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Moving forward while looking back: Reflections on the history and future of the journal Experimental and Clinical Psychopharmacology. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2024-1-25 Kelly E Dunn
In this editorial, the incoming editor for Experimental and Clinical Psychopharmacology (ECP) reflects on the history and future of the journal. The author looks forward to working together with the American Psychological Association publishing community and ECP authors, reviewers, and board members as they navigate changes to their publishing policies and procedures. (PsycInfo Database Record (c)
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Discriminative stimulus properties of two training doses of gabapentin in rats: Substitution by pregabalin, diazepam, and pentobarbital. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2024-01-18 Adam J Prus, Madeline T Van Fossen, Alexandria N Iannucci, Alexia G Dalton, Joshua N Prete
Gabapentin is used for the treatment of many conditions, including seizures, pain, and anxiety. Increasing reports of nonprescribed use suggest that gabapentin may elicit positive subjective effects. The present study was conducted to examine the subjective effects of gabapentin using rats trained to discriminate either a 30.0 mg/kg or 300.0 mg/kg dose of gabapentin versus vehicle on a two-choice drug
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Changes in weight among individuals with psychiatric conditions or socioeconomic disadvantage assigned to smoke very low nicotine content cigarettes. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2024-01-18 Roxanne F Harfmann, Sarah H Heil, Janice Y Bunn, L Morgan Snell, Jennifer W Tidey, Stacey C Sigmon, Diann E Gaalema, Dustin C Lee, Joanna M Streck, Cecilia L Bergeria, Danielle R Davis, Shirley Plucinski, Stephen T Higgins
Nicotine abstinence leads to weight gain, which could be an unintended consequence of a nicotine reduction policy. This secondary analysis used weekly assessments of weight and ratings of "increased appetite/hunger/weight gain" collected in three 12-week, randomized controlled trials evaluating the effects of cigarettes differing in nicotine dose (15.8, 2.4, or 0.4 mg/g) among individuals with affective
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Cannabis use and binge eating: Examining the relationship between cannabis use and clinical severity among adults with binge eating. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2024-01-18 Megan L Wilkinson, Claire Trainor, Elizabeth Lampe, Emily K Presseller, Adrienne Juarascio
Cannabis use is prevalent among individuals with binge eating (BE; i.e., the inability to control eating behavior). Yet, only two studies to date (both over 20 years old) have tested if cannabis use relates to clinical severity among BE samples. Characterizing the relationship between cannabis use, eating disorder (ED) severity, and other psychiatric symptoms in BE samples is necessary for informing
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Development and validation of a reasons for electronic cigarette use questionnaire. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2024-01-18 David M Ledgerwood, Danishi K Bedi, Mannat K Bedi, Ciara N Cannoy, Krithika Prakash, Alanna E Foulon, ShayLin Excell, Leslie H Lundahl
People use electronic cigarettes (e-cigarettes) for many reasons, but currently there are no comprehensive assessments of the motivations for tobacco vaping. The aim of the present study is to develop and test the initial construct validity of a new measure to assess reasons for e-cigarette use. We developed a 56-item measure based on the e-cigarette literature. This measure, along with demographic
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Progress and promise: A brief reflection on my time as editor of Experimental and Clinical Psychopharmacology. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-12-21 William W Stoops
This editorial focuses on William W. Stoops time as editor of Experimental and Clinical Psychopharmacology. Stoops ends his time with gratitude for all who have contributed to the journal's success over the past years, pride for what they have accomplished, and excitement for the journal's future. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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Randomized trial assessing the effect of the JUUL system on switching away from cigarettes and smoking reduction among U.S. adults who smoke cigarettes. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-12-21 Yingying Xu, Nicholas I Goldenson, Shivaani Prakash, Erik M Augustson, Saul Shiffman
Observational studies show high rates of switching away from cigarettes among adult purchasers of JUUL-brand electronic nicotine delivery system (ENDS); data are needed to evaluate switching with JUUL in randomized general population trials. The association of ENDS flavor availability and switching is pertinent. This study assessed switch rates and smoking reduction among participants randomized to
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The role of anhedonia in the relationship between adverse childhood experiences (ACEs), alcohol use disorder symptoms, and food addiction symptoms in a sample of emerging adults with histories of heavy drinking. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-12-21 Mary Takgbajouah, Nate Barnes, James MacKillop, James G Murphy, Joanna Buscemi
Previous research has shown that (ACEs) are associated with negative health outcomes, including depression, problematic alcohol use, and disordered patterns of overeating, including food addiction (FA). Moreover, anhedonia, or an inability to feel pleasure, has been also shown to increase risk for problematic alcohol use, as well as FA. It is possible that anhedonia may be implicated in health risk
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A test of competing mediators linking trouble sleeping to cannabis use in adolescents and emerging adults. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-12-21 Benjamin L Berey, Samuel Meisel, Melissa Pielech, Jamie E Parnes, Hayley Treloar Padovano, Robert Miranda
This study examined day-level associations between trouble sleeping and three cannabis-use indices (likelihood/quantity of use and impaired control). We evaluated behavioral and cognitive mediators of the association between trouble sleeping and cannabis outcomes. Youth (N = 86, ages 15-24, 48.8% female, 58.8% White, 18.6% Latine) who regularly used cannabis were recruited for an intervention study
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Cannabis as a shareable commodity in a social discounting task. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-12-21 Toby Hatch, Anissa Olona, Victoria Lopez, Paul Romanowich
Cannabis use and cannabis use disorder diagnoses continue to increase in United States college-aged students as more states legalize recreational cannabis. Previous studies have attempted to associate cannabis use with delay discount rates, which involves participants making choices for smaller sooner versus larger later hypothetical rewards. More smaller sooner choices result in higher discount rates
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Adaptation of commodity purchase tasks to identify substitutable substance-free alternative activities for alcohol use. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-12-21 Sarah C Weinsztok, Derek D Reed, Brandon P Miller, Michael Amlung
Behavioral economic frameworks emphasize the importance of contextual influences on alcohol use; therefore, identifying relative demand for alcohol versus other commodities is of importance. Cross-commodity purchase tasks allow participants to make choices across multiple concurrently available commodities and can thereby pinpoint interactions among those commodities. These tasks may help identify
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Reward learning capacity in a community sample of individuals who use cannabis. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-12-21 Olivia Turner, Kiran Punia, Diego A Pizzagalli, James MacKillop, Iris M Balodis
Cannabis use has been linked to deficient reward processing; however, little is known about its relation to the specific construct of reward learning, in which behavior is modified through associating novel stimuli with a positive outcome. The probabilistic reward task was used to objectively evaluate reward learning in 38 individuals who use recreational cannabis and 34 control comparison participants
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A novel abuse liability assessment of e-cigarettes in young adults ii: Reinforcement enhancement and follow-up assessment. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-12-07 Ari P Kirshenbaum, Virginia Kelsey, Mia Cooper, Anthony E Richardson, John R Hughes
A double-blind study was performed to test the abuse liability of electronic nicotine delivery systems (ENDS) in young adults; in particular, the influence of nicotine on reward sensitivity was assessed. A total of 53 healthy nonusers participated in experimental sessions during which they played a video game made available on a progressive ratio schedule of reinforcement and self-administered nicotine
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Pregaming potentiates risk between UPPS-P impulsivity and day-level drinking behavior: A test of person-environment transactions theory. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-11-30 Scott E King, Jack T Waddell, William R Corbin
Pregaming represents a uniquely high-risk drinking event for young adults, and subfacets of impulsivity are robust predictors of alcohol use and related negative outcomes. Further, it is likely that pregame events contain social and physical stimuli that are particularly appealing for impulsive individuals, thus exacerbating risk for negative outcomes. However, no prior studies have investigated the
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Comparative assessment of psychometric performance on the adjusting amounts versus the 21-item Monetary Choice Delay Discounting tasks among young adult substance users. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-11-27 Alba González-Roz,Víctor Martínez-Loredo,Álvaro Postigo,Jin H Yoon
Delay discounting (DD) assessments offer a wide variety of procedures to suit specific clinical and research needs. This study compared the reliability and validity of two DD tasks: (a) an adjusting amounts task presented on a computer (AAC) and (b) the 21-item Monetary Choice Task, which was administered online (MCT). Participants were 1,573 Spanish young-adults reporting past-month substance use
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Initial validation of the expectancies for Benzodiazepine Analgesia Scale. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-11-27 Emma C Lape,Jessica M Powers,Lisa R LaRowe,Joseph W Ditre
Chronic pain populations exhibit greater prevalence of benzodiazepine (BZD) prescription (vs. the general population) and greater likelihood of BZD use not as prescribed and dependence symptoms. Individuals report taking BZDs for pain relief, potentially contributing to maintenance/escalation of BZD use and hazardous couse with prescription opioids. Identifying cognitive factors underlying pain-BZD
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Mental health facilities with ketamine infusion therapy in the United States in 2020: Co-location of dual diagnosis mental health and substance use disorder treatment. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-11-02 Orrin D Ware
Ketamine is an anesthetic that has been identified as an effective therapy for depressive disorders and related symptoms. Some studies have identified ketamine as having the potential to reduce substance use among individuals with a substance use disorder (SUD)-alongside psychotherapy. Further, SUDs often co-occur with depressive disorders. Using the National Mental Health Services Survey 2020, this
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Interpretations and experiences of subjective effects for alcohol alone and when combined with cannabis: A mixed-methods approach. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-11-02 Cassandra L Boness,Ashley N Linden-Carmichael
Subjective effects generally describe the feelings one has when consuming substances. There are several tools available for measuring alcohol-related subjective effects but there are reasons to believe that effects are interpreted differently across participants. The assessment of alcohol-related subjective effects is further complicated by the fact that many people use other substances with alcohol
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Decision-making task performance and patterns of methamphetamine use in people assigned male at birth who have sex with men. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-11-02 Michael J Li,Adiba Hassan,Marjan Javanbakht,Pamina M Gorbach,Steven J Shoptaw
This study aims to determine whether performance on the Iowa Gambling Task (IGT), a simulation of risk-taking when faced with loss, is associated with greater frequency of methamphetamine (MA) use and challenges reducing or stopping MA use. The parent mSTUDY is a Los Angeles County-based longitudinal study of substance use and HIV risk in predominately Black/African American and Latinx people assigned
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A preliminary investigation of the simultaneous effects of cannabidiol and caffeine. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-11-02 Morgan L Ferretti,Noah D Gustin,Caroline M Sokol,C Austin Zamarripa,Matthew T Feldner,Marcel O Bonn-Miller,Jessica G Irons
Caffeine and cannabidiol (CBD) are commonly consumed by the general population, particularly among young adults; however, there is little research on the simultaneous effects of caffeine and CBD. The present study aimed to examine the simultaneous self-reported effects of caffeine and CBD in young healthy adults. Participants (N = 54) who reported daily caffeine use (> 200 mg) attended one experimental
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How executive functioning moderates the relation between implicit alcohol associations and heavy episodic drinking: The roles of planning and working memory. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-11-02 Bonnie H P Rowland,Jianna Iaciofano,Tibor P Palfai
Heavy episodic drinking (HED) is common among college students and poses risks for negative consequences. Evidence suggests that HED is more frequent among those with stronger implicit alcohol associations, and the impact of these implicit associations on drinking may be moderated by executive functioning. This study examined the role of two executive function components-working memory (WM) and planning-as
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Alcohol demand in college students: The roles of athletic involvement and gender. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-10-12 Rebecca Kurnellas, Rose Marie Ward, Elizabeth Taylor, Margaret P Martinetti
College student-athletes represent a high-risk group for heavy alcohol consumption and negative alcohol-related consequences. Although college drinking correlates with access to low-cost alcohol, no study has examined demand, or the relationship between price and consumption, in student-athletes. Furthermore, the prevalence of anxiety, depression, and drinking to cope motives in student-athletes suggest
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Signal processing and machine learning with transdermal alcohol concentration to predict natural environment alcohol consumption. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-10-12 Nathan A Didier, Andrea C King, Eric C Polley, Daniel J Fridberg
Wrist-worn alcohol biosensors continuously and discreetly record transdermal alcohol concentration (TAC) and may allow alcohol researchers to monitor alcohol consumption in participants' natural environments. However, the field lacks established methods for signal processing and detecting alcohol events using these devices. We developed software that streamlines analysis of raw data (TAC, temperature
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A double-blind, randomized, placebo-controlled study of the safety and effects of CBN with and without CBD on sleep quality. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-10-05 Marcel O Bonn-Miller, Matthew T Feldner, Teah M Bynion, Graham M L Eglit, Megan Brunstetter, Maja Kalaba, Ivori Zvorsky, Erica N Peters, Mike Hennesy
The present study sought to determine the effects of cannabinol (CBN) alone and in combination with cannabidiol (CBD) on sleep quality. This was a double-blind, randomized, placebo-controlled study conducted between May and November 2022. Participants were randomized to receive either (a) placebo, (b) 20 mg CBN, (c) 20 mg CBN + 10 mg CBD, (d) 20 mg CBN + 20 mg CBD, or (e) 20 mg CBN + 100 mg CBD for
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Mixed amphetamine salts-extended release (MAS-ER) as a behavioral treatment augmentation strategy for cocaine use disorder: A randomized clinical trial. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-09-21 Kenneth M Carpenter,C Jean Choi,Cale Basaraba,Martina Pavlicova,Daniel J Brooks,Christina A Brezing,Adam Bisaga,Edward V Nunes,John J Mariani,Frances R Levin
Psychosocial interventions remain the primary strategy for addressing cocaine use disorder (CUD), although many individuals do not benefit from these approaches. Amphetamine-based interventions have shown significant promise and may improve outcomes among individuals continuing to use cocaine in the context of behavioral interventions. One hundred forty-five adults (122 males) who used cocaine a minimum
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Stereotype threat contributes to poorer recall performance among undergraduate students with problematic drinking patterns. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-09-21 Samantha Johnstone,Kesia Courtenay,Todd A Girard
Stereotype threat occurs when individuals from stigmatized groups feel they are expected to conform to a negative stereotype associated with their group. Studies show that activating stereotype threat can impair performance on cognitive tasks in various marginalized groups. Individuals with problematic alcohol use are subject to stigmatized views related to cognitive abilities and socialization skills;
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Executive functions and behavioral economic demand for cannabis among young adults: Indirect associations with cannabis consumption and cannabis use disorder. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-09-21 Sophie G Coelho,Christian S Hendershot,Elizabeth R Aston,Anthony C Ruocco,Lena C Quilty,Rachel F Tyndale,Jeffrey D Wardell
Behavioral economic demand for cannabis is robustly associated with cannabis consumption and cannabis use disorder (CUD). However, few studies have examined the processes underlying individual differences in the relative valuation of cannabis (i.e., demand). This study examined associations between executive functions and cannabis demand among young adults who use cannabis. We also examined indirect
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Response-contingent cocaine increases the reinforcing effectiveness of social contact. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-09-14 Mark A Smith,Jacob D Camp,Alexandra N Johansen,Justin C Strickland
Epidemiological studies report a high concordance rate of drug use within groups, suggesting an interplay between drug reinforcement and social cohesion. Preclinical studies reveal that (a) contingent access to a social partner increases cocaine intake and (b) experimenter-delivered cocaine increases the reinforcing effects of social contact. The purpose of this study was to determine if response-contingent
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The association between exercise and prescription opioid misuse: A scoping review. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-08-21 Whitney S Córdoba-Grueso, Paola P Mattey-Mora, Chen Chen, Karla I Galaviz, Maria A Parker
Exercise prevents chronic diseases and modulates pain. People experiencing pain often use opioids for relief, increasing the risk of prescription opioid misuse. Nonetheless, exercise may influence prescription opioid misuse through the release of endorphins or induced injury-related pain. We aimed to summarize the existing literature on the association between exercise and prescription opioid misuse
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Extending contingency management for smoking cessation to patients with or at risk for cardiovascular disease: A preliminary trial of a home-based intervention. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-08-21 Sulamunn R M Coleman, Stephen T Higgins, Joshua M Smyth, Brian L Rodriguez, Megala Loganathan, Diann E Gaalema
Cigarette smoking puts individuals with or at risk for developing cardiovascular disease (CVD) in jeopardy of experiencing a major cardiovascular event. Contingency management (CM) for smoking cessation is an intervention wherein financial incentives are provided contingent on biochemically verified smoking abstinence. Conventional CM programs typically require frequent clinic visits for abstinence
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Cocaine and heroin interact differently with nondrug reinforcers in a choice situation. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-08-03 Madeline M Beasley,Sarah Amantini,Tommy Gunawan,Alan Silberberg,David N Kearns
The present study used a rat choice model to test how cocaine or heroin economically interacted with two different nondrug reinforcers along the substitute-to-complement continuum. In Experiment 1, the nondrug alternative was the negative reinforcer timeout-from-avoidance (TOA)-that is, rats could press a lever to obtain a period of safety from footshock. One group of rats chose between cocaine and
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Nicotine deprivation amplifies attentional bias toward racial discrimination stimuli in African American adults who smoke cigarettes. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-08-03 Mariel S Bello,Yi Zhang,Junhan Cho,Matthew G Kirkpatrick,Raina D Pang,Jason A Oliver,Monica Webb Hooper,Jessica L Barrington-Trimis,Jasjit S Ahluwalia,Adam M Leventhal
High smoking prevalence and low quit smoking rates among African American adults are well-documented, but poorly understood. We tested a transdisciplinary theoretical model of psychopharmacological-social mechanisms underlying smoking among African American adults. This model proposes that nicotine's acute attention-filtering effects may enhance smoking's addictiveness in populations unduly exposed
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A preliminary characterization of cannabis oil use and vaporization among individuals who use for medical purposes: A pilot study. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-07-31 Jacqueline E Smith, Elizabeth R Aston, Samantha G Farris
Little is known about the naturalistic use of cannabis oil vaporization, a high-potency product with the ability to be administered discreetly. This pilot study evaluated the feasibility of utilizing a "smart" vaporizer and application to assess the timing, frequency, socioenvironmental factors, and substance use involved in cannabis oil vaporization. Adults with a medical cannabis registration card
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Combustible cigarette smokers versus e-cigarette dual users among Latinx individuals: Differences in alcohol and drug use severity. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-07-20 Michael J Zvolensky,Justin M Shepherd,Bryce K Clausen,Brooke Y Redmond,Virmarie Correa-Fernández,Joseph W Ditre
The Latinx population in the United States (U.S.) experiences significant tobacco and other substance use-related health disparities. Yet, little is known about the couse of combustible cigarettes and e-cigarettes (dual use) in relation to substance use behavior among Latinx smokers. The present investigation compared English-speaking Latinx adults living in the United States who exclusively smoke
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Menstrual Phase Identification Questionnaire (MPIQ): Development and validation of a cross-sectional survey to identify follicular and luteal phases. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-07-13 Alicia M Allen,Michelle Valenti,Linnea B Linde-Krieger,Kristina Medvescek,Leslie V Farland
Evidence continues to accumulate on the influence of the menstrual phase on several biobehavioral outcomes (e.g., substance misuse). Expansion of this knowledge is limited due to the burdensomeness of accurate menstrual phase assessment. Thus, we sought to create and validate a questionnaire that can be used as a stand-alone item within low-resource settings and numerous study designs (e.g., cross-sectional)
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Support for incentive-sensitization theory in adolescent ad libitum smokers using ecological momentary assessment. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-06-29 Samantha J Klaver, Robert D Dvorak, Ardhys N De Leon, Emily K Burr, Angelina V Leary, Emma R Hayden, Roselyn Peterson, Quinn Allen, Chad J Gwaltney
The incentive-sensitization theory (IST) has emerged as a potentially useful theory in explaining substance addiction. IST postulates that the prolonged use of a substance can alter neural systems that are often involved in incentive motivation and reward processes, leading to an increased "sensitization" to the substance and associated stimuli. However, this increased sensitization is thought to mediate
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Drinking alcohol appears to have no impact on self-perceptions of morality, aggressiveness, or intelligence. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-06-26 Mariola Paruzel-Czachura,Agnieszka Sorokowska,Americus Reed
People generally perceive themselves as moral but does this tendency change after alcohol consumption? In the current research, we tested whether alcoholic intoxication affects self-assessments of morality (i.e., the self-importance of moral identity and the moral self-concept), and we also tested self-assessment of aggressiveness and intelligence. We conducted a preregistered laboratory experiment
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Expectancy of alcohol analgesia moderates perception of pain relief following acute alcohol intake. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-06-26 Casey Alexander,Nicholas J Bush,John K Neubert,Michael Robinson,Jeff Boissoneault
Although laboratory studies indicate alcohol reduces pain intensity and increases pain threshold, these effects likely do not completely explain perceived pain relief from alcohol intake. In this study, we tested expectancy of alcohol analgesia (EAA) as a moderator of subjective pain relief following oral alcohol challenge in individuals with and without chronic orofacial pain. Social drinkers (N =
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Longitudinal associations between anxiety sensitivity and substance use in adolescents: Mediation by depressive affect. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-06-26 Casey R Guillot,Raina D Pang,Joseph R Vilches,Macey L Arnold,Jonathan O Cajas,Alexandria M Alemán,Adam M Leventhal
Though anxiety sensitivity (AS)-fear of anxiety-related experiences-is primarily tied to anxiety vulnerability, AS has also been prospectively associated with general negative affect and depression. Furthermore, depression has been longitudinally associated with different forms of substance use, and some AS subfactors (e.g., cognitive concerns) have been associated more consistently with depression
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Baseline affective symptomatology moderates acute subjective effects of high potency THC and CBD cannabis concentrates. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-06-08 Renée Martin-Willett,Carillon J Skrzynski,Hollis C Karoly,Joshua S Elmore,L Cinnamon Bidwell
Highly potent cannabis concentrates are widely available and associated with affective disturbance and cannabis use disorder. Little is known about the effects of concentrated Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) and their relationship to long-term affect. We explored how baseline affective symptoms (anxiety and depression) relate to acute (i.e., immediate or short-term) subjective mood
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Posttraumatic stress and distress tolerance in relation to opioid misuse and dependence among trauma-exposed adults with chronic pain. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-06-01 Brienna M Fogle,Katherine Kabel,Justin M Shepherd,Andrew H Rogers,Anka A Vujanovic,Michael J Zvolensky
Posttraumatic stress symptoms have been associated with opioid misuse and dependence among adults with chronic pain. Lower levels of perceived distress tolerance (i.e., perceived ability to withstand negative emotional states) have been independently associated with posttraumatic stress symptoms and opioid-related problems among nonchronic pain samples. However, there has not been a test of whether
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Loss aversion predicts cigarette smoking status across levels of sociodemographic characteristics. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-25 Eric A Thrailkill, Michael DeSarno, Stephen T Higgins
Loss aversion (LA) is a tendency to be more sensitive to potential losses relative to similar gains. Low LA is associated with increased risk for cigarette smoking and use of other substances. Previous studies of LA and smoking risk controlled for potentially confounding influences of sociodemographic characteristics associated with smoking risk. The present study replicates these earlier observations
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Examining the validity of the addictions neuroclinical assessment domains in a crowdsourced sample of adults with current alcohol use. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-25 Victoria R Votaw, Cassandra L Boness, Elena R Stein, Ashley L Watts, Kenneth J Sher, Katie Witkiewitz
Several dimensional frameworks for characterizing heterogeneity in alcohol use disorder (AUD) have been proposed, including the Addictions Neuroclinical Assessment (ANA). The ANA is a framework for assessing individual variability within AUD across three domains corresponding to the proposed stages of the addiction cycle: reward (binge-intoxication stage), negative emotionality (withdrawal-negative
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Lumateperone for treatment of psychotic symptoms in Lewy body disease: A case report. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-25 Adam M Bied, Susan W Njuguna, Ritvij M Satodiya
Individuals experiencing Lewy body disease (LBD) are particularly vulnerable to the adverse effects of neuroleptics. This sensitivity has been employed by some authorities as a diagnostic component for this disorder. At present, we do not have any Food and Drug Administration-approved antipsychotic for the management of psychotic symptoms in this condition. We present the first case of an LBD patient
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Conditioned taste avoidance and conditioned place preference induced by the third-generation synthetic cathinone eutylone in female sprague-dawley rats. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-25 Robert A Jones, Shihui Huang, Hayley N Manke, Anthony L Riley
Recently, use of the synthetic cathinone (aka "bath salt") eutylone has risen in the United States and globally. Due to its novelty in drug markets, its affective properties remain largely uninvestigated. In this context, drugs of abuse have both rewarding and aversive effects and understanding these effects, their relative balance, and factors that impact each are important to understanding the likelihood
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Novel methods for the remote investigation of emerging substances: Application to kratom. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-22 Kirsten E Smith,Jeffrey D Feldman,Kelly E Dunn,Christopher R McCurdy,Oliver Grundmann,Albert Garcia-Romeu,Leigh V Panlilio,Jeffrey M Rogers,Abhisheak Sharma,Salma Pont-Fernandez,Marina Kheyfets,David H Epstein
The botanical product commonly called "kratom" is still relatively novel to the United States. Like other natural products marketed as supplements, kratom is highly variable, both in terms of the alkaloids naturally occurring in kratom leaves and in terms of processing and formulation. Kratom products sold in the United States are not well-characterized, nor are daily use patterns among regular users
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Current suicide risk, but not lifetime history of attempted suicide, predicts treatment response to low-dose ketamine infusion: Post Hoc analysis of adjunctive ketamine study of Taiwanese patients with treatment-resistant depression. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-18 Wei-Chen Lin, Tung-Ping Su, Cheng-Ta Li, Shih-Jen Tsai, Pei-Chi Tu, Ya-Mei Bai, Mu-Hong Chen
Whether current suicide risk or a history of attempted suicide is related to the antidepressant effect of a low-dose ketamine infusion remains unclear. In total, 47 patients with treatment-resistant depression (TRD), including 32 with low current suicide risk and 15 with moderate or high current suicide risk, were randomized to groups receiving a low-dose ketamine infusion of either 0.2 or 0.5 mg/kg
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Behavioral mechanisms of oxycodone's effects in female and male rats: Reinforcement delay and impulsive choice. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-18 Ryan C Blejewski, Justin T Van Heukelom, Jeremy S Langford, Katelyn H Hunt, Isabelle R Rinkert, Thomas J Wagner, Raymond C Pitts, Christine E Hughes
μ-Opioid agonists (e.g., morphine) typically increase impulsive choice, which has been interpreted as an opioid-induced increase in sensitivity to reinforcement delay. Relatively little research has been done with opioids other than morphine (e.g., oxycodone), or on sex differences in opioid effects, on impulsive choice. The present study investigated the effects of acute (0.1-1.0 mg/kg) and chronic
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Associations between alcohol demand, delayed reward discounting, and high-intensity drinking in a diverse emerging adult sample. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-15 Ulysses C Savage,James MacKillop,James G Murphy
The high-intensity drinking threshold (HID; 8+/10+ drinks for women/men) is more strongly associated with significant alcohol-related health consequences than the more common heavy episodic drinking threshold (HED; 4+/5+ drinks for women/men). Behavioral economic measures of alcohol reward value (demand) and delayed reward discounting (DRD) have shown associations with other alcohol-related risk behaviors
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Temporal reliability and stability of delay discounting: A 2-year repeated assessments study of the Monetary Choice Questionnaire. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-15 Justin C Strickland,Brett W Gelino,Jill A Rabinowitz,Magdalene R Ford,Lauren Dayton,Carl Latkin,Derek D Reed
The Monetary Choice Questionnaire (MCQ) is one of the most commonly used measures to assess delay discounting of reward. Reliable measurement by the MCQ is necessary for use in experimental settings or prognostic validity within clinical contexts. The present analysis expands prior work to evaluate temporal reliability and stability over an extended period, including repeated measurements, a larger
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Effects of naltrexone on amphetamine choice in rhesus monkeys and rats. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-15 Hannah L Robinson,Megan Jo Moerke,Matthew L Banks,S Stevens Negus
Clinical amphetamine use is constrained by high abuse potential, and amphetamine use disorder is a persistent clinical problem with no approved medications for its treatment. The opioid antagonist naltrexone has been reported to reduce some abuse-related effects of amphetamine. This study used an amphetamine-versus-food choice procedure in rhesus monkeys and rats to test the hypothesis that naltrexone
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Pain interference among adult dual combustible and electronic tobacco users in terms of perceived barriers for quitting. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-11 Lorra Garey,Tanya Smit,Andre Bizier,Brooke Y Redmond,Joseph W Ditre,Andrew H Rogers,Jafar Bakhshaie,Pamella Nizio,Michael J Zvolensky
Electronic cigarette (e-cigarette) use has become increasingly common among combustible cigarette users, and dual use may represent a more severe type of nicotine addiction. Experiencing pain is one prevalent domain that may be important to understand quit processes and behavior among dual users. Although most past research on pain and nicotine/tobacco has focused on combustible cigarette use, initial
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Modeling the value-based decision to consume alcohol in response to emotional experiences. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-11 Jonas Dora,Amber Copeland,Matt Field,Kevin M King
Evidence for negative reinforcement of alcohol use is mixed; one possible explanation for this is that people make value-based decisions whether to regulate their emotions via alcohol or an alternative, and only drink-to-cope when alcohol's reinforcing value is larger than that of available alternatives. If this is the case, immediately following a negative emotional event, the value for alcohol should
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Clinically meaningful individual differences in opioid withdrawal expression. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-11 Orrin D Ware,Kelly E Dunn
Opioid use disorder (OUD) is a significant public health concern. An individual with an OUD may experience withdrawal after stopping opioid use. There has been limited exploration of the individual differences in withdrawal expression. This study expands understanding of this issue by examining the presence and frequency at which persons who have ever had opioid withdrawal have experienced different
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Changing the paradigm in treatment-resistant depression: A review of long-term efficacy and tolerability of esketamine nasal spray. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-01 Jesús Herrera-Imbroda
Treatment-resistant depression (TRD) is a major public health problem worldwide. There are currently five strategies for its treatment: optimization, change, combination, augmentation, and somatic therapies. However, many of these therapies are not fully effective, are not accessible, or have a significant number of side effects. Esketamine nasal spray has recently been approved, in combination with
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Exponentiated model of drug demand is preferred over exponential models in people with daily/near daily cannabis use. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-01 Preston T Tolbert,Miranda P Ramirez,Justin C Strickland,Joshua A Lile,William W Stoops,Brady J Stamper,Caroline B Sumner,Michael J Wesley
Cannabis use is a growing health concern emphasizing the need to better understand the complexities of drug choice in people with daily/near daily cannabis use. Hypothetical purchasing tasks provide a means to collect data on drug consumption behavior without requiring drug administration and have been used to isolate behavioral economic factors of choice, including facets of drug demand in substance
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Use of cannabidiol (CBD) for the treatment of cognitive impairment in psychiatric and neurological illness: A narrative review. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-05-01 Rachel Ortiz,Sergio Rueda,Patricia Di Ciano
Cannabidiol (CBD) is one of the major phytocannabinoids present in the cannabis plant, with no acute psychotropic effects and a favorable safety and abuse liability profile. Animal and limited controlled human studies have demonstrated CBD to have analgesic, anxiolytic, anti-inflammatory, antipsychotic, and anticonvulsant effects, to name a few possible indications. There is growing evidence for the
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Are the attention checks embedded in delay discounting tasks a valid marker for data quality? Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-03-23 Shahar Almog,Andrea Vásquez Ferreiro,Meredith S Berry,Jillian M Rung
To ensure good quality delay discounting (DD) data in research recruiting via crowdsourcing platforms, including attention checks within DD tasks have become common. These attention checks are typically identical in format to the task questions but have one sensical answer (e.g., "Would you prefer $0 now or $100 in a month?"). However, the validity of these attention checks as a marker for DD or overall
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Development of two novel treatments to promote smoking cessation: Savor and retrieval-extinction training pilot clinical trial findings. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-03-13 Amanda M Palmer, Matthew J Carpenter, Nathaniel L Baker, Brett Froeliger, Madeline G Foster, Eric L Garland, Michael E Saladin, Benjamin A Toll
Despite decades of progress, cigarette smoking remains a significant contributor to disease burden. This effect is especially pronounced for specific priority populations, such as individuals who live in rural communities, in that the burden of tobacco smoking is greater among these groups than in urban areas and the general population. The present study aims to evaluate the feasibility and acceptability
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Presentation matters: Effects of cigarette purchase task design on systematic data and purchasing behavior. Exp. Clin. Psychopharmacol. (IF 2.3) Pub Date : 2023-03-06 Devin C Tomlinson, Roberta Freitas-Lemos, Allison N Tegge, Yu-Hua Yeh, Candice L Dwyer, Jeffrey S Stein, Warren K Bickel
Hypothetical purchase tasks (HPTs) are effective tools for evaluating participants' demand for substances. The present study evaluated the effect of task presentation on producing unsystematic data and purchasing behavior in a sample of individuals who smoke cigarettes. Participants (n = 365) were recruited from Amazon Mechanical Turk and randomly assigned to complete two of three HPT presentations: