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Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms Antibiotics (IF 4.8) Pub Date : 2024-03-18 Farkhod Eshboev, Nilufar Mamadalieva, Pavel A. Nazarov, Hidayat Hussain, Vladimir Katanaev, Dilfuza Egamberdieva, Shakhnoz Azimova
Infectious diseases are a significant challenge to global healthcare, especially in the face of increasing antibiotic resistance. This urgent issue requires the continuous exploration and development of new antimicrobial drugs. In this regard, the secondary metabolites derived from endophytic microorganisms stand out as promising sources for finding antimicrobials. Endophytic microorganisms, residing
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When to Stop Antibiotics in the Critically Ill? Antibiotics (IF 4.8) Pub Date : 2024-03-18 Nathan D. Nielsen, James T. Dean, Elizabeth A. Shald, Andrew Conway Morris, Pedro Povoa, Jeroen Schouten, Nicholas Parchim
Over the past century, antibiotic usage has skyrocketed in the treatment of critically ill patients. There have been increasing calls to establish guidelines for appropriate treatment and durations of antibiosis. Antibiotic treatment, even when appropriately tailored to the patient and infection, is not without cost. Short term risks—hepatic/renal dysfunction, intermediate effects—concomitant superinfections
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Strategies for Preventing and Treating Oral Mucosal Infections Associated with Removable Dentures: A Scoping Review Antibiotics (IF 4.8) Pub Date : 2024-03-18 Adriana Barbosa Ribeiro, Pillar Gonçalves Pizziolo, Lorena Mosconi Clemente, Helena Cristina Aguiar, Beatriz de Camargo Poker, Arthur Augusto Martins e Silva, Laís Ranieri Makrakis, Marco Aurelio Fifolato, Giulia Cristina Souza, Viviane de Cássia Oliveira, Evandro Watanabe, Cláudia Helena Lovato da Silva
Oral infections occur due to contact between biofilm rich in Candida albicans formed on the inner surface of complete dentures and the mucosa. This study investigated historical advances in the prevention and treatment of oral mucosal infection and identified gaps in the literature. Bibliographic research was conducted, looking at PubMed, Embase, Web of Science, and Scopus, where 935 articles were
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Biofilm Development by Mycobacterium avium Complex Clinical Isolates: Effect of Clarithromycin in Ultrastructure Antibiotics (IF 4.8) Pub Date : 2024-03-16 Arij Akir, Abrar Senhaji-Kacha, Maria Carmen Muñoz-Egea, Jaime Esteban, John Jairo Aguilera-Correa
Background: The Mycobacterium avium complex includes the commonest non-tuberculous mycobacteria associated with human infections. These infections have been associated with the production of biofilms in many cases, but there are only a few studies about biofilms produced by the species included in this group. Methods: Three collection strains (M. avium ATCC25291, M. intracellulare ATCC13950, and M
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Generation and Characterization of Stable Small Colony Variants of USA300 Staphylococcus aureus in RAW 264.7 Murine Macrophages Antibiotics (IF 4.8) Pub Date : 2024-03-16 Dalida Bivona, Carmelo Bonomo, Lorenzo Colombini, Paolo G. Bonacci, Grete F. Privitera, Giuseppe Caruso, Filippo Caraci, Francesco Santoro, Nicolò Musso, Dafne Bongiorno, Francesco Iannelli, Stefania Stefani
Intracellular survival and immune evasion are typical features of staphylococcal infections. USA300 is a major clone of methicillin-resistant S. aureus (MRSA), a community- and hospital-acquired pathogen capable of disseminating throughout the body and evading the immune system. Carnosine is an endogenous dipeptide characterized by antioxidant and anti-inflammatory properties acting on the peripheral
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Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution Antibiotics (IF 4.8) Pub Date : 2024-03-17 Faith D. Huynh, Giovanni Damiani, Christopher G. Bunick
Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory dermatological condition characterized by painful and recurrent nodules and purulent abscesses. HS can have a devastating impact on the quality of life of patients. This condition is commonly localized to the axilla, groin, perineal, and inframammary regions, and can develop fistulas and sinus tracts over time. Its pathogenesis
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A Single Dose of Piperacillin Plus Tazobactam Gel as an Adjunct to Professional Mechanical Plaque Removal (PMPR) in Patients with Peri-Implant Mucositis: A 6-Month Double-Blind Randomized Clinical Trial Antibiotics (IF 4.8) Pub Date : 2024-03-17 Ioana Ilyes, Marius Boariu, Darian Rusu, Vincenzo Iorio-Siciliano, Octavia Vela, Simina Boia, Georgios Kardaras, Petra Șurlin, Horia Calniceanu, Holger Jentsch, Alexandru Lodin, Stefan-Ioan Stratul
Objectives: This randomized, placebo-controlled, double-masked clinical trial aimed to evaluate the clinical and microbiological efficacy of professional mechanical plaque removal (PMPR) with or without adjunctive application of piperacillin plus tazobactam gel in the treatment of peri-implant mucositis (PiM) for up to 6 months. Materials and Methods: The study included 31 patients with peri-implant
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Scientific Rationale and Clinical Basis for Clindamycin Use in the Treatment of Dermatologic Disease Antibiotics (IF 4.8) Pub Date : 2024-03-17 Maria K. Armillei, Ivan B. Lomakin, James Q. Del Rosso, Ayman Grada, Christopher G. Bunick
Clindamycin is a highly effective antibiotic of the lincosamide class. It has been widely used for decades to treat a range of skin and soft tissue infections in dermatology and medicine. Clindamycin is commonly prescribed for acne vulgaris, with current practice standards utilizing fixed-combination topicals containing clindamycin that prevent Cutibacterium acnes growth and reduce inflammation associated
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Intrapulmonary and Systemic Pharmacokinetics of Colistin Following Nebulization of Low-Dose Colistimethate Sodium in Patients with Ventilator-Associated Pneumonia Caused by Carbapenem-Resistant Acinetobacter baumannii Antibiotics (IF 4.8) Pub Date : 2024-03-14 Dong-Hwan Lee, Shin-Young Kim, Yong-Kyun Kim, So-Young Jung, Ji-Hoon Jang, Hang-Jea Jang, Jae-Ha Lee
Colistimethate sodium (CMS) nebulization is associated with reduced systemic toxicity compared to intravenous injection, with potentially enhanced clinical efficacy. This study aimed to assess the pharmacokinetic (PK) properties of colistin during low-dose CMS nebulization in patients with ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii. A nonlinear mixed-effects
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Role of β-Lactamase Inhibitors as Potentiators in Antimicrobial Chemotherapy Targeting Gram-Negative Bacteria Antibiotics (IF 4.8) Pub Date : 2024-03-15 Song Zhang, Xinyu Liao, Tian Ding, Juhee Ahn
Since the discovery of penicillin, β-lactam antibiotics have commonly been used to treat bacterial infections. Unfortunately, at the same time, pathogens can develop resistance to β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and carbapenems by producing β-lactamases. Therefore, a combination of β-lactam antibiotics with β-lactamase inhibitors has been a promising approach
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Current Therapeutic Approaches for Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Infections Antibiotics (IF 4.8) Pub Date : 2024-03-15 Petros Rafailidis, Periklis Panagopoulos, Christos Koutserimpas, George Samonis
The treatment of Acinetobacter baumannii infections remains a challenge for physicians worldwide in the 21st century. The bacterium possesses a multitude of mechanisms to escape the human immune system. The consequences of A. baumannii infections on morbidity and mortality, as well on financial resources, remain dire. Furthermore, A. baumannii superinfections have also occurred during the COVID-19
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The Clinical Efficacy of Adding Ceftazidime/Avibactam to Standard Therapy in Treating Infections Caused by Carbapenem-Resistant Klebsiella pneumonia with blaOXA-48-like Genes Antibiotics (IF 4.8) Pub Date : 2024-03-16 Al Maamon R. Abu Jaber, Bilgen Basgut, Ali Abdullah Hawan, Ali Amer Al Shehri, Sultan Ahmad AlKahtani, Nehad J. Ahmed, Abdikarim Abdi
Ceftazidime/avibactam (CAZ-AVI) is FDA-approved for managing infections caused by resistant gram-negative bacilli, particularly infections via carbapenem-resistant Enterobacterales pathogens. The clinical data are still limited, particularly those in Saudi Arabia. The present study is a retrospective cohort study that was carried out at the Armed Forces Hospital in the southern region of Saudi Arabia
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Identification and Clinical Characteristics of Community-Acquired Acinetobacter baumannii in Patients Hospitalized for Moderate or Severe COVID-19 in Peru Antibiotics (IF 4.8) Pub Date : 2024-03-16 Wilmer Silva-Caso, Giancarlo Pérez-Lazo, Miguel Angel Aguilar-Luis, Adriana Morales-Moreno, José Ballena-López, Fernando Soto-Febres, Johanna Martins-Luna, Luis J. Del Valle, Sungmin Kym, Deysi Aguilar-Luis, Dayana Denegri-Hinostroza, Juana del Valle-Mendoza
Acinetobacter baumannii has been described as a cause of serious community-acquired infections in tropical countries. Currently, its implications when simultaneously identified with other pathogens are not yet adequately understood. A descriptive study was conducted on hospitalized patients with a diagnosis of moderate/severe SARS-CoV-2-induced pneumonia confirmed via real-time RT-PCR. Patients aged
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Chestnut Honey Is Effective against Mixed Biofilms at Different Stages of Maturity Antibiotics (IF 4.8) Pub Date : 2024-03-13 Regina Koloh, Viktória L. Balázs, Lilla Nagy-Radványi, Béla Kocsis, Erika Beáta Kerekes, Marianna Kocsis, Ágnes Farkas
The irresponsible overuse of antibiotics has increased the occurrence of resistant bacterial strains, which represents one of the biggest patient safety risks today. Due to antibiotic resistance and biofilm formation in bacteria, it is becoming increasingly difficult to suppress the bacterial strains responsible for various chronic infections. Honey was proven to inhibit bacterial growth and biofilm
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Pan-Genome Plasticity and Virulence Factors: A Natural Treasure Trove for Acinetobacter baumannii Antibiotics (IF 4.8) Pub Date : 2024-03-14 Theodoros Karampatakis, Katerina Tsergouli, Payam Behzadi
Acinetobacter baumannii is a Gram-negative pathogen responsible for a variety of community- and hospital-acquired infections. It is recognized as a life-threatening pathogen among hospitalized individuals and, in particular, immunocompromised patients in many countries. A. baumannii, as a member of the ESKAPE group, encompasses high genomic plasticity and simultaneously is predisposed to receive and
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Detection of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacteriaceae from Diseased Broiler Chickens in Lusaka District, Zambia Antibiotics (IF 4.8) Pub Date : 2024-03-15 Chikwanda Chileshe, Misheck Shawa, Nelson Phiri, Joseph Ndebe, Cynthia Sipho Khumalo, Chie Nakajima, Kajihara Masahiro, Hideaki Higashi, Hirofumi Sawa, Yasuhiko Suzuki, Walter Muleya, Bernard Mudenda Hang’ombe
Poultry products in Zambia form an integral part of the human diet in many households, as they are cheap and easy to produce. The burden of poultry diseases has, however, remained a major challenge. Growing consumer demand for poultry products in Zambia has resulted in non-prudent antimicrobial use on farms, intending to prevent and treat poultry diseases for growth optimisation and maximising profits
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Post-COVID-19 Pandemic Rebound of Macrolide-Resistant Mycoplasma pneumoniae Infection: A Descriptive Study Antibiotics (IF 4.8) Pub Date : 2024-03-15 Fan-Fan Xing, Kelvin Hei-Yeung Chiu, Chao-Wen Deng, Hai-Yan Ye, Lin-Lin Sun, Yong-Xian Su, Hui-Jun Cai, Simon Kam-Fai Lo, Lei Rong, Jian-Liang Chen, Vincent Chi-Chung Cheng, David Christopher Lung, Siddharth Sridhar, Jasper Fuk-Woo Chan, Ivan Fan-Ngai Hung, Kwok-Yung Yuen
The rebound characteristics of respiratory infections after lifting pandemic control measures were uncertain. From January to November 2023, patients presenting at a teaching hospital were tested for common respiratory viruses and Mycoplasma pneumoniae using a combination of antigen, nucleic acid amplification, and targeted next-generation sequencing (tNGS) tests. The number and rate of positive tests
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Evaluation of Hospital Antimicrobial Stewardship Programs: Implementation, Process, Impact, and Outcomes, Review of Systematic Reviews Antibiotics (IF 4.8) Pub Date : 2024-03-12 Hamad Abdel Hadi, Faiha Eltayeb, Sara Al Balushi, Joanne Daghfal, Faraz Ahmed, Ceu Mateus
Antimicrobial Stewardship Programs (ASP) were introduced in healthcare as a public health priority to promote appropriate prescribing of antimicrobials, to reduce adverse events related to antimicrobials, as well as to control the escalating challenges of antimicrobial resistance. To deliver aimed outcome objectives, ASPs involve multiple connected implementation process measures. A systematic review
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Daptomycin Use for Persistent Coagulase-Negative Staphylococcal Bacteremia in a Neonatal Intensive Care Unit Antibiotics (IF 4.8) Pub Date : 2024-03-12 Eleni Papachatzi, Despoina Gkentzi, Sotiris Tzifas, Theodore Dassios, Gabriel Dimitriou
During the last two decades, the incidence of late-onset sepsis (LOS) has increased due to improved survival of premature neonates. Persistent bacteremia (PB) in LOS is defined as more than two positive blood cultures obtained on different calendar days during the same infectious episode. Although rare, PB should be treated aggressively to prevent adverse outcomes. Daptomycin, a lipopeptide antibiotic
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Microbiological Quality and Safety of Fresh Rabbit Meat with Special Reference to Methicillin-Resistant S. aureus (MRSA) and ESBL-Producing E. coli Antibiotics (IF 4.8) Pub Date : 2024-03-13 Jessica da Silva Guedes, David Velilla-Rodriguez, Elena González-Fandos
The purpose of this investigation was to evaluate the microbial quality and safety of rabbit meat. A total of 49 rabbit meat samples were taken at the retail level. The mesophiles, staphylococci, Enterobacterales, and Pseudomonas spp. counts were 4.94 ± 1.08, 2.59 ± 0.70, 2.82 ± 0.67, and 3.23 ± 0.76 log CFU/g, respectively. Campylobacter spp. were not detected in any sample. Listeria monocytogenes
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Antimicrobial Properties of Colostrum and Milk Antibiotics (IF 4.8) Pub Date : 2024-03-11 Furkan Eker, Emir Akdaşçi, Hatice Duman, Yalçın Mert Yalçıntaş, Ahmet Alperen Canbolat, Arda Erkan Kalkan, Sercan Karav, Dunja Šamec
The growing number of antibiotic resistance genes is putting a strain on the ecosystem and harming human health. In addition, consumers have developed a cautious attitude towards chemical preservatives. Colostrum and milk are excellent sources of antibacterial components that help to strengthen the immunity of the offspring and accelerate the maturation of the immune system. It is possible to study
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Navigating the Chemical Space of ENR Inhibitors: A Comprehensive Analysis Antibiotics (IF 4.8) Pub Date : 2024-03-11 Vid Kuralt, Rok Frlan
Antimicrobial resistance is a global health threat that requires innovative strategies against drug-resistant bacteria. Our study focuses on enoyl-acyl carrier protein reductases (ENRs), in particular FabI, FabK, FabV, and InhA, as potential antimicrobial agents. Despite their promising potential, the lack of clinical approvals for inhibitors such as triclosan and isoniazid underscores the challenges
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An Overview of Antibiotic Therapy for Early- and Late-Onset Neonatal Sepsis: Current Strategies and Future Prospects Antibiotics (IF 4.8) Pub Date : 2024-03-10 Giovanni Boscarino, Rossana Romano, Carlotta Iotti, Francesca Tegoni, Serafina Perrone, Susanna Esposito
Neonatal sepsis is a clinical syndrome mainly associated with a bacterial infection leading to severe clinical manifestations that could be associated with fatal sequalae. According to the time of onset, neonatal sepsis is categorized as early- (EOS) or late-onset sepsis (LOS). Despite blood culture being the gold standard for diagnosis, it has several limitations, and early diagnosis is not immediate
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National Level Cross-Sectional Study on Antibiotic Use in Children during the Pre- and Early COVID-19 Eras Antibiotics (IF 4.8) Pub Date : 2024-03-09 Ji Young Park, Hyun Mi Kang
This study aimed to investigate national data for a quantitative evaluation of antibiotic usage in Korean children during the pre- and early COVID-19 period. This was a cross-sectional study from 2016 to 2021 of children <18 years, grouped by age (0, 1, 2–4, 5–11, and 12–17 years) and city/province. Systemic antibiotic prescriptions, days of administration, and population by age and region were collected
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The Synthetic Peptide LyeTx I mn∆K, Derived from Lycosa erythrognatha Spider Toxin, Is Active against Methicillin-Resistant Staphylococcus aureus (MRSA) In Vitro and In Vivo Antibiotics (IF 4.8) Pub Date : 2024-03-08 Ana Paula Gonçalves Coelho Vieira, Amanda Neves de Souza, William Gustavo Lima, Julio Cesar Moreira Brito, Daniela Carolina Simião, Lucas Vinícius Ribeiro Gonçalves, Lídia Pereira Barbosa Cordeiro, Denise de Oliveira Scoaris, Simone Odília Antunes Fernandes, Jarbas Magalhães Resende, Burkhard Bechinger, Rodrigo Moreira Verly, Maria Elena de Lima
The urgent global health challenge posed by methicillin-resistant Staphylococcus aureus (MRSA) infections demands effective solutions. Antimicrobial peptides (AMPs) represent promising tools of research of new antibacterial agents and LyeTx I mn∆K, a short synthetic peptide based on the Lycosa erythrognatha spider venom, is a good representative. This study focused on analyzing the antimicrobial activities
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Assessing the Microbial Quality of Shrimp (Xiphonaeus kroyeri) and Mussels (Perna perna) Illegally Sold in the Vitória Region, Brazil, and Investigating the Antimicrobial Resistance of Escherichia coli Isolates Antibiotics (IF 4.8) Pub Date : 2024-03-06 Daniella Tosta Link, Gustavo Guimarães Fernandes Viana, Lívia Pasolini Siqueira, Carolina Magri Ferraz, Romário Alves Rodrigues, Luis Antonio Mathias, Marita Vedovelli Cardozo, Gabriel Augusto Marques Rossi
The consumption of seafood is crucial for food security, but poor hygiene along the food production chain can result in low microbiological quality, posing significant risks for public health and seafood quality. Thus, this study aimed to assess the microbiological quality and antimicrobial sensitivity of E. coli from 69 samples of illegally marketed shrimp and mussels in the Vitória Region, Brazil
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The Application of Knowledge-Based Clinical Decision Support Systems to Detect Antibiotic Allergy Antibiotics (IF 4.8) Pub Date : 2024-03-07 Nayoung Han, Ock Hee Oh, John Oh, Yoomi Kim, Younghee Lee, Won Chul Cha, Yun Mi Yu
Prevention of drug allergies is important for patient safety. The objective of this study was to evaluate the outcomes of antibiotic allergy-checking clinical decision support system (CDSS), K-CDSTM. A retrospective chart review study was performed in 29 hospitals and antibiotic allergy alerts data were collected from May to August 2022. A total of 15,535 allergy alert cases from 1586 patients were
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Whole Genome Sequencing Reveals Antimicrobial Resistance and Virulence Genes of Both Pathogenic and Non-Pathogenic B. cereus Group Isolates from Foodstuffs in Thailand Antibiotics (IF 4.8) Pub Date : 2024-03-07 Phornphan Sornchuer, Kritsakorn Saninjuk, Sumet Amonyingcharoen, Jittiporn Ruangtong, Nattaya Thongsepee, Pongsakorn Martviset, Pathanin Chantree, Kant Sangpairoj
Members of the Bacillus cereus group are spore-forming Gram-positive bacilli that are commonly associated with diarrheal or emetic food poisoning. They are widespread in nature and frequently present in both raw and processed food products. Here, we genetically characterized 24 B. cereus group isolates from foodstuffs. Whole-genome sequencing (WGS) revealed that most of the isolates were closely related
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The Use of CHROMID® Colistin R for the Detection of Colistin-Resistant Gram-Negative Bacteria in Positive Blood Cultures Antibiotics (IF 4.8) Pub Date : 2024-03-07 Emma C. L. Marrs, Olivia Milburn, Gary J. Eltringham, Danielle J. C. Fenwick, Sylvain Orenga, Gulsen Hazırolan, Pinar Zarakolu, John D. Perry
The aim of this study was to assess the utility of CHROMID® Colistin R for direct detection of colistin-resistant Gram-negative bacteria from positive blood cultures. A total of 390 blood cultures from hospitalised patients containing Gram-negative bacteria were included in this study. These blood cultures were referred to clinical laboratories in the United Kingdom and Türkiye. A further 16 simulated
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In Vitro Microevolution and Co-Selection Assessment of Amoxicillin and Cefotaxime Impact on Escherichia coli Resistance Development Antibiotics (IF 4.8) Pub Date : 2024-03-07 Ádám Kerek, Bence Török, Levente Laczkó, Zoltán Somogyi, Gábor Kardos, Krisztián Bányai, Eszter Kaszab, Krisztina Bali, Ákos Jerzsele
The global spread of antimicrobial resistance has become a prominent issue in both veterinary and public health in the 21st century. The extensive use of amoxicillin, a beta-lactam antibiotic, and consequent resistance development are particularly alarming in food-producing animals, with a focus on the swine and poultry sectors. Another beta-lactam, cefotaxime, is widely utilized in human medicine
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The Microbiological Profile and Antibiotic Susceptibility of Fracture Related Infections in a Low Resource Setting Differ from High Resource Settings: A Cohort Study from Cameroon Antibiotics (IF 4.8) Pub Date : 2024-03-04 Loïc Fonkoue, Elizabeth K. Tissingh, Michelle Tognia Ngouateu, Kennedy Olivier Muluem, Olivier Ngongang, Pretty Mbouyap, Perrin Ngougni-Pokem, Kuetche Fotsing, Jean Bahebeck, Martin McNally, Olivier Cornu
Fracture-related infection (FRI) is a common and devastating complication of orthopedic trauma in all settings. Data on the microbiological profile and susceptibility of FRI to antibiotics in low-income countries are scarce. Therefore, this study aimed to investigate the microbial patterns and antimicrobial susceptibility of FRI in a sub-Saharan African setting in order to provide guidance for the
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Anti-Microbial Activities of Mussel-Derived Recombinant Proteins against Gram-Negative Bacteria Antibiotics (IF 4.8) Pub Date : 2024-03-05 Dong Yun Kim, You Bin Oh, Je Seon Park, Yu-Hong Min, Min Chul Park
Many anti-microbial peptides (AMPs) and pro-apoptotic peptides are considered as novel anti-microbial agents, distinguished by their different characteristics. Nevertheless, AMPs exhibit certain limitations, including poor stability and potential toxicity, which hinder their suitability for applications in pharmaceutics and medical devices. In this study, we used recombinant mussel adhesive protein
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Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli in a Dairy Herd: Distribution and Antimicrobial Resistance Profiles Antibiotics (IF 4.8) Pub Date : 2024-03-05 Martina Penati, Laura Musa, Laura Filippone Pavesi, Alessandro Guaraglia, Fernando Ulloa, Paolo Moroni, Renata Piccinini, Maria Filippa Addis
This study investigated the presence, distribution, and antimicrobial resistance profiles of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in a dairy herd located in Northern Italy. The feces of clinically healthy calves, their mothers, and the cows treated for mastitis, as well as water, environmental samples, and waste milk were collected and subjected to bacteriological culture
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Experience with PCR Testing for Enteric Bacteria and Viruses of Emergency Department Patients with Acute Gastroenteritis: Are There Implications for the Early Treatment of Clostridioides difficile Infection? Antibiotics (IF 4.8) Pub Date : 2024-03-06 Andreas Iffland, Maria Zechel, Jan-Christoph Lewejohann, Birgit Edel, Stefan Hagel, Michael Hartmann, Bettina Löffler, Jürgen Rödel
Early identification of acute gastroenteritis (AGE) pathogens via PCR may improve the management of patients presenting to the emergency department (ED). In this study, we evaluated the implementation of a testing algorithm for ED patients with AGE using the BD MAX automated PCR system. Data from 133 patients were analyzed. A total of 56 patients (42%) tested positive via PCR for at least one bacterial
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Antibacterial Effect of Eight Essential Oils against Bacteria Implicated in Bovine Mastitis and Characterization of Primary Action Mode of Thymus capitatus Essential Oil Antibiotics (IF 4.8) Pub Date : 2024-03-05 Chedia Aouadhi, Ahlem Jouini, Karima Maaroufi, Abderrazak Maaroufi
During the current investigation, eight essential oils (EOs) were tested for their antimicrobial activity against six species, belonging to the genus of staphylococcus, multi-resistant to antibiotics (S. epidermidis, S. cohni, S. wareneri, S. scuiri, S. chromogenes, S. pasteuri), three methicillin-resistant Staphylococcus aureus strains (MRSA) and two strains of Escherichia coli, producing extended-spectrum
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Bacterial Infections in Intensive Care Units: Epidemiological and Microbiological Aspects Antibiotics (IF 4.8) Pub Date : 2024-03-05 Maddalena Calvo, Stefania Stefani, Giuseppe Migliorisi
Intensive care units constitute a critical setting for the management of infections. The patients’ fragilities and spread of multidrug-resistant microorganisms lead to relevant difficulties in the patients’ care. Recent epidemiological surveys documented the Gram-negative bacteria supremacy among intensive care unit (ICU) infection aetiologies, accounting for numerous multidrug-resistant isolates.
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Impact of Genital Infections and Antibiotic Use on Incidence of Preterm Birth: A Retrospective Observational Study Antibiotics (IF 4.8) Pub Date : 2024-03-05 Daniela Teodora Marti, Felix Bratosin, Ovidiu Rosca, Roxana Folescu, Cosmin Citu, Adrian Ratiu, Zoran Laurentiu Popa
This study investigates the complex interplay among genital infections, antibiotic usage, and preterm birth. This study aims to identify common genital pathogens associated with preterm births, assess the impact of various antibiotic treatments on pregnancy outcomes, and understand antibiotic resistance patterns among these pathogens. This study included 71 pregnant women who experienced preterm birth
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Oral Antibiotics Alone versus Oral Antibiotics Combined with Mechanical Bowel Preparation for Elective Colorectal Surgery: A Propensity Score-Matching Re-Analysis of the iCral 2 and 3 Prospective Cohorts Antibiotics (IF 4.8) Pub Date : 2024-03-03 Marco Catarci, Stefano Guadagni, Francesco Masedu, Massimo Sartelli, Leonardo Antonio Montemurro, Gian Luca Baiocchi, Giovanni Domenico Tebala, Felice Borghi, Pierluigi Marini, Marco Scatizzi, the Italian ColoRectal Anastomotic Leakage (iCral) Study Group
The evidence regarding the role of oral antibiotics alone (oA) or combined with mechanical bowel preparation (MoABP) for elective colorectal surgery remains controversial. A prospective database of 8359 colorectal resections gathered over a 32-month period from 78 Italian surgical units (the iCral 2 and 3 studies), reporting patient-, disease-, and procedure-related variables together with 60-day adverse
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Scolopax rusticola Carrying Enterobacterales Harboring Antibiotic Resistance Genes Antibiotics (IF 4.8) Pub Date : 2024-03-02 Valeria Gargano, Delia Gambino, Adriana Maria Oddo, Mariangela Pizzo, Arianna Sucato, Gaetano Cammilleri, Francesco La Russa, Maria Liliana Di Pasquale, Maria Giovanna Parisi, Giovanni Cassata, Giuseppe Giangrosso
The Eurasian woodcock (Scolopax rusticola) belongs to those bird species that make systematic migratory flights in spring and autumn in search of favorable breeding and wintering areas. These specimens arrive in the Mediterranean Area from northeastern European countries during the autumn season. The purpose of this study was to assess whether woodcocks can carry antibiotic resistance genes (ARGs)
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Predictive Modeling of Phenotypic Antimicrobial Susceptibility of Selected Beta-Lactam Antimicrobials from Beta-Lactamase Resistance Genes Antibiotics (IF 4.8) Pub Date : 2024-02-28 Md. Kaisar Rahman, Ryan B. Williams, Samuel Ajulo, Gizem Levent, Guy H. Loneragan, Babafela Awosile
The outcome of bacterial infection management relies on prompt diagnosis and effective treatment, but conventional antimicrobial susceptibility testing can be slow and labor-intensive. Therefore, this study aims to predict phenotypic antimicrobial susceptibility of selected beta-lactam antimicrobials in the bacteria of the family Enterobacteriaceae from different beta-lactamase resistance genotypes
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Post-Coronavirus Disease 2019 Pandemic Antimicrobial Resistance Antibiotics (IF 4.8) Pub Date : 2024-02-29 Lucia Boccabella, Elena Gialluca Palma, Ludovico Abenavoli, Giuseppe Guido Maria Scarlata, Mariavirginia Boni, Gianluca Ianiro, Pierangelo Santori, Jan F. Tack, Emidio Scarpellini
Background and aim: Antimicrobial resistance (AMR) is a chronic issue of our Westernized society, mainly because of the uncontrolled and improper use of antimicrobials. The coronavirus disease 2019 (COVID-19) pandemic has triggered and expanded AMR diffusion all over the world, and its clinical and therapeutic features have changed. Thus, we aimed to review evidence from the literature on the definition
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Potential Antifungal Effect of Copper Oxide Nanoparticles Combined with Fungicides against Botrytis cinerea and Fusarium oxysporum Antibiotics (IF 4.8) Pub Date : 2024-02-26 Javiera Parada, Gonzalo Tortella, Amedea B. Seabra, Paola Fincheira, Olga Rubilar
Copper oxide nanoparticles (NCuO) have emerged as an alternative to pesticides due to their antifungal effect against various phytopathogens. Combining them with fungicides represents an advantageous strategy for reducing the necessary amount of both agents to inhibit fungal growth, simultaneously reducing their environmental release. This study aimed to evaluate the antifungal activity of NCuO combined
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Assessment and Assay Comparison for Detection of Antimicrobial Residues in Freshwater Aquaculture Fish in Erbil Governorate, Iraq Antibiotics (IF 4.8) Pub Date : 2024-02-28 Dhary Alewy Almashhadany, Abdulwahed Ahmed Hassan, Rzgar Farooq Rashid, Amir Abdulmawjood, Izhar U. H. Khan
The excessive and uncontrolled application of antibiotics in the fish farming industry, coupled with a lack of health monitoring and medication practices, is a driving force behind the escalating development of antimicrobial resistance. The present study assessed and compared qualitative field diffusion (QFD) and disk diffusion (DD) assays for the detection of antimicrobial residues (ARs) in diverse
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Polylactic Glycolic Acid-Mediated Delivery of Plectasin Derivative NZ2114 in Staphylococcus epidermidis Biofilms Antibiotics (IF 4.8) Pub Date : 2024-02-29 Xuanxuan Ma, Na Yang, Ruoyu Mao, Ya Hao, Da Teng, Yinhua Huang, Jianhua Wang
Antimicrobial peptides (AMPs) are antibiotic candidates; however, their instability and protease susceptibility limit clinical applications. In this study, the polylactic acid–glycolic acid (PLGA)–polyvinyl alcohol (PVA) drug delivery system was screened by orthogonal design using the double emulsion–solvent evaporation method. NZ2114 nanoparticles (NZ2114-NPs) displayed favorable physicochemical properties
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Efficacy of Continuous vs. Intermittent Administration of Cefepime in Adult ICU Patients with Gram-Negative Bacilli Bacteremia: A Randomized Double-Blind Clinical Study Antibiotics (IF 4.8) Pub Date : 2024-02-29 Carlos Arturo Álvarez-Moreno, Laura Cristina Nocua-Báez, Guillermo Ortiz, Juan Carlos Torres, Gabriel Montenegro, Williams Cervera, Luis Fernando Zuluaga, Alonso Gómez
Introduction: The objective of this study was to compare the continuous infusion of cefepime with the intermittent infusion in patients with sepsis caused by Gram-negative bacilli (GNB). Methods: Randomized 1:1 multicenter double-blinded placebo-controlled study with allocation concealment; multicenter study in the intensive care units of Colombia. Patients with sepsis, severe sepsis or septic shock
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Chemical Characterization and Biological Properties Assessment of Euphorbia resinifera and Euphorbia officinarum Moroccan Propolis Antibiotics (IF 4.8) Pub Date : 2024-02-29 Oumaima Boutoub, Soukaina El-Guendouz, Isabel Matos, Lahsen El Ghadraoui, Maria Clara Costa, Jorge Dias Carlier, Maria Leonor Faleiro, Ana Cristina Figueiredo, Letícia M. Estevinho, Maria Graça Miguel
Although the plants of the genus Euphorbia are largely exploited by therapists in Morocco, the composition and antibacterial activities of propolis from these plants are still unknown. To address this gap, this study aimed to characterize the pollen type, the volatile compounds, and the phenolic and mineral profiles of three Euphorbia propolis samples collected in Morocco and evaluate their antimicrobial
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Rapid Phenotypic Antibiotic Susceptibility Profiling of Clinical Escherichia coli and Klebsiella pneumoniae Blood Cultures Antibiotics (IF 4.8) Pub Date : 2024-02-29 Idan Hefetz, Rita Bardenstein, Shahar Rotem, Galia Zaide, Gal Bilinsky, Ohad Shifman, Oren Zimhony, Ronit Aloni-Grinstein
Bloodstream infections (BSI) are defined by the presence of viable bacteria or fungi, accompanied by systemic signs of infection. Choosing empirical therapy based solely on patient risk factors and prior antibiotic susceptibility test (AST) may lead to either ineffective treatment or unnecessarily broad-spectrum antibiotic exposure. In general, Clinical & Laboratory Standards Institute guideline-approved
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Antimicrobial Resistance and Sports: The Scope of the Problem, Implications for Athletes’ Health and Avenues for Collaborative Public Health Action Antibiotics (IF 4.8) Pub Date : 2024-02-29 Ognjen Ožegić, Branka Bedenić, Sunčanica Ljubin Sternak, Mario Sviben, Jasminka Talapko, Iva Pažur, Ivana Škrlec, Ivan Segedi, Tomislav Meštrović
Antimicrobial resistance (AMR) poses a global threat, leading to increased mortality and necessitating urgent action—however, its impact on athletes and the world of sports has hitherto been neglected. Sports environments (including athletic and aquatic) exhibit high levels of microbial contamination, potentially contributing to the spread of resistant microorganisms during physical activities. Moreover
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Community Emergence of Cefixime-Resistant Escherichia coli Belonging to ST12 with Chromosomal AmpC Hyperproduction Antibiotics (IF 4.8) Pub Date : 2024-02-27 Gloria Zaragoza, María Pérez-Vázquez, Laura Villar-Gómara, Andrea González-Prieto, Jesús Oteo-Iglesias, Juan-Ignacio Alós
Escherichia coli isolates that are resistant to cefixime and amoxicillin/clavulanic acid, but apparently susceptible to cefuroxime, with no ESBL identified, were initially detected in Madrid from urine samples in 2019. Throughout 2020 and 2021, all cases of community UTI by E. coli from six health areas in Madrid were studied. A representative sample of 23 cases was selected for further studies. The
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Antisense and Functional Nucleic Acids in Rational Drug Development Antibiotics (IF 4.8) Pub Date : 2024-02-27 Robert Penchovsky, Antoniya V. Georgieva, Vanya Dyakova, Martina Traykovska, Nikolet Pavlova
This review is focused on antisense and functional nucleic acid used for completely rational drug design and drug target assessment, aiming to reduce the time and money spent and increase the successful rate of drug development. Nucleic acids have unique properties that play two essential roles in drug development as drug targets and as drugs. Drug targets can be messenger, ribosomal, non-coding RNAs
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A Cyclam Salt as an Antifungal Agent: Interference with Candida spp. and Cryptococcus neoformans Mechanisms of Virulence Antibiotics (IF 4.8) Pub Date : 2024-02-28 Fátima Cerqueira, Rui Medeiros, Inês Lopes, Carla Campos, Maria Pia Ferraz, Fernando Silva, Luís G. Alves, Eugénia Pinto
The importance of fungal infections, particularly those caused by yeasts, is increasing among the medical community. Candida albicans and Cryptococcus neoformans are amongst the high-priority fungal species identified by the World Health Organization (WHO) and are considered in the critical group, while Candida krusei is included in the medium-priority group. The cyclam salt H4[H2(4-CF3PhCH2)2Cyclam]Cl4
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Examining Antimicrobial Resistance in Escherichia coli: A Case Study in Central Virginia’s Environment Antibiotics (IF 4.8) Pub Date : 2024-02-28 Chyer Kim, Allissa Riley, Shobha Sriharan, Theresa Nartea, Eunice Ndegwa, Ramesh Dhakal, Guolu Zheng, Claire Baffaut
While environmental factors may contribute to antimicrobial resistance (AMR) in bacteria, many aspects of environmental antibiotic pollution and resistance remain unknown. Furthermore, the level of AMR in Escherichia coli is considered a reliable indicator of the selection pressure exerted by antimicrobial use in the environment. This study aimed to assess AMR variance in E. coli isolated from diverse
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New Insights into Cutaneous Asepsis: Synergism between Pfaffia and Rosemary Extracts Antibiotics (IF 4.8) Pub Date : 2024-02-28 Diego Garcia Miranda, Florence Carrouel, Tatiane Cristina Alberti Silva, Mariana Cafalchio Rozzatto, Amjad Abu Hasna, Carlos Eduardo Rocha Santos, Flavia Villaça Morais, Luciane Dias de Oliveira, Lucas de Paula Ramos
(1) Background: In hospitals, medical and dental clinics, antiseptics or disinfectants play an essential role in the control of nosocomial infections. This study aimed to evaluate R. officinalis and P. paniculata glycolic extracts regarding: (I) their antimicrobial action on planktonic and biofilm (monotypic and cutaneous biofilm model—S. aureus, S. epidermidis and C. acnes); and (II) their cytotoxicity
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First Report of Colistin-Resistant Escherichia coli Carrying mcr-1 IncI2(delta) and IncX4 Plasmids from Camels (Camelus dromedarius) in the Gulf Region Antibiotics (IF 4.8) Pub Date : 2024-02-28 Akela Ghazawi, Nikolaos Strepis, Febin Anes, Dana Yaaqeib, Amal Ahmed, Aysha AlHosani, Mirah AlShehhi, Ashrat Manzoor, Ihab Habib, Nisar A. Wani, John P. Hays, Mushtaq Khan
Addressing the emergence of antimicrobial resistance (AMR) poses a significant challenge in veterinary and public health. In this study, we focused on determining the presence, phenotypic background, and genetic epidemiology of plasmid-mediated colistin resistance (mcr) in Escherichia coli bacteria isolated from camels farmed in the United Arab Emirates (UAE). Fecal samples were collected from 50 camels
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Hyperbranched Polylysine Exhibits a Collaborative Enhancement of the Antibiotic Capacity to Kill Gram-Negative Pathogens Antibiotics (IF 4.8) Pub Date : 2024-02-26 Yuxin Gong, Qing Peng, Yu Qiao, Dandan Tian, Yuwei Zhang, Xiaoyan Xiong, Mengxin He, Xiaoqing Xu, Bo Shi
In recent years, traditional antibiotic efficacy outcomes have rapidly diminished due to the advent of drug resistance, and the dose limitation value has increased due to the severe side effect of globalized healthcare. Therefore, novel strategies are required to resensitize resistant pathogens to antibiotics existing in the field and prevent the emergence of drug resistance. In this study, cationic
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Decline in ESBL Production and Carbapenem Resistance in Urinary Tract Infections among Key Bacterial Species during the COVID-19 Pandemic Antibiotics (IF 4.8) Pub Date : 2024-02-26 Ibraheem Altamimi, Khalifa Binkhamis, Abdullah Alhumimidi, Ibrahim M. Alabdulkarim, Abdulrahman Almugren, Hadi Alhemsi, Abdulaziz Altamimi, Abeer Almazyed, Seham Elbih, Razan Alghunaim, Abdullah Altamimi
The COVID-19 pandemic has led to significant changes in healthcare practices, including increased antibiotic usage. This study aimed to investigate the impact of the pandemic on the prevalence of extended-spectrum β-lactamase (ESBL) production and carbapenem resistance among key bacterial species causing urinary tract infections (UTIs). Conducted at King Fahad Medical City in Riyadh from January 2018
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Relationship between Target Time above Minimum Inhibitory Concentration Achievement Rate of Meropenem Using Monte Carlo Simulation and In-Hospital Survival in Patients with Pseudomonas aeruginosa Bacteremia Antibiotics (IF 4.8) Pub Date : 2024-02-27 Hajime Nakashima, Motoyasu Miyazaki, Tsuneo Kuwamura, Kazutaka Oda, Yumi Haga, Osamu Imakyure
Pseudomonas aeruginosa bacteremia is associated with a high mortality rate, and meropenem (MEPM) is commonly used to treat it. However, the relationship between the time above the minimum inhibitory concentration (fT>MIC) of MEPM and its therapeutic efficacy in P. aeruginosa bacteremia has not been explored. This study aimed to investigate this relationship by defining the target % fT>MIC of MEPM as
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Unraveling the Complex Interactions: Machine Learning Approaches to Predict Bacterial Survival against ZnO and Lanthanum-Doped ZnO Nanoparticles Antibiotics (IF 4.8) Pub Date : 2024-02-27 Diego E. Navarro-López, Yocanxóchitl Perfecto-Avalos, Araceli Zavala, Marco A. de Luna, Araceli Sanchez-Martinez, Oscar Ceballos-Sanchez, Naveen Tiwari, Edgar R. López-Mena, Gildardo Sanchez-Ante
The rise in antibiotic-resistant bacteria is a global health challenge. Due to their unique properties, metal oxide nanoparticles show promise in addressing this issue. However, optimizing these properties requires a deep understanding of complex interactions. This study incorporated data-driven machine learning to predict bacterial survival against lanthanum-doped ZnO nanoparticles. The effect of
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Control of Escherichia coli in Poultry Using the In Ovo Injection Technique Antibiotics (IF 4.8) Pub Date : 2024-02-22 Gabriel da Silva Oliveira, Concepta McManus, Vinícius Machado dos Santos
Pathogens, such as Escherichia coli (E. coli), have been identified as significant causes of poultry mortality. Poultry can serve as potential sources of E. coli transmission, even when asymptomatic, posing a substantial threat to food safety and human health. The in ovo administration of antimicrobials is crucial for preventing and/or effectively combating acute and chronic infections caused by poultry
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Antimicrobial Resistance in Qatar: Prevalence and Trends before and Amidst the COVID-19 Pandemic Antibiotics (IF 4.8) Pub Date : 2024-02-21 Hassan Al Mana, Hamad Abdel Hadi, Godwin Wilson, Muna A. Almaslamani, Sulieman H. Abu Jarir, Emad Ibrahim, Nahla O. Eltai
Antimicrobial resistance (AMR) is a global healthcare challenge with substantial morbidity, mortality, and management costs. During the COVID-19 pandemic, there was a documented increase in antimicrobial consumption, particularly for severe and critical cases, as well as noticeable travel and social restriction measures that might influenced the spectrum of AMR. To evaluate the problem, retrospective