpeng Liang, Suwen Chen, Hongshuai Liu, Fengxia Zhang
:: With the acceleration of people's pace of life, non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the world, which greatly threatens people's health and safety. Therefore, there is still an urgent need for higher-quality research and treatment in this area. Nuclear factor Red-2-related factor 2 (Nrf2), as a key transcription factor in the regulation of
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Supersaturation Behavior: Investigation of Polymers Impact on Nucleation Kinetic Profile for Rationalizing the Polymeric Precipitation Inhibitors Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-11-01 Uditi Handa, Anuj Malik, Kumar Guarve, Nidhi Rani, Prerna Sharma
Background: Although nucleation kinetic data is quite important for the concept of supersaturation behavior, its part in rationalizing the crystallization inhibitor has not been well understood. Objective: This study aimed to investigate the nucleation kinetic profile of Dextromethorphan HBr (as an ideal drug, BCS-II) by measuring liquid-liquid phase segregation, nucleation induction time, and Metastable
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Recent Updates in Inhalable Drug Delivery System against Various Pulmonary Diseases: Challenges and Future Perspectives Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-10-23 Kabi Raj Chaudhary, Karanvir Singh, Charan Singh
: In the current scenario, pulmonary disease has become a prime burden for morbidity and mortality alongside tremendous social and economic crises throughout the world. Numerous conventional drug delivery system and treatment approach targeting the respiratory region has been driven out. However, effective and accurate recovery has not been achieved yet. In this regard, nanotechnological-based inhalable
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Cellulose Acetate-Based Wound Dressings Loaded with Bioactive Agents: Potential Scaffolds for Wound Dressing and Skin Regeneration Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-10-11 Sindi P. Ndlovu, Sibusiso Alven, Kula Hlalisa, Blessing A. Aderibigbe
Wound healing and skin regeneration are major challenges in chronic wounds. Among the types of wound dressing products currently available in the market, each wound dressing material is designed for a specific wound type. Some of these products suffer from various shortcomings, such as poor antibacterial efficacy and mechanical performance, inability to provide a moist environment, poor permeability
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Research Progress on Immunomodulatory Effects of Poly (Lactic-co-Glycolic Acid) Nanoparticles Loaded with Traditional Chinese Medicine Monomers Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-10-11 Bocui Song, Qian Chen, Chunyu Tong, Yuqi Li, Shuang Li, Xue Shen, Wenqi Niu, Meihan Hao, Yunfei Ma, Yanhong Wang
: Immunomodulatory mechanisms are indispensable and key factors in maintaining the balance of the environment in humans. When the immune function of the immune system is impaired, autoimmune diseases occur. Excessive body fatigue, natural aging of the human body, malnutrition, genetic factors and other reasons cause low immune function, due to which the body is prone to being infected by bacteria or
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Deciphering the Therapeutic Applications of Nanomedicine in Ovarian Cancer Therapy: An Overview Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-10-10 Pooja Mathur, Shailendra Bhatt, Suresh Kumar, Sweta Kamboj, Rohit Kamboj, Arpana Rana, Harish Kumar, Ravinder Verma
The majority of deadly cancers that afflict the female reproductive system occur in the ovary. Around 1,40,000 women worldwide die from ovarian cancer each year, making it the sixth most common cancer-associated deceases among females in the United States. Modern, cutting-edge treatments like chemotherapy and surgery frequently produce full remissions, but the recurrence rate is still very high. When
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A Comprehensive Review on Imperative Role of Ionic Liquids in Pharmaceutical Sciences Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-10-09 Prerna Uniyal, Shibam Das, Surbhi Panwar, Neelima Kukreti, Pankaj Nainwal, Rohit Bhatia
Ionic liquids (ILs) are poorly-coordinated ionic salts that can exist as a liquid at room temperatures (or
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3D Printed Personalized Colon-targeted Tablets: A Novel Approach in Ulcerative Colitis Management Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-10-09 Yachana Mishra, Vijay Mishra, Alaa A.A. Aljabali, Mohamed El-Tanani, Gowhar A. Naikoo, Nitin Charbe, Sai Raghuveer Chava, Murtaza M. Tambuwala
Ulcerative colitis (UC) and Crohn's disease (CD) are two types of idiopathic inflammatory bowel disease (IBD) that are increasing in frequency and incidence worldwide, particularly in highly industrialized countries. Conventional tablets struggle to effectively deliver anti-inflammatory drugs since the inflammation is localized in different areas of the colon in each patient. The goal of 3D printing
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Investigation of Antioxidant and Anti-inflammatory Properties of Berberine Nanomicelles: In vitro and In vivo Studies Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-10-06 Marjan Heidarzadeh, Mehriar Amininasab, Seyed Mahdi Rezayat, Seyyedeh Elaheh Mousavi
Introduction: In the present study, neuroprotective effects of berberine (BBR) and berberine nanomicelle (BBR-NM) against lipopolysaccharides (LPS)-induced stress oxidative were investigated, and compared by evaluating their antioxidant and anti-inflammatory activities in PC12 cells, and rat brains. A fast, green, and simple synthesis method was used to prepare BBR-NMs. Method: The prepared BBR-NMs
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Nanoformulations Insights: A Novel Paradigm for Antifungal Therapies and Future Perspectives Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-10-05 Ashima Ahuja, Meenakshi Bajpai
Currently, fungal infections are becoming more prevalent worldwide. Subsequently, many antifungal agents are available to cure diseases like pemphigus, athlete’s foot, acne, psoriasis, hyperpigmentation, albinism, and skin cancer. Still, they fall short due to pitfalls in physiochemical properties. Conventional medications like lotion, creams, ointments, poultices, and gels are available for antifungal
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A Review on Novel Applications of Nanotechnology in the Management of Prostate Cancer Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-10-04 Arshi Khanam, Gurvirender Singh, Smita Narwal, Bhawna K. Chopra, Ashwani Dhingra
Background: Prostate cancer continues to be a serious danger to men's health, despite advances in the field of cancer nanotechnology. Although different types of cancer have been studied using nanomaterials and theranostic systems derived from nanomaterials, they have not yet reached their full potential for prostate cancer due to issues with in vivo biologic compatibility, immune reaction responses
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Extraction, characterization and controlled release application of pectin-like/chitosan hydrogels system loaded Ciprofloxacin Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-09-08 Amer Rashid Hameed, Zeineb Mzoughi, Mariem Itaimi Dammak, Fawzi Habeeb Jabrail, Didier Le Cerf, Hatem Majdoub
INTRODUCTION: In recent decades, drug delivery applications have extensively utilized hydrogel systems based on natural polymers. Among the numerous biopolymer-based hydrogel drug delivery systems reported, a novel pectin-like substance was extracted from fig leaves and copolymerized with chitosan. METHOD: The hydrogel was reformed into microspheres using glutaraldehyde (chemical cross-linker) and
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Role of Artificial Intelligence in Drug Discovery and Target Identification in Cancer Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-09-06 Vishal Sharma, Amit Singh, Sanjana Chauhan, Pramod Kumar Sharma, Shubham Chaudhary, Astha Sharma, Omji Porwal, Neeraj Kumar Fuloria
Drug discovery and development (DDD) is a highly complex process that necessitates precise monitoring and extensive data analysis at each stage. Furthermore, the DDD process is both timeconsuming and costly. To tackle these concerns, artificial intelligence (AI) technology can be used, which facilitates rapid and precise analysis of extensive datasets within a limited timeframe. The pathophysiology
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An Insight on Skin Cancer About Different Targets With Update on Clinical Trials and Investigational Drugs Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-09-06 Suraj Vishwas, Swarnali Das Paul, Deepika Singh
Cancer is a diverse disease caused by transcriptional changes involving genetic and epigenetic features that influence a huge variety of genes and proteins. Skin cancer is a potentially fatal disease that affects equally men and women globally and is characterized by many molecular changes. Despite the availability of various improved approaches for detecting and treating skin cancer, it continues
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A Novel Phytotherapy Application: Preparation, Characterization, Antioxidant Activities and Determination of Anti-inflammatory Effects by In vivo HET-CAM Assay of Chitosan-based DDSs Containing Endemic Helichrysum pamphylicum P.H. Davis & Kupicha Methanolic Extract Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-09-04 Nurlan Ismailovi, H. Tuba Kıyan, A. Alper Öztürk
Background: Numerous pharmaceutical applications for chitosan, a polysaccharide made from the shells of crustaceans by deacetylating chitin that occurs naturally, are currently being researched. Chitosan, a natural polymer, is successfully used to prepare many drug-carrier systems, such as gel, film, nanoparticle, and wound dressing. Objective: Preparing chitosan gels without external crosslinkers
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Enhancing Oral Bioavailability of Domperidone Maleate: Formulation, In vitro Permeability Evaluation In-caco-2 Cell Monolayers and In situ Rat Intestinal Permeability Studies Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-09-04 Neslihan Üstündağ Okur, Emre Şefik Çağlar, Mustafa Sinan Kaynak, Mine Diril, Saniye Özcan, Hatice Yeşim Karasulu
Background: The domperidone maleate, a lipophilic agent classified as a Biopharmaceutical Classification System Class II substance with weak water solubility. Self- Emulsifying Drug Delivery System is a novel approach to improve water solubility and, ultimately bioavailability of drugs. Objective: This study aimed to develop and characterize new domperidone-loaded self-emulsifying drug delivery systems
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Exploring Applications of Flexible Vesicular Systems as Transdermal Drug Delivery Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-08-31 Palwinder Kaur, Surajpal Verma, Bhupendra Tomar, Manish Vyas, Violina Kakoty, Paramita Saha, Sarathlal KC
: Deformable lipidic-nano carriers are a category of advanced liposomal formulations. Deformable lipidic-nano carriers have a specific character to transform by rearranging the lipidic backbone to squeeze themself through a pore opening ten times smaller than their diameter when exposed to a variable condition like hydration gradient as these have potentially been used as a non-invasive delivery system
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Nano-platform Strategies of Herbal Components for the management of Rheumatoid Arthritis: A Review on the Battle for Next-Generation Formulations Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-08-25 Amit Bhatia, Jyoti Prabha, Mohit Kumar, Devesh Kumar, Shruti Chopra
Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that initially affects small joints and then spreads to the bigger joints. It also affects other organs of the body such as the lungs, eyes, kidneys, heart, and skin. In RA, there is destruction of cartilage and joints, and ligaments and tendons become brittle. Damage to the joints leads to abnormalities and bone degradation
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Novel Vesicular Bilosomal Delivery Systems for Dermal/Transdermal Applications Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-08-24 Vasanti Suvarna, Rashmi Mallya, Kajal Deshmukh, Bhakti Sawant, Tabassum Asif Khan, Abdelwahab Omri
The application of therapeutically active molecules through the dermal/transdermal route into the skin has evolved as an attractive formulation strategy in comparison to oral delivery systems for the treatment of various disease conditions. However, the delivery of drugs across the skin is limited due to poor permeability. Dermal/transdermal delivery is associated with ease of accessibility, enhanced
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Dysprosium-containing cobalt sulfide nanoparticles as anticancer drug carriers Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-08-18 Govindaraj Sri Varalakshmi, Charan Singh Pawar, Varnitha Manikantan, Archana Sumohan Pillai, Aleyamma Alexander, Bose Allben Akash, N. Rajendra Prasad, Israel V. M. V. Enoch
Background: Among various materials designed for anticancer drug transport, sulfide nanoparticles are uniquely intriguing owing to their spectral characteristics. Exploration of newer nanoscale copper sulfide particles with dysprosium doping is reported herein. It leads to a change in the physicochemical properties of the sulfide nanoparticles and hence the difference in drug release and cytotoxicity
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A Novel Etanercept-Loaded Nano-emulsion for Targeted Treatment of Inflammatory Arthritis via Draining Lymph Node Curr. Drug Deliv. (IF 2.4) Pub Date : 2023-08-11 Chenglong Li, Guanting lu, Yue Jiang, Huaiyu Su, Chen Li
Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease (AD), and the global incidence rate is 0.5 ~ 1%. Existing medications might reduce symptoms, however, there is no known cure for this illness. Etanercept (EN) can competitively inhibit TNF-α binding to the TNF receptor on the cell surface to treat RA. However, subcutaneous injection of free EN predisposes to systemic distribution