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LINOLEATE-CONTAINING ACYLGLUCOSYLCERAMIDE, ACYLCERAMIDE AND EVENTS ASSOCIATED WITH FORMATION OF THE EPIDERMAL PERMEABILITY BARRIER. Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-11-30 Philip W Wertz
BACKGROUND Linoleate-containing acylglucosylceramide (GLC-CER[EOx], where x = sphingosine (S), dihydrosphingosine (dS), phytosphingosine (P) or 6-hydroxysphingosine (H)) in the viable epidermis serve as the precursors to the linoleate-containing acylceramides (CER[EOx]) in the stratum corneum (SC) and the cornified lipid envelope (CLE), both of which are essential for the barrier function of the skin
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Curcumin as a topical agent in clinical studies. Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-11-26 Ritamaria Di Lorenzo,Federica Forgione,Antonietta Bernardi,Antonia Sacchi,Sonia Laneri,Giovanni Greco
BACKGROUND Curcumin is a polyphenolic compound present in turmeric (Curcuma longa). Curcumin, turmeric powder, and extracts are widely used in traditional Indian medicine and are active ingredients of dietary supplements and cosmeceutical products. The pharmacological properties of curcumin/turmeric as well as the studies performed in vitro, in animal models and in volunteers to assess its effectiveness
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Dill extract preserves dermal elastic fibers network and functionality. Implication of elafin. Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-10-03 Géraldine Aimond,Stéphane Nicolle,Romain Debret,Valérie Oréa,Audrey Josset-Lamaugarny,Jean-François Palierne,Pascal Sommer,Dominique Sigaudo-Roussel,Bérengère Fromy
INTRODUCTION Elastic skin fibers lose their mechanical properties during aging due to enzymatic degradation, lack of maturation or post-translational modifications. Dill extract has been observed to increase elastin protein expression and maturation in a 3D skin model, to improve mechanical properties of skin, to increase elastin protein expression in vascular smooth muscle cells, to preserve aortic
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Human epidermal keratinocytes in culture: a story of multiple recipes for a single cell type. Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-09-16 Yves Poumay,Emilie Faway
BACKGROUND For one half-century, cultures of human epidermal keratinocytes have opened new paths of research in skin biology and dermatology. Either performed with serum and feeder-layer, in serum-free conditions, or in autocrine conditions, cells cultured as monolayers became research materials for basic science and dermatology, as well as a source for grafting, particularly to treat severely burned
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The Skin Barrier and Moisturization: Function, Disruption, and Mechanisms of Repair. Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-09-15 Jeffrey Rajkumar,Neha Chandan,Peter Lio,Vivian Shi
BACKGROUND The anatomic layers of the skin are well-defined, and a functional model of the skin barrier has recently been described. Barrier disruption plays a key role in several skin conditions, and moisturization is recommended as an initial treatment in conditions such as atopic dermatitis. This review aimed to analyze the skin barrier in the context of the function model, with a focus on the mechanisms
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Association of Epidermal Biophysical Properties with Obesity and Its Implications. Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-08-28 Tingting Zhu,Shuyun Yang,Theodora M Mauro,Mao-Qiang Man
BACKGROUND Obesity is a condition defined by an excess amount of body fat, with body mass index (BMI) of 30 and higher. It is associated with a number of other medical conditions, including insulin resistance, diabetes mellitus, and cardiovascular diseases, as well as dyslipidemia, and it is also associated with several cutaneous disorders such as atopic dermatitis, psoriasis, intertriginous dermatitis
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A Prospective Randomized Controlled Pilot Study to Assess the Response and Tolerability of Cold Atmospheric Plasma for Rosacea. Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-07-25 Stella Hofmeyer,Frank Weber,Sandra Gerds,Steffen Emmert,Alexander Thiem
INTRODUCTION Rosacea is a common, facial, chronic inflammatory skin disease. Due to its complex pathogenesis, adequate therapy of rosacea can be challenging. An innovative recent therapeutic tool is cold atmospheric plasma (CAP), which is already established in the treatment of chronic wounds and promising in different other skin diseases. METHODS In a split-face pilot study we investigated dielec
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The Effects of Mucopolysaccharide Polysulfate on Steroid-Induced Tight Junction Barrier Dysfunction in Human Epidermal Keratinocytes and a 3D Skin Model Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-03-25 AKira Koda, Yuko Ishii, Ayu Kashiwagi, Mika Fujikawa, Keisuke kikuchi, Ryota Hashimoto, Yuhki Ueda, Takaaki Doi
Introduction: The long-term use of topical corticosteroids (TCS) is associated with side effects such as skin atrophy and barrier deterioration. Moisturizers, such as mucopolysaccharide polysulfate (MPS), have been reported to prevent relapses in atopic dermatitis (AD) when used in combination with TCS. However, the mechanisms underlying the positive effects of MPS in combination with TCS in AD are
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The epidermal environment’s influence on the dermal environment in response to external stress Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-03-16 Masaki Yoshida, Kyong-Oh Shin, Sora Muraoka, Yerim Choi, Jae-Ho Park, Soo-Hyun Park, Jin-Taek Hwang, Kyungho Park, Yoshikazu Uchida
Introduction: The outermost layer of the skin, the epidermis, is directly exposed to external stress (e.g., irradiation, allergens and chemicals). Changes in epidermal conditions/environment in response to this stress could also influence conditions of the dermis, located directly beneath the epidermis. Yet, whether/how any epidermal environment changes in response to external stress affect dermal
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Skin physiology, mucosal functions and symptoms are modulated by grass pollen and ozone double exposure in allergic patients Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-03-16 Joachim Fluhr, Katarina Stevanovic, Priyanka Joshi, Karl-Christian Bergmann, Leonie S. Herzog, Yasmeen Alwaheed, Shirina Al Sowaidi, Torsten Zuberbier
Introduction: Along with climate changes, we see an increase in allergic symptoms and the number of pollen-allergic patients in many countries. Increased allergic symptoms are associated with an elevated ozone exposure which may be linked by impaired epithelial barrier function. This study aimed to quantify the clinical effect of ozone and pollen double exposure (DE). We tested whether ozone impairs
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Alterations in Epidermal Biophysical Properties in Autistic Children Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-03-14 Bin Wang, You-Dong Li, Zi-Yan Wang, Jia-Qing Zhao, Guo-Qiang Zhang, Mao-Qiang Man
Autism is a neurodevelopmental disorder. Individuals with autism can exhibit multiple neurological symptoms such as deficit in social communication, restricted interests and repetitive behaviors. Recent study showed that murine model of autism displays an increased transepidermal water loss (TEWL) and dry skin. But whether epidermal functions are also altered in children with autism is unknown. In
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Development of an In Vitro Functional Assay to Evaluate the Occlusive Properties of Moisturizers on Dry Skin Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-03-02 Soonjin Hong, Prithwiraj Maitra, Audrey Nguyen, Kuniko Kadoya, Rahul C. Mehta, Elizabeth SelwanLewis
Introduction: Dry skin is a hallmark of impaired skin barrier function. Moisturizers are a mainstay of treatment to help the skin retain moisture, and there is a high consumer demand for effective products. However, the development and optimization of new formulations are hampered due to a lack of reliable efficacy measures using in vitro models. Methods: In this study, a microscopy-based barrier functional
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Evaluation of a novel skin emollient cream on skin lipidome and lipids organization Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-02-08 Carine Jacques, Caroline Dejean, Christian Klose, Emilie Leccia, Sandrine Bessou-Touya, Alain Delarue, Hélène Duplan
Introduction: The stratum corneum (SC) matrix is composed of free fatty acids, cholesterol and ceramides (CERs), which play a key role in the skin barrier function. Changes in the composition and content of skin lipids will affect the function of the skin barrier. The effect of a glycerol/petrolatum-based emollient (G/P-emollient) cream on the lipid profiles of isolated ex vivo human SC and the SC
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Skin care in neonates and infants - a scoping review Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-02-07 Doris Wilborn, Ruhul Amin, Jan Kottner, Ulrike Blume-Peytavi
Background Skin care is a basic, daily activity performed by formal and informal caregivers from birth until end of life. Skin care activities are influenced by different factors as e.g., culture, knowledge, industrial developments and marketing activities. Therefore, various preferences, traditions and behaviours exist worldwide including skin care of neonates and infants. Objective of this scoping
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MAPK/AP-1 signaling pathway is involved in the protection mechanism of bone marrow mesenchymal stem cells-derived exosomes against Ultraviolet-induced photoaging in human dermal fibroblasts Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-02-06
Introduction: The role of bone marrow mesenchymal stem cells derived exosomes (BMSCs-exo) in skin photoaging was explored in human dermal fibroblasts (HDFs). The underlying mechanism was further explored. Methods: HDFs were exposed to UVB irradiation to establish the cell photodamage models. The cell viability, and levels of oxidative stress-related factors were tested. ELISA was done to detect TNF-α
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Permethrin steal effect by unmasked corneocytic keratin in topical therapy of scabies Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-01-30 Luisa Scholz, Claudia Fritz, Julia Chuttke, Adina Eichner, Johannes Wohlrab
Introduction: The use of epicutaneously applied permethrin in the treatment of common scabies is considered to be the first-line therapy. Due to increasing clinical treatment failure, the development of genetic resistance to permethrin in Sarcoptes scabiei var. hominis has been postulated. In addition, metabolic resistance and pharmacokinetic limitations by parasitic digestion and reactive thickening
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Application of topical Sandalore® increases epidermal dermcidin synthesis in organ-cultured human skin ex vivo. Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-01-26
Introduction: Several olfactory receptors (ORs) are expressed in human skin, where they regulate skin pigmentation, barrier function, wound healing, and hair growth. Previously, we found that the selective activation of OR family 2 subfamily AT member 4 (OR2AT4) by the synthetic, sandalwood-like odorant, Sandalore®, differentially stimulates the expression of antimicrobial peptides (AMPs) in human
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Microinjury-Induced Tumor Necrosis Factor-α Surge Stimulates Hair Regeneration in Mice Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-01-24 Guang-Ri Jin, Su Bin Hwang, Hyeon Ju Park, Bog-Hieu Lee, William A. Boisvert
Introduction: Tumor necrosis factor (TNF)-α released after follicular injury such as that caused by plucking plays a role in the activation of hair regeneration. Microneedle (MN) treatment is applied to the scalp to increase permeability and facilitate the delivery of any number of compounds. Because the MN treatment causes injury to the epidermis, albeit minor, we reasoned that this treatment would
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Histamine skin prick tests: from established diagnostic technique to advanced experimental biomarker Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2023-01-09 Dorien Bamps, Katarina Berdon, Hasan Hernández, Rik Schrijvers, Jan de Hoon, KU LUVEN
Introduction Skin prick tests have a long history as diagnostic and pharmacodynamic biomarker. Besides visual assessments of the wheal and flare, objective blood flow measurements using laser Doppler imaging (LDI) and laser speckle contrast imaging (LSCI) have been reported. In light of these advancements, an up-to-date characterization of the histamine-evoked response is worthwhile. Methods A single-center
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A Phase I Study to Evaluate the Safety and Pharmacokinetics of SHR0302 Base Ointment in Healthy Adult Volunteers Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-12-29 Baoping Li, Nanyang Li, Aik Han Goh, Haifeng Cao, Min Wang Irwin, Xunian Tong, Jingjing Wang, Xiaojie Wu, Jing Zhang, Dan Pu
Introduction: SHR0302 is a highly selective JAK1 inhibitor. This study aims to investigate the safety, tolerability, and pharmacokinetics of single- and multiple-dose topical skin application of SHR0302 base ointment in healthy adult subjects. Methods: This phase I clinical trial (registration number: CTR20192188) consisted of two parts. Part 1 was a single-dose ascending study with four dose levels
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Development of an efficient extraction methodology to analyse potential inflammatory biomarkers from sebum Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-12-26 Hemalatha Jayabal, Dan L. Bader, Peter Worsley
Introduction: Proteins, such as cytokines and chemokines, are present in varying concentrations in a range of biofluids, with an important signalling role in maintaining homeostasis. Commercial tapes have been employed to non-invasively collect these potential biomarkers in sebum from the skin surface to examine their concentrations in conditions including acne, atopic dermatitis and pressure ulcers
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Acknowledgement to the Reviewers Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-12-13
Skin Pharmacol Physiol 2022;35:354
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Contents Vol. 35, 2022 Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-12-13
Skin Pharmacol Physiol 2022;35:I–IV
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Trichoscopic diagnosis of structural hair defects in a clinical setting: A Cross-sectional analytical study Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-12-05 Rania Abdel Hay, Khadiga S. Sayed, Wedad Z. Mostafa, Haidy Atef Afifi, Leila Z. Gad, Solwan Ibrahim El-Samanoudy
Background: Trichoscopy is a simple, non-invasive procedure practiced in the diagnosis of a multitude of scalp and hair disorders. Hair shaft abnormalities usually represent a diagnostic challenge to dermatologists. Objectives: To determine the practicality, versatility and value of using the hand-held dermoscope in assessment of hair shaft abnormalities and the diagnosis of different hair/scalp disorders
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Dermal and transdermal macromolecule delivery using enhancer molecules and colloidal carrier systems. Part II: Percutaneous administration of heparin Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-12-01 Jamal Alyoussef Alkrad, Yousif Ali Almalki Ali Almalki, Eman Zmaily Dahmash, Loay Khaled Hassouneh, Reinhard H.H. Neubert
Introduction: Heparin is a commonly used anticoagulant administered either by intravenous or subcutaneous injection for a systemic effect, or topically for the treatment of peripheral vascular disorders. Objective: This study aimed to formulate heparin in non-ionic colloidal carrier systems (CCSs) having enhanced percutaneous absorption for systemic and topical administration. Methods: Five CCSs were
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Free fatty acids induce lipid accumulation, autophagy and apoptosis in human sebocytes Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-11-16 Amir M. Hossini, Xiaoxiao Hou, Tarik Exner, Beatrix Fauler, Jürgen Eberle, Anja Rabien, Evgenia Makrantonaki, Christos C. Zouboulis
Background: A disruption of sebocyte differentiation and lipogenesis has fatal consequences and can cause a wide spectrum of skin diseases, from acne vulgaris to sebaceous carcinoma, however, the relevant molecular mechanisms have not been fully clarified. Objectives: The induction of autophagy and apoptosis in human sebocytes in response to biologically relevant fatty acids was investigated. Methods:
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Topically confined enhancement of cutaneous microcirculation by cold plasma Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-11-09 Thomas Borchardt, Andreas Helmke, Jennifer Ernst, Steffen Emmert, Arndt F. Schilling, Gunther Felmerer, Wolfgang Viöl
Introduction: We aim to explore potentials and modalities of cold atmospheric pressure plasma (CAP) for the subsequent development of therapies targeting an increased perfusion of the lower leg skin tissue. In this study, we addressed the question whether the microcirculation enhancement is restricted to the tissue in direct contact with plasma or if adjacent tissue might also benefit. Methods: A dielectric
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Challenges in noninvasive skin biomarker measurements in daily practice: a longitudinal study on skin surface protein detection by the Transdermal Analysis Patch in pediatric psoriasis Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-10-06 Mirjam J. Schaap, Finola M. Bruins, Noa Johanna Maria van den Brink, Kadri Orro, Hans M.M. Groenewoud, Elke M.G.J. de Jong, Ellen H. van den Bogaard, Marieke M.B. Seyger
Introduction: Skin surface proteins are potential biomarkers in psoriasis and can be measured noninvasively with the Transdermal Analysis Patch (TAP). This study aims to assess markers measured by TAP over time in daily clinical practice, explore their correlation with disease severity in pediatric psoriasis, and compare the TAP and tape stripping detection capability. Methods: In this prospective
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Direct and Indirect Effects of Blue Light Exposure on Skin: A Review of Published Literature Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-08-31 Orawan Suitthimeathegorn, Cheng Yang, Yanyun Ma, Wei Liu
The growing use of electronic devices and other artificial light sources in recent decades has changed the pattern of exposure to blue light (400–500 nm). Although some progress has been made in the study of the biological effects of blue light on the skin, many questions in this field remain unexplored. The aim of this article was to review the currently available evidence on the deleterious effects
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Sinomenine suppressed keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis by regulating lncRNA XIST Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-08-12 Shoubao Xiang, Xing Wu, Yu Xiang
Background: Psoriasis is a chronic inflammatory skin disease. Sinomenine (SIN) has anti-inflammatory and antioxidant effects. Objective: To confirm the anti-inflammatory effects and mechanism of SIN in imiquimod (IMQ)-induced psoriasis-like mouse model and IMQ induced differentiated human keratinocytes (HaCaT) cells. Methods: BALB/c mice were treated with IMQ to construct a psoriasis-like mice model
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Acidic skin care promotes cutaneous microbiome recovery and skin physiology in an acute stratum corneum stress model Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-07-29 Joachim W. Fluhr, Peter Menzel, Rolf Schwarzer, Benjamin Kaestle, Michaela Arens-Corell, Lina Praefke, Nikolai K. Tsankov, Dessyslava G. Nikolaeva, Laurent Misery, Razvigor Darlenski
Introduction: Skin microbiome and skin physiology are important indicators of the epidermal homeostasis status. Stress models can reveal pathological conditions and modulating effects. Here we investigated the cutaneous microbiome in relation to skin physiology after mild tape stripping (TS) without treatment compared to two cosmetic leave-on lotions (pH 5.5 vs. pH 9.3) in 25 healthy volunteers. Methods:
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Expression of Signal Transducer and Activator of Transcription-3 in Androgenetic Alopecia: A case control study Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-06-16 Akmal Saad Hassan, Mohammad Qassim Al-dhoun, Olfat Gamil Shaker, Aya M. AlOrbani
Background: Signal transducer and activator of transcription (STAT)-3 belongs to a group of latent transcription factors phosphorylated and activated by several protein tyrosine kinases, including members of Janus-kinases (JAKs) family. It is has been implicated that the JAK-STAT pathway activation could promote quiescence in the hair cycle, and topical treatment of mouse and human skin with JAK-inhibitors
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Evaluation of an efficient and skin-adherent semisolid sunscreen nanoformulation Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-06-15 Luiza Abrahão Frank, Rafaela Pletsch Gazzi, Adriana Raffin Pohlmann, Silvia Stanisçuaski Guterres, Renata Vidor Contri
Introduction: Sunscreens are substances applied on the skin surface to protect the skin from the harmful effects of UV light. Nanoparticles can increase the retention time of the sunscreen on the skin surface and its efficacy, by acting as physical barriers. The present investigation aimed to prepare and characterize benzophenone-3-loaded lipid core nanocapsules coated with chitosan (CH-LNC) and, after
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Comparison of lipid foam cream and basic cream on epidermal reconstruction in mild atopic eczema Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-06-15 Dorothee Dähnhardt, Stephan Dähnhardt-Pfeiffer, Judith Schulte-Walter, Eckhard Hanisch, Thomas Neubourg, Regina Fölster-Holst
Introduction: Basic therapy is of central importance in the treatment of atopic eczema. Using electron microscopic images, the morphology of epidermal skin barrier and its lipids was investigated after application of a lipid foam cream and basic cream. Methods: Patients with two contralateral comparable atopic eczema (local SCORAD 1-10) on the forearms were tested. Eczema was treated with a lipid foam
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The emerging therapeutic targets for scar management: genetic and epigenetic landscapes Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-06-13 Sara Amjadian, Sharif Moradi, Parvaneh Mohammadi
Wound healing is a complex process including hemostasis, inflammation, proliferation, and remodeling during which an orchestrated array of biological and molecular events occurs to promote skin regeneration. Abnormalities in each step of the wound healing process lead to reparative rather than regenerative responses, thereby driving the formation of cutaneous scar. Patients suffering from scars represent
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Dexamethasone, a synthetic glucocorticoid, induces the activity of androgen receptor in human dermal papilla cells Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-05-13
Psychosocial stress stimulates the secretion of glucocorticoids (GCs), which are stress-related neurohormones. GCs are secreted from hair follicles and promote hair follicle regression by inducing cellular apoptosis. Moreover, the androgen receptor (AR) is abundant in the balding scalp and androgens suppress hair growth by binding to androgen receptor (AR) in androgenetic alopecia (AGA). First, by
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Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells. Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-05-13 Mi Hee Kwack,Ons Ben Hamida,Moon Kyu Kim,Jung Chul Kim,Young Kwan Sung
Psychosocial stress stimulates the secretion of glucocorticoids (GCs), which are stress-related neurohormones. GCs are secreted from hair follicles and promote hair follicle regression by inducing cellular apoptosis. Moreover, the androgen receptor (AR) is abundant in the balding scalp, and androgens suppress hair growth by binding to AR in androgenetic alopecia. First, by using immunofluorescence
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A composite of hepatocyte growth factor and 5α-dihydrotestosterone–gelatin microspheres with adipose-derived stem cells enhances wound healing Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-04-19 Ke Tao, Xiaozhi Bai, Peng Ji, Yue Zhang, Tao Cao, Fu Han, Zhi Zhang, Hao Guan, Dahai Hu
Introduction: Reconstructing sebaceous glands is one goal of functionally healing patients who have suffered severe burns, instead of the simple pursuit of wound closure. Effective regeneration of skin appendages remains a challenge in skin wound management and research. Objective: The aim of this study was to evaluate the differentiation of ADSC into sebaceous glands, and clarified the involvement
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Induction of Radiodermatitis in Nude Mouse Model using Gamma Irradiator IBL 637 Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-04-13
Introduction: Acute radiodermatitis is a common, though severe, side effect of radiotherapy against cancer that may lead to an interruption or even abortion of the radiotherapy. Mouse models provide an excellent tool to study pathomechanisms of a radiation-induced dermatitis as well as to test and develop novel innovative treatment strategies. Objective: The aim of this study is to provide an overview
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Induction of Radiodermatitis in Nude Mouse Model using Gamma Irradiator IBL 637 Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-04-13 Thoralf Bernhardt,Stephan Kriesen,Katrin Manda,Christin Schlie,Rüdiger Panzer,Guido Hildebrandt,Brigitte Vollmar,Steffen Emmert,Lars Boeckmann
Introduction: Acute radiodermatitis is a common, though severe, side effect of radiotherapy against cancer that may lead to an interruption or even abortion of the radiotherapy. Mouse models provide an excellent tool to study pathomechanisms of a radiation-induced dermatitis as well as to test and develop novel innovative treatment strategies. Objective: The aim of this study is to provide an overview
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Correlation of Body Mass Index with Epidermal Biophysical Properties Varies with Gender in Chinese Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-04-04 Li Ye, Qingsong Lai, Si Wen, Xiaohua Wang, Bin Yang, Mao-Qiang Man
Background: Epidermal function is associated with diabetes and renal disease. Whether obesity can reflect the changes in epidermal function is not clear yet. Objective: We assessed here the correlation of epidermal functions with body mass index (BMI) in a large Chinese cohort. Methods and Subjects: A total of 1405 Chinese aged 21 to 96 years old were enrolled in this study. Epidermal functions, including
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Percutaneous egression: What do we know? Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-03-24 Qisi Sun, Caitlin G. Purvis, Sahir N. Iqbal, Veronica K. Emmerich, Steven R. Feldman, Howard Maibach
Background: The process by which drugs leave the bloodstream to enter the skin compartments is important in determining appropriate routes of delivery and developing more efficacious medications. We conducted a general literature review on percutaneous egression mechanisms. Summary: Studies demonstrate that the stratum corneum (SC) is a compartment for systemically delivered drugs. Upon reviewing the
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LncRNA XIST engages in psoriasis via sponging miR-338-5p to regulate keratinocyte proliferation and inflammation Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-03-01 Yitao Wang, Feifei Jiang, Fang Chen, Dapeng Zhang, Jian Wang
Introduction: Psoriasis is an immune-mediated polygenic inflammatory skin disease, keratinocyte proliferation is an important mechanism. The study investigated the role and regulatory relationship between lncRNA XIST and miR-338-5p in psoriatic patients and cell models. Methods: Serum samples were collected from 55 psoriasis patients. HaCaT was recruited for the cell experiments, and induced by M5
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Lateral Dermal Penetration is Dependent on the Lipophilicity of Active Ingredients Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-02-16 Markus Lubda, Maximilian Zander, Andrew Salazar, Harald Kolmar, Jörg von Hagen
Introduction: With its large surface area skin facilitates a topical administration of active ingredients, and thus percutaneous delivery to a specific target site. Due to its high barrier function and different diffusion characteristics skin governs the efficacy of these active ingredients and a bioavailability in the epidermal and dermal tissue. Objective: In order to characterize the vertical and
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RP-18 TLC and Computational Descriptors of Skin Permeability of Sunscreens Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-02-07 Anna W. Sobańska, Elżbieta Brzezińska
Abstract The relationships between the reversed-phase thin layer chromatographic retention parameters obtained on octadecyl-modified silica (RP-18) sorbent for mobile phases containing water and one of six water-miscible organic modifiers (acetone, methanol, acetonitrile, tetrahydrofurane, N,N-dimethylformamide, 1,4-dioxane) and skin permeability coefficients were studied for a group of 21 cosmetic
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Erratum Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-02-07 Jürgen Lademann, Joachim W. Fluhr, Jürgen Lademann, Stanley Shapiro, Howard I. Maibach, Gerhard J. Nohynek, Peter C.M. van de Kerkhof, Hassan Mukhtar, Christian Surber, Joachim W. Fluhr, Michael S. Roberts, Peter M. Elias, Hans F. Merk, Herbé Bachelez, Hachiro Tagami, Edward M. Jackson, H.-C. Korting H.C., Eva Benfeldt, Eva Benfeldt, De Paepe, Inja Bogdan Allemann, Kristien De Paepe, Nihal Ahmad, Christina
Skin Pharmacol Physiol
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Common cosmetic compounds can reduce air pollution-induced oxidative stress and pro-inflammatory response in the skin Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-01-31 Kristýna Hergesell, Kateřina Valentová, Vladimír Velebný, Kateřina Vávrová, Iva Dolečková
Introduction: Constantly increasing air pollution (AP) poses a concern negatively affecting our health including the skin. A typical manifestation of the skin damage induced by AP is its premature aging, irritation, skin barrier impairment, pigmentation disorders and development or exacerbation of various skin diseases. For these reasons, it is crucial to protect the skin from the negative effects
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An exploratory study of the effects of the pH of synthetic urine on skin integrity in healthy participants Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-01-28 Sofoklis Koudounas, Dan L. Bader, David Voegeli
Background: Incontinence-associated dermatitis (IAD) develops from prolonged exposure of skin to urine and/or stool and represents a common complication in older adults, reducing the quality of life. Increased pH is an important etiologic factor of IAD, however, the relationship between urinary pH and skin barrier disruption remains unclear. Objective: To examine the effects of synthetic urine (s-urine)
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Association of sensitive eyes with sensitive skin: A worldwide study of 10,743 subjects Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-01-19 Laurent Misery, Annabelle Reaux-Le Goazigo, Stéphane Morisset, Sophie Séité, Véronique Delvigne, Béatrice Cochener, Charles Taieb
Introduction: Sensitive eyes are commonly reported by patients but there are very few epidemiological studies on this disorder. The aim of this study was the evaluation of the self-reported frequency of sensitive eyes and the association with sensitive skin. Methods: A survey was performed on a representative sample of the population aged more than 18 years in five different countries (Brazil, China
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Current views on non-invasive in vivo determination of physiological parameters of the stratum corneum using confocal Raman microspectroscopy Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2022-01-10 Maxim E. Darvin, Johannes Schleusener, Jürgen Lademann, Chun-Sik Choe
Confocal Raman microspectroscopy is widely used in dermatology and cosmetology for analysis of the concentration of skin components (lipids, natural moisturizing factor molecules, water) and the penetration depth of cosmetic/medical formulations in the human stratum corneum (SC) in vivo. In recent years, it was shown that confocal Raman microspectroscopy can also be used for non-invasive in vivo depth-dependent
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Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2021-12-09 Chao Sun, Shuang-Hai Hu, Bing-Qi Dong, Shan Jiang, Fang Miao, Tie-Chi Lei
Introduction: Although it has been reported that the anti-diabetic drug metformin has multiple extra-hypoglycemic activities, such as anti-oxidation, anti-aging and even anti-tumor, topical metformin also can induce hair regeneration, but the precise mechanism involved in that process is still unclear. Objectives: To assess the effect of metformin on hair growth in a mouse hair follicle reconstitution
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Acknowledgement to the Reviewers Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2021-11-01
Skin Pharmacol Physiol 2021;34:375–376
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Contents Vol. 34, 2021 Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2021-11-01
Skin Pharmacol Physiol 2021;34:I–VI
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Melanogenesis markers expression in premature graying of hair- a cross-sectional study Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2021-10-26 Ranugha PSS, Subbarao V. Madhunapantula, Jayadev B. Betkerur, Venugopal R. Bovilla, Veeranna Shastry
Background: Studies on mice and aging human hair follicles provide compelling evidence that graying of hair results from premature differentiation of Melanocyte stem cells (MeSC) in the niche/bulge. Objective: To analyze whether differentiation of melanocyte stem cells is responsible for premature graying of hair (PGH). Methods: Twenty- five patients of PGH (n=25) attending dermatology department were
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A biomimetic combination of actives enhances skin hydration and barrier function via modulation of gene expression - Results of two double-blind, vehicle-controlled clinical studies Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2021-10-07 Silke Altgilbers, Frank Rippke, Alexander Filbry, Stefanie Conzelmann, Jens-Peter Vietzke, Thorsten Burkhardt, Dörte Segger, Dennis Roggenkamp, Elke Grönniger
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Influence of Janus kinase inhibitors on the neuronal activity as proof-of-concept model for itch Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2021-09-16 Johannes Wohlrab, David Stintzing, Luise Schultz, Konstantin Jügelt, Olaf H.-U. Schroeder
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Skin lesions, skin care and characteristics of pruritus in patients undergoing haemodialysis Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2021-09-14 Rachel Sommer, Sonja Ständer, Matthias Augustin
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In vivo skin penetration, radical protection and structural changes after topical application of a herbal oil cream compared to topical calcipotriol in mild to moderate psoriasis Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2021-08-17 Juergen Lademann, Parvin Mansouri, Ali Nahavandi, Axel Ahlers, Fatemeh Zibakalam-Mofrad, Barbara Brower, Maryam Nahavandi, Frank Feddern, Maxim E. Darvin, Sabine Schanzer, Heike Richter, Martina C. Meinke, Seyed Ahmad Rezaii, Masoumeh Rohaninasab, Susan Farshi, Massimo Iacobelli, Sora Jung
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Use of Cosmetic Products in Real Life by Women with Facial Sensitive Skin: Results from an Exposure Study and Comparison with Controls Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2021-08-13 Emilie Brenaut, Pauline Nezet, Laurent Misery, Cécile Legeas, Alain-Claude Roudot, Anne-Sophie Ficheux
Triggering factors of sensitive skin are supposed to be physical, chemical (cosmetics, water, and pollutants), and occasionally psychological (stress). A recent meta-analysis showed that the most important triggering factor declared by subjects is the use of cosmetics. This study was designed to compare the consumption of cosmetic products in women with sensitive skin and controls. After a dermatological
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The Response and Tolerability of a Novel Cold Atmospheric Plasma Wound Dressing for the Healing of Split Skin Graft Donor Sites: A Controlled Pilot Study Skin Pharmacol. Physiol. (IF 2.7) Pub Date : 2021-08-06 Annika van Welzen, Matti Hoch, Philip Wahl, Frank Weber, Susen Rode, Julia Katharina Tietze, Lars Boeckmann, Steffen Emmert, Alexander Thiem
Introduction: Cold atmospheric plasma (CAP) has positive effects on wound healing and antimicrobial properties. However, an ongoing challenge is the development of specific modes of application for different clinical indications. Objectives: We investigated in a prospective pilot study the response and tolerability of a newly developed CAP wound dressing for the acute healing of split skin graft donor