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Epidemiology and risk factors of bloodstream infections among adolescents and young adults with acute lymphoblastic leukaemia: An 11‐year retrospective cohort study Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-03-07 Longlong Xue, Yishu Tang, Liwen Wang, Cong Xu, Qian Cheng, Xin Li
Adolescent and young adults (AYAs) belong to a unique category of patients diagnosed with acute lymphoblastic leukaemia (ALL). Bloodstream infection (BSI) is a leading cause of treatment‐related mortality in ALL patients. However, the epidemiology and risk factors for mortality from BSIs in AYA patients remain unclear. In this study, we analysed these aspects in AYAs patients and compared similarities
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A 2‐week treatment with 5‐azacytidine improved the hypercontractility state in prostate from obese mice: Role of the nitric oxide‐cyclic guanosine monophosphate signalling pathway Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-03-07 Ana Carolina Ghezzi, Gabriela Reolon Passos, Mariana Gonçalves de Oliveira, Akila Lara Oliveira, Guilherme Rossi Assis‐Mendonça, Glaucia Coelho de Mello, Edson Antunes, Fabiola Zakia Monica
Benign prostatic hyperplasia (BPH) is characterised by increases in prostate volume and contraction. Downregulation of the nitric oxide (NO)‐cyclic guanosine monophosphate (cGMP) signalling pathway contributes to prostate dysfunctions. Previous studies in cancer cells or vessels have shown that the epigenetic mechanisms control the gene and protein expression of the enzymes involved in the production
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Differential responses of cerebral and renal oxygenation to altered perfusion conditions during experimental cardiopulmonary bypass in sheep Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-03-07 Roger G. Evans, Andrew D. Cochrane, Sally G. Hood, Bruno Marino, Naoya Iguchi, Rinaldo Bellomo, Peter R. McCall, Nobuki Okazaki, Alemayehu H. Jufar, Lachlan F. Miles, Taku Furukawa, Connie P. C. Ow, Jaishankar Raman, Clive N. May, Yugeesh R. Lankadeva
We tested whether the brain and kidney respond differently to cardiopulmonary bypass (CPB) and to changes in perfusion conditions during CPB. Therefore, in ovine CPB, we assessed regional cerebral oxygen saturation (rSO2) by near‐infrared spectroscopy and renal cortical and medullary tissue oxygen tension (PO2), and, in some protocols, brain tissue PO2, by phosphorescence lifetime oximetry. During
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Study on the mechanism underlying Trichosanthis peel injection‐induced improvements in myocardial fibrosis markers in patients with chronic heart failure Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-02-29 Yue He, Xinsheng Gu, Zhou Yang, Hao Wang, Ping Liu
In this research, we aimed to observe the changes in myocardial fibrosis indices in patients with chronic heart failure before and after treatment and to evaluate the anti‐chronic heart failure and ventricular remodelling effects of Trichosanthis peel (TP) injection. This study was a single‐center, open, single‐blind, randomized controlled study with an optimal efficacy design. Patients were consecutively
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Phosphatidylserine accelerates wound healing and reduces necrosis in the rats: Growth factor activation Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-02-27 Partow Mirzaee Saffari, Pooria Asili, Sadaf Eshraghi, Ahad Muhammadnejad, Ahmad Reza Dehpour, Ramin Goudarzi, Alireza Partoazar
To examine the effect of topical phosphatidylserine (PS) on wound healing factors and tissue necrosis in in vivo models. Topical PS was applied to evaluate aspects of the wound healing process and growth factors production of vascular endothelial growth factors (VEGF) as well a necrosis reduction in the skin flap of rat models. Moreover, phenytoin (PHT) and cyclosporine A (CsA) were used topically
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Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-02-21 Wen‐Cong Gao, Tie‐Hua Yang, Bin‐Bao Wang, Qian Liu, Qing Li, Xiao‐Huan Zhou, Chang‐Bo Zheng, Peng Chen
Abnormalities in vascular smooth muscle cells (VSMCs) are pivotal in the pathogenesis of cardiovascular pathologies such as atherosclerosis and hypertension. Scutellarin (Scu), a flavonoid derived from marigold flowers, exhibits a spectrum of biological activities including anti‐inflammatory, antioxidant, antitumor, immunomodulatory and antimicrobial effects. Notably, Scu has demonstrated the capacity
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Gaillardin exerts potent antileukemic effects on HL‐60 cells and intensifies arsenic trioxide cytotoxicity: Providing new insight into sesquiterpene lactones in leukaemia treatment Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-02-21 Hanieh Noormohamadi, Maryam Hamzeloo‐Moghadam, Davood Bashash, Maryam Kargar, Mehrdad Izadirad, Seyedeh Zahra Hasanpour, Ahmad Gharehbaghian
The use of all‐trans retinoic acid and arsenic trioxide resulted in favourable therapeutic responses in standard‐risk acute promyelocytic leukaemia (APL) patients. However, resistance to these agents has made treating the high‐risk subgroup more problematic, and possible side effects limit their clinical dosages. Numerous studies have proven the cytotoxic properties of Gaillardin, one of the Inula
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Dapagliflozin alleviates high glucose‐induced injury of endothelial cells via inducing autophagy Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-02-21 Gen Li, Ningxin Hou, Huagang Liu, Jun Li, Hongping Deng, Hongwen Lan, Sizheng Xiong
Hyperglycaemia is a key factor in the progression of diabetes complications. Dapagliflozin (DAPA), a new type of hypoglycaemic agent, has been shown to play an important role in anti‐apoptotic, anti‐inflammatory and antioxidant activities. Previous studies have demonstrated an endothelial protective effect of DAPA, but the underlying mechanism was still unclear. Autophagy is a homeostatic cellular
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Synergic actions of botulinum neurotoxin A and oxaliplatin on colorectal tumour cell death through the upregulation of TRPM2 channel-mediated oxidative stress Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-02-13 Sıdıka Demir, İpek Duman, Mustafa Nazıroğlu
Botulinum neurotoxin A (BoNT) is being shown to have anticancer action as a potential adjuvant treatment. The transient receptor potential (TRP) melastatin 2 (TRPM2) stimulator action of BoNT was reported in glioblastoma cells, but not in colorectal cancer (HT29) cells. By activating TRPM2, we evaluated the impacts of BoNT and oxaliplatin (OXA) incubations on oxidant and apoptotic values within the
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Empagliflozin attenuates liver fibrosis in high-fat diet/streptozotocin-induced mice by modulating gut microbiota Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-01-28 Chuxin Huang, Jiali Qian, Ying Liu, Li Zhang, Yehong Yang
The effects of SGLT2 inhibitors on hepatic fibrosis in diabetes remain unclear. This study aimed to investigate the effects of empagliflozin on liver fibrosis in high-fat diet/streptozotocin-induced mice and the correlation with gut microbiota. After the application of empagliflozin for 6 weeks, we performed oral glucose tolerance and intraperitoneal insulin tolerance tests to assess glucose tolerance
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Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-01-28 Shan Zeng, Yeying Wang, Li Ai, Liwei Huang, Zhijuan Liu, Chunxia He, Qiaohui Bai, Yongxia Li
This study explores the potential mechanisms of obstructive sleep apnoea (OSA) complicates type 2 diabetes mellitus (T2DM) by which chronic intermittent hypoxia (CIH) induces insulin resistance and cell apoptosis in the pancreas through oxidative stress. Four- and eight-week CIH rat models were established, and Tempol (100 mg/kg/d), was used as an oxidative stress inhibitor. This study included five
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Metabolomic modelling and neuroprotective effects of carvacrol against acrylamide toxicity in rat's brain and sciatic nerve Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-01-20 Hatipoglu Durmus, Ates M. Burak, Senturk Goktug, Bulut Aysegul
The study aimed to investigate the harmful effects of acrylamide (AA), which forms in carbohydrate-rich foods at temperatures above 120°C, on the central and peripheral nervous systems and to evaluate the potential neuroprotective effects of carvacrol (CRV). Male Wistar Albino rats were subjected to AA (40 mg/kg/bw/day) and CRV (50 mg/kg/bw/day) for 15 days. Following the last administration, evaluations
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Adrenalectomy attenuates hyperalgesia but does not regulate muscle wasting in a female rat model of fibromyalgia Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-01-10 Daniely Messias Costa, Raquel Prado da Silva, João da Cruz-Filho, Tatiane de Oliveira Santos, Hevely Catharine dos Anjos-Santos, Waldecy de Lucca Jr, Ísis do Carmo Kettelhut, Luiz Carlos Navegantes, Patrícia Rodrigues Marques de Souza, Enilton Aparecido Camargo, Sandra Lauton-Santos, Daniel Badauê-Passos Jr, André Souza Mecawi, Josimari Melo DeSantana, Danilo Lustrino
Although it is well established that fibromyalgia (FM) syndrome is characterized by chronic diffuse musculoskeletal hyperalgesia, very little is known about the effect of this pathology on muscle tissue plasticity. Therefore, the present study aimed to characterize the putative alterations in skeletal muscle mass in female rats subjected to a FM model by inducing chronic diffuse hyperalgesia (CDH)
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Correction to “Exosomal miR-21-5p derived from multiple myeloma cells promote renal epithelial–mesenchymal transition through targeting TGF-β/SMAD7 signalling pathway” Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-01-11
Liping Liu, Langni Liu, Rui Liu, Jing Liu, Qian Cheng, Clinical and Experimental Pharmacology and Physiology, First published: 11 March 2023. https://doi.org/10.1111/1440-1681.13768 In paragraph of the “Funding” and “Acknowledgment” section, the number of “Hunan Provincial Natural Science Foundation of China” was incorrect. The number should be 2021JJ40917, not 2021JJ40916. We apologize for this error
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SEW2871 reduces seizures via the sphingosine 1-phosphate receptor-1 pathway in the pentylenetetrazol and phenobarbitone kindling model of drug-refractory epilepsy Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-01-11 Ashish Jain, Arti Ralta, Gitika Batra, Rupa Joshi, Nitika Garg, Alka Bhatia, Bikash Medhi, Amitava Chakrabarti, Ajay Prakash
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Dihydromyricetin reverses capecitabine-induced peripheral myelin dysfunction through modulation of oxidative stress Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-01-09 Jie Fang, Shuyi Lou, Xinyi Zhou, Dayong Lou, Liqin Zhou, Rong Bian
Previous clinical reports have shown that capecitabine, an oral prodrug of 5-fluorouracil (5-Fu), can induce peripheral neuropathy, resulting in numbness, paresthesia and hypoesthesia. However, the mechanism through which capecitabine causes peripheral nerve injury remains unclear. Here, we demonstrate that systemic administration of capecitabine leads to myelin abnormalities in the peripheral nerves
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Effects of a single dose of rocuronium in patients with different body fat percentages: A randomised controlled trial Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-01-09 Guanghui An, Yan Qiu, Zheliang Zhou, Xueying Ding, Cheng Li
The pharmacodynamics in patients with high body fat percentage might be similar to those in obese patients. This randomised controlled clinical trial observed the effects of rocuronium in patients with different percent body fats (PBFs). Fifty-four patients who underwent elective urological or pelvic surgery under general anaesthesia at Shanghai General Hospital were included in the present study;
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Comparison of the negative effect of remimazolam and propofol on cardiac contractility: Analysis of a randomised parallel-group trial and a preclinical ex vivo study Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2024-01-09 Yusuke Yoshikawa, Shunsuke Oura, Masatoshi Kanda, Tomohiro Chaki, Naoyuki Hirata, Mitsutaka Edanaga, Michiaki Yamakage
Remimazolam is a newly developed ultra-short-acting benzodiazepine that exerts sedative effects. This study aimed to clarify the effects of remimazolam on cardiac contractility. In a randomised-parallel group trial, haemodynamic parameters were compared between propofol (n = 11) and remimazolam (n = 12) groups during the induction of general anaesthesia in patients undergoing non-cardiac surgery. In
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Tanshinone IIA ameliorates the development of dermal fibrosis in systemic sclerosis Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-11-30 Ying Jiang, Feifei Hu, Ming Li, Qiao Li
We previously revealed the role of tanshinone IIA (TAN IIA) on endothelial cells and the impact of TAN IIA on the endothelial-to-mesenchymal transition in systemic sclerosis (SSc). In this study, we sought to further determine whether TAN IIA can directly act on the skin fibroblasts of scleroderma and look into its underlying anti-fibrotic mechanisms.
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Improved cardioprotective effect of 3-nitro-N-methyl salicylamide solution after a prolonged preservation time of rat heart Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-11-23 Shuo Wang, Wenjun Liu, Shan Liu, Jiacong Li, Yi Geng, Yungang Zhao
Ischemic reperfusion injury, caused by oxidative stress during reperfusion, is an inevitable outcome of organ transplantation, especially when the organ preservation time is prolonged. Prolonged ischaemic preservation is a valuable technique for improving the success of organ transplantation, but numerous challenges remain. 3-nitro-N-methyl salicylamide (3-NNMS), an inhibitor of mitochondrial electron
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Agomelatine alleviates steroid-induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-11-11 Samaa M. El-Mahroky, Mahitab M. Nageeb, Dalia A. Hemead, Enas G. Abd Allah
One of the major contributors to secondary osteoporosis is long-term glucocorticoid usage. Clinically used antidepressant agomelatine also has anti-inflammatory properties. Our research aimed to inspect the probable defensive effect of agomelatine against steroid-promoted osteoporosis. There were four groups of rats; group I had saline as a negative control; rats of group II had dexamethasone (0.6 mg/kg
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IL-4/STAT6 axis observed to reverse proliferative defect in SCA3 patient-derived neural progenitor cells Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-11-07 Francis M. Chen, Huixian Li, Dittman Lai-Shun Chung, Angel T. L. Mak, Fung Ping Leung, Ho Yin Edwin Chan, Wing Tak Wong
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Correction to “Ginsenoside 20(S)-Rg3 upregulates HIF-1α-targeting miR-519a-5p to inhibit the Warburg effect in ovarian cancer cells” Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-11-02
Lu J, Chen H, He F, et al. Ginsenoside 20(S)-Rg3 upregulates HIF-1α-targeting miR-519a-5p to inhibit the Warburg effect in ovarian cancer cells. Clin Exp Pharmacol Physiol. 2020;47(8):1455-1463. The Western blot image of β-actin in the right panel of Figure 4A had been misplaced by the Western blot image of β-actin in the right panel of Figure 7A during figure assembly. The correct version of Figure
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Pharmacogenomics and adverse effects of anti-infective drugs in children Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-10-15 Xin Huang, Biwen Hu, Ling Ye, Tong Li, Li He, Wei Tan, Guoping Yang, Jun-Ping Liu, Chengxian Guo
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Application of 3D computed tomography in emphysematous parenchyma patients scheduled for bronchoscopic lung volume reduction Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-10-08 Ping Wei, Ru-Jia Tao, Hai-wen Lu, Jin-Fu Xu, Yi-han Liu, Hai Wang, Ling-Ling Li, Ye Gu, Wei-Jun Cao
Bronchoscopic lung volume reduction (BLVR) is a feasible, safe, effective and minimally invasive technique to significantly improve the quality of life of advanced severe chronic obstructive pulmonary disease (COPD). In this study, three-dimensional computed tomography (3D-CT) automatic analysis software combined with pulmonary function test (PFT) was used to retrospectively evaluate the postoperative
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Circ_0026579 knockdown ameliorates lipopolysaccharide-induced human lung fibroblast cell injury by regulating CXCR1 via miR-370-3p Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-10-02 Yuanhong Zhuang, Yuyun Yang, Lihong Peng
Pneumonia is an inflammatory disease in lower respiratory tracts and its development involves the regulation of RNAs. Circular RNAs are a class of RNA subgroups that can mediate the progression of pneumonia. However, the molecular mechanism of circ_0026579 in regulating pneumonia occurrence remains unclear. The study is designed to reveal the role of circ_0026579 in lipopolysaccharide (LPS)-induced
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Monocarboxylate transporter 4 protects against myocardial ischemia/reperfusion injury by inducing oxidative phosphorylation/glycolysis interconversion and inhibiting oxidative stress Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-09-28 Qiao Pan, Xiaobo Xie, Qingxia Yuan
Myocardial ischemia/reperfusion (I/R) injury is the primary cause of heart damage in the treatment of myocardial infarction, and the imbalance of the energy metabolism in the pathogenesis of myocardial I/R is one of the main triggers of cardiac dysfunction. Monocarboxylate transporter 4 (MCT4) is a key transporter of lactate, which plays a vital role in cellular metabolism. The present study investigated
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Pharmacodynamic study of chitosan in combination with salvianolic acid B in the treatment of CC14-induced liver fibrosis in mice Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-09-25 Zhongwei Yao, Minshu Du, Yalu Wang, He Zhu, Luan Shu, Xia You, Jing Wang
Liver fibrosis is a chronic liver lesion caused by excessive deposition of the extracellular matrix after liver damage, resulting in fibrous scarring of liver tissue. The progression of liver fibrosis is partially influenced by the gut microbiota. Chitosan can play a therapeutic role in liver fibrosis by regulating the gut microbiota based on the ‘gut–liver axis’ theory. Salvianolic acid B can inhibit
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RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-09-27 Austin M. Brown, Muni Swamy Ganjayi, Cory W. Baumann
RAD140 is a selective androgen receptor modulator that produces anabolic effects within skeletal muscle. Thus, RAD140 may be effective at treating sarcopenia. No long-term studies have investigated how RAD140 influences strength in ageing muscle. This study aimed to determine how 10 weeks of RAD140 supplementation impacts strength, recovery from exercise, and overall health in ageing mice. Young and
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Anti-prolactin treatment alleviates lupus conditions by regulating the JAK2–STAT3 pathway Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-09-20 Ying Jiang, Huyan Chen, Jinran Lin, Jiewen Pan, Yanyun Shen, Qiao Li
We previously revealed the role of prolactin (PRL) in antibody production and disease activity in patients with systemic lupus erythematosus. In this study, we sought to determine whether inhibition of PRL could improve lupus-like disease in MRL/lpr mice.
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Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-09-19 Rishav Gupta, Divya Soni, Shubham Upadhayay, Maanvi Dhureja, Puneet Kumar
Epilepsy is caused by an excessive recurrent excitatory neuronal firing, characterized by motor, psychomotor, and sensory impairments. Current therapies fail to produce 100% outcomes because of the complexity of the disease, poor diagnosis, and upsurge to drug-resistant epilepsy. The study repurposed the drug ‘noscapine’ mainly known for its anti-tussive properties. For the management of epilepsy and
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Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-09-16 Shaoyuan Zhang, Linyi Sun, Borong Chen, Siyun Lin, Jianmin Gu, Lijie Tan, Miao Lin
Pulmonary fibrosis (PF) is one of the common manifestations of end-stage lung disease. Chronic lung failure after lung transplantation is mainly caused by bronchiolitis obliterans syndrome (BOS) and is mainly characterized by lung tissue fibrosis. Pulmonary epithelial-mesenchymal transformation (EMT) is crucial for pulmonary fibrosis. Telocytes (TCs), a new type of mesenchymal cells, play a protective
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Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-09-09 Guo-Bin Ma, Wen-Xu Chen, Fang-Jie Zhan, Wen-Jing Xie, Rong-Wei Chen, Hong Chen, Wei-Lin Ye, Yu Jiang, Jian-Ping Xu
Myocardial fibrosis (MF) is involved in hypertension, myocardial infarction and heart failure. It has been reported that circular RNA (circRNA) is a key regulatory factor of MF progression. In this study, we revealed that circ_0002295 and CXCR2 were elevated, and miR-1287 was reduced in MF patients. Knockdown of circ_0002295 effectively suppressed the proliferation, migration and MF progression. Circ_0002295
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Rosiglitazone inhibits acyl-CoA synthetase long-chain family number 4 and improves secondary brain injury in a rat model of surgical brain injury Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-09-07 Jinchao Shen, Min Qian, Muyao Wu, Jiafeng Tang, Yating Gong, Jie Li, Jinfen Ji, Baoqi Dang
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Correction to geldanamycin ameliorates multiple organ dysfunction and microthrombosis in septic mice by inhibiting the formation of the neutrophil extracellular network by activating heat shock factor 1 HSF1 Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-08-31
Li, J, Xuan, R, Wu, W, Zhang, H, Zhao, J, Zhang, S. Geldanamycin ameliorates multiple organ dysfunction and microthrombosis in septic mice by inhibiting the formation of the neutrophil extracellular network by activating heat shock factor 1 HSF1. Clin Exp Pharmacol Physiol. 2023; 50(8): 698–707. doi:10.1111/1440-1681.13798 The funding statement for this article was missing. The below funding statement
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Artesunate alleviates psoriasis-like dermatitis by reducing interleukin-23 expression in tumor necrosis factor-alpha-induced HaCaT cells Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-08-27 Lixian Lin, Zhongzhou Huang, Ma Jianchi, Zhixuan Guo, Zhenrui Shi, Zengqi Tang, Qing Guo, Hui Xiong
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Suppression of hypothalamic–pituitary–gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-08-25 Motohiro Tezuka, Saori Yonekubo-Awaka, Yasuaki Tamai, Kumi Tsuchioka, Kaoru Kobayashi, Yu Kuramochi, Satoshi Tatemichi, Tatsuya Nagasawa, Sumiyoshi Kiguchi
The hypothalamic–pituitary–gonadal (HPG) axis is an important regulatory mechanism involved primarily in the development and regulation of the reproductive systems. The suppression of the HPG axis by gonadotropin-releasing hormone (GnRH) analogues is expected to be effective for the treatment of sex hormone-dependent diseases, such as endometriosis, uterine fibroid, prostate cancer, benign prostatic
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Evaluation of right atrium structure and function in a rat model of monocrotaline-induced pulmonary hypertension: Exploring the possible antiarrhythmic properties of amiodarone Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-08-23 Jorge Lucas Teixeira-Fonseca, Julliane Vasconcelos Joviano-Santos, Fabiana da Silva Alcântara, Michael Ramon de Lima Conceição, Polyana Leal-Silva, Danilo Roman-Campos
Atrial arrhythmias (AA) are common in pulmonary hypertension (PH) and are closely associated with poor clinical outcomes. One of the most studied models to investigate PH is the rat model of monocrotaline (MCT) induced PH (MCT-PH). To date, little is known about right atrium (RA) function in the MCT-PH model and the propensity of RA to develop arrhythmias. Therefore, the aim of the study was to evaluate
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Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-08-21 Ting-Wei Zhu, Xue-Lian Li
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Aucubin alleviates methotrexate-induced enteritis in rats by inducing autophagy Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-08-15 Tongao Yang, Wuying Lang, Yun Zhao, Yahan Yang, Hongli Liu, Sufen Li, Xianglong Li, Shuangqi Zhang, Haihua Zhang
One of the toxic side effects of methotrexate (MTX) is enteritis. Aucubin, an iridoid glycoside derived from traditional medicinal herbs, has been proven to have anti-inflammation, anti-apoptosis and anti-oxidation properties. This work explored the effect and mechanism of aucubin in treating MTX-induced enteritis in a rat model. Two doses of aucubin (5 and 10 mg/kg) were adopted for the assessment
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Ligustrazine and liguzinediol protect against doxorubicin-induced cardiomyocytes injury by inhibiting mitochondrial apoptosis and autophagy Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-08-13 Naqi Lian, Jing Tong, Weijie Zhu, Qinghai Meng, Miao Jiang, Mianli Bian, Yu Li
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Intraoperative hemodynamics and risk of cardiac surgery-associated acute kidney injury: An observation study and a feasibility clinical trial Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-08-07 Khin M. Noe, Andrea Don, Andrew D. Cochrane, Michael Z. L. Zhu, Jennifer P. Ngo, Julian A. Smith, Amanda G. Thrift, Johnny Vogiatjis, Andrew Martin, Rinaldo Bellomo, James McMillan, Roger G. Evans
Targeting greater pump flow and mean arterial pressure (MAP) during cardiopulmonary bypass (CPB) could potentially alleviate renal hypoxia and reduce the risk of postoperative acute kidney injury (AKI). Therefore, in an observational study of 93 patients undergoing on-pump cardiac surgery, we tested whether intraoperative hemodynamic management differed between patients who did and did not develop
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Role of the chloride channel blocker in the formation of filtering tract scars after glaucoma surgery in rats Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-07-15 Yujiao Jin, Weiyi Jin, Qiushuang Sun, Nan Li, Meiling Jiang, Yinfeng Liu, Lixia Sun
Filtration surgery is commonly performed for glaucoma treatment to reduce intraocular pressure (IOP); however, scarring of the filtering bleb is the main cause of failure. In this study, we evaluated the effects of the chloride channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) on scar formation in filtering blebs. A glaucoma filtering surgery model was generated using Sprague–Dawley
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Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2 Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-07-15 Qiuhua Ying, Jinjie Lou, Daibo Zheng
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Esculentoside A ameliorates DNCB-induced atopic dermatitis by suppressing the ROS-NLRP3 axis via activating the Nrf2 pathway Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-07-13 Tao Liu, Yuanmin He, Yongmei Liao
Atopic dermatitis (AD) is a chronic inflammatory skin condition with a high prevalence. Inflammation and oxidative stress are strongly associated with AD progression. Esculentoside A (EsA) inhibits inflammation and oxidative stress in various diseases. However, whether EsA mitigates AD by suppressing inflammation and oxidative stress remains unknown. A mouse model of AD was constructed by the induction
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Diosmetin-7-O-β-D-glucopyranoside suppresses endothelial–mesenchymal transformation through endoplasmic reticulum stress in cardiac fibrosis Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-07-10 Huahua Wang, Xiaoyu Zhang, Yangyang Liu, Yunyun Zhang, Yingyu Wang, Yunru Peng, Yongfang Ding
Diosmetin-7-O-β-D-glucopyranoside (Diosmetin-7-O-glucoside) is a natural flavonoid glycoside known to have a therapeutic application for cardiovascular diseases. Cardiac fibrosis is the main pathological change in the end stage of cardiovascular diseases. Endothelial-mesenchymal transformation (EndMT) induced by endoplasmic reticulum stress (ER stress) via Src pathways is involved in the process of
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Moxibustion ameliorates cerebral ischemia–reperfusion injury by regulating ferroptosis in rats Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-07-07 JingRuo Zhang, Wa Cai, Xifang Wei, Yanbo Shi, Kun Zhang, Chen Hu, Jie Wan, Kaitao Luo, Weidong Shen
Moxibustion is an effective treatment for the clinical management of acute cerebral infarction. However, its exact mechanism of action is still not fully understood. This study aimed to investigate the protective effect of moxibustion on cerebral ischemia–reperfusion injury (CIRI) in rats. Middle cerebral artery occlusion/reperfusion (MCAO/R) was used to construct a CIRI rat model, all animals were
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Prognosis of early-stage lung adenocarcinoma in young patients Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-07-06 Yaping Jia, Qiuliang Ji, Lei Zhang, Yunlang She, Minghang Su, Zhe Shi
Lung adenocarcinoma (LUAD) is a familiar lung cancer with a poor prognosis. This study was meant to determine whether there are differences in survival between younger and older patients with early-stage LUAD because of the rise in the incidence of LUAD in young individuals over the previous few decades. We analysed the clinical, therapeutic and prognostic features of a cohort (2012-2013) of 831 consecutive
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Deficiency of leukotriene B4 receptor type 1 ameliorates ovalbumin-induced allergic enteritis in mice Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-07-05 Shinichi Kato, Suzuka Onishi, Misaki Sasai, Hiroyuki Yasuda, Kazuko Saeki, Kenjiro Matsumoto, Takehiko Yokomizo
Leukotriene B4 receptor type 1 (BLT1), a high-affinity receptor for leukotriene B4 (LTB4), plays an important role in inflammatory responses, including allergic airway inflammation. In this study, we examined the effect of genetic BLT1 deletion (BLT1KO) on ovalbumin (OVA)-induced allergic enteritis in mice to determine the pathogenic role of LTB4/BLT1 in allergic enteritis, a gastrointestinal form
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Effect of SH2B1 on glucose metabolism during pressure overload-induced cardiac hypertrophy and cardiac dysfunction Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-07-03 Beilei Liu, Xuguang Liu, Shan Hu, Shuai Mao, Manqi Yang, Bin Wu, Gang Wu
This study mainly explored the effect and mechanism of Src homology 2 (SH2) B adaptor protein 1 (SH2B1) on cardiac glucose metabolism during pressure overload-induced cardiac hypertrophy and dysfunction. A pressure-overloaded cardiac hypertrophy model was constructed, and SH2B1-siRNA was injected through the tail vein. Haematoxylin and eosin (H&E) staining was used to detect myocardial morphology.
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Valproic acid reduces muscle susceptibility to contraction-induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-06-29 Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, Arnaud Ferry
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3-aminohydantoin derivate as a promising scaffold in dopaminergic neuroprotection and neurorescue in the in vivo and in vitro 6-hydroxydopamine models of Parkinson's disease Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-06-18 Sahar Mani, Houda Bouchnak, Solène Pradeloux, Jamil Kraiem, Denis Soulet, Imed Messaoudi
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra, for which no disease-modifying treatments are available yet. Thus, developing new neuroprotective drugs with the potential to delay or stop the natural course of the disease is necessary. The aim of the present study was to evaluate the neuroprotective effects
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Brazilin inhibits bladder cancer by promoting cell necroptosis Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-06-15 Xihua Yang, Shuaina Zhang, Jiao He, Lili Zhao, Lixia Chen, Yongming Yang, Jing Wang, Lei Yan, Tingting Zhang
Brazilin possesses anticancer effects, but the mechanisms are poorly understood. This study investigated the mechanisms of brazilin-induced cell death in the T24 human bladder cancer cell line. Low serum cell culture and the lactate dehydrogenase assay were used to confirm the antitumor effect of brazilin. Annexin V and propidium iodide double staining, transmission electron microscopy, fluo-3-AM assay
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Effect of renal denervation on cardiac remodelling and function in rats with chronic intermittent hypoxia Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-06-13 Dasheng Lu, Kai Wang, Wanying Jiang, Hao Zhang, Hongxiang Zhang
Chronic intermittent hypoxia (CIH) mimicking obstructive sleep apnea elicits divergent outcomes in the cardiovascular systems. The effect of renal denervation (RDN) on the heart during CIH remains unclear. We aimed to explore the effect of RDN on cardiac remodelling in rats exposed to CIH and to discuss the underlying mechanisms. Adult Sprague Dawley rats were divided into four groups: control, control+RDN
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Geldanamycin ameliorates multiple organ dysfunction and microthrombosis in septic mice by inhibiting the formation of the neutrophil extracellular network by activating heat shock factor 1 HSF1 Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-06-12 Jing Li, Ruijing Xuan, Weidong Wu, Hailong Zhang, Jie Zhao, Shan Zhang
Sepsis and septic shock are common critical illnesses in the intensive care unit with a high mortality rate. Geldanamycin (GA) has a broad spectrum of antibacterial and antiviral activity and has inhibitory effects on various viruses. However, whether GA affects sepsis due to infections remains unknown. In this study, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen and creatinine
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Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-06-12 Juan Gao, Gang Su, Wei Chen, Qionghui Wu, Junxi Liu, Jifei Liu, Miao Chai, Ying Dong, He Wang, Lixia Chen, Zhenchang Zhang, Manxia Wang
Ligustilide, a natural phthalide mainly derived from chuanxiong rhizomes and Angelica Sinensis roots, possesses anti-inflammatory activity, particularly in the context of the nervous system. However, its application is limited because of its unstable chemical properties. To overcome this limitation, ligusticum cycloprolactam (LIGc) was synthesized through structural modification of ligustilide. In
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Rosavin protects the blood–brain barrier against ischemia/reperfusion-induced cerebral injury by regulating MAPK-mediated MMPs pathway Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-05-31 Hongyun Zou, Lei Li, Zhilai Yang, Lili Tang, Chunhui Wang
Ischemia–reperfusion (I/R) injury is a common pathophysiological condition in ischemic stroke, involving various pathophysiological events, such as inflammation, cytotoxicity, neuronal loss and disruption of the blood–brain barrier (BBB). Rosavin is the major bioactive ingredient of Rhodiola Rosea L. with multiple therapeutic effects. The purpose of this was to investigate the role of rosavin in I/R-induced
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Bufalin reduces myocardial infarction-induced myocardial fibrosis and improves cardiac function by inhibiting the NLRP3/IL-1β signalling pathway Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-05-27 Xiang Wei, Yang Lv, Chenxi Yang, Rifeng Gao, Su Zou, Yingjia Xu
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Combination of SVI/S′ and diagnostic scores for heart failure with preserved ejection fraction Clin. Exp. Pharmacol. Physiol. (IF 2.9) Pub Date : 2023-05-19 Guanyu Mu, Weiding Wang, Changle Liu, Juan Xie, Hao Zhang, Xiaowei Zhang, Jingjin Che, Gary Tse, Tong Liu, Guangping Li, Huaying Fu, Kangyin Chen
The diagnosis of heart failure with preserved ejection fraction (HFpEF) remains a challenge. There are three methods proposed as diagnostic tools. H2FPEF score was determined by six weighted clinical characteristics and echocardiographic variables. Heart Failure Association (HFA)-PEFF algorithm consists of various functional and morphological variables as well as natriuretic peptides. SVI/S′ is a novel