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Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery Curr. Drug Targets (IF 3.2) Pub Date : 2024-03-08 Hossamaldeen Bakrey, Riya Shivgotra, Abdulkadir Abdu, Bindu Soni, Navid Reza Shahtaghia, Subheet Kumar Jain, Shubham Thakur
: Total Parenteral Nutrition (TPN) is a method of providing nutrients directly into the bloodstream for individuals who are unable to meet their nutritional needs through the normal digestive process or gastrointestinal system. It provides macronutrients and micronutrients in a single container, reducing handling and contamination risks and making it more cost-effective. TPN has the potential to be
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Surface Functionalized Lipid Nanoparticles in Promoting Therapeutic Outcomes: An Insight View of the Dynamic Drug Delivery System Curr. Drug Targets (IF 3.2) Pub Date : 2024-02-22 Namish Manchanda, Harish Vishkarma, Muskan Goyal, Saurabh Shah, Paras Famta, Sushama Talegaonkar, Saurabh Srivastava
Compared to the conventional approach, nanoparticles (NPs) facilitate a non-hazardous, non-toxic, non-interactive, and biocompatible system, rendering them incredibly promising for improving drug delivery to target cells. When that comes to accomplishing specific therapeutic agents like drugs, peptides, nucleotides, etc., lipidic nanoparticulate systems have emerged as even more robust. They have asserted
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Current Insights into Carpal Tunnel Syndrome: Clinical Strategies for Prevention and Treatment Curr. Drug Targets (IF 3.2) Pub Date : 2024-02-21 Rishabh Chaudhary, Janvi khanna, Seema Bansal, Nitin Bansal
Background: Carpal tunnel syndrome (CTS) is a condition that is caused by medial nerve compression, resulting in symptoms such as numbness, tightness, or weakness in the hand. Objectives: The aim of the study was to find out the genetic modulation, mechanism, available treatment, and recommendation for carpal tunnel syndrome at its specific stage. Methods: Almost 200 papers were searched for this review
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Recent Advances in Biomedical Applications of Mannans and Xylans Curr. Drug Targets (IF 3.2) Pub Date : 2024-02-19 Shriya Teli, Kajal Deshmukh, Tabassum Khan, Vasanti Suvarna
Plant-based phytochemicals, including flavonoids, alkaloids, tannins, saponins, and other metabolites, have attracted considerable attention due to their central role in synthesizing nanomaterials with various biomedical applications. Hemicelluloses are the second most abundant among naturally occurring heteropolymers, accounting for one-third of all plant constituents. In particular, xylans, mannans
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Quantum Dot-based Bio-conjugates as an Emerging Bioimaging Tool for Cancer Theranostic- A Review Curr. Drug Targets (IF 3.2) Pub Date : 2024-01-26 Lipika Priya, Smit Mehta, Darshan Gevariya, Raghav Sharma, Drishti Panjwani, Shruti Patel, Priyanka Ahlawat, Abhay Dharamsi, Asha Patel
Cancer is the most widely studied disorder in humans, but proper treatment has not yet been developed for it. Conventional therapies, like chemotherapy, radiation therapy, and surgery, have been employed. Such therapies target not only cancerous cells but also harm normal cells. Conventional therapy does not result in specific targeting and hence leads to severe side effects. The main objective of
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Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies Curr. Drug Targets (IF 3.2) Pub Date : 2024-01-23 Ibukun O. Oresanya, Ilkay Erdogan Orhan
: Rosmarinus officinalis L. (RO, rosemary) is a well-known medicinal, aromatic, and culinary herb with traditional use in European folk medicine against memory deficits and neurodegenerative disorders. This review highlights the different neuroprotective activities of RO investigated in both preclinical and clinical studies, as well as in silico molecular docking of bioactive compounds found in RO
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An Updated Insight into Phytomolecules and Novel Approaches used in the Management of Breast Cancer Curr. Drug Targets (IF 3.2) Pub Date : 2024-01-12 Zulfa Nooreen, Sudeep Tandon, Ankita Wal, Awani Kumar Rai
Breast cancer is a widespread condition that kills more women from cancer-related causes than any other type of cancer globally. Women who have estrogen-dependent, initial metastatic breast cancer frequently receive treatment with surgery, radiation therapy, and chemotherapy. They may also get more specialized treatments like tamoxifen or aromatase inhibitors (anastrozole or letrozole). The World Health
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Molecular Targets and Mechanisms of Hedyotis diffusa Willd. for Esophageal Adenocarcinoma Treatment Based on Network Pharmacology and Weighted Gene Co-expression Network Analysis Curr. Drug Targets (IF 3.2) Pub Date : 2024-01-12 Yu Zhuang, Yun-Gang Sun, Chen-Guang Wang, Qiang Zhang, Chao Che, Feng Shao
Background:: Hedyotis diffusa Willd. (HDW) is a common anticancer herbal medicine in China, and its therapeutic effectiveness has been demonstrated in a range of cancer patients. There is no consensus about the therapeutic targets and molecular mechanisms of HDW, which contains many active ingredients. Aim:: To clarify the mechanism of HDW for esophageal adenocarcinoma (EAC), we utilized network pharmacology
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A Review on the Recent Advancements and Artificial Intelligence in Tablet Technology Curr. Drug Targets (IF 3.2) Pub Date : 2024-01-12 Amit Sahu, Sunny Rathee, Shivani Saraf, Sanjay K. Jain
Background:: Tablet formulation could be revolutionized by the integration of modern technology and established pharmaceutical sciences. The pharmaceutical sector can develop tablet formulations that are not only more efficient and stable but also patient-friendly by utilizing artificial intelligence (AI), machine learning (ML), and materials science. Objectives:: The primary objective of this review
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Cytokines and Regulating Epithelial Cell Division Curr. Drug Targets (IF 3.2) Pub Date : 2024-01-11 Basheer Abdullah Marzoog
Physiologically, cytokines play an extremely important role in maintaining cellular and subcellular homeostasis, as they interact almost with every cell in the organism. Therefore, cytokines play a significantly critical role in the field of pathogenic pharmacological therapy of different types of pathologies. Cytokine is a large family containing many subfamilies and can be evaluated into groups according
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Targeting Protein Phosphatases for the Treatment of Chronic Liver Disease Curr. Drug Targets (IF 3.2) Pub Date : 2024-01-11 Yi-Ming Li, Hong-Wei He, Na Zhang
There exists a huge number of patients suffering from chronic liver disease worldwide. As a disease with high incidence and mortality worldwide, strengthening the research on the pathogenesis of chronic liver disease and the development of novel drugs is an important issue related to the health of all human beings. Phosphorylation modification of proteins plays a crucial role in cellular signal transduction
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Efficacy and Possible Mechanisms of Astragali Radix and its Ingredients in Animal Models of Osteoporosis: A Preclinical Review and Metaanalysis Curr. Drug Targets (IF 3.2) Pub Date : 2024-01-11 Ning Cao, Zhangxuan Shou, Yi Xiao, Puqing Liu
Abstract: Background: Astragali Radix (AR) has a long history as a traditional Chinese medicine for anti-osteoporosis (OP) treatment. The aim of the study was to explore the effect and optimal regimens of AR and its main ingredients (IAR) in OP treatment. Methods: Eligible animal studies were searched in seven databases (PubMed, Web of Science, MEDLINE, SciELO Citation Index, Cochrane Library, China
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Exploring the Efficient Natural Products for the Therapy of Parkinson’s Disease via Drosophila Melanogaster (Fruit Fly) Models Curr. Drug Targets (IF 3.2) Pub Date : 2024-01-10 Wen Zhang, Yingjie Ju, Yunuo Ren, Yaodong Miao, Yiwen Wang
Parkinson's disease (PD) is a severe neurodegenerative disorder, partly attributed to mutations, environmental toxins, oxidative stress, abnormal protein aggregation, and mitochondrial dysfunction. However, the precise pathogenesis of PD and its treatment strategy still require investigation. Fortunately, natural products have demonstrated potential as therapeutic agents for alleviating PD symptoms
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Bile Acid Application in Cell-Targeting for Molecular Receptors in Relation to Hearing: A Comprehensive Review Curr. Drug Targets (IF 3.2) Pub Date : 2024-01-08 Corina M. Ionescu, Melissa A. Jones, Susbin R Wagle, Bozica Kovacevic, Thomas Foster, Momir Mikov, Armin Mooranian, Hani Al-Salami
Bile acids play important roles in the human body, and changes in their pool can be used as markers for various liver pathologies. In addition to their functional effects in modulating inflammatory responses and cellular survivability, the unconjugated or conjugated, secondary, or primary nature of bile acids accounts for their various ligand effects. The common hydrophilic bile acids have been used
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Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma Curr. Drug Targets (IF 3.2) Pub Date : 2023-12-28 Junhui Wu, Jing Wei, Haoliang Chen, Yalong Dang, Fang Lei
Glaucoma is the most common cause of irreversible blindness worldwide. It is characterized by progressive optic nerve degeneration and loss of visual field. Pathological increased intraocular pressure is its main modifiable risk factor. Rho kinase inhibitors are developed as a new class of glaucoma medication that increases outflow facility from the conventional aqueous humor outflow pathway. Additionally
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ClpP Peptidase as a Plausible Target for the Discovery of Novel Antibiotics Curr. Drug Targets (IF 3.2) Pub Date : 2023-12-27 Smriti Bhardwaj, Kuldeep K. Roy
Antimicrobial resistance (AMR) to currently available antibiotics/drugs is a global threat. It is desirable to develop new drugs that work through a novel target(s) to avoid drug resistance. This review discusses the potential of the caseinolytic protease P (ClpP) peptidase complex as a novel target for finding novel antibiotics, emphasising the ClpP’s structure and function. ClpP contributes to the
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Breaking Barriers: Current Advances and Future Directions in Mpox Therapy Curr. Drug Targets (IF 3.2) Pub Date : 2023-12-27 Bhumi M. Shah, Palmi Modi
Background: Mpox, a newly discovered zoonotic infection, can be transmitted from animal to human and between humans. Serological and genomic studies are used to identify the virus. Objective: Currently, there are no proven effective treatments for Mpox. Also, the safety and efficacy of intravenous vaccinia immune globulin, oral Tecovirimat (an inhibitor of intracellular viral release), and oral Brincidofovir
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Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials Curr. Drug Targets (IF 3.2) Pub Date : 2023-12-21 Mohammad Ali Goudarzi, Zahra Sohrabi, Mohammad Hashem Hashempur, Saeed Nosratabadi, Zahra Namkhah, Cain C.T. Clark, Neda Haghighat
Introduction: There is a growing interest in the considerable benefits of grape products intake, as some studies have indicated that they may improve cardiometabolic risk factors. However, the widespread impact of grape products on the anthropometric indices is not fully resolved. Method: The purpose of this systematic review and meta-analysis was to examine the effects of grape products intake on
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Tebentafusp as a Promising Drug for the Treatment of Uveal Melanoma Curr. Drug Targets (IF 3.2) Pub Date : 2023-12-19 Khalid Al Balushi, Abdulrahman Al Hadhrami, Hamdan Al Balushi, Abdullah Al Lawati, Srijit Das
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and commonly occurs in the Caucasian population. The malignancy involves the uvea of the eye, which includes the iris, ciliary body, and choroid. The etiology of UM is still not well understood, but age is a risk factor. Symptoms include blurred vision, redness of the eye, floaters, dark spots, a change in the size of the
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An Exploratory Review on the Hypoglycemic Action of Unani Antidiabetic Drugs via Possible Modulation of Gut Microbiota Curr. Drug Targets (IF 3.2) Pub Date : 2023-12-19 Shaheen Akhlaq, Shabnam Anjum Ara, Malik Itrat, Mohammad Fazil, Bilal Ahmad, Usama Akram, Merajul Haque, Neelam Quddusi, Ahmad Sayeed
Background and Aim: Diabetes mellitus is a chronic, multi-factorial metabolic disorder and also an important public health issue that requires multi-dimensional therapeutic strategies for effective control. Unani herbs have long been used to effectively mitigate diabetes through various mechanisms. In recent years, it has been speculated that the alteration of gut microbiome ecology is potentially
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Transcription Factors in Brain Regeneration: A Potential Novel Therapeutic Target Curr. Drug Targets (IF 3.2) Pub Date : 2023-12-14 Basheer Abdullah Marzoog
Transcription factors play a crucial role in providing identity to each cell population. To maintain cell identity, it is essential to balance the expression of activator and inhibitor transcription factors. Cell plasticity and reprogramming offer great potential for future therapeutic applications, as they can regenerate damaged tissue. Specific niche factors can modify gene expression and differentiate
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An Update on the Emerging Role of Wnt/β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis Curr. Drug Targets (IF 3.2) Pub Date : 2023-12-11 Pradyuman Prajapati, Gaurav Doshi
Rheumatoid arthritis is an untreatable autoimmune disorder. The disease is accompanied by joint impairment and anomalies, which negatively affect the patient’s quality of life and contribute to a decline in manpower. To diagnose and treat rheumatoid arthritis, it is crucial to understand the abnormal signaling pathways that contribute to the disease. This understanding will help develop new rheumatoid
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Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer Curr. Drug Targets (IF 3.2) Pub Date : 2023-12-06 Bhavna Yadav, Mahima Chauhan, Rahul Pratap Singh, Sonali, Saurabh Shekhar
Lung cancer is one of the leading causes of death across the world. There are numerous challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive. Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research areas. It has the
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Therapeutic Potential of Targeting Transforming Growth Factor-beta (TGF-β) and Programmed Death-ligand 1 (PD-L1) in Pancreatic Cancer Curr. Drug Targets (IF 3.2) Pub Date : 2023-12-05 Ghazaleh Pourali, Nima Zafari, Mahla Velayati, Shima Mehrabadi, Mina Maftooh, Seyed Mahdi Hassanian, Majid Ghayour Mobarhan, Gordon A. Ferns, Amir Avan, Majid Khazaei
Pancreatic cancer (PC) is one the most lethal malignancies worldwide affecting around half a million individuals each year. The treatment of PC is relatively difficult due to the difficulty in making an early diagnosis. Transforming growth factor-beta (TGF-β) is a multifunctional factor acting as both a tumor promoter in early cancer stages and a tumor suppressor in advanced disease. Programmed death-ligand
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Deciphering the Function of New Therapeutic Targets and Prospective Biomarkers in the Management of Psoriasis Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-30 Japneet Singh Purewal, Gaurav Mahesh Doshi
Psoriasis is an immune-mediated skin condition affecting people worldwide, presenting at any age, and leading to a substantial burden physically and mentally. The innate and adaptive immune systems interact intricately with the pathomechanisms that underlie disease. T cells can interact with keratinocytes, macrophages, and dendritic cells through the cytokines they secrete. According to recent research
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Novel Targets and Drug Delivery System in the Treatment of Postoperative Pain: Recent Studies and Clinical Advancement Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-30 Trilochan Satapathy, Gulab Singh, Ravindra Kumar Pandey, Shiv Shankar Shukla, Shiv Kumar Bhardwaj, Beena Gidwani
Pain is generated by a small number of peripheral targets. These can be made more sensitive by inflammatory mediators. The number of opioids prescribed to the patients can be reduced dramatically with better pain management. Any therapy that safely and reliably provides extended analgesia and is flexible enough to facilitate a diverse array of release profiles would be useful for improving patient
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Flavonoids as G Protein-coupled Receptors Ligands: New Potential Therapeutic Natural Drugs Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-30 Alae Chda, Rachid Bencheikh
G protein coupled receptors (GPCRs) are among the largest family of cell surface receptors found in the human genome. They govern a wide range of physiological responses in both health and diseases, making them one of the potential targeted surface receptors for pharmaceuticals. Flavonoids can modulate GPCRs activity by acting as allosteric ligands. They can either enhance or reduce the GPCR's effect
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The Development of the Combination Drug Leukovir® Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-30 Elena N. Kalinichenko, Svetlana V. Babitskaya
The review is devoted to the development and study of the drug Leukovir® (cladribine+ ribavirin) and its use in the treatment of relapsing-remitting and secondary progressive forms of multiple sclerosis, a chronic neurodegenerative disease aiming the risk reduction of relapse and progression of a disability. In clinical trials Leukovir® has proved to be efficient by up to 56 weeks for the treatment
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Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-29 Poonam Patil, Gaurav Doshi
: Pyroptosis has become a noteworthy area of focus in recent years due to its association with inflammatory diseases. Pyroptosis is a type of programmed cell death accompanied by an inflammatory response, and the discovery of the gasdermin family has expanded the study of pyroptosis. The primary characteristics of pyroptosis include cell expansion, membrane penetration, and the ejection of cell contents
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Biomarkers and Treatment Strategies for Breast Cancer Recurrence Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-29 Shivam Rajput, Pramod Kumar Sharma, Rishabha Malviya
: Despite recent treatment advancements, breast cancer remains a life-threatening disease. Although treatment is successful in the early stages, a significant proportion of individuals with breast cancer eventually experience a recurrence of the disease. Breast tumour recurrence poses a significant medical issue. Despite tumours being a primary cause of mortality, there remains a limited understanding
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Antiviral Potential of Traditional Unani Medicine with Special Emphasis on Dengue: A Review Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-21 Muzayyana Khan, Mohammad Altamish, Monalisha Samal, Varsha Srivastav, Areeba Insaf, Rabea Parveen, Jamal Akhtar, Anuja Krishnan, Sayeed Ahmad
Dengue fever has become a major public health concern. It is usually related to intravascular leaking, bleeding disorders, and thrombocytopenia and is recognized as a potent threat to humans. The scarcity of anti-dengue medication or vaccine for such a serious disease leads to an upsurge in the usage of traditional medicines for its proper management. India has diverse biodiversity and a long history
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Targeted Delivery Strategies of Herbal-Based Nanogels: Advancements and Applications Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-10 Sudhanshu Mishra, Sonali Jayronia, Lalit Kumar Tyagi, Kanchan Kohli
The objective of this review is to thoroughly investigate herbal nano gels as a promising drug delivery approach for the management of various chronic and acute disorders. Herbal nano gels are a novel and promising drug delivery technique, offering special benefits for better therapeutic efficacy. This review offers a comprehensive analysis of the herbal nano gels with a particular emphasis on their
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Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-09 Abdullah, Mir Azam Khan, Achyut Adhikari
Introduction: Rosa webbiana (RW) Wall Ex. Royle is used in traditional medicine in Pakistan for the treatment of several diseases including jaundice. To date, only neuroprotective potential of the plant has been evaluated. Objective: The current study was designed to isolate bioactive compound(s) and investigate its possible radical scavenging, anti-inflammatory and hepatoprotective activities. Methods:
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Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-09 Harish Bhardwaj, Sulekha Khute, Ram Sahu, Rajendra Kumar Jangde
The diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing
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NLRP3: A Promising Therapeutic Target for Inflammatory Bowel Disease Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-08 Jiayu Zhang, Shuyan Zeng, Peng Wang, Youxiang Chen, Chunyan Zeng
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is an intestinal disease with complicated pathological mechanisms. The incidence of IBD has been increasing in recent years, which has a significant negative impact on the lives of patients. Therefore, it is particularly important to find new therapeutic targets and innovative drugs for the development of IBD.
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N-Heterocycle based Degraders (PROTACs) Manifesting Anticancer Efficacy: Recent Advances Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-08 Suddhasatwa Banerjee, Sachin Sharma, Amandeep Thakur, Ritika Sachdeva, Ram Sharma, Kunal Nepali, Jing Ping Liou
Proteolysis Targeting Chimeras (PROTACs) technology has emerged as a promising strategy for the treatment of undruggable therapeutic targets. Researchers have invested a great effort in developing druggable PROTACs; however, the problems associated with PROTACs, including poor solubility, metabolic stability, cell permeability, and pharmacokinetic profile, restrict their clinical utility. Thus, there
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Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-07 Xiaoli Zhang, Yalei Zhao, Liangru Liu, Yingli He
Syndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the
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Crucial Role of microRNAs as New Targets for Amelogenesis Disorders Detection Curr. Drug Targets (IF 3.2) Pub Date : 2023-11-05 Nadezhda Masunova, Maria Tereschenko, Georgy Alexandrov, Liudmila Spirina, Natalia Tarasenko
Introduction: Amelogenesis imperfecta (AI) refers to a heterogeneous group of conditions with multiple factors which contribute to the hypomineralisation of enamel. Preventive measures are necessary to predict this pathology. Prospects for preventive medicine are closely related to the search for new informative methods for diagnosing a human disease. MicroRNAs are prominent for the non-invasive diagnostic
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Targeting Lysyl Oxidase as a Potential Therapeutic Approach to Reducing Fibrotic Scars Post-operatively: Its Biological Role in Post-Surgical Scar Development Curr. Drug Targets (IF 3.2) Pub Date : 2023-10-27 Mahin Ghorban Sabbagh, Mohsen Aliakbarian, Rozita Khodashahi, Gordon-A Ferns, Hoda Rahimi, Kiarash Ashrafzadeh, Mahmoud Tavakkoli, Mohammad-Hassan Arjmand
Abdominal and pelvic surgery, or any surgical injury of the peritoneum, often leads to chronic abdominal adhesions that may lead to bowel obstruction, infertility, and pain. Current therapeutic strategies are usually ineffective, and the pathological mechanisms of the disease are unclear. Excess collagen cross-linking is a key mediator for extra-cellular matrix deposition and fibrogenesis. Lysyl oxidase
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An Insight into Hepatitis C Virus: In Search of Promising Drug Targets Curr. Drug Targets (IF 3.2) Pub Date : 2023-10-27 Manish Dwivedi, Aditya Dwivedi, Debalina Mukherjee
Hepatitis C Virus (HCV) is a global health concern, chronically infecting over 70 million people worldwide. HCV is a bloodborne pathogen that primarily affects the liver, and chronic HCV infection can lead to cirrhosis, liver cancer, and liver failure over time. There is an urgent need for more effective approaches to prevent and treat HCV. This review summarizes current knowledge on the virology,
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The (Pro)renin Receptor - A Regulatory Nodal Point in Disease Networks Curr. Drug Targets (IF 3.2) Pub Date : 2023-10-25 Heiko Funke-Kaiser, Thomas Unger
Experimental inhibition of the (pro)renin receptor [(P)RR] is a promising therapeutic strategy in different disease models ranging from cardiorenal to oncological entities. Here, we briefly review the direct protein-protein interaction partners of the (P)RR and the plethora of distinct diseases in which the (P)RR is involved. The first structural work on the (P)RR using AlphaFold, which was recently
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SGK-1 Signalling Pathway is a Key Factor in Cell Survival in Ischemic Injury Curr. Drug Targets (IF 3.2) Pub Date : 2023-10-22 Manisha Chaudhary, Veerta Sharma, Onkar Bedi, Amarjot Kaur, Thakur Gurjeet Singh
Serum and glucocorticoid-regulated kinases (SGK) are serine/threonine kinases that belong to AGC. The SGK-1, which responds to stress, controls a range of ion channels, cell growth, transcription factors, membrane transporters, cellular enzymes, cell survival, proliferation and death. Its expression is highly controlled by various factors such as hyperosmotic or isotonic oxidative stress, cell shrinkage
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The Surging Mechanistic Role of Angiotensin Converting Enzyme 2 in Human Pathologies: A Potential Approach for Herbal Therapeutics Curr. Drug Targets (IF 3.2) Pub Date : 2023-10-19 Priyadarshini Gupta, Vibha Rani
: Advancements in biological sciences revealed the significant role of angiotensin-converting enzyme 2 (ACE2), a key cell surface receptor in various human pathologies. ACE2 is a metalloproteinase that not only functions in the regulation of Angiotensin II but also possesses some non-catalytic roles in the human body. There is considerable uncertainty regarding its protein expression, despite its presence
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Viaminate Inhibits Propionibacterium Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade Curr. Drug Targets (IF 3.2) Pub Date : 2023-10-19 Junjie Cao, Meifeng Xu, Longfei Zhu, Shengxiang Xiao
Background: Viaminate, a vitamin A acid drug developed in China, has been clinically used in acne treatment to regulate epithelial cell differentiation and proliferation, inhibit keratinization, reduce sebum secretion, and control immunological and anti-inflammatory actions; however, the exact method by which it works is unknown. Methods: In the present study, acne was induced in the ears of rats using
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BRD4 Protein as a Target for Lung Cancer and Hematological Cancer Therapy: A Review Curr. Drug Targets (IF 3.2) Pub Date : 2023-10-16 Mengmeng Zhang, Yingbo Li, Zilong Zhang, Xin Zhang, Wei Wang, Xiaomei Song, Dongdong Zhang
The BET protein family plays a crucial role in regulating the epigenetic landscape of the genome. Their role in regulating tumor-related gene expression and its impact on the survival of tumor cells is widely acknowledged. Among the BET family constituents, BRD4 is a significant protein. It is a bromodomain-containing protein located at the outer terminal that recognizes histones that have undergone
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Recent Advances in the Prevention and Management of Monkeypox Viral Infection in Humans Curr. Drug Targets (IF 3.2) Pub Date : 2023-10-16 Preeti Gujjar, Rishabh Chaudhay, Inderjeet Verma, Nitin Bansal, Sumeet Gupta, Seema Bansal
Background: There have been several neglected infectious pathogens that have reemerged in the last few decades, including the monkeypox virus, a virus from the orthopoxviral genus that causes monkeypox and is transmitted between animals and humans. The human monkeypox outbreak has spread to several different countries. Because of the outbreak's unusually high case count and lack of connections to endemic
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Review on the Drug Intolerance and Vaccine Development for the Leishmaniasis Curr. Drug Targets (IF 3.2) Pub Date : 2023-10-04 Priya Kumari, Afrin Mamud, Anupam Nath Jha
Leishmaniasis is one of the Neglected Tropical Diseases (NTDs), a zoonotic disease of vector-borne nature that is caused by a protozoan parasite Leishmania. This parasite is transmitted by the vector sandfly into the human via a bite. Visceral leishmaniasis (VL), also called kala-azar, is the most fatal among the types of leishmaniasis, with high mortality mostly spread in the East Africa and South
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Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis Curr. Drug Targets (IF 3.2) Pub Date : 2023-09-22 Malkiet Kaur, Manju Nagpal, Amarjot Kaur Grewal, Samrat Chauhan, Chander Parkash Dora, Thakur Gurjeet Singh
Background: Statins, especially simvastatin promote bone formation by stimulating the activity of osteoblasts and suppressing osteoclast activity via the BMP-Smad signaling pathway. Statins present the liver first-pass metabolism. This study attempts to fabricate and evaluate simvastatin functionalized hydroxyapatite encapsulated in poly(lactic-co-glycolic) acid (PLGA) nanoparticles (HSIM-PLGA NPs)
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Inhibitors of Stimulator of Interferon Genes from 2019 to July 2022: An Overview of the Structure and Bioactivity Curr. Drug Targets (IF 3.2) Pub Date : 2023-09-12 Feng Xu, Xinjian Tian, Qiangsheng Zhu, Ziwen Feng, Hui Li, Wei Dai, Yeling Zhou, Qi-Dong You, Xiaoli Xu
Stimulator of interferon genes (STING) plays a vital role in the human innate immune system. Aberrant expression of STING has been proven to be associated with several diseases, such as STING-associated vasculopathy with onset in infancy, Aicardi-Goutieres syndrome, and system-ic lupus erythematosus. Therefore, inhibition of the STING signaling pathway can also be expected to provide effective therapeutic
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Extracellular Vesicles from Stromal Vascular Fraction of Human Adipose Tissue in the Development of Non-antibiotic Therapy Curr. Drug Targets (IF 3.2) Pub Date : 2023-09-11 V.M.H. Srinivasa, B.M. Kumar, Prakash Patil, Nikhil Shetty, A.V. Shetty
Background: Antibiotic-resistant microorganisms (ARMS) are the leading cause of socio- economic loss in the world, with historical evidence linking them to increased mortality and morbidity. Methodology:In this systematic review, we highlight a new treatment approach for antibiotic-resistant infections using 'Extracellular vesicle (EVs)-based therapy,' also known as cell- and drug-free therapy. Here
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Sodium-glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy Curr. Drug Targets (IF 3.2) Pub Date : 2023-09-08 Zhicheng Gao, Jiaqi Bao, Yilan Hu, Junjie Tu, Lifang Ye, Lihong Wang
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new type of oral hypoglycemic drugs that exert a hypoglycemic effect by blocking the reabsorption of glucose in the proximal renal tubules, thus promoting the excretion of glucose from urine. Their hypoglycemic effect is not dependent on insulin. Increasing data shows that SGLT2 inhibitors improve cardiovascular outcomes in patients with type
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A Comprehensive Review on Therapeutic Potential of a Natural Anthraquinone Derivative Emodin in Brain-related Disorders Curr. Drug Targets (IF 3.2) Pub Date : 2023-08-31 Ahsas Goyal, Yogesh Murti, Bharat Bhushan, Wasim Chisti, Ashutosh Solanki
Brain-related disorders are one of the world’s most important and complex health problems today. These brain-related disorders are responsible for a massive number of morbidities and death all around the world. However, researchers have devoted a large amount of time to investigating these diseases and found positive results; nevertheless, there are currently quite a few medications available to treat
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Bio-Functional Mesoporous Silica Nanoparticles as Nano-Structured Carriers in Cancer Theranostic Review on Recent Advancements Curr. Drug Targets (IF 3.2) Pub Date : 2023-08-25 Darshan Gevariya, Lipika Priya, Smit Mehta, Vishwas Patel, Dhara Bhuva, Drishti Panjwani, Shruti Patel, Priyanka Ahlawat, Abhay Dharamsi, Asha Patel
Background: Cancer is a life-threatening disease worldwide, but proper treatment has not yet been developed. Many therapies are available to treat cancer disorders, like chemotherapy, surgery, hormone therapy, and immunotherapy. Chemotherapy often relies on a combination of harmful, highly toxic platinum-based compounds. Also, there are chances of poor distribution of chemotherapeutic agents and cytotoxic
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Estimating the Survival Rate in Glioblastoma Multiforme Patients who Received a Peptide Vaccine: A Systematic Review and Meta-analysis Curr. Drug Targets (IF 3.2) Pub Date : 2023-08-25 Masoumeh Eliyasi Dashtaki, Zahra Moradi, Yousef Moradi, Elham Asadi Farsani, Sorayya Ghasemi
Introduction: Glioblastoma Multiforme (GBM) has a poor prognosis, with current treatments providing no advantage in terms of survival. Certain new immunotherapy methods, such as peptide vaccines, have been used in clinical trials. In this meta-analysis, the effectiveness of peptide vaccinations on the survival rate of GBM patients was studied. Methods: A comprehensive search was carried out using three
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Microtubules and Cell Division: Potential Pharmacological Targets in Cancer Therapy Curr. Drug Targets (IF 3.2) Pub Date : 2023-08-07 Jomon Sebastian, Krishnan Rathinasamy
Microtubules are a well-known target in cancer chemotherapy because of their critical role in cell division. Chromosome segregation during mitosis depends on the establishment of the mitotic spindle apparatus through microtubule dynamics. The disruption of microtubule dynamics through the stabilization or destabilization of microtubules results in the mitotic arrest of the cells. Microtubule-targeted
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Cytotoxic Flavokawain B Inhibits the Growth and Metastasis of Hepatocellular Carcinoma through UCK2 Modulation of the STAT3/Hif-1α/VEGF Signalling Pathway Curr. Drug Targets (IF 3.2) Pub Date : 2023-08-04 Ibrahim Malami, Alhassan Alhassan, Adamu Adamu, Muhammad Bello, Aliyu Muhammad, Mustapha Imam
Background: Hepatocellular carcinoma (HCC) is associated with a high mortality rate due to early recurrence and its metastasis features. To this day, effective treatment options for metastatic HCC remain a major challenge to patient treatment. Flavokawain B (FKB) is a naturally occurring chalcone molecule capable of providing effective therapy against this life-threatening disease. Objective: This
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Therapeutic Potential of Plant Metabolites in Bone Apoptosis: A Review Curr. Drug Targets (IF 3.2) Pub Date : 2023-08-04 Kadirvel Devi, Thukani Sathanantham Shanmugarajan
Osteoporosis is one of the skeletal diseases of major health concern worldwide. Homeostasis of bone occurs with the help of cells, namely, osteoblasts and osteoclasts. Physiological and pathological conditions involve the death of the cells by apoptosis, autophagy, and necrosis. Apoptosis is a key factor in the growth, development, and maintenance of the skeleton. Apoptosis is generated by two pathways:
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Co-Crystallization: A Novel Technique to Improvise the Pharmaceutical Characteristics of API’s Curr. Drug Targets (IF 3.2) Pub Date : 2023-08-04 Aditay Kumar, Mahesh Kumar
Background: The poor water solubility of an active pharmaceutical ingredient leads to a lower dissolution profile that in turn results in poor bioavailability of drugs. Various approaches like solid dispersion, nano-technology, complexation, and micronization techniques, etc. are frequently used by pharmaceutical researchers to overcome these issues. In this context, crystal engineering emerges as
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Current Prospects of Saponins as Promising Anti-Trypanosoma brucei Compounds: Insight into the Mechanisms of Action Curr. Drug Targets (IF 3.2) Pub Date : 2023-07-27 Boniface Pone Kamdem, Fabrice Fekam Boyom
Background: Human African trypanosomiasis (HAT) is a parasitic infection that may lead to death if left untreated. This disease is caused by a protozoan parasite of the genus Trypanosoma and is transmitted to humans through tsetse fly bites. The disease is widespread across Sub- -Saharan Africa, with 70% of cases in recent reports in the Democratic Republic of the Congo and an average of less than
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Targets Involved in Skin Aging and Photoaging and their Possible Inhibitors: A Mini-review Curr. Drug Targets (IF 3.2) Pub Date : 2023-07-27 Jéssica Paiva de Moura, Érika Paiva de Moura Fernandes, Teresa Carolliny Moreira Lustoza Rodrigues, Alex France Messias Monteiro, Natália Ferreira de Sousa, Aline Matilde Ferreira dos Santos, Marcus Tullius Scotti, Luciana Scotti
Background: Skin aging is a natural process resulting from intrinsic (hormonal and genetic) and extrinsic (environmental) factors. Photoaging occurs due to prolonged exposure of the skin to ultraviolet radiation, accounting for 80% of facial aging. Introduction: Characteristics of aging skin include reduced elasticity, the appearance of fine wrinkles, uneven tone, and dryness. Clinical signs of photoaging