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Ginseng-derived compounds as potential anticancer agents targeting cancer stem cells J. Ginseng Res. (IF 6.3) Pub Date : 2024-03-12 Ji-Sun Lee, Ho-Young Lee
Cancer stem cells (CSCs) are a rare subpopulation of cancer cells that exhibit stem cell-like characteristics, including self-renewal and differentiation in a multi-stage lineage state via symmetric or asymmetric division, causing tumor initiation, heterogeneity, progression, and recurrence and posing a major challenge to current anticancer therapy. Despite the importance of CSCs in carcinogenesis
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Ginsenoside Rg1 alleviates vascular remodeling in hypoxia-induced pulmonary hypertension mice through the calpain-1/STAT3 signaling pathway J. Ginseng Res. (IF 6.3) Pub Date : 2024-03-11 Chenyang Ran, Meili Lu, Fang Zhao, Yi Hao, Xinyu Guo, Yunhan Li, Yuhong Su, Hongxin Wang
Hypoxic pulmonary hypertension (HPH) is the main pathological change in vascular remodeling, a complex cardiopulmonary disease caused by hypoxia. Some research results have shown that ginsenoside Rg1 (Rg1) can improve vascular remodeling, but the effect and mechanism of Rg1 on hypoxia-induced pulmonary hypertension are not clear. The purpose of this study was to discuss the potential mechanism of action
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Metabolism and drug interactions of Korean ginseng based on the pharmacokinetic properties of ginsenosides: Current status and future perspectives J. Ginseng Res. (IF 6.3) Pub Date : 2024-03-04 Jong Dae Park
Orally administered ginsenosides, the major active components of ginseng, have been shown to be biotransformed into a number of metabolites by gastric juice, digestive and bacterial enzymes in the gastrointestinal tract and also in the liver. Attention is brought to pharmacokinetic studies of ginseng that need further clarification to better understand the safety and possible active mechanism for clinical
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Integration of virtual screening and proteomics reveals potential targets and pathways for ginsenoside Rg1 against myocardial ischemia J. Ginseng Res. (IF 6.3) Pub Date : 2024-02-22 Rongfang Xie, Chenlu Li, Chenhui Zhong, Zuan Lin, Shaoguang Li, Bing Chen, Youjia Wu, Fen Hu, Peiying Shi, Hong Yao
Ginsenoside Rg (Rg) is one of the main active components in Chinese medicines, and . Research has shown that Rg has a protective effect on the cardiovascular system, including anti-myocardial ischemia-reperfusion injury, anti-apoptosis, and promotion of myocardial angiogenesis, suggesting it a potential cardiovascular agent. However, the protective mechanism involved is still not fully understood.
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Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia J. Ginseng Res. (IF 6.3) Pub Date : 2024-02-17 Rami Lee, Ji-Hun Kim, Won-Woo Kim, Sung-Hee Hwang, Sun-Hye Choi, Jong-Hoon Kim, Ik-Hyun Cho, Manho Kim, Seung-Yeol Nah
Ginseng is a traditional herbal medicine used for prevention and treatment of various diseases as a tonic. Recent scientific cohort studies on life prolongation with ginseng consumption support this record, as those who consumed ginseng for more than 5 years had reduced mortality and cognitive decline compared to those who did not. Clinical studies have also shown that acute or long-term intake of
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Methanol-involved heterogeneous transformation of ginsenoside Rb1 to rare ginsenosides using heteropolyacids embedded in mesoporous silica with HPLC-MS investigation J. Ginseng Res. (IF 6.3) Pub Date : 2024-02-08 Mengya Zhao, Yusheng Xiao, Yanyan Chang, Lu Tian, Yujiang Zhou, Shuying Liu, Huanxi Zhao, Yang Xiu
The biological activity and pharmacological effects of rare ginsenosides have been proven to be superior to those of the major ginsenosides, but they are rarely found in ginseng. Ginsenoside Rb1 was chemically transformed with the involvement of methanol molecules by a synthesized heterogeneous catalyst 12-HPW@MeSi, which was obtained by the immobilization of 12-phosphotungstic acid on a mesoporous
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Ginsenoside Rg5, a potent agonist of Nrf2, inhibits HSV-1 infection-induced neuroinflammation by inhibiting oxidative stress and NF-κB activation J. Ginseng Res. (IF 6.3) Pub Date : 2024-02-06 Buyun Kim, Young Soo Kim, Wei Li, Eun-Bin Kwon, Hwan-Suck Chung, Younghoon Go, Jang-Gi Choi
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Systematic exploration of therapeutic effects and key mechanisms of Panax ginseng using network-based approaches J. Ginseng Res. (IF 6.3) Pub Date : 2024-01-24 Young Woo Kim, Seon-Been Bak, Yu Rim Song, Chang-Eop Kim, Won-Yung Lee
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Assessing systemic, developmental, and reproductive toxicity and estrogenicity of Korean red ginseng extract G1899 in juvenile Sprague-Dawley Rats J. Ginseng Res. (IF 6.3) Pub Date : 2024-01-21 Sangyun Kim, Ji-Seong Jeong, Woojin Kim, Onju Ham, Yixian Quah, Soontag Jung, Dong-Ju Park, Min Jae Kim, Byung-Cheol Han, Eunji Kim, Seung-Jin Lee, Wook-Joon Yu
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Mass spectrometry-based ginsenoside profiling: Recent applications, limitations, and perspectives J. Ginseng Res. (IF 6.3) Pub Date : 2024-01-19 Hyun Woo Kim, Dae Hyun Kim, Byeol Ryu, You Jin Chung, Kyungha Lee, Young Chang Kim, Jung Woo Lee, Dong Hwi Kim, Woojong Jang, Woohyeon Cho, Hyeonah Shim, Sang Hyun Sung, Tae-Jin Yang, Kyo Bin Kang
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Combination of red ginseng and velvet antler extracts prevents skin damage by enhancing the antioxidant defense system and inhibiting MAPK/AP-1/NF-κB and caspase signaling pathways in UVB-irradiated HaCaT keratinocytes and SKH-1 hairless mice J. Ginseng Res. (IF 6.3) Pub Date : 2024-01-17 Van-Long Truong, Yeon-Ji Bae, Ji-Hong Bang, Woo-Sik Jeong
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Ginseng root-derived exosome-like nanoparticles protect skin from UV irradiation and oxidative stress by suppressing activator protein-1 signaling and limiting the generation of reactive oxygen species J. Ginseng Res. (IF 6.3) Pub Date : 2024-01-14 Wooram Choi, Jeong Hun Cho, Sang Hee Park, Dong Seon Kim, Hwa Pyoung Lee, Donghyun Kim, Hyun Soo Kim, JI Hye Kim, Jae Youl Cho
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Investigation of the whitening activity of ginsenosides from Panax notoginseng and optimization of the dosage form J. Ginseng Res. (IF 6.3) Pub Date : 2024-01-07 Zeyu Wang, Daiyan Zhang, Mingju Shui, Ian Wa Ho, Weng Si Kou, Jianwen Wei, Jian-Bo Wan, Ruibing Wang, Qing-Wen Zhang
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Sustainable production of natural products using synthetic biology: Ginsenosides J. Ginseng Res. (IF 6.3) Pub Date : 2024-01-03 So-Hee Son, Jin Kang, YuJin Shin, ChaeYoung Lee, Bong Hyun Sung, Ju Young Lee, Wonsik Lee
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Dexamethasone-induced muscle atrophy and bone loss in six genetically diverse collaborative cross founder strains demonstrates phenotypic variability by Rg3 treatment J. Ginseng Res. (IF 6.3) Pub Date : 2023-12-30 Bao Ngoc Nguyen, Soyeon Hong, Sowoon Choi, Choong-Gu Lee, GyHye Yoo, Myungsuk Kim
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20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3 J. Ginseng Res. (IF 6.3) Pub Date : 2023-12-27 Siyu Cheng, Langqun Chen, Jiahui Ying, Ying Wang, Wenjuan Jiang, Qi Zhang, Hong Zhang, Jiahe Wang, Chen Wang, Huimin Wu, Liang Zhang, Jing Ye
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Foeniculum vulgare essential oil nanoemulsion inhibits Fusarium oxysporum causing Panax notoginseng root-rot disease J. Ginseng Res. (IF 6.3) Pub Date : 2023-12-20 Hongyan Nie, Hongxin Liao, Jinrui Wen, Cuiqiong Ling, Liyan Zhang, Furong Xu, Xian Dong
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Gintonin upregulates cytokine production and expression of NKp30, NKp44 and NKp44 related to natural killer cell activity on immunosuppressive rat J. Ginseng Res. (IF 6.3) Pub Date : 2023-12-12 BaiCheng Chen, Ajay Vijayakumar, Chul Park, Ulsoo Choi, Seung-Yeol Nah, Jong-Hoon Kim
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Ginseng-derived type I rhamnogalacturonan polysaccharide binds to galectin-8 and antagonizes its function J. Ginseng Res. (IF 6.3) Pub Date : 2023-12-06 Yi Zheng, Yunlong Si, Xuejiao Xu, Hongming Gu, Zhen He, Zihan Zhao, Zhangkai Feng, Jiyong Su, Kevin H. Mayo, Yifa Zhou, Guihua Tai
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P-hydroxybenzoic acid positively affect the Fusarium oxysporum to stimulate root rot in Panax notoginseng J. Ginseng Res. (IF 6.3) Pub Date : 2023-12-06 Zhao Jing, Wang Zhandi, Jiao Rong, Wan Qionglian, Wang Lianchun, Li Liangxing, Yang Yali, Shahzad Munir
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Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner J. Ginseng Res. (IF 6.3) Pub Date : 2023-12-03 Ziyu Song, Meng Jin, Shenglong Wang, Yanzuo Wu, Qi Huang, Wangda Xu, Yongsheng Fan, Fengyuan Tian
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The pharmacological role of Ginsenoside Rg3 in liver diseases: A review on molecular mechanisms J. Ginseng Res. (IF 6.3) Pub Date : 2023-11-15 Wenhong Wang, Ke Li, Weihua Xiao
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Pharmacological potential of ginseng and ginsenosides in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis J. Ginseng Res. (IF 6.3) Pub Date : 2023-11-14 Young-Su Yi
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Cytokinin signaling promotes root secondary growth and bud formation in Panax ginseng J. Ginseng Res. (IF 6.3) Pub Date : 2023-11-10 Kyoung Rok Geem, Yookyung Lim, Jeongeui Hong, Wonsil Bae, Jinsu Lee, Soeun Han, Jinsu Gil, Hyunwoo Cho, Hojin Ryu
Background Panax ginseng, one of the valuable perennial medicinal plants, stores numerous pharmacological substrates in its storage roots. Given its perennial growth habit, organ regeneration occurs each year, and cambium stem cell activity is necessary for secondary growth and storage root formation. Cytokinin (CK) is a phytohormone involved in the maintenance of meristematic cells for the development
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Korean Red Ginseng suppresses emphysematous lesions induced by cigarette smoke condensate through inhibition of macrophage-driven apoptosis pathways J. Ginseng Res. (IF 6.3) Pub Date : 2023-11-07 Jeong-Won Kim, Jin-Hwa Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Won Ko, Tae-Won Kim
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Ginseng and ginsenosides on cardiovascular and pulmonary diseases; Pharmacological potentials for the coronavirus (COVID-19) J. Ginseng Res. (IF 6.3) Pub Date : 2023-11-02 Ajay Vijayakumar, Jong-Hoon Kim
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Ginsenoside F2 Restrains Hepatic Steatosis and Inflammation by Altering the Binding Affinity of Liver X Receptor Coregulators J. Ginseng Res. (IF 6.3) Pub Date : 2023-10-27 Kyurae Kim, Myung-Ho Kim, Ji In Kang, Jong-In Baek, Byeong-Min Jeon, Ho Min Kim, Sun-Chang Kim, Won-Il Jeong
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Age-induced Changes in Ginsenoside Accumulation and Primary Metabolic Characteristics of Panax Ginseng in Transplantation Mode J. Ginseng Res. (IF 6.3) Pub Date : 2023-10-02 Wei Yuan, Qing-feng Wang, Wen-han Pei, Si-yu Li, Tian-min Wang, Hui-peng Song, Dan Teng, Ting-guo Kang, Hui Zhang
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Inhalation of panaxadiol alleviates lung inflammation via inhibiting TNFA/TNFAR and IL7/IL7R signaling between macrophages and epithelial cells J. Ginseng Res. (IF 6.3) Pub Date : 2023-09-23 Yifan Wang, Hao Wei, Zhen Song, Liqun Jiang, Mi Zhang, Xiao Lu, Wei Li, Yuqing Zhao, Lei Wu, Shuxian Li, Huijuan Shen, Qiang Shu, Yicheng Xie
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Effects of Korean red ginseng on T-cell repopulation after autologous hematopoietic stem cell transplantation in childhood cancer patients J. Ginseng Res. (IF 6.3) Pub Date : 2023-09-09 Kyung Taek Hong, Yeon Jun Kang, Jung Yoon Choi, Young Ju Yun, Il-Moo Chang, Hee Young Shin, Hyoung Jin Kang, Won-Woo Lee
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Botrytis cinerea hypovirulent strain △BcSpd1 induced Panax ginseng defense J. Ginseng Res. (IF 6.3) Pub Date : 2023-09-01 Shuhan Zhang, Junyou Han, Ning Liu, Jingyuan Sun, Huchen Chen, Jinglin Xia, Huiyan Ju, Shouan Liu
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Letter to Editor: Antiviral activities of ginseng and its potential benefit against monkeypox virus: A mini review J. Ginseng Res. (IF 6.3) Pub Date : 2023-09-01 Zubair Ahmed Ratan, Rajib Chandra Das, Jae Youl Cho
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Effects of Red ginseng on neuroinflammation in neurodegenerative diseases J. Ginseng Res. (IF 6.3) Pub Date : 2023-08-29 Min Yeong Lee, Mikyung Kim
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Panaxcerol D from Panax ginseng ameliorates the memory impairment induced by cholinergic blockade or Aβ25–35 peptide in mice J. Ginseng Res. (IF 6.3) Pub Date : 2023-08-18 Keontae Park, Ranhee Kim, Kyungnam Cho, Chang Hyeon Kong, Mijin Jeon, Woo Chang Kang, Seo Yun Jung, Dae Sik Jang, Jong Hoon Ryu
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The effects of Korean Red Ginseng on stress-related neurotransmitters and gene expression: A randomized, double-blind, placebo-controlled trial J. Ginseng Res. (IF 6.3) Pub Date : 2023-08-12 Jihyun Yoon, Byoungjin Park, Kyung-Won Hong, Dong-Hyuk Jung
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The purified extract of steamed Panax ginseng protects cardiomyocyte from ischemic injury via caveolin-1 phosphorylation-mediating calcium influx J. Ginseng Res. (IF 6.3) Pub Date : 2023-08-05 Hai-Xia Li, Yan Ma, Yu-Xiao Yan, Xin-Ke Zhai, Meng-Yu Xin, Tian Wang, Dong-Cao Xu, Yu-Tong Song, Chun-Dong Song, Cheng-Xue Pan
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Methods on improvements of the poor oral bioavailability of ginsenosides: Pre-processing, structural modification, drug combination, and micro- or nano- delivery system J. Ginseng Res. (IF 6.3) Pub Date : 2023-07-26 Qi-rui Hu, Huan Hong, Zhi-hong Zhang, Hua Feng, Ting Luo, Jing Li, Ze-yuan Deng, Fang Chen
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Comment on antiviral activities of ginseng and putative benefits against monkeypox virus J. Ginseng Res. (IF 6.3) Pub Date : 2023-07-23 Amnuay Kleebayoon, Viroj Wiwanitkit
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Korean red ginseng suppresses mitochondrial apoptotic pathway in denervation-induced skeletal muscle atrophy J. Ginseng Res. (IF 6.3) Pub Date : 2023-07-05 Ji-Soo Jeong, Jeong-Won Kim, Jin-Hwa Kim, Chang-Yeop Kim, Je-Won Ko, Tae-Won Kim
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Corrigendum to ‘Effect of fermented red ginseng on gut microbiota dysbiosis- or immobilization stress-induced anxiety, depression, and colitis in mice’[Journal of Ginseng Research Volume 47, Issue 2, March 2023, Pages 255-264] J. Ginseng Res. (IF 6.3) Pub Date : 2023-07-04 Yoon-Jung Shin, Dong-Yun Lee, Joo Yun Kim, Keon Heo, Jae-Jung Shim, Jung-Lyoul Lee, Dong-Hyun Kim
Abstract not available
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Ginsenoside 20(S)-Rg3 reduces KIF20A expression and promotes CDC25A proteasomal degradation in epithelial ovarian cancer J. Ginseng Res. (IF 6.3) Pub Date : 2023-07-04 Rong Zhang, Lei Li, Huihui Li, Hansong Bai, Yuping Suo, Ju Cui, Yingmei Wang
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20(S)-ginsenoside Rg3 exerts anti-fibrotic effect after myocardial infarction by alleviation of fibroblasts proliferation and collagen deposition through TGFBR1 signaling pathways J. Ginseng Res. (IF 6.3) Pub Date : 2023-07-03 Honglin Xu, Haifeng Miao, Guanghong Chen, Guoyong Zhang, Yue Hua, Yuting Wu, Tong Xu, Xin Han, Changlei Hu, Mingjie Pang, Leyi Tan, Bin Liu, Yingchun Zhou
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Ginsenoside Rg5 promotes wound healing in diabetes by reducing the negative regulation of SLC7A11 on the efferocytosis of dendritic cells J. Ginseng Res. (IF 6.3) Pub Date : 2023-06-30 Wei Xia, Zongdong Zhu, Song Xiang, Yi Yang
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Ginsenoside Rg5 promotes muscle regeneration via p38MAPK and Akt/mTOR signaling J. Ginseng Res. (IF 6.3) Pub Date : 2023-06-24 Ryuni Kim, Jee Won Kim, Hyerim Choi, Ji-Eun Oh, Tae Hyun Kim, Ga-Yeon Go, Sang-Jin Lee, Gyu-Un Bae
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Therapeutic applications of ginseng for skeletal muscle-related disorder management J. Ginseng Res. (IF 6.3) Pub Date : 2023-06-22 Syed Sayeed Ahmad, Hee Jin Chun, Khurshid Ahmad, Inho Choi
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Cognitive function improvement effects of gintonin-enriched fraction in subjective memory impairment: An assessor- and participant-blinded placebo-controlled study J. Ginseng Res. (IF 6.3) Pub Date : 2023-06-16 Rami Lee, Han Sang Lee, Won-Woo Kim, Manho Kim, Seung-Yeol Nah
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Corrigendum to’ Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K’ [Journal of Ginseng Research Volume 40, Issue 4, October 2016, Pages 445-452] J. Ginseng Res. (IF 6.3) Pub Date : 2023-06-14 Taddesse Yayeh, Kyunghwa Yun, Soyong Jang, Seikwan Oh
Abstract not available
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Rg3-enriched red ginseng extracts enhance apoptosis in CoCl2-stimulated breast cancer cells by suppressing autophagy J. Ginseng Res. (IF 6.3) Pub Date : 2023-06-07 Yun-Jeong Jeong, Mi-Hee Yu, Yuna Cho, Min-Young Jo, Kwon-Ho Song, Yung Hyun Choi, Taeg Kyu Kwon, Jong-Young Kwak, Young-Chae Chang
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Phenolic acids in Panax ginseng inhibit melanin production through bidirectional regulation of melanin synthase transcription via different signaling pathways J. Ginseng Res. (IF 6.3) Pub Date : 2023-05-28 Jianzeng Liu, Xiaohao Xu, Jingyuan Zhou, Guang Sun, Zhenzhuo Li, Lu Zhai, Jing Wang, Rui Ma, Daqing Zhao, Rui Jiang, Liwei Sun
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Korean Red Ginseng extract ameliorates demyelination by inhibiting infiltration and activation of immune cells in cuprizone-administrated mice J. Ginseng Res. (IF 6.3) Pub Date : 2023-05-15 Min Jung Lee, Jong Hee Choi, Tae Woo Kwon, Hyo-Sung Jo, Yujeong Ha, Seung-Yeol Nah, Ik-Hyun Cho
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Effect of anti-skin disorders of ginsenosides- A Systematic Review J. Ginseng Res. (IF 6.3) Pub Date : 2023-05-04 Lele Cong, Jinli Ma, Yundong Zhang, Yifa Zhou, Xianling Cong, Miao Hao
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Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: Implications for the treatment of cognitive dysfunction J. Ginseng Res. (IF 6.3) Pub Date : 2023-04-29 Feiyan Chen, Wenjing Zhang, Shuyi Xu, Hantao Zhang, Lin Chen, Cuihua Chen, Zhu Zhu, Yunan Zhao
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Anti-thrombotic effects of ginsenoside Rk3 by regulating cAMP and PI3K/MAPK pathway on human platelets J. Ginseng Res. (IF 6.3) Pub Date : 2023-04-22 Hyuk-Woo Kwon, Jung-Hae Shin, Man Hee Rhee, Chang-Eun Park, Dong-Ha Lee
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Skin wound healing effects of (+)-syringaresinol from ginseng berry J. Ginseng Res. (IF 6.3) Pub Date : 2023-04-14 Jee-hyun Hwang, Yeonsoo Kang, Heui-Jin Park, Seolyeong Kim, Su-Hyun Lee, Hangun Kim, Sang-Jip Nam, Kyung-Min Lim
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The anti-platelet activity of panaxadiol fraction and panaxatriol fraction of Korean Red Ginseng in vitro and ex vivo J. Ginseng Res. (IF 6.3) Pub Date : 2023-04-14 Yuan Yee Lee, Yein Oh, Min-Soo Seo, Min-Goo Seo, Jee Eun Han, Kyoo-Tae Kim, Jin-Kyu Park, Sung Dae Kim, Sang-Joon Park, Dongmi Kwak, Man Hee Rhee
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Ginsenoside Rk1 inhibits HeLa cell proliferation through an endoplasmic reticulum signaling pathway J. Ginseng Res. (IF 6.3) Pub Date : 2023-04-14 Qiuyang Li, Hang Sun, Shiwei Liu, Jinxin Tang, Shengnan Liu, Pei Yin, Qianwen Mi, Jingsheng Liu, Lei yu, Yunfeng Bi
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The potential of Panax notoginseng against COVID-19 infection J. Ginseng Res. (IF 6.3) Pub Date : 2023-04-08 Yeye Hu, Ziliang He, Wei Zhang, Zhiqiang Niu, Yanting Wang, Ji Zhang, Ting Shen, Hong Cheng, Weicheng Hu
The COVID-19 pandemic has changed the world and has presented the scientific community with unprecedented challenges. Infection is associated with overproduction of proinflammatory cytokines secondary to hyperactivation of the innate immune response, inducing a cytokine storm and triggering multiorgan failure and significant morbidity/mortality. No specific treatment is yet available. For thousands
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The effects of Korean Red Ginseng on heme oxygenase-1 with a focus on mitochondrial function in pathophysiologic conditions J. Ginseng Res. (IF 6.3) Pub Date : 2023-04-08 Chang-Hee Kim, Hahn Young Kim, Seung-Yeol Nah, Yoon Kyung Choi