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Understanding the Unfolded Protein Response (UPR) Pathway: Insights into Neuropsychiatric Disorders and Therapeutic Potentials. Biomol. Ther. (IF 3.7) Pub Date : 2024-2-27 Pitna Kim
The Unfolded Protein Response (UPR) serves as a critical cellular mechanism dedicated to maintaining protein homeostasis, primarily within the endoplasmic reticulum (ER). This pathway diligently responds to a variety of intracellular indicators of ER stress with the objective of reinstating balance by diminishing the accumulation of unfolded proteins, amplifying the ER's folding capacity, and eliminating
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Potential Role of Dietary Salmon Nasal Cartilage Proteoglycan on UVB-Induced Photoaged Skin. Biomol. Ther. (IF 3.7) Pub Date : 2024-02-15 Hae Ran Lee, Seong-Min Hong, Kyohee Cho, Seon Hyeok Kim, Eunji Ko, Eunyoo Lee, Hyun Jin Kim, Se Yeong Jeon, Seon Gil Do, Sun Yeou Kim
New supplements with preventive effects against skin photodamage are receiving increasing attention. This study evaluated the anti-photoaging effects of salmon nasal cartilage proteoglycan (SPG), acting as a functional material for skin health. We administered SPG to in vitro and in vivo models exposed to ultraviolet B (UVB) radiation and assessed its moisturizing and anti-wrinkle effects on dorsal
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AMPK Alchemy: Therapeutic Potentials in Allergy, Aging, and Cancer. Biomol. Ther. (IF 3.7) Pub Date : 2024-02-13 Ram Hari Pokhrel, Suman Acharya, Sunil Mishra, Ye Gu, Umar Manzoor, Jeon-Kyung Kim, Youngjun Park, Jae-Hoon Chang
All cells are equipped with intricate signaling networks to meet the energy demands and respond to the nutrient availability in the body. AMP-activated protein kinase (AMPK) is among the most potent regulators of cellular energy balance. Under ATP -deprived conditions, AMPK phosphorylates substrates, affect various biological processes, such as lipid/glucose metabolism and protein synthesis. These
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Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression. Biomol. Ther. (IF 3.7) Pub Date : 2024-02-01 Heui-Jin Park, Kyuri Kim, Eun-Young Lee, Prima F Hillman, Sang-Jip Nam, Kyung-Min Lim
Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including
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Dimethyl α-Ketoglutarate Promotes the Synthesis of Collagen and Inhibits Metalloproteinases in HaCaT Cells. Biomol. Ther. (IF 3.7) Pub Date : 2024-02-01 Bo-Yeong Yu, Da-Hae Eom, Hyun Woo Kim, Yong-Joo Jeong, Young-Sam Keum
We observed that treatment with dimethyl α-ketoglutarate (DMK) increased the amount of intracellular α-ketoglutarate significantly more than that of α-ketoglutarate in HaCaT cells. DMK also increased the level of intracellular 4-hydroxyproline and promoted the production of collagen in HaCaT cells. In addition, DMK decreased the production of collagenase and elastase and downregulated the expression
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Robinetin Alleviates Metabolic Failure in Liver through Suppression of p300-CD38 Axis. Biomol. Ther. (IF 3.7) Pub Date : 2024-02-01 Ji-Hye Song, Hyo-Jin Kim, Jangho Lee, Seung-Pyo Hong, Min-Yu Chung, Yu-Geun Lee, Jae Ho Park, Hyo-Kyoung Choi, Jin-Taek Hwang
Metabolic abnormalities in the liver are closely associated with diverse metabolic diseases such as non-alcoholic fatty liver disease, type 2 diabetes, and obesity. The aim of this study was to evaluate the ameliorating effect of robinetin (RBN) on the significant pathogenic features of metabolic failure in the liver and to identify the underlying molecular mechanism. RBN significantly decreased triglyceride
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Hydroxychavicol Inhibits In Vitro Osteoclastogenesis via the Suppression of NF-κB Signaling Pathway. Biomol. Ther. (IF 3.7) Pub Date : 2024-02-01 Sirada Srihirun, Satarat Mathithiphark, Chareerut Phruksaniyom, Pitchanun Kongphanich, Wisutthaporn Inthanop, Thanaporn Sriwantana, Salunya Tancharoen, Nathawut Sibmooh, Pornpun Vivithanaporn
Hydroxychavicol, a primary active phenolic compound of betel leaves, previously inhibited bone loss in vivo by stimulating osteogenesis. However, the effect of hydroxychavicol on bone remodeling induced by osteoclasts is unknown. In this study, the anti-osteoclastogenic effects of hydroxychavicol and its mechanism were investigated in receptor activator of nuclear factor kappa-B ligand (RANKL)-induced
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The Anti-Diabetic Pinitol Improves Damaged Fibroblasts. Biomol. Ther. (IF 3.7) Pub Date : 2024-01-04 Ji-Yong Jung, Joong Hyun Shim, Su Hae Cho, Il-Hong Bae, Seung Ha Yang, Jinsick Kim, Hye Won Lim, Dong Wook Shin
Pinitol (3-O-Methyl-D-chiro-inositol) has been reported to possess insulin-like effects and is known as one of the anti-diabetic agents to improve muscle, liver, and endothelial cells. However, the beneficial effects of pinitol on the skin are not well known. Here, we investigated whether pinitol had effects on human dermal fibroblasts (HDFs), and human dermal equivalents (HDEs) irradiated with ultraviolet
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Immunological Mechanisms in Cutaneous Adverse Drug Reactions. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Ai-Young Lee
Adverse drug reactions (ADRs) are an inherent aspect of drug use. While approximately 80% of ADRs are predictable, immune system-mediated ADRs, often unpredictable, are a noteworthy subset. Skin-related ADRs, in particular, are frequently unpredictable. However, the wide spectrum of skin manifestations poses a formidable diagnostic challenge. Comprehending the pathomechanisms underlying ADRs is essential
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Current Development Status of Cytokines for Cancer Immunotherapy. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Kyoung Song
Cytokines influence the overall cancer immune cycle by triggering tumor antigen expression, antigen presenting, immune cell priming and activation, effector immune cell recruitment and infiltration to cancer, and cancer killing in the tumor microenvironment (TME). Therefore, cytokines have been considered potential anti-cancer immunotherapy, and cytokine-based anti-cancer therapies continue to be an
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Anti-Inflammatory Herbal Extracts and Their Drug Discovery Perspective in Atopic Dermatitis. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Jae-Won Lee, Eun-Nam Kim, Gil-Saeng Jeong
Atopic dermatitis (AD) is an allergic disorder characterized by skin inflammation. It is well known that the activation of various inflammatory cells and the generation of inflammatory molecules are closely linked to the development of AD. There is accumulating evidence demonstrating the beneficial effects of herbal extracts (HEs) on the regulation of inflammatory response in both in vitro and in vivo
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Exploring the Potential of Rosemary Derived Compounds (Rosmarinic and Carnosic Acids) as Cancer Therapeutics: Current Knowledge and Future Perspectives. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Fazila Sirajudeen, Lara J Bou Malhab, Yasser Bustanji, Moyad Shahwan, Karem H Alzoubi, Mohammad H Semreen, Jalal Taneera, Waseem El-Huneidi, Eman Abu-Gharbieh
Cancer is a global health challenge with high morbidity and mortality rates. However, conventional cancer treatment methods often have severe side effects and limited success rates. In the last decade, extensive research has been conducted to develop safe, and efficient alternative treatments that do not have the limitations of existing anticancer medicines. Plant-derived compounds have shown promise
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Effects of Corticosterone on Beta-Amyloid-Induced Cell Death in SH-SY5Y Cells. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Bo Kyeong Do, Jung-Hee Jang, Gyu Hwan Park
Alzheimer's disease (AD) is a neurodegenerative disease characterized by neuronal cell death and memory impairment. Corticosterone (CORT) is a glucocorticoid hormone produced by the hypothalamic-pituitary-adrenal axis in response to a stressful condition. Excessive stress and high CORT levels are known to cause neurotoxicity and aggravate various diseases, whereas mild stress and low CORT levels exert
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Rosmarinic Acid Inhibits Ultraviolet B-Mediated Oxidative Damage via the AKT/ERK-NRF2-GSH Pathway In Vitro and In Vivo. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Mei Jing Piao, Pattage Madushan Dilhara Jayatissa Fernando, Kyoung Ah Kang, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Young Ree Kim, Jin Won Hyun
Rosmarinic acid (RA) is a phenolic ester that protects human keratinocytes against oxidative damage induced by ultraviolet B (UVB) exposure, however, the mechanisms underlying its effects remain unclear. This study aimed to elucidate the cell signaling mechanisms that regulate the antioxidant activity of RA and confirm its cyto-protective role. To explore the signaling mechanisms, we used the human
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Doxorubicin Attenuates Free Fatty Acid-Induced Lipid Accumulation via Stimulation of p53 in HepG2 Cells. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Chawon Yun, Sou Hyun Kim, Doyoung Kwon, Mi Ran Byun, Ki Wung Chung, Jaewon Lee, Young-Suk Jung
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of fat in the liver, and there is a global increase in its incidence owing to changes in lifestyle and diet. Recent findings suggest that p53 is involved in the development of non-alcoholic fatty liver disease; however, the association between p53 expression and the disease remains unclear. Doxorubicin, an anticancer
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Licochalcone C Inhibits the Growth of Human Colorectal Cancer HCT116 Cells Resistant to Oxaliplatin. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Seung-On Lee, Sang Hoon Joo, Jin-Young Lee, Ah-Won Kwak, Ki-Taek Kim, Seung-Sik Cho, Goo Yoon, Yung Hyun Choi, Jin Woo Park, Jung-Hyun Shim
Licochalcone C (LCC; PubChem CID:9840805), a chalcone compound originating from the root of Glycyrrhiza inflata, has shown anticancer activity against skin cancer, esophageal squamous cell carcinoma, and oral squamous cell carcinoma. However, the therapeutic potential of LCC in treating colorectal cancer (CRC) and its underlying molecular mechanisms remain unclear. Chemotherapy for CRC is challenging
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Contribution of HSP90 Cleavage to the Cytotoxic Effect of Suberoylanilide Hydroxamic Acid In Vivo and the Involvement of TXNIP in HSP90 Cleavage. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Sangkyu Park, Dongbum Kim, Haiyoung Jung, In Pyo Choi, Hyung-Joo Kwon, Younghee Lee
Heat shock protein (HSP) 90 is expressed in most living organisms, and several client proteins of HSP90 are necessary for cancer cell survival and growth. Previously, we found that HSP90 was cleaved by histone deacetylase (HDAC) inhibitors and proteasome inhibitors, and the cleavage of HSP90 contributes to their cytotoxicity in K562 leukemia cells. In this study, we first established mouse xenograft
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Antiproliferative Activity of Piceamycin by Regulating Alpha-Actinin-4 in Gemcitabine-Resistant Pancreatic Cancer Cells. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Jee-Hyung Lee, Jin Ho Choi, Kyung-Min Lee, Min Woo Lee, Ja-Lok Ku, Dong-Chan Oh, Yern-Hyerk Shin, Dae Hyun Kim, In Rae Cho, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim, Sang Hyub Lee, Sang Kook Lee
Although gemcitabine-based regimens are widely used as an effective treatment for pancreatic cancer, acquired resistance to gemcitabine has become an increasingly common problem. Therefore, a novel therapeutic strategy to treat gemcitabine-resistant pancreatic cancer is urgently required. Piceamycin has been reported to exhibit antiproliferative activity against various cancer cells; however, its underlying
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Effect of Various Pathological Conditions on Nitric Oxide Level and L-Citrulline Uptake in Motor Neuron-Like (NSC-34) Cell Lines. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Shashi Gautam, Sana Latif, Young-Sook Kang
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder that causes progressive paralysis. L-Citrulline is a non-essential neutral amino acid produced by L-arginine via nitric oxide synthase (NOS). According to previous studies, the pathogenesis of ALS entails glutamate toxicity, oxidative stress, protein misfolding, and neurofilament disruption. In addition, L-citrulline prevents neuronal
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Therapeutic Effects of (+)-Afzelechin on Particulate Matter-Induced Pulmonary Injury. Biomol. Ther. (IF 3.7) Pub Date : 2023-12-27 Sanghee Cho, Yun Jin Park, Jong-Sup Bae
Particulate matter (PM) constitutes a hazardous blend of organic and inorganic particles that poses health risks. Inhalation of fine airborne PM with a diameter of ≤ 2.5 μm (PM2.5) can lead to significant lung impairments. (+)-afzelechin (AZC), a natural compound sourced from Bergenia ligulata, boasts a range of attributes, including antioxidant, antimicrobial, anticancer, and cardiovascular effects
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Domperidone Exerts Antitumor Activity in Triple-Negative Breast Cancer Cells by Modulating Reactive Oxygen Species and JAK/STAT3 Signaling. Biomol. Ther. (IF 3.7) Pub Date : 2023-11-01 Rajina Shakya,Mi Ran Byun,Sang Hoon Joo,Kyung-Soo Chun,Joon-Seok Choi
The lack of molecular targets hampers the treatment of triple-negative breast cancer (TNBC). In this study, we determined the cytotoxicity of domperidone, a dopamine D2 receptor (DRD2) antagonist in human TNBC BT-549 and CAL-51 cells. Domperidone inhibited cell growth in a dose- and time-dependent manner. The annexin V/propidium iodide staining showed that domperidone induced apoptosis. The domperidone-induced
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Licochalcone H Targets EGFR and AKT to Suppress the Growth of Oxaliplatin -Sensitive and -Resistant Colorectal Cancer Cells. Biomol. Ther. (IF 3.7) Pub Date : 2023-11-01 Seung-On Lee,Mee-Hyun Lee,Ah-Won Kwak,Jin-Young Lee,Goo Yoon,Sang Hoon Joo,Yung Hyun Choi,Jin Woo Park,Jung-Hyun Shim
Treatment of colorectal cancer (CRC) has always been challenged by the development of resistance. We investigated the antiproliferative activity of licochalcone H (LCH), a regioisomer of licochalcone C derived from the root of Glycyrrhiza inflata, in oxaliplatin (Ox)-sensitive and -resistant CRC cells. LCH significantly inhibited cell viability and colony growth in both Ox-sensitive and Ox-resistant
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Licochalcone D Inhibits Skin Epidermal Cells Transformation through the Regulation of AKT Signaling Pathways. Biomol. Ther. (IF 3.7) Pub Date : 2023-11-01 Sun-Young Hwang,Kwanhwan Wi,Goo Yoon,Cheol-Jung Lee,Soong-In Lee,Jong-Gil Jung,Hyun-Woo Jeong,Jeong-Sang Kim,Chan-Heon Choi,Chang-Su Na,Jung-Hyun Shim,Mee-Hyun Lee
Cell transformation induced by epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) is a critical event in cancer initiation and progression, and understanding the underlying mechanisms is essential for the development of new therapeutic strategies. Licorice extract contains various bioactive compounds, which have been reported to have anticancer and anti-inflammatory effects
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Sex Differences in the Preventive Effect of Cardiovascular and Metabolic Therapeutics on Dementia. Biomol. Ther. (IF 3.7) Pub Date : 2023-11-01 Sun Ah Choi,Hye Jin Jee,Katrina Joy Bormate,Yeonjae Kim,Yi-Sook Jung
Dementia is a clinical syndrome characterized by progressive impairment of cognitive and functional abilities. As currently applied treatments for dementia can only delay the progression of dementia and cannot fundamentally cure it, much attention is being paid to reducing its incidence by preventing the associated risk factors. Cardiovascular and metabolic diseases are well-known risk factors for
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Stimulatory Anticancer Effect of Resveratrol Mediated by G Protein-Coupled Estrogen Receptor in Colorectal Cancer. Biomol. Ther. (IF 3.7) Pub Date : 2023-10-11 Nayun Kim, Junhye Kwon, Ui Sup Shin, Joohee Jung
Colorectal cancer (CRC) is one of the most high-risk cancers; however, it has been suggested that estrogen signaling in CRC could have a protective effect. Therefore, we focused on the function of the G protein-coupled estrogen receptor (GPER) among the estrogen receptors in CRC. In this study, we investigated the therapeutic effect of resveratrol via GPER in CRC (RKO and WiDr) cells, CRC cell-derived
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Effect of Prunetin on Streptozotocin-Induced Diabetic Nephropathy in Rats - a Biochemical and Molecular Approach. Biomol. Ther. (IF 3.7) Pub Date : 2023-10-11 Jose Vinoth Raja Antony Samy, Nirubama Kumar, Sengottuvelu Singaravel, Rajapandiyan Krishnamoorthy, Mohammad A Alshuniaber, Mansour K Gatasheh, Amalan Venkatesan, Vijayakumar Natesan, Sung-Jin Kim
In the modern era, chronic kidney failure due to diabetes has spread across the globe. Prunetin (PRU), a component of herbal medicines, has a broad variety of pharmacological activities; these may help to slow the onset of diabetic kidney disease. The anti-nephropathic effects of PRU have not yet been reported. The present study explored the potential nephroprotective actions of PRU in diabetic rats
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Aquaporin-3 Downregulation in Vitiligo Keratinocytes Increases Oxidative Stress of Melanocytes. Biomol. Ther. (IF 3.7) Pub Date : 2023-10-11 Nan-Hyung Kim, Ha Jung Kim, Ai-Young Lee
Oxidative stress-induced melanocyte apoptosis is linked to the immune system and plays a critical role in the pathogenesis of vitiligo. Aquaporin-3 (AQP3), which is downregulated in vitiligo keratinocytes, regulates intracellular H2O2 accumulation. However, the role of AQP3 in oxidative stress is uncertain in vitiligo. This study investigated the effect of downregulated AQP3 on oxidative stress in
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Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy. Biomol. Ther. (IF 3.7) Pub Date : 2023-8-29 Xiaofeng Dai, Jiale Wu, Lianghui Lu, Yuyu Chen
Cold atmospheric plasma (CAP), a redox modulation tool, is capable of inhibiting a wide spectrum of cancers and has thus been proposed as an emerging onco-therapy. However, with incremental successes consecutively reported on the anticancer efficacy of CAP, no consensus has been made on the types of tumours sensitive to CAP due to the different intrinsic characteristics of the cells and the heterogeneous
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Aerobic Exercise Ameliorates Muscle Atrophy Induced by Methylglyoxal via Increasing Gastrocnemius and Extensor Digitorum Longus Muscle Sensitivity. Biomol. Ther. (IF 3.7) Pub Date : 2023-08-11 Seong-Min Hong,Eun Yoo Lee,Jinho Park,Jiyoun Kim,Sun Yeou Kim
Muscle atrophy is characterized by the loss of muscle function. Many efforts are being made to prevent muscle atrophy, and exercise is an important alternative. Methylglyoxal is a well-known causative agent of metabolic diseases and diabetic complications. This study aimed to evaluate whether methylglyoxal induces muscle atrophy and to evaluate the ameliorative effect of moderate-intensity aerobic
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C-Reactive Protein Signaling Pathways in Tumor Progression. Biomol. Ther. (IF 3.7) Pub Date : 2023-08-11 Eun-Sook Kim,Sun Young Kim,Aree Moon
Many cancers arise from sites of chronic inflammation, which creates an inflammatory microenvironment surrounding the tumor. Inflammatory substances secreted by cells in the inflammatory environment can induce the proliferation and survival of cancer cells, thereby promoting cancer metastasis and angiogenesis. Therefore, it is important to identify the role of inflammatory factors in cancer progression
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Diagnostic Role of Bile Pigment Components in Biliary Tract Cancer. Biomol. Ther. (IF 3.7) Pub Date : 2023-08-10 Keun Soo Ahn,Koo Jeong Kang,Yong Hoon Kim,Tae-Seok Kim,Kwang Bum Cho,Hye Soon Kim,Won-Ki Baek,Seong-Il Suh,Jin-Yi Han
Bile pigment, bilirubin, and biliverdin concentrations may change as a results of biliary tract cancer (BTC) altering the mechanisms of radical oxidation and heme breakdown. We explored whether changes in bile pigment components could help distinguish BTC from benign biliary illness by evaluating alterations in patients with BTC. We collected bile fluid from 15 patients with a common bile duct stone
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A Novel Role of Hyaluronic Acid and Proteoglycan Link Protein 1 (HAPLN1) in Delaying Vascular Endothelial Cell Senescence. Biomol. Ther. (IF 3.7) Pub Date : 2023-08-08 Dan Zhou,Ji Min Jang,Goowon Yang,Hae Chan Ha,Zhicheng Fu,Dae Kyong Kim
Cardiovascular diseases (CVDs) are the most common cardiovascular system disorders. Cellular senescence is a key mechanism associated with dysfunction of aged vascular endothelium. Hyaluronic acid and proteoglycan link protein 1 (HAPLN1) has been known to non-covalently link hyaluronic acid (HA) and proteoglycans (PGs), and forms and stabilizes HAPLN1-containing aggregates as a major component of extracellular
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Novel Effect of Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) on Hair Follicle Cells Proliferation and Hair Growth. Biomol. Ther. (IF 3.7) Pub Date : 2023-08-08 Hae Chan Ha,Dan Zhou,Zhicheng Fu,Moon Jung Back,Ji Min Jang,In Chul Shin,Dae Kyong Kim
Hair loss is a common condition that can have a negative impact on an individual's quality of life. The severe side effects and the low efficacy of current hair loss medications create unmet needs in the field of hair loss treatment. Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1), one of the components of the extracellular matrix, has been shown to play a role in maintaining its integrity. HAPLN1
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Inhaled Volatile Molecules-Responsive TRP Channels as Non-Olfactory Receptors. Biomol. Ther. (IF 3.7) Pub Date : 2023-08-08 Hyungsup Kim,Minwoo Kim,Yongwoo Jang
Generally, odorant molecules are detected by olfactory receptors, which are specialized chemoreceptors expressed in olfactory neurons. Besides odorant molecules, certain volatile molecules can be inhaled through the respiratory tract, often leading to pathophysiological changes in the body. These inhaled molecules mediate cellular signaling through the activation of the Ca2+-permeable transient receptor
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The Effect of γ-Aminobutyric Acid Intake on UVB- Induced Skin Damage in Hairless Mice. Biomol. Ther. (IF 3.7) Pub Date : 2023-08-01 Hairu Zhao, Bomi Park, Min-Jung Kim, Seok-Hyun Hwang, Tae-Jong Kim, Seung-Un Kim, Iksun Kwon, Jae Sung Hwang
The skin, the largest organ in the body, undergoes age-related changes influenced by both intrinsic and extrinsic factors. The primary external factor is photoaging which causes hyperpigmentation, uneven skin surface, deep wrinkles, and markedly enlarged capillaries. In the human dermis, it decreases fibroblast function, resulting in a lack of collagen structure and also decreases keratinocyte function
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Association between LEPR Genotype and Gut Microbiome in Healthy Non-Obese Korean Adults. Biomol. Ther. (IF 3.7) Pub Date : 2023-07-28 Yoon Jung Cha,In Ae Chang,Eun-Heui Jin,Ji Hye Song,Jang Hee Hong,Jin-Gyu Jung,Jung Sunwoo
The LEPR (leptin receptor) genotype is associated with obesity. Gut microbiome composition differs between obese and nonobese adults. However, the impact of LEPR genotype on gut microbiome composition in humans has not yet been studied. In this study, the association between LEPR single nucleotide polymorphism (rs1173100, rs1137101, and rs790419) and the gut microbiome composition in 65 non-obese Korean
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Biased Dopamine D2 Receptors Exhibit Distinct Intracellular Trafficking Properties and ERK Activation in Different Subcellular Domains. Biomol. Ther. (IF 3.7) Pub Date : 2023-07-19 Shujie Wang, Lulu Peng, Kyeong-Man Kim
Biased signaling or functional selectivity refers to the ability of an agonist or receptor to selectively activate a subset of transducers such as G protein and arrestin in the case of G protein-coupled receptors (GPCRs). Although signaling through arrestin has been reported from various GPCRs, only a few studies have examined side-by-side how it differs from signaling via G protein. In this study
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Intermittent Fasting Modulates Immune Response by Generating Tregs via TGF-β Dependent Mechanisms in Obese Mice with Allergic Contact Dermatitis. Biomol. Ther. (IF 3.7) Pub Date : 2023-07-10 Sang-Chul Han,Jung-Il Kang,Youn Kyung Choi,Hye-Jin Boo,Weon-Jong Yoon,Hee-Kyoung Kang,Eun-Sook Yoo
People with obesity maintain low levels of inflammation; therefore, their exposure to foreign antigens can trigger an excessive immune response. In people with obesity or allergic contact dermatitis (ACD), symptoms are exacerbated by a reduction in the number of regulatory T cells (Tregs) and IL-10/TGF-β-modified macrophages (M2 macrophages) at the inflammatory site. Benefits of intermittent fasting
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NLRP3 Inflammasome as Therapeutic Targets in Inflammatory Diseases. Biomol. Ther. (IF 3.7) Pub Date : 2023-07-01 Annamneedi Venkata Prakash,Il-Ho Park,Jun Woo Park,Jae Pil Bae,Geum Seon Lee,Tae Jin Kang
Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR's), which present in the cell memebrane, are suspect the infection through pathogen-associated molecular patterns (PAMP), and activate innate immunity with response to promote inflammation via inflammatory
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Phytoceramide Alleviates the Carrageenan/Kaolin-Induced Arthritic Symptoms by Modulation of Inflammation. Biomol. Ther. (IF 3.7) Pub Date : 2023-06-29 Bongjun Sur,Mijin Kim,Thea Villa,Seikwan Oh
Phytoceramide (Pcer) is found mainly in plants and yeast. It can be neuroprotective and immunostimulatory on various cell types. In this study, the therapeutic effect of Pcer was explored using the carrageenan/kaolin (C/K)-induced arthritis rat model and fibroblast-like synoviocytes (FLS). Pcer treatment (1, 10, and 30 mg/kg/day) were given to the arthritic rats for 6 days after disease induction.
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Niclosamide Inhibits Aortic Valve Interstitial Cell Calcification by Interfering with the GSK-3β/β-Catenin Signaling Pathway. Biomol. Ther. (IF 3.7) Pub Date : 2023-06-27 Radhika Adhikari,Saugat Shiwakoti,Eunmin Kim,Ik Jun Choi,Sin-Hee Park,Ju-Young Ko,Kiyuk Chang,Min-Ho Oak
The most common heart valve disorder is calcific aortic valve stenosis (CAVS), which is characterized by a narrowing of the aortic valve. Treatment with the drug molecule, in addition to surgical and transcatheter valve replacement, is the primary focus of researchers in this field. The purpose of this study is to determine whether niclosamide can reduce calcification in aortic valve interstitial cells
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LKB1/STK11 Tumor Suppressor Reduces Angiogenesis by Directly Interacting with VEGFR2 in Tumorigenesis. Biomol. Ther. (IF 3.7) Pub Date : 2023-06-26 Seung Bae Rho,Hyun Jung Byun,Boh-Ram Kim,Chang Hoon Lee
Cervical tumors represent a prevalent form of cancer affecting women worldwide; current treatment options involve surgery, radiotherapy, and chemotherapy. Angiogenesis, the process of new blood vessel formation, is a crucial factor in cervical tumor growth. The molecular mechanisms underlying the effects of the liver kinase B1 (LKB1/STK11) tumor suppressor protein on tumor angiogenesis have not been
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Nitric Oxide Signal Transduction and Its Role in Skin Sensitization. Biomol. Ther. (IF 3.7) Pub Date : 2023-06-22 Jong Hun Kim,Min Sik Choi
Nitric oxide (NO) is a signaling molecule that plays a crucial role in numerous cellular physiological processes. In the skin, NO is produced by keratinocytes, fibroblasts, endothelial cells, and immune cells and is involved in skin functions such as vasodilation, pigmentation, hair growth, wound healing, and immune responses. NO modulates both innate and adaptive immune responses. As a signaling molecule
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6-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson's Disease Mouse Model. Biomol. Ther. (IF 3.7) Pub Date : 2023-06-20 Eugene Huh, Jin Gyu Choi, Yujin Choi, In Gyoung Ju, Dongjin Noh, Dong-Yun Shin, Dong Hyun Kim, Hi-Joon Park, Myung Sook Oh
Parkinson's disease (PD) which has various pathological mechanisms, recently, it is attracting attention to the mechanism via microbiome-gut-brain axis. 6-Shogaol, a representative compound of ginger, have been known for improving PD phenotypes by reducing neuroinflammatory responses. In the present study, we investigated whether 6-shogaol and ginger attenuate degeneration induced by Proteus mirabilis
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Alisol B 23-Acetate Ameliorates Ovalbumin-Induced Allergic Asthma during Sensitization and Challenge Periods. Biomol. Ther. (IF 3.7) Pub Date : 2023-06-15 Ki-Hyuk Nam,Dong-Soon Im
Rhizome of Alisma orientale has been used as a traditional medicine for treating kidney diseases in East Asian countries. Its inhibitory effects on hypersensitivity responses have been reported for methanol extracts, with alisol B 23-acetate (AB23Ac) being the most active constituent among six terpenes in inhibiting the direct passive Arthus reaction. However, whether AB23Ac has efficacy against allergic
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Searching for Novel Candidate Small Molecules for Ameliorating Idiopathic Pulmonary Fibrosis: a Narrative Review. Biomol. Ther. (IF 3.7) Pub Date : 2023-05-31 Kyung-Il Kim,Rajib Hossain,Xin Li,Hyun Jae Lee,Choong Jae Lee
Idiopathic pulmonary fibrosis (IPF) can be defined as a progressive chronic pulmonary disease showing scarring in the lung parenchyma, thereby resulting in increase in mortality and decrease in the quality of life. The pathophysiologic mechanism of fibrosis in IPF is still unclear. Repetitive microinjuries to alveolar epithelium with genetical predisposition and an abnormal restorative reaction accompanied
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Regulation of the Gene Expression of Airway MUC5AC Mucin through NF-κB Signaling Pathway by Artesunate, an Antimalarial Agent. Biomol. Ther. (IF 3.7) Pub Date : 2023-05-31 Kyung-Il Kim,Rajib Hossain,Jiho Ryu,Hyun Jae Lee,Choong Jae Lee
In this study, artesunate, an antimalarial agent, was investigated for its potential effect on the gene expression of airway MUC5AC mucin. The human pulmonary epithelial NCI-H292 cells were pretreated with artesunate for 30 min and then stimulated with phorbol 12-myristate 13-acetate (PMA), for the following 24 h. The effect of artesunate on PMA-induced nuclear factor kappa B (NF-kB) signaling pathway
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Cremastranone-Derived Homoisoflavanes Suppress the Growth of Breast Cancer Cells via Cell Cycle Arrest and Caspase-Independent Cell Death. Biomol. Ther. (IF 3.7) Pub Date : 2023-05-25 Yeram Choi, Sangkyu Park, Seul Lee, Ha-Eun Shin, Sangil Kwon, Jun-Kyu Choi, Myeong-Heon Lee, Seung-Yong Seo, Younghee Lee
Breast cancer is the most common cancer and a frequent cause of cancer-related deaths among females globally. As therapeutic strategies for breast cancer have limitations, novel chemotherapeutic reagents and treatment strategies are needed. In this study, we investigated the anti-cancer effect of synthetic homoisoflavane derivatives of cremastranone on breast cancer cells. Homoisoflavane derivatives
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3-Deoxysappanchalcone Inhibits Cell Growth of Gefitinib-Resistant Lung Cancer Cells by Simultaneous Targeting of EGFR and MET Kinases. Biomol. Ther. (IF 3.7) Pub Date : 2023-05-16 Jin-Young Lee,Seung-On Lee,Ah-Won Kwak,Seon-Bin Chae,Seung-Sik Cho,Goo Yoon,Ki-Taek Kim,Yung Hyun Choi,Mee-Hyun Lee,Sang Hoon Joo,Jin Woo Park,Jung-Hyun Shim
The mechanistic functions of 3-deoxysappanchalcone (3-DSC), a chalcone compound known to have many pharmacological effects on lung cancer, have not yet been elucidated. In this study, we identified the comprehensive anti-cancer mechanism of 3-DSC, which targets EGFR and MET kinase in drug-resistant lung cancer cells. 3-DSC directly targets both EGFR and MET, thereby inhibiting the growth of drug-resistant
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Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis. Biomol. Ther. (IF 3.7) Pub Date : 2023-05-15 Kyung Hee Jung,Sang Eun Kim,Han Gyeol Go,Yun Ji Lee,Min Seok Park,Soyeon Ko,Beom Seok Han,Young-Chan Yoon,Ye Jin Cho,Pureunchowon Lee,Sang-Ho Lee,Kipyo Kim,Soon-Sun Hong
According to recent evidence, ferroptosis is a major cell death mechanism in the pathogenesis of kidney injury and fibrosis. Despite the renoprotective effects of classical ferroptosis inhibitors, therapeutic approaches targeting kidney ferroptosis remain limited. In this study, we assessed the renoprotective effects of melatonin and zileuton as a novel therapeutic strategy against ferroptosis-mediated
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Liver Kinase B1 Mediates Its Anti-Tumor Function by Binding to the N-Terminus of Malic Enzyme 3. Biomol. Ther. (IF 3.7) Pub Date : 2023-4-25 Seung Bae Rho, Hyun Jung Byun, Boh-Ram Kim, Chang Hoon Lee
Liver kinase B1 (LKB1) is a crucial tumor suppressor involved in various cellular processes, including embryonic development, tumor initiation and progression, cell adhesion, apoptosis, and metabolism. However, the precise mechanisms underlying its functions remain elusive. In this study, we demonstrate that LKB1 interacts directly with malic enzyme 3 (ME3) through the N-terminus of the enzyme and
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Exosomes: Nomenclature, Isolation, and Biological Roles in Liver Diseases. Biomol. Ther. (IF 3.7) Pub Date : 2023-4-25 Seol Hee Park, Eun Kyeong Lee, Joowon Yim, Min Hoo Lee, Eojin Lee, Young-Sun Lee, Wonhyo Seo
The biogenesis and biological roles of extracellular vesicles (EVs) in the progression of liver diseases have attracted considerable attention in recent years. EVs are membrane-bound nanosized vesicles found in different types of body fluids and contain various bioactive materials, including proteins, lipids, nucleic acids, and mitochondrial DNA. Based on their origin and biogenesis, EVs can be classified
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Antigen Delivery Systems: Past, Present, and Future. Biomol. Ther. (IF 3.7) Pub Date : 2023-04-19 Hyun-Jeong Ko,Yeon-Jeong Kim
The COVID-19 pandemic has increased demand for safe and effective vaccines. Research to develop vaccines against diseases including Middle East respiratory syndrome, Ebolavirus, human immunodeficiency virus, and various cancers would also contribute to global well-being. For successful vaccine development, the advancement of technologies such as antigen (Ag) screening, Ag delivery systems and adjuvants
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A Bivalent Inactivated Vaccine Prevents Enterovirus 71 and Coxsackievirus A16 Infections in the Mongolian Gerbil. Biomol. Ther. (IF 3.7) Pub Date : 2023-04-12 Eun-Je Yi, Young-In Kim, Seung-Yeon Kim, Sung Hyun Ahn, Hyoung Jin Lee, Bohyun Suh, Jaelim Yu, Jeehye Park, Yoon Jung Lee, Eunju Jung, Sun-Young Chang
Hand-foot-and-mouth disease (HFMD) is a viral infectious disease that occurs in children under 5 years of age. Its main causes are coxsackievirus (CV) and enterovirus (EV). Since there are no efficient therapeutics for HFMD, vaccines are effective in preventing the disease. To develop broad coverage against CV and EV, the development of a bivalent vaccine form is needed. The Mongolian gerbil is an
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Anti-Fibrotic Effects of DL-Glyceraldehyde in Hepatic Stellate Cells via Activation of ERK-JNK-Caspase-3 Signaling Axis. Biomol. Ther. (IF 3.7) Pub Date : 2023-04-10 Md Samsuzzaman,Sun Yeou Kim
During liver injury, hepatic stellate cells can differentiate into myofibroblast-like structures, which are more susceptible to proliferation, migration, and extracellular matrix generation, leading to liver fibrosis. Anaerobic glycolysis is associated with activated stellate cells and glyceraldehyde (GA) is an inhibitor of glucose metabolism. Therefore, this study aimed to investigate the anti-fibrotic
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Meclofenamate Suppresses MUC5AC Mucin Gene Expression by Regulating the NF-kB Signaling Pathway in Human Pulmonary Mucoepidermoid NCI-H292 Cells. Biomol. Ther. (IF 3.7) Pub Date : 2023-04-07 Jiho Ryu, Kyung-Il Kim, Rajib Hossain, Misoon Lee, Jin Tae Hong, Hyun Jae Lee, Choong Jae Lee
The current study aimed to reveal the potential effect of meclofenamate, a nonsteroidal anti-inflammatory drug, on the gene expression of airway MUC5AC mucin. Human pulmonary mucoepidermoid NCI-H292 cells were pretreated with meclofenamate for 30 min and stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 h. Thereafter, the effect of meclofenamate on the PMAinduced nuclear factor kappa B (NF-kB)
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Chromatographic Determination of the Absolute Configuration in Sanjoinine A That Increases Nitric Oxide Production. Biomol. Ther. (IF 3.7) Pub Date : 2023-04-06 Soohyun Um,Hyeongju Jeong,Joon Soo An,Se Jin Jo,Young Ran Kim,Dong-Chan Oh,Kyuho Moon
A chiral derivatization strategy with phenylglycine methyl ester (PGME) was employed to develop a straightforward method to determine the absolute configurations of N,N-dimethyl amino acids. The PGME derivatives were analyzed using liquid chromatography-mass spectrometry to identify the absolute configurations of various N,N-dimethyl amino acids based on their elution time and order. The established
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Effect of FTY-720 on Pulmonary Fibrosis in Mice via the TGF-β1 Signaling Pathway and Autophagy. Biomol. Ther. (IF 3.7) Pub Date : 2023-04-06 Yuying Jin,Weidong Liu,Ge Gao,Yilan Song,Hanye Liu,Liangchang Li,Jiaxu Zhou,Guanghai Yan,Hong Cui
We investigated whether FTY-720 might have an effect on bleomycin-induced pulmonary fibrosis through inhibiting TGF-β1 pathway, and up-regulating autophagy. The pulmonary fibrosis was induced by bleomycin. FTY-720 (1 mg/kg) drug was intraperitoneally injected into mice. Histological changes and inflammatory factors were observed, and EMT and autophagy protein markers were studied by immunohistochemistry
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Inhibition of Melanosome Transport by Inducing Exon Skipping in Melanophilin. Biomol. Ther. (IF 3.7) Pub Date : 2023-03-27 Jin Young Kim,Seon-Young Han,Kiho Sung,Jeong Yeon Seo,Cheol Hwan Myung,Chan Song Jo,Jee Hoe Yoon,Ji Yun Park,Jae Sung Hwang
Exon skipping is an efficient technique to inhibit specific gene expression induced by a short-sequence peptide nucleic acid (PNA). To date, there has been no study on the effects of PNA on skin pigmentation. In melanocytes, the tripartite complex is responsible for the transport of mature melanosomes from the nucleus to the dendrites. The tripartite complex is composed of Rab27a, Mlph (Melanophilin)
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Ataxia-Telangiectasia Mutated Is Involved in Autolysosome Formation. Biomol. Ther. (IF 3.7) Pub Date : 2023-03-21 Mihwa Hwang,Dong Wha Jun,Bo Ram Song,Hanna Shim,Chang-Hun Lee,Sunshin Kim
Ataxia-telangiectasia mutated (ATM), a master kinase of the DNA damage response (DDR), phosphorylates a multitude of substrates to activate signaling pathways after DNA double-strand breaks (DSBs). ATM inhibitors have been evaluated as anticancer drugs to potentiate the cytotoxicity of DNA damage-based cancer therapy. ATM is also involved in autophagy, a conserved cellular process that maintains homeostasis