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A review on toxicity mechanism and risk factors of nanoparticles in respiratory tract Toxicology (IF 4.5) Pub Date : 2024-03-15 Vidyasri Khadanga, Purna Chandra Mishra
This comprehensive review focuses on various dimensions of nanoparticle toxicity, emphasizing toxicological characteristics, assessment techniques, and examinations of relevant studies on the effects on biological systems. The primary objective is to comprehend the potential risks associated with nanoparticles and to provide efficient strategies for mitigating them by consolidating current research
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Metabolism-dependent mutagenicity of two structurally similar tobacco-specific nitrosamines (N-nitrosonornicotine and N-nitrosoanabasine) in human cells, partially different CYPs being activating enzymes Toxicology (IF 4.5) Pub Date : 2024-03-13 Yijing Chen, Zongying Yang, Zhao Zhou, Ellery J. Liu, Wenwen Luo, Zhini He, Weili Han, Yungang Liu
-nitrosonornicotine (NNN) and -nitrosoanabasine (NAB) are both tobacco-specific nitrosamines bearing two heterocyclic amino groups, NAB bearing an extra -CH- group (conferring a hexa- rather than penta-membered cycle) but with significantly decreased carcinogenicity. However, their activating enzymes and related mutagenicity remain unclear. In this study, the chemical-CYP interaction was analyzed by
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Genotoxic and cytotoxic effects of aflatoxin on the reproductive system: Focus on cell cycle dynamics and apoptosis in testicular tissue Toxicology (IF 4.5) Pub Date : 2024-03-12 Cyrus Jalili, Rahele Ranjbar shamsi, Bita Amiri, Seyran Kakebaraie, Faramarz Jalili, Touraj Zamir Nasta
Aflatoxins (AFs) are inevitable environmental contaminants that are detrimental to human and animal health. AFs interfere with metabolic processes, metabolizing into different hydroxylated derivatives in the liver, as well as mechanistically induce ROS accumulation, S-phase arrest, DNA damage, and cell apoptosis. Chronic consumption of aflatoxin-contaminated foods can adversely affect the male reproductive
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Metabolic alterations and mitochondrial dysfunction in human airway BEAS-2B cells exposed to vanadium pentoxide Toxicology (IF 4.5) Pub Date : 2024-03-11 Xiaojia He, Matthew Ryan Smith, Zachery R. Jarrell, ViLinh Thi Ly, Yongliang Liang, Choon-Myung Lee, Michael Orr, Young-Mi Go, Dean P. Jones
Vanadium pentoxide (V) is a hazardous material that has drawn considerable attention due to its wide use in industrial sectors and increased release into environment from human activities. It poses potential adverse effects on animals and human health, with pronounced impact on lung physiology and functions. In this study, we investigated the metabolic response of human bronchial epithelial BEAS-2B
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Prediction of Acute Methanol Poisoning Prognosis Using machine learning techniques Toxicology (IF 4.5) Pub Date : 2024-03-06 Mitra Rahimi, Sayed Masoud Hosseini, Seyed Ali Mohtarami, Babak Mostafazadeh, Peyman Erfan Talab Evini, Mobin Fathy, Arya Kazemi, Sina Khani, Seyed Mohammad Mortazavi, Amirali Soheili, Seyed Mohammad Vahabi, Shahin Shadnia
Methanol poisoning is a global public health concern, especially prevalent in developing nations. This study focuses on predicting the severity of methanol intoxication using machine learning techniques, aiming to improve early identification and prognosis assessment. The study, conducted at Loghman Hakim Hospital in Tehran, Iran. The data pertaining to individuals afflicted with methanol poisoning
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Influence of lead-induced toxicity on the inflammatory cytokines Toxicology (IF 4.5) Pub Date : 2024-03-05 P. Harshitha, Kalpita Bose, Herman Sunil Dsouza
Lead (Pb) is a hazardous heavy metal that is pervasive in the human environment as a result of anthropogenic activity, and poses serious health risks, particularly in children. Due to its innumerable unique physical and chemical properties, it has various applications; therefore, it has become a common environmental pollutant. Lead may cause oxidative stress, and accumulating evidence indicates that
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Bee venom genotoxicity on Saccharomyces cerevisiae cells – The role of mitochondria and YAP1 transcription factor Toxicology (IF 4.5) Pub Date : 2024-03-03 Teodora Todorova, Krassimir Boyadzhiev, Martin Dimitrov, Petya Parvanova
The present work aims to clarify the genotype differences of a model organism in response to bee venom.
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Ferrostatin‑1 alleviates liver injury via decreasing ferroptosis following ricin toxin poisoning in rat Toxicology (IF 4.5) Pub Date : 2024-03-02 Ruijiao Lin, Zijie Jia, Hongbing Chen, Hongli Xiong, Cunhao Bian, Xin He, Bi Wei, Junfeng Fu, Minzhu Zhao, Jianbo Li
Ricin is a highly toxic plant toxin that can cause multi-organ failure, especially liver dysfunction, and is a potential bioterrorism agent. Despite the serious public health challenge posed by ricin, effective therapeutic for ricin-induced poisoning is currently unavailable. Therefore, it is important to explore the mechanism of ricin poisoning and develop appropriate treatment protocols accordingly
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Influence of polystyrene nanoparticles on the toxicity of tetrabromobisphenol A in human intestinal cell lines Toxicology (IF 4.5) Pub Date : 2024-03-02 Patricia Soto-Bielicka, Ana Peropadre, Soledad Sanz-Alférez, María José Hazen, Paloma Fernández Freire
Research and regulatory efforts in toxicology are increasingly focused on the development of suitable non-animal methodologies for human health risk assessment. In this work we used human intestinal Caco-2 and HT29/MTX cell lines to address the potential risks of mixtures of the emerging contaminants tetrabromobisphenol A (TBBPA) and commercial polystyrene nanoparticles (PSNPs). We employed different
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Virtual display of targets: A new level to rise the current understanding of ochratoxin A toxicity from a molecular standpoint Toxicology (IF 4.5) Pub Date : 2024-03-02 Florinda Perugino, Lorenzo Pedroni, Gianni Galaverna, Chiara Dall’Asta, Luca Dellafiora
Ochratoxin A (OTA) is a mycotoxin spread worldwide contaminating several food and feed commodities and rising concerns for humans and animals. OTA toxicity has been thoroughly assessed over the last 60 years revealing a variety of adverse effects, including nephrotoxicity, hepatotoxicity and possible carcinogenicity. However, the underpinning mechanisms of action have yet to be completely displayed
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Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats Toxicology (IF 4.5) Pub Date : 2024-03-01 Samyah T. Alanazi, Samir A. Salama, Ahmed Magdy El-ebiary, Abdulelah K. Altowairqi, Atheer T. Alharthi, Shahad M. Alzahrani, Shomokh H. Althagafi, Reema A. Alotaibi, Ahmed Abd-Eltawab Tammam
Blood transfusion-requiring diseases such as sickle cell anemia and thalassemia are characterized by an imbalance between iron intake and excretion, resulting in an iron overload (IOL) disorder. Hepatotoxicity is prevalent under the IOL disorder because of the associated hepatocellular redox and inflammatory perturbation. The current work was devoted to investigate the potential protection against
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Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches Toxicology (IF 4.5) Pub Date : 2024-02-28 Rita Ortega-Vallbona, Rebeca Méndez, Laia Tolosa, Sylvia E. Escher, José V. Castell, Rafael Gozalbes, Eva Serrano-Candelas
Hepatotoxicity poses a significant concern in drug design due to the potential liver damage that can be caused by new drugs. Among common manifestations of hepatotoxic damage is lipid accumulation in hepatic tissue, resulting in liver steatosis or phospholipidosis. Carboxylic derivatives are prone to interfere with fatty acid metabolism and cause lipid accumulation in hepatocytes. This study investigates
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Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types Toxicology (IF 4.5) Pub Date : 2024-02-27 Lucie C. Ford, Hsing-Chieh Lin, Han-Hsuan D. Tsai, Yi-Hui Zhou, Fred A. Wright, Alexander Sedykh, Ruchir R. Shah, Weihsueh A. Chiu, Ivan Rusyn
Per- and poly-fluoroalkyl substances (PFAS) are extensively used in commerce leading to their prevalence in the environment. Due to their chemical stability, PFAS are considered to be persistent and bioaccumulative; they are frequently detected in both the environment and humans. Because of this, PFAS as a class (composed of hundreds to thousands of chemicals) are contaminants of very high concern
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Cuproptosis-associated hub gene identification and immune cell infiltration patterns in silicosis Toxicology (IF 4.5) Pub Date : 2024-02-23 Ruimin Ma, Di Sun, Yuanying Wang, Xiaoxi Huang, Qiao Ye
Recent research has hinted at a potential connection between silicosis, a fibrotic lung disease caused by exposure to crystalline silica particles, and cuproptosis. The aim of the study was to explore how cuproptosis-related genes (CRGs) may influence the development of silicosis and elucidate the underlying mechanisms. An analysis of genes associated with both silicosis and cuproptosis was conducted
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Recreational MDMA doses do not elicit hepatotoxicity in HepG2 spheroids under normo- and hyperthermia Toxicology (IF 4.5) Pub Date : 2024-02-23 Arthur L. de Oliveira, Raul G. Miranda, Daniel J. Dorta
MDMA (3,4-methylenedioxymethamphetamine), an entactogen with empathogenic and prosocial effects, is widely used in music festivals and other festive settings. High MDMA doses have been associated with drug-induced liver injury and cases of hyperthermia. Although the latter condition is thought to increase MDMA hepatotoxicity, this correlation remains poorly explored for recreational MDMA doses. On
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Insights into the Mechanism of Transcription Factors in Pb2+-Induced Apoptosis Toxicology (IF 4.5) Pub Date : 2024-02-21 Jingchong Guo, Ruikang Li, Zhuqing Ouyang, Jiawen Tang, Wei Zhang, Hui Chen, Qian Zhu, Jing Zhang, Gaochun Zhu
The health risks associated with exposure to heavy metals, such as Pb, are increasingly concerning the public. Pb can cause significant harm to the human body through oxidative stress, autophagy, inflammation, and DNA damage, disrupting cellular homeostasis and ultimately leading to cell death. Among these mechanisms, apoptosis is considered crucial. It has been confirmed that transcription factors
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The m6A reader IGF2BP1 attenuates the stability of RPL36 and cell proliferation to mediate benzene hematotoxicity by recognizing m6A modification Toxicology (IF 4.5) Pub Date : 2024-02-16 Jingyu Wang, Xiaoli Guo, Yujiao Chen, Wei Zhang, Jing Ren, Ai Gao
Benzene exposure leads to hematotoxicity, and epigenetic modification is considered to be a potential mechanism of benzene pathogenesis. As a newly discovered post-transcriptional modification, the roles of N6-methyladenosine (m6A) in benzene hematotoxicity are still unclear. m6A can only exert its gene regulatory function after being recognized by m6A reading proteins. In this study, we found that
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Exposure to TCBPA stimulates the growth of arterial smooth muscle cells through the activation of the ROS/NF-κB/NLRP3 signaling pathway Toxicology (IF 4.5) Pub Date : 2024-02-16 Huanyu Qiao, Bo Yang, Xiaoshuo Lv, Yongmin Liu
Tetrachlorobisphenol A (TCBPA) and Tetrabromobisphenol S (TBBPS) are organic compounds widely used in industrial production, including in plastic and textile manufacturing. Presently, residual TCBPA is commonly detected in the environment as well as in human and animal sera. Therefore, it is imperative to assess the potential toxicological effects of TCBPA on organismal health. A series of biochemical
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Toxicovigilance 2.0 – modern approaches for the hazard identification and risk assessment of toxicants in human beings: A review Toxicology (IF 4.5) Pub Date : 2024-02-16 Łukasz Niżnik, Joanna Toporowska-Kaźmierak, Karolina Jabłońska, Natalia Głąb, Sabina Stach, Julia Florek, Marta Sowińska, Aleksandra Adamczyk, Kamil Jurowski
The attempt to define toxicovigilance can be based on defining its fundamental principles: prevention of infections with toxic substances, collecting information on poisonings, both in terms of their sources and side effects, and confirming poisonings, with the aim of improving treatment. Substances referred to include both those originating from animal bites, ingested inadvertently, and those resulting
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Multiple organs injury and myocardial energy metabolism disorders induced by isoproterenol Toxicology (IF 4.5) Pub Date : 2024-02-16 Xiao-ting Zhang, Xu Zhang, Meng-wei Wang, Chen Zhang, Rui Weng, Xu Xu, Zu-xi Gu, Jian-ping Gao
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Metformin inhibits OCTN1- and OCTN2-mediated hepatic accumulation of doxorubicin and alleviates its hepatotoxicity in mice Toxicology (IF 4.5) Pub Date : 2024-02-15 Mingyang Chen, Yaodong Yi, Binxin Chen, Hengbin Zhang, Minlei Dong, Luexiang Yuan, Hui Zhou, Huidi Jiang, Zhiyuan Ma
Doxorubicin (DOX) is a widely used antitumor agent; however, its clinical application is limited by dose-related organ damage. Because organic cation/carnitine transporters (OCTN1 and OCTN2), which are critical for DOX uptake, are highly expressed in hepatocytes, we aimed to elucidate the role of these transporters in hepatic DOX uptake. The results indicated that inhibitors and RNA interference both
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Identification of toxicity-induced biomarkers in human non-immune airway cells exposed to respiratory sensitizers: a mechanistic approach Toxicology (IF 4.5) Pub Date : 2024-02-14 Artur Christian Garcia da Silva, Sérgio de Morais Carvalho Filho, Izadora Caroline Furtado de Mendonça, Marize Campos Valadares
Occupational asthma covers a group of work-related diseases whose clinical manifestations include airway hyperresponsiveness and airflow limitation. Although the chemical respiratory allergy (CRA) induced by Low Molecular Weight (LMW) sensitizers is a major concern, especially in terms of the regulatory framework, to date there are no methods available for preclinically addressing this toxicological
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Could the gut microbiota be capable of making individuals more or less susceptible to environmental toxicants? Toxicology (IF 4.5) Pub Date : 2024-02-13 Marcella S.A Santiago, Maria Christina W. Avellar, Juliana E. Perobelli
Environmental toxicants are chemical substances capable to impair environmental quality and exert adverse effects on humans and other animals. The main routes of exposure to these pollutants are through the respiratory tract, skin, and oral ingestion. When ingested orally, they will encounter trillions of microorganisms that live in a community - the gut microbiota (GM). While pollutants can disrupt
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A novel three-dimensional Nrf2 reporter epidermis model for skin sensitization assessment Toxicology (IF 4.5) Pub Date : 2024-02-09 K. Brandmair, D. Dising, D. Finkelmeie, A. Schepky, J. Kuehnl, J. Ebmeyea, A. Burger-Kentischer
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miR-15b-5p promotes HgCl2-induced chicken embryo kidney cells ferroptosis by targeting β-TrCP-mediated ATF4 ubiquitin degradation Toxicology (IF 4.5) Pub Date : 2024-02-06 Hong-Yu Fu, Yue Li, Han Cui, Jiu-Zhi Li, Wan-Xue Xu, Xi Wang, Rui-Feng Fan
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Notoginsenoside R1 attenuates bupivacaine induced neurotoxicity by activating Jak1/Stat3/Mcl1 pathway Toxicology (IF 4.5) Pub Date : 2024-02-04 Yu Yang, Jiwen Wu, Shicheng Feng, Hao Yu, Chuanxin Liu, Shuai Wang
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Restoration of nerve agent impaired neuromuscular transmission in rat diaphragm by bispyridinium non-oximes – Structure-activity relationships Toxicology (IF 4.5) Pub Date : 2024-02-03 Niko Amend, Christopher M. Timperley, Mike Bird, A. Christopher Green, Franz Worek, Thomas Seeger
Organophosphate (OP) poisoning is currently treated with atropine, oximes and benzodiazepines. The nicotinic signs, i.e., respiratory impairment, can only be targeted indirectly via the use of oximes as reactivators of OP-inhibited acetylcholinesterase. Hence, compounds selectively targeting nicotinic acetylcholine receptors (nAChRs) might fundamentally improve current treatment options. The bispyridinium
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Differential eigengene network analysis reveals benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin consensus regulatory network in human liver cell line HepG2 Toxicology (IF 4.5) Pub Date : 2024-02-02 Bojana Stanic, Nataša Sukur, Nemanja Milošević, Jelena Markovic Filipovic, Kristina Pogrmic-Majkic, Nebojsa Andric
Aryl hydrocarbon receptor (AHR) is one of the main mediators of the toxic effects of benzo[]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD). However, a vast number of BaP- and TCDD-affected genes may suggest a more complex transcriptional regulatory network driving common adverse effects of these two chemicals. Unlike TCDD, BaP is rapidly metabolized in the liver, yielding products with
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Development of a hierarchical support vector regression-based in silico model for the prediction of the cysteine depletion in DPRA Toxicology (IF 4.5) Pub Date : 2024-02-02 Giang H. Ta, Ching-Feng Weng, Max K. Leong
Topical and transdermal treatments have been dramatically growing recently and it is crucial to consider skin sensitization during the drug discovery and development process for these administration routes. Various tests, including animal and non-animal approaches, have been devised to assess the potential for skin sensitization. Furthermore, numerous models have been created, providing swift and cost-effective
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Deep Learning Algorithm Based on Molecular Fingerprint for Prediction of Drug‐Induced Liver Injury Toxicology (IF 4.5) Pub Date : 2024-02-01 Qiong Yang, Shuwei Zhang, Yan Li
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Ochratoxin A stimulates release of IL-1β, IL–18 and CXCL8 from cultured human microglia Toxicology (IF 4.5) Pub Date : 2024-02-01 Irene Tsilioni, Theoharis C. Theoharides
Exposure to mycotoxins has been associated with the development of neuropsychiatric symptoms and Ochratoxin A (OTA) has emerged as one of the main mycotoxins associated with neurotoxicity. However, the mechanism via OTA exerts its neurotoxic effects is not well understood, especially the importance of activated microglia and their contribution to neuroinflammation. Here we report the effect of OTA
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Exploring the dynamics of the ABCB1 membrane transporter P-glycoprotein in the presence of ATP and active/non-active compounds through molecular dynamics simulations Toxicology (IF 4.5) Pub Date : 2024-01-24 Liadys Mora Lagares, Yunierkis Pérez-Castillo, Marjana Novič
P-glycoprotein (Pgp) is a member of the ATP-binding cassette family of transporters that confers multidrug resistance to cancer cells and is actively involved in the pharmacokinetics and toxicokinetics of a big variety of drugs. Extensive studies have provided insights into the binding of many compounds, but the precise mechanism of translocation across the membrane remains unknown; in this context
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Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine Toxicology (IF 4.5) Pub Date : 2024-01-28 Jing He, Yunyun Ma, Xudong Niu, Jiansheng Pei, Ru Yan, Fangjing Xu, Jing Ma, Xiaojuan Ma, Shaobin Jia, Wanrui Ma
Silver nanoparticles (AgNPs) are used increasingly often in the biomedical field, but their potential deleterious effects on the cardiovascular system remain to be elucidated. The primary aim of this study was to evaluate the toxic effects, and the underlying mechanisms of these effects, of AgNPs on human umbilical vein endothelial cells (HUVECs), as well as the protective role of N-acetylcysteine
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Dimethyl fumarate induces cardiac developmental toxicity in zebrafish via down-regulation of oxidative stress Toxicology (IF 4.5) Pub Date : 2024-01-23 Mengqi Wan, Jiejun Liu, Dou Yang, Zhonghao Xiao, Xue Li, Jieping Liu, Ling Huang, Fasheng Liu, Shouhua Zhang, Qiang Tao, Juhua Xiao, Zigang Cao
Dimethyl fumarate (DMF) is an immunosuppressant commonly used to treat multiple sclerosis and other autoimmune diseases. Despite known side effects such as lymphopenia, the effect of DMF on cardiac development remains unclear. To assess this, we used zebrafish to evaluate the cardiac developmental toxicity of DMF. Our study showed that DMF reduced the survival rate of zebrafish embryos, with those
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Sex differences in 4-tert-octylphenol toxicokinetics: Exploration of sex as an effective covariate through an in vivo modeling approach Toxicology (IF 4.5) Pub Date : 2024-01-20 Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee
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Exploring the multifaceted impact of lanthanides on physiological pathways in human breast cancer cells Toxicology (IF 4.5) Pub Date : 2024-01-20 Yi-Ming Huang, Tsu-Yu Hsu, Ching-Yu Liu, Yu-Chen Hsieh, Kuan-Yun Lai, Ya-Wen Yang, Kai-Yin Lo
Lanthanum (La) and cerium (Ce), rare earth elements with physical properties similar to calcium (Ca), are generally considered non-toxic when used appropriately. However, their ions possess anti-tumor capabilities. This investigation explores the potential applications and mechanisms of LaCl3 or CeCl3 treatment in triple-negative breast cancer (TNBC) cell lines. TNBC, characterized by the absence of
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Autophagy alleviates hippocampal neuroinflammation by inhibiting the NLRP3 inflammasome in a juvenile rat model exposed particulate matter Toxicology (IF 4.5) Pub Date : 2024-01-17 Jianxiong Gui, Jie Liu, Lingman Wang, Xiaoyue Yang, Bing Tian, Hanyu Luo, Dishu Huang, Ziyao Han, Jiaxin Yang, Ran Ding, Zhixu Fang, Xue Li, Li Cheng, Li Jiang
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Protective effects of vitamin E against acrylamide-induced hepatotoxicity and nephrotoxicity from fetal development to adulthood: Insights into Akt/NF-κB and Bcl-xL/Bax signaling pathways Toxicology (IF 4.5) Pub Date : 2024-01-18 Nuray Üremi̇ş, Muhammed Mehdi Üremi̇ş, Mehmet Gül, Eda Nur Özsoy, Yusuf Türköz
Acrylamide (ACR), a toxin present in fried and baked carbohydrate-rich foods, is known to cause liver and kidney damage. This study aimed to investigate the mechanisms of oxidative stress, inflammation, and apoptosis that contribute to liver and kidney damage induced by chronic administration of ACR. Additionally, the effectiveness of vitamin E in mitigating these toxic effects was examined. The study
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Ferroptosis at the crossroads of manganese-induced neurotoxicity: A retrospective study Toxicology (IF 4.5) Pub Date : 2024-01-10 Yaoyang Liu, Shanyu Lv, Guoguo He, Changyong Wang, Chaoyan Ou
Manganese is an essential trace element, but overexposure can cause neurotoxicity and subsequent neurodegenerative diseases. Ferroptosis is a form of cell death characterized by lipid peroxidation and iron overload inside cells, which is closely related to manganese neurotoxicity. Manganese can induce ferroptosis through multiple pathways: causing oxidative stress and increased cellular reactive oxygen
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Gut microbiota dysbiosis and intestinal barrier impairment in diarrhea caused by cold drink and high-fat diet Toxicology (IF 4.5) Pub Date : 2024-01-10 Yajuan Tian, Meng Fu, Jie Su, Meiqiu Yan, Jingjing Yu, Chenxing Wang, Zhuangwei Niu, Yuzhong Du, Xueling Hu, Jiayi Zheng, Bai Tao, Zengguang Gao, Jianzhen Chen, Suhong Chen, Guiyuan Lv
Cold drink and high-fat diet (CDHFD) are common diet patterns. However, the potential risks remain unclear. We investigated the effects of CDHFD in adult mice and explored the mechanisms of action. Twenty adult male mice were randomly divided into control and model groups, and the control group was fed a normal diet, whereas the model group was fed CDHFD for 28 days. We found that mice in the model
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Are the BPA analogues an alternative to classical BPA? Comparison between 2D and alternative 3D in vitro neuron model to assess cytotoxic and genotoxic effects Toxicology (IF 4.5) Pub Date : 2024-01-09 Marta Sendra, Mónica Cavia-Saiz, Pilar Múñiz
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Mechanism of cadmium-induced nephrotoxicity Toxicology (IF 4.5) Pub Date : 2024-01-06 Claudia J. Bautista, Nidia Arango, Consuelo Plata, Irma B. Mitre-Aguilar, Joyce Trujillo, Victoria Ramírez
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Distinct bile acid alterations in response to a single administration of PFOA and PFDA in mice Toxicology (IF 4.5) Pub Date : 2024-01-03 Xiaoxiao Yu, Youcai Zhang, Bruno Cogliati, Curtis D. Klaassen, Sanaya Kumar, Xingguo Cheng, Pengli Bu
Per- and polyfluoroalkyl substances (PFASs), a group of synthetic chemicals that were once widely used for industrial purposes and in consumer products, are widely found in the environment and in human blood due to their extraordinary resistance to degradation. Once inside the body, PFASs can activate nuclear receptors such as PPARα and CAR. The present study aimed to investigate the impact of perfluorooctanoic
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Neurodevelopment effects of early life bisphenol-A exposure on visual memory: Insights into recovery dynamics Toxicology (IF 4.5) Pub Date : 2023-12-30 Wentai Zhang, Linke Zhang, Weifeng Liang, Huan Wang, Fan Hu
Bisphenol A (BPA), a ubiquitous endocrine disruptor, is implicated in the cognitive deficits observed in both children and animals. Especially, BPA-induced spatial memory deterioration during the whole development phase of rodents has been well delineated. However, whether BPA exposure on the different development phases exerts similar effects on the prefrontal cortex (PFC) dependent visual memory
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Chronic Pb exposure impairs learning and memory abilities by inhibiting excitatory projection neuro-circuit of the hippocampus in mice Toxicology (IF 4.5) Pub Date : 2023-12-30 Rong-Xin Zou, Xiaozhen Gu, Chenqing Huang, Hui-Li Wang, Xiang-tao Chen
Lead (Pb) is an environmental neurotoxic metal. Chronic Pb exposure causes behavioral changes in humans and rodents, such as dysfunctional learning and memory. Nevertheless, it is not clear whether Pb exposure disrupts the neural circuit. Thus, here we aim at investigating the effects the chronic Pb exposure on neural-behavioral and neural circuits in mice from prenatal to postnatal day (PND) 63. Pregnant
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Molecular docking study of frequently used food additives for selected targets depending on the chromosomal abnormalities they cause Toxicology (IF 4.5) Pub Date : 2023-12-29 Fatma Okus, Deniz Yuzbasioglu, Fatma Unal
Food additives (FAs) (flavor enhancers, sweeteners, etc.) protect foods during storage and transportation, making them attractive to consumers. Today, while the desire to access natural foods is increasing, the chemicals added to foods have started to be questioned. In this respect, genotoxicity tests have gained importance. Studies show that some food additives may have genotoxic risks. Previous studies
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IL-10-TG/TPO-T4 axis, the target of bis (2-ethylhexyl) tetrabromophthalate on thyroid function imbalance Toxicology (IF 4.5) Pub Date : 2023-12-20 Yuese Yuan, Yimeng Zhuang, Yuan Cui, Yuetong Liu, Qiong Zhang, Qianqian Xiao, Qinghe Meng, Jianjun Jiang, Weidong Hao, Xuetao Wei
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A review of heavy metal risks around e-waste sites and comparable municipal dumpsites in major African cities: Recommendations and future perspectives Toxicology (IF 4.5) Pub Date : 2023-12-18 Emmanuel Sunday Okeke, Adebisi Enochoghene, Brendan Chukwuemeka Ezeudoka, Steve Dokpo Kaka, Yao Chen, Guanghua Mao, Chukwuebuka ThankGod Eze, Weiwei Feng, Xiangyang Wu
In Africa, the effects of informal e-waste recycling on the environment are escalating. It is regularly transported from developed to developing nations, where it is disassembled informally in search of precious metals, thus increasing human exposure to harmful compounds. Africa has a serious problem with e-waste, as there are significant facilities in Ghana and Nigeria where imported e-waste is unsafely
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Assessment of no-observed-effect-levels for DNA adducts formation by genotoxic carcinogens in fetal turkey livers Toxicology (IF 4.5) Pub Date : 2023-12-22 Tetyana Kobets, Christina Hickey, George Johnson, Jian-Dong Duan, Sylvain Etter, Benjamin Smith, Gary M. Williams
For genotoxic carcinogens, covalent binding to DNA is a critical initiating event in tumorigenesis. The present research investigated dose-effect relationships of three genotoxic carcinogens representing different structural classes, 2-acetylaminofluorene (2-AAF), benzo[a]pyrene (B[a]P) and quinoline (QUI), to assess the existence of no-observed-effect-levels (NOELs) for the formation of DNA adducts
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Assessment of the genotoxic and mutagenic effects induced by T-2 mycotoxin in HepG2 cells Toxicology (IF 4.5) Pub Date : 2023-12-19 Mercedes Taroncher, Cristina Fuentes, Yelko Rodríguez-Carrasco, María-José Ruiz
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Multiomics was used to clarify the mechanism by which air pollutants affect chronic obstructive pulmonary disease: A human cohort study Toxicology (IF 4.5) Pub Date : 2023-12-19 Huijun Li, Yanting Yang, Yanpeiyue Yang, Chengkai Zhai, Juan Yao, Wei Liao, Yongbin Wang, Jing Wang, Chenlong Cao, Hany W. Darwish, Wei Wu, Wenlong Li, Beilei Ge, You Ma, Hui Wu, Weidong Wu, Fei Zhai
Exposure to air pollutants has been associated with various adverse health outcomes, including chronic obstructive pulmonary disease (COPD). However, the precise underlying mechanism by which air pollution impacts COPD through remains insufficiently understood. To elucidated the molecular mechanism by which air pollutant exposure contributes to alterations in the gut microbiome and metabolism in AECOPD
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Caspases downregulate nickel and hydrogen peroxide-induced IL-8 production via modification of c-Jun N-terminal kinases Toxicology (IF 4.5) Pub Date : 2023-12-16 Ryusei Maeyama, Ryosuke Segawa, Ryo Onodera, Masahiro Hiratsuka, Noriyasu Hirasawa
Nickel (Ni) is a typical hapten in allergic contact dermatitis. However, it has been used in various metal materials due to its usefulness. Although Ni ions induce apoptosis of inflammatory cells and the expression of inflammatory cytokines such as interleukin-8 (IL-8), the effects of the apoptotic pathway on the signaling that induces cytokine production have not been sufficiently clarified. Here
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DON induced DNA damage triggers absence of p53-mediated G2 arrest and apoptosis in IPEC-1 cells Toxicology (IF 4.5) Pub Date : 2023-12-16 Silu Hou, Jingjiao Ma, Yuqiang Cheng, Zhaofei Wang, Guiping Wang, Aiqing Jia, Hengan Wang, Jianhe Sun, Yaxian Yan
Deoxynivalenol (DON) stands among the prevalent mycotoxins, and usually contaminates cereal foods and animal feed, leading to human and animal clinical poisoning symptoms such as abdominal pain, diarrhea, and vomiting. To date, the mechanism of toxicity of DON in different mammalian cells is not fully elucidated. In this study, we explored the detrimental impacts of DON on porcine intestinal epithelial
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A deep-learning approach for identifying prospective chemical hazards Toxicology (IF 4.5) Pub Date : 2023-12-15 Sohaib Habiballah, Lenwood S. Heath, Brad Reisfeld
With the aim of helping to set safe exposure limits for the general population, various techniques have been implemented to conduct risk assessments for chemicals and other environmental stressors; however, none of these tools facilitate the identification of completely new chemicals that are likely hazardous and elicit an adverse biological effect. Here, we detail a novel in silico, deep-learning
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Redox imbalance and inflammation: A link to depression risk in brazilian pesticide-exposed farmers Toxicology (IF 4.5) Pub Date : 2023-12-12 Mariane Magalhães Zanchi, Filomena Marafon, Katiuska Marins, Margarete Dulce Bagatini, Ariane Zamoner
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Exposure to volatile organic compounds induces cardiovascular toxicity that may involve DNA methylation Toxicology (IF 4.5) Pub Date : 2023-12-07 Zhuoyan Li, Jieru Lu, Xuehua Ruan, Yurong Wu, Jianyuan Zhao, Xianting Jiao, Jing Sun, Kun Sun
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ATR induces hepatic lipid metabolism disorder in rats by activating IRE1α/XBP1 signaling pathway Toxicology (IF 4.5) Pub Date : 2023-12-04 Honghao Qian, Yaming Zhao, Yiming Wang, Haotang Zhao, Jianwei Cui, Ziyu Wang, Hui Ye, Xiaoqi Fang, Zhili Ge, Yuezhu Zhang, Lin Ye
Atrazine (ATR) is a widely used herbicide and due to its persistence in environment and bioaccumulation, it can cause harmful impacts on human health. ATR exposure can lead to disorders of lipid metabolism in the liver, but its underlying mechanism is still unclear. 40 eight-week-old rats were given different doses of ATR (0, 0.5, 5 and 50 mg/kg/d) for 90 days. The liver tissue and serum were collected
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Dibromoacetonitrile induced autophagy by mediating the PERK signalling pathway and ROS interaction in HT22 cell Toxicology (IF 4.5) Pub Date : 2023-12-06 Fang Li, Xueyu Zhu, Xinwei Xu, Jie Zhou, Rongzhu Lu, Suhua Wang, Guangwei Xing, Yang Ye