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CB2 agonist mitigates cocaine-induced reinstatement of place preference and modulates the inflammatory response in mice. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-12-13 Oualid Abboussi, Zmarak Ahmad Khan, Hind Ibork, Simo S Zulu, William Daniels, Khalid Taghzouti, Tim G Hales
Chronic exposure to cocaine is known to have profound effects on the brain, leading to the dysregulation of inflammatory signalling pathways, the activation of microglia, and the manifestation of cognitive and motivational behavioural impairments. The endocannabinoid system has emerged as a potential mediator of cocaine's deleterious effects. In this study, we sought to investigate the therapeutic
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Discriminative-stimulus effects of cannabidiol oil in Sprague-Dawley rats. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-12-13 Rebecca L Chalmé, Michelle A Frankot, Karen G Anderson
Cannabidiol (CBD) is one of the major centrally active phytocannabinoid components of cannabis, and has been approved by the FDA only for the treatment of seizures associated with three rare disorders. It has also been touted as a potential treatment for anxiety in place of more traditional treatments like benzodiazepines. Although there is some evidence of anxiolytic effects of CBD, its suitability
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Intra-accumbal orexinergic system contributes to the stress-induced antinociceptive behaviors in the animal model of acute pain in rats. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-12-04 Mohammad Nikoohemmat, Danial Farmani, Seyed Mohammadmisagh Moteshakereh, Sakineh Salehi, Laleh Rezaee, Abbas Haghparast
Stress and pain are interleaved at numerous levels - influencing each other. Stress can increase the nociception threshold in animals, long-known as stress-induced analgesia (SIA). Orexin is known as a neuropeptide that modulates pain. The effect of stress on the mesolimbic system in the modulation of pain is known. The role of the intra-accumbal orexin receptors in the modulation of acute pain by
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Minocycline as a potential anxiolytic drug: systematic review and meta-analysis of evidence in murine models. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-11-20 Lia P Iglesias, Nicia Soares, Laila Asth, Fabricio A Moreira, Daniele C Aguiar
Minocycline is a tetracycline antibiotic with off-label use as an anti-inflammatory drug. Because it can cross the blood-brain barrier, minocycline has been proposed as an alternative treatment for psychiatric disorders, in which inflammation plays an important role. However, its beneficial effects on anxiety disorders are unclear. Therefore, we performed a systematic review and meta-analysis to evaluate
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Examination of the mechanisms underlying the discriminative stimulus properties of the atypical antipsychotic amisulpride. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-11-15 Timothy J Donahue, Todd M Hillhouse, Kevin A Webster, Richard Young, Eliseu O De Oliveira, Joseph H Porter
Amisulpride is an atypical benzamide antipsychotic/antidepressant, whose mechanism of action is thought to depend mainly on dopamine D2/3 receptor activity, but also with some serotonin 5-HT2B/7 effects. The present study examined the role of D2/3 receptors and 5-HT2B/7 receptors in amisulpride's discriminative stimulus. Selective agonists and antagonists of the above receptors were tested in adult
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Can we change automatic processes: the influence of social priming on alcohol attentional bias. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-09-13 Stephen A Cantarutti, Emmanuel M Pothos, Eleni Ziori, Katy Tapper
The Stroop Effect has been linked to social concept priming, suggesting that the latter may trigger automatic behaviour aligned with the primed concept. This study examined the effects of social priming on alcohol attentional bias, with a sample of mostly light drinkers; it used a social priming task and an alcohol-Stroop test to measure participants' response times (RTs) before and after they had
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Methodological approach: using a within-subjects design in the marble burying assay. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-09-01 Kaitlyn J Partridge, Ruth Olson, Todd M Hillhouse
In 2016, the National Institutes of Health mandated the use of both male and female mice in funded research. The use of both sexes is an important variable to consider; however, it comes with negative consequences such as increased animal expenses. One way to combat these negatives is to explore the option of using a within-subjects design (repeated measures) in behavioral assays that historically
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Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-09-01 Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sora
The psychostimulant drug methamphetamine (METH) causes euphoria in humans and locomotor hyperactivity in rodents by acting on the mesolimbic dopamine (DA) pathway and has severe abuse and addiction liability. Behavioral sensitization, an increased behavioral response to a drug with repeated administration, can persist for many months after the last administration. Research has shown that the serotonin
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Effects of acute and chronic nicotine administration on probability discounting. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-09-01 Katya A Nolder, Karen G Anderson
Nicotine use is a continuing public health concern. Smokers are more likely to make risky or maladaptive decisions compared to nonsmokers, so the relation between nicotine and risky choice warrants further investigation. Risky choice can be operationally defined as the choice for a larger, uncertain reinforcer over a smaller, certain reinforcer and can be assessed through a probability-discounting
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Anorectic effect of COR659 in a rat model of overeating. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-08-31 Paola Maccioni, Claudia Mugnaini, Mauro A M Carai, Gian Luigi Gessa, Federico Corelli, Giancarlo Colombo
COR659 is a new compound, the action of which is exerted via a dual mechanism: positive allosteric modulation of the GABAB receptor; antagonism or inverse agonism at the cannabinoid CB1 receptor. Recent lines of experimental evidence have indicated that COR659 potently and effectively reduced operant self-administration of and reinstatement of seeking behaviour for a chocolate-flavoured beverage. The
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Zymosan A produces a rapid and sustained antidepressant effect in chronically stressed mice by stimulating hippocampal microglia. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-08-02 Tao Zhu, Bingran Chen, Han Han, Xu Lu, Zhuo Chen, Ting Ye, Hui Zhao, Meng Zheng, Chao Huang
Recent studies had reported that compounds that stimulate microglia could be developed as potential drugs for the treatment of depression due to their reversal effect on depression-like behaviors in chronically stressed mice. Zymosan A is a cell wall preparation of Saccharomyces cerevisiae composed of β-glucans. Based on its immuno-stimulatory activities, we hypothesized that zymosan A might have a
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Estradiol enhances the mirtazapine effects on the expression of cocaine-induced locomotor sensitization in female rats. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-08-02 Susana Barbosa-Méndez, Alberto Salazar-Juárez
Epidemiological studies have mentioned that cocaine use disorder (CUD) has increased in the last decade among women; these show endocrine and reproductive disorders and a high propensity to stress and depression disorders. Mirtazapine-a tetracyclic antidepressant-decreases cocaine-induced locomotor activity and locomotor sensitization in male rats. The objective of this study was to evaluate if estradiol
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Propranolol blocks the unconditioned and conditioned hyperactive effects of methamphetamine in CD-1 mice. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-07-14 Anthony S Rauhut
The present experiment examined the contribution of the β-adrenergic receptor system in mediating the unconditioned (i.e. pharmacological) and conditioned (i.e. learned) hyperactive effects of methamphetamine. To this end, mice underwent an 8-day conditioning procedure involving two different, alternating session types (chamber and home-cage days). On chamber days (1, 3, 5, and 7), mice were injected
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Creatine supplementation protects spatial memory and long-term potentiation against chronic restraint stress. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-07-14 Zahra Bahari, Zohreh Jangravi, Boshra Hatef, Habib Valipour, Gholam Hossein Meftahi
Stress contributes to numerous psychopathologies, including memory impairment, and threatens one's well-being. It has been reported that creatine supplementation potentially influences cognitive processing. Hence, in this study, we examined the effects of creatine supplementation on memory, synaptic plasticity, and neuronal arborization in the CA1 region of the hippocampus in rats under chronic restraint
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The mGlu2/3 agonist LY379268 reduces sucrose taking, seeking, and motivation in male and female rats. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-07-11 Jeffrey William Grimm, Frances Sauter, Derek MacDougall, Emily Spaulding, Kyra Stensgaard, Mason Hardy, Kyle Griffin, Rebecca Marx
The mGlu2/3 receptor agonist LY379268 reduces sucrose-seeking, but not sucrose-taking, in male rats. This study explored the generality of this effect across the sexes. In addition, the effect of the drug on motivation to receive sucrose was assessed.
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Liver tryptophan 2,3-dioxygenase: a determinant of anxiety-like behaviour - studies with chronic nicotine administration in rats. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-07-11 Samina Bano, Humaira Sharif, Faiza Sajid, Sumaiya Binte Hamid, Abdulla A-B Badawy
Deletion of the tryptophan 2,3-dioxygenase (TDO2) gene induces an anxiolytic-like behaviour in mice and TDO inhibition by allopurinol elicits an antidepressant-like effect in rats exposed to restraint stress. Chronic nicotine administration inhibits TDO activity, enhances brain serotonin synthesis and exerts anxiolytic- and antidepressant-like effects in rodent models. There is a strong association
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Serial feature positive and feature negative discrimination learning in a taste avoidance preparation: implications for interoceptive control of behavior. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-07-11 Shihui Huang, Sydney E Cerveny, Anna L Ruprecht, Ethan R Steere, Terry L Davidson, Anthony L Riley
Psychoactive drugs produce interoceptive stimuli that can guide appropriate behaviors by initiating or inhibiting responding.
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The effectiveness of oxytocin in the treatment of stimulant use disorders: a systematic review. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-07-11 Stephen Lee-Cheong, Sacha A Ludgate, Tanisse C M Epp, Christian G Schütz
The purpose of this review is to examine human study evidence on the effectiveness of oxytocin in this patient population. Despite stimulant use disorder being a major public health concern, there are no validated pharmacological treatments. Psychosocial interventions show limited effectiveness especially in the more severe cases of stimulant use disorder, whereas animal models suggest that oxytocin
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The role of lateral habenula NMDA receptors in tramadol-induced conditioning. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-06-30 Arman Hajikarim-Hamedani, Amirhossein Heidari, Mitra-Sadat Sadat-Shirazi, Sarah Mahboubi, Samira Raminfard, Solmaz Khalifeh, Mohammad-Reza Zarrindast
The role of the lateral habenula (LHb) as a hub for receiving and relaying signals from the limbic system to serotonergic, dopaminergic, and norepinephrinergic regions in the brainstem makes this area a critical region in the control of reward and addiction. Behavioral evidence reveals the vital role of the LHb in negative symptoms during withdrawal. In this investigation, we study the role of the
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The M 1 -muscarinic acetylcholine receptor subtype may play a role in learning and memory performance in the hippocampus of neonatal monosodium glutamate-obese rats. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-06-24 Marcelo Florencio Passos Silva, Christian Pereira Rafael, Jeferson Rubens Mamona Silva, Tiago Guardia de Souza E Silva, Rafaela Fadoni Alponti, Patricia Lucio Alves, Maria Regina Lopes Sandoval, Fernando Maurício Francis Abdalla
Here, we investigate the effects of obesity induced by monosodium glutamate (MSG) on cognitive impairment and whether this model induces any alteration in the affinity, density, and subtypes of muscarinic acetylcholine receptors (mAChRs) in rat hippocampus. Healthy rats were used as controls, and MSG-obese rats were selected via the Lee index > 0.300. The effects of MSG-induced obesity on hippocampal
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Menstrual cycle influences on cue-induced smoking cravings and heart rate variability. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-06-24 Ashley Ethier, Laurie Sykes Tottenham, Jyotpal Singh, J Patrick Neary, Jaroslaw Piskorski, Jennifer L Gordon
Women experience greater difficulties in quitting smoking than men, though the hormonal factors contributing to this sex difference remain to be clarified. The current study aimed to examine menstrual cycle effects on smoking cue-induced cravings as well as examine dynamic reproductive hormone change as a potential mediator underlying any cycle effects observed. Twenty-one women who smoke underwent
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Agmatine prevents the memory impairment and the dysfunction of hippocampal GSK-3β and ERK signaling induced by aluminum nanoparticle in mice. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-06-24 Sadegh Izadi, Amin Rezaei, Zahra Esmaili, Roksana Soukhaklari, Maryam Moosavi
The growing usage of aluminum nanoparticles (Al-NP) and their exposure may influence body function. Considering the proposed relationship between Al and the pathogenesis of Alzheimer's disease and the concern about the effect of this nanoparticle on brain health and cognitive function, the use of neuroprotective agents might be helpful. According to the reported neuroprotective effects of agmatine
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Effect of l -Dopa in acute temozolomide-induced cognitive impairment in male mice: a possible antineuroinflammatory role. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-06-24 Alireza Salarinejad, Khadije Esmaeilpour, Mohammad Shabani, Saeideh Jafarinejad-Farsangi, Abbas Pardakhty, Majid Asadi-Shekaari, Meysam Ahmadi-Zeidabadi
Temozolomide is used commonly in the treatment of some types of cancers, but it may also result in cognitive impairments such as memory deficits. l -Dopa, a well known medicine for the central nervous system, has been shown to have positive effects on some cognitive disorders. Here we sought to investigate the effect of l -Dopa on temozolomide-induced cognitive impairments. BALB/c mice were subjected
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Use of drug purchase tasks in medications development research: orexin system regulation of cocaine and drug demand. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-06-22 Justin C Strickland, Kevin W Hatton, Lon R Hays, Abner O Rayapati, Joshua A Lile, Craig R Rush, William W Stoops
Commodity purchase tasks provide a useful method for evaluating behavioral economic demand in the human laboratory. Recent research has shown how responding to purchase tasks for blinded drug administration can be used to study abuse liability. This analysis uses data from a human laboratory study to highlight how similar procedures may be particularly useful for understanding momentary changes in
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Additive effect of histamine and muscimol upon induction of antinociceptive and antidepressant effects in mice. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-05-26 Matin Baghani, Farzan Fathalizade, Fatemeh Khakpai, Soheila Fazli-Tabaei, Mohammad-Reza Zarrindast
We investigated the effects of histamine and GABAA receptor agents on pain and depression-like behaviors and their interaction using a tail-flick test and the forced swimming test (FST) in male mice. Our data revealed that intraperitoneal administration of muscimol (0.12 and 0.25 mg/kg) increased the percentage of maximum possible effect (%MPE) and area under the curve (AUC) of %MPE, indicating an
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The effect of early and long-term propranolol therapy on learning and memory in mice Behav. Pharmacol. (IF 1.6) Pub Date : 2023-05-10 Mehmet Fatih Orhan, Pelin Tanyeri, Mehmet Emin Büyükokuroğlu, Mustafa Büyükavci
Propranolol is the treatment of choice for infantile hemangioma. We investigated the effects of long-term propranolol use in early infancy on learning and memory later in life in mice. At three weeks of age, mice were randomly divided into six experimental groups. Groups 1 and 2 (controls) received only saline for 21 days. Groups 3 and 4 received propranolol (2.5 mg/kg) for 21 days. Groups 5 and 6
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Behavioral effects induced by the cannabidiol analogs HU-502 and HU-556 Behav. Pharmacol. (IF 1.6) Pub Date : 2023-05-10 Débora A. E. Colodete, Nicole R. Silva, João Francisco C. Pedrazzi, Manoela V. Fogaça, Isadora Cortez, Elaine A. Del-Bel, Aviva Breuer, Raphael Mechoulam, Felipe V. Gomes, Francisco S. Guimarães
Cannabidiol is a phytocannabinoid that lacks the psychotomimetic properties of Δ9-tetrahydrocannabinol (THC), the main psychoactive Cannabis sativa component. Cannabidiol has several potential therapeutic properties, including anxiolytic, antidepressant, and antipsychotic; however, cannabidiol has low oral bioavailability, which can limit its clinical use. Here, we investigated if two cannabidiol analogs
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Pharmacological evaluation of lateral habenula and rostromedial tegmental nucleus in the expression of ethanol-induced place preference Behav. Pharmacol. (IF 1.6) Pub Date : 2023-04-27 Sukanya G. Gakare, Rajesh R. Ugale
Although ethanol administration produces a range of physiological effects, the rewarding aspect associated with its consumption is a major contributory factor to its abuse liability. Recently, lateral habenula (LHb) has been shown to be engaged by both rewarding and aversive stimuli. Its major glutamatergic output, the fasciculus retroflexus, projects to the rostromedial tegmental nucleus (RMTg) and
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Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia Behav. Pharmacol. (IF 1.6) Pub Date : 2023-04-01 José Eduardo Suárez Santiago, Gabriel Roldán Roldán, Ofir Picazo
Schizophrenia is a serious neuropsychiatric disorder characterized by the presence of positive symptoms (hallucinations, delusions, and disorganization of thought and language), negative symptoms (abulia, alogia, and affective flattening), and cognitive impairment (attention deficit, impaired declarative memory, and deficits in social cognition). Dopaminergic hyperactivity seems to explain the positive
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Amelioration of cognition impairments in the valproic acid-induced animal model of autism by ciproxifan, a histamine H3-receptor antagonist Behav. Pharmacol. (IF 1.6) Pub Date : 2023-03-30 Farahnaz Taheri, Khadijeh Esmaeilpour, Gholamreza Sepehri, Vahid Sheibani, Majid Asadi Shekari
Autism spectrum disorder is a neurodevelopmental disorder characterized by deficits in social communication and repetitive behavior. Many studies show that the number of cognitive impairmentscan be reduced by antagonists of the histamine H3 receptor (H3R). In this study, the effects of ciproxifan (CPX) (1 and 3 mg/kg, intraperitoneally) on cognitive impairments in rat pups exposed to valproic acid
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The role of L-arginine/NO/cGMP/KATP channel pathway in the local antinociceptive effect of berberine in the rat formalin test Behav. Pharmacol. (IF 1.6) Pub Date : 2023-03-20 Milad Rahemi, Shokooh Mohtadi, Hossein Rajabi Vardanjani, Mohammad Javad Khodayar
Berberine is an isoquinoline alkaloid naturally produced by several types of plants. Berberine has extensive pharmacological effects, such as anti-diabetic, anti-inflammatory, and antioxidant effects. In the current study, we assess the antinociceptive effects of berberine and its association with the l-arginine (l-Arg)/NO/cGMP/KATP channel pathway via intraplantar administration in rats. To examine
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miR-124 Exacerbates depressive-like behavior by targeting Ezh2 to induce autophagy Behav. Pharmacol. (IF 1.6) Pub Date : 2023-04-01 Duan Zeng, Yue Shi, Siyuan Li, Feikang Xu, Weimin Zhu, Huafang Li, Shen He, Qianfa Yuan
On the basis of our previous research, miR-124 and autophagy have been shown to be associated with depression and antidepressant treatment, respectively. However, whether miR-124 is involved in depressive-like behavior and antidepressant efficacy through regulating autophagy remains poorly understood. The chronic unpredictable mild stress (CUMS) depression model in mice was established, and then intraperitoneal
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Effects of Ketanserin, M100907 and Olanzapine on hallucinogenic like action induced by 2,5-dimethoxy-4-methylamphetamine Behav. Pharmacol. (IF 1.6) Pub Date : 2023-04-01 Kaixi Li, Xiaoyan Liu, Mei Zhang, Ruibin Su
2,5-dimethoxy-4-methylamphetamine (DOM) is a kind of hallucinogen of phenylalkylamine. Psychedelic effects mainly include audiovisual synesthesia, complex imagery, disembodiment etc. that can impair control and cognition leading to adverse consequences such as suicide. By now, there are no specific drugs regarding the management of classic hallucinogen use clinically. We evaluated the effects of three
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Antidepressant-like effect of acute dose of Naringin involves suppression of NR1 and activation of protein kinase A/cyclic adenosine monophosphate response element-binding protein/brain-derived neurotrophic factor signaling in hippocampus Behav. Pharmacol. (IF 1.6) Pub Date : 2023-04-01 Guangyao Wang, Haixia Yang, Wenren Zuo, Xiaoyun Mei
Naringin (Nr) has been identified to have antidepressant-like effects through repeated treatment. However, the underlying mechanism of the rapid antidepressant-like effects of Nr was still unclear. The present study used behavioral tests, classic depressive model and pharmacological methods to reveal the rapid antidepressant-like potential of Nr. We found that a single dose of Nr (20 mg/kg) produced
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Modeling spontaneous opioid withdrawal in male and female outbred mice using traditional endpoints and hyperalgesia Behav. Pharmacol. (IF 1.6) Pub Date : 2023-04-01 Abigail L. Brewer, Christina C. Lewis, Liudmyla Eggerman, Alexis Blokker, John A. Burkland, Megan Johnsen, Raymond M. Quock
Opioid withdrawal significantly impacts drug dependence cycles as hyperalgesia associated with withdrawal is often a reason for continued drug use. Animal models of addiction are important tools for studying how drug dependence and withdrawal impact not only normal neurocircuitry but also the effectiveness of potential treatments for dependence and withdrawal. We conducted a study of the time course
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Mitragynine, a primary constituent of kratom reinstates morphine-seeking behaviour in rats Behav. Pharmacol. (IF 1.6) Pub Date : 2023-04-01 Rima Atria Japarin, Norsyifa Harun, Zurina Hassan, Mohammed Shoaib
Mitragynine (MG) is a pharmacologically active alkaloid derived from the leaves of Mitragyna speciosa Korth (Kratom). This plant has sparked significant interest as a potential alternative treatment for managing opioid dependence and withdrawal due to its opioid-like pharmacological effects. However, whether MG exposure would trigger opioid-seeking behaviour following abstinence has not been investigated
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Development of a nicotine aerosol self-administration model in rats and the effects of e-liquid flavors Behav. Pharmacol. (IF 1.6) Pub Date : 2023-04-01 Julie A. Marusich, Matthew I. Palmatier
Electronic nicotine delivery system (ENDS) use is maintained by the positive reinforcement associated with preferred flavors. These flavors become conditioned reinforcers through pairings with primary reinforcers. This study sought to extend prior research with intravenous nicotine self-administration and develop a more ecologically valid preclinical model of aerosol self-administration in rats that
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Maternal treatment with aripiprazole prevents the development of a valproic acid-induced autism-like phenotype in juvenile male mice Behav. Pharmacol. (IF 1.6) Pub Date : 2023-04-01 Emerson de Oliveira Ferreira, Jéssica Maria Pessoa Gomes, Kelly Rose Tavares Neves, Francisco Arnaldo Viana Lima, Glauce Socorro de Barros Viana, Geanne Matos de Andrade
Autism spectrum disorder (ASD) describes a heterogeneous group of neurodevelopmental conditions characterized by deficits in social communication and repetitive behaviors. Aripiprazole (APZ) is an atypical antipsychotic that can safeguard mice against autism-like behavior induced by valproic acid (VPA). In the present study, we examined the effects of maternal treatment with APZ (10 mg/kg) in juvenile
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Effects of methylphenidate on impulsive choice and delay aversion in Lewis rats Behav. Pharmacol. (IF 1.6) Pub Date : 2023-04-01 Kelsey Panfil, Robert Small, Kimberly Kirkpatrick
Attention-deficit/hyperactivity disorder (ADHD), a common behavioral disorder in children and young adults, is characterized by symptoms of impulsivity, inattention, and hyperactivity. The purpose of this study was to evaluate the Lewis rat strain as a model of ADHD by testing their impulsive choices. Lewis rats were compared to their source strain, the Wistar rat, on an impulsive choice task. Rats
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Histamine and its H1 receptors in the ventral pallidum mediate formalin-induced pain-related behaviors through this region and spinal cord opioid receptors Behav. Pharmacol. (IF 1.6) Pub Date : 2023-03-06 Morteza Asgharieh-Ahari, Esmaeal Tamaddonfard, Amir Erfanparast, Farhad Soltanalinejad-Taghiabad
Many structures of the central nervous system recruit different neurotransmitters in pain processing. This study focused on the contribution of histamine and its H1 receptors in the ventral pallidum (VP) in mediating pain-triggered behaviors. Intra-VP microinjection of histamine and 2-pyridylethylamine (2-PEA, a histamine H1 receptor agonist) at the same doses of 0.5 and 1 µg/200 nl reduced both the
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Lack of sex and estrous stage effects on compulsive behavior assessed using a schedule-induced polydipsia procedure in rats Behav. Pharmacol. (IF 1.6) Pub Date : 2023-03-06 Min Park-Oates, Adam J. Prus
Preclinical behavior models used for screening pharmacological treatments for mental disorders have generally used only male research subjects, and for studies that have included female subjects, few have utilized sex as a study variable. In fact, many mental disorders vary by prevalence and symptomatology between sexes, creating a need to evaluate established subject models for sex differences. Compulsive
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Synergistic effects of combined therapy with cerebrolysin and enriched environment on anxiety-like behavior and spatial cognitive deficits in posttraumatic stress disorder-like mouse model Behav. Pharmacol. (IF 1.6) Pub Date : 2023-02-10 Leila Hosseini, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Hanieh Salehi-Pourmehr, Amir Pasokh, Mojtaba Ziaee, Siamak Sandoghchian Shotorbani, Mir-Jamal Hosseini, Javad Mahmoudi
Posttraumatic stress disorder (PTSD) is a serious neuropsychiatric disorder that occurs after exposure to stressful, fearful, or troubling events. Cerebrolysin (CBL), consists of low molecular weights neurotrophic factors and amino acids obtained from purified porcine brain proteins. This study aimed to evaluate the possible therapeutic effects of enriched environment (EE) and CBL alone or combined
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5-(4-Hydroxy-3-dimethoxybenzylidene)-thiazolidinone improves motor functions and exerts antioxidant potential in hemiparkinsonian rats Behav. Pharmacol. (IF 1.6) Pub Date : 2023-02-01 Zhili Ren, Hui Ding, Ming Zhou, Nan Yang, Yanyong Liu, Piu Chan
Our previous study demonstrated that 5-(4-hydroxy-3-dimethoxybenzylidene)-thiazolidinone (RD-1), one of rhodamine derivatives, significantly improves motor function in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model and could minimize mitochondrial impairment, which is a potential therapeutic target to slow down the dopaminergic neurodegeneration in Parkinson’s disease. To further evaluate
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Burrowing as an index of inflammatory pain in male vs. female rats Behav. Pharmacol. (IF 1.6) Pub Date : 2023-02-01 Rebecca M. Craft
The study objective was to determine whether burrowing behavior is useful as a functional index of pain in both male and female rats, and whether a ‘no-training’ protocol can be used to increase testing efficiency. Adult Sprague-Dawley rats were injected in one or both hindpaws with oil vehicle or complete Freund’s adjuvant (CFA); starting the next day, the amount of gravel each rat burrowed out of
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Co-administration of bromocriptine and corticosterone produces short- and long-lasting reduction in intake of high-fat food in male rats Behav. Pharmacol. (IF 1.6) Pub Date : 2023-02-01 Víctor H. Castillo-Campohermoso, Luz M. Molina-Martínez, Eliana Barrios de Tomasi, Jorge Juárez
Dopaminergic and glucocorticoid activity has been associated with reduced food consumption; however, their possible synergic action has not yet been studied. With the aim of examining the effect of the co-administration of the dopamine receptor D2 agonist bromocriptine and corticosterone on palatable food intake, male Wistar rats were administered either bromocriptine (1 mg/kg), corticosterone (2 mg/kg)
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Varenicline serves as the training stimulus in the drug-discriminated goal-tracking task with rats: initial evaluation of potential neuropharmacological processes Behav. Pharmacol. (IF 1.6) Pub Date : 2023-02-01 Brady M. Thompson, Matthew E. Tracy, Y. Wendy Huynh, Linda P. Dwoskin, Scott T. Barrett, Rick A. Bevins
Varenicline (Chantix) is an FDA-approved smoking cessation aid that is pharmacologically similar to nicotine, the primary addictive component found within tobacco. In support of this similarity, previous drug discrimination research in rats has reported that the internal or interoceptive stimulus effects of nicotine and varenicline share stimulus elements. Those shared elements appear to be mediated
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Involvement of the NO/cGMP/KATP pathway in the antinociceptive effect of rosemary (Rosmarinus officinalis) essential oil in mice Behav. Pharmacol. (IF 1.6) Pub Date : 2023-02-01 Valiollah Hajhashemi, Majid Salimian, Omid Hajihashemi
Rosemary essential oil (REO) has been used for several medical purposes. Previous studies have shown the antinociceptive effect of the oil. This study aimed to investigate the role of some well-known receptors in the antinociceptive effect of REO. Male Swiss mice (25–30 g) were used. To assess the antinociceptive activity, the formalin test was used. At first, the antinociceptive effect of three doses
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Methamphetamine-induced locomotor sensitization in mice is not associated with deficits in a range of cognitive, affective and social behaviours: interaction with brain-derived neurotrophic factor Val66Met genotype Behav. Pharmacol. (IF 1.6) Pub Date : 2023-02-01 Michelle Corrone, Ruvee Ratnayake, Nicole de Oliveira, Emily J Jaehne, Maarten van den Buuse
Chronic methamphetamine (Meth) abuse may induce psychosis similar to that observed in schizophrenia. Brain-derived neurotrophic factor (BDNF) has been implicated in the development of psychosis. We have previously shown long-term protein expression changes in mice treated chronically with Meth depending on BDNF Val66Met genotype. The aim of this study was to investigate if these protein expression
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Involvement of dopaminergic system in the dentate gyrus of the hippocampus in modulating the orofacial pain-related behaviors in the rats. Behav. Pharmacol. (IF 1.6) Pub Date : 2023-01-04 Amir Haghparast, Mitra Yousefpour, Mina Rashvand, Laya Ghahari, Bita Rohani, Abbas Haghparast
Chemical stimulation of the lateral hypothalamus (LH) induces analgesia by forming neural circuitries with multiple brain regions. The involvement of hippocampal dopaminergic receptors in the LH stimulation-induced antinociception in specific pain models in animals has been documented. However, because the neural circuitries involved in the mediation of orofacial pain are not the same as those that
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Fenofibrate promotes neuroprotection in a model of rotenone-induced Parkinson’s disease Behav. Pharmacol. (IF 1.6) Pub Date : 2022-12-01 Janaína K. Barbiero, Daniele C. Ramos, Suelen Boschen, Taysa Bassani, Cláudio Da Cunha, Maria A. B. F. Vital
Parkinson’s disease is a neurodegenerative disease, the etiology of which remains unknown, but some likely causes include oxidative stress, mitochondrial dysfunction and neuroinflammation. Peroxisome-proliferator-activated receptor (PPAR) agonists have been studied in animal models of Parkinson’s disease and have shown neuroprotective effects. In this study, we aimed to (1) confirm the neuroprotective
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Dual effects of anandamide in the antiepileptic activity of diazepam in pentylenetetrazole-induced seizures in mice Behav. Pharmacol. (IF 1.6) Pub Date : 2022-12-01 Shyamshree S.S. Manna
The prototype endocannabinoid, anandamide activates both CB1 and transient receptor potential vanilloid type 1 channels (TRPV1) receptor at different concentrations. At high concentrations, anandamide-mediated TRPV1 effects are opposite to its effects at low concentrations via CB1 receptor. Thus, synaptic concentrations of anandamide govern the neuronal activity and consequently might affect the response
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Long-term follow-up of intracerebroventricular injection of streptozotocin-inducing pain sensitization Behav. Pharmacol. (IF 1.6) Pub Date : 2022-12-01 Farzaneh Rostami, Zohreh Abbasi, Masoud Fereidoni
Age is known to be the major risk factor for both pain sensation and sporadic Alzheimer’s disease (sAD). Pain management in AD is a critical health condition. However, assessing pain in sAD patients is challenging. The intracerebroventricularly injected streptozotocin (icv-STZ) rat model of sAD has been brought to the fore as a hopefully suitable model that could mimic some features of sAD. However
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Aldehyde dehydrogenase 2–associated changes in pharmacokinetics, locomotor function and peripheral glutamic acid and gamma-aminobutyric acid levels during acute alcohol intoxication in male mice Behav. Pharmacol. (IF 1.6) Pub Date : 2022-12-01 Songfan Li, Yuzi Zheng, Li Xiao, Shengnan Lan, Jin Xiang, Linchuan Liao, Yao Lin, Yi Ye
The insufficiency of human aldehyde dehydrogenase 2 (ALDH2) has been consistently associated with high blood acetaldehyde levels and impaired locomotor function during acute alcohol intoxication. The ALDH2-associated change in peripheral glutamic acid (Glu) and gamma-aminobutyric acid (GABA) levels and its correlation with pharmacokinetics and psychomotor function remain unclear. In this study, ALDH2*2
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The effects of citalopram, SB-334867 and orexin-1, alone or in various combinations, on the anxiogenic-like effects of REM sleep deprivation in male mice Behav. Pharmacol. (IF 1.6) Pub Date : 2022-12-01 Naghmeh Saadati, Maryam Bananej, Fatemeh Khakpai, Mohammad-Reza Zarrindast, Hengameh Alibeik
Sleep deprivation may induce anxiety. On the other hand, anxiety disorders elicit main changes in the quality of sleep. Moreover, orexin and citalopram play a role in the modulation of insomnia and mood diseases. Thus, we planned preclinical research to evaluate the effect of combinations of orexin agents and citalopram on anxiety behavior in rapid eye movement (REM) sleep-deprived mice. For drug
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Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats Behav. Pharmacol. (IF 1.6) Pub Date : 2022-12-01 Ahmad A. Altarifi, Bassel A. Younis, Khawla Q. Nuseir, Arwa A. Al-Mousa, Ahmad K. Qaoud, Mohammad I. Alsalem, John K. Neubert
Pain is a major problem that burdens the health and economy of societies worldwide. Nonsteroidal anti-inflammatory drugs (NSAIDs) are over-the-counter medications that are widely indicated for mild to moderate pain conditions. Clinically, the selection of a medication among this class is mainly based according to both patient’s and doctor’s previous experiences. Herein, we studied differences in therapeutic
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Prenatal exposure to fluoxetine modulates emotionality and aversive memory in male and female rat offspring Behav. Pharmacol. (IF 1.6) Pub Date : 2022-12-01 Sarah Sophia G. Linhares, Ywlliane da Silva R. Meurer, Antônio Carlos Queiroz de Aquino, Diego de Aquino Câmara, Luiz Eduardo M. Brandão, Felipe Porto Fiuza, Ramón Hypolito Lima, Rovena Clara J. G. Engelberth, Jeferson Souza Cavalcante
During pregnancy, women are prone to depression, for which selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are usually the first-line treatment. However, fluoxetine can cross the placental barrier and affect fetuses, causing changes in serotonin levels early in life. Long-term effects in the brain circuits that control cognitive and emotional behavior are related to early fluoxetine
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GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice Behav. Pharmacol. (IF 1.6) Pub Date : 2022-10-01 Leela Afrose, Max V. McDermott, Ashif I. Bhuiyan, Sanjai K. Pathak, Erin N. Bobeck
A newly deorphanized G protein-coupled receptor, GPR171, is found to be highly expressed within the periaqueductal gray, a pain-modulating region in the brain. Our recent research has shown that a GPR171 agonist increases morphine antinociception in male mice and opioid signaling in vitro. The objective of this study was to evaluate the effects of combination treatment in females as well as whether
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The effects of curcumin in learning and memory impairment associated with hypothyroidism in juvenile rats: the role of nitric oxide, oxidative stress, and brain-derived neurotrophic factor Behav. Pharmacol. (IF 1.6) Pub Date : 2022-10-01 Somaieh Ahmadabady, Mahmoud Hosseini, Mohammad Naser Shafei, Narges Marefati, Hossein Salmani, Sabiheh Amirahmadi, Sakineh Sadat Mortazavi Sani, Farimah Beheshti
The effect of curcumin (Cur) on cognitive impairment and the possible role of brain tissue oxidative stress, nitric oxide (NO) levels, and brain-derived neurotrophic factor (BDNF) were investigated in juvenile hypothyroid rats. The juvenile rats (21 days old) were allocated into the following groups: (1) control; (2) hypothyroid (0.05% propylthiouracil (PTU) in drinking water); (3–5) hypothyroid-Cur
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Effort-based decision making in response to high-dose androgens: role of dopamine receptors. Behav. Pharmacol. (IF 1.6) Pub Date : 2022-09-14 Alexandra Donovan, Ruth I Wood
Anabolic-androgenic steroids (AAS) are performance-enhancing drugs used by both world-class and rank-and-file athletes. AAS abuse has been linked with risky decision-making, ranging from drunk driving to abusing multiple drugs. Our lab uses operant behavior in rats to test the effects of AAS (testosterone) on decision making. In our previous study, testosterone caused rats to work harder for food reward
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Involvement of GABAA receptors of lateral habenula in the acquisition and expression phases of morphine-induced place preference in male rats. Behav. Pharmacol. (IF 1.6) Pub Date : 2022-09-14 Elahe Amohashemi, Parham Reisi, Hojjatallah Alaei
The lateral habenula (LHb) is a critical brain structure involved in the aversive response to drug abuse. It has been determined that the gamma-aminobutyric acid (GABA)-ergic system plays the main role in morphine dependency. The role of GABA type A receptors (GABAARs) in LHb on morphine-induced conditioned place preference (CPP) remains unknown. In this study, the effect of bilateral intra-LHb microinjection