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Prognostic Nutritional Index Predicts Efficacy and Immune-Related Adverse Events of First-Line Chemoimmunotherapy in Patients with Extensive-Stage Small-Cell Lung Cancer J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-18 Baishen Zhang, Jing Chen, Hui Yu, Meichen Li, Muyan Cai, Likun Chen
Background: Currently, there is a lack of well-established markers to predict the efficacy of chemoimmunotherapy in small-cell lung cancer (SCLC). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), advanced lung cancer inflammation index (ALI) and prognostic nutritional index (PNI) are associated with prognosis in several tumors, whereas their predictive role in SCLC remains
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CSF Findings in Chinese Patients with NMDAR, LGI1 and GABABR Antibody-Associated Encephalitis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-18 Shan Qiao, Haiyun Li, Caisan Cui, Chong Zhang, Aihua Wang, Wenjing Jiang, Shanchao Zhang
Purpose: CSF inflammation in subtypes of antibody-defined autoimmune encephalitis (AE) ranges in intensity from moderate to severe. In a retrospective, cross-sectional study, we characterized CSF findings in Chinese patients with anti-N-methyl-D-aspartate receptor encephalitis (NMDAR-E), anti-leucine-rich glioma-inactivated 1 encephalitis (LGI1-E), and anti-gamma aminobutyric acid-B receptor encephalitis
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High Level of Serum Complement C3 Expression is Associated with Postoperative Vasculopathy Progression in Moyamoya Disease J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-18 Min-Jie Wang, Jiayu Wang, Houdi Zhang, Fang-Bin Hao, Gan Gao, Si-Meng Liu, Xiao-Peng Wang, Jing-Jie Li, Zheng-Xing Zou, Qing-Bao Guo, He-Guan Fu, Yi-Qin Han, Cong Han, Lian Duan
Background: The immune system plays an important role in the onset and development of moyamoya disease (MMD), but the specific mechanisms remain unclear. This study aimed to explore the relationship between the expression of complements and immunoglobulin in serum and progression of MMD. Methods: A total of 84 patients with MMD and 70 healthy individuals were enrolled. Serum immunoglobulin and complement
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Lactobacillus Plantarum Promotes Wound Healing by Inhibiting the NLRP3 Inflammasome and Pyroptosis Activation in Diabetic Foot Wounds J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-16 Xiaojun Wang, Xu Li, Jianjun Liu, Yue Tao, Tao Wang, Limeng Li
Objective: Diabetic foot ulcer (DFU) impairs the quality of life of diabetic patients and overburdens healthcare systems and society. It is crucial to comprehend the pathophysiology of DFU and develop effective treatment strategies. The aim of this study was to to evaluate the therapeutic potential of Lactobacillus Plantarum (LP) on wound healing in DFU and to explore the underlying mechanisms. Methods:
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Envoplakin Inhibits Macrophage Polarization by Altering the Inflammatory Tumor Microenvironment of Melanoma Through the RAS / ERK Signaling Pathway J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-15 Weilin Cai, Minliang Chen
Purpose: Tumor growth induces the tumor margin to become a transition zone rich in immune cells. EVPL is a potential prognostic biomarker for melanoma. Melanoma is difficult to cure because of its high metastasis, so it is urgent to find effective genes to inhibit tumor progression and regulate tumor microenvironment. Methods: Firstly, differentially expressed genes (DEGs) among normal skin, nevus
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Serum Homer1 is a Novel Biomarker for Predicting the Clinical Outcomes of Acute Ischemic Stroke Patients [Letter] J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-15 Jumraini Tammasse
Letter for the article Serum Homer1 is a Novel Biomarker for Predicting the Clinical Outcomes of Acute Ischemic Stroke Patients
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Identification of VRK1 as a Novel Potential Biomarker for Prognosis and Immunotherapy in Hepatocellular Carcinoma J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-14 Xiaoyan He, Guozhen Zai, Lidan Zhou, Shengyang Chen, Guizhi Wang
Background: Research has indicated that VRK1 is essential for the tumor cell cycle. However, its prognostic and immunotherapeutic predictive significance has not been documented in hepatocellular carcinoma (HCC). Methods: The TCGA, ICGC, and GSE14520 datasets were used to investigate VRK1 expression and its predictive significance of survival outcomes. The qRT-PCR and immunohistochemistry (IHC) were
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Predictive and Prognostic Potentials of Lymphocyte-C-Reactive Protein Ratio Upon Hospitalization in Adult Patients with Acute Pancreatitis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-13 Xiao-Yu Xu, Yang Gao, Chuang-Shi Yue, Yu-Jia Tang, Zhao-Jin Zhang, Feng-Jie Xie, Hong Zhang, Yu-Cheng Zhu, Yan Zhang, Qi-Qi Lai, Xin-Tong Wang, Jia-Xi Xu, Jia-Ning Zhang, Bo-Wen Liu, Jian-Nan Zhang, Kai Kang
Purpose: In this study, our objective was to investigate the potential utility of lymphocyte-C-reactive protein ratio (LCR) as a predictor of disease progression and a screening tool for intensive care unit (ICU) admission in adult patients with acute pancreatitis (AP). Methods: We included a total of 217 adult patients with AP who were admitted to the First Affiliated Hospital of Harbin Medical University
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Pretreated MSCs with IronQ Transplantation Attenuate Microglia Neuroinflammation via the cGAS-STING Signaling Pathway J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-13 Guoqiang Yang, Jiraporn Kantapan, Maryam Mazhar, Qiongdan Hu, Xue Bai, Yuanxia Zou, Honglian Wang, Sijin Yang, Li Wang, Nathupakorn Dechsupa
Background: Intracerebral hemorrhage (ICH), a devastating form of stroke, is characterized by elevated morbidity and mortality rates. Neuroinflammation is a common occurrence following ICH. Mesenchymal stem cells (MSCs) have exhibited potential in treating brain diseases due to their anti-inflammatory properties. However, the therapeutic efficacy of MSCs is limited by the intense inflammatory response
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The Critical Role of Pyroptosis in Peri-Implantitis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-12 Liangwen Chen, Ziqiao Tang, Liangliang Fu, Yang Xie, Junyi Xu, Haibin Xia, Ting Xia, Min Wang
Background: Peri-implantitis (PI) is a prevalent complication of implant treatment. Pyroptosis, a distinctive inflammatory programmed cell death, is crucial to the pathophysiology of PI. Despite its importance, the pyroptosis-related genes (PRGs) influencing PI’s progression remain largely unexplored. Methods: This study conducted histological staining and transcriptome analyze from three datasets
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The Function and Mechanism of Anti-Inflammatory Factor Metrnl Prevents the Progression of Inflammatory-Mediated Pathological Bone Osteolytic Diseases J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-11 Nan Liu, Jinlei Dong, Lianxin Li, Dongsheng Zhou, Fanxiao Liu
Abstract: Metrnl, recently identified as an adipokine, is a secreted protein notably expressed in white adipose tissue, barrier tissues, and activated macrophages. This adipokine plays a pivotal role in counteracting obesity-induced insulin resistance. It enhances adipose tissue functionality by promoting adipocyte differentiation, activating metabolic pathways, and exerting anti-inflammatory effects
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Caffeine in Hepatocellular Carcinoma: Cellular Assays, Animal Experiments, and Epidemiological Investigation J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-11 Liang Shan, Ning Zhao, Fengling Wang, Dandan Zhai, Jianjun Liu, Xiongwen Lv
Abstract: The use of caffeine in treating various liver diseases has made substantial progress in the past decade owing to advances in science, technology, and medicine. However, whether caffeine has a preventive effect on hepatocellular carcinoma (HCC) and its mechanism are still worth further investigation. In this review, we summarize and analyze the efficacy and safety of caffeine in the prevention
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The Impact of Laparoscopic Appendectomy and Open Appendectomy on B7-H3-Mediated Intrinsic Immune Response in Children with Acute Suppurative Appendicitis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-11 Chunsheng Duan, Yuan Li, Jiansu Ma, Yanglin Song, Lixia Zhou
Purpose: Surgery impairs immune function and increases postoperative complications. B7H3, a co-stimulatory molecule, plays a crucial role in immune regulation. The present study examined the impact of B7H3 on the postoperative immune response in children with acute suppurative appendicitis (ASA) by comparing preoperative and postoperative B7H3 levels in laparoscopic surgery (LA) and open appendectomy
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Integrated Bioinformatics Exploration and Preliminary Clinical Verification for the Identification of Crucial Biomarkers in Severe Cases of COVID-19 J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-11 Zhisheng Huang, Zuowang Cheng, Xia Deng, Ying Yang, Na Sun, Peibin Hou, Ruyue Fan, Shuai Liu
Background: Coronavirus disease 2019 (COVID-19) is a respiratory infectious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The objective of this study is to identify reliable and accurate biomarkers for the early stratification of disease severity, a crucial aspect that is currently lacking for the impending phases of the next COVID-19 pandemic. Methods: In this study
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A Nomogram for Predicting Mortality in Patients with Pneumonia-Associated Acute Respiratory Distress Syndrome (ARDS) J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-08 Dong Huang, Dingxiu He, Linjing Gong, Wei Jiang, Rong Yao, Zongan Liang
Background: There is no predictive tool developed for pneumonia-associated acute respiratory distress syndrome (ARDS) specifically so far, and the clinical risk classification of these patients is not well defined. Our study aims to construct an early prediction model for hospital mortality in patients with pneumonia-associated ARDS. Methods: In this single-center retrospective study, consecutive patients
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scRNA-Seq and Bulk-Seq Analysis Identifies S100A9 Plasma Cells as a Potentially Effective Immunotherapeutic Agent for Multiple Myeloma J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-09 Xinyi Long, Fangfang Li, Sishi Tang, Jing Liu, Yunfeng Fu, Yanhui Feng
Purpose: Immunological regimens are an important area of research for treating multiple myeloma (MM). Plasma cells play a crucial role in immunotherapy. Patients and Methods: In our study, we used both single-cell RNA sequencing (scRNA-seq) and bulk sequencing techniques to analyze MM patients. We analyzed each sample using gene set variation analysis (GSVA) based on immune-related gene sets. We also
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Comprehensive Nomograms Using Routine Biomarkers Beyond Eosinophil Levels: Enhancing Predictability of Corticosteroid Treatment Outcomes in AECOPD J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-08 Lin Feng, Jiachen Li, Zhenbei Qian, Chenglong Li, Darui Gao, Yongqian Wang, Wuxiang Xie, Yutong Cai, Zhaohui Tong, Lirong Liang
Purpose: Patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) exhibit heterogeneous responses to corticosteroid treatment. We aimed to determine whether combining eosinophil levels with other routine clinical indicators can enhance the predictability of corticosteroid treatment outcomes and to come up with a scoring system. Patients and Methods: Consecutive patients admitted
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Prognostic Value of Macrophage Inflammatory Protein-3alpha (MIP3-Alpha) and Severity Scores in Elderly Patients with Sepsis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-08 Min Liu, Yun-Jiao Duan, Ye Zhang, Jun Yang, Bing Wei, Junyu Wang
Objective: This study examines the effectiveness of MIP-3alpha and severity scores in determining the prognosis of elderly sepsis patients. Methods: From October 2020 to April 2021, a total of 171 elderly sepsis patients were admitted to the Emergency Department of the Shijingshan Branch of Beijing Chaoyang Hospital, Capital Medical University. According to the 28-day mortality rate, they were divided
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The Mechanism of Pyroptosis and Its Application Prospect in Diabetic Wound Healing J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-06 Abdullah Al Mamun, Chuxiao Shao, Peiwu Geng, Shuanghu Wang, Jian Xiao
Abstract: Pyroptosis defines a form of pro-inflammatory-dependent programmed cell death triggered by gasdermin proteins, which creates cytoplasmic pores and promotes the activation and accumulation of immune cells by releasing several pro-inflammatory mediators and immunogenic substances upon cell rupture. Pyroptosis comprises canonical (mediated by Caspase-1) and non-canonical (mediated by Caspase-4/5/11)
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Investigation of the miRNA-mRNA Regulatory Circuits and Immune Signatures Associated with Bronchopulmonary Dysplasia J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-05 Sen Li, Shuling Liang, Shunyu Xie, Haixia Chen, Haoying Huang, Qixin He, Huayan Zhang, Xiaohui Wang
Background: Bronchopulmonary dysplasia (BPD) has become a major cause of morbidity and mortality in preterm infants worldwide, yet its pathogenesis and underlying mechanisms remain poorly understood. The present study sought to explore microRNA-mRNA regulatory networks and immune cells involvement in BPD through a combination of bioinformatic analysis and experimental validation. Methods: MicroRNA
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A Risk Score Based on Immune- and Oxidative Stress-Related LncRNAs Predicts Prognosis in Lung Adenocarcinoma: Insights from in vitro Experiments and Large-Scale Transcriptome Analysis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-05 Xin Liu, Fangchao Zhao, Xiaodan Wang, Zheng Ma, Hongjiang Yan, Xuchao Lu, Shujun Li, Haiyong Zhu, Shaolin Gao
Background: Long non-coding RNAs (lncRNAs) were demonstrated to be key to cancer progression and highly associated with the tumor immune microenvironment. Oxidative stress and immune may modulate the biological behaviors of tumors. Therefore, biomarkers that combined oxidative stress, immune, and lncRNA can be a promising candidate bioindicator in clinical therapy of cancers. Methods: Immune-related
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Machine Learning Predictive Model for Septic Shock in Acute Pancreatitis with Sepsis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-05 Yiqin Xia, Hongyu Long, Qiang Lai, Yiwu Zhou
Objective: Acute pancreatitis (AP) progresses to septic shock can be fatal. Early identification of high-risk patients and timely intervention can prevent and interrupt septic shock. By analyzing the clinical characteristics of AP with sepsis, this study uses machine learning (ML) to build a model for early prediction of septic shock within 28 days of admission, which guided emergency physicians in
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Phenotypes and Lung Microbiota Signatures of Immunocompromised Patients with Pneumonia-Related Acute Respiratory Distress Syndrome J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-01 Yan Hu, Jiawei Shen, Youzhong An, Yanwen Jiang, Huiying Zhao
Objective: We aim to identify the clinical phenotypes of immunocompromised patients with pneumonia-related ARDS, to investigate the lung microbiota signatures and the outcomes of different phenotypes, and finally, to develop a machine learning classifier for a specified phenotype. Methods: This prospective study included immunocompromised patients with pneumonia-related ARDS. We identified phenotypes
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Are Changes in Serum IgG Glycosylation Related to the Severe Course of SARS-CoV-2 Infection and Recovery Process? In Search of New Diagnostic and Prognostic Biomarkers J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-02 Katarzyna Sołkiewicz, Izabela Kokot, Violetta Dymicka-Piekarska, Justyna Dorf, Ewa Maria Kratz
Introduction: Immunoglobulin G (IgG) glycosylation affects its effector functions and is essential in many steps of the inflammatory cascade. Therefore, it may be an important parameter for assessing the body’s immune response during the course of COVID-19 (Coronavirus disease 2019). Methods: The N- and O-glycosylation of serum IgG in severe COVID-19 patients (n=87), convalescents (n=50), and healthy
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Identification and Validation of Genes Related to Macrophage Polarization and Cell Death Modes Under Mycobacterium tuberculosis Infection J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-29 Zisha Yang, Jiajun Wang, Jiang Pi, Di Hu, Junfa Xu, Yi Zhao, Yan Wang
Purpose: To investigate the correlation between M1/M2 macrophages (M1/M2 M&phis) and cell death mode under Mycobacterium tuberculosis (Mtb) infection. Methods: Raw gene expression profiles were collected from the Gene Expression Omnibus (GEO) database. Genes related to different cell death modes were collected from the KEGG, FerrDb and GSEA databases. The differentially expressed genes (DEGs) of the
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Association of Antidiabetic Drug Target Genes with Inflammatory Bowel Disease: A Mendelian Randomization Study J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-29 Xiangli Qing, Lin Wang, Shuangshuang Fang, Yanran Ban, Zhuotai Zhong, Weiqi Sun, Chenhui Zhang, Tao Zhang, Yang Yang, Wei Wei
Background: An unmet medical need for the treatment of inflammatory bowel disease (IBD) exists. A part of antidiabetic drugs had potential effects on IBD in various observational research. Objective: To investigate the potential of antidiabetic drugs on IBD. Methods: We undertook a summary-data-based Mendelian randomization (SMR) using the expression quantitative trait loci (eQTL) expressed in the
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Dynamic Changes and Clinical Significance of Plasma Galectin-3 in Patients with Acute Ischemic Stroke Undergoing Endovascular Therapy J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-01 Mingzheng Yao, Dan Liang, Xiuli Zeng, Xiaomei Xie, Jiali Gao, Li'an Huang
Purpose: Galectin-3 is a key regulator of microglial proliferation and activation and may have dual and time-dependent effects on ischemic stroke. This study aimed to prospectively investigate the dynamic changes in Galectin-3 levels in patients with acute ischemic stroke receiving endovascular therapy and its clinical significance. Patients and Methods: A total of 105 patients with acute ischemic
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A Cohort Study on the Correlation Between Serum Uric Acid Trajectory and New-Onset Hypertension Based on Longitudinal Health Examination Data in Henan Area J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-27 Shifeng Sheng, Jingfeng Chen, Yuheng Zhang, Weikang Li, Feifei Li, Rong Gou, Lin Tang, Suying Ding
Objective: To explore the correlation between serum uric acid (SUA) trajectories and new-onset hypertension, to provide scientific basis for the prevention and treatment of hypertension. Methods: The study cohort was composed of 4372 subjects who met the inclusion criteria in the cohort study of Henan physical examination population. According to the SUA values of the subjects’ physical examination
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Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-27 Miaomiao Sun, Fuquan Wang, Haopeng Li, Mengyu Li, Yu Wang, Chenchen Wang, Yan Zhang, Dingyu Zhang, Jianhua Li, Shanglong Yao
Background: Sepsis-associated acute kidney injury (SA-AKI) is a common complication in patients with sepsis, triggering high morbidity and mortality. Maresin-1 (MaR1) is a pro-resolution lipid mediator that promotes the resolution of acute inflammation and protects organs from inflammation. Methods: In this study, we established an SA-AKI model using cecal ligation and puncture (CLP) and investigated
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Serum Homer1 is a Novel Biomarker for Predicting the Clinical Outcomes of Acute Ischemic Stroke Patients J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-27 Weihao Lv, Zhe Ruan, Qianqian Zhang, Yaxuan Wei, Xiuquan Wu, Ya-Nan Dou, Wangshu Chao, Xiaowei Fei, Zhou Fei
Purpose: We aim to explore the relationship between Homer1 and the outcomes of AIS patients at 3 months. Patients and Methods: This prospective cohort study was conducted from May 2022 to March 2023. In this study, we investigated the association between serum Homer1 levels by enzyme-linked immunosorbent assay at admission and functional outcomes of patients at 3 months after AIS. Results: Overall
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Prognostic Value of Fibrinogen to Prealbumin Ratio (FPR) in Resectable Gastric Cancer J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-27 Hongwei Li, Yufei Sun, Cong Wang, Yingwei Xue
Background: The ratio of fibrinogen to prealbumin (FPR) is associated with the prognosis of many cancers. However, the prognostic significance of FPR in resectable gastric cancer has not been clarified. Methods: A total of 760 patients with resectable gastric cancer participated in this study. The receiver operating characteristic curve (ROC) was used to calculate the optimal cutoff value of each immunonutrition
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Remodeling of Paranasal Sinuses Mucosa Functions in Response to Biofilm-Induced Inflammation J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-26 Szczepan Kaliniak, Krzysztof Fiedoruk, Jakub Spałek, Ewelina Piktel, Bonita Durnaś, Stanisław Góźdź, Robert Bucki, Sławomir Okła
Abstract: Rhinosinusitis (RS) is an acute (ARS) or chronic (CRS) inflammatory disease of the nasal and paranasal sinus mucosa. CRS is a heterogeneous condition characterized by distinct inflammatory patterns (endotypes) and phenotypes associated with the presence (CRSwNP) or absence (CRSsNP) of nasal polyps. Mucosal barrier and mucociliary clearance dysfunction, inflammatory cell infiltration, mucus
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Quercetin Protects Against Global Cerebral ischemia‒reperfusion Injury by Inhibiting Microglial Activation and Polarization J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-26 Naigeng Wang, Fei Li, Jing Du, Jianhong Hao, Xin Wang, Yueru Hou, Zhenguo Luo
Background: This study aims to investigate the protective effect of quercetin against global cerebral ischemia‒reperfusion (GCI/R) injury in rats and elucidate the underlying mechanism. Methods: A GCI/R injury rat model was established using a four-vessel occlusion (4-VO) method. An oxygen–glucose deprivation/reoxygenation (OGD/R) injury model was induced in BV2 cells. The extent of injury was assessed
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BAP31 Promotes Adhesion Between Endothelial Cells and Macrophages Through the NF-κB Signaling Pathway in Sepsis J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-26 Jiawei He, Danyang Jing, Shen Zhao, Meili Duan
Purpose: To investigate the role of B cell receptor associated protein 31 (BAP31) in the pathogenesis of sepsis. Methods: Cecal ligation and puncture (CLP)-induced C57BL/6J mice, and LPS-challenged endothelial cells (HUVECs) were established to mimic a sepsis animal model and a sepsis cell model, respectively. Cre/LoxP and shRNA methods were used for BAP31 knockdown in vivo and in vitro respectively
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Expression and Signiffcance of KIM-1, NGAL, and HO-1 in Patients with Acute Kidney Injury After Cardiac Valve Replacement [Letter] J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-26 Yanyan Song, Jiwei Gu
Letter for the article Expression and Significance of KIM-1, NGAL, and HO-1 in Patients with Acute Kidney Injury After Cardiac Valve Replacement
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The Associations of Two Novel Inflammation Biomarkers, SIRI and SII, with Mortality Risk in Patients with Chronic Heart Failure J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-23 Di Zhu, Chi Wang, You Zhou, Hebin Che, Ruiqing Wang, Liting Cheng, Chongyou Rao, Qin Zhong, Zongren Li, Yongjie Duan, Kunlun He
Background: The associations of two novel inflammation biomarkers, systemic inflammation response index (SIRI) and systemic immune inflammation index (SII), with mortality risk in patients with chronic heart failure (CHF) are not well-characterized. Methods: This retrospective cohort study included patients with CHF in two medical centers of Chinese People’s Liberation Army General Hospital, Beijing
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Sevoflurane Alters Serum Metabolites in Elders and Aging Mice and Increases Inflammation in Hippocampus J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-23 Tingting Wang, Xia Wu, Xiaoli Zhao, Jiaqi Li, Jian Yu, Maozheng Sheng, Mingyuan Gao, Yutang Cao, Jiawen Wang, Xiaozhen Guo, Kai Zeng
Purpose: Postoperative cognitive dysfunction (POCD) is a central nervous system complication that occurs after anesthesia, particularly among the elderly. However, the neurological pathogenesis of postoperative cognitive dysfunction remains unclear. The aim of this study was to evaluate the effects of sevoflurane exposure on serum metabolites and hippocampal gene expression in elderly patients and
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The Ratio of Red Blood Cell Distribution Width to Albumin as a Predictor for Rehospitalization Risk and Rehospitalization All-Cause Mortality in Middle-Aged and Elderly Survivors with Sepsis: An Ambispective ICU Cohort Study J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-22 Yanni Tan, Yameng Li, Xiuxian Huang, Zhenwei Zhai, Qiu Wang, Yanli Guo, Junjun Li, Wensheng Lu
Objective: To explore the relationship between red blood cell distribution width to albumin (RDW/ALB) ratio (RAR) and the risk of rehospitalization and rehospitalization all-cause mortality in middle-aged and elderly survivors with sepsis based on an ambispective longitudinal cohort from the Intensive Care Unit (ICU). Methods: Between 2017 and 2022, 455 adults who survived the first-episode severe
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A Prediction Model Based on Systemic Immune-Inflammatory Index Combined with Other Predictors for Major Adverse Cardiovascular Events in Acute Myocardial Infarction Patients J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-22 Xiaobo Li, Chen Yu, Xuewei Liu, Yejia Chen, Yutian Wang, Hongbin Liang, ShiFeng Qiu, Li Lei, Jiancheng Xiu
Objective: To evaluate the prognostic value of the systemic immune-inflammatory index (SII) for predicting in-hospital major adverse cardiovascular events (MACEs) in patients with acute myocardial infarction (AMI) and establish a relevant nomogram. Methods: This study included 954 AMI patients. We examined three inflammatory factors (SII, platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte
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Clinical Efficacy and Mechanism of Vitamin D2 in Treating Hashimoto’s Thyroiditis J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-22 Lu Gan, Yuqi Li
Objective: Hashimoto’s thyroiditis (HT) is one of the most common autoimmune diseases, with the highest incidence rate among autoimmune thyroid disorders. Vitamin D2 may have therapeutic effects on HT. This study aimed to elucidate the molecular mechanisms underlying vitamin D2 therapy for HT. Methods: Differentially expressed genes (DEGs) associated with vitamin D2-treated HT were identified, and
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Construction and Validation of a Nomogram Model to Predict the Severity of Mycoplasma pneumoniae Pneumonia in Children J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-22 Li Li, Run Guo, Yingxue Zou, Xu Wang, Yifan Wang, Shiying Zhang, Huihua Wang, Xingnan Jin, Ning Zhang
Background: This study aimed to develop a nomogram model for early prediction of the severe Mycoplasma pneumoniae pneumonia (MPP) in children. Methods: A retrospective analysis was conducted on children with MPP, classifying them into severe and general MPP groups. The risk factors for severe MPP were identified using Logistic Stepwise Regression Analysis, followed by Multivariate Regression Analysis
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Actives from the Micro-Immunotherapy Medicine 2LMIREG® Reduce the Expression of Cytokines and Immune-Related Markers Including Interleukin-2 and HLA-II While Modulating Oxidative Stress and Mitochondrial Function J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-21 Camille Jacques, Flora Marchand, Mathias Chatelais, Ilaria Floris
Introduction: Micro-immunotherapy (MI) is a therapeutic option employing low doses (LD) and ultra-low doses (ULD) of cytokines and immune factors to help the organism at modulating the immune responses. In an overpowering inflammatory context, this strategy may support the restoration of the body’s homeostasis, as the active ingredients of MI medicines’ (MIM) could boost or slow down the physiological
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Vitamin K: Infection, Inflammation, and Auto-Immunity J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-20 Yuanyuan Xie, Shifang Li, Dinan Wu, Yining Wang, Jiepeng Chen, Lili Duan, Shuzhuang Li, Yuyuan Li
Abstract: Vitamin K (VK) comprises a group of substances with chlorophyll quinone bioactivity and exists in nature in the form of VK1 and VK2. As its initial recognition originated from the ability to promote blood coagulation, it is known as the coagulation vitamin. However, based on extensive research, VK has shown potential for the prevention and treatment of various diseases. Studies demonstrating
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Predicting Diagnostic Biomarkers Associated with Pyroptosis in Neuropathic Pain Based on Machine Learning and Experimental Validation J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-20 Sheng Tian, Heqing Zheng, Wei Wu, Lanxiang Wu
Purpose: Previous studies have shown that pyroptosis plays a vital role in the progress of neuropathic pain (NP), but the molecular mechanisms have not been fully elucidated. The aim of this study was to identify crucial pyroptosis-related genes (PRGs) in NP. Methods: We identified pyroptosis-related differentially expressed genes (PRDEGs) in NP by machine learning analysis of the GSE24982 and GSE60670
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The Hippo-YAP Signaling Pathway in Osteoarthritis and Rheumatoid Arthritis J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-19 Min Li, Fang-Jie Zhang, Rui-Jun Bai
Abstract: Arthritis is the most prevalent joint disease and is characterized by articular cartilage degradation, synovial inflammation, and changes in periarticular and subchondral bone. Recent studies have reported that Yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) have significant effects on the proliferation, migration, and survival of chondrocytes
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Association Between Number of Missing Teeth and Hyperlipidemia: The TCLSIH Cohort Study J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-17 Feng Qiao, Hong Guo, Jing Zhang, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Yeqing Gu, Kun Song, Changyi Li, Kaijun Niu
Background: To explore the association between the number of missing teeth and the prevalence of hyperlipidemia in a Chinese adult population. Methods: 13,932 adults were investigated in the TCLSIH cohort study. The number of missing teeth was determined at baseline through a self-reported questionnaire, and then classified into three categories: 0, 1– 2, and ≥ 3. We defined hyperlipidemia as total
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Macrophage-Myofibroblast Transition as a Potential Origin for Skeletal Muscle Fibrosis After Injury via Complement System Activation J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-17 Beijie Qi, Yuqi Li, Zhen Peng, Zhiwen Luo, Xingyu Zhang, Jiwu Chen, Guoqi Li, Yaying Sun
Background: Acute skeletal muscle injury is common in sports. The injured muscle cannot fully recover due to fibrosis resulting from myofibroblasts. Understanding the origin of fibroblasts is, therefore, important for the development of anti-fibrotic therapies. Accumulating evidence shows that a mechanism called macrophage-myofibroblast transition (MMT) can lead to tissue or organ fibrosis, yet it
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Microbiome: Role in Inflammatory Skin Diseases J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-15 Xue-Er Zhang, Pai Zheng, Sheng-Zhen Ye, Xiao Ma, E Liu, Yao-Bin Pang, Qing-Ying He, Yu-Xiao Zhang, Wen-Quan Li, Jin-Hao Zeng, Jing Guo
Abstract: As the body’s largest organ, the skin harbors a highly diverse microbiota, playing a crucial role in resisting foreign pathogens, nurturing the immune system, and metabolizing natural products. The dysregulation of human skin microbiota is implicated in immune dysregulation and inflammatory responses. This review delineates the microbial alterations and immune dysregulation features in common
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Transcription Factor IRF7 is Involved in Psoriasis Development and Response to Guselkumab Treatment J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-15 Xiuqing Yuan, Tiantian Xin, Huanhuan Yu, Jian Huang, Yaohan Xu, Caixin Ou, Yongfeng Chen
Purpose: Guselkumab is a highly effective biologic agent for treating psoriasis. This study aimed to explore potential transcription factors involved in psoriasis pathogenesis and response to guselkumab treatment, aiming to provide new therapeutic strategies for psoriasis. Patients and Methods: We analyzed gene expression and single-cell RNA-seq data from the Gene Expression Omnibus (GEO) database
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Inflammation and Neurodegeneration in Glaucoma: Isolated Eye Disease or a Part of a Systemic Disorder? - Serum Proteomic Analysis J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-13 Michał Andrzej Okruszko, Maciej Szabłowski, Mateusz Zarzecki, Magdalena Michnowska-Kobylińska, Łukasz Lisowski, Magda Łapińska, Zofia Stachurska, Anna Szpakowicz, Karol Adam Kamiński, Joanna Konopińska
Introduction: Glaucoma is the most common optic neuropathy and the leading cause of irreversible blindness worldwide, which affects 3.54% of the population aged 40– 80 years. Despite numerous published studies, some aspects of glaucoma pathogenesis, serum biomarkers, and their potential link with other diseases remain unclear. Recent articles have proposed that autoimmune, oxidative stress and inflammation
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miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes [Retraction] J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-14 Yongquan Chen, Yecheng Deng, Linghua Chen, Ziyao Huang, Yi Yan, Zhaoqi Huang
Retraction for the article miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes
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Lipidomics Analysis Deepen Understanding the Molecular Mechanisms in a Gouty Model Induced by Combination of MSU Crystals Injection and High-Fat Diet Feeding and the Intervention Mechanisms of Allopurinol J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-13 Dianming Li, Weiman Shi, Changfeng Hu, Chengping Wen, Lin Huang, Qiao Wang
Background: Gouty arthritis (GA) is a common inflammatory disease caused by deposition of monosodium urate (MSU) crystals in diarthrodial joints. GA attacks commonly involved in joint with red, swollen, heat and pain, and often happened in unilateral foot-first metatarsophalangeal. Accumulated studies have proved that lipids play critical roles in biological processes and lipids biomarkers can substitute
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Identification of Neutrophil Extracellular Trap-Related Gene Expression Signatures in Ischemia Reperfusion Injury During Lung Transplantation: A Transcriptome Analysis and Clinical Validation J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-12 Jiameng Gao, Zhiyuan Zhang, Jing Yu, Nan Zhang, Yu Fu, Xuemei Jiang, Zheyu Xia, Qingqing Zhang, Zongmei Wen
Purpose: Ischemia reperfusion injury (IRI) unavoidably occurs during lung transplantation, further contributing to primary graft dysfunction (PGD). Neutrophils are the end effectors of IRI and activated neutrophils release neutrophil extracellular traps (NETs) to further amplify damage. Nevertheless, potential contributions of NETs in IRI remain incompletely understood. This study aimed to explore
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Bioinformatics and Integrative Experimental Method to Identifying and Validating Co-Expressed Ferroptosis-Related Genes in OA Articular Cartilage and Synovium J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-12 Jinxin Ma, Peng Yu, Shang Ma, Jinjin Li, Zhen Wang, Kunpeng Hu, Xinzhe Su, Bei Zhang, Shao Cheng, Shangzeng Wang
Purpose: Osteoarthritis (OA) is the most common joint disease worldwide and is the primary cause of disability and chronic pain in older adults.Ferroptosis is a type of programmed cell death characterized by aberrant iron metabolism and reactive oxygen species accumulation; however, its role in OA is not known. Methods: To identify ferroptosis markers co-expressed in articular cartilage and synovium
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Advanced Progress of Histone Deacetylases in Rheumatic Diseases J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-12 Xue-Mei Liu, Liu Yang, Qi-Bin Yang
Abstract: Rheumatic disease is a disease which is not yet fully clarified to etiology and also involved in a local pathological injury or systemic disease. With the continuous improvement of clinical medical research in recent years, the development process of rheumatic diseases has been gradually elucidated; with the intensely study of epigenetics, it is realized that environmental changes can affect
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Hydrogen Regulates Ulcerative Colitis by Affecting the Intestinal Redox Environment J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-12 Jiayi Li, Gang Huang, Juexin Wang, Sui Wang, Yanbo Yu
Abstract: The redox balance in the intestine plays an important role in maintaining intestinal homeostasis, and it is closely related to the intestinal mucosal barrier, intestinal inflammation, and the gut microbiota. Current research on the treatment of ulcerative colitis has focused on immune disorders, excessive inflammation, and oxidative stress. However, an imbalance in intestinal redox reaction
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C-Reactive Protein-Albumin Ratio (CAR): A More Promising Inflammation-Based Prognostic Marker for Patients Undergoing Curative Hepatectomy for Hepatocellular Carcinoma J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-12 Rong-Yun Mai, Ting-Li Lu, Ri-Jin Lu, Can Zeng, Fang Lian, Le-Qun Li, Guo-Bin Wu, Jia-Zhou Ye
Background: Systemic inflammatory response is a hallmark of cancer and plays a significant role in the development and progression of various malignant tumors. This research aimed to estimate the prognostic function of the C-reactive protein-albumin ratio (CAR) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC) and compare it with other inflammation-based prognostic scores, including
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Serum Albumin Level Can Predict Immunotherapy Response of Neuromyelitis Optica Spectrum Disorders in the Acute Phase J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-12 Weiwei Xiang, Yifan Wu, Hongyan Li, Desheng Zhu, Xiaoying Yao, Jie Ding, Ze Wang, Yangtai Guan
Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disease of the central nervous system. However, few biomarkers have been found to predict the outcome of immunotherapy. We investigated the relationship between the serum albumin (S-Alb) and response to immunotherapy in acute NMOSD patients. Methods: A total of 107 consecutive Chinese patients with acute NMOSD
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The Use of the Neoglycolipid-Based Oligosaccharide Microarray System in the Diagnosis of Endometriosis – Preliminary Study J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-09 Cezary Wojtyla, Ignacy Tołwiński, Piotr Laudański
Objective: Endometriosis presents diagnostic challenges, and there is a need for developing novel biomarkers with satisfactory specificity and sensitivity. Glycomics, exploring glycosylation changes in glycoproteins, offers potential solutions. The aim of this study was to analyze the carbohydrate-binding properties of IgG and IgM antibodies in the plasma and peritoneal fluid samples and to identify
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The Effect of Osthole on Transient Receptor Potential Channels: A Possible Alternative Therapy for Atopic Dermatitis J. Inflammation Res. (IF 4.5) Pub Date : 2024-02-09 Natalia Karolina Kordulewska, Angelika Król-Grzymała
Introduction: Chronic recurrent skin inflammation and severe itching in patients with atopic dermatitis (AD) significantly impair their quality of life. The H4 histamine receptor plays a key role in histamine-induced itching. During the skin inflammation associated with AD, pro-inflammatory mediators (interleukins, cytokines) are released from neurons. Ultimately, a cascade of reactions leads to the