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Imatinib@glycymicelles entrapped in hydrogel: preparation, characterization, and therapeutic effect on corneal alkali burn in mice Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-17 Yanan Wang, Shaohua Shi, Ling Zhang, Songtao Wang, Hongqing Qin, Yanjun Wei, Xianggen Wu, Mengmeng Zhang
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OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-13 Nicola d’Avanzo, Donatella Paolino, Antonella Barone, Luigi Ciriolo, Antonia Mancuso, Maria Chiara Christiano, Anna Maria Tolomeo, Christian Celia, Xiaoyong Deng, Massimo Fresta
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Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-12
Abstract The utilization of 3D printing– digital light processing (DLP) technique, for the direct fabrication of microneedles encounters the problem of drug solubility in printing resin, especially if it is predominantly composed of water. The possible solution how to ensure ideal belonging of drug and water-based printing resin is its pre-formulation in nanosuspension such as nanocrystals. This study
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Cyclosporin A-loaded dissolving microneedles for dermatitis therapy: Development, characterisation and efficacy in a delayed-type hypersensitivity in vivo model Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-12 Miquel Martínez-Navarrete, Antonio José Guillot, Maria C. Lobita, María Carmen Recio, Rosa Giner, Juan Aparicio-Blanco, María Carmen Montesinos, Hélder A. Santos, Ana Melero
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Formulation, pharmacokinetics, and antibacterial activity of florfenicol-loaded niosome Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-04-01 Shimaa G. Abonashey, Hatem A. F. M. Hassan, Mostafa A. Shalaby, Amr Gamal Fouad, Elham Mobarez, Hossny A. El-Banna
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Dynamic intervention to enhance the stability of PEGylated Ibrutinib loaded lipidic nano-vesicular systems: transitioning from colloidal dispersion to lyophilized product Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-08 Kanan Panchal, Akhila Reddy, Rishi Paliwal, Akash Chaurasiya
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Oxaliplatin lipidated prodrug synergistically enhances the anti-colorectal cancer effect of IL12 mRNA Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-08
Abstract Colorectal cancer (CRC) is the fourth most common cancer in the world, with the second highest incidence rate after lung cancer. Oxaliplatin (OXA) is a broad-spectrum anti-tumor agent with significant therapeutic efficacy in colorectal cancer, and as a divalent platinum analog, it is not selective in its distribution in the body and has systemic toxicity with continued use. Interleukin-12
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Nanocrystals and nanosuspensions: an exploration from classic formulations to advanced drug delivery systems Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-07 Benjamin Rossier, Olivier Jordan, Eric Allémann, Carlos Rodríguez-Nogales
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Liver fibrosis pathologies and potentials of RNA based therapeutics modalities Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-06
Abstract Liver fibrosis (LF) occurs when the liver tissue responds to injury or inflammation by producing excessive amounts of scar tissue, known as the extracellular matrix. This buildup stiffens the liver tissue, hinders blood flow, and ultimately impairs liver function. Various factors can trigger this process, including bloodborne pathogens, genetic predisposition, alcohol abuse, non-steroidal
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Insulin Delivery to the Brain via the Nasal Route: Unraveling the Potential for Alzheimer's Disease Therapy Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-05 Chun Yuen Jerry Wong, Alberto Baldelli, Camilla M. Hoyos, Ole Tietz, Hui Xin Ong, Daniela Traini
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Innovative freeze-drying technique in the fabrication of dissolving microneedle patch: Enhancing transdermal drug delivery efficiency Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-02 Tong Su, Zequn Tang, Jiayi Hu, Yuyu Zhu, Teng Shen
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Preparation and characterization of Sorafenib nano-emulsion: impact on pharmacokinetics and toxicity; an in vitro and in vivo study Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-02 Dalia Zaafar, Heba M. A. Khalil, Gehad E. Elkhouly, Abanoub Selim Sedeky, Yasmine H. Ahmed, Mona G. Khalil, Yasmin Abo-zeid
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PLGA-PEI nanoparticle covered with poly(I:C) for personalised cancer immunotherapy Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-03-01 Lorena Gonzalez-Melero, Edorta Santos-Vizcaino, Ruben Varela-Calvino, Iria Gomez-Tourino, Aintzane Asumendi, Maria Dolores Boyano, Manoli Igartua, Rosa Maria Hernandez
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Simple preparation and greatly improved oral bioavailability: The supersaturated drug delivery system of quercetin based on PVP K30 Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-29 Manzhen Li, Haowen Li, Likang Lu, Jingxin Fu, Hui Ao, Meihua Han, Yifei Guo, Hongda Zhang, Zhenzhong Wang, Xiangtao Wang
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Correction to: Domperidone nanocrystals with boosted oral bioavailability: fabrication, evaluation and molecular insight into the polymer-domperidone nanocrystal interaction Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-28 Stalielson Tatenda Ndlovu, Naseem Ullah, Shahzeb Khan, Pritika Ramharack, Mahmoud Soliman, Marcel de Matas, Muhammad Shahid, Muhammad Sohail, Muhammad Imran, Syed Wadood Ali Shah, Zahid Hussain
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Effects of excipients on the interactions of self-emulsifying drug delivery systems with human blood plasma and plasma membranes Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-27 Bao Le-Vinh, Nguyet-Minh Nguyen Le, Thi Nhu Quynh Phan, Hung Thanh Lam, Andreas Bernkop-Schnürch
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Chitosan nanoparticles laden contact lenses for enzyme-triggered controlled delivery of timolol maleate: A promising strategy for managing glaucoma Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-26 Furqan A. Maulvi, Ashmi R. Patel, Kiran H. Shetty, Ditixa T. Desai, Dinesh O. Shah, Mark D. P. Willcox
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Correction to: The effects of superparamagnetic iron oxide nanoparticles-labeled mesenchymal stem cells in the presence of a magnetic field on attenuation of injury after heart failure Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-22 Maryam Naseroleslami, Nahid Aboutaleb, Kazem Parivar
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Inhaled delivery of cetuximab-conjugated immunoliposomes loaded with afatinib: A promising strategy for enhanced non-small cell lung cancer treatment Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-21 Sha Liu, Daoyuan Chen, Xiaosu Zhu, Xiaowen Wang, Xiao Li, Yuan Du, Peng Zhang, Jingwei Tian, Yingjian Song
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Nose to brain delivery of mirtazapine via lipid nanocapsules: Preparation, statistical optimization, radiolabeling, in vivo biodistribution and pharmacokinetic study Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-20 Mennatullah M. Ibrahim, Emad B. Basalious, Mohamed A. El-Nabarawi, Amal IA. Makhlouf, Marwa Eid Sayyed, Ismail Taha Ibrahim
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Correction: Partial inclusion complex assisted crosslinked β-cyclodextrin nanoparticles for improving therapeutic potential of docetaxel against breast cancer Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-19 Sanyog Jain, Mahesh R. Desai, Bhargavi Nallamothu, Kaushik Kuche, Dasharath Chaudhari, Sameer S. Katiyar
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A comparative study of passive drug diffusion through human skin via intercellular and sweat duct route: effect of aging Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-16
Abstract A method of drug delivery that could provide control over medicine reaching the bloodstream for systemic circulation would be of immense importance. This work presents a comparative study of the temporal and spatial variation of drugs diffusing passively through two separate routes of human skin, namely intercellular (ICR) and sweat duct route (SDR). An analysis is carried out for two age
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Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-15
Abstract Skin cancer is a widespread type of cancer representing 30% of all cancer types worldwide. Resveratrol (RSV) is an anticancer drug used for skin cancer treatment. Several limitations of RSV such as poor aqueous solubility, first-pass metabolism, and instability limit their topical use. The study aimed to develop and optimize RSV-loaded invasomes for topical administration as well as assess
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Mirtazapine loaded polymeric micelles for rapid release tablet: A novel formulation—In vitro and in vivo studies Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-14
Abstract Major depression is a prevalent disorder characterized by sadness, lack of interest or pleasure, interrupted sleep or food, and impaired concentration. Mirtazapine (MTZ), a tetracyclic antidepressant drug, is commonly used to treat moderate to severe depression. MTZ is classified as a BCS class II drug that has shown bioavailability of 50% due to extensive first-pass metabolism. The aim of
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Precise control of microfluidic flow conditions is critical for harnessing the in vitro transfection capability of pDNA-loaded lipid-Eudragit nanoparticles Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-12 Diviya Santhanes, Huiming Zhang, Alex Wilkins, Robert John Aitken, Anne-Louise Gannon, Mingtao Liang
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Antibiotic resistance and tolerance: What can drug delivery do against this global threat? Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-10 Juan Aparicio-Blanco, Nikhar Vishwakarma, Claus-Michael Lehr, Clive A. Prestidge, Nicky Thomas, Richard J. Roberts, Chelsea R. Thorn, Ana Melero
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Metal organic framework–based variable-size nanoparticles for tumor microenvironment-responsive drug delivery Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-08 Yu Wang, Nan Gao, Xiaodan Li, Guixia Ling, Peng Zhang
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State of the art in pediatric nanomedicines Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-07
Abstract In recent years, the continuous development of innovative nanopharmaceuticals is expanding their biomedical and clinical applications. Nanomedicines are being revolutionized to circumvent the limitations of unbound therapeutic agents as well as overcome barriers posed by biological interfaces at the cellular, organ, system, and microenvironment levels. In many ways, the use of nanoconfigured
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Local administration of irinotecan using an implantable drug delivery device stops high-grade glioma tumor recurrence in a glioblastoma tumor model Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-06 Dina Abdelnabi, Sarah Lastakchi, Colin Watts, Hannah Atkins, Shawn Hingtgen, Alain Valdivia, Christopher McConville
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Capped flexosomes for prominent anti-inflammatory activity: development, optimization, and ex vivo and in vivo assessments Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-05 Sadek Ahmed, Diana E. Aziz, Mohamed A. Sadek, Mai Ahmed Tawfik
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Exosome: From biology to drug delivery Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-22
Abstract In recent years, different advancements have been observed in nanosized drug delivery systems. Factors such as stability, safety and targeting efficiency cause hindrances in the clinical translation of these synthetic nanocarriers. Therefore, researchers employed endogenous nanocarriers like exosomes as drug delivery vehicles that have an inherent ability to target more efficiently after appropriate
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Green synthesis of anti-cancer drug-loaded gold nanoparticles for low-intensity pulsed ultrasound targeted drug release Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-19 Anshuman Jakhmola, Tyler K. Hornsby, Farshad Moradi Kashkooli, Michael C. Kolios, Kevin Rod, Jahangir (Jahan) Tavakkoli
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Toward a solid microneedle patch for rapid and enhanced local analgesic action Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-18 Yue Liu, Ze Qiang Zhao, Ling Liang, Li Yue Jing, Jianhao Wang, Yun Dai, Bo Zhi Chen, Xin Dong Guo
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Anti-tumor therapy of glycyrrhetinic acid targeted liposome co-delivery of doxorubicin and berberine for hepatocellular carcinoma Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-18 Na Xu, Jingliang Wu, Weihao Wang, Shujie Sun, Mengmeng Sun, Yandong Bian, Huien Zhang, Shuzhen Liu, Guohua Yu
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Storage stability of lysostaphin solution and its pulmonary delivery Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-17
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) has become a leading causative pathogen of nosocomial pneumonia with an alarming in-hospital mortality rate of 30%. Last resort antibiotic, vancomycin, has been increasingly used to treat MRSA infections, but the rapid emergence of vancomycin-resistant strains urges the development of alternative treatment strategies against MRSA-associated
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Nanoemulsions and nanocapsules loaded with Melaleuca alternifolia essential oil for sepsis treatment Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-16
Abstract Sepsis represents a complex clinical syndrome that results from a harmful host response to infection. The infections most associated with sepsis are pneumonia, intra-abdominal infection, and urinary tract infection. Tea tree oil (TTO) has shown high antibacterial activity; however, it exhibits low aqueous solubility and high volatility, which have motivated its nanoencapsulation. In this study
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Research progress on nanotechnology of traditional Chinese medicine to enhance the therapeutic effect of osteoarthritis Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-15 Yue Peng, Zhengshuang Yang, Jinling Li, Sijia Liu
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Advancements in microneedle fabrication techniques: artificial intelligence assisted 3D-printing technology Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-13 Anuj A. Biswas, Madhukiran R. Dhondale, Ashish K. Agrawal, Dolores R. Serrano, Brahmeshwar Mishra, Dinesh Kumar
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Development of polysaccharide-coated layered double hydroxide nanocomposites for enhanced oral insulin delivery Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-12 Huiwen Pang, Youzhi Wu, Yang Chen, Chen Chen, Xuqiang Nie, Peng Li, Guojun Huang, Zhi Ping Xu, Felicity Y. Han
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Intra-articular injection of stigmasterol-loaded nanoparticles reduce pain and inhibit the inflammation and joint destruction in osteoarthritis rat model: A pilot study Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-10 Ji Hyun Lim, Sung Eun Kim, Hak-Jun Kim, Gwan Gyu Song, Jae Hyun Jung
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pH and redox dual response nano-suppository for the treatment of ulcerative colitis Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-08
Abstract To improve treatment compliance and reach sustained and controlled drug release in the colon, we developed a hollow mesoporous silica nano-suppository that responded to both pH and redox stimuli. Firstly, we prepared hollow mesoporous silica nanoparticles containing disulfide bonds (HMSN-SS) and loaded them with 5-ASA. Secondly, we modified the surface of HMSN-SS with polydopamine (PDA) and
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Febuxostat ternary inclusion complex using SBE7-βCD in presence of a water-soluble polymer: physicochemical characterization, in vitro dissolution, and in vivo evaluation Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-07 Wedad Sakran, Mai Abdel-Hakim, Mohammed S. Teiama, Rania S. Abdel-Rashid
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3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-07 Elena Munoz-Perez, J. Rubio-Retama, Lorena Cussó, Manoli Igartua, Rosa Maria Hernandez, Edorta Santos-Vizcaino
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Targeted liposomes for macrophages-mediated pulmonary fibrosis therapy Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-02 Yujie Wang, Fang Zhao, Xiangyu Wang, Haojie Zuo, Yiming Ru, Xi Cao, Yang Wang
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Novel PEGylated cholephytosomes for targeting fisetin to breast cancer: in vitro appraisal and in vivo antitumoral studies Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-02-01 Sara M. Talaat, Yosra S. R. Elnaggar, Mennatallah A. Gowayed, Samar O. El-Ganainy, Maram Allam, Ossama Y. Abdallah
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The selection of animal models influences the assessment of anti-tumor efficacy: promising sialic acid-conjugate modified liposomes demonstrate remarkable therapeutic effects in diverse mouse strains Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2024-01-02 Lu Wei, Lin Lin, Jia Wang, Xinying Guan, Wen Li, Yangxu Gui, Shupei Liao, Mingyang Wang, Jiaqi Li, Yihui Deng, Yanzhi Song
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Efficiency of PGK1 proteins delivered to the brain via a liposomal system through intranasal route administration for the treatment of spinocerebellar ataxia type 3 Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-31 Yu-Shuan Chen, Zhen-Xiang Hong, Yi-Tung Lin, En-CI Tsao, Pei-Yu Chen, Ching-Ann Liu, Horng-Jyh Harn, Tzyy-Wen Chiou, Shinn-Zong Lin
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LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-31 Yali Xu, Zhixin Qiu, Jinwen Chen, Lihong Huang, Jiaqi Zhang, Junshan Lin
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Data-driven development of an oral lipid-based nanoparticle formulation of a hydrophobic drug Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-29 Zeqing Bao, Fion Yung, Riley J. Hickman, Alán Aspuru-Guzik, Pauric Bannigan, Christine Allen
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Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex vivo, and in vivo studies in rat model via modulation of RANKL/OPG Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-29
Abstract Osteoarthritis is a bone and joint condition characterized pathologically by articular cartilage degenerative damage and can develop into a devastating and permanently disabling disorder. This investigation aimed to formulate the anti-inflammatory drug lornoxicam (LOR) into bile salt–enriched vesicles loaded in an in situ forming hydrogel as a potential local treatment of osteoarthritis. This
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Design of nanoparticle-based systems for the systemic delivery of chemotherapeutics: Alternative potential routes via sublingual and buccal administration for systemic drug delivery Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-27 Kiana Bahrami, Elaine Lee, Brinkley Morse, Olivia L. Lanier, Nicholas A. Peppas
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Correction to: Polycaprolactone microparticles for the subcutaneous administration of cannabidiol: in vitro and in vivo release Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-22 Ana Isabel Fraguas-Sánchez, Dolores Hernán Pérez de la Ossa, Consuelo Montejo, Justin L. Poklis, Aron H. Lichtman, Ana Isabel Torres-Suárez
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Co-delivery of indomethacin and uricase as a new strategy for inflammatory diseases associated with high uric acid Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-21 Jie Liu, Chenshi Lin, Man Wu, Yingjie Wang, Shenyu Chen, Taiwang Yang, Chenlu Xie, Yue Kong, Wenliang Wu, Jiaping Wang, Xiaonan Ma, Chao Teng
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Cell-derived biomimetic nanoparticles for the targeted therapy of ALI/ARDS Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-20 Rui Gao, Peihong Lin, Zhengyu Fang, Wenjing Yang, Wenyan Gao, Fangqian Wang, Xuwang Pan, Wenying Yu
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Enhancement of dissolution and oral bioavailability by adjusting microenvironment pH in crocetin ternary solid dispersions: Optimization, characterization, in vitro evaluation, and pharmacokinetics Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-20 Zheren Tong, Xianyin Liu, Yi Tao, Peishi Feng, Fujia Luan, Xiaolu Jie, Zhangfu Xie, Faxiang Pu, Zijin Xu, Ping Wang
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ApoE—functionalization of nanoparticles for targeted brain delivery—a feasible method for polyplexes? Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-12 Natascha Hartl, Bettina Gabold, Philipp Uhl, Adrian Kromer, Ximian Xiao, Gert Fricker, Walter Mier, Runhui Liu, Olivia M. Merkel
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Design of a tulobuterol patch with improved mechanical properties: effect of transdermal permeation enhancers on the release process of metal ligand-based acrylic pressure-sensitive adhesives Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-12 Longyi Nan, Haoyuan Song, Haijun Wang, Ru Mi, Xiaoxu Wang, Liang Fang
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Small molecule–engineered nanoassembly for lipid peroxidation–amplified photodynamic therapy Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-12 Yuting Wang, Yuequan Wang, Yuting Liu, Mingyang Zhou, Xianbao Shi, Xiaohui Pu, Zhonggui He, Shenwu Zhang, Feng Qin, Cong Luo
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Enhancing transmucosal delivery of CBD through nanoemulsion: in vitro and in vivo studies Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-08 Romina Provenzano, Carmen De Caro, Antonella Vitiello, Luana Izzo, Alberto Ritieni, Francesca Ungaro, Fabiana Quaglia, Emilio Russo, Agnese Miro, Ivana d’Angelo
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Multicellular tumor spheroid model to study the multifaceted role of tumor-associated macrophages in PDAC Drug Deliv. Transl. Res. (IF 5.4) Pub Date : 2023-12-07 Nadège Bidan, Garett Dunsmore, Martina Ugrinic, Mathilde Bied, Marco Moreira, Claudine Deloménie, Florent Ginhoux, Camille Blériot, Maria de la Fuente, Simona Mura