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Novel insulin-montmorillonite sodium complex containing pH regulated nanocomposite hydrogels J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-14 Farya Shabir, Asif Mahmood, Muhammad Zaman, Rai Muhammad Sarfraz, Hira Ijaz, Muhammad Umar Ashraf, Heba A. Gad
Main objective of current work was to develop pH responsive polymeric systems for safe oral delivery of insulin. A novel fenugreek seed mucilage extract-based pH-regulated hydrogel (FA) system by free radical polymerization. Insulin was directly post-loaded in developed hydrogels (I-FA) as well as in the form of insulin-montmorillonite-Na + complexes (I-MT) to prepare nanocomposite (NC) hydrogels (I-MT-FA)
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Fucoidan-incorporated dissolving microneedles: A novel approach to anticoagulant transdermal delivery J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-14 Stephanie Stephanie, Cindy Kristina Enggi, Sulistiawati Sulistiawati, Frederika Tangdilintin, Alghifary Anas Achmad, Magdalena Litaay, Burkhard Kleuser, Marianti A. Manggau, Andi Dian Permana
Cardiovascular disease (CVD) is the leading cause of global mortality, particularly in Indonesia. Vascular disorders, including thrombosis and atherosclerosis, have been implicated as potential contributors to the development and progression of CVDs. Anticoagulant agents, such as heparin, have been commonly used to treat vascular disorders. Nevertheless, this agent may result in a hazardous adverse
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Aptamer-functionalized liposome delivery system targeting adipose for hypereffective obesity therapy J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-14 Yuhan Song, Yanzhou Hu, Ruxin Gao, Qiaoying Chang, Xiaoyun He, Guofang Pang, Wentao Xu
Preparation of DNA micro/nanostructures with high accuracy, high effectiveness, and low toxicity remains a challenge in the fields of biotargeting drugs and therapeutics. Aptamer-liposome-nordihydrocapsaicin-encapsulated nanosystems (ALN) were constructed via film dispersion ultrasonication using liposome-anchored aptamers for synergistic obesity treatment. In this design, 71 nucleotide (nt) long of
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NiWo4- RGO composite exerts cytotoxic effects on pancreatic carcinoma cells via a cross-talk between reactive oxygen species-independent canonical autophagy of the mitochondria and epithelial-mesenchymal transition J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-14 Ziyu Jiang, Jing Ni, Songyang Zhou, Liu Yang, Xing Huang, Jingbing Liu, Jun Bao
Nanotechnology for its appliance in medicine ranges from several applications such as in biosensors, drug carriers and nanomaterials as drug possibilities or cytotoxic agents without a drug being loaded onto them. Based on this intention, Nickel tungstate- Reduced graphene oxide (NiWO-RGO) nanocomposites were prepared and characterized by fourier-transform infrared spectroscopy (FTIR), X-Ray diffraction
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The optimization strategies of LNP-mRNA formulations: Development and challenges for further application J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-14 Sizhen Wang, Beibei Guo, Huan Wang, Feng Yang
Since the successful development and application of the COVID-19 mRNA vaccine, lipid nanoparticle (LNP)-based nucleic acid delivery therapy has received much attention, and the technology is increasingly mature, gradually becomes an innovative means to treat various diseases. Although the LNP-mRNA therapy has become an effective treatment, several challenges still remained for clinical application
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Emerging trends in nano-carrier based gene delivery systems for targeted cancer therapy J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-14 Rohit Bhatia, Amandeep Singh, Sukhwinder Singh, K. Navneesh, Ravindra Kumar Rawal
Gene therapy has been proven to be a blockbuster therapeutic strategy to cure a wide variety of life-threatening human ailments including cancer, neurodegenerative and autoimmune disorders. Cancer is the most dreadful among them and growing in an irrational proportion throughout the globe. Researchers are continuously exploring novel approaches to ensure the efficacy and safety of gene-based drug delivery
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Green synthesis, characterization, anti-cancer and antimicrobial activity of AuNPs extracted from Euphorbia antiquorum stem and flower: Experimental and theoretical calculations J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-13 G. Venkatesh, G. Serdaroğlu, E. Üstün, D. Haripriya, P. Vennila, V. Siva, S. Haseena, V. Sowmiya, A. Pradhiksha
Green nanoparticles derived from medicinal plants have attained popularity in recent years. Gold nanoparticles, with their distinct biological properties, are being investigated. Several studies have shown that gold nanoparticles are effective in anticancer treatments. In this study, (EA) extract was used in the green synthesis of gold nanoparticles. The gold nanoparticles (EA-AuNps) were studied with
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Tailored binary polymer system PCL-PEO for advanced biomedical applications: Optimization, characterization and in vitro analysis J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-13 Ayda Afshar, Hamta Majd, Anthony Harker, Mohan Edirisinghe
Combining a hydrophobic polymer such as polycaprolactone (PCL) with a hydrophilic polymer polyethylene oxide (PEO) in a binary polymer system can enable a range of novel applications in biomedical engineering by permitting exceptional therapeutic release, antimicrobial possibilities, and heterogeneous tissue engineering scaffolds. In this work, both PCL and PEO were dissolved in chloroform at 15 w/v
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Colon-targeted 3D-Printed mesalamine tablets: Core-shell design and in vitro/ex-vivo evaluation J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-13 Nouf D. Alshammari, Ahmed Almotairy, Mashan Almutairi, Peilun Zhang, Esraa Al Shawakri, Sateesh Kumar Vemula, Michael A. Repka
The present study is intended to develop a shell-core tablet using a hot melt extrusion (HME)-based dual-nozzle fused deposition modeling (FDM) three-dimensional (3D) printing approach. The primary objective was to establish a sustained-release colonic drug delivery system and improve mesalamine's permeability by incorporating Vitamin E TPGS as a permeation enhancer. The study utilized Kollidon® SR
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Silk fibroin-based hydrogel as injectable carrier for prolonged immunization of plant-based COVID-19 subunit vaccine J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-13 Nopparuj Soomherun, Ruttanaporn Kriangsaksri, Wanlapa Tanticharakunsiri, Ngamlak Foongsawat, Waranyoo Phoolcharoen, Supannikar Tawinwung, Saran Keeratihattayakorn, Juthamas Ratanavaraporn
Silk fibroin (SF)-based hydrogel was prepared to serve as an injectable carrier, aimed at prolonging the immunization effect of the plant-derived vaccine for the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). This vaccine consists of the Receptor-Binding Domain (RBD) linked with the Fragment Crystallizable (Fc) region of Human Immunoglobulin G 1 (IgG1), also referred to as the RBD-Fc vaccine
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Hydrogel-based drug delivery systems for synergistic chemo/hyperthermia therapy of cancer: A comprehensive review J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-12 Mehdi Jaymand
The most popular cancer treatment protocols are surgery, radiation therapy, and chemotherapy. Amongst, chemotherapy has received more interest owing to some superior advantages such as adjuvants to local therapy as well as simplicity, availability, and excellent efficacy at suitable dosage. Despite, some drawbacks ( side effects, drug resistance, low efficiency due to dose-limiting toxicity, and pour
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Assessment of nanocarrier mediated afatinib pharmacokinetic: A comparative in-vivo study in rat model for enhanced therapeutic efficacy in lung cancer management J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-12 Jigar Vanza, Diwyanshi Zinzuvadia, Hardik Koria, Jigar Lalani, Rashmin B. Patel, Mrunali R. Patel
Nanocarrier-based drug delivery systems are at the forefront of innovative research in the field of medical science, providing potential pathways for treatments across several routes of administration. Notably, a great deal of research has gone into maximizing the potential of polymeric nanoparticles and liposomes, with a focus on addressing the intricacies of lung cancer through the pulmonary route
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Antimicrobial peptides as antimicrobials for wound care management: A comprehensive review J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-12 Kunal Agam Kanaujia, Nidhi Mishra, P.S. Rajinikanth, Shubhini A. Saraf
Antimicrobial peptides (AMPs) are low-molecular-weight proteins having a presence in almost all organisms, from prokaryotes to eukaryotes, and have been a fundamental part of the innate immune system. The AMPs primarily have cationic charges and amphipathic structures. This positive charge leads to electrostatic interactions between the AMPs and the anionic phospholipidic microbial cellular membrane
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In vitro and in vivoassessment of gallic acid-chitosan/polycaprolactone conjugate electrospun nanofibers for wound healing J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-12 Vinita Patole, Pratiksha Bhosale, Ganesh Ingavle, Isha Behere, Nikita Vyawahare, Divya Ottoor, Avinash Sanap, Ramesh Bhonde, Supriya Kheur
The development of innovative multifunctional wound healing materials based on natural bioactives has attracted a great deal of attention in recent years due to their ability to potentiate the healing process and minimize the challenges linked with conventional wound dressings. The current study demonstrates the development and evaluation of a novel nanofibrous wound healing mat made of Gallic acid-chitosan
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PLGA nanoparticles for nasal drug delivery J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-12 Salah Alghareeb, Kofi Asare-Addo, Barbara R. Conway, Adeola O. Adebisi
The nasal route has routinely been used in the local delivery of drugs, however with innovations in nanotechnology, there has been increased interest in exploring this route more for systemic, and brain/CNS delivery. This is because this route is safe, non-invasive, and medications can be self-administered to achieve rapid therapeutic drug levels with minimal doses. Polymeric nanoparticles (NPs) such
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Synthesis of chitosan-graphene oxide thermosensitive in situ hydrogel for nasal delivery of rasagiline mesylate: In-vitro-ex vivo characterization J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-12 Suhas Mahajan, Sopan Nangare, Abhinav Chaudhari, Ganesh Patil
Intranasal administration of a drug offers a way to bypass the blood-brain barrier, allowing for an increased drug concentration in the brain and improved bioavailability. In this context, the preference for polymeric thermoresponsive intranasal hydrogels has been widely documented. Here, there is a need to enhance the physical properties of the hydrogel and improve control over the release of the
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Development and evaluation of high permeability liposomes for improving anti-melanogenic activity of taxus chinensis fruit polysaccharide J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-12 Xuepeng Lv, Xinyue Wang, Fangfang Shi, Yingqi Lu, Yuexia Han, Hao Wang, Fei Xiong
var. mairei fruit polysaccharide (TMFP) is a natural resource with effective hypoglycemic and anti-tumor properties. However, its impact on melanogenesis remains largely unexploited. This study explores the anti-melanogenic activity of TMFP using and models. It was found that TMFP can safely and effectively eliminate melanin and inhibit tyrosinase activity without cytotoxicity. More specifically, the
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Rolled-up gastroretentive oral dosages for controlled release of riboflavin and propranolol J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-11 Jihane Mzoughi, Quoc Hung Tran, Gautier Schrodj, Thierry Vandamme, Valeriy Luchnikov
We present a simple approach to make gelatin gastroretentive oral dosages for controlled release of riboflavin and propranolol. The approach is based on rolling-up of thin self-adhesive gelatin films, on which the reservoirs of the drugs are formed by casting. The radial position of the reservoir and, hence, the lag time and the rate of the drugs release are determined by the lateral position of the
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Exosomes as new generation vehicles for drug delivery systems J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-11 N. Dilsiz
Exosomes are the smallest subtype of mobile extracellular vesicles (EVs), and round sacs with a diameter between 30 and 120 nm are released by almost all cell types into the surrounding biological fluids. They are increasingly becoming recognized as critical cell-to-cell communication mediators. Exosomes derived from cells contain particular biomolecules that can be regarded as a “fingerprint” of the
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Compatibility study of formoterol fumarate-lactose dry powder inhalation formulations: Spray drying, physical mixture and commercial DPIs J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-11 Aiesheh Gholizadeh-Hashjin, Farnaz Monajjemzadeh, Taravat Ghafourian, Hamed Hamishehkar, Ali Nokhodchi
Formoterol fumarate (FF) is a long-acting beta-adrenergic receptor agonist that is administered as a dry powder inhaler (DPI) for chronic respiratory conditions. In most DPI formulations, the drug substance and the carrier are the two major components. Lactose is the most common carrier, which can undergo a Maillard reaction in the presence of primary and secondary amines. FF contains a secondary amine
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In vivo predictive dissolution of the lipophilic phytochemicals trans-resveratrol, coenzyme Q10 and quercetin J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-11 Marvin Benedikt Brenner, Matthias Wüst, Jan Frank, Karl G. Wagner
Biphasic dissolution consisting of an aqueous dissolution and an overlaying organic distribution compartment, is an innovative screening approach for the oral bioavailability of pharmacologically active compounds. As -relevant dissolution methods predicting the bioavailability of compounds from natural extracts are lacking, we sought to establish and validate an predictive biphasic dissolution method
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Dual pH and ultrasound responsive nanocarriers: A smart approach in cancer theranostics J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-11 Aditi Kaushik, Saboor Khan, Nandini Pharasi, Shalini Mani
Tremendous breakthroughs in nanotechnology have fuelled an explosion of highly refined and tailored drug methods in recent years. Sensor-based nanocarriers are establishing themselves as an intriguing frontier, potentially reshaping the terrain of precision medicine. pH-based nanocarriers have received interest for their potential to improve cancer therapy by taking advantage of the acidic environment
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18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-09 Keshav Raj Paudel, Mohamad Siddiq Bin Mohamad, Gabriele De Rubis, Ruby-Jean Reyes, Nisha Panth, Harish Dureja, Gaurav Gupta, Sachin Kumar Singh, Thiagarajan Madheswaran, Trudi Collet, Philip Michael Hansbro, Kamal Dua, Dinesh Kumar Chellappan
Conventional treatment methods to treat lung cancer include radiation therapy, chemotherapy, and immunotherapy. However, they cause severe adverse effects and recurrence risk. 18-β-glycyrrhetinic acid (18-β-Gly), a naturally occurring bioactive compound extracted from the liquorice plant has demonstrated anticancer potential by suppressing cancer cell growth, angiogenesis, and metastasis. Although
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Oral fast dissolving films for co-administration of breviscapine and matrine: Formulation optimization and in vitro characterization J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-08 Huiyun Yin, Wenbin Jin, Jiao Wang, Jin Ke, Wenping Zhang, Chen Liu, Wenping Wang
Oral fast dissolving films (OFDFs) are popular dosage forms for enhanced oral absorption of active ingredients without experiencing gastrointestinal interference or first-pass metabolism. The primary challenge in OFDF design is balancing drug loading capacity with film properties, particularly for poorly soluble drugs. In the present work, an OFDF formulation containing co-amorphous mixture was successfully
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Transferosomes as innovative drug delivery systems for enhanced antifungal therapy: A comprehensive review J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-07 Sakshi Chamel, Anamika Mishra, Azka Gull
A fungal infection or mycosis is a disease that can affect humans in various ways. These pathogens, being eukaryotic organisms, can invade their eukaryotic hosts, leading to superficial, sub-cutaneous, or systemic infections. Though most of the fungal infections are cutaneous, if the immune system is impaired, it can turn into systemic infection, having higher morbidity and mortality rates. Thus, antifungal
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Diclofenac derivatives as promising anticancer and anti-inflammatory drug: Synthesis, formulations, and pharmacokinetics J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-07 Arwa Alshargabi
Diclofenac (DCF) is well-known non-steroidal anti-inflammatory drug used in the treatment of several cancer cell lines. DCF is derived from phenylacetic acid, and its pharmaceutical activity is attributed to the carboxylic acid moiety. The carboxylic acid group is also responsible for the DCF's side effects, which include gastrointestinal bleeding and ulceration. Therefore, researchers do vast efforts
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Enhancing antibacterial activity against multi-drug resistant wound bacteria: Incorporating multiple nanoparticles into chitosan-based nanofibrous dressings for effective wound regeneration J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-07 Zahra Asvar, Neda Pirbonyeh, Amir Emami, Seyedeh-Sara Hashemi, Milad Fadaie, Alireza Ebrahiminezhad, Esmaeil Mirzaei
Wound infection continues to pose a significant challenge in the field of wound healing. Multi-drug resistant bacteria (MDR) make it even more complicated. Therefore, there is a pressing need to fabricate wound dressings with enhanced antimicrobial activity, particularly against MDR strains. In this study, we aimed to incorporate three antimicrobial nanoparticles into a chitosan-based nanofibrous mat
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Sertaconazole-PLGA nanoparticles for management of ocular keratitis J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-07 Nermin E. Eleraky, Mohamed A. Attia, Mohamed A. Safwat
Ocular fungal infections can pose severe health conditions that may develop into vision impairment and blindness. Sertaconazole (STZ) is a widely used antifungal; however, its low aqueous solubility restricts its topical application for managing ocular keratitis. This investigation aimed to develop polymeric nanoparticles as delivery carriers to improve the ophthalmic availability of STZ for treating
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Dissolving microneedle to improve transdermal delivery of terbinafine for treatment of onychomycosis J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-07 Lulu An, Yuanyuan Wang, Jiaan Wu, Xiaoping Liu, Mei Liu, Siyue Kan, Yan Li, Yongyong Li, Jingwen Tan, Lianjuan Yang
The topical formulation of antifungal agents has demonstrated prominent success in treating fungal infection. However, traditional topical cream or solution limited ability to penetrate the nail plate and target the infected area contributes to the inefficacy of antifungals in the treatment of onychomycosis. In this work, the problem of topical administration reaching only the skin's surface was addressed
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Co-delivery of epirubicin and letrozole using a metal-organic framework nanoparticle in breast cancer therapy J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-07 Atieh Hashemi, Seyed Reza Hayat-Gheibi, Fahimeh Baghbani-Arani
Combination chemotherapy is a viable approach for cancer treatment in clinics when dealing with multidrug-resistant cancer. The difficulty of concentrating medications in drug-resistant cancers remains a substantial issue, making it challenging to get sufficient multi-drug delivery into tumour cells to enhance the synergetic therapeutic effect. To enhance combination therapy, we fabricated metal-organic
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Development and characterization of plant derived wastes Nano-formulation loaded in thermo-reversible gel for burn healing: An effort towards Sustainable Development J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-06 Samar M. Bassam, Dalia E. Ali, Zeinab M. Awwad, Shimaa A. Mahmoud, Basant A. Abou-Taleb
The duty of research is to suggest solutions to ailments affecting humans. Recently, there has been a demand that these solutions should be environmentally responsible, eco-friendly and coincide with sustainable development goals. From this perspective, the objective of this study was to develop thermo-reversible and healing promoting gel formulations. The gel base incorporated Natural Plant derived
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Gas foamed scaffolds as smart 3D structures in skin tissue engineering J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-06 Eleonora Bianchi, Marco Ruggeri, Barbara Vigani, Carlotta Totaro Fila, Antonia Icaro Cornaglia, Cinzia Boselli, César Viseras, Silvia Rossi, Giuseppina Sandri
Globally, wound care is a major problem that poses big issues for national healthcare systems. Consequently, the development of wound dressings, systems applied over a wound to prevent complications and speed up recovery, is receiving increasing attention. Electrospun nanofibrous scaffolds gained great interest in the medical field due to their many advantages and beneficial characteristics. However
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S-protected thiolated surfactants enhancing surface properties of lipid-based nanocarriers J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-06 Gennaro Balenzano, Giuseppe Francesco Racaniello, Miriam Domenica Panzarino, Patrick Knoll, Martyna Truszkowska, Valentino Laquintana, Andreas Bernkop-Schnürch, Nunzio Denora
This work aimed to investigate the influence of surface decoration of orally administered lipid-based nanocarriers (LNCs) through S-protected thiolated surfactant on key properties such as mucodiffusion, adhesion and cellular uptake. This comparative study with simple thiolation was performed on chemically modified polyoxyethylene stearyl ether (PSE) surfactant with different PEG chains exhibiting
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Experimental screening and molecular dynamics simulation study on wetting agent in dry suspension J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-05 Minfang Feng, Yuting Tian, Yingying Zhang, Cuiting Yang, Xinhui Peng, Shuai Cen, Mengke Sheng, Zhixun Li, Qing Zhou, Xingxing Dai, Xinyuan Shi
Suspension is the common preparation whose absorption rate is second only to the solution. However, problems like the difficulty in screening excipients and the complicated screening process limit its application to a certain extent. In this study, trimethoprim (TMP) was used as the research object. Compound sulfachlorpyridazine sodium Powder(CSSP) containing TMP was used as the research vector to
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Microemulsion containing guava leaves essential oil: Enhanced anti-inflammatory, anti-oxidation, anti-tyrosinase activities and skin permeation J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-04 Parichat Sutthisawatkul, Prachayawat Piyanaetitham, Theeraphap Chareonviriyaphap, Theerachart Leepasert, Weerasak Taengphan, Thitinun Karpkird
In this study, a microemulsion system containing guava leaf essential oil (GLE) was developed to enhance water miscibility, stability and bioactivity. The major chemical components of GLE, -limonene, and β-caryophyllene, were identified by GC-MS analysis. The microemulsion system consisted of Tween 80 and propylene glycol as the surfactant (S) and co-surfactant (Co–S), respectively, with GLE serving
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Improving oral absorption of tretinoin by ionic liquids technology J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-04 Jingjing Xuan, Xiying Wu, Lisha Li, Jianping Qi, Xiuhong Lu, Jie Zhuang
Oral delivery of the hydrophobic tretinoin (Tre) is a significant challenge due to poor solubility and bioavailability. Here, we describe the potential of ionic liquids (ILs, e.g., [Ch][Ger]), in particular active pharmaceutical ingredient-based ILs (API-ILs, e.g., [Ch][Tre]) and their mixtures (e.g., [Ch][Tre]-[Ch][Ger]), for oral delivery of Tre. [Ch][Tre] provided excellent apparent solubility of
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Hybrid nanocomposite wound dressings by a novel nanorod vitamin-B3-Ag metal-organic framework and bacterial cellulose nanofibers J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-04 Mahdi Barjasteh, Seyed Mohsen Dehnavi, Shahab Ahmadi Seyedkhani, Mehrdad Akrami, Marzieh Rahimi
This paper presents a novel nanorod metal-organic framework made of silver nods configured within nicotinic acid (vitamin-B3) linkers (AgNA) aimed at wound healing applications. X-ray diffraction analysis indicated that the synthesized AgNA MOFs comprised of zigzag chains of silver (I) nicotinate with orthorhombic crystal structure. Electron microscopy showed nanorod structures for the MOFs with uniform
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Polycaprolactone/graphene oxide/magnesium oxide as a novel composite scaffold for bone tissue engineering: Preparation and physical/biological assessment J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-04 Zahra Niknam, Anahita Fathi Azarbayjani, Seyed Mahdi Rafiaei, Yousef Rasmi, Lobat Tayebi
Mechanically robust biocomposite scaffolds were fabricated by the electrospinning method for bone tissue engineering using a blend of polycaprolactone (PCL), and graphene oxide (GO) with magnesium oxide (MgO) nanoparticles. Physicochemical characteristics including morphology, tensile strength, swelling behavior, biodegradability, contact angle, cell viability, alkaline phosphatase (ALP) activity,
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Polydopamine coated surfactin micelles for brain delivery of ibudilast in multiple sclerosis: Design, optimization, in vitro and in vivo evaluation J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-04 Akram sharifian, Jaleh Varshosaz, Mehdi Aliomrani, Mohammad Kazemi
Ibudilast inhibits TNF-α and IL-12 release from the astrocytes and microglial cells, reducing neuronal degeneration and may be a potential therapy in multiple sclerosis with neuroprotective effects. Our study aimed to prepare polydopamine coated micelles of surfactin, a biosurfactant, loaded with ibudilast to control the release and its targeted delivery through nose to the brain by targeting D2-like
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Effect of oxidation state and chelating agent on iron bio-accessibility from different commercial iron-supplements J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-04 Simone Pepi, Luigi Talarico, Gemma Leone, Claudia Bonechi, Gabriella Tamasi, Ilaria Clemente, Marco Consumi, Flavia Bisozzi, Francesca Ietta, Claudio Rossi, Agnese Magnani
Oral iron-supplementation represents the most common treatment for iron deficiency, a widely diffused mineral insufficiency. Seven commercial products containing different chelating agents (i.e. lipidic Fe (III)-pyrophosphate, Fe (III)-pyrophosphate, lipidic Fe (II)-sulphate, Fe (III)-saccharate and Fe (III)-EDTA) were analyzed. Infrared and thermal analyses highlighted that ferrous ions complexes
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Rosuvastatin-laden nanofibrous patches for effective treatment of corneal ulcer in experimental animals J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-04 Abdelrahman M. Helmy, Asmaa A. Hamed, Ahmed A. Abdelghany, Sara Mohamed Naguib Abdel Hafez, Waleed M.A. El Rouby, Usama F. Aly
Corneal ulceration is a "silent epidemic" that impacts laborers’ lives, particularly in low-income countries, and calls for a unique ophthalmic drug delivery strategy that overcomes ocular barriers to promptly achieve therapeutic outcomes while remaining cost-effective. Rosuvastatin, a third-generation statin that significantly accelerates tissue regeneration and wound healing, could be proposed as
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An injectable in situ hydrogel platform for sustained drug release against glioblastoma J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-03 Weizhou Yue, Tianqi Wang, Lingxiao Xie, Jie Shen
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Despite aggressive surgical and medical treatments, the prognosis for patients with GBM remains grim and tumor recurrence is inevitable. Long-acting localized chemotherapy can not only reduce systemic toxicity, but also maintain chemotherapeutic concentration at the tumor sites over prolonged duration, thereby having
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Transdermal delivery of IBU-PLGA nanoparticles with dissolving microneedle array patch J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-02 Fan Yang, Wei Wang, Jing Zhou, Zhoubing Yu, Mingwei An, Wenxuan He, Yun Xue, Fan Chen
There are few systematic studies using microneedles to deliver ibuprofen through the skin. In this study, Ibuprofen was encapsulated in poly (lactide-co-Glycolide) (PLGA) network to form nanoparticles(IBU-NPs), then the IBU-NPs were mixed with Sodium Hyaluronate to fabricate dissolving microneedles array patch (MNP) and applied in mice model to observe its effect. In mouse model, IBU-NPs microneedles
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Corrigendum to “A technological comparison of freeze-dried poly-ɛ-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery” [J. Drug Deliv. Sci. Technol. 93 (March 2024), 105419] J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-02 Rosamaria Lombardo, Marika Ruponen, Jarkko Rautio, Riikka Lampinen, Katja M. Kanninen, Anne M. Koivisto, Elina Penttilä, Heikki Löppönen, Sara Demartis, Paolo Giunchedi, Giovanna Rassu, Maria Elena Fragalà, Rosario Pignatello
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Beyond traditional hydrogels: The emergence of graphene oxide-based hydrogels in drug delivery J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-01 Renu Saharan, Sarvesh K. Paliwal, Abhishek Tiwari, M. Arockia Babu, Varsha Tiwari, Randhir Singh, Suresh Kumar Beniwal, Manish Kumar, Ajay Sharma, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Neelima Kukreti, Gaurav Gupta
Hydrogel applications in various medical fields especially in drug delivery have been widely investigated in the last few years. Introduction of biopolymers in the production of hydrogels leads to develop biodegradable, biocompatible, and non-immunogenic drug carriers. However, possessing such remarkable properties the role of hydrogels is still limited in drug delivery because of the factors such
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Polyvinyl pyrrolidone/starch/hydroxyapatite nanocomposite: A promising approach for controlled release of doxorubicin in cancer therapy J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-01 Bahar Kazem Borji, Mehrab Pourmadadi, Alireza Tajiki, Majid Abdouss, Abbas Rahdar, Ana M. Díez-Pascual
Doxorubicin (DOX) is an effective and widely used cancer chemotherapy drug, though its use is extremely dangerous due to side effects such as cardiotoxicity resulting from high doses. Herein, a sustainable and biocompatible starch/polyvinyl pyrrolidone/hydroxyapatite nanocomposite was prepared and loaded with DOX by water-in-oil-in water (W/O/W) emulsification method. Fourier-transform infrared spectroscopy
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Multifunctional polypeptide-based polymersome for chemophotothermal therapy of melanoma in vitro and in vivo J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-01 Maliheh Hasannia, Khalil Abnous, Seyed Mohammad Taghdisi, Ameneh Sazgarnia, Sirous Nekooei, Mohammad Ramezani, Mona Alibolandi
To date, combination therapy using chemo-photothermal therapy (Ch-PTT) has attracted tremendous interest due to its efficient ablation of cancerous cells. Furthermore, there are several advantages to using peptide-based nanocarriers for theranostic nanoplatforms, such as excellent biocompatibility and biodegradability, significant encapsulation efficacy for lipophilic drugs with negligible drug leakage
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Combined hydroxyphenyl-modified adhesive with the ion-pair strategy for long-lasting delivery of clonidine in single-layer matrix-type patch J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-03-01 Chunlei Sun, Shuai Zhang, Jiali Xiao, Chao Liu, Liang Fang
Existing long-acting patches usually use controlled-release membranes to achieve constant rate delivery of the drug, which is complex and costly to prepare due to the 5-layer structure, so there is a necessity to develop a method to simplify the patch design and to control constant rate drug delivery. This study prepared a 7-day long-acting clonidine (CLO) patch using the ion-pair strategy based on
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Bioceramic materials in bone-implantable drug delivery systems: A review J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-29 Amit Kumar Nayak, Mala Maity, Harekrushna Barik, Sidhartha Sankar Behera, Amal Kumar Dhara, Md Saquib Hasnain
Since long, the applications of bioceramics in bone-implantable drug delivery has revealed a significant impact due to some favorable merits, such as excellent biocompatibility, good bioactivity, nonimmunogenicity, osteoconductivity, bone resorbability and controllable porous microstructure. To treat different disorders and diseases, such as fracture, osteoporosis, osteoarthritis, osteomyelitis, osseous
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In-vitro antibiofilm activity of polycaprolactone- poly (lactic-co-glycolic acid) nanofibers loaded amphotericin B, antimicrobial peptide LfcinB (21–25)Pal and zinc oxide for local treatment of periodontitis associated with obstructive sleep apnea J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-29 Mayra A. Téllez Corral, Jean C. Villamil Poveda, Nelly S. Roa Molina, Liliana Otero, Zuly Jenny Rivera Monroy, Javier García Castañeda, Claudia M. Parra Giraldo, Maria E. Cortés
Periodontitis has been linked to obstructive sleep apnea (OSA). The stage III periodontitis is more prevalent in OSA severe and the oral microbiome changes due to an increase in periodontal pathogenic bacteria and . Nanofiber drug delivery systems may be used for local antimicrobial therapy against microorganisms related to periodontitis and OSA. The aim of the present study was manufacture PCL/PLGA
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Self-assembling nanoparticles with antioxidant activity for ROS scavenging in liver cells J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-28 Valeria Nele, Stefania Melini, Virginia Campani, Alessia Angelillo, Sossio Fabio Graziano, Claudio Pirozzi, Rosaria Meli, Giuseppe De Rosa
Oxidative stress plays a crucial role in the pathogenesis of hepatic disorders, including non-alcoholic fatty liver disease (NAFLD) and its progression into hepatitis and fibrosis. In this context, the use of nanomaterials with ROS-scavenging activity might be a promising therapeutic approach. Here, we designed lipid self-assembling nanoparticles (SANP) enriched with a cerium core to obtain a ROS-scavenging
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Intratumoral implantable drug delivery system for targeted localized chemotherapy in breast cancer J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-28 Mohammad Souri, Sohail Elahi, M. Soltani
Breast cancer is a significant concern for many women, and local chemotherapy has emerged as a promising approach to address this issue. This study focuses on simulating the performance of chemotherapy using Doxorubicin, Cisplatin, Fluorouracil, and Methotrexate loaded in a dual release implantable system within a mathematical framework. The drugs are loaded in the implant as two forms: as free agents
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Antibiotic loaded inhalable liposomal nanoparticles against lower respiratory tract infections: Challenges, recent advances, and future perspectives J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-28 Vijay Kumar Panthi, Kathryn E. Fairfull-Smith, Nazrul Islam
Lower respiratory tract infections (LRTIs) are inherited disorders which often causes chronic respiratory infections for which patients repeatedly receive oral antibiotics, particularly during periods of worsened lung symptoms. However, the existing treatment modalities are often unable to completely clear the responsible pathogens, which contributes to the emergence of antimicrobial resistance (AMR)
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Agarose as a tunable platform for oral drug delivery: Controlled release of a highly soluble drug, theophylline, within a sequentially-changing-pH medium J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-28 T. Marras-Marquez, J. Peña, M.D. Veiga-Ochoa
The purpose of this study was to expand the use of freeze-dried agarose-based systems for the oral controlled release of highly water-soluble drugs. Three additives (Eudragit S-100 and RL-PO and Labrafac) were included within these systems together with Theophylline. The release of this drug from the rehydrated systems was evaluated in deionized water and in a sequentially-changing-pH medium that simulated
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An innovative synergistic combination using eudragit-coated galactosylated PLGA-pluronic nanoparticles for addressing colorectal cancer J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-27 Prasiddhi R. Raikar, Panchaxari M. Dandagi, Vijay M. Kumbar
The goal of this research was to find a way to enhance the pharmacological activity of Capecitabine (CAP) and Thymoquinone (TQ) while also decreasing the likelihood of drug resistance by studying the synergistic activity of TQ, formulating the functionalized polymeric nanoparticles (PNPs) as carriers for effectively targeting the colon to manage colorectal cancer (CRC). CAP and TQ-loaded galactosylated
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Graphene oxide and silicene as 2D platforms for complexation and intracellular delivery of siRNA J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-27 Leila Razavi, Heidar Raissi, Farzaneh Farzad
A successful small interfering RNA (siRNA) delivery system is dependent on the development of a suitable siRNA carrier. The reports have shown that two-dimensional nanomaterials could effectively deliver siRNA into tumor cells and induce a gene-silencing effect. To follow up on research, in this study, graphene oxide (GrO) and silicene (SIC) nanosheets as carriers for siRNA delivery are designed and
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Oromucosal spray products – Viscosity impact on spray performance evaluation J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-24 Francisca Bastos, Andreia Tabanez, Maria Aquino, António Nunes, Sérgio Simões
In recent years, the development of oromucosal drug delivery products has garnered significant attention as an opportunity for improved drug delivery and patient acceptance. Effective oromucosal drug delivery can be achieved through the combination of formulations with spray devices to tailor the administration.
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Cutting-edge advancements in anticancer drug delivery and scope for theranostics using biocompatible multifunctional mesoporous silica nanoparticles J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-24 Santosh Sarnaik, Dhananjay Bhatane, Sharon Rose Pamshong, Amit Alexander
With the advancement in nanotechnology, treatment of cancer has improved significantly in the past few decades. However, the hunt for exciting new generation of nanocarriers has no end. Mesoporous silica nanoparticles (MSNs), with their distinct properties such as high surface area and pore volume, high drug loading capacity, easy surface functionalization along with good biocompatibility, have emerged
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Metal Organic Frameworks for therapeutic approaches in cardiovascular diseases: A comprehensive review J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-24 Alireza Jenabi, Mohammad Amin Fathollah Maghsoudi, Milad Daghigh, Rouhollah Mehdinavaz Aghdam
The cardiovascular system (CVS) is one of the human body's pivotal organs, playing a crucial role in circulating blood throughout various tissues. Global statistics underscore the fact that cardiovascular diseases (CVDs) are responsible for the highest mortality rates worldwide. Recently, the utilization of different types of nanoparticles has gained significant attention in regenerative medicine.
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Polymeric nanofibers derived therapeutic approach for skeletal muscle regeneration: The promising future of muscle repair J. Drug Deliv. Sci. Technol. (IF 5.0) Pub Date : 2024-02-23 Khushali Nathani, Mansi Damani, Shubhada Mangrulkar, Sujata Sawarkar
Volumetric muscle loss (VML) represents a condition characterized by skeletal muscle injury inflicted due to trauma or surgery. In severe conditions, it leads to loss of regenerating capacity of the skeletal muscles, thereby making the management of VML challenging. Currently, surgeries, physical therapy, and cell-based therapies are employed for managing VML. These approaches possess certain limitations