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Microbeads as carriers for Bacillus pumilus: a biofertilizer focus on auxin production J. Microencapsul. (IF 3.9) Pub Date : 2024-03-12 Solange V. Benítez, Rocio Carrasco, Juan D. Giraldo, Mauricio Schoebitz
The study aimed to develop a solid biofertilizer using Bacillus pumilus, focusing on auxin production to enhance plant drought tolerance. Methods involved immobilising B. pumilus in alginate-starch...
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Construction of various lipid carriers to study the transdermal penetration mechanism of sinomenine hydrochloride J. Microencapsul. (IF 3.9) Pub Date : 2024-03-07 Mengyao Cui, Yaqing Li, Jing Li, Nini Jia, Wenxuan Cao, Zhengguang Li, Xiang Li, Xiaoqin Chu
To investigate the transdermal mechanisms and compare the differences in transdermal delivery of Sinomenine hydrochloride (SN) between solid lipid nanoparticles (SLN), liposomes (LS), and nanoemuls...
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Ethosomes: a potential nanovesicular carrier to enhancing the drug delivery against skin barriers J. Microencapsul. (IF 3.9) Pub Date : 2024-03-08 Huma Hameed, Saleha Faheem, Mahtab Ahmad Khan, Anam Hameed, Nelofer Ereej, Hafsa Ihsan
Ethosomes, which are liposomes like structures, mainly composed primarily of ethanol, have attracted considerable attention due to their potential to enhance the drug permeation via skin. The artic...
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Gelatine nanoparticles encapsulating three edible plant extracts as potential nanonutraceutical agents against type 2 diabetes mellitus J. Microencapsul. (IF 3.9) Pub Date : 2024-02-27 Akurange Sujeevi Dammadinna Wickramasinghe, Anoja Priyadarshani Attanayake, Pabasara Kalansuriya
To optimise, and characterise gelatine nanoparticles (GNPs) encapsulating plant extracts and evaluate the glucose-lowering potential.GNPs encapsulating plant extracts were prepared by desolvation m...
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Enhanced in vitro and ex vivo transdermal permeation of microemulsion gel of tapentadol hydrochloride J. Microencapsul. (IF 3.9) Pub Date : 2024-02-27 Nimmathota Madhavi, Heera Battu
Aim of the current study is to develop a microemulsion gel for transdermal delivery of tapentadol hydrochloride. Microemulsion was developed using phase diagram and subjected to assay, globule size...
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Astaxanthin-loaded alginate-chitosan gel beads activate Nrf2 and pro-apoptotic signalling pathways against oxidative stress J. Microencapsul. (IF 3.9) Pub Date : 2024-02-27 Hamieh Goshtasbi, Elaheh Dalir Abdolahinia, Marziyeh Fathi, Ali Movafeghi, Hossein Omidian, Jaleh Barar, Yadollah Omidi
Oxidative stress (OS) plays a crucial role in disease development. Astaxanthin (ATX), a valuable natural compound, may reduce OS and serve as a treatment for diseases like neurodegenerative disorde...
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Spray dried acerola (Malpighia emarginata DC) juice particles to produce phytochemical-rich starch-based edible films J. Microencapsul. (IF 3.9) Pub Date : 2024-02-12 Dayene Nunes Ribeiro, Kátia Cristina Borges, Kátia Nicolau Matsui, Roberta Targino Hoskin
This study aimed to produce spray dried acerola juice microparticles with different protein carriers to be incorporated into edible starch films. The microparticles were evaluated for solids recove...
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Production and investigation of Pickering emulsion stabilised by casein-Qodume Shirazi (Alyssum homolocarpum) seed gum complex particles: gastrointestinal digestion J. Microencapsul. (IF 3.9) Pub Date : 2024-01-17 Atena Modiri-Dovom, Akram Arianfar, Sara Naji-Tabasi, Vahid Hakimzadeh
Recently, there has been growing research interests in designing Pickering emulsions. In this work, Alyssum homolocarpum seed gum (AHSG) and casein protein (CP) nanoparticles (NPs) fabricated as Pi...
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Investigating the effect of wall material and pressure homogenisation on encapsulation parameters and thermal stability in chia seed oil microcapsules J. Microencapsul. (IF 3.9) Pub Date : 2024-01-10 Vishnu Anand, Vikono Ksh, Sujata Vasudev, Manoj Kumar, Charanjit Kaur
To evaluate the effect of different wall material (WM) matrices followed by homogenisation to encapsulate chia seed oil (CSO) using freeze drying technology.CSO was encapsulated using three ratios ...
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Tumour-specific hybrid nanoparticles in therapy of breast cancer J. Microencapsul. (IF 3.9) Pub Date : 2024-01-10 E. Kilicay, E. Erdal, P. Elci, B. Hazer, E. B. Denkbas
In this study, salicylic acid (SA) dopped into poly(3-hydroxybutyrate) (PHB) and prepared nanoparticles (NPs) to increase encapsulation efficiency, anti-cancer activity of caffeic acid (Caff), and ...
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Quality by design endorsed atorvastatin-loaded nanostructured lipid carriers embedded in pH-responsive gel for melanoma J. Microencapsul. (IF 3.9) Pub Date : 2024-01-10 Deepkumar Bagasariya, Kondasingh Charankumar, Saurabh Shah, Paras Famta, Valencia Fernandes, Syed Shahrukh, Dharmendra Kumar Khatri, Shashi Bala Singh, Saurabh Srivastava
Our aim was to repurpose atorvastatin for melanoma by encapsulating in a nanostructured lipid carrier matrix to promote tumour cell internalisation and skin permeation. pH-responsive chitosan gel w...
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A new approach for the treatment of Alzheimer’s disease: insulin-quantum dots J. Microencapsul. (IF 3.9) Pub Date : 2024-01-10 Gamze Camlik, Besa Bilakaya, Yildiz Ozsoy, Ismail Tuncer Degim
The potential use of insulin supplementation for Alzheimer’s Disease (AD) was aimed to investigate and explore CQDs as an alternative delivery system. CQDs were produced by microwave and characteri...
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Synthesis and bioactivity assessment of Coccinia grandis L. extract encapsulated alginate nanoparticles as an antidiabetic drug lead J. Microencapsul. (IF 3.9) Pub Date : 2024-01-10 Nayomi Deshani De Silva, Anoja Priyadarshani Attanayake, Desiree Nedra Karunaratne, Liyanage Dona Ashanti Menuka Arawwawala, Geethi Kaushalya Pamunuwa
This study aimed to prepare, characterise, and evaluate the antidiabetic activity of Coccinia grandis (L.) extracts encapsulated alginate nanoparticles.Alginate nanoparticles were prepared using th...
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Comparison of the radioprotective effects of the liposomal forms of five natural radioprotectants in alleviating the adverse effects of ionising irradiation on human lymphocytes and skin cells in radiotherapy J. Microencapsul. (IF 3.9) Pub Date : 2023-11-09 Ngoc-Duy Pham, Thi-Huynh-Nga Nguyen, Ngoc-Bich-Dao Vu, Thi-Ngoc-Mai Tran, Bao-Ngoc Pham, Hoang-Sinh Le, Kim-Hai Vo, Xuan-Cuong Le, Le-Bao-Ha Tran, Minh-Hiep Nguyen
This study aims to evaluate the radioprotective effects of liposomes encapsulating curcumin (Lip-CUR), silibinin (Lip-SIL), α-tocopherol (Lip-TOC), quercetin (Lip-QUE) and resveratrol (Lip-RES) in ...
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Sodium alginate and chitosan co-modified fucoxanthin liposomes: preparation, bioaccessibility and antioxidant activity J. Microencapsul. (IF 3.9) Pub Date : 2023-11-09 Hongchun Dong, Siyuan Wang, Cong Fu, Yanxiaofan Sun, Tuantuan Wei, Dandan Ren, Qiukuan Wang
To improve the stability of fucoxanthin, fucoxanthin liposomes (L) were prepared by the thin-film ultrasound method, and fucoxanthin liposomes were modified with sodium alginate and chitosan by an ...
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Herpetetrone nanosuspensions enhance drug solubility and bioavailability to improve anti-hepatic fibrosis effects J. Microencapsul. (IF 3.9) Pub Date : 2023-11-09 Yuji Zhong, Lingyu Hang, Fang Wang, Baode Shen, Chengying Shen, Yuye Xue, Haiqiang Jia, Liqiang Wang, Hailong Yuan
The aim of this study was to enhance the dissolution rate and oral bioavailability of herpetetrone (HPT) by preparing nanosuspensions (NSs) and evaluate the changes in its anti-hepatic fibrosis eff...
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Applications of propolis encapsulation in food products J. Microencapsul. (IF 3.9) Pub Date : 2023-11-09 Cristina Jansen-Alves, Laura Martins Fonseca, Fernanda Doring Krumreich, Elessandra Da Rosa Zavareze
Propolis has beneficial health properties attributed to of phenolic compounds. However, its application is limited. Thus, encapsulation protects the bioactive compounds of propolis from degradation...
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Dual drug loaded polypeptide delivery systems for cancer therapy J. Microencapsul. (IF 3.9) Pub Date : 2023-11-09 Natalia Zashikhina, Erik Gandalipov, Apollinariia Dzhuzha, Viktor Korzhikov-Vlakh, Evgenia Korzhikova-Vlakh
The present study was aimed to prepare and examine in vitro novel dual-drug loaded delivery systems. Biodegradable nanoparticles based on poly(L-glutamic acid-co-D-phenylalanine) were used as nanoc...
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Design and evaluations of a nanostructured lipid carrier loaded with dopamine hydrochloride for intranasal bypass drug delivery in Parkinson’s disease J. Microencapsul. (IF 3.9) Pub Date : 2023-11-09 S. L. Neha, Ashwini Kumar Mishra, Laxmi Rani, Shweta Paroha, Hitesh Kumar Dewangan, Pravat Kumar Sahoo
The goal of this study is to optimisation and evaluation of dopamine-loaded NLC (NLC-DOPA) for achieve dopamine concentrations into brain for treatment of Parkinson’s disease which causes progressi...
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Diruthenium(II-III)-ibuprofen-loaded chitosan-based microparticles and nanoparticles systems: encapsulation, characterisation, anticancer activity of the nanoformulations against U87MG human glioma cells J. Microencapsul. (IF 3.9) Pub Date : 2023-09-12 Hanif-Ur- Rehman, Bárbara Fornaciari, Samara R. Alves, Alison Colquhoun, Denise de Oliveira Silva
The aim of this work was to investigate novel formulations containing diruthenium(II-III)-ibuprofen (RuIbp) metallodrug encapsulated into the chitosan (CT) biopolymer. Microparticles (RuIbp/CT MPs,...
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The management of osteoarthritis symptomatology through nanotechnology: a patent review J. Microencapsul. (IF 3.9) Pub Date : 2023-09-12 Mariana Mendonça Santos, Anamaria Mendonça Santos, José Adão Carvalho Nascimento Júnior, Tatianny De Araujo Andrade, Gomathi Rajkumar, Luiza Abrahão Frank, Mairim Russo Serafini
Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delive...
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Polysorbate 80 surface modified PLGA nanoparticles: an in-vitro evaluation of cellular uptake and cytotoxicity on neuro-2a cells J. Microencapsul. (IF 3.9) Pub Date : 2023-08-23 Surbhi Sharma, Shweta Dang
Present study focuses on the development of P80 coated PLGA Nanoparticles loaded with drugs, paroxetine (P80-Par-PLGA-NPs) and clonidine (P80-CLD-PLGA-NPs) for in-vitro evaluation of Cellular Uptak...
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Development, systematic optimisation and biofilm disruption activity of eugenol-based nanosized emulsions stabilised with Tween 80 J. Microencapsul. (IF 3.9) Pub Date : 2023-08-11 Chandra Lekha Putta, Syed Nazrin Ruhina Rahman, Payel Chakraborty, Tamilvanan Shunmugaperumal
The aims of this study were to systematically optimise a formula for eugenol emulsions via face-centered central composite design and to assess the activity against two-different bacterial strains ...
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Tacrolimus loaded nanostructured lipid carriers using Moringa oleifera seed oil: design, optimization and in-vitro evaluations J. Microencapsul. (IF 3.9) Pub Date : 2023-07-05 Rajat Garg, Anuj Garg
The proposed research aims to develop Tacrolimus-loaded nanostructured lipid carriers (TAC-loaded NLCs) to overcome poor aqueous solubility and dissolution rate to enhance its oral absorption. A ce...
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High internal phase Pickering emulsions stabilised by ultrasound-induced soy protein-β-glucan-catechin complex nanoparticles to enhance the stability and bioaccessibility of curcumin J. Microencapsul. (IF 3.9) Pub Date : 2023-06-15 Xutao Chen, Junrong Huang, Linlin Chen, Xiaona Chen, Danxia Su, Bei Jin
Abstract Aims To evaluate the potential applications of soy protein–glucan–catechin (SGC) complexes prepared with different ultrasound times in stabilising high internal phase Pickering emulsion (HIPPE) and delivering curcumin. Methods The SGC complexes were characterised by particle size, morphology, zeta potential, Fourier transform infra-red, and fluorescence spectroscopy. Formation and stability
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Microencapsulation of Bacillus subtilis and oat β-glucan and their application as a synbiotic in fish feed J. Microencapsul. (IF 3.9) Pub Date : 2023-06-08 Angélica Priscila do Carmo Alves, Amanda do Carmo Alves, Rodney Alexandre Ferreira Rodrigues, Brunno da Silva Cerozi, José Eurico Possebon Cyrino
To improve survival during storage and exposure to adverse conditions, Bacillus subtilis was microencapsulated with oat β-glucan by spray-drying technology. The characterisation of the microcapsule...
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Enhancement of ocular anti-glaucomic activity of agomelatine through fabrication of hyaluronic acid modified-elastosomes: formulation, statistical optimisation, in vitro characterisation, histopathological study, and in vivo assessment J. Microencapsul. (IF 3.9) Pub Date : 2023-05-31 Asmaa Ashraf Nemr, Galal Mohamed El-Mahrouk, Hany Abdo Badie
Abstract Aim The aim of this manuscript was to fabricate agomelatine (AGM) loaded elastosomes to improve its corneal permeation and ocular bioavailability. AGM is a biopharmaceutical classification system (BCS) class II with low water solubility and high membrane permeability. It has a potent agonistic action on melatonin receptors, so it is used for glaucoma treatment. Methods Elastosomes were made
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In-vitro and in-vivo evaluation and anti-colitis activity of esculetin-loaded nanostructured lipid carrier decorated with DSPE-MPEG2000 J. Microencapsul. (IF 3.9) Pub Date : 2023-05-31 Feng Shi, Wenxiong Yin, Michael Adu-Frimpong, Xiaoxiao Li, Xiaoli Xia, Weigang Sun, Hao Ji, Elmurat Toreniyazov, Wang Qilong, Xia Cao, Jiangnan Yu, Ximing Xu
Abstract Objective Encapsulation of esculetin into DSPE-MPEG2000 carrier was performed to improve its water solubility and oral bioavailability, as well as enhance its anti-inflammatory effect on a mouse model of ulcerative colitis that was induced with dextran sulphate sodium (DSS). Methods We determined the in-vitro and in-vivo high-performance liquid chromatographic (HPLC) analysis method of esculetin;
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Nanoencapsulation and characterisation of Hypericum perforatum for the treatment of neuropathic pain J. Microencapsul. (IF 3.9) Pub Date : 2023-05-26 Radha Goel, Nitin Kumar, Neelam Singh, Rosaline Mishra
Abstract Aim This work aimed to encapsulate Hypericum perforatum extract (HPE) into nanophytosomes (NPs) and assess the therapeutic efficacy of this nanocarrier in neuropathic pain induced by partial sciatic nerve ligation (PSNL). Methods Hydroalcoholic extract of Hypericum perforatum was prepared and encapsulated into NPs by thin layer hydration method. Particle size, zeta potential, TEM, differential
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Preparation and curing behaviour of microencapsulated curing agents for cold-mixed epoxy asphalt J. Microencapsul. (IF 3.9) Pub Date : 2023-05-25 Qiaoliang Xiong, Juntao Du, Minxin Zhang, Huina Jia, Tianjin Li, Yi Nie
Abstract This study aimed to improve control over the curing behaviour of cold-mixed epoxy asphalt by using a microencapsulated curing agent (2-PZ@PC). Prepared through solvent evaporation, the 2-PZ@PC microcapsules had 2-phenylimidazole as the core material and polycarbonate as the shell material. The research examined the impact of core–shell mass ratio on microcapsule morphology and composition
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The protective effect of N-acetylcysteine against liposome and chitosan-induced cytotoxicity J. Microencapsul. (IF 3.9) Pub Date : 2023-05-19 Hamed Hamedinasab, Ali Hossein Rezayan, Mahmoud Reza Jaafari, Mohammad Mashreghi, Hale Alvandi
Abstract Aim N-acetylcysteine (NAC) is an antioxidant used to moderate liposome and chitosan-induced cell cytotoxicity at their high concentrations. Methods Liposome and chitosan were prepared and characterised. The cytotoxicity effect of liposome with NAC-loaded liposome (liposome-NAC) and chitosan solution with chitosan solution containing NAC (chitosan-NAC) on the A549 cell line was compared. Results
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Intranasal spray of cubosomal tizanidine hydrochloride for brain targeting: in vitro and in vivo characterisation J. Microencapsul. (IF 3.9) Pub Date : 2023-05-17 Hetal Thakkar, Bhumi Modi, Brijesh Patel
Abstract Tizanidine HCl (TH) is used as first-line therapy for the treatment of muscular spasm. The intranasal cubosomal delivery system of TH for site-specific delivery, i.e. CNS was developed. Cubosomes of TH were prepared using glyceryl monooleate (GMO) as a lipid, poloxamer 407 as stabiliser, and ethanol and polyethylene glycol 200 as co-solvent. Optimised cubosomes of TH were characterised for
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Development of taste-masking microcapsules containing azithromycin by fluid bed coating for powder for suspension and in vivo evaluation J. Microencapsul. (IF 3.9) Pub Date : 2023-05-13 Pham-Thi-Phuong Dung, Thanh-Dat Trinh, Quoc-Hoai Nguyen, Huu-Manh Nguyen, Ngoc-Chien Nguyen, Ngoc-Bao Tran, Cao-Son Tran, Thi-Hong-Ngoc Nguyen, Nguyen-Thach Tung
Abstract This research aims to develop bitter taste-masking microcapsules containing azithromycin (AZI) by a simpler and familiar method, fluid-bed coating technology, in comparison with Zithromax®. Cores of microcapsules, AZI microparticles, were prepared by fluid-bed granulation, then taste-masking polymer was covered on by fluid-bed coating technique. Eudragit L100, Eudragit RL100, and ethyl cellulose
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Chitooligosaccharide-catechin conjugate loaded liposome using different stabilising agents: characteristics, stability, and bioactivities J. Microencapsul. (IF 3.9) Pub Date : 2023-05-09 Ajay Mittal, Avtar Singh, Hui Hong, Soottawat Benjakul
Abstract Aim To determine the optimum condition for preparing chitooligosaccharide-catechin conjugate (COS-CAT) liposomes using different stabilising agents. Methods COS-CAT liposomes (0.1–1%, w/v) were prepared using soy phosphatidylcholine (SPC) (50–200 mM) and glycerol or cholesterol (25–100 mg). Encapsulation efficiency (EE), loading capacity (LC), physicochemical characteristics, FTIR spectra
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Encapsulation of Ruta essential oil in chitosan and alginate matrices as an ecological alternative for the control of nematodes J. Microencapsul. (IF 3.9) Pub Date : 2023-04-18 Duvan Fernando Castillo, Rubén Albeiro Sánchez-Andica, Brayan Fernando Enriquez, Jaime Restrepo, Martha Isabel Páez-Melo
Abstract Controlled release formulations of Ruta essential oil obtained by ionic gelation were developed. The presence of rue essential oil in the alginate and chitosan capsules was evidenced by Fourier transform infrared spectroscopy and differential scanning calorimetry. Release studies revealed that in acidic conditions (pH 4.2), the CHS-REO particles reached a Sw of 240% (w/w) in 30 days and 101%
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The anti-cancer effect of resveratrol nano-encapsulated supplements against breast cancer via the regulation of oxidative stress J. Microencapsul. (IF 3.9) Pub Date : 2023-04-18 Soraya Sajadimajd, Faranak Aghaz, Mozafar Khazaei, Assad-Vaisi Raygani
Abstract Aim Several shreds of evidence have supported the growth-inhibitory effect of resveratrol in breast cancer. Owing to the low efficiency, we aimed to fabricate an ACN nanoparticle containing resveratrol to target the proliferation of breast cancer cells. Methods Resveratrol encapsulation was characterized using spectrophotometry, FTIR, and SEM. The cytotoxicity and antioxidant activities of
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Mung bean protein isolate treated with high-intensity pulsed electric field: characteristics and its use for encapsulation of Asian seabass oil J. Microencapsul. (IF 3.9) Pub Date : 2023-04-13 Saqib Gulzar, Mohamed Tagrida, Umesh Patil, Lukai Ma, Bin Zhang, Soottawat Benjakul
Abstract Aim To modify the techno-functional properties of mung bean protein isolate (MBPI) by high-intensity pulsed electric field (HIPEF) treatment and to apply the treated MBPI for encapsulation of Asian seabass oil (ASO). Methods MBPI was prepared using isoelectric precipitation. HIPEF was applied to MBPI solutions at 25 kV/cm with varying pulse numbers (0–400). Physicochemical properties and structure
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Assessment of anti-arthritic activity of lipid matrix encased berberine in rheumatic animal model J. Microencapsul. (IF 3.9) Pub Date : 2023-04-11 Neelu Singh, Amit Kumar Pandey, Ravi Raj Pal, Alka, Poonam Parashar, Priya Singh, Nidhi Mishra, Dinesh Kumar, Ritu Raj, Sukhveer Singh, Shubhini A. Saraf
Abstract The purpose of this study was to evaluate the drug delivery and therapeutic potential of berberine (Br) loaded nanoformulation in rheumatoid arthritis (RA)-induced animal model. The Br-loaded NLCs (nanostructured lipid carriers) were prepared employing melt-emulsification process, and optimised through Box–Behnken design. The prepared NLCs were assessed for in-vitro and in-vivo evaluations
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Nanoencapsulated cordyceps extract enhances collagen synthesis and skin cell regeneration through antioxidation and autophagy J. Microencapsul. (IF 3.9) Pub Date : 2023-04-08 Nawapol Upatcha, Palakorn Kaokaen, Natchadaporn Sorraksa, Ruchee Phonchai, Phongsakorn Kunhorm, Nipha Chaicharoenaudomrung, Parinya Noisa
Abstract Oxidative stress from reactive oxygen species is the main cause of skin ageing. Cordycepin, a bioactive compound of Cordyceps militaris, contains antioxidant activity. This study examined extracellular matrix, antioxidant effect, autophagy activity, and skin regeneration in human dermal fibroblasts (HDFs) under normal and oxidative stress conditions. Slow disintegration was used to create
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Piperine liposome-embedded in hyaluronan hydrogel as an effective platform for prevention of postoperative peritoneal adhesion J. Microencapsul. (IF 3.9) Pub Date : 2023-04-03 Hanieh Karimi, Shahram Rabbani, Delaram Babadi, Simin Dadashzadeh, Azadeh Haeri
Abstract This study aimed to prepare piperine (PIP) loaded liposomes in hyaluronic acid (HA) hydrogel to provide a hybrid superstructure for postoperative adhesion prevention. Liposomes were prepared using thin-film hydration method. The optimised formulation was characterised by size, SEM, TEM, FTIR, encapsulation efficiency (EE)% (w/w), and release pattern. Liposome-in-hydrogel formulation was investigated
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Dry powder formulation of azithromycin for COVID-19 therapeutics J. Microencapsul. (IF 3.9) Pub Date : 2023-03-27 Stefanie Ho Yi Chan, Khalid Sheikh, Mohammed Gulrez Zariwala, Satyanarayana Somavarapu
Abstract Azithromycin is an antibiotic proposed as a treatment for the coronavirus disease 2019 (COVID-19) due to its immunomodulatory activity. The aim of this study is to develop dry powder formulations of azithromycin-loaded poly(lactic-co-glycolic acid) (PLGA) nanocomposite microparticles for pulmonary delivery to improve the low bioavailability of azithromycin. Double emulsion method was used
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Impregnation of polyethylene terephthalate (PET) grafts with BMP-2 loaded functional nanoparticles for reconstruction of anterior cruciate ligament J. Microencapsul. (IF 3.9) Pub Date : 2023-03-21 Zeynep Karahaliloglu, Batur Ercan, Baki Hazer
Abstract Current artificial ligaments based on polyethylene terephthalate (PET) are associated with some disadvantages due to their hydrophobicity and low biocompatibility. In this study, we aimed to modify the surface of PET using polyethylene glycol (PEG)-terminated polystyrene (PS)-linoleic nanoparticles (PLinaS-g-PEG-NPs). We accomplished that BMP-2 in two different concentrations encapsulated
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Development and evaluation of Hedyotis corymbosa (L.) extract containing phytosomes: a preclinical approach for treatment of neuropathic pain in rodent model J. Microencapsul. (IF 3.9) Pub Date : 2023-03-20 Nitin Kumar, Radha Goel, Monika Singh, Neeraj Kant Sharma, Praveen Kumar Gaur, Pradeep Kumar Sharma
Abstract Purpose The study was aimed to encapsulate Hedyotis corymbosa extract (HCE) into phytosomes to improve its therapeutic efficacy in neuropathic pain by enhancing the bioavailability of chief chemical constituent Hedycoryside -A (HCA). Methods For preparing phytosomes complexes (F1, F2, and F3), HCE and phospholipids were reacted in disparate ratio. F2 was chosen to assess its therapeutic efficacy
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Co-delivery of paclitaxel and etoposide prodrug by human serum albumin and PLGA nanoparticles: synergistic cytotoxicity in brain tumour cells J. Microencapsul. (IF 3.9) Pub Date : 2023-03-17 Tatyana Kovshova, Sergey Mantrov, Svetlana Boiko, Julia Malinovskaya, Maria Merkulova, Nadezhda Osipova, Natalia Moiseeva, Mikhail Akimov, Polina Dudina, Ivan Senchikhin, Yulia Ermolenko, Svetlana Gelperina
Abstract The aims of this study were to develop co-delivery systems of paclitaxel (PTX) and etoposide prodrug (4’-O-benzyloxycarbonyl-etoposide, ETP-cbz) based on non-cross-linked human serum albumin (HSA) and poly(lactide-co-glycolide) nanoparticles and to evaluate the synergistic potential of these drugs in vitro. The nanoformulations were prepared by the high-pressure homogenisation technique and
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Construction and evaluation of an antioxidant synergistic system containing vitamin C and vitamin E J. Microencapsul. (IF 3.9) Pub Date : 2023-03-10 Ran Tao, Qianyu Zhang, Jialing Duan, Ran Chen, Liyun Yao, Ruiteng Zhang, Gang Dong, Huali Chen
Abstract Aims The aim of this study is to develop a liposome that could exert unparalleled antioxidant effects. In the present study, a vitamin C (VC)/vitamin E (VE)-co-loaded multivesicular liposome (VCVE-MVL) was constructed. Methods Vitamins were encapsulated in soybean phosphatidylcholine (SPC) and cholesterol (CHO) by multi-emulsification method. The concentration of VC was determined by Fast
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Microencapsulation of β-carotene using barley residue proteins from beer waste as coating material J. Microencapsul. (IF 3.9) Pub Date : 2023-02-28 Ana Cristina Freitas De Oliveira Meira, Larissa Carolina De Morais, Jayne De Abreu Figueiredo, Lizzy Ayra Alcântara Veríssimo, Diego Alvarenga Botrel, Jaime Vilela De Resende
Abstract This study aimed to produce and characterise microparticles produced from barley residue proteins (BRP) enriched with β-carotene. The microparticles were obtained by freeze-drying five emulsion formulations with 0.5% w/w whey protein concentrate and different concentrations of maltodextrin and BRP (0, 1.5, 3.0, 4.5 and 6.0% w/w), with the dispersed phase consisting of corn oil enriched with
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Core-shell micro/nanocapsules: from encapsulation to applications J. Microencapsul. (IF 3.9) Pub Date : 2023-02-28 Eslam Elkalla, Sumera Khizar, Mohamad Tarhini, Noureddine Lebaz, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Abdelhamid Elaissari
Abstract Encapsulation is the way to wrap or coat one substance as a core inside another tiny substance known as a shell at micro and nano scale for protecting the active ingredients from the exterior environment. A lot of active substances, such as flavours, enzymes, drugs, pesticides, vitamins, in addition to catalysts being effectively encapsulated within capsules consisting of different natural
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Impact of formulation design and lyophilisation on the physicochemical characteristics of finasteride nanosystems J. Microencapsul. (IF 3.9) Pub Date : 2023-02-24 Malik Muhammad Irfan, Shefaat Ullah Shah, Kifayat Ullah Shah, Nicolas Anton, Ysia Idoux-Gillet, Guillaume Conzatti, Kifayat Ullah Shah, Elise Perennes, Thierry Vandamme
Abstract The fundamental purpose of this study was to develop a stable lyophilised finasteride nanosystem (FNS-NS) for topical delivery. The FNS-NS was fabricated using an ultrasonication technique. The impact of two different cryoprotectants on the physicochemical characteristics of FNS-NS before and after lyophilisation was thoroughly investigated. The lyophilised FNS-NS had spherical shape with
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Design, development and characterisation of an optimised scaffold to enhance cell proliferation for tissue repair J. Microencapsul. (IF 3.9) Pub Date : 2023-02-23 Subodh Kumar, Chanakya Lahiri, Somya Chaaudhary, Prateek Paul, Yogesh Kumar Verma
Abstract Scaffolds are implanted to spur the regeneration of damaged tissues. The inappropriate construction of scaffolds laden with cells is not efficient. The optimisation of the scaffolds’ constituents is essential for tissue repair. In this study, a scaffold embedded with Raloxifene drug was optimised via Response Surface Methodology (RSM), targeting controlled cell proliferation. The independent
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Microencapsulation of n-tetradecane with poly (methyl methacrylate-co-methacrylic acid) shell by seeded emulsion polymerisation and its thermal energy storage characteristics J. Microencapsul. (IF 3.9) Pub Date : 2023-02-14 U. R. Mahajan, I. Emmanuel, A. Shrinivasa Rao, S. T. Mhaske
Abstract This study aims to enhance the latent heat storage properties of the microcapsules by altering the amount of crosslinking agent from 3 to 20%w/w, the core-to-shell ratio from 1:1 to 2:1, and the amount of initiator from 1 to 3%. The phase change material n-tetradecane (C-14) was microencapsulated by using poly (methyl methacrylate -co- methacrylic acid) as a shell material through an oil by
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Poly(lactic acid)/β-cyclodextrin based nanoparticles bearing ruthenium(II)-arene naproxen complex: preparation and characterisation. Analytical validation for metal determination by microwave-induced plasma optical emission spectrometry J. Microencapsul. (IF 3.9) Pub Date : 2023-02-13 Ruan Reis Nascimento, Julie Pauline Gaitan Tabares, Paulo Neilson Marques dos Anjos, Luana Novaes Santos, Denise de Oliveira Silva, Rodrigo Luis Silva Ribeiro Santos
Abstract The objectives of this work are to develop nanocarrier systems for the Ru(II)-p-cymene naproxen antitumor metallodrug, [Ru(η6-p-cymene)(npx)Cl] or Rupcy, based on polymeric nanoparticles (NPs) composed by the biodegradable poly(lactic acid) (PLA) and the hydrophilic polymerised β-cyclodextrin (PolyCD); to validate an analytical method for determination of Ru incorporated into the metallodrug
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Preparation and characterisation of self-emulsifying drug delivery system (SEDDS) for enhancing oral bioavailability of metformin hydrochloride using hydrophobic ion pairing complexation J. Microencapsul. (IF 3.9) Pub Date : 2023-01-28 Seyedeh Nika Rezvanjou, Mohammad Reza Niavand, Omid Heydari Shayesteh, Ehsan Mehrani Yeganeh, Davood Ahmadi Moghadam, Katayoun Derakhshandeh, Reza Mahjub
Abstract Aim The aim of this study was preparation of a self-emulsifying drug delivery system (SEEDS) containing metformin hydrochloride. Methods Hydrophobic ion paired complexes were prepared by electrostatic interaction between metformin and sodium lauryl sulphate (SLS). The nanodroplets were optimised using two-level full factorial methodology and their morphology were examined. In vitro release
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Synthesis characterisation and neuroprotectivity of Silybum marianum extract loaded chitosan nanoparticles J. Microencapsul. (IF 3.9) Pub Date : 2023-01-25 Hatice Feyzan Ay, Serap Yesilkir-Baydar, Rabia Cakir-Koc
Abstract Aim Silybum marianum extract (SME) possesses neuroprotective potency through its high antioxidant content. We attempted to increase the effectiveness of SME by encapsulating them in chitosan. Neuroprotective potency of SME and SME-loaded chitosan nanoparticles (SME-CNPs) were shown in SH-SY5Y cell line against H2O2-induced oxidative stress. Methods We produced CNPs and SME-CNPs by ionic gelation
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Nanoencapsulation of R-phycoerytrin extracted from Solieria filiformis improves protein stability and enables its biological application as a fluorescent dye J. Microencapsul. (IF 3.9) Pub Date : 2023-01-19 Jéssica Roberta Pereira Martins, Antonia Livânia Linhares de Aguiar, Karina Alexandre Barros Nogueira, Acrisio José Uchôa Bastos Filho, Thais da Silva Moreira, Márjory Lima Holanda Araújo, Claudia Pessoa, Josimar O. Eloy, Ivanildo José da Silva Junior, Raquel Petrilli
Abstract We aimed to encapsulate R-PE to improve its stability for use as a fluorescent probe for cancer cells. Purified R-PE from the algae Solieria filiformis was encapsulated in polymeric nanoparticles using PCL. Nanoparticles were characterised and R-PE release was evaluated. Also, cellular uptake using breast and prostate cancer cells were performed. Nanoparticles presented nanometric particle
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Polymer drug conjugates containing memantine, tacrine and cinnamic acid: promising nanotherapeutics for the treatment of Alzheimer’s disease J. Microencapsul. (IF 3.9) Pub Date : 2023-01-19 Tobeka Naki, William Morwa Reagile Matshe, Mohammed Olusegun Balogun, Suprakas Sinha Ray, Samuel Ayodele Egieyeh, Blessing Atim Aderibigbe
Abstract Aim To prepare polymer-drug conjugates containing a combination of memantine, tacrine, and E)-N-(3-aminopropyl)cinnamide, promising therapeutics for the treatment of neurodegenerative disorders. Methods The conjugates were characterised by 1HNMR, particle size analysis, SEM, LC-MS, TEM/EDX, and XRD, followed by in vitro anti-acetylcholinesterase and drug release studies. Results 1H NMR analysis
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L-Ascorbic acid and phosphatidylcholine complex vesicles: formation and elucidation of their biological activities, and their molecular interactions J. Microencapsul. (IF 3.9) Pub Date : 2022-12-28 Thapakorn Tree-Udom, Chalermrat Simavong, Prapasiri Phetklung, Kanjanaporn Chompoonuch, Sagaw Prateepchinda, Supatchaya Jaemsai, Andrew William King, Oraphan King
Abstract The aim is to prepare, characterise, and evaluate the biological activities and key molecular interactions of L-ascorbic acid and phosphatidylcholine (PC-AA) complex vesicles. PC-AA complexes were prepared and characterised using DLS, TEM, FTIR, UV-Vis, in-vitro release, bioactivities, and cytotoxicity. The key interactions of the AA with the PC were studied with MD simulations. PC-AA complex
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Photoprotective effect of solid lipid nanoparticles of rutin against UVB radiation damage on skin biopsies and tissue-engineered skin J. Microencapsul. (IF 3.9) Pub Date : 2022-12-20 Rodrigo Molina Martins, Silvia de Siqueira Martins, Gustavo Luis Ferreira Barbosa, Maria José Vieira Fonseca, Patrick J. Rochette, Véronique J. Moulin, Luis Alexandre Pedro de Freitas
Abstract Solid lipid nanoparticles (SLNs) containing rutin were prepared to enhance their photochemopreventive effect on the skin. SLNs were produced by the hot melt microemulsion technique. Two 3D skin models: ex vivo skin explants and 3D tissue engineering skin were used to evaluate the photochemopreventive effect of topical formulations containing rutin SLNs, against ultraviolet B (UVB) radiation
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The preparation and characterisation of tasteless core-shell clarithromycin microcapsules J. Microencapsul. (IF 3.9) Pub Date : 2022-12-15 Yu Fu, Yunjing Zhu, Xue Liang, Yihan Kong, Xiaolin Wang, Anan Zhang, Zhiqing Zhao, Jingxin Gou, Yanjiao Wang, Tian Yin, Yu Zhang, Haibing He, Xing Tang
Abstract This study aims to fabricate core-shell clarithromycin (CAM) microcapsules to cover up the bitter taste of CAM by spray drying with aqueous polymer dispersion. Water dispersion of Eudragit EPO and Surelease® were innovatively used to encapsulate CAM into microcapsules via a one-step spray-drying method. The inlet air temperature, airflow rate, CAM-polymer ratio, and particle size of CAM were
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Formulation and characterisation of Azadirachta indica nanobiopesticides for ecofriendly control of wheat pest Tribolium castaneum and Rhyzopertha dominica J. Microencapsul. (IF 3.9) Pub Date : 2022-12-15 Humaira Iqbal, Nazish Jahan, Khalil-ur-Rahman, Saba Jamil
Abstract This study aimed to formulate the green, sustainable, and ecofriendly nanobiopesticides of Azadirachta indica with enhanced pest control efficacy. Nanoprecipitation method was used for the development of nanobiopesticides. Optimisation was done by response surface methodology. Nanoformulations were characterised by zetasizer, scanning electron microscopy, energy dispersive x-ray spectroscopy
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Organogel mediated co-delivery of nisin and 5-fluorouracil: a synergistic approach against skin cancer J. Microencapsul. (IF 3.9) Pub Date : 2022-12-06 Jasleen Kaur, Kaisar Raza, Simran Preet
Abstract Aim The present study aimed to develop topical combinatorial therapy of nisin and 5-fluorouracil in a single nanosized formulation against skin cancer. Methods Nisin and 5-fluorouracil were encapsulated in an organogel system (NF-OG) and investigated for morphology, physicochemical properties, cytotoxicity, encapsulation and release. NF-OG was evaluated against DMBA/TPA murine skin cancer