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Corrigendum to “Emerging strategy for the treatment of urothelial carcinoma: Advances in antibody-drug conjugates combination therapy” Biomed. Pharmacother. 171 (2024) 116152 Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-14 Xiangyun You, Chunming Zhu, Puguang Yu, Xia Wang, Yibing Wang, Jiahe Wang, Junfeng Yu, Kefeng Wang
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Therapeutic potential of Angelica sinensis in addressing organ fibrosis: A comprehensive review Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-14 Xiaodong Zhi, Chunzhen Ren, Qianrong Li, Huaqing Xi, Dong Li, Qilin Chen, Xinfang Lv, Xiang Gao, Xue Wu, Chunling Wang, Bing Jiang, Zhongnan Mao, Hugang Jiang, Kai Liu, Xinke Zhao, Yingdong Li
Fibrosis-related diseases (FRD) include conditions like myocardial fibrosis, pulmonary fibrosis, hepatic fibrosis, renal fibrosis, and others. The impact of fibrosis can be severe, causing organ dysfunction, reduced functionality, and even organ failure, leading to significant health issues. Currently, there is a lack of effective modern anti-fibrosis drugs in clinical practice. However, Chinese medicine
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Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-14 Yiwei Zhou, Yuhan Huang, Wei Ye, Zijie Chen, Zhengzhong Yuan
Depression is a common mental health disorder, and in recent years, the incidence of various forms of depression has been on the rise. Most medications for depression are highly dependency-inducing and can lead to relapse upon discontinuation. Therefore, novel treatment modalities and therapeutic targets are urgently required. Traditional Chinese medicine (TCM) offers advantages in the treatment of
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Painful diabetic neuropathy: The role of ion channels Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-14 Qi Wang, Yifei Ye, Linghui Yang, Lifan Xiao, Jin Liu, Wensheng Zhang, Guizhi Du
Painful diabetic neuropathy (PDN) is a common chronic complication of diabetes that causes neuropathic pain and negatively affects the quality of life. The management of PDN is far from satisfactory. At present, interventions are primarily focused on symptomatic treatment. Ion channel disorders are a major cause of PDN, and a complete understanding of their roles and mechanisms may provide better options
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Tangshen formula targets the gut microbiota to treat non-alcoholic fatty liver disease in HFD mice: A 16S rRNA and non-targeted metabolomics analyses Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-14 Shaopeng Wang, Xin Li, Bo Zhang, Yuxi Li, Kexu Chen, Huimin Qi, Mengqi Gao, Jin Rong, Lin Liu, Yuzhou Wan, Xi Dong, Meihua Yan, Liang Ma, Ping Li, Tingting Zhao
Tangshen formula (TSF) has an ameliorative effect on hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD), but the role played by the gut microbiota in this process is unknown. We conducted three batches of experiments to explore the role played by the gut microbiota: TSF administration, antibiotic treatment, and fecal microbial transplantation. NAFLD mice were induced with a high-fat
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HIF-1α Mediates Immunosuppression and Chemoresistance in Colorectal Cancer by Inhibiting CXCL9, −10 and −11 Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-13 Yixi Su, Jiaqi Liu, Yu Tian, Haiyan Dong, Mengchen Shi, Jingdan Zhang, Weiqian Li, Qiang Huang, Nanlin Xiang, Chen Wang, Jun Liu, Lingyuan He, Limei Hu, Ann M. Haberman, Huanliang Liu, Xiangling Yang
Uncertainty exists regarding the mechanisms by which hypoxia-inducible factors (HIFs) control CD8T-cell migration into tumor microenvironments. Here, we found that HIF-1α knockdown or overexpression resulted in increased or decreased CXCL9, −10, and −11 expression in vitro, respectively. Gene Set Variation Analysis revealed that elevated HIF-1α levels correlated with a poor prognosis, severe pathological
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Decoupling the mutual promotion of inflammation and oxidative stress mitigates cognitive decline and depression-like behavior in rmTBI mice by promoting myelin renewal and neuronal survival Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-13 Shenghua Lu, QianQian Ge, MengShi Yang, Yuan Zhuang, Xiaojian Xu, Fei Niu, Baiyun Liu, Runfa Tian
Repetitive mild traumatic brain injury (rmTBI) can lead to somatic, emotional, and cognitive symptoms that persist for years after the initial injury. Although the ability of various treatments to promote recovery after rmTBI has been explored, the optimal time window for early intervention after rmTBI is unclear. Previous research has shown that hydrogen-rich water (HRW) can diffuse through the blood-brain
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A combined transcriptomics and proteomics approach to reveal the mechanism of AEE relieving hyperlipidemia in ApoE-/- mice Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-13 Xiao-Rong Lu, Qi Tao, Zhe Qin, Xi-Wang Liu, Shi-Hong Li, Li-Xia Bai, Wen-Bo Ge, Ya-Xian Liu, Jian-Yong Li, Ya-Jun Yang
Hyperlipidemia caused by abnormal lipid metabolism has reached epidemic proportions. This phenomenon is also common in companion animals. Previous studies showed that AEE significantly improves abnormal blood lipids in hyperlipidemia rats and mice, but its mechanism is still not clear enough. In this study, the mechanism and potential key pathways of AEE on improving hyperlipidemia in mice were investigated
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Emerging role of N6-methyladenosine RNA modification in regulation of SARS-CoV-2 infection and virus-host interactions Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-13 Jiayi Liu, Lingli Chen, Xiongmin Guo, Bingrong Zhao, Juan Jiang
Since December 2019, the infection caused by Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) has posed an enormous threat to human health security worldwide. Constant mutation of viral genome and varying therapeutic responses of patients infected with this virus prompted efforts to uncover more novel regulators in the pathogenesis. The involvement of -methyladenosine, a modified form
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Tetramethylpyrazine Nitrone alleviates D-galactose-induced murine skeletal muscle aging and motor deficits by activating the AMPK signaling pathway Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-12 Lulin Nie, Kaiwu He, Chaoming Qiu, Qing Li, Bocheng Xiong, Chuanyue Gao, Xiufen Zhang, Mei Jing, Wei Wu, Jianjun Liu, Gaoxiao Zhang, Zaijun Zhang, Xifei Yang, Yewei Sun, Yuqiang Wang
Tetramethylpyrazine nitrone (TBN), a novel derivative of tetramethylpyrazine (TMP) designed and synthesized by our group, possesses multi-functional mechanisms of action and displays broad protective effects in vitro and in animal models of age-related brain disorders such as stroke, Alzheimer’s disease (AD), Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s disease (PD). In the present report, we
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Research progress in MCM family: Focus on the tumor treatment resistance Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-12 Yuxuan Tian, Yanhong Zhou, Fuxin Chen, Siyi Qian, Xingming Hu, Bin Zhang, Qiang Liu
Malignant tumors constitute a significant category of diseases posing a severe threat to human survival and health, thereby representing one of the most challenging and pressing issues in the field of biomedical research. Due to their malignant nature, which is characterized by a high potential for metastasis, rapid dissemination, and frequent recurrence, the prevailing approach in clinical oncology
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Characterisation of new in vitro models and identification of potentially active drugs in angiosarcoma Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-12 Marta Mendiola, Jani Saarela, Francisco Javier Escudero, Victoria Heredia-Soto, Swapnil Potdar, Silvia Rodriguez-Marrero, Maria Miguel, Jose Juan Pozo-Kreilinger, Alberto Berjon, Eduardo Ortiz-Cruz, Jaime Feliu, Andres Redondo
Angiosarcoma is a rare soft tissue sarcoma originating from endothelial cells. Given that current treatments for advanced disease have shown limited efficacy, alternative therapies need to be identified. In rare diseases, patient-derived cell models are crucial for screening anti-tumour activity. In this study, cell line models were characterised in 2D and 3D cultures. The cell lines’ growth, migration
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Specific transcription factors Ascl1 and Lhx6 attenuate diabetic neuropathic pain by modulating spinal neuroinflammation and microglial activation in mice Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-12 Sung-Min Hwang, Md. Mahbubur Rahman, Eun Jin Go, Yong Ho Kim, Chul-Kyu Park
Gamma-aminobutyric acid (GABA) neuronal system-related transcription factors (TFs) play a critical role in GABA production, and GABA modulates diabetic neuropathic pain (DNP). The present study investigated the therapeutic effects of intrathecal delivery of two TFs achaete-scute homolog 1 () and LIM homeobox protein 6 () in a mouse model of DNP and elucidated their underlying mechanisms. GABA-related
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Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-12 Fahad Khan, Pratibha Pandey, Meenakshi Verma, Seema Ramniwas, Dain Lee, Seungjoon Moon, Moon Nyeo Park, Tarun Kumar Upadhyay, Bonglee Kim
Ferroptosis, a novel form of regulated cell death characterized by dependence on iron and lipid peroxidation, has been implicated in a wide range of clinical conditions including neurological diseases, cardiovascular disorders, acute kidney failure, and various types of cancer. Therefore, it is critical to suppress cancer progression and proliferation. Ferroptosis can be triggered in cancer cells and
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Personalized cardiovascular risk assessment in Rheumatoid Arthritis patients using circulating molecular profiles and their modulation by TNFi, IL6Ri, and JAKinibs Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-12 Laura Muñoz-Barrera, Carlos Perez-Sanchez, Rafaela Ortega-Castro, Sagrario Corrales, Maria Luque-Tevar, Tomás Cerdó, Ismael Sanchez-Pareja, Pilar Font, Raquel Lopez-Mejías, Jerusalem Calvo, M.Carmen Abalos-Aguilera, Desiree Ruiz-Vilchez, Pedro Segui, Christian Merlo, José Perez-Venegas, Ma Dolores Ruiz Montesino, Carlos Rodriguez- Escalera, Carmen Romero Barco, Antonio Fernandez-Nebro, Natalia Mena
This study aimed to: 1) analyze the inflammatory profile of Rheumatoid Arthritis (RA) patients, identifying clinical phenotypes associated with cardiovascular (CV) risk; 2) evaluate biologic and targeted-synthetic disease-modifying antirheumatic drugs (b-DMARDs and ts-DMARDs’: TNFi, IL6Ri, JAKinibs) effects; and 3) characterize molecular mechanisms in immune-cell activation and endothelial dysfunction
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The double roles of T cell-mediated immune response in the progression of MASLD Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-12 Zigan Li, Shujun Wang, Qinchen Xu, Xin Su, Yunshan Wang, Lina Wang, Yong Zhang
Metabolic dysfunction–associated steatotic liver disease(MASLD), formerly known as non-alcoholic fatty liver disease(NAFLD), has become a major cause of chronic liver disease and a significant risk factor for hepatocellular carcinoma, which poses a huge burden on global public health and economy. MASLD includes steatotic liver disease, steatohepatitis, and cirrhosis, and the latter two cause great
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Perspective insights into versatile hydrogels for stroke: From molecular mechanisms to functional applications Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-12 Xinghan Wu, Tiejun Zhang, Jing Jia, Yining Chen, Ying Zhang, Zhenwei Fang, Chenyu Zhang, Yang Bai, Zhengjun Li, Yuwen Li
As the leading killer of life and health, stroke leads to limb paralysis, speech disorder, dysphagia, cognitive impairment, mental depression and other symptoms, which entail a significant financial burden to society and families. At present, physiology, clinical medicine, engineering, and materials science, advanced biomaterials standing on the foothold of these interdisciplinary disciplines provide
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Green nanotech paradigm for enhancing sesquiterpene lactone therapeutics in cancer Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Mehak Zahra, Heidi Abrahamse, Blassan P. George
In the field of cancer therapy, sesquiterpene lactones (SLs) derived from diverse species demonstrate noteworthy bioactivity. However, the translation of their full therapeutic potential into clinical applications encounters significant challenges, primarily related to solubility, bioavailability, and precise drug targeting. Despite these obstacles, our comprehensive review introduces an innovative
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Compounding engineered mesenchymal stem cell-derived exosomes: A potential rescue strategy for retinal degeneration Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Yao Wang, Xianning Liu, Bei Wang, Hanhan Sun, Yiqian Ren, Hongbing Zhang
The prevalence of retinal degenerative diseases, including age-related macular degeneration and retinitis pigmentosa, has been increasing globally and is linked to the aging population and improved life expectancy. These diseases are characterized by chronic, progressive neuronal damage or depletion of the photoreceptor cells in the retina, and limited effective treatment options are currently available
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Icariin ameliorates osteoporosis in ovariectomized rats by targeting Cullin 3/Nrf2/OH pathway for osteoclast inhibition Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Yuhao Si, Yan Li, Kuan Gu, Heng Yin, Yong Ma
Osteoporosis, characterized by low bone mass and bone microarchitecture breakdown, has become a growing public health problem. The increase in oxidative stress could lead to an imbalance between osteoblasts-mediated osteogenesis and osteoclast-mediated bone resorption, which gives rise to osteoporosis. Nrf2 is a master transcription factor that regulates oxidative stress and has recently been reported
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Exploring the gut microbiota and its potential as a biomarker in gliomas Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Dana Aljarrah, Naima Chalour, Amine Zorgani, Tracy Nissan, Md Zahidul I. Pranjol
Gut microbiome alterations are associated with various cancers including brain tumours such as glioma and glioblastoma. The gut communicates with the brain via a bidirectional pathway known as the gut-brain axis (GBA) which is essential for maintaining homeostasis. The gut microbiota produces many metabolites including short chain fatty acids (SCFAs) and essential amino acids such as glutamate, glutamine
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The role of Akkermansia muciniphila in colorectal cancer: A double-edged sword of treatment or disease progression? Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Elnaz Faghfuri, Pourya Gholizadeh
Colorectal cancer (CRC) is the second most cancer-related death worldwide. In recent years, probiotics have been used to reduce the potential risks of CRC and tumors with various mechanisms. Different bacteria have been suggested to play different roles in the progression, prevention, or treatment of CRC. is considered a next-generation probiotic for preventing and treating some diseases. Therefore
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Reducing brain Aβ burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Huey-Jen Tsay, Yu-Ling Gan, Yu-Han Su, Yu-Yo Sun, Heng-Hsiang Yao, Hui-Wen Chen, Ying-Ting Hsu, John Tsu-An Hsu, Horng-Dar Wang, Feng-Shiun Shie
High-fat diet (HFD)-induced fatty liver disease is a deteriorating risk factor for Alzheimer’s disease (AD). Mitigating fatty liver disease has been shown to attenuate AD-like pathology in animal models. However, it remains unclear whether enhancing Aβ clearance through immunotherapy would in turn attenuate HFD-induced fatty liver or whether its efficacy would be compromised by long-term exposure to
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Oleanolic acid exerts bone anabolic effects via activation of osteoblastic 25-hydroxyvitamin D 1-alpha hydroxylase Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Wen-Xuan Yu, Christina Chui-Wa Poon, Li-Ping Zhou, Ka-Ying Wong, Si-Si Cao, Chung-Yan Lam, Wayne Yuk-wai Lee, Man-Sau Wong
Oleanolic acid (OA) is previously shown to exert bone protective effects in aged animals. However, its role in regulating osteoblastic vitamin D bioactivation, which is one of major causes of age-related bone loss, remains unclear. Our results revealed that treatment of OA significantly increased skeletal CYP27B1 expression and circulating 1,25(OH)D in ovariectomized mice ( <0.01). Moreover, OA upregulated
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Pharmacokinetic considerations for enhancing drug repurposing opportunities of anthelmintics: Niclosamide as a case study Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Jeong In Seo, Geun-woo Jin, Hye Hyun Yoo
Recently, anthelmintics have showcased versatile therapeutic potential in addressing various diseases, positioning them as promising candidates for drug repurposing. However, challenges such as low bioavailability and a lack of a solid pharmacokinetic basis impede successful repurposing. To overcome these flaws, we aimed to investigate the key pharmacokinetic factors of anthelmintics mainly focusing
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The modulatory effects of large and small extracellular vesicles from normal human urine on calcium oxalate crystallization, growth, aggregation, adhesion on renal cells, and invasion through extracellular matrix: An in vitro study Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Sudarat Hadpech, Sakdithep Chaiyarit, Somsakul Phuangkham, Sirirat Sukphan, Visith Thongboonkerd
Urinary extracellular vesicles (uEVs) play important roles in physiologic condition and various renal/urological disorders. However, their roles in kidney stone disease remain unclear. This study aimed to examine modulatory effects of large and small uEVs derived from normal human urine on calcium oxalate (CaOx) crystals (the main component in kidney stones). After isolation, large uEVs, small uEVs
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Effect of sacubitril/valsartan on the hypertensive heart in continuous light-induced and lactacystin-induced pre-hypertension: Interactions with the renin-angiotensin-aldosterone system Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Fedor Simko, Peter Stanko, Kristina Repova, Tomas Baka, Kristina Krajcirovicova, Silvia Aziriova, Oliver Domenig, Stefan Zorad, Michaela Adamcova, Ludovit Paulis
This study investigated whether sacubitril/valsartan or valsartan are able to prevent left ventricular (LV) fibrotic remodelling and dysfunction in two experimental models of pre-hypertension induced by continuous light (24 hours/day) exposure or by chronic lactacystin treatment, and how this potential protection interferes with the renin-angiotensin-aldosterone system (RAAS). Nine groups of three-month-old
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The essential oil of Melaleuca alternifolia incorporated into hydrogel induces antimicrobial and anti-inflammatory effects on infected wounds by Staphylococcus aureus Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Beatriz Gomes Vila Nova, Lucas dos Santos Silva, Marcos da Silva Andrade, Amanda Vitória Sevidanes de Santana, Leticia Cely Tavares da Silva, Gabrielle Chaves Sá, Ivana Fiquene Zafred, Pedro Henrique de Aguiar Moreira, Cristina Andrade Monteiro, Luís Cláudio Nascimento da Silva, Afonso Gomes Abreu
is one of the most common bacterial isolates found in wounds. Thus, innovative dressings, such as hydrogels, are interesting vehicles for incorporating bioactive compounds like those from essential oil (MaEO). In this study, we evaluated the antimicrobial and anti-inflammatory potential of MaEO incorporated into an alginate and chitosan hydrogel for treating wounds infected by . The hydrogel incorporated
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Electroacupuncture alleviates intestinal inflammation via a distinct neuro-immune signal pathway in the treatment of postoperative ileus Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Shuchang Liu, Wei Fu, Jingnan Fu, Guibing Chen, Yuxin He, Ting Zheng, Tao Ma
The induction of intestinal inflammation as a result of abdominal surgery is an essential factor in postoperative ileus (POI) development. Electroacupuncture (EA) at ST36 has been demonstrated to relieve intestinal inflammation and restore gastrointestinal dysmotility in POI. This study aims to elucidate the neuroimmune pathway involved in the anti-inflammatory properties of EA in POI. After intestinal
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Intra-bone marrow injection with engineered Lactococcus lactis for the treatment of metastatic tumors: Primary report Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Rui Liu, Junmeng Zhu, Aoxing Chen, Yue Fan, Lin Li, Yi Mei, Yan Wang, Xiaonan Wang, Baorui Liu, Qin Liu
Bone marrow has the capacity to produce different types of immune cells, such as natural killer cells, macrophages, dendritic cells (DCs) and T cells. Improving the activation of immune cells in the bone marrow can enhance the therapy of bone metastases. Previously, we designed an engineered probiotic Lactococcus lactis, capable of expressing a fusion protein of Fms-like tyrosine kinase 3 ligand and
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Paeonol promotes longevity and fitness in Caenorhabditis elegans through activating the DAF-16/FOXO and SKN-1/Nrf2 transcription factors Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-11 Rong Li, Qingping Yi, Jinsong Wang, Yuanxin Miao, Qingchan Chen, Yan Xu, Mingfang Tao
Paeonol, as one of the most abundant plant-derived polyphenols, has multiple bioactivities including anti-inflammatory, anti-tumor, and anti-cardiovascular diseases. Nevertheless, the anti-aging effects and related mechanisms of paeonol are rarely reported. In this study, we found that paeonol significantly prolonged the mean lifespan of () by 28.49% at a dose of 200 μM. Moreover, paeonol promoted
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Therapeutic effects and molecular mechanisms of quercetin in gynecological disorders Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-09 Xian Jian, Chen Shi, Weichen Luo, Liyuan Zhou, Lili Jiang, Kuiran Liu
Quercetin is a representative flavonoid that is widely present in fruits, herbs, and vegetables. It is also an important active core component in traditional Chinese medicines. As an important flavonoid, quercetin has various properties and exerts antioxidant, anti-inflammatory, and cardioprotective effects. The public interest in quercetin is increasing, and quercetin has been used to prevent or treat
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Regulation of histone acetylation by garcinol blocks the reconsolidation of heroin-associated memory Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-09 Junzhe Cheng, Binbin Wang, Hongkun Hu, Xinzhu Lin, Yuhang Liu, Jiang Lin, Jinlong Zhang, Shuliang Niu, Jie Yan
Drug-associated long-term memories underlie substance use disorders, including heroin use disorder (HUD), which are difficult to eliminate through existing therapies. Addictive memories may become unstable when reexposed to drug-related cues and need to be stabilized again through protein resynthesis. Studies have shown the involvement of histone acetylation in the formation and reconsolidation of
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Targeting MAPK-ERK/JNK pathway: A potential intervention mechanism of myocardial fibrosis in heart failure Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-09 Zeyu Zhang, Zhihua Yang, Shuai Wang, Xianliang Wang, Jingyuan Mao
Myocardial fibrosis is a significant pathological basis of heart failure. Overactivation of the ERK1/2 and JNK1/2 signaling pathways of MAPK family members synergistically promotes the proliferation of myocardial fibroblasts and accelerates the development of myocardial fibrosis. In addition to some small molecule inhibitors and Western drugs, many Chinese medicines can also inhibit the activity of
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Gut microbiome-metabolites axis: A friend or foe to colorectal cancer progression Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-09 Hao Wu, Wenmeng Ma, Yiyao Wang, Yuanyuan Wang, Xun Sun, Qianqian Zheng
An expanding corpus of research robustly substantiates the complex interrelation between gut microbiota and the onset, progression, and metastasis of colorectal cancer. Investigations in both animal models and human subjects have consistently underscored the role of gut bacteria in a variety of metabolic activities, driven by dietary intake. These activities include amino acid metabolism, carbohydrate
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Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-09 Zhiqiao Dang, Haijie Li, Shishan Xue, Baowei Shao, Yansong Ning, Guohai Su, Fengquan Zhang, Wenqian Yu, Shuai Leng
Aortic aneurysm/dissection (AAD) is a serious cardiovascular condition characterized by rapid onset and high mortality rates. Currently, no effective drug treatment options are known for AAD. AAD pathogenesis is associated with the phenotypic transformation and abnormal proliferation of vascular smooth muscle cells (VSMCs). However, endogenous factors that contribute to AAD progression remain unclear
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A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer’s mice Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-09 Khaled S. Abd-Elrahman, Tash-Lynn L. Colson, Shaarika Sarasija, Stephen S.G. Ferguson
Alzheimer's disease (AD) is the most prevalent type of dementia, disproportionately affecting females, who make up nearly 60% of diagnosed cases. In AD patients, the accumulation of beta-amyloid (Aβ) in the brain triggers a neuroinflammatory response driven by neuroglia, worsening the condition. We have previously demonstrated that VU0486846, an orally available positive allosteric modulator (PAM)
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Intra-abdominal transplantation of PLGA/PCL/M13 phage electrospun scaffold induces self-assembly of lymphoid tissue-like structure Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-09 Zohreh Safari, Majid Sadeghizadeh, Ahmad Zavaran Hosseini, Ali Hazrati, Sara Soudi
Lymphoid organs are the main structural components of the immune system. In the current research, the mixture of poly lactic-co-glycolic acid (PLGA), polycaprolactone (PCL), and M13 phage or its RGD-modified form was used in the construction of a fibrillar scaffold using the electrospinning method. The constructs were transplanted intra-abdominally and examined for the formation of lymphoid-like tissues
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GSH-activable heterotrimeric nano-prodrug for precise synergistic therapy of TNBC Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-09 Xiaojing Zhang, Yansong Chen, Jingwei Tang, Chen Chen, Yanfeng Sun, Hao Zhang, Mengxiang Qiao, Gongsheng Jin, Xianfu Liu
Combination chemotherapy is an effective approach for triple-negative breast cancer (TNBC) therapy, especially when drugs are administered at specific optimal ratios. However, at present, strategies involving precise and controllable ratios based on effective loading and release of drugs are unavailable. Herein, we designed and synthesized a glutathione (GSH)--responsive heterotrimeric prodrug and
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Exosomal ncRNAs: Multifunctional contributors to the immunosuppressive tumor microenvironment of hepatocellular carcinoma Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-08 Qi Huang, Xin Zhong, Jing Li, Rui Hu, Jinyu Yi, Jialing Sun, Youhua Xu, Xiaozhou Zhou
Hepatocellular carcinoma (HCC) is a malignant liver cancer characterized by aggressive progression, unfavorable prognosis, and an increasing global health burden. Therapies that precisely target immunological checkpoints and immune cells have gained significant attention as possible therapeutics in recent years. In truth, the efficacy of immunotherapy is heavily contingent upon the tumor microenvironment
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Effect of high-dose vitamin C on renal ischemia-reperfusion injury Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-08 Seo Hee Ko, Ji Hae Jun, Ju Eun Oh, Eunah Shin, Young-Lan Kwak, Jae-Kwang Shim
Acute kidney injury frequently occurs after cardiac surgery, and is primarily attributed to renal ischemia-reperfusion (I/R) injury and inflammation from surgery and cardiopulmonary bypass. Vitamin C, an antioxidant that is often depleted in critically ill patients, could potentially mitigate I/R-induced oxidative stress at high doses. We investigated the effectiveness of high-dose vitamin C in preventing
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Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-08 Le-Jun Huang, Jin-Xia Lan, Jin-Hua Wang, Hao Huang, Kuo Lu, Zhi-Nuo Zhou, Su-Ya Xin, Zi-Yun Zhang, Jing-Yang Wang, Ping Dai, Xiao-Mei Chen, Wen Hou
Sanguinarine is a quaternary ammonium benzophenanthine alkaloid found in traditional herbs such as , , , and . It has been proven to possess broad-spectrum biological activities, such as antitumor, anti-inflammatory, antiosteoporosis, neuroprotective, and antipathogenic microorganism activities. In this paper, recent progress on the biological activity and mechanism of action of sanguinarine and its
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Adenosine A2B receptor agonist improves epidermal barrier integrity in a murine model of epidermal hyperplasia Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-08 Asunción Marín-Castejón, Miguel Marco-Bonilla, M. Carmen Terencio, Jorge Arasa, M. Carmen Carceller, M. Luisa Ferrandiz, M. Antonia Noguera, Rosa Andrés-Ejarque, M. Carmen Montesinos
Adenosine regulates multiple physiological processes through the activation of four receptor subtypes, of which the A adenosine receptor (AAR) has the lowest affinity for adenosine. Being the adenosine receptor subtype most prominently expressed in epidermis, we recently described the antiproliferative and anti-inflammatory effect of the selective AAR agonist BAY60–6583 (BAY) in human keratinocytes
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PP2A as a potential therapeutic target for breast cancer: Current insights and future perspectives Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-08 Yalong Qi, Lixi Li, Yuhan Wei, Fei Ma
Breast cancer has become the most prevalent malignancy worldwide; however, therapeutic efficacy is far from satisfactory. To alleviate the burden of this disease, it is imperative to discover novel mechanisms and treatment strategies. Protein phosphatase 2 A (PP2A) comprises a family of mammalian serine/threonine phosphatases that regulate many cellular processes. PP2A is dysregulated in several human
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Dendrobium officinale regulate lipid metabolism in diabetic mouse liver via PPAR-RXR signaling pathway: Evidence from an integrated multi-omics analysis Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-08 Junju Zou, Qianbo Song, Pang Chui Shaw, Zhong Zuo
(DEN) is recognized as a kind of functional food that can effectively ameliorate endocrine and metabolic disruptions. This study delved into the pharmacological mechanism of DEN on hepatic lipotoxicity associated with Type II diabetes mellitus (T2DM). study experiments on mice indicated that DEN treatment notably enhanced liver function, decreased blood lipid levels, and improved insulin sensitivity
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Anisamide-conjugated hairpin antisense oligonucleotides prodrug co-delivering doxorubicin exhibited enhanced anticancer efficacy Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-08 Zhe Zhang, Zuyi Chen, Shuangshuang Liu, Zhenyu Xiao, Yuan Luo, Xiaochen Pan, Xuesong Feng, Liang Xu
Antisense oligonucleotides (ASONs)-based therapeutics offers tremendous promise for the treatment of diverse diseases. However, there is still a need to develop ASONs with enhanced stability against enzymes, improved drug delivery, and enhanced biological potency. In this study, we propose a novel anisamide (AA)-conjugated hairpin oligonucleotide prodrug loading with chemotherapeutic agent (doxorubicin
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Antiseizure effects of Lilii Bulbus on pentylenetetrazol kindling-induced seizures in mice: Involvement of Reelin, Netrin-1, and semaphorin Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-08 Hee Ra Park, Mudan Cai
Lilii Bulbus ( Thunberg) has a proneurogenic effect on the hippocampus. However, its effects on epilepsy and associated pathological features remain unknown. In this study, we investigated the antiseizure effects of a water extract of Lilii Bulbus (WELB) in mouse model of pentylenetetrazol (PTZ)-induced seizure. Mice were injected with PTZ once every 48 h until full kindling was achieved. WELB (100
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Gardenin A treatment attenuates inflammatory markers, synuclein pathology and deficits in tyrosine hydroxylase expression and improves cognitive and motor function in A53T-α-syn mice Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-08 Wyatt Hack, Noah Gladen-Kolarsky, Swarnali Chatterjee, Qiaoli Liang, Urmila Maitra, Lukasz Ciesla, Nora E. Gray
Oxidative stress and neuroinflammation are widespread in the Parkinson’s disease (PD) brain and contribute to the synaptic degradation and dopaminergic cell loss that result in cognitive impairment and motor dysfunction. The polymethoxyflavone Gardenin A (GA) has been shown to activate the NRF2-regulated antioxidant pathway and inhibit the NFkB-dependent pro-inflammatory pathway in a model of PD. Here
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Oseltamivir enhances 5-FU sensitivity in esophageal squamous carcinoma with high SPNS1 Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-08 Xin Yang, Ye Jiao, Yingying Zhang, Meng Sun, Yingzhen Gao, Yan Zhou, Heng Xiao, Jing Ren, Zhinan Zhou, Yuanfang Zhai, Bin Song, Ling Zhang, Pengzhou Kong
Sphingolipid transporter 1 (SPNS1) is a significant differentially expressed gene (DEGs) in esophageal squamous cell carcinoma (ESCC). According to 3 pairs clinic cohorts, transcriptomic (155 pairs of ESCC samples and GSE53624, and proteomic data from PXD021701 including 124 ESCC samples) we found that SPNS1 was significantly higher in ESCC tissues compared to adjacent normal esophagus tissues. ESCC
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Inhibition of PTPRE suppresses tumor progression and improves sorafenib response in hepatocellular carcinoma Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-08 Renshun Dong, Tianci Wang, Wei Dong, He Zhu, Qiumeng Liu, Huifang Liang, Xiaoping Chen, Bixiang Zhang, Xuewu Zhang
Hepatocellular carcinoma (HCC) has a poor prognosis, and the efficacy of current therapeutic strategies is extremely limited in advanced diseases. Our previous study reported that protein tyrosine phosphatase receptor epsilon (PTPRE) is a promoting factor in HCC progression. In this study, our objective was to evaluate the treatment effect of PTPRE inhibitors in different HCC preclinical models. Our
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Curcumin encapsulated in milk small extracellular vesicles as a nanotherapeutic alternative in experimental chronic liver disease Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-07 Virginia Albaladejo-García, Laura Morán, Ana Santos-Coquillat, María I. González, Hui Ye, Elena Vázquez Ogando, Javier Vaquero, Francisco Javier Cubero, Manuel Desco, Beatriz Salinas
Curcumin is a natural molecule widely tested in preclinical and clinical studies due to its antioxidant and anti-inflammatory activity. Nevertheless, its high hydrophobicity and low bioavailability limit applications. To overcome curcumin´s drawbacks, small extracellular vesicles (sEVs) have emerged as potential drug delivery systems due to their non-immunogenicity, nanometric size and amphiphilic
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Oxyimperatorin attenuates LPS-induced microglial activation in vitro and in vivo via suppressing NF-κB p65 signaling Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-06 Changcheng Lu, Chen Huang, Shuhui Qu, Huiyuan Lin, Hai-Jing Zhong, Cheong-Meng Chong
Microglia-mediated neuroinflammation is an important pathological feature in many neurological diseases; thus, suppressing microglial activation is considered a possible therapeutic strategy for reducing neuronal damage. Oxyimperatorin (OIMP) is a member of furanocoumarin, isolated from the medicinal herb . However, it is unknown whether OIMP can suppress the neuroinflammation. To investigate the neuroprotective
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Dual effect of anandamide on spinal nociceptive transmission in control and inflammatory conditions Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-06 Monica Pontearso, Jakub Slepicka, Anirban Bhattacharyya, Diana Spicarova, Jiri Palecek
Anandamide (AEA) is an important modulator of nociception in the spinal dorsal horn, acting presynaptically through Cannabinoid (CB) and Transient receptor potential vanilloid (TRPV1) receptors. The role of AEA (1 µM, 10 µM, and 30 µM) application on the modulation of nociceptive synaptic transmission under control and inflammatory conditions was studied by recording miniature excitatory postsynaptic
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N6-methyladenosine (m6A) modification in hepatocellular carcinoma Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-06 Hehua Ma, Yuxin Hong, Zhenzhen Xu, Zuyi Weng, Yuanxun Yang, Dandan Jin, Zhiyou Chen, Jing Yue, Xuan Zhou, Zhi Xu, Fei Fei, Juan Li, Wei Song
Hepatocellular carcinoma (HCC) is one of the deadliest cancers of human, the tumor-related death of which ranks third among the common malignances. Nmethyladenosine (mA) methylation, the most abundant internal modification of RNA in mammals, participates in the metabolism of mRNA and interrelates with ncRNAs. In this paper, we overviewed the complex function of mA regulators in HCC, including regulating
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Polycationic phosphorous dendrimer potentiates multiple antibiotics against drug-resistant mycobacterial pathogens Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-06 Mohmmad Imran, Shriya Singh, Mohammad Naiyaz Ahmad, Pradip Malik, Atri Mukhopadhyay, Karan Singh Yadav, Umesh D. Gupta, Madhav N. Mugale, Kalyan Mitra, Kishore K. Srivastava, Sidharth Chopra, Serge Mignani, Evgeny Apartsin, Jean-Pierre Majoral, Arunava Dasgupta
(Mtb), causative agent of tuberculosis (TB) and non-tubercular mycobacterial (NTM) pathogens such as are one of the most critical concerns worldwide due to increased drug-resistance resulting in increased morbidity and mortality. Therefore, focusing on developing novel therapeutics to minimize the treatment period and reducing the burden of drug-resistant Mtb and NTM infections are an urgent and pressing
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Retraction notice to “Corrigendum to ‘LINC01116 targets miR-520a-3p and affects IL6R to promote the proliferation and migration of osteosarcoma cells through the Jak-stat signaling pathway’” [Biomed. Pharmacother. 111 (2019) 1508-1508] Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-05 Butian Zhang, Lili Yu, Ning Han, Zhenzhen Hu, Shuang Wang, Lei Ding, Jinlan Jiang
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FM19G11-loaded nanoparticles modulate energetic status and production of reactive oxygen species in myoblasts from ALS mice Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-05 Claudia Malacarne, Eleonora Giagnorio, Cristina Chirizzi, Marco Cattaneo, Fulvia Saraceno, Paola Cavalcante, Silvia Bonanno, Renato Mantegazza, Victoria Moreno-Manzano, Giuseppe Lauria, Pierangelo Metrangolo, Francesca Baldelli Bombelli, Stefania Marcuzzo
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons. Considerable evidence indicates that early skeletal muscle atrophy plays a crucial role in the disease pathogenesis, leading to an altered muscle-motor neuron crosstalk that, in turn, may contribute to motor neuron degeneration. Currently, there is no effective treatment for ALS, highlighting the
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Glycogen synthase kinase-3: A potential immunotherapeutic target in tumor microenvironment Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-05 Jingyi Liang, Meng Yu, Yunong Li, Lin Zhao, Qian Wei
Glycogen synthase kinase-3(GSK-3) is a protein kinase that can phosphorylate over a hundred substrates and regulate cell differentiation, proliferation, and death. Researchers have acknowledged the pivotal role of abnormal activation of GSK-3 in the progression of various diseases over the past few decades. Recent studies have mostly concentrated on investigating the function of GSK-3 in the tumor
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Changes in chromatin accessibility and transcriptional landscape induced by HDAC inhibitors in TP53 mutated patient-derived colon cancer organoids Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-05 Teresa Gagliano, Emanuela Kerschbamer, Umberto Baccarani, Martina Minisini, Eros Di Giorgio, Emiliano Dalla, Christian X. Weichenberger, Vittorio Cherchi, Giovanni Terrosu, Claudio Brancolini
Here we present the generation and characterization of patient-derived organoids (PDOs) from colorectal cancer patients. PDOs derived from two patients with TP53 mutations were tested with two different HDAC inhibitors (SAHA and NKL54). Cell death induction, transcriptome, and chromatin accessibility changes were analyzed. HDACIs promote the upregulation of low expressed genes and the downregulation
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The bone-protective benefits of kaempferol combined with metformin by regulation of osteogenesis-angiogenesis coupling in OVX rats Biomed. Pharmacother. (IF 7.5) Pub Date : 2024-03-05 Zhongyuan Zhang, Wenshu Xu, Zhenhua Zhang, Xiaoxue Chen, Hui Jin, Ningning Jiang, Hui Xu
This study was to investigate the potential mechanisms of treatment with metformin (Met) combined with kaempferol (Kae) against postmenopausal osteoporosis. Experiments were conducted in both ovariectomy (OVX)-induced osteoporosis rats and in vitro using RAW264.7 cells, MC3T3-E1 cells, and HUVECs. Results demonstrated the therapeutic effect of Met combined with Kae on osteoporosis. In vivo, Kae alone