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Therapeutic potential of natural flavonoids in pulmonary arterial hypertension: A review Phytomedicine (IF 7.9) Pub Date : 2024-03-12 Jin-jing Zhang, Mao-mao, Min-min Shao, Meng-chuan Wang
Pulmonary arterial hypertension (PAH) is a fatal disease caused by pulmonary vascular remodeling, with a high incidence and mortality. At present, many clinical drugs for treating PAH mainly exert effects by relaxing the pulmonary artery, with limited therapeutic effects, so the search for viable therapeutic agents continues uninterrupted. In recent years, natural flavonoids have shown promising potential
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Lancao decoction alleviates cognitive dysfunction: a new therapeutic drug and its therapeutic mechanism Phytomedicine (IF 7.9) Pub Date : 2024-03-11 Yan Sun, Hailou Zhang, Ruiyi Liu, Rumin Huang, Ziwei Gao, Liyuan Tian, Yaping Zhu, Yuxin Liu, Chao Lu, Lei Wu
Cognitive dysfunction (CD) is a neurodegenerative disease characterized primarily by the decline of learning and memory abilities. The physiological and pathological mechanisms of CD are very complex, which is mainly related to normal function of the hippocampus. Lancao decoction (LC) is a Chinese medicine formula, which has been used to treat neurodegenerative disorders. However, the potential of
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Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway through microbiota-gut-brain axis Phytomedicine (IF 7.9) Pub Date : 2024-03-11 Shuxia Zhang, Qiuyan Chen, Meiqi Jin, Jiahui Ren, Xiao Sun, Zhixiu Zhang, Yun Luo, Xiaobo Sun
Ischemic stroke (IS) ranks as the second common cause of death worldwide. However, a narrow thrombolysis timeframe and ischemia-reperfusion (I/R) injury limits patient recovery. Moreover, anticoagulation and antithrombotic drugs do not meet the clinical requirements. Studies have demonstrated close communication between the brain and gut microbiota in IS. Notoginsenoside R1 (NG-R1), a significant component
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Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction Phytomedicine (IF 7.9) Pub Date : 2024-03-11 Ya Hou, Fuhan Fan, Na Xie, Yi Zhang, Xiaobo Wang, Xianli Meng
(Hook. f. et Thoms.) H. Ohba (), a famous and characteristic Tibetan medicine, has been demonstrated to exert an outstanding brain protection role in the treatment of high-altitude hypoxia disease. However, the metabolic effects of on high-altitude hypoxic brain injury (HHBI) are still incompletely understood. Herein, the anti-hypoxic effect and associated mechanisms of were explored through both and
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Mulberry leaf and its effects against obesity: a systematic review of phytochemistry, molecular mechanisms and applications Phytomedicine (IF 7.9) Pub Date : 2024-03-11 Ruilin Li, Jia Wang, Junyu Liu, Mingyue Li, Jingyang Lu, Jingna Zhou, Min Zhang, Nicola Ferri, Haixia Chen
Obesity and hyperlipidemia can induce a variety of diseases, and have become a major health problem worldwide. How to effectively prevent and control obesity has become one of the hot-spots of contemporary research. Mulberry leaf is the dried leaf of L., which is approved by the Ministry of Health as a “homology of medicine and food”, rich in diverse active constituents and with a variety of health
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Moracin D suppresses cell growth and induces apoptosis via targeting the XIAP/PARP1 axis in pancreatic cancer Phytomedicine (IF 7.9) Pub Date : 2024-03-11 Xi Zhong, Xiaoxue Ke, He Yang, Xiang Ye, Can Li, Jun Pan, Wenhao Ran, Feng Wang, Hongjuan Cui
Oncogenic protein XIAP interacted with PARP1 and stabilized it by regulating its ubiquitination, thus facilitating the malignant progression of pancreatic cancer. Moracin D extracted from L. could decrease the protein stability and expression of XIAP through the ubiquitin-proteasome pathway and block the XIAP/PARP1 axis, which suggested that Moracin D repress cell growth and tumorigenesis, induce cell
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Morus alba L. (Sangzhi) alkaloids mitigate atherosclerosis by regulating M1/M2 macrophage polarization Phytomedicine (IF 7.9) Pub Date : 2024-03-11 Dandan Peng, Fen Zhuge, Mingwei Wang, Binbin Zhang, Zhenjie Zhuang, Run Zhou, Yuanyuan Zhang, Zhenqiu Yu, Junping Shi
Atherosclerosis (AS) is an important cause of cardiovascular disease, posing a substantial health risk. Recognized as a chronic inflammatory disorder, AS hinges on the pivotal involvement of macrophages in arterial inflammation, participating in its formation and progression. Sangzhi alkaloid (SZ-A) is a novel natural alkaloid extracted from the mulberry branches, has extensive pharmacological effects
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Co-decoction of Lilii bulbus and Radix Rehmannia Recens and its key bioactive ingredient verbascoside inhibit neuroinflammation and intestinal permeability associated with chronic stress-induced depression via the gut microbiota-brain axis Phytomedicine (IF 7.9) Pub Date : 2024-03-11 Qiancheng Mao, Hongxiu Zhang, Zhe Zhang, Yanting Lu, Jin Pan, Dongjing Guo, Liuxuan Huang, Haoquan Tian, Ke Ma
Gut microbiota plays a critical role in the pathogenesis of depression and are a therapeutic target via maintaining the homeostasis of the host through the gut microbiota–brain axis (GMBA). A co-decoction of Lilii bulbus and (LBRD), in which verbascoside is the key active ingredient, improves brain and gastrointestinal function in patients with depression. However, in depression treatment using verbascoside
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The antitumor effects of herbal medicine Triphala on oral cancer by inactivating PI3K/Akt signaling pathway: based on the network pharmacology, molecular docking, in vitro and in vivo experimental validation Phytomedicine (IF 7.9) Pub Date : 2024-03-11 Shaonan Hu, Simin Li, Yuzhen Xu, Xiuhong Huang, Zhaoyi Mai, Yuanxin Chen, Hui Xiao, Wanchen Ning, Sebastian Gaus, Vuk Savkovic, Bernd Lethaus, Rüdiger Zimmerer, Aneesha Acharya, Dirk Ziebolz, Gerhard Schmalz, Shaohong Huang, Jianjiang Zhao, Xianda Hu
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Lycorine inhibits Ang II-induced heart remodeling and inflammation by suppressing the PI3K-AKT/NF-κB pathway Phytomedicine (IF 7.9) Pub Date : 2024-03-11 Pingping Tuo, Risheng Zhao, Ning Li, Shuang Yan, Gege Yang, Chunmei Wang, Jinghui Sun, Haiming Sun, Mengyang Wang
Ang II induces hypertensive heart failure (HF) via hemodynamic and non-hemodynamic actions. Lycorine (LYC) is an alkaloid derived from Lycoris bulbs, and it possesses anti-cardiovascular disease-related activities. Herein, we explored the potential LYC-mediated regulation of Ang II-induced HF. Over 4 weeks, we established a hypertensive HF mouse model by infusing Ang II into C57BL/6 mice using a micro-osmotic
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Jaceosidin attenuates the progression of hepatic fibrosis by inhibiting the VGLL3/HMGB1/TLR4 signaling pathway Phytomedicine (IF 7.9) Pub Date : 2024-03-10 Youli Yao, Xiaoling Zuo, Feng Shao, Kenxin Yu, Quanquan Liang
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MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR−/− mice Phytomedicine (IF 7.9) Pub Date : 2024-03-10 Jia Shi, Mingming Yang, Shu Yang, Fangyang Fan, Guobin Zheng, Yaodong Miao, Yunqing Hua, Jing Zhang, Yanfei Cheng, Shangjing Liu, Yuying Guo, Liping Guo, Xiaoxiao Yang, Guanwei Fan, Chuanrui Ma
Atherosclerosis is the primary pathological basis of cardiovascular disease. Ferroptosis is a regulated form of cell death, a process of lipid peroxidation driven by iron, which can initiate and promote atherosclerosis. STAT6 is a signal transducer that shows a potential role in regulating ferroptosis, but, the exact role in ferroptosis during atherogenesis remains unclear. The traditional Chinese
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Potential effects and mechanism of flavonoids extract of Callicarpa nudiflora Hook on DSS-induced colitis in mice Phytomedicine (IF 7.9) Pub Date : 2024-03-09 Keyi Nong, Xinyun Qin, Zhineng Liu, Zihan Wang, Yijia Wu, Bin Zhang, Wanyan Chen, Xin Fang, Youming Liu, Xuemei Wang, Haiwen Zhang
Hook () is an anti-inflammatory, antimicrobial, antioxidant, and hemostatic ethnomedicine. To date, little has been reported regarding the activity of C. nudiflora against ulcerative colitis (UC). In this study, we investigated the effect of a flavonoid extract of on Dextran Sulfate Sodium (DSS)-induced ulcerative colitis in mice. Mice in the treatment group (DSS+CNLF group) and drug-only (CNLF group)
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Therapeutic efficacy and anti-inflammatory mechanism of baicalein on endometriosis progression in patient-derived cell line and mouse model Phytomedicine (IF 7.9) Pub Date : 2024-03-09 Wonhyoung Park, Hyewon Jang, Hee Seung Kim, Soo Jin Park, Whasun Lim, Gwonhwa Song, Sunwoo Park
Baicalein is a flavonoid extracted from the roots of G. that has anti-inflammatory and antitumor effects. However, therapeutic mechanisms of baicalein in patients with endometriosis have yet to be elucidated. As a chronic inflammatory gynecological disease, endometriosis causes pain and infertility, and has no complete treatment to date. Current treatment strategies cause several side effects and have
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Salvia miltiorrhiza Bunge (Danshen) based nano delivery systems for anticancer therapeutics Phytomedicine (IF 7.9) Pub Date : 2024-03-08 Yiyang Jia, Dandan Yao, Hui Bi, Jing Duan, Wei Liang, Ziwei Jing, Mei Liu
The ancient Chinese herb (Danshen), plays the important role in cardiovascular and cerebrovascular disease. Furthermore, Danshen could also be used for curing carcinogenesis. Up to now, the anti-tumor effects of the main active constituents of Danshen have made great progress. However, the bioavailability of the active constituents of Danshen were restricted by their unique physical characteristics
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Americanin B inhibits pyroptosis in lipopolysaccharide-induced septic encephalopathy mice through targeting NLRP3 protein Phytomedicine (IF 7.9) Pub Date : 2024-03-08 Yeshu Liu, Xiaohu Yao, Yanqiu Yang, Yan Mi, Yingjie Wang, Shaowen Tan, Mingxia Fang, Qingqi Meng, Gang Chen, Ning Li, Yue Hou
Sepsis is considered as a severe illness due to its high mortality. Sepsis can cause septic encephalopathy, thus leading to brain injury, behavioral and cognitive dysfunction. Pyroptosis is a type of regulated cell death (RCD) and takes a crucial part in occurrence and development of sepsis. Americanin B (AMEB) is a lignan compounds, which is extracted from . In our previous study, AMEB could inhibit
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Total paeony glycoside relieves neuroinflammation to exert antidepressant effect via the interplay between NLRP3 inflammasome, pyroptosis and autophagy Phytomedicine (IF 7.9) Pub Date : 2024-03-08 Lili Su, Haoyu Lu, Dongxue Zhang, Xaioying Zhu, Jianming Li, Ying Zong, Yan Zhao, Zhongmei He, Weijia Chen, Rui Du
Depression is a common mental illness characterised by abnormal and depressed emotions. Total paeony glycoside (TPG) is a naturally active saponin extracted from the traditional Chinese medicine Radix Paeoniae Rubra. However, the antidepressant and neuroinflammatory effects of TPG have not been thoroughly studied. To study the therapeutic potential of TGP in depression caused by neuronal injury and
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Effect of Pulsatilla decoction on vulvovaginal candidiasis in mice. Evidences for its mechanisms of action Phytomedicine (IF 7.9) Pub Date : 2024-03-08 Kaifan Hu, Xiaojuan Jiang, Jiaping Zhang, Dan Xia, Daqiang Wu, Jing Shao, Tianming Wang, Changzhong Wang
Vulvovaginal candidiasis (VVC) is a common infection that affects the female reproductive tract. decoction (PD), a traditional Chinese herbal medicine, is a classic and effective prescription for VVC. However, its mechanism of action remains unclear. This study aimed to evaluate the efficacy and potential mechanism of action of the n-butanol extract of decoction (BEPD) in VVC treatment. High performance
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Berberine promotes the degradation of phenylacetic acid to prevent thrombosis by modulating gut microbiota Phytomedicine (IF 7.9) Pub Date : 2024-03-07 Hao-Jian Zhang, Jie Fu, Hang Yu, Hui Xu, Jia-Chun Hu, Jin-Yue Lu, Meng-Meng Bu, Zhao Zhai, Jing-Yue Wang, Meng-Liang Ye, Heng-Tong Zuo, Jian-Ye Song, Yi Zhao, Jian-Dong Jiang, Yan Wang
Berberine is the main bioactive constituent of yellow lotus, a quaternary ammonium alkaloid. While berberine's cardiovascular benefits are well-documented, its impact on thrombosis remains not fully understood. This study investigates the potential of intestinal microbiota as a novel target for preventing thrombosis, with a focus on berberine, a natural compound known for its effectiveness in managing
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Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction Phytomedicine (IF 7.9) Pub Date : 2024-03-07 Wei Shi, Guang Xu, Yuan Gao, Huijie Yang, Tingting Liu, Jia Zhao, Hui Li, Ziying Wei, Xiaorong Hou, Yuanyuan Chen, Jincai Wen, Chengwei Li, Jun Zhao, Ping Zhang, Zhongxia Wang, Xiaohe Xiao, Zhaofang Bai
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon (IFN) genes (STING) pathway is critical in the innate immune system and can be mobilized by cytosolic DNA. The various inflammatory and autoimmune diseases progression is highly correlated with aberrant cGAS-STING pathway activation. While some cGAS-STING pathway inhibitor were identified, there are no drugs that can be applied to the clinic
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Natural Autophagy Activators: A Promising Strategy for Combating Photoaging Phytomedicine (IF 7.9) Pub Date : 2024-03-04 Apeksha Vikram, Sunil Kumar Patel, Arshwinder Singh, Diksha Pathania, Ratan Singh Ray, Atul Kumar Upadhyay, Ashish Dwivedi
Photodamage to the skin stands out as one of the most widespread epidermal challenges globally. Prolonged exposure to sunlight containing ultraviolet radiation (UVR) instigates stress, thereby compromising the skin's functionality and culminating in photoaging. Recent investigations have shed light on the importance of autophagy in shielding the skin from photodamage. Despite the acknowledgment of
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Combining cisplatin with Pinellia pedatisecta Schott lipid-soluble extract induces tumor immunogenic cell death in cervical cancer Phytomedicine (IF 7.9) Pub Date : 2024-03-03 Congwen Wang, Mingxing Zhang, Jing Peng, Meng Zhang, Chong Lu, Xingling Qi, Qingyan Luo, Yumeng Wang, Guiling Li
Schott extract (PE) is extracted from Schott (PPS), a traditional Chinese medicinal plant with the potential for direct anticancer effects or eliciting an anti-tumor response by activating the immune system. To explore PE's ability and mechanism to reconstruct cisplatin's immunogenicity. Cervical cancer cells were treated with cisplatin (CDDP) and/or PE. The exposure of calreticulin (CRT) on cell membrane
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Mechanic evaluation of Wu-Mei-Pill on colitis-associated colorectal cancer: An integrated transcriptomics, metabolomics, and experimental validation study Phytomedicine (IF 7.9) Pub Date : 2024-03-02 Huantian Cui, Yutong Jin, Ning Wang, Haizhao Liu, Rongli Shu, Jida Wang, Xiangling Wang, Beitian Jia, Yiyang Wang, Yuhong Bian, Weibo Wen
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Shikonin suppresses rheumatoid arthritis by inducing apoptosis and autophagy via modulation of the AMPK/mTOR/ULK-1 signaling pathway Phytomedicine (IF 7.9) Pub Date : 2024-03-02 Xiao-hua Wang, Chuan-pu Shen, Tian-tian Wang, Yan Huang, Yuan Jin, Meng-yuan Zhou, Man-yu Zhang, Sheng-long Gu, Meng-qing Wang, Zhi-cheng Liu, Rong Li, Li Cai
The overproliferation of fibroblast-like synoviocytes (FLS) contributes to synovial hyperplasia, a pivotal pathological feature of rheumatoid arthritis (RA). Shikonin (SKN), the active compound from , exerts anti-RA effects by diverse means. However, further research is needed to confirm SKN's in vitro and in vivo anti-proliferative functions and reveal the underlying specific molecular mechanisms
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Recent advances in the therapeutic potential of nobiletin against respiratory diseases Phytomedicine (IF 7.9) Pub Date : 2024-03-01 Yanqin Qin, Jingfan Yang, Haibo Li, Jiansheng Li
Nobiletin is a natural polymethoxylated flavonoid widely present in citrus fruit peels. It has been extensively studied due to its wide range of pharmacological activities and considered a potential therapeutic drug for various diseases. It has been demonstrated to exert the effects of anti-tumor, anti-inflammation, anti-oxidative, anti-apoptotic and improve cardiovascular function. Increasing evidences
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Jiangu formula: A novel osteoclast-osteoblast coupling agent for effective osteoporosis treatment Phytomedicine (IF 7.9) Pub Date : 2024-02-28 Huazhen Xu, Xiuli Lu, Mei Li, Xiaodan Huang, Nan Yao, Haining Gan, Xuejun Huang, Ziming Zhao, Zixuan Hu, Xinxin Zhao, Yijing Lai, Minyi Li, Shilong Chen, Yuxing Chen, Dane Huang
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Strictosamide alleviates acute lung injury via regulating T helper 17 cells, regulatory T cells, and gut microbiota Phytomedicine (IF 7.9) Pub Date : 2024-02-28 Yu-Huang Wu, Qiao-Ling Zhang, Shi-Ying Mai, Gu-Xu Ming, Cheng-Feng Zheng, Chang-Fu Liang, Feng-Ming Xue, Xiao-Ning He, Yong-Hui Li
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Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation Phytomedicine (IF 7.9) Pub Date : 2024-02-28 Ziliang He, Yeye Hu, Ying Zhang, Jing Xie, Zhiqiang Niu, Guigui Yang, Ji Zhang, Zixuan Zhao, Shuai Wei, Haifeng Wu, Weicheng Hu
Parkinson's disease (PD), a neurodegenerative disorder, is characterized by motor symptoms due to the progressive loss of dopaminergic neurons in the substantia nigra (SN) and striatum (STR), alongside neuroinflammation. Asiaticoside (AS), a primary active component with anti-inflammatory and neuroprotective properties, is derived from However, the precise mechanisms through which AS influences PD
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Genus Paeonia monoterpene glycosides: A systematic review on their pharmacological activities and molecular mechanisms Phytomedicine (IF 7.9) Pub Date : 2024-02-28 Shi-yi Xu, Hui-yan Cao, Rui-hong Yang, Rong-xue Xu, Xing-yu Zhu, Wei Ma, Xiu-bo Liu, Xue-ying Yan, Peng Fu
Genus which is the main source of Traditional Chinese Medicine (TCM) Paeoniae Radix Rubra (Chishao in Chinese), Paeoniae Radix Alba (Baishao in Chinese) and Moutan Cortex (Mudanpi in Chinese), is also rich in active pharmaceutical ingredient such as monoterpenoid glycosides (MPGs). MPGs from have extensive pharmacological effects, but the pharmacological effects and molecular mechanisms of MPGs has
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Intranasal delivery of herbal medicine for disease treatment: A systematic review Phytomedicine (IF 7.9) Pub Date : 2024-02-28 Khoa Nguyen Tran, Ji-Hye Kwon, Min-Kyung Kim, Nhi Phuc Khanh Nguyen, In-Jun Yang
Intranasal administration has been adopted in traditional medicine to facilitate access to the bloodstream and central nervous system (CNS). In modern medicine, nasal drug delivery systems are valuable for disease treatment because of their noninvasiveness, good absorption, and fast-acting effects. This study aimed to systematically organize preclinical and clinical studies on intranasal herbal medicines
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Astragalus polysaccharides attenuate chemotherapy-induced immune injury by modulating gut microbiota and polyunsaturated fatty acid metabolism Phytomedicine (IF 7.9) Pub Date : 2024-02-28 Hao Wang, Weize Zhu, Ying Hong, Wenjing Wei, Ningning Zheng, Xiaofang He, Yiyang Bao, Xinxin Gao, Wenjin Huang, Lili Sheng, Mingxiao Li, Houkai Li
The damage of chemotherapy drugs to immune function and intestinal mucosa is a common side effect during chemotherapy. Astragalus polysaccharides (APS) exhibit immunomodulatory properties and are recognized for preserving the integrity of the human intestinal barrier. Nevertheless, their application and mechanisms of action in chemotherapy-induced immune damage and intestinal barrier disruption remain
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Ginseng fermentation solution affects the gut microbiota in zebrafish with alcoholic liver disease via PI3K/Akt pathway Phytomedicine (IF 7.9) Pub Date : 2024-02-27 Yongxi Wu, Shuhan Liu, Tao Ren, Liting Ma, Jing Luo, Meiyu Zhang, Fangtong Li, Yulin Dai, Fei Zheng, Zifeng Pi, Hao Yue
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Insights into Q-markers of honey-fried licorice in treating spleen deficiency based on substance and energy metabolism regulation Phytomedicine (IF 7.9) Pub Date : 2024-02-27 Wenxin Xia, Yushu Wang, Jiahui Yue, Xueyan Fu
Honey-fried Licorice (HFL) is a dosage form of Glycyrrhizae Radix et Rhizome processed with honey, which has been recorded to exhibit better efficacy in tonifying the spleen compared to the raw product. In contrast, different processing methods of Glycyrrhizae Radix et Rhizome exhibit different efficacies and applications, but their current quality control index components remain consistent. Based
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Extending the Grading of Recommendations Assessment, Development and Evaluation (GRADE) in Traditional Chinese Medicine (TCM): The GRADE-TCM Phytomedicine (IF 7.9) Pub Date : 2024-02-27 Qin-Wei Fu, Xin-Rong Li, Yang Liu, Shu-Cheng Chen, Wei-Ting Liu, Zhi-Qing Liu, Ying Liu, Yan Xie, Li Fu, Lan-Zhi Zhang, Min Liu, Da-Zheng Zhang, Sha-Sha Yang, Fu-Bin Zhang, He-Yin Huang, Juan Zhong, Kai-Yun Pang, Yong-Na Chen, Ye-Peng Yang, Meng-Lin Dai, Shu-Yun Liu, Shi-Peng Zhang, Feng Xiang, Mi Tang, Pei-Jia Li, Cai- Shan Fang, Qin-Xiu Zhang, Wing-Fai Yeung
To extend and form the “Grading of Recommendations Assessment, Development and Evaluation in Traditional Chinese Medicine” (GRADE-TCM). Methodologies were systematically reviewed and analyzed concerning evidence-based TCM guidelines worldwide. A survey questionnaire was developed based on the literature review and open-end expert interviews. Then, we performed expert consensus, discussion meeting,
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Efficacy and safety of Shenbai Granules for recurrent colorectal adenoma: A multicenter randomized controlled trial Phytomedicine (IF 7.9) Pub Date : 2024-02-27 Mingxin Ni, Ye Zhang, Zhenzhen Sun, Qing Zhou, Jun Xiao, Beiping Zhang, Jiang Lin, Biao Gong, Fengbin Liu, Fandong Meng, Guoyin Zheng, Yan Wang, Limei Gu, Liu Li, Weixing Shen, Yugen Chen, Yanmei Liu, Ling Li, Tingsheng Ling, Haibo Cheng
Colorectal adenoma is benign glandular tumor of colon, the precursor of colorectal cancer. But no pharmaceutical medication is currently available to treat and prevent adenomas. To evaluate efficacy of Shenbai Granules, an herbal medicine formula, in reducing the recurrence of adenomas. This multicenter, randomized, double-blind, placebo-controlled clinical trial was conducted by eight hospitals in
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TCMSSD: A comprehensive database focused on syndrome standardization Phytomedicine (IF 7.9) Pub Date : 2024-02-27 Lin Huang, Qiao Wang, Qingchi Duan, Weiman Shi, Dianming Li, Wu Chen, Xueyan Wang, Hongli Wang, Ming Chen, Haodan Kuang, Yun Zhang, Mingzhi Zheng, Xuanlin Li, Zhixing He, Chengping Wen
Quantitative and standardized research on syndrome differentiation has always been at the forefront of modernizing Traditional Chinese Medicine (TCM) theory. However, the majority of existing databases primarily concentrate on the network pharmacology of herbal prescriptions, and there are limited databases specifically dedicated to TCM syndrome differentiation. In response to this gap, we have developed
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Arctigenin from Arctium lappa L. inhibits chikungunya virus by affecting its entry and replication Phytomedicine (IF 7.9) Pub Date : 2024-02-27 Shridhar Shukla, Mahadeo Kakade, Sarah Cherian, Kalichamy Alagarasu, Deepti Parashar
Dengue and chikungunya, caused by dengue virus (DENV) and chikungunya virus (CHIKV) respectively, are the most common arthropod-borne viral diseases worldwide, for which there are no FDA-approved antivirals or effective vaccines. Arctigenin, a phenylpropanoid lignan from the seeds of L. is known for its anti-inflammatory, anti-cancer, antibacterial, and immunomodulatory properties. Arctigenin's antimicrobial
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Ginseng-derived nanoparticles alleviate alcohol-induced liver injury by activating the Nrf2/HO-1 signalling pathway and inhibiting the NF-κB signalling pathway in vitro and in vivo Phytomedicine (IF 7.9) Pub Date : 2024-02-25 Wenjing Li, Song Yang, Yueming Zhao, Giada Di Nunzio, Limei Ren, Liangliang Fan, Ronghua Zhao, Daqing Zhao, Jiawen Wang
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Smilax china L. polysaccharide prevents HFD induced-NAFLD by regulating hepatic fat metabolism and gut microbiota Phytomedicine (IF 7.9) Pub Date : 2024-02-24 Wenkai Zhang, Longhui Yu, Qinru Yang, Jinfeng Zhang, Wenjing Wang, Xinru Hu, Jingen Li, Guodong Zheng
The increasing incidence of nonalcoholic fatty liver disease(NAFLD) has urged the development of new therapeutics. NAFLD is intimately linked to gut microbiota due to the hepatic portal system, and utilizing natural polysaccharides as prebiotics has become a prospective strategy for preventing NAFLD. Smilax china L. polysaccharide (SCP) possesses excellent hepatoprotective and anti-inflammatory activity
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Insights and future prospects of Traditional Chinese Medicine in the treatment of Functional Dyspepsia Phytomedicine (IF 7.9) Pub Date : 2024-02-24 Jiaqi Zhang, Ting Chen, Yongtian Wen, Kewin Tien Ho Siah, Xudong Tang
Functional dyspepsia (FD) is a prevalent and challenging gastrointestinal disorder. Conventional medicine often faces limitations in providing effective treatment for FD, thus indicating the need to explore alternative approaches. Traditional Chinese medicine (TCM), which is rooted in ancient Chinese traditions and has evolved over thousands of years, offers a holistic approach to well-being. TCM incorporates
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Traditional Chinese medicine and mitophagy: A novel approach for cardiovascular disease management Phytomedicine (IF 7.9) Pub Date : 2024-02-24 Jinhui Wang, Junbo Zou, Yajun Shi, Nan Zeng, Dongyan Guo, He Wang, Chongbo Zhao, Fei Luan, Xiaofei Zhang, Jing Sun
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, imposing an enormous economic burden on individuals and human society. Laboratory studies have identified several drugs that target mitophagy for the prevention and treatment of CVD. Only a few of these drugs have been successful in clinical trials, and most studies have been limited to animal and cellular
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The Sanbi Decoction alleviates intervertebral disc degeneration in rats through intestinal flora and serum metabolic homeostasis modulation Phytomedicine (IF 7.9) Pub Date : 2024-02-24 Nan Wang, Shuang Chen, Yimin Xie, Xin Liu, Zhipeng Xi, Jingchi Li, Congyang Xue, Rongrong Deng, Wen Min, Ran Kang, Lin Xie
Intervertebral disc degeneration (IVDD) is an essential cause of low back pain (LBP), the incidence of which has risen in recent years and is progressively younger, but treatment options are limited, placing a serious economic burden on society. Sanbi decoction (SBD) is an important classical formula for the treatment of IVDD, which can significantly improve patients' symptoms and is a promising alternative
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The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK/mTOR mediated autophagy Phytomedicine (IF 7.9) Pub Date : 2024-02-24 Hongwei Duan, Shanshan Yang, Shuai Yang, Jianlin Zeng, Zhenxing Yan, Lihong Zhang, Xiaofei Ma, Weitao Dong, Yong Zhang, Xingxu Zhao, Junjie Hu, Longfei Xiao
Oxidative stress is considered the main cause of granulosa cell apoptosis in ovarian disease. Curcumin has various biological roles, but its potential role in protecting granulosa cells from oxidative damage remains unidentified. The study revealed the protective effect of curcumin on granulosa cell survival under oxidative stress, and explored its mode of action. The protective effect of curcumin
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Effectively α-Terpineol Suppresses Glioblastoma Aggressive Behavior and Downregulates KDELC2 Expression Phytomedicine (IF 7.9) Pub Date : 2024-02-23 Jong-Shiaw Jin, Yu-Ling Tsai, Ying-Chuan Chen, Ying Chen, Jiann-Ruey Ong, Jung-Mao Chou, Wen-Chiuan Tsai
Glioblastoma (GBM) is notorious for the aggressive behaviors and easily results in chemo-resistance. Studies have shown that the use of herbal medicines as treatments for GBM as limited by the blood-brain barrier (BBB) and glioma stem cells. The aim of this study was to investigate the relationship between GBM suppression and α-terpineol, the monoterpenoid alcohol derived from and . Using serial and
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Warfarin- A Natural Anticoagulant: A Review of Research Trends for Precision Medication Phytomedicine (IF 7.9) Pub Date : 2024-02-23 Ling Xue, Rajeev K. Singla, Shan He, Sonia Arrasate, Humberto González-Díaz, Liyan Miao, Bairong Shen
Warfarin is a widely prescribed anticoagulant in the clinic. It has a more considerable individual variability, and many factors affect its variability. Mathematical models can quantify the quantitative impact of these factors on individual variability. The aim is to comprehensively analyze the advanced warfarin dosing algorithm based on pharmacometrics and machine learning models of personalized warfarin
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Efficacy and safety of Qushi Huayu, a traditional Chinese medicine, in patients with nonalcoholic fatty liver disease in a randomized controlled trial Phytomedicine (IF 7.9) Pub Date : 2024-02-23 Qiaohong Liu, Xiaojing Li, Yuqing Pan, Qian Liu, Ying Li, Cong He, Ningning Zheng, Yan Wang, Huichao Wang, Yan Wang, Lili Sheng, Binbin Zhang, Tianbai Shen, Gaosong Wu, Houkai Li, Xiaosu Wang, Wei Zhang, Yiyang Hu, Yu Zhao
The effective treatment of non-alcoholic fatty liver disease (NAFLD) is an unmet medical need. Qushi Huayu (QSHY) is an empirical herbal formula with promising effects in NAFLD rodent models and a connection to gut microbiota regulation. This study aimed to evaluate the effects of QSHY in patients with NAFLD through a multicenter, randomized, double-blind, double-dummy clinical trial. A total of 246
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Ginsenosides from Panax ginseng as potential therapeutic candidates for the treatment of inflammatory bowel disease Phytomedicine (IF 7.9) Pub Date : 2024-02-23 Zhiqiang Niu, Yanan Liu, Ruyi Shen, Xiaojian Jiang, Yanting Wang, Ziliang He, Junyao Li, Yeye Hu, Ji Zhang, Yunyao Jiang, Weicheng Hu, Chuanling Si, Shuai Wei, Ting Shen
Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the intestine, which significantly affects patients' quality of life. As a perennial plant with the homology of medicine and food, is known for its substantial anti-inflammatory effects in various inflammatory disorders. Ginsenosides, the main bioactive compounds of , are recognized for their efficacy in ameliorating inflammation
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Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2/xCT/GPX4 signaling pathway Phytomedicine (IF 7.9) Pub Date : 2024-02-22 Yanyan Deng, Xiayan Chu, Qian Li, Guanghao Zhu, Jing Hu, Jianming Sun, Hairong Zeng, Jian Huang, Guangbo Ge
As a canonical iron-dependent form of regulated cell death (RCD), ferroptosis plays a crucial role in chemical-induced liver injuries. Previous studies have demonstrated that xanthohumol (Xh), a natural prenylflavonoid isolated from hops, exhibits anti-inflammatory, anti-antioxidative and hepatoprotective properties. However, the regulatory effects of Xh on hepatic ferroptosis and the underlying mechanism
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Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial–mesenchymal transition Phytomedicine (IF 7.9) Pub Date : 2024-02-22 Ya-xin Shi, Li Xu, Xin Wang, Ke-ke Zhang, Cheng-yuan Zhang, Hong-yun Liu, Ping-ping Ding, Wei Shi, Zhi-yong Liu
The active ingredients of the Chinese medical herb ethanol extract (PPE) and polyphyllin I (PPI), potentially inhibit epithelial–mesenchymal transition (EMT) in tumors. However, the roles of these ingredients in inhibiting EMT in adenomyosis (AM) remain to be explored. The primary goal of the study was to uncover the underlying molecular processes through which PPE and PPI suppress EMT in AM, alongside
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Mitigating phospholipid peroxidation of macrophages in stress-induced tumor microenvironment by natural ALOX15/PEBP1 complex inhibitors Phytomedicine (IF 7.9) Pub Date : 2024-02-22 Xiang Luo, Dong-Dong Li, Zi-Chun Li, Zi-Xuan Li, De-Hua Zou, Feng Huang, Guan Wang, Rong Wang, Yun-Feng Cao, Wan-Yang Sun, Hiroshi Kurihara, Lei Liang, Yi-Fang Li, Wen Jin, Yan-Ping Wu, Rong-Rong He
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Effect of resveratrol on herpesvirus encephalitis: evidences for its mechanisms of action Phytomedicine (IF 7.9) Pub Date : 2024-02-22 Ziwei Huang, Shan Li, Lishan Zhong, Yuan Su, Menghe Li, Xiaohui Wang, Zexu Wang, Zhiping Wang, Cuifang Ye, Zhe Ren, Xiao Wang, Qiongzhen Zeng, Kai Zheng, Yifei Wang
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Ethyl-acetate extract of Spatholobi Caulis blocked the pro-metastatic support from the hemato-microenvironment of colon cancer by specific disruption of tumor-platelet adhesion Phytomedicine (IF 7.9) Pub Date : 2024-02-22 Sun Lidong, Yang Lina, Du Xinke, Liu Li, Ran QingSen, Yang Qing, Chen Ying, Zhu XiaoXin, Li Qi
Within the pro-metastatic hemato-microenvironment, interaction between platelets and tumor cells provides essential support for tumor cells by inducing Epithelial-Mesenchymal Transition (EMT), which greatly increases the stemness of colon cancer cells. Pharmacologically, although platelet deactivation has proved to be benefit against metastasis, its wide application is severely restricted due to the
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Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells Phytomedicine (IF 7.9) Pub Date : 2024-02-21 Maolei Xu, Weilan Zhong, Chen Yang, Ming Liu, Xiaoqing Yuan, Tao Lu, Desheng Li, Guanqing Zhang, Huan Liu, Yuying Zeng, Xiaoping Yang, Yufu Zhou, Ling Zhou
Tiliroside (TIL) is a flavonoid compound that exists in a variety of edible plants. These dietary plants are widely used as food and medicine to treat various diseases. However, the effect of TIL on pancreatic cancer (PC) and its underlying mechanisms are unclear. This study aims to reveal the anti-PC effect of TIL and clarify its mechanism. The inhibitory effects of TIL on PC growth were studied both
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Aucubin alleviates doxorubicin-induced cardiotoxicity through crosstalk between NRF2 and HIPK2 mediating autophagy and apoptosis Phytomedicine (IF 7.9) Pub Date : 2024-02-21 Weili Li, Jing Cao, Yawen Zhang, Guanjing Ling, Nannan Tan, Yan Wei, Yuqin Zhang, Xiaoping Wang, Weina Qian, Jinchi Jiang, Jingmei Zhang, Wei Wang, Yong Wang
Doxorubicin (DOX) is widely used for the treatment of a variety of cancers. However, its clinical application is limited by dose-dependent cardiotoxicity. Recent findings demonstrated that autophagy inhibition and apoptosis of cardiomyocytes induced by oxidative stress dominate the pathophysiology of DOX-induced cardiotoxicity (DIC), however, there are no potential molecules targeting on these. This
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Arenobufagin inhibits lung metastasis of colorectal cancer by targeting c-MYC/Nrf2 axis Phytomedicine (IF 7.9) Pub Date : 2024-02-21 Mei Wang, Siyi Hu, Jiawang Yang, Liang Yuan, Limin Han, Feng Liang, Fenglin Zhang, Hailong Zhao, Yun Liu, Ning Gao
Colorectal cancer (CRC) is one of the commonest cancers worldwide. Metastasis is the most common cause of death in patients with CRC. Arenobufagin is an active component of bufadienolides, extracted from toad skin and parotid venom. Arenobufagin reportedly inhibits epithelial-to-mesenchymal transition (EMT) and metastasis in various cancers. However, the mechanism through which arenobufagin inhibits
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Alleviation of allergic asthma by rosmarinic acid via gut-lung axis Phytomedicine (IF 7.9) Pub Date : 2024-02-20 Hui-Hui Guo, Yan-Xing Han, Xiao-Juan Rong, Zhen Shen, Hao-Ran Shen, Ling-Fei Kong, Yun- Dan Guo, Ji-Zhou Li, Bo Xu, Tian-Le Gao, Lu-Lu Wang, Cai Tie, Jian-Dong Jiang
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Quercitrin improves cardiac remodeling following myocardial infarction by regulating macrophage polarization and metabolic reprogramming Phytomedicine (IF 7.9) Pub Date : 2024-02-19 Congyong Liu, Jungang Huang, Junxiong Qiu, Huiqi Jiang, Shi Liang, Yangfan Su, Jun Lin, Junmeng Zheng
The death and disability caused by myocardial infarction is a health problem that needs to be addressed worldwide, and poor cardiac repair and fibrosis after myocardial infarction seriously affect patient recovery. Postmyocardial infarction repair by M2 macrophages is of great significance for ventricular remodeling. Quercitrin (Que) is a common flavonoid in fruits and vegetables that has antioxidant
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Yi-Qi-Huo-Xue decoction alleviates intracerebral hemorrhage injury through inhibiting neuronal autophagy of ipsilateral cortex via BDNF/TrkB pathway Phytomedicine (IF 7.9) Pub Date : 2024-02-19 Dan Han, Xinyue Chang, Dan Xu, Ali Fan, Meihua Wang, Dingran Li, Xiangkai Chen, Cheng Wang, Yi Wu, Jizhong Shen, Zhaocong Yang, Jian Li, Siliang Wang
Yi-Qi-Huo-Xue Decoction (YQHXD), a traditional Chinese medicine formula, has demonstrated efficacy in the clinical treatment of intracerebral hemorrhage (ICH) for over a decade. Nevertheless, the precise pharmacotherapeutic compounds of YQHXD capable of penetrating into cerebral tissue and the pharmacological underpinnings of YQHXD remain ambiguous. The active components of YQHXD in rat brains was
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Exploring the pathophysiological influence of heme oxygenase-1 on neuroinflammation and depression: A study of phytotherapeutic-based modulation Phytomedicine (IF 7.9) Pub Date : 2024-02-19 Jiao Wang, Tapan Behl, Tarapati Rana, Aayush Sehgal, Pranay Wal, Bhagawati Saxena, Shivam Yadav, Syam Mohan, Md. Khalid Anwer, Sridevi Chigurupati, Imran Zaheer, Bairong Shen, Rajeev K. Singla
The heme oxygenase (HO) system plays a significant role in neuroprotection and reduction of neuroinflammation and neurodegeneration. The system, via isoforms HO-1 and HO-2, regulates cellular redox balance. HO-1, an antioxidant defense enzyme, is highlighted due to its association with depression, characterized by heightened neuroinflammation and impaired oxidative stress responses. We observed the
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Efficacy and Safety of Pien Tze Huang Capsules in Patients with Herpes Zoster: A Multicenter, Randomized, Double-Blinded, and Placebo-Controlled Trial Phytomedicine (IF 7.9) Pub Date : 2024-02-17 Wenfeng Wu, Dingquan Yang, Daoshun Sui, Minghua Zhu, Guangpu Luo, Zhonghui Yang, Yongfeng Wang, Hong Luo, Li Ling, Zexin Zhang, Yanmei Wu, Guoming Feng, Hongyi Li
Herpes zoster (HZ) is a common medical condition accompanied by several distressing symptoms, including acute pain. Pien Tze Huang (PZH) is a well-known traditional Chinese medicine (TCM) with numerous pharmacological effects, including antiviral properties, neuroprotection, and immunity regulation. To investigate the efficacy and safety of PZH capsules in patients with HZ. A multicenter, double-blinded