-
Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway Pharmacol. Rep (IF 4.4) Pub Date : 2024-03-18 Jongtae Roh, Jun-Pil Jang, Taehoon Oh, Jihong Kim, Byeongsan Lee, Young-Soo Hong, Jae-Hyuk Jang, Sung-Kyun Ko
-
Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy Pharmacol. Rep (IF 4.4) Pub Date : 2024-03-18 Mahdi Vajdi, Arash Karimi, Shirin Hassanizadeh, Mahdieh Abbasalizad Farhangi, Mohammad Bagherniya, Gholamreza Askari, Basil D. Roufogalis, Neal M. Davies, Amirhossein Sahebkar
-
Liquid chromatography–tandem mass spectrometry method for mycophenolic acid and its glucuronide determination in saliva samples from children with nephrotic syndrome Pharmacol. Rep (IF 4.4) Pub Date : 2024-03-15
Abstract Background Saliva sampling is one of the methods of therapeutic drug monitoring for mycophenolic acid (MPA) and its metabolite, mycophenolic acid glucuronide (MPAG). The study describes the liquid chromatography tandem mass spectrometry (LC–MS/MS) method developed for saliva MPA and MPAG determination in children with nephrotic syndrome. Methods The mobile phase consisted of methanol and water
-
Further proof on the role of accumbal nNOS in cocaine-seeking behavior in rats Pharmacol. Rep (IF 4.4) Pub Date : 2024-03-14 Małgorzata Frankowska, Irena Smaga, Kinga Gawlińska, Renata Pieniążek, Małgorzata Filip
-
Are there sex differences in oxytocin and vasopressin V1a receptors ligand binding affinities? Pharmacol. Rep (IF 4.4) Pub Date : 2024-03-13 Jack H. Taylor, H. Elliott Albers
-
Transcriptome analysis of an AKT inhibitor-resistant endometrial cancer cell line Pharmacol. Rep (IF 4.4) Pub Date : 2024-03-13 Takafumi Onishi, Tsuyoshi Takashima, Kazuki Shibahara, Shoji Takagi, Shinichi Tanaka, Michihiro Mori, Hirokazu Odashima, Yukihiko Osawa, Manabu Hattori
-
Mechanisms of norcantharidin against renal tubulointerstitial fibrosis Pharmacol. Rep (IF 4.4) Pub Date : 2024-03-12 Qin-Su Yun, Yu-Xin Bao, Jie-Bing Jiang, Qian Guo
-
Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery Pharmacol. Rep (IF 4.4) Pub Date : 2024-03-08 Zhaohui Liu, Fengming Luo, Juan Zhao, Weinan Chen, Wei Gao, Zhou Zhou
-
Cannabinoids in the treatment of glioblastoma Pharmacol. Rep (IF 4.4) Pub Date : 2024-03-08 Barbara Buchalska, Katarzyna Kamińska, Maja Owe-Larsson, Agnieszka Cudnoch-Jędrzejewska
-
The protective effects of statins in traumatic brain injury Pharmacol. Rep (IF 4.4) Pub Date : 2024-03-07 Safoora Pordel, Alice P. McCloskey, Wael Almahmeed, Amirhossein Sahebkar
-
The study of platelet aggregation using a microtiter plate reader ‒ methodological considerations Pharmacol. Rep (IF 4.4) Pub Date : 2024-03-05 Magdalena Boncler, Jacek Golański
-
Diagnostic, prognostic, and therapeutic potential of exosomal microRNAs in renal cancer Pharmacol. Rep (IF 4.4) Pub Date : 2024-02-22 Xiaodong Yu, Zhongbo Du, Pingyu Zhu, Bo Liao
Renal cell carcinoma (RCC) arises from the tubular epithelial cells of the nephron. It has the highest mortality rate among urological cancers. There are no effective therapeutic approaches and no non-invasive biomarkers for diagnosis and follow‐up. Thus, suitable novel biomarkers and therapeutic targets are essential for improving RCC diagnosis/prognosis and treatment. Circulating exosomes such as
-
Lipid-lowering drugs and cancer: an updated perspective Pharmacol. Rep (IF 4.4) Pub Date : 2024-02-01 Azin Alizadehasl, Maryam Sadat Alavi, Shabnam Boudagh, Mohaddeseh Sadat Alavi, Somaye Mohebi, Leila Aliabadi, Mahsa Akbarian, Parisa Ahmadi, Massimo R. Mannarino, Amirhossein Sahebkar
-
Safety of non-standard regimen of systemic steroid therapy in patients with Graves’ orbitopathy: a single-centre experience Pharmacol. Rep (IF 4.4) Pub Date : 2024-01-26 Nadia Sawicka-Gutaj, Dawid Gruszczyński, Natalia Zawalna, Kacper Nijakowski, Agnieszka Skiba, Mateusz Pochylski, Jerzy Sowiński, Marek Ruchała
-
The role of bidirectional communication between the adipokines and the endogenous opioid system in an experimental mouse model of colitis-associated colorectal cancer Pharmacol. Rep (IF 4.4) Pub Date : 2024-01-18 Agata Szymaszkiewicz, Mikołaj Mierzejewski, Emilia Januszkiewicz, Weronika Machelak, Marcin Talar, Jakub Włodarczyk, Mikołaj Świerczyński, Radzisław Kordek, Jakub Fichna, Marta Zielińska
-
Reno-protective effect of protocatechuic acid is independent of sex-related differences in murine model of UUO-induced kidney injury Pharmacol. Rep (IF 4.4) Pub Date : 2024-01-12
Abstract Background Obstructive nephropathy is a condition often caused by urinary tract obstruction either anatomical (e.g., tumors), mechanical (e.g., urolithiasis), or compression (e.g., pregnancy) and can progress to chronic kidney disease (CKD). Studies have shown sexual dimorphism in CKD, where males were found to have a more rapid decline in kidney function following kidney injury compared to
-
Contribution of changes in the orexin system and energy sensors in the brain in depressive disorder - a study in an animal model Pharmacol. Rep (IF 4.4) Pub Date : 2024-01-09
Abstract Background Maternal elevated glucocorticoid levels during pregnancy can affect the developing fetus, permanently altering the structure and function of its brain throughout life. Excessive action of these hormones is known to contribute to psychiatric disorders, including depression. Materials The study was performed in a rat model of depression based on prenatal administration of dexamethasone
-
Network analysis of monoamines involved in anxiety-like behavior in a rat model of osteoarthritis Pharmacol. Rep (IF 4.4) Pub Date : 2024-01-05 Jakub Mlost, Magdalena Białoń, Marta Kędziora, Agnieszka Wąsik, Żaneta Michalec, Katarzyna Starowicz
-
The impact of brivaracetam on cognitive processes and anxiety in various experimental models Pharmacol. Rep (IF 4.4) Pub Date : 2024-01-05 Ewa Zwierzyńska, Bogusława Pietrzak
-
Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats Pharmacol. Rep (IF 4.4) Pub Date : 2024-01-03 Agata Cieslik-Starkiewicz, Karolina Noworyta, Joanna Solich, Agata Korlatowicz, Agata Faron-Górecka, Rafal Rygula
-
Effect of bisphosphonates and statins on the in vitro radiosensitivity of breast cancer cell lines Pharmacol. Rep (IF 4.4) Pub Date : 2023-12-27 Larry Bodgi, Jolie Bou-Gharios, Joyce Azzi, Rafka Challita, Charbel Feghaly, Khanom Baalbaki, Hussein Kharroubi, Fatima Chhade, Fady Geara, Wassim Abou-Kheir, Zeina Ayoub
-
Weighted gene co-expression network analysis for hub genes in colorectal cancer Pharmacol. Rep (IF 4.4) Pub Date : 2023-12-27 Zheng Xu, Jianing Wang, Guosheng Wang
-
New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study Pharmacol. Rep (IF 4.4) Pub Date : 2023-12-11 Jakub Włodarczyk, Julia Krajewska, Marcin Talar, Łukasz Szeleszczuk, Agata Gurba, Szymon Lipiec, Przemysław Taciak, Remigiusz Szczepaniak, Izabela Młynarczuk-Biały, Jakub Fichna
-
Impact of metformin on hypothalamic–pituitary–thyroid axis activity in women with autoimmune and non-autoimmune subclinical hypothyroidism: a pilot study Pharmacol. Rep (IF 4.4) Pub Date : 2023-12-05 Robert Krysiak, Karolina Kowalcze, Bogusław Okopień
-
Introduction to the thematic collection "Psychedelic Medicine: Therapeutic Applications and Implications for Future Research". Pharmacol. Rep (IF 4.4) Pub Date : 2023-12-01 Krystyna Gołembiowska
-
AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-29 Paweł Marzęda, Paula Wróblewska-Łuczka, Magdalena Florek-Łuszczki, Agnieszka Góralczyk, Jarogniew J. Łuszczki
-
Imperatorin interacts additively with novel antiseizure medications in the mouse maximal electroshock-induced seizure model: an isobolographic transformation Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-28 Jarogniew J. Łuszczki, Ewelina Kochman-Moskal, Hubert Bojar, Magdalena Florek-Łuszczki, Krystyna Skalicka-Woźniak
-
Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-23 Azam Hosseinzadeh, Mohammad Hossein Pourhanifeh, Shiva Amiri, Mohammad Sheibani, Rana Irilouzadian, Russel J. Reiter, Saeed Mehrzadi
-
Can research on entactogens contribute to a deeper understanding of human sexuality? Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-08 Justyna Holka-Pokorska
-
Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-07 Barbara Chruścicka-Smaga, Agata Machaczka, Bernadeta Szewczyk, Andrzej Pilc
-
The possible place for psychedelics in pharmacotherapy of mental disorders Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-07 Adam Wojtas
Since its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting the lives of millions of patients. While crucial in the history of drug development, recent studies undermine the effectiveness of currently used antidepressant drugs in comparison to placebo, emphasizing the long time it takes to initiate the therapeutic
-
Mindfulness meditation and psychedelics: potential synergies and commonalities Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-06 Paweł Holas, Justyna Kamińska
There has been increasing scientific and clinical interest in studying psychedelic and meditation-based interventions in recent years, both in the context of improving mental health and as tools for understanding the mind. Several authors suggest neurophysiological and phenomenological parallels and overlaps between psychedelic and meditative states and suggest synergistic effects of both methods.
-
Unraveling snake venom phospholipase A2: an overview of its structure, pharmacology, and inhibitors Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-06 Ganesh H. Sampat, Kashinath Hiremath, Jagadeesh Dodakallanavar, Vishal S. Patil, Darasaguppe R. Harish, Prakash Biradar, Rashmi K. Mahadevamurthy, Manish Barvaliya, Subarna Roy
-
Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT2C receptor in the mouse brain Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-03 Magdalena Zaniewska, Natalia Alenina, Sebastian Fröhler, Wei Chen, Michael Bader
-
Mitragynine inhibits hippocampus neuroplasticity and its molecular mechanism Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-04 Suleiman Yunusa, Zurina Hassan, Christian P. Müller
-
Serum levels of biomarkers that may link chronic obstructive pulmonary disease and depressive disorder Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-03 Elżbieta Małujło-Balcerska, Tadeusz Pietras, Witold Śmigielski
-
Therapeutic, diagnostic and prognostic values of TRIM proteins in prostate cancer Pharmacol. Rep (IF 4.4) Pub Date : 2023-11-03 Xiaojiang Li, Yuzhuo Bai, Ke Feng, Zhendong Chu, Haijun Li, Zhicheng Lin, Lin Tian
-
Psychedelics action and schizophrenia Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-30 Marzena Maćkowiak
Psychedelics are compounds acting by serotonin 5-hydroxytryptamine (5-HT)2A receptor activation and induce several behavioral responses. They are of special interest because of their positive effects on neuropsychiatric disorders (depression and posttraumatic stress disorder). However, several findings revealed that some psychedelic actions are similar to symptoms observed in schizophrenia (psychosis
-
Exploring the therapeutic potential of natural compounds modulating the endocannabinoid system in various diseases and disorders: review Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-31 Gidion Wilson, Lingling Yang, Xiaojuan Su, Shuqin Ding, Liuyan Li, Youyue Yang, Xiaoying Wang, Weibiao Wang, Yuping Sa, Yue Zhang, Jianyu Chen, Xueqin Ma
-
Preclinical models of treatment-resistant depression: challenges and perspectives Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-26 Magdalena Kolasa, Agata Faron-Górecka
-
Cardiovascular safety of psychedelic medicine: current status and future directions Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-24 Agnieszka Wsół
-
Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-24 Artur Pałasz, Julia Kistowska, Aleksandra Suszka-Świtek, Marek Krzystanek, Iwona Błaszczyk, Itiana Castro Menezes, Łukasz Filipczyk, Katarzyna Bogus
-
Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-18 Urszula Florczyk-Soluch, Katarzyna Polak, Reece Sabo, Alicja Martyniak, Jacek Stępniewski, Józef Dulak
-
The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-17 Anna Haduch, Ewa Bromek, Wojciech Kuban, Agnieszka Basińska-Ziobroń, Przemysław J. Danek, Natalia Alenina, Michael Bader, Władysława A. Daniel
-
Development and characterization of a temozolomide-loaded nanoemulsion and the effect of ferrocene pre and co-treatments in glioblastoma cell models Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-14 Jeferson Gustavo Henn, Matheus Bernardes Ferro, Gabriel Antonio Lopes Alves, Flávia Pires Peña, João Vitor Raupp de Oliveira, Bárbara Müller de Souza, Leonardo Fonseca da Silva, Victória Rapack Jacinto Silva, Ana Carolina Silva Pinheiro, Luiza Steffens Reinhardt, Ana Moira Morás, Michael Nugent, Ricardo Gomes da Rosa, Tanira Alessandra Silveira Aguirre, Dinara Jaqueline Moura
-
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic–clonic seizure model: an isobolographic transformation Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-11 Jarogniew J. Łuszczki, Hubert Bojar, Katarzyna Jankiewicz, Magdalena Florek-Łuszczki, Jarosław Chmielewski, Krystyna Skalicka-Woźniak
-
Effects of N-acetylcysteine and acetyl-l-carnitine on acute PTZ-induced seizures in larval and adult zebrafish Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-09 Rafael Chitolina, Carlos G. Reis, Thailana Stahlhofer-Buss, Amanda Linazzi, Radharani Benvenutti, Matheus Marcon, Ana P. Herrmann, Angelo Piato
-
Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-07 Daniele Romani Miksza, Giuliana Regina Biazi, Isabele Gonçalves Frasson, Winny Beatriz de Souza Galia, Laura Socio Ferraz, Brenda Francisconi Diaz, Mirian Ayumi Kurauti, Carine Marmentini, Cecília Edna Mareze-Costa, Sidney Barnabé Peres, Priscila Cassolla, Gisele Lopes Bertolini, Roberto Barbosa Bazotte, Helenir Medri de Souza
-
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells Pharmacol. Rep (IF 4.4) Pub Date : 2023-10-05 Joanna Kopecka, Alessandra Barbanente, Daniele Vitone, Fabio Arnesano, Nicola Margiotta, Paola Berchialla, Mauro Niso, Chiara Riganti, Carmen Abate
-
Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet Pharmacol. Rep (IF 4.4) Pub Date : 2023-09-21 Paulina Kleniewska, Rafał Pawliczak
-
Investigating the potential effects of α-synuclein aggregation on susceptibility to chronic stress in a mouse Parkinson’s disease model Pharmacol. Rep (IF 4.4) Pub Date : 2023-09-19 Anna Alwani, Katarzyna Maziarz, Gabriela Burda, Monika Jankowska-Kiełtyka, Adam Roman, Gabriela Łyszczarz, Safak Er, Justyna Barut, Olga Barczyk-Woźnicka, Elżbieta Pyza, Grzegorz Kreiner, Irena Nalepa, Piotr Chmielarz
-
Effervescent tablet-assisted deep eutectic solvent based on magnetic nanofluid for liquid phase microextraction of tyrosine kinase inhibitors in plasma samples by high-performance liquid chromatography Pharmacol. Rep (IF 4.4) Pub Date : 2023-09-17 Khosrou Abdi, Maryam Ezoddin, Laleh Adlnasab, Bahar Aziz Kabiri, Mohammad Ali Karimi, Somaye Behnamipour, Houman Alimoradi
-
HDAC3 inhibition protects against peripheral and central alterations in an animal model of obesity Pharmacol. Rep (IF 4.4) Pub Date : 2023-09-12 Franciéle Romero Machado, Silvana Peterini Boeira, Vandreza Cardoso Bortolotto, Stífani Machado Araujo, Márcia Rósula Poetini, Cristini Escobar Viana, Marina Prigol, Leandro Cattelan Souza, Marcelo Gomes de Gomes
-
Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen–glucose deprivation condition Pharmacol. Rep (IF 4.4) Pub Date : 2023-09-11 Ming-Chia Chu, Wei-Chang Mao, Han-Fang Wu, Yun-Chi Chang, Ting-I Lu, Chi-Wei Lee, Yueh-Jung Chung, Tsung-Han Hsieh, Hsun-Shuo Chang, Yih-Fung Chen, Chia-Hsien Lin, Chih-Wei Tang, Hui-Ching Lin
-
The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study Pharmacol. Rep (IF 4.4) Pub Date : 2023-09-13 Wojciech Rogóż, Kinga Mac, Aleksandra Owczarzy, Karolina Kulig, Jadwiga Pożycka, Małgorzata Maciążek-Jurczyk
-
Therapeutic implications of phosphorylation- and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration Pharmacol. Rep (IF 4.4) Pub Date : 2023-09-09 Nilima Khakha, Heena Khan, Amarjot Kaur, Thakur Gurjeet Singh
-
Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases Pharmacol. Rep (IF 4.4) Pub Date : 2023-09-06 Mahika Joshi, Priyanka Hiremath, Jeena John, Niraja Ranadive, Krishnadas Nandakumar, Jayesh Mudgal
-
Pten knockout affects drug resistance differently in melanoma and kidney cancer Pharmacol. Rep (IF 4.4) Pub Date : 2023-09-06 Klaudia Brodaczewska, Aleksandra Majewska, Aleksandra Filipiak-Duliban, Claudine Kieda
-
Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis Pharmacol. Rep (IF 4.4) Pub Date : 2023-09-05 Vandita Kakkar, Komal Saini, Kamalinder K. Singh
-
Pharmacologic hyperreactivity of kappa opioid receptors in periaqueductal gray matter during alcohol withdrawal syndrome in rats Pharmacol. Rep (IF 4.4) Pub Date : 2023-09-02 Priscila Vázquez-León, Abraham Miranda-Páez, Hugo Sánchez-Castillo, Bruno A. Marichal-Cancino