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The amelioration effect of antidiabetic agents on cytokine expression in patients with type 2 diabetes mellitus Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-13 Abeer M. Abd El-Hameed, Areej A. Eskandrani, Eman Salah Abdel-Reheim, Adel Abdel Moneim, Wessam Addaleel
Inflammation is a condition that is closely linked to diabetes mellitus type 2 (T2DM), short for T2DM several different antidiabetic medications have been produced to regulate hyperglycemia, with indications that these therapies may have anti-inflammatory effects along with their glucose-lowering efficacy. Thus, this research was planned to explore the impact of antidiabetic agents on the cytokine
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Virtual reality in experiential pharmacy education: A quasi-experimental study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-13 Nora Alkhudair, Fatma Alrayes, Dalal Alsehli, Shahad AlRayes
Extended reality (XR) technologies are an umbrella term for simulated-based learning tools that cover 3-dimensional technologies, including virtual reality (VR), augmented reality (AR), and mixed reality (MR). At King Saud University, first-year pharmacy students are required to experience hospital observational training during the Introductory Pharmacy Practice Experience (IPPE). We aimed to measure
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Community pharmacist intervention in doxycycline self-medication for acne among pregnant women in Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-13 Marwan Alrasheed, Wael Hamdy Mansy, Mohamed Naser Al-Arifi
Self-medication during pregnancy remains a prevalent global phenomenon, with pregnant women often relying on their own judgment to manage symptoms. This study aimed to assess community pharmacist practice regarding self-medication requests for acne treatment in pregnant women within Saudi Arabia. A descriptive, observational cross-sectional study was conducted in Riyadh, Saudi Arabia. Community pharmacists
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Exploring the therapeutic mechanism of potential phytocompounds from Kalanchoe pinnata in the treatment of diabetes mellitus by integrating network pharmacology, molecular docking and simulation approach Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-13 Rekha Y. Halayal, Zabin K. Bagewadi, Nayef Abdulaziz Aldabaan, Ibrahim Ahmed Shaikh, Aejaz Abdullatif Khan
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Synthesis, in silico ADMET prediction analysis, and pharmacological evaluation of sulfonamide derivatives tethered with pyrazole or pyridine as anti-diabetic and anti-Alzheimer's agents Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-12 Nagwa M. Abdelazeem, Wael M. Aboulthana, Ashraf S. Hassan, Abdulrahman A. Almehizia, Ahmed M. Naglah, Hamad M. Alkahtani
Based on previous developments of our research programs in trying to find new compounds with multiple biological targets such as antioxidant, anti-diabetic, anti-Alzheimer's, and anti-arthritic agents. In the context, a novel series of sulfonamide derivatives based on the pyrazole or pyridine moieties –– and were synthesized from amine compounds with sulfonyl chloride derivatives. The structures of
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Estimating implicit and explicit racial and ethnic bias among community pharmacists in Canada Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-11 Fahad Alzahrani, Nancy Waite, Michael Beazely, Martin Cooke
Bias, whether implicit (unconscious) or explicit (conscious), can lead to preferential treatment of specific social groups and antipathy towards others. When healthcare professionals (HCPs), including pharmacists, act on these biases, patient care and health outcomes can be adversely affected. This study aims to estimate implicit and explicit racial/ethnic bias towards Black and Arab people among community
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Investigation of phytochemicals isolated from selected Saudi medicinal plants as natural inhibitors of SARS CoV-2 main protease: In vitro, molecular docking and simulation analysis Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-08 Yousef T.M. Alharbi, Wael M. Abdel-Mageed, Omer A. Basudan, Ramzi A. Mothana, Md Tabish Rehman, Ali A. ElGamal, Ali S. Alqahtani, Omer I. Fantoukh, Mohamed F. AlAjmi
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Clinical pharmacists’ knowledge, attitude, perception, and beliefs about the role of pharmacogenetic testing for genes polymorphisms when prescribing mercaptopurine Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-06 Norah O. Abanmy, Sara A. Alghamdi, Raneem K. Aljudaie, Omar A. Almohammed
Single nucleotide polymorphisms in the gene encoding proteins involved in mercaptopurine metabolism can influence drug efficacy and safety. This study aims to assess clinical pharmacists’ knowledge about mercaptopurine-related genes and their polymorphisms and investigate their attitudes, perceptions, and beliefs about the need for and importance of pharmacogenetic testing for mercaptopurine. A cross-sectional
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Do pharmacists counsel customers on the disposal of unused or expired household medications? A national survey among 1,596 pharmacists in Indonesia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-05 Sofa D. Alfian, Farida Rendrayani, Qisty A. Khoiry, Mochammad A.A. Pratama, Meliana Griselda, Ivan S. Pradipta, Nursiswati Nursiswati, Rizky Abdulah
Pharmacists play a vital role in counseling customers on proper medication disposal, yet their consistency in providing such information is often lacking. This study aimed to assess pharmacists’ awareness of appropriate disposal practices for unused and expired household medications. Additional objectives included evaluating whether pharmacists offer disposal information during counseling, measuring
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Awareness and knowledge of sun exposure and use of sunscreen among adults in Aseer region, Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-05 E, m, a, d, , B, a, h, a, s, h, w, a, n
Excessive sun exposure and inadequate sunscreen use can lead to skin cancer and other harmful effects on the skin, eyes, and immune system. This observational cross-sectional study aimed to assess awareness and knowledge of sun exposure and sunscreen use among adults in the Aseer region, Saudi Arabia. This study also focused on evaluating the risks of skin cancer and participants’ sun-protective attitudes
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Methanol intoxication in the central region of Saudi Arabia: Five case studies Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-05 Sattam A. Alnefaie, Abdulaziz A. Aldlgan, Khalid M. Albakiri, Mohammed A. Kaabi, Ghada M. Alzwen, Sarah S. Al-Otaibi, Fawaz Alasmari
Outbreaks of methanol poisoning have been described in the medical literature worldwide. However, the few outbreaks that have occurred in Saudi Arabia remain undocumented. This is especially noteworthy in light of the fact that Saudi Arabia is among the countries that explicitly prohibit the usage of alcoholic beverages and recreational drugs. Herein, we describe five cases of methanol poisoning in
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An exploration of factors influencing the selection of generic and innovator medicines in Saudi Arabia using an observational cross-sectional study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-05 Othman AlOmeir, Mansour Almuqbil, Asmaa Hussam Alsawadi, Alaa Mohamed Genedy, Ashwag fawaz Almutairi, Hams Talal Alaydaa, Saleh A. Alanazi, Numan Alabdan, Meshal Alshakrah, Rafiulla Gilkaramenthi, Syed Mohammed Basheeruddin Asdaq, Naira Nayeem
Generic medications are cost-effective without compromising therapeutic outcomes. Therefore, the goal of this study was to investigate, using a cross-sectional study design, the factors influencing Saudi Arabian consumers' preferences between innovator and generic medications. This cross-sectional study was carried out in Saudi Arabia using a Google survey form. For data collection, a simple random
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Use of potentially inappropriate medication for elderly patients in tertiary care hospital of Riyadh, Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-01 Saleh A. Alanazi, Abdulrahman Al Amri, Mansour Almuqbil, Abdullah Alroumi, Merna Gamal Mohamed Alahmadi, Joud Obaid Ayesh Alotaibi, May Mohammed Sulaiman Alenazi, Wejdan Hassan Mossad Alahmadi, Alzahraa Hassan Saleh Al Bannay, Shorooq Khaled Ahmad Marai, Safier M. AlKhatham, Sarah Al-kanhal, Syed Mohammed Basheeruddin Asdaq
The elderly population is affected by chronic diseases and lifelong medication. The American Geriatrics Society (AGS) Beers Criteria is a comprehensive approach to medication usage in the older population to reduce potentially inappropriate medication (PIM) use. The purpose of this study was to assess the usage of PIMs in elderly patients upon discharge from tertiary care hospital settings in Riyadh
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Exploring the therapeutic potential of Derris elliptica (Wall.) Benth in Streptozotocin-Induced diabetic Rats: Phytochemical characterization and antidiabetic evaluation Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-28 Rassheda Abd Rahman, Hanish Singh Jayasingh Chellammal, Syed Adnan Ali Shah, Rozaini Mohd Zohdi, Dhani Ramachandran, Hannis Fadzillah Mohsin
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A detailed review of pharmacology of MFN1 (mitofusion-1)-mediated mitochondrial dynamics: Implications for cellular health and diseases Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-28 A, d, e, l, , A, l, g, h, a, m, d, i
The mitochondria are responsible for the production of cellular ATP, the regulation of cytosolic calcium levels, and the organization of numerous apoptotic proteins through the release of cofactors necessary for the activation of caspases. This level of functional adaptability can only be attained by sophisticated structural alignment. The morphology of the mitochondria does not remain unchanged throughout
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The effect of mephedrone on human neuroblastoma and astrocytoma cells Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-28 Ibrahim M. Alanazi, Abdullah R. Alzahrani, Mohammad A. Alsaad, Abdulaziz L. Moqeem, Abdulmohsen M. Hamdi, Mohiuddin M. Taher, David G. Watson, M. Helen Grant
Mephedrone is an illegal drug that is used recreationally. Few studies have been conducted to investigate the mechanisms by which mephedrone is harming cells. In this research, we investigated the effect of mephedrone using toxicology coupled with LC-MS/MS based metabolomics in the two CNS derived cell lines. Methods of assessment such as neutral red (NR) assay, dimethylthiazolyl diphenyltetrazolium
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Team-based learning versus traditional teaching effect on pharmacy Students’ Performance: A systematic review and Meta-Analysis Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-27 Ghazwa B. Korayem, Albandari A. Alghamdi, Ohoud Aljuhani, Delaney Ivy, Alaa A. Alhubaishi, Hadeel Alkofide
Several pharmacy schools have implemented team-based learning (TBL) in their curriculum worldwide. Yet, TBL's effectiveness compared to traditional teaching in improving students’ outcomes in pharmacy education is yet to be assessed collectively. Thus, the aim of this meta-analysis is to compare the performance of pharmacy students following the implementation of team-based learning (TBL) in the pharmacy
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Development of nanoemulgel of 5-Fluorouracil for skin melanoma using glycyrrhizin as a penetration enhancer Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-24 Nimish Gupta, G.D. Gupta, Karan Razdan, Norah A. Albekairi, Abdulrahman Alshammari, Dilpreet Singh
The purpose of this study was to enhance the topical delivery of 5-Fluorouracil (5-FU), a cancer treatment, by developing a nanoemulgel formulation. Glycyrrhizin (GLY), a natural penetration enhancer has been investigated to exhibit synergistic effects with 5-FU in inhibiting melanoma cell proliferation and inducing apoptosis, Hence, GLY, along with suitable lipids was utilized to create an optimized
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Prevalence and antimicrobial susceptibility pattern of methicillin-resistant Staphylococcus aureus (MRSA) at a maternity and children hospital in Saudi Arabia: A cross-sectional study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-24 Hadiah Almutairi, Heyam Albahadel, Abdullah A. Alhifany, Hind Aldalbahi, Faris S. Alnezary, Ibrahim Alqusi, Mugahid A. Mobark, Masaad Saeed Almutairi
Methicillin-resistant (MRSA) pathogens are considered a serious global health threat, leading to increased mortality and antimicrobial resistance. Rates in Saudi Arabia remain high, necessitating continuous surveillance. This study investigates MRSA prevalence and susceptibility at a Saudi maternity and children's hospital. A cross-sectional study was conducted on pediatric (<18 years) and maternal
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Current situation and barriers to women’s leadership in health care education in Saudi Arabia: A cross-sectional study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-21 Ohoud S. Almalki, Ahmed I. Fathelrahman, Osamah M. Alfayez, Ghada A. Bawazeer, Amal Fatani, Yousif A. Asiri
The aims of the current study were to explore the true representation of female academic staff who have advanced to leadership positions in Saudi health academic institutions and to determine the possible barriers to women’s advancement to leadership positions in academia. This was a cross-sectional study conducted between August 2022 and August 2023 using an adapted self-reported online questionnaire
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Physicochemical and biological properties of encapsulated Boesenbergia rotunda extract with different wall materials in enhancing antioxidant, mineralogenic and osteogenic activities of MC3T3-E1 cells Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-20 Safiah Saah, Dalad Siriwan, Piyapat Trisonthi, Sawitree Dueramae
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A content-quality and optimization analysis of YouTube as a source of patient information for bipolar disorder Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-20 Jawza F. Alsabhan, Haya M. Almalag, Norah O. Abanmy, Yara I. Aljadeed, Reema H. Alhassan, Awatif B. Albaker
The goal of this study was to identify and evaluate the use of Arabic YouTube videos on BD as a resource for patient education. A cross-sectional evaluation of YouTube videos as a source of information for patients with BD in Arabic was performed. The study was observational and, because it did not involve human subjects, it followed the STROBE guidelines whenever possible. The quality of the videos
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An analysis of the intention of female pharmacy students to work in community pharmacy settings in Saudi Arabia using the theory of planned behavior Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-18 Ahmed M. Alshehri, Wafa H. Alqahtani, Aljoharah A. Moaili, Yasser S. Almogbel, Ziyad S. Almalki, Abdullah K. Alahmari, Ahmed A. Albassam, Nehad J. Ahmed
This study aimed to determine the intention of female Saudi pharmacy students to work in community pharmacies and the factors associated with this intention. This cross-sectional study was conducted between April 2022 and June 2022 and included female students from pharmacy colleges in Saudi Arabia. The survey was created based on the Theory of Planned Behavior. It included items that measure student
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Exploring the effectiveness of pharmacy curriculum in Saudi Arabia in developing leadership skills among pharmacy students from their perspective: A mixed-methods study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-18 Majid Ali, Aseel Alsreaya, Abdulrahman Alqarzi, Yazeed Alzahrani, Ibrahim Alhomood, Abdulaziz Alruhaimi, Abdulrahman Hijri, Ahmed Mobarki, Mohammed Najie, Mohammed Mashyakhi, Abdullwahab Bajawi
Leadership is an important component of pharmacy education. This study helps identify the strengths and limitations of the pharmacy curriculum in developing leadership skills among pharmacy students in Saudi Arabia and suggest how to improve the curriculum to better prepare them to become effective leaders in the healthcare profession. This study employed a mixed-methods research design with a sequential
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Improvement of comorbid anxiety and depression in patients with migraine treated with injectable preventive calcitonin gene-related peptide antagonists: Review of clinical evidence Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-15 Abubker Omaer, Abdulrazaq Albilali, Reem Bamogaddam, Fares Almutairi, Raghad Alsaif, Osama Almohammadi, Abdullah A Alhifany
Migraine is often associated with depression and anxiety, leading to a diminished quality of life. Calcitonin gene‐related peptide (CGRP) antagonists have shown promise in treating migraines, but their effects on concurrent depression and anxiety have not been clarified. A literature review was conducted on ClinicalTrials.gov, PubMed, Ovid Medline, and EMBASE focusing on phase 3 clinical trials, post-hoc
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New flavonoids with multiple bronchodilator activity pathways from Tephrosia purpurea L. (Pers.) growing in Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-15 Maged S. Abdel-Kader, Abdulaziz S. Saeedan, Najeeb U. Rehman, Hayder M. Faqihi, Gamal A. Soliman
Total extract of () expressed potent bronchodilator effect in isolated Guinea pigs’ tracheal muscles. Fractionation of total extract ( using liquid–liquid technique followed by bronchodilator testing indicated that the activity was trapped to the chloroform (CHCl) soluble fraction. Phytochemical study of the CHCl fraction guided by bronchodilator activity led to the isolation of 7 active flavones of
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NMDA receptor modulation by Esculetin: Investigating behavioral, biochemical and neurochemical effects in schizophrenic mice model Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-15 Iqra Khalid, Uzma Saleem, Bashir Ahmad, Mohammed F. Hawwal, Ramzi A. Mothana
Schizophrenia, a global mental health disorder affecting approximately 1 % of the population, is characterized by neurotransmitter dysregulation, particularly dopamine, serotonin, and glutamate. Current antipsychotic therapies, despite their efficacy, are accompanied by adverse effects, which has motivated researchers to investigate more secure substitutes. This study examines the potential antipsychotic
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Exploring the topic structure and abuse trends of new psychoactive Substance since the 21st century from a bibliometric perspective Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-15 Xiaolong Hou, Jifen Wang, Ying Zhang, Yufan Zhang, Jianyang Shangguan, Ge Qin, Boxu Chen, Zhenjun Jia, Duo qi Xu
Nowadays, NPS abuse are continuing to expand in terms of harm and scope, due to its cheap and easy to manufacture anywhere in the world. This study reviewed articles related to seven heavily abused NPS to analyze the structure and trends of NPS abuse. A total of 2476 articles were retrieved based on the search strategy for bibliometric analysis. A significant trend of research in recent years was the
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Muslim pilgrims’ knowledge, attitudes, and practices regarding complementary and alternative medicine (CAM); a study conducted during Hajj season Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-12 Aljawharah A. Alqathama, Rizwan Ahmad
Complementary and alternative medicine (CAM) has attracted much interest, and its prevalence in both developed and developing countries has increased. During the Hajj season, millions of Muslims from many different countries travel to Makkah for the pilgrimage. In dealing with health issues during the holy season, many pilgrims prefer to self-medicate with traditional remedies instead of visiting medical
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Chemical profile and biological properties of the Piper corcovadense C.DC. essential oil Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-12 Bruno Henrique Fontoura, Ellen Cristina Perin, Ana Paula Buratto, Jucemar Francisco Schreiner, Kamyla Menezes Cavalcante, Sirlei Dias Teixeira, Daiane Manica, Rafael Antônio Narzetti, Gilnei Bruno da Silva, Margarete Dulce Bagatini, Tatiane Luiza Cadorin Oldoni, Solange Teresinha Carpes
The essential oil fromPiper corcovadense D.DC. (EOPc), an important plant belonging to the Piperaceae family, which is commonly found in the northern region of Brazil and poorly explored scientifically, was used in this study. Thus, the EOPc was characterized chemically by Gas Chromatography/Mass Spectrometry (GC/MS) and the antioxidant and antimicrobial activities and their potential effects on cutaneous
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Challenges and insights: Methamphetamine analysis in post-mortem putrefied human tissues in a hot climate Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-11 Ahmed Alasmari, Amani Alhejaili, Hassan Alharbi, Mansour Alzahrani, Torki Zughaibi
The production and distribution of methamphetamine (meth) is often associated with illegal and clandestine laboratories, posing significant challenges for law enforcement and public health efforts. Global concern is growing over meth-related fatalities, as its high potential for abuse and detrimental impact on health make it an important issue in the realm of substance abuse and addiction. This concern
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Optimized Ribociclib nanostructured lipid carrier for the amelioration of skin cancer: Inferences from ex-vivo skin permeation and dermatokinetic studies Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-10 Mohammed F. Aldawsari, Mohammad Azhar Kamal, Mohamed F. Balaha, Talha Jawaid, Mohammed Jafar, Sana Hashmi, Majid Ahmad Ganaie, Aftab Alam
Current research focuses on explicitly developing and evaluating nanostructured lipidic carriers (NLCs) for the chemotherapeutic drug Ribociclib (RCB) via the topical route to surmount the inherent bioavailability shortcomings. The absolute oral bioavailability has not been determined, but using a physiologically based pharmacokinetic model it was predicted that 65.8 % of the standard dose of RCB (600
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Assessing mental health among students in the UAE: A cross-sectional study utilizing the DASS-21 scale Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-10 Samer O. Alalalmeh, Omar E. Hegazi, Moyad Shahwan, Nageeb Hassan, Ghala Rashid Humaid Alnuaimi, Raghd F. Alaila, Ammar Jairoun, Yomna Tariq Hamdi, Mina Thamer Abdullah, Roaa Mohammed Abdullah, Samer H. Zyoud
The escalating worldwide concerns for mental health, significantly amplified by the COVID-19 pandemic, necessitates understanding the impact on vulnerable populations, such as university students. This study aims to investigate the prevalence and implications of depression, anxiety, and stress among university students in the United Arab Emirates (UAE) using the Depression, Anxiety, and Stress Scale-21
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A comprehensive quality control and cost comparison study of branded and generic angiotensin receptor blockers Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-09 Arvind Kumar Sharma, Shruti Rastogi, Faraat Ali, Anuj Prakash Yadav, Ramesh K. Goyal
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Utilizing sinapic acid as an inhibitory antiviral agent against MERS-CoV PLpro Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-08 Mudassar Shahid, Ahmed L. Alaofi, Mushtaq Ahmad Ansari, Sheikh Fayaz Ahmad, Saleh Alsuwayeh, Ehab Taha, Mohammad Raish
Concerns about the social and economic collapse, high mortality rates, and stress on the healthcare system are developing due to the coronavirus onslaught in the form of various species and their variants. In the recent past, infections brought on by coronaviruses severe acute respiratory syndrome coronaviruses (SARS-CoV and SARS-CoV-2) as well as middle east respiratory syndrome coronavirus (MERS-CoV)
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Consensus methodology to investigate the crucial referral criteria to pharmacist-led counseling clinics in Makkah City Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-07 Sarah M. Khayyat
Identifying and prioritizing criteria for referring patients to a counseling clinic managed by hospital pharmacists in the tertiary care setting in Saudi Arabia (SA). A two-phase consensus Delphi methodological approach was adopted in this study. Data was collected from physicians and pharmacists from different specialties working in different hospitals in Makkah City. In Phase 1, semi-structured interviews
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Xanthine oxidase inhibition study of isolated secondary metabolites from Dolichandrone spathacea (Bignoniaceae): In vitro and in silico approach Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-05 Dang-Khoa Nguyen, Ta-Wei Liu, Su-Jung Hsu, Quoc-Dung Tran Huynh, Truc-Ly Thi Duong, Man-Hsiu Chu, Yun-Han Wang, Thanh-Hoa Vo, Ching-Kuo Lee
Xanthine oxidase (XO) has been widely recognized as a pivotal enzyme in developing hyperuricemia, primarily contributing to the excessive production of uric acid during purine metabolism in the liver. One of the standard treatment approaches involves reducing uric acid levels by inhibiting XO activity. In this study, the leaf extract of , traditionally used in folk medicine, was found to inhibit XO
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Establishing competency based internship program through participatory action research in a private pharmacy college in the Eastern Province of Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-04 Luma Ameer, Nousheen Aslam, Sherihan Ghosn, Jenan Al-Matouq, Zahra Al-Mousa, Safyah Alasfour, Manal Suroor, Yousif Hassan Amin
To use Participatory Action Research (PAR) methodology to develop a competency-based training (CBT) program for Bachelor of Pharmacy interns at Mohammed Al-Mana College for Medical Sciences (MACHS), Dammam, Saudi Arabia, based on the International Pharmaceutical Federation (FIP) Global Competency Framework. The MACHS Pharmacy Department Training Unit developed a competency-based training (CBT) framework
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Design, synthesis, molecular docking, and in vitro studies of 2-mercaptoquinazolin-4(3H)-ones as potential anti-breast cancer agents Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-03 Manal A. Alossaimi, Yassine Riadi, Ghaida N. Alnuwaybit, Shadab Md, Huda Mohammed Alkreathy, Engy Elekhnawy, Mohammed H. Geesi, Safar M. Alqahtani, Obaid Afzal
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Preparation and in vivo evaluation of nano sized cubosomal dispersion loaded with Ruta graveolens extracts as a novel approach to reduce asthma-mediated lung inflammation Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-02 Mohammad H. Alyami, Dalia I. Hamdan, Heba M.A. Khalil, Mohamed A.A. Orabi, Nora M. Aborehab, Nada Osama, Mai M. Abdelhafez, Abdulaziz Mohsen Al-Mahallawi, Hamad S. Alyami
Asthma is a chronic disease affecting people of all ages. Asthma medications are associated with adverse effects restricting their long-term usage, demanding newer alternative therapies. This study aimed to investigate the anti-asthmatic properties of extract and its prepared nano-cubosomal dispersion (Ruta-ND). Firstly, the methanolic extract exhibited higher anti-inflammatory activity on Lipopolysaccharide
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The Anti-urolithiatic effect of the roots of Saussurea costus (falc) Lipsch agonist ethylene glycol and magnesium oxide induced urolithiasis in rats Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-02 Naima Mammate, Fatima Ezzahra El Oumari, Hamada Imtara, Salim Belchkar, Ramzi A. Mothana, Hinde E.L. Fatemi, Mohammed Danouche, Sara Er-rahmani, Nabil Boucetta, Omar M. Noman, Mahmoud Tarayrah, Tarik Sqalli Houssaini
Phytotherapy, which involves the use of plant extracts and natural compounds for medicinal purposes, is indeed a promising alternative for managing urinary lithiasis. Many plants have been studied for their potential to prevent and treat kidney stones, and they may offer a more natural and potentially less harmful approach compared to conventional treatments. Additionally, phytotherapy may be more
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Discovery of water-soluble semicarbazide-containing sulfonamide derivatives possessing favorable anti-glaucoma effect in vivo and drug-like properties Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-02 Yingxia Xie, Xiaoyi Wang, Hao Jia, Naying Chu
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Evaluating preceptorship during advanced pharmacy practice experiences in Saudi Arabia: A Cross-Sectional Study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-28 Faris S. Alnezary, Fahad Alzahrani, Yasser Alatawi, Abdullah A. Alhifany
Introduction Doctor of Pharmacy (PharmD) programs offer students’ academic coursework and Advanced Pharmacy Practice Experiences (APPEs). APPEs are crucial for students, providing hands-on training in practice settings and enhancing clinical skills and decision-making abilities. Nevertheless, successful APPEs relies mainly on preceptorship. Hence, this study aims to evaluate preceptorship during APPEs
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Are drug safety measures harmonized? A real-world evidence from three regulatory authorities Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-26 Sadeem Alelayan, Leena Al-Sheikh, Rana Almotawa, Hadeel Alkofide, Thamir Alshammari
Background Risk minimization measures (RMMs) are interventions intended to mitigate or prevent the occurrence of adverse reactions associated with medications. Having consistent measures across regulatory bodies (i.e., the Saudi Food and Drug Authority (SFDA), the United States Food and Drug Administration (US FDA), and the European Medicines Agency (EMA)) benefits medication use and safety and ultimately
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Pattern of dietary supplement use and its psychosocial predictors among females visiting fitness centers in Saudi Arabia: Findings from a cross-sectional study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-26 Abdulkarim F. Alotaibi, Shuaa N. Khdary, Mais A. Alzarzor Alajami, Esraa A. Sambas, Norah A. Aldakhil, Dana Y. Naibulharam, Alaa A. Alsulmi, Fahad D. Alosaimi
Background Establishing a balanced diet is necessary for obtaining the required daily micronutrients and macronutrients. However, the importance of using dietary supplements to complement one's diet is a significant aspect to consider. While studies have reported the prevalence and patterns of dietary supplements in Saudi Arabia, most focused on university students, women in their reproductive life—particularly
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The effect of inhibiting hindbrain A2 noradrenergic neurons by 6-Hydroxydopamine on lipopolysaccharide-treated male rats autistic animal model Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-23 Hussain N. Alhamami, Abdullah M. Albogami, Mohammad M. Algahtani, Mohammed Alqinyah, Wael A. Alanazi, Fawaz Alasmari, Khalid Alhazzani, Ahmed Z. Alanazi, Yasseen A. Alassmrry, Abdullah S. Alhamed
Autism spectrum disorder (ASD) is a complex neurodevelopmental illness that often emerges in early childhood. The incidence of ASD has shown a notable rise in recent years. ASD is defined by deficits in social communication, and presence of rigid and repetitive behaviors and interests. The underlying mechanisms of ASD remain elusive. Multiple studies have documented the presence of neuroinflammation
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Guideline-directed medical therapy in heart failure patients with reduced ejection fraction in Palestine: Retrospective clinical audit study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-22 Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Sa'ed H. Zyoud, Maimona Jairoun
Objectives To assess the characteristics of patients with heart failure with reduced ejection fraction (HFrEF) and heart failure with mid-range ejection fraction (HFmrEF), as well as the current application of guideline-directed medical therapy (GDMT) in Palestine. Methods This retrospective cohort study involved a population of heart failure (HF) patients who visited cardiology clinics at An-Najah
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Synthesis of tetrazole hybridized with thiazole, thiophene or thiadiazole derivatives, molecular modelling and antimicrobial activity Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-20 Matokah M. Abualnaja, Adel I. Alalawy, Omar M. Alatawi, Ali H. Alessa, Ahmad Fawzi Qarah, Alaa M. Alqahtani, Majid A. Bamaga, Nashwa M. El-Metwaly
Background Tetrazole-based derivatives and their electronic structures have displayed interesting antimicrobial activity. Methods The tetrazole-based hybrids linked with thiazole, thiophene and thiadiazole ring systems have been synthesized through various chemical reactions. The computational method DFT/B3LYP has been utilized to calculate their electronic properties. The antimicrobial effectiveness
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Whole-exome sequencing identifies cancer-associated variants of the endo-lysosomal ion transport channels in the Saudi population Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-19 Lama Binobaid, Homood M. As Sobeai, Khalid Alhazzani, Lama AlAbdi, Meshari M. Alwazae, Moureq Alotaibi, John Parrington, Ali Alhoshani
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Assessment of the anti-cancer potential of Ephedra foeminea leaf extract on MDA-MB-231, MCF-7, 4 T1, and MCF-10 breast cancer cell lines: Cytotoxic, apoptotic and oxidative assays Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-19 Samir Abdulkarim Alharbi, Kamal Eldin Ahmed Abdelsalam, Mohammed Asad, Mohammed Alrouji, Monjid Ahmed Ibrahim, Yasir Almuhanna
Ephedra foeminea is traditionally used to treat breast cancer in several Arab countries. Scientific studies have reported different effects of this plant on some cancer cell lines. The current study determined the anti-cancer potential of the methanolic extract of Ephedra foeminea against four different types of breast cancer cell lines in-vitro. The extract was prepared by maceration and phytoconstituents
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Antioxidant and anti-inflammatory activity through inhibition of NF-κB and sEH of some citrus peel and phytoconstituent characteristics Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-14 Yesi Desmiaty, Ni Made Dwi Sandhiutami, Esti Mulatsari, Farah Alida Maziyah, Kartika Rahmadhani, Hanif Omar Zidane Algifari, Fernanda Alif Jantuna
In Indonesia, there are many types of citrus where parts of the fruit, leaves, and peel can be utilized as food, drinks, spices, and medicine. This research aims to determine the phytochemical characteristics, antioxidant activities, and anti-inflammatory activity through inhibition of NF-κB and sEH, and the main phytoconstituents of three types of citrus fruits that are commonly used as herbs in Indonesia
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Protective effects of vanillic acid on letrozole-induced polycystic ovarian syndrome: A comprehensive study in female wistar rats Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-09 Pradnya V Gadhave, Guruprasad V Sutar, Sachin J Sajane, Vivekkumar K. Redasani, Kuntal Das, Dharani Prasad P, Saad Alobid, Ali Ibrahim Almoteer, Syed Imam Rabbani, Farhana Yasmin, Rafiulla Gilkaramenthi, Majidah Abdulrazaq AlAnazi, Haya Jameel Alshamrani, Syed Mohammed Basheeruddin Asdaq
Background Polycystic ovarian syndrome (PCOS) is one of the known causes of anovulatory fertility in the world. Previous research has linked oxidative stress could contribute to PCOS, and vanillic acid has shown antioxidant potential. Hence, the present study evaluated the effect of vanillic acid on letrozole-induced polycystic ovarian syndrome in female rats. Materials and methods PCOS was induced
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Quality of life tools among patients on dialysis: A systematic review Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-14 Mohammad H. Aljawadi, Asim A. Babaeer, Almothanna S Alghamdi, Abdullah M. Alhammad, Mansour S. Almuqbil, Khalid F Alonazi
Introduction The universal increase in obesity and diabetes has increased the chronic kidney disease (CKD) rate. In 2017, almost 800 million individuals suffered from CKD worldwide. Kidney dialysis becomes necessary as the disease progresses. Dialysis negatively impacts CKD patients' quality of life (QoL). It causes several complications that affect patients' physical, social, psychological, and spiritual
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Response Surface Methodology (RSM) approach to formulate and optimize the bilayer combination tablet of Tamsulosin and Finasteride Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-12 Muneeba Akhtar, Muhammad Zaman, Ahsan Zamir Siddiqi, Hasan Ali, Rahima Khan, Muhammad Nadeem Alvi, Muhammad Hammad Butt, Fatma M. El-Demerdash, Dalal Nasser Binjawhar, Amany A. Sayed, Ahmed E. Altyar, Mohamed M. Abdel-Daim
An orally administered bilayer tablet with Tamsulosin (TAM) as the sustained release (SR) and Finasteride (FIN) as immediate release (IR) was manufactured. A response surface methodology was employed to formulate bilayer tablets with individual release layers, i.e., sustained and immediate release (SR and IR). Independent variables selected in both cases comprise hydroxypropyl methylcellulose (HPMC)
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Zerumbone reduces TLR2 stimulation-induced M1 macrophage polarization pattern via upregulation of Nrf-2 expression in murine macrophages Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-11 Marwa Qadri, Zenat Khired, Reem Alaqi, Sandy Elsayed, Abdulaziz Alarifi, Rayan Ahmed, Hussain Alhamami, Amani Khardali, Walaa Hakami
Hyperuricemia contributes significantly to gout arthritis pathogenesis, which promotes urate crystal deposition in the joints and activates joint-resident macrophages and circulating monocytes to initiate a state of inflammatory arthritis. In the joint, macrophages have an immune defense role where the presence of urate crystals results in the inflammatory mediators secretion, inflammatory cells recruitment
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Consumption of aphrodisiac drugs without prescription among men in Saudi Arabia: cross-sectional study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-10 Sameer Hamdy Hafez, Sadeq Abdo Mohammed Alwesabi, Elwaleed Idris Sagiron, Hanan Saad Abdullah Alwadei, Abdalla MohamedAhmed Osman Abdalla, Elsadig Eltaher Hamed ِAbdulrahman, Nahid Khalil Elfaki, Noha Ahmed Mohamed, Mohammed Abdulrahman Alshahrani, Ahmad A. Alshehri, Mohammed Jamaan Alzahrani, Amna Mohammed Idris, Mohamed Gamal Elsehrawey, Mohammad El-Nablaway, Ateya Megahed Ibrahim
Background: The prevalence and patterns of aphrodisiac drug consumption without prescription among men in Saudi Arabia remain underexplored, with limited empirical evidence available. Given the potential health implications and societal considerations, a comprehensive investigation is warranted. Aim: Assess the Prevalence, pattern of use and the associated factors of Aphrodisiac drugs consumption without
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The assessment of liver function test and fertility hormones in Saudi athletes using anabolic androgenic steroids Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-10 Shatha Jambi, Ahmed Mirza, Torki Zughaibi, Haitham Khalil, Anwar Borai
Background A growing number of athletes are using synthetic anabolic–androgenic steroids (AAS), comprised of testosterone and other derivatives, to enhance athletic performance and muscle mass. Over the years, numerous reports elucidated the side effects of the illegal use of AAS, such as infertility, and liver disorders. The effect of AAS on the hepatic and reproductive systems in Saudi athletes has
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Pharmacy practice in hospital settings in GCC countries: Pharmacists’ medication therapy monitoring activities Saudi Pharm. J. (IF 4.1) Pub Date : 2024-01-04 Ahmed H. Al-jedai, Ahmed Y. Mayet, Fowad Khurshid, Mohammed S. Alsultan
Purpose Our study aims to provide an overview of medication therapy monitoring practices carried out by pharmacists in hospitals across the Gulf Cooperation Council (GCC) countries. Methods This is a cross-sectional questionnaire-based study of hospitals located in the GCC. Questions were adopted from the American Society of Health-System Pharmacists (ASHP) national survey. Frequency analyses were