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Correction to: An in vitro Assessment of Thermo-Reversible Gel Formulation Containing Sunitinib Nanoparticles for Neovascular Age-Related Macular Degeneration AAPS PharmSciTech (IF 3.3) Pub Date : 2024-03-14 Priyanka Bhatt, Priya Narvekar, Rohan Lalani, Mahavir Bhupal Chougule, Yashwant Pathak, Vijaykumar Sutariya
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Formulation, Characterization and In Vitro Evaluation of Mesalamine and Bifidobacterium bifidum Loaded Hydrogel Beads in Capsule System for Colon Targeted Delivery AAPS PharmSciTech (IF 3.3) Pub Date : 2024-03-14 Jagtar Singh, Mohit Sharma, Harmeet Singh, Pinky Arora, Puneet Utreja, Shubham Kumar
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Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c Mice AAPS PharmSciTech (IF 3.3) Pub Date : 2024-03-12 Kanwal Khalid, Hui Xuan Lim, Ayaz Anwar, Soon Hao Tan, Jung Shan Hwang, Seng-Kai Ong, Chit Laa Poh
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Utilization of Lipophilic Salt and Phospholipid Complex in Lipid-Based Formulations to Modulate Drug Loading and Oral Bioavailability of Pazopanib AAPS PharmSciTech (IF 3.3) Pub Date : 2024-03-12 Karan Jadhav, Arvind Sirvi, Akash Janjal, Mahesh C. Kashyap, Abhay T. Sangamwar
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Fabrication of 3D-Printed Hydrocortisone Triple Pulsatile Tablet Using Fused Deposition Modelling Technology AAPS PharmSciTech (IF 3.3) Pub Date : 2024-03-12 Hao Chen, Kai Zheng, Tianshi Bu, Xin Li, Xiangyu Wang, Hao Pan
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Development of Betulin-Loaded Nanostructured Lipid Carriers for the Management of Imiquimod-Induced Psoriasis AAPS PharmSciTech (IF 3.3) Pub Date : 2024-03-12 Prativa Biswasroy, Deepak Pradhan, Dilip Kumar Pradhan, Goutam Ghosh, Goutam Rath
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Simplex Lattice Design and Machine Learning Methods for the Optimization of Novel Microemulsion Systems to Enhance p-Coumaric Acid Oral Bioavailability: In Vitro and In Vivo Studies AAPS PharmSciTech (IF 3.3) Pub Date : 2024-03-06 Nayera Nasser, Rania M. Hathout, Hend Abd-Allah, Omaima A. Sammour
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Recent Trends in Nanocarrier-Based Drug Delivery System for Prostate Cancer AAPS PharmSciTech (IF 3.3) Pub Date : 2024-03-06 Amit Kumar, Akshay Kumar Lunawat, Ashutosh Kumar, Tarun Sharma, Md Moidul Islam, Milan Singh Kahlon, Debanjan Mukherjee, Raj Kumar Narang, Sarjana Raikwar
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Self-Nanoemulsion Intrigues the Gold Phytopharmaceutical Chrysin: In Vitro Assessment and Intrinsic Analgesic Effect AAPS PharmSciTech (IF 3.3) Pub Date : 2024-03-05 Samar Mohamed Elhoseny, Noha Mohamed Saleh, Mahasen Mohamed Meshali
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Novel Microemulsion Containing Benzocaine and Fusidic Acid Simultaneously: Formulation, Characterization, and In Vitro Evaluation for Wound Healing AAPS PharmSciTech (IF 3.3) Pub Date : 2024-03-05 Muhammet Davut Arpa, Emre Şefik Çağlar, Dilara Güreşçi, Hande Sipahi, Neslihan Üstündağ Okur
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Innovative Nanoparticulate Strategies in Colon Cancer Treatment: A Paradigm Shift AAPS PharmSciTech (IF 3.3) Pub Date : 2024-03-01 Rati Yadav, Rohit Bhawale, Vaibhavi Srivastava, Ekta Pardhi, Harshada Anil Bhalerao, Rajesh Sonti, Neelesh Kumar Mehra
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Quality-by-Design Based Development of Doxycycline Hyclate–Loaded Polymeric Microspheres for Prolonged Drug Release AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-29 Suraj Longre, Dhwani Rana, Shagun Rangra, Anil B. Jindal, Sagar Salave, Jyotsna Vitore, Derajram Benival
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Wurster Technology-Assisted Step-by-Step Engineering of Multi-layered Pellets (Sprinkles): Microscopy, Micro-CT, and e-Tongue-Based Analysis AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-29 Vishnu Datta Maremanda, Dirk Maertin, Malak Bitar, Abhijeet Pandey
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Nanocosmeceuticals: Trends and Recent Advancements in Self Care AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-29 Mitali Sethi, Rafquat Rana, Sharda Sambhakar, Manish K. Chourasia
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Nanocarrier-Mediated Drug Delivery via Inhalational Route for Lung Cancer Therapy: A Systematic and Updated Review AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-29 Nargis Ara, Abdul Hafeez
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Cutaneous Pharmacokinetics of Topically Applied Novel Dermatological Formulations AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-27 Meenakshi Patel, Ashwini Patel, Jagruti Desai, Swayamprakash Patel
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Using Dry Dispersion Laser Diffraction to Assess Dispersibility in Spheronized Agglomerate Formulations AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-23 Faustin Arevalo, Steven Tignor, Andrew Brunskill, Adrian Goodey
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Design of floating formulations and antiulcer activity of Desmostachya bipinnata AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-21
Abstract The study aims to design and optimize the floating formulations of the aqueous extract of Desmostachya bipinnata (ADB) to treat peptic ulcers. The trial concentrations of HPMC E50, HPMC K4M, and Carbopol 940 were used as factors, and floating lag time, total floating time, and % drug release at 12 h were used as responses. The formulation underwent evaluation for different parameters: aspirin-induced
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Liposomal Formulation Reduces Transport and Cell Uptake of Colistin in Human Lung Epithelial Calu-3 Cell and 3D Human Lung Primary Tissue Models AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-17 Yijing Huang, Shihui Yu, Maizbha Uddin Ahmed, Qi (Tony) Zhou
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Development of Aerosol Dry Powder Chemotherapeutic-Loaded Microparticles for the Treatment of Lung Cancer AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-17 Ryan Ivone, Ana Karabots, Samantha A. Meenach
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Drug Nanocrystals: A Delivery Channel for Antiviral Therapies AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-17 Akanksha Chaturvedi, Swapnil Sharma, Rahul Shukla
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Predicting Human Dermal Drug Concentrations Using PBPK Modeling and Simulation: Clobetasol Propionate Case Study AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-17 William W. van Osdol, Jasmina Novakovic, Maxime Le Merdy, Eleftheria Tsakalozou, Priyanka Ghosh, Jessica Spires, Viera Lukacova
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Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation—Where Are We Now? AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-14 Hemlata Patil, Sateesh Kumar Vemula, Sagar Narala, Preethi Lakkala, Siva Ram Munnangi, Nagarjuna Narala, Miguel O. Jara, Robert O. Williams, Hibreniguss Terefe, Michael A. Repka
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The Use of Data Mining for Obtaining Deeper Insights into the Fabrication of Prednisolone-Loaded Chitosan Nanoparticles AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-14
Abstract The present work explores a data mining approach to study the fabrication of prednisolone-loaded chitosan nanoparticles and their properties. Eight PLC formulations were prepared using an automated adaptation of the antisolvent precipitation method. The PLCs were characterized using dynamic light scattering, infrared spectroscopy, and drug release studies. Results showed that that the effective
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Excipients for Novel Inhaled Dosage Forms: An Overview AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-14 Carol Yousry, Mimansa Goyal, Vivek Gupta
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Comparison of Properties of Acetaminophen Tablets Prepared by Wet Granulation Using Freeze-Dried Versus Phase-Inversion Bacterial Cellulose as Diluent AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-08 Sirikanya Kaewpradit, Jiraporn Chingunpitak, Wannaphorn Samhadthai, Thanyanit Suppawattana, Chutima Jantarat
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Design and Evaluation of a Dual-Sensitive In Situ Gel for the Controlled Release of Pranoprofen AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-08
Abstract Currently, the marketed ophthalmic preparations of pranoprofen (PF) are mainly eye drops, but due to the special clearance mechanism of the eye and corneal reflex, the contact time between the drug and the focal site is short, most of the drug is lost, and the bioavailability is less than 5%. In the present study, an in situ gel eye drop containing no bacteriostatic agent and sensitive to
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Liquid Chromatography Tandem Mass Spectrometric Method for Quantification of Margetuximab in Rat Plasma and Application to a Pharmacokinetic Study AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-08 Pridhvi Krishna Gaddey, Raja Sundararajan
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Pharmacodynamic Studies of Pravastatin Sodium Nanoemulsion Loaded Transdermal Patch for Treatment of Hyperlipidemia AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-08 Seham I Elsayed, Marwa S El-Dahan, Germeen N. S Girgis
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Spray-Dried Mucoadhesive Re-dispersible Gargle of Chlorhexidine for Improved Response Against Throat Infection: Formulation Development, In Vitro and In Vivo Evaluation AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-07 Vineet Kumar Rai, Amresh Kumar, Deepak Pradhan, Jitu Halder, Tushar Kanti Rajwar, Manoj Kumar Sarangi, Priyanka Dash, Chandan Das, Salim Manoharadas, Biswakanth Kar, Goutam Ghosh, Goutam Rath
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Quercetin-Loaded Nanostructured Lipid Carrier In Situ Gel for Brain Targeting Through Intranasal Route: Formulation, In Vivo Pharmacokinetic and Pharmacodynamic Studies AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-05
Abstract Quercetin (QT) shows potential for protecting against neurodegenerative diseases like Alzheimer’s. However, its limited bioavailability and instability in physiological pH hinder its clinical use. The purpose of this work is to construct QT-filled nanostructured lipid carriers (QT-NLC) intranasal in situ gel to enhance pharmacokinetic and pharmacodynamic performance. NLCs were developed using
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Enhanced Oral Bioavailability of Progesterone in Bilosome Formulation: Fabrication, Statistical Optimization, and Pharmacokinetic Study AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-01 Ronak Maheshwari, Lokesh Kumar Bhatt, Sarika Wairkar
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Rapidly Dissolving Trans-scleral Microneedles for Intraocular Delivery of Cyclosporine A AAPS PharmSciTech (IF 3.3) Pub Date : 2024-02-01
Abstract Cyclosporine A (CsA) is a cyclic peptide immunosuppressant drug that is beneficial in the treatment of various ocular diseases. However, its ocular bioavailability in the posterior eye is limited due to its poor aqueous solubility. Conventional CsA formulations such as a solution or emulsion permeate poorly across the eye due to various static and dynamic barriers of the eye. Dissolvable microneedle
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Development of a PVA/PCL/CS-Based Nanofibrous Membrane for Guided Tissue Regeneration and Controlled Delivery of Doxycycline Hydrochloride in Management of Periodontitis: In Vivo Evaluation in Rats AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-30 Shahla Mirzaeei, Shadman Pourfarzi, Morteza Saeedi, Shiva Taghe, Ali Nokhodchi
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Changes in Tablet Color Due to Light Irradiation: Photodegradation of the Coating Polymer, Hypromellose, by Titanium Dioxide AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-25 Yuki Matsushima, Masaki Hattori, Akiko Tanaka, Tomoyuki Furubayashi, Toshiyasu Sakane
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Targeted Nanoparticles: the Smart Way for the Treatment of Colorectal Cancer AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-24 Ahmed A. H. Abdellatif, Abdulmajeed S. Alshubrumi, Mahmoud A. Younis
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Screening of Organic Small Molecule Excipients on Ternary Solid Dispersions Based on Miscibility and Hydrogen Bonding Analysis: Experiments and Molecular Simulation AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-24 Sidian Zhang, Huaqi Wang, Xiuying Zhao, Haiyan Xu, Sizhu Wu
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Determining the Impact of Roller Compaction Processing Conditions on Granulate and API Properties: Impact of Formulation API Load AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-24
Abstract Previous work demonstrated that roller compaction of a 40%w/w theophylline–loaded formulation resulted in granulate consisting of un-compacted fractions which were shown to constitute between 34 and 48%v/v of the granulate dependent on processing conditions. The active pharmaceutical ingredient (API) primary particle size within the un-compacted fraction was also shown to have undergone notable
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Anti-CD64 Antibody-Conjugated PLGA Nanoparticles Containing Methotrexate and Gold for Theranostics Application in Rheumatoid Arthritis AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-24 Sahil Gandhi, Pravin Shende
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Patient In-Use Stability Testing of FDA-Approved Metformin Combination Products for N-Nitrosamine Impurity AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-24 Sathish Dharani, Eman M. Mohamed, Ziyaur Rahman, Mansoor A. Khan
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Antibacterial and Antioxidant Study of New Pharmaceutical Formulation of Didecyldimethylammonium Bromide Via Pharmaceutical Deep Eutectic Solvents (PDESs) Principle AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-24 Idrees B. Qader, Aryan R. Ganjo, Hiwa O. Ahmad, Hemn A. Qader, Hewa A. Hamadameen
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In Vitro and In Vivo testing of 3D-Printed Amorphous Lopinavir Printlets by Selective Laser Sinitering: Improved Bioavailability of a Poorly Soluble Drug AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-24 Canberk Kayalar, Nada Helal, Eman M. Mohamed, Sathish Dharani, Tahir Khuroo, Mathew A. Kuttolamadom, Ziyaur Rahman, Mansoor A. Khan
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Self-assembling Organogels Loaded with Tenoxicam for Local Intensive Pain and Inflammation Cure: In Vitro and In Vivo Correlation AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-23 Shaaban K. Osman, Taher M. Yassin, Arafat Abdelzaher, Fatma Ahmed, Ahmed M. Mohammed, Ahmed A. H. Abdellatif, Khalid I. Saleh, Wael A. Mahdi, Sultan Alshehri, Mohamed A. El Hamd, Hatem Sarhan
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Insights into Translational and Biomedical Applications of Hydrogels as Versatile Drug Delivery Systems AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-22
Abstract Hydrogels are a network of crosslinked polymers which can hold a huge amount of water in their matrix. These might be soft, flexible, and porous resembling living tissues. The incorporation of different biocompatible materials and nanostructures into the hydrogels has led to emergence of multifunctional hydrogels with advanced properties. There are broad applications of hydrogels such as tissue
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Mefenamic Acid Loaded and TPGS Stabilized Mucoadhesive Nanoemulsion for the Treatment of Alzheimer’s Disease: Development, Optimization, and Brain-Targeted Delivery via Olfactory Pathway AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-10 Anmol Dogra, Ramandeep Singh Narang, Tajpreet Kaur, Jasjeet Kaur Narang
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Co-emulsified Alginate-Eudragit Nanoparticles: Potential Carriers for Localized and Time-defined Release of Tenofovir in the Female Genital Tract AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-10 Funanani Takalani, Pradeep Kumar, Pierre P. D. Kondiah, Yahya E. Choonara
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Development and Characterization of Modified Chitosan Lipopolyplex for an Effective siRNA Delivery AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-08 Shibani Supe, Archana Upadhya, Vikas Dighe, Kavita Singh
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A Quality by Design Approach for Developing SNEDDS Loaded with Vemurafenib for Enhanced Oral Bioavailability AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-08 Chakradhar JVUS, Naresh Kothuri, Sanjay Singh, Sonia Verma, Hasham Shafi, D. V. Siva Reddy, Ashwini Kedar, Rafquat Rana, Keerti Mishra, Deepak Sharma, Manish K. Chourasia
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A Rapid 3-Day Excipient Screening Methodology and its Application in Identifying Chemical Stabilizers for Solid Formulations with Mixed Mechanisms of Degradation AAPS PharmSciTech (IF 3.3) Pub Date : 2024-01-05 Amol S. Matharu, Sundeep S. Dhareshwar, Yu (Jade) Cao
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Influence of Crystal Disorder on the Forced Oxidative Degradation of Vortioxetine HBr AAPS PharmSciTech (IF 3.3) Pub Date : 2023-12-29 Dattatray Modhave, Brenda Barrios, Jayant Iyer, Amrit Paudel
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Effects of Apex Size on Dissolution Profiles in the USP II Paddle Apparatus AAPS PharmSciTech (IF 3.3) Pub Date : 2023-12-29 Hiroyuki Yoshida, Tokio Morita, Yasuhiro Abe, Aoi Inagaki, Naomi Tomita, Ken-ichi Izutsu, Yoji Sato
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Design and Evaluation of Ginkgolides Gastric Floating Controlled Release Tablets Based on Solid Supersaturated Self-nanoemulsifying AAPS PharmSciTech (IF 3.3) Pub Date : 2023-12-26 Kai Zheng, Jing Zhao, Qiuli Wang, Yuyang Zhao, Husheng Yang, Xinggang Yang, Lian He
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A Colourful Way to Unravel the Important Fluidization-Related Granule Size Effect on Semi-Continuous Drying AAPS PharmSciTech (IF 3.3) Pub Date : 2023-12-29 Tuur Vandeputte, Michael Ghijs, Ingmar Nopens, Thomas De Beer
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Dissolution Profiles Comparison Using Conventional and Bias Corrected and Accelerated f2 Bootstrap Approaches with Different Software’s: Impact of Variability, Sample Size and Number of Bootstraps AAPS PharmSciTech (IF 3.3) Pub Date : 2023-12-20 Rajkumar Boddu, Sivacharan Kollipara, Adithya Karthik Bhattiprolu, Karthik Parsa, Sanketh Kumar Chakilam, Krishna Reddy Daka, Ashima Bhatia, Tausif Ahmed
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Potential Applications and Additive Manufacturing Technology-Based Considerations of Mesoporous Silica: A Review AAPS PharmSciTech (IF 3.3) Pub Date : 2023-12-21 Jigar Vyas, Sudarshan Singh, Isha Shah, Bhupendra G. Prajapati
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Evaluation of Dose-Response Relationship of Permeation Enhancer Isopropyl Myristate Release on Drug Release: Release Enhancement Efficiency and Molecular Mechanism AAPS PharmSciTech (IF 3.3) Pub Date : 2023-12-19 Jiuheng Ruan, Sida Liao, Jinye Tang, Liang Fang
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Preparation of Tetrandrine Nanocrystals by Microfluidic Method and Its In Vitro and In Vivo Evaluation AAPS PharmSciTech (IF 3.3) Pub Date : 2023-12-19 Jinping Huang, Shuwen Huang, Shengjun Liu, Lizhen Feng, Wenxiu Huang, Yao Wang, Dongyi Huang, Tingting Huang, Xingzhen Huang
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Separable and Inseparable Silk Fibroin Microneedles for the Transdermal Delivery of Colchicine: Development, Characterization, and Comparisons AAPS PharmSciTech (IF 3.3) Pub Date : 2023-12-19 Shiji Liao, Guirong Qiu, Yanping Hu, Bohong Guo, Yuqin Qiu
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In Vivo Cancer Microenvironment Responsive Glycan Receptor-Targeted Nanoparticles for Gemcitabine Delivery to Benzo[a]pyrene-Induced Lung Cancer Model AAPS PharmSciTech (IF 3.3) Pub Date : 2023-12-19 Krishan Kumar, Rinki Verma, Manjit, Priya, Mohini Mishra, Varsha Rani, Ruchi Chawla
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Recent Advances of Multifunctional PLGA Nanocarriers in the Management of Triple-Negative Breast Cancer AAPS PharmSciTech (IF 3.3) Pub Date : 2023-12-14 Yirivinti Hayagreeva Dinakar, Naveen Rajana, Nalla Usha Kumari, Vikas Jain, Neelesh Kumar Mehra